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Applies to all paediatric patients from 1 month to 16 years 28th March 2007
Produce and disseminate clinical guidelines for the fluid management of paediatric patients
Audit programme to ensure that the NPSA recommendations are being adhered to
A Maulik Shah Presentation
Recommendation -NPSA
Oral fluids preferable to ivf
Resuscitation Fluids –
bolus of 0.9% saline
Deficit – calculated and replaced as
0.9% saline or 0.9% saline with 5% dextrose
Replace over 24 hours
Maintenance – do not use 0.18% saline with 4% dextrose
0.45%saline with 5%dextrose(D5-½NS)
A Maulik Shah Presentation
What about other countries…?
Royal children hospital, Melbourne.
Which Fluid?
0.18% NaCl with 4% glucose with KCl 20mmol/L is NOT the appropriate
initial fluid for unwell children.
Three good fluid solutions for sick children include:
Hyponatraemic encephalopathy
Common symptoms
Headache
Nausea & vomiting
Weakness
Advanced signs
Seizures
Respiratory arrest
Dilated pupils
Decorticate posturing
Slide courtesy:
child’s brain has a higher Coma Heinrich Werner, M.D.
Pediatric Critical Care
brain /intracranial volume ratio Pulmonary oedema University of Kentucky
Hyponatremic encephlalopathy kills…!
in hospitalized patients
Hypovolemia Euvolemia Hypervolemia
Typically done by
Symptomatic Hyponatremia
you and me !
Appropriate ADH Secretion Inappropriate ADH Secretion
Hypotonic Fluid
Hyponatremia
Osmolality : ADH level and Thirst
From:
Berl T, Robertson GL. Pathophysiology of Water
Metabolism. In: Brenner AM, ed. Brenner and Rector's
The Kidney. 6th ed. Philadelphia: W.B. Saunders;
2000:873. A Maulik Shah Presentation
Non Osmotic Stimuli for ADH Secretion
Stress Drugs
Pain Morphine
Post-operative period NSAID’s
Sepsis SSRI’s
Pyrexia Barbiturates
Nausea & vomiting Carbamazepine
Co-existing medical conditions Clofibrate
CNS infections
Isoprenaline
Respiratory disorders
Metabolic & endocrine disorders
Chlorpropamide
Vincrisitine
A Maulik Shah Presentation
Which hospitalized
child is not at risk
for SIADH ?
Slide courtesy:
Heinrich Werner, M.D. Pediatric Critical Care University of Kentucky A Maulik Shah Presentation
But why hypotonic fluid held responsible ?
IV SOLUTIONS Na(mEq/L) %EFW
5% Dextrose 0 100
ISOLYTE -P 26 84%
0.45% NS 77 50%
0.45 % NS in 5% Dextrose 77 50%
0.9 % NS in 5% Dextrose 154 0
Ringer Lactate 131 16%
0.9% NS 154 0
Sodium Principles
H2O
Sodium ions do
not cross cell H2O H 2O
membranes as H2O H O
2
quickly as water Na+
does Na+
different.!!!
A Maulik Shah Presentation
So is “ISOLYTE- P” out ??
Not fully – Why…?
Hypotonic solutions should be administered if the goal is to create a positive balance
for EFW:
1. To match daily loss of EFW in sweat in a patient with PNa > 138mM
2. PNa > 145
3. Ongoing free water losses (Renal, GI, skin) or a free water deficit
so use in
NEONATES.
Established third space overload : e.g. congestive heart failure,
nephrotic syndrome, cirrhosis A Maulik Shah Presentation
Let’s Share our views on this…