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Faculty of Health Science

rvl- PFJAIIIM_
I Semester Examination,

2008 lll Semester Examination, 2009

ll Semester Examination, 2008 lV Semester Examination,2009

,Price : Rs.23.00

,s H-If FOGK EEPSE

opP, TADKE$HWAR

TEMPLE,
'1s7, $HAURA RASTA, JAIFUR

TTAJASTHAN UNIVERSITY OF
HE,A.I-TH SCIENCES JAIPUR

SYLLABUS
SCHEME OF EXAMINATION AND
COURSES OF STUDY
FACULTY OF HEALTH SCIENCE

M. Pharm.
First Semester Examination
Second Semester Examination
Third Semester Examination
Fourth Semester Examination

SHTV BOOK T}trPOT

Opp" Tadkeshwar Temple, 167, Chaura Rasta, Jaipur

Sy

llab us : M a st er of Phammcy

MASTERS DEGREE

l.

IN PHARMACY (M.Pharm)

ACADEMIC REGULATIONS
Duration of the course
The duration of the M.Pharm course shall be of two academic
years (four semesters). The cour'se of study for M.Pharm shall
include first semester, second semester, third semester and final
semester, each of 15 weeks duration (excluding days spent in
examination).

2.
2.1

2.2
2.3

Etigibility for admission

A candidate who has passed B.Pharm with at least 55% marks
(Aggregate of 4 years i 3 years for lateral entry admission) (for
SC/ST candidates, the pass percentage at the qualifuing
examination) from an institution approved by PCI and AICTE.
Preference will be given to GATE qualified candidates.
For sponsored candidates
A Pharmacy Graduate, fuifilling conditions mentioned in section
2.1 and having 2 years of full time professional experience in
a registered pharmaceutical companyl educationai and/ or
research institution/ any govemment organizaticn shall be eligible
for admission under sponsored category.
Sponsored candidates shall have to submit a sponsorship letter
fiom their employer along with the application forrn for admission.
The letter must also mention the length ofcandidate's cmployment
with the sponsor and the undertaking that the sponsorship shall
not be withdrawn before the completion of the course.
Sponsored candidates shall not be eligible to receive scholarship,
if they are admitted on the basis of GATE score.

even

2.4

will be no age restriction. However, candidates below 45

of age shall be preferred.
Admissions will be made in order of merit. For preparing merit,
There

years

2.5

equal weightage shall be given to aggegate percentage of marks

O Rajasthan University of Health sciences Jaipur

Publtshed b1' Shiv Book Depot, Jaiput

for University of Rajasthan

Printed by Harihar Printers, Jaipur
lypc Sctting M.M. Computet & Graphics, Jaipur

obtained in B.Pharm and GATE.

will

be made as per State Govt. / University rules.

In case ofnon availability ofreserved category candidate(s), the
reserved seat(s) shall be filled up by general category candidate(s).

Reservations

Raj asthan llniausity of I lealth S ciences

+
a

Scheme

3.1
aa
J.L

4.
4.1

4.2

of StudY & Examination

Syllabus: Master of Pharmary

approval ofthe supervisor and the head ofthe institution. Ifthe
appointed supervisor leaves the college/ is likely to be absent
for a long period, the head of the institution s'rall appoint another
sufervisor. The candidate shall continue the dissertation work
on the topic approved earlier.

Bnglish.
The medium of instruction and examination slrall bc
ancl
Candidates for the M.Pharm course shall be instructed
and
Schcme
Examination
examined as per the Teaching and
Course Content of respective specializations'

Eligibility for appearing in the examination

Attendance Requirement: In order to be eligible for University
75 ol
examination, a student must be present in not less than
of theory and practical classes of each subject'
the
A candidate who has attended a regular course of study for
to
eligible
first semester in an academic institution shall be
at the M'Pharm first semester examination of the

4.5

as prescribed under the relevant regulations for the final

semester shall be eligible to appear at the final semester
examination for N4.Pharm. During M.Pharm. final semester,
candidate shall continue the dissertation research work of the
third semester.

ufp"u.

