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I- Obtundants
II- Mummifying agents
III- Antiseptics & Disinfectants
5 minutes BREAK
IV- Local Antifungal Agents
V- Demulcents
VI- Emollients
VII- Astringents
I-
Obtundants
Drugs
sensation of dentine tissue to
allow easy painless excavation.
* Ideal obtundant
* Members
(Local Anodynes & Astringents):
A) Local Anodynes :
1- They paralyze the nerve endings, but they produce initial stimulation
2- Example: Clove oil (Eugenol)
B) Astringents:
1- They precipitate cellular protein of nerve fiber
2- Examples
a- Alcohol 70%: ***
Astringet + Antiseptic
Denaturate
proteins
Phenol
Local
Anesthetic
Bactericidal
1-Domestic
2-Liquified phenol (Phenol in 10% distilled water):
- Analgesic & obtundant in toothache.
B) Phenol Analogues:
1- Cresol
2- Chloroxylenol (Dettol):
Antiseptic
3- Thymol:
-Bactericidal
-Fungicidal
-Anthelmintic
2) Alcohols:
Ethyl alcohol 70% Dehydration of proteins Denaturation
Precipitation Antiseptic and astringent useful in bed sores.
3) Acids:
1- Salicylic acid: Antiseptic, fungicidal & keratolytic.
2- Boric acid:
- Sodium borate (Borax) in glycerin (12% w/v) Paint for gum.
4) Aldahydes:
- Formaldehyde 37% solution Formalin:
a- 2-5% Disinfectant for instruments & gloves.
b- 10% Preserve & harden tissues
for histolopathology.
(Mummifying Agent)
5) Oxidizing Agents:
They release nascent oxygen Antibacterial action.
A) Peroxides:
e.g - Hydrogen peroxide: Antiseptic, deodorant & hair bleeching.
By tissues peroxidase enzyme Release of nascent O2
(act on living tissue which contain peroxidase enzyme so it is antiseptic and not disinfectant)
B) Permanganate:
e.g Zinc permanganate: Disinfectant & astringent.
A) Iodine:
1- Iodine glycerin 2% Mouth paint for gingivitis.
2- Iodophors: Povidone-iodine 10% solution (Betadin).
Iodine + Stabilizing agent or carrier
Slow release of iodine
B) Chlorine:
Chlorine in aqueous solution Hypochlorous acid
Oxidation of SH-containing enzymes & destroys cell membrane of bacteria.
1- Hypochlorites: Germicidal & dissolve necrotic tissue.
- Calcium hypochlorite (Eusol).
2- Chloramines: - Halazone tablets Disinfect drinking water.
A) Mercury Compounds:
- Merbromin (Mercurochrome): Bacteriostatic skin disinfectant.
B) Zinc Compounds:
- Zinc peroxide. (Oxidizing agent + H.M salt= pptn of prtn& enzymes)
C) Silver compounds:
- Silver nitrate eye drops (OBSOLETE).
Argyrosis = Blackening of the sclera
8) Dyes:
- Rosaniline dyes e.g. Gentian violet (crystal violet)
Antiseptic paint for infected wounds &
Thrush(infection)= monilial stomatitis (white patches)
More active & broader spectrum (Gram +ve & -ve BUT NOT viruses).
3- Non-ionic surfactants:
e.g. Polysorbates Emulsifying agent & NOT antiseptic.