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ABSTRACT
Howland circuits have been widely used as powerful source for exciting tissue over a wide frequency range. When a
Howland source is designed, the components are chosen so that the designed source has the desired characteristics.
However, the operational amplifier limitations and resistor tolerances cause undesired behaviors. This work proposes to
take into account the influence of the random distribution of the resistors in the modified Howland circuit over the frequency range of 10 Hz to 10 MHz. Both output current and impedance of the circuit are deduced either considering or
the operational amplifiers parameters. The probability density function due to small changes in the resistors of the circuit was calculated by using the analytical modeling. Results showed that both output current and impedance are very
sensitive to the resistors variations. In order to get higher output impedances, high operational amplifier gains are required. The operational amplifier open-loop gain increases as increasing the sensitivity of the output impedance. The
analysis done in this work can be used as a powerful co-adjuvant tool when projecting this type of circuit in Spice
simulators. This might improve the implementations of practical current sources used in electrical bioimpedance.
Keywords: Howland Current Source; Electrical Bioimpedance; Probability Density Function; Resistors Mismatching
1. Introduction
Because of its simplicity, stability and other advantages,
the voltage controlled current source (VCCS) has been widely used in many applications, such as in neuron-stimulation systems [1-3], single-electrode capacitive sensors
[4], electrical impedance tomography (EIT) systems both
for industrial and medical applications [5,6] and bioimpedance analysis (BIA) for tissue characterization [7,8].
It is also been used for exciting tissue for cancer characterization in electrical impedance spectroscopy [9-11].
Most VCCS circuits in BIA use the Howland current
source (HCS) [12]. The first HCS circuit was proposed
by Howland in 1962 [13] for converting a voltage into a
current. However, it suffers from output voltage compliance [7]. Therefore, the modified version of the circuit
has been proposed and widely used [14,15].
The most important requirement in EIS systems is to
assure that the injecting current, also called source current, has constant amplitude over a wide frequency range,
which should be obtained by a high output impedance
circuit [7]. However, stray capacitances [4] and non*
Corresponding author.
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P. BERTEMES-FILHO ET AL.
I out
V3 Vout V1 Vout
R4
R5
A A j
Ao
1 j co
(4)
(5)
(6)
where Rin and Cin are both input resistance and capacitance of the opamp, respectively.
The Norton theorem can be applied to the circuit
shown in Figure 1 then the shunt impedance ZN of the
circuit can be calculated by Equation (7) and the transconductance gain GN can be calculated by Equation (8).
Z N I out Vout V
(7)
GN I out Vin V
(8)
in 0
out 0
(1)
V2 Vin V2 V1 V2 V3
0
R2
Z in
R3
(2)
V3 V2 V3 Vout V3 V1 V2 A
0
R3
R4
Ro
(3)
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1
1 Rin jCin
This program was implemented in R scripting language, which is a language and environment for statistical computing and graphics. In this work the resistors
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P. BERTEMES-FILHO ET AL.
R2 R4 R5 R1 R2 R4
R2 R5 R2 R4 R1 R3
(9)
Z out,min
rR
2 R r
(10)
Frequency
Cin (pF) R0 ()
A0 (dB)
c0 (Hz)
OPA657
1000
0.7
0.02
75
600,000
OPA656
1000
0.7
0.01
66
200,000
OPA655
1000
1.2
0.04
58
400,000
LMH6654
1.8
0.08
80
50,000
OP07C
50
NF
60
115
TL081
1000
3.0
10
105
50
uA741
1.4
75
97
30
Note that A0 of the opamp has been extracted from the plots of the open-loop
gain versus frequency presented in the datasheet.
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R2 RE1 A RE1 R2 R3
A RE 2 R1 R3 R2 R3 R1 RE 2 R2
(11)
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P. BERTEMES-FILHO ET AL.