University.
4.3

4.4

4.5

per
A candidate who has been promoted to second semester as
a
attended
the provisions for conditions of passing and has
of study in an academic institution for the second
."goiu,
"ourse be eligible to appear at second semester
seirester shall
examination for M.Pharm.
A candidate who has been promoted to third semester in an
of
academic institution as per the provisions for conditions
work up
passing and has completed the dissertation research
the
under
prescribed
io the satisfaction of the superuisor as
appear
to
relevant regulations for third semester shall be eligible
at the third semester examinati':n for M'Pharm'

Atthe beginning of M.Pharm' third semester, for each candidate'

head ofthe
a dissertation supervisor shall be appointed by the
institution. The candidate shall choose a topic for dissertation
survey
in consultation with the supervisor' carry out literature
dissertation
a
submit
on the propoSed dissertation topic and
the supervisor
synopsis including plan of work duly signed by
shall
candidate
The
approval'
for
to tne UeaO of the institution
approved
the
on
work
then carry out the dissertation research
under the
dissertation topic at the institute running the course
also
guidance of respective supervisor' A candidate may
institute/
other
any
at
work
i"rfo.m his/ her dissertation
subject on
iaboratory/ industry as per the reqttirelnent oi'the

candidate who has been promoted to final semester as per

the provisions for conditions of passing and has completed the
dissertation research work up to the satisfaction ofthe supervisor

5"
5.i

Sessional (Internal assessment)

Theory sessionai (25 rnarks):
Written

test

Seminar and/or assignment

: 15 marks
: l0 marks
: 25 marks

Total
(i) Written test (15 marks):

At least two written tests of 15 marks each in every theory

subject shall be conducted by the institute at regular
interval during each semester. The average of best two
performances shall be taken into consideration for the
purpose of computation of corithen test marks' Duration
of each written test shall be of one hour.

(ii)

Seminar and/ or assignment (10 marks):

Every student shall present a subject seminar and/or

submit assignment on the topic assigned by the subject
teacher.

5.2

Practical sessional (25 marks):

Practical

: 15 marks
practical work : l0 marks
: 25 marks

test

Day-to-day

Total
(i) Practical test (15 marks):
At

least two practical tests

of

15 marks each in every

Raj asthan lJniaersil:y of H eulth

ciences

practical subject shall be conducted by the institute at

regular interval during each semester. The avorage of best
tWo performances shall be taken into consideration fbr the
purpose of computation of practical sessional marks' The
duration of each practical test shall be or'6 hours. Each
practical test may be conducted in different pafts viz'
synopsis/ spotting, exercise/ experiment and viva-voce

Syllabas : Master of Phannacy

s.6

disserlation by appearing in one additional sessional examination.

The aggregate of best two performances from all the sessionals
shail form the basis of calculating the average far computation
of irnproved sessional marks. Marks for day-to-day assessment
in the practicals cannot be improved unless a candiclate attends
a regular course of study again.

etc.

(ii) Day-to-day practical worV

experiments performed

University examination

(10 marks):

The concerned teacher shall evaluate the dayto-day

practical work/ experiments performed in the laboratory
on the basis of the performance of the student' viva-voce
and maintenance of practical record'
5.3

University examinations for all the four sernesters are to be held

twice in a year, as per the Teaching and Examination Scheme
and Course Content, in the months of Dec.lJan. and June/July
or on such dates as may be fixed by the University.
6.2

hours duration" There shall be 7 questions carrying equal marks,

The students shall carry out professional work as allotted by the

head of the institution in M.Pharm. first and second semesters'
The professional work shall include perforrna,rce of lab. dttties,

out of which 5 questions shall have to be attempted.

University examination in each practical subject shall be of 6

6.3

hours duration and shall cor-nprise of synopsis / spotting, exercise

/ experiment and viva-voce etc. The head of the institution shall
send the awards to the Universiry on or before the prescribed

samples etc.

Dissertation sessional (50 marks):

For M.Pharm. third and final semester dissertation sessional, the
candidate shall submit a copy of dissertation progress report
printed or tlpe written, containing the results of hisfter dissertration
research work duly signed by the supervisor and forwarded to
the head of the institution, on or before the prescribed date.

date

7.
7.1

The record of marks of sessional examination for each student

shall be maintained by the academic institution and must be
submitted to the University before the commencement of
University examination.

Dissertation
For M.Fharm. third semester Universiry" examination, the
candidate shall subrnit four copies of dissertation report, printed
or type written, in spirally bound form, containing the results of

his/ her dissertation work duly signed by the supervisor and

countersigned by the head ofthe institution.

The evaluation shall be on the basis of serninar and dissertation

progress report, presentation and viva-voce and shall be done
by a board consisting ofdissertation supervisor and one teacher
of the subject.of specialization (to be appointed by the head of
the institution). The average of the marks awarded by the board
members shall be considered for the purpose of computation of
dissertation sessional marks.
5.5

University examination in each theory subject shall be of three

Professional practice:

analysis of
5.4

A candidate failing in uny of the subjects shall have a chance

to improve his /her sessional marks in theory practical and

l'he evaluation shall be on the basis of dissertation report,

presentation and viva voce and shall be done by a Board
consisting of dissertation supervisoq external examiner appointed
by the University and the F{ead of the institution who shall be

the chairman of the board.

The chairman shall then send the awards to the University, on

or before the prescribed

t.2

date.

For M.Pharm final semester University examination, the candidate

shall submit four copies of dissertation thesis printed or type

llaiasthanllniaersity of Health

Sciences

Sy

llabas : M ast er of Phavmacy

semester.

written, in bound form, containing the nesults of lris/ her research

work. The dissertation thesis shall bear a certificate from the
supervisor countersigned and duly forwarded by tlre Head of
the institution, on or before the prescribed date, certifoing that:

(i) the work has been undertaken

and cornpleted and the

his/ her superttision
under
dissertation has been written
and guidance and meets the requirements uf the course;
(ii) the dissertation is a bonctfide record of the original work
carried out by the candidate and the di-ssertation work
has not fornted the basis of award of any other degree
or diplorna etc. of this or any other University.
The evaluation shall be done on the basis of dissertation thesis,
presentation and viva voce and shall be done by a Board
consisting of dissertation supervisor, external examiner appointed
by the Universitv and the Head of the institution who shall be
the chairman of the board.

report after pursuing research vvork as suggested by the board

on the same dissertation topic. Sucli a candidate will have to
reappear as an ex-stuCent in the next M.Pharm third semester
U

candidate, who has failed in M'Pharm final semester

examination, shall be furnished by the Board [Point 6(d)] with
a clear statement of reasons for failure and suggestions for
improvement. He/ she shall revise and resubmit tlie disseftatioir
thesis after incorporatin. suggestions made by the board on the
same dissertation topic. Such a candidate will have to reappear
as an ex-student in next M.Pharm final semester University
examination.

8.6

In no case shall a candidate, who has not passed finally after

six academic years from the date of enrolinent, be ailowed to
continue the course.
The Vice-chancellor in consuitation with the Head of the
institution -;ray waive this limit of six academic years. The
reasons for waiving the limit shall be recorded in writing. Sucli
extension shall not exceed one year.

8.1

A candidate who is unable to appear at any examination in any

subject(s) due to any reason whatsoever shall be considered as
having failed in that subject(s).
Award of I)egree, f)ivision and Rank
On satisfactory cornpletion of the course and after passing all

Conditions of passing
A candidate shall be declared to have passed irr a sub.iect when
he/ she has secured 50% of the maximum marks in the sessional
and University examination marks put together separately in
each theory and practical sub.jects and dissertation sessional and

dissertation university examination.

8.2

in any subject(s)
(Theory and practical counted as separate subject) in first or

A candidate who fails to obtain

500/o marks

second semester examination, shall be eligible for promotion to

second/ third semester. Such candidate shall have to appear
again in failirig subject(s) in the subsequent examination'

8.3

No candidate will be eligible for submitting the dissertation thesis

unless he/ she has passed

in all subjects of firs# second

semester.

candidate, who has failed in M.Pharm third semester

examination, shall be furnished by the Board with a clear
statement of reasons for failure and suggestions for improvement'
He/ she shall not be allowed to pursue course for M.Fharm final

8.4 A

niversity exam ination.

8.5 A

The chairman shall then send the awards to the University, on

or before the prescribed date"

8.
8.1

He/ she shall revise and resubrnit the dissertattotl

9.
9.1

the semester examinations. a candida-te shall be awarded degree

of M.Pharm in the respective branclr.