R2 R5 R4 R1 R3 Re a0 A 0
(17)
By considering negligible variations in the denominator of Equation (12) and also assuming only real values
for the coefficient a0 (see Equation 13), the Zout phase can
be given by (a1 + a0/A) and the modulus by rR(2R
+ r)/|a1 + a0|. The term a1 + a0/A represents a horizontal line in the complex plane, so that the product between |a1 + a0/A| and sin[(a1 + a0/A)] is always constant. Therefore, Zout can be approximated by a circumference of radius |Zout,max|/2 according to Equation (18).
Z out Z out,max sin Z out
Figure 3. Probability distribution of the output impedance,
using the OPA655 and resistor tolerances of 1%.
rR r 2 R
a1 a0 A
(12)
where
r 2R
a0 2 R r R 2
Z in
(13)
a1 R2 R5 R4 R1 R3
(14)
A A0 cos A
(15)
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rR r 2 R
Im a0 A
(16)
(18)
P. BERTEMES-FILHO ET AL.
455
Figure 4. The real and imaginary part of the output impedance by using resistor tolerance of 0.1%.
Figure 5. Changes in the output impedance at 10 kHz by using different resistor tolerances.
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P. BERTEMES-FILHO ET AL.
Vout1
Vout2
I N1 Z N 2 Z N 2 I N 2 Z N 2 Z L Z N1
Z L Z N1 Z N 2
I N1 Z N1 Z L Z N 2 I N 2 Z N 2 Z N1
Z L Z N1 Z N 2
(19)
(20)
I N 1 Z N 1 I N 2 Z N 2 (21)
Z L Z N1 Z N 2
I N 1 I N 2 Z N 1 Z N 2 VN 1 VN 2 Z L
Z L Z N1 Z N 2
(22)
6. Discussions
6.1. Output Impedance
Figure 6. Schematic diagram of the mirrored modified
Howland current source.
Figure 7. Equivalent Norton circuit for the mirrored modified Howland current source.
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P. BERTEMES-FILHO ET AL.
output of the Howland current source have not considered any stray capacitances which might be found in
practical circuits. Also, the numerical solutions for both
output current and impedance of the circuit have not
considered the common-mode input impedance of the
operational amplifiers, as well as the common-mode rejection ratio (CMRR). It has to be pointed out that the
probability density function was used by assuming that
the resistor variations behave as a normal distribution.
Therefore, care should be taken when analyzing the results obtained in this work, especially when they are related to practical circuits.
7. Conclusions
It was fully described the modeling of both output current and impedance of the Howland current source by
considering the operational amplifier parameters and the
mismatching between electrodes. It was shown that the
output resistance of the operational amplifier does not
play a role in the output characteristic of the Howland
circuit whereas the open-loop gain causes a great impact
on it.
It was also shown that the higher the gain, the most
sensitive is the output impedance in respect to the resistors tolerances, as illustrated in Figures 4 and 5. In order
to operate at high frequency, the open-loop gain of the
opamp has to be very high. This explain why the resistors
have to be precisely matched in order to obtain a
MMHCS circuit which can deliver a constant differential
output current into the load over a wide frequency range.
It can be concluded from this work that both side of
the MMHCS should be very symmetrical if high output
impedance from this type of circuit is desired. This is a
very significant achievement found in this work for the
design of high output impedance Howland current sources
used in bioimpedance measurements. This may lead to
empirical distribution of important characteristics of the
MMCHS during the design and it might save time and
money when this type of circuit is put in production scale.
Furthermore, the error estimation provided here can
guide researchers, who have no previous knowledge in
Howland current source, to design a high quality circuit
in terms of both output current and impedance spectra
according to the application requirements.
8. Acknowledgements
This work was supported by the State University of Santa
Catarina and the National Council for Scientific and
Technological Development (grant 237931/2012-5).
REFERENCES
6.4. Limitations
The analytical analyses and the equations related to the
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[1]
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P. BERTEMES-FILHO ET AL.
Practical Considerations for the Use of a Howland Current Source for Neuron-Stimulation, Proceedings of the
IEEE Biomedical Circuits and Systems Conference, Baltimore, 20-22 November 2008, pp. 33-36.
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P. Bertemes-Filho, Tissue Characterization Using an Impedance Spectroscopy Probe, Ph.D. Thesis, University
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