9.2 No division shall be awarded at tlie end of Vl'Pharm first,

M.Pharm second and M.Pharm third semester examinations.
The division to a successful candidate shall be awarded on the
basis of aggregate of marks obtained by him/ her in M.Pharm
first semester, M.Pharm second semesteq M'Pharm third
semester and M.Pharm final sernester examinations regardless
of the number of attempts. as shorvn belon':

Percentage
75Vo

of

or above

marks

Division
Honours

Raj asthan Uniaersity of Health Sciences

L0

First l)ivision
or above
Second Division
50% or iibove
A candidat"e will be said to have passed a paper with distinction
if ire/ she secure 75Yo or more marks in the concenred paper'
'Ihe actual marks (and'not the passing marks) as obtained by
a candidate in a supplementary/atternpt examination shall be
counted for award of division.
Rank and university gold rnedal.shall be conferred to those
candidates rviro have passed the whole examination in fir:st

y ll

nbus : M ast er of PharmacY

Teaching & Exanninaticn Scheme

M.Pharm (Pharrnaceutics)

60%*

9"3
OA

9"5

attempt (without any grace) and such candidates shall be eligibie

for any prize or scholarship.

L1

First semester
Paper
No.

Teaching

Subject

Marks

Univ.

hrs. per exarn. Sessi Univ. Total

onal

week

hrs.

Research, Theory
L{ethods in Pharrnaceutical
Research, Practical
M.PHIl3T Product Devclopmenl.

Theory
M.PI{l l,lP Product Development,

25

Practical

M.PHl I5T Advanced Pharmaceutics

& Biotechnology, Theory

ProfesSional Practice

36

Total

Exam

75
75
'ts
75
75

100
100
100
100
100

:
t2s 375 500

These hours will not be counted as workload of Teacher.

Second semester
Papcr
No.

Marks
l-lniv.
hrs. per exam. Sessi Unir'. Total

Teaching

Subject

week

hrs. onal

Exant

Advances in
Pharmaceutical Sciences
including Biostatistics,
Theoqv

M.l22P

.)

23

?5
25
25

Pharmaeeutical Sciences
including Biostatistics,
6

Practical

M.Plil23T Nnvel Drug Delivery

Systern, Theory

M.Pl-ll24P Novel Drug Delivery

6

System, Practical
M.PI-II25T Biopharmaceutics and
Pharmacokinetics, Theory
Professional Practice
Total

75

i00

Advances in

'l'hese hours

75

i5

tfn

75

100
100

:,:
125

375

not be counted as workload of Teacher.

500

Ra! asthan Unia ersity af Health

12

Third semesten
Paper Subject
No"

ciences

Teaching
hrs.

per

Marks
Sessional Llniv.Exam Total

Week
M.PH2I

lD

Dissertation (Report,
Presentation &

Viva-voce)

'K

50

150

200

Finatr semester

Faper

Subject

Teaching
hrs.

i\o.

per

Marks

Sessional Univ"Exarn Total

M.PFD2lD Dissertation (Thesis,

Presentation &

Viva-voce)

50

150

200

f-

7J

19
:Mast*of PhaflnacY
COURSE CONTENT
,Pltgrrn (Pharmaceutics, Pharmaceutisal chemistry, Quality

lrharmacolory, Pharmaceutical Managernent and Regulatory

"uruoru.
lrr l

COMMON SUBJECTS
lcmcster
Methods
,11 l'[
Theory

in

Pharmaceutical Research,

60 IIrs.

UV-Visible spectroscopy: Brief review of electromagnetic

ible range, enerry-wavelen gth--co lor relationships'

tion ol'electro--magnetic radiation (uv-vis) and matter and its
Itt, chromophores and their interaction with E.M.R. Absorption
lrn ol' organic compounds and complexes illustrating the
r.

l,J

V -V

,u,, ornd its utilization in qualitative and quantitative studies

of

rtrills and their interpretations (including solvent effects); photo-

lc

spcctroscoPY.

Itrl'ra-Rod spectroscopy: Nature of LR. radiation, interaction of

H{latiorr with organic molecules and effects on bonds, molecular
I.R. instrumentation and
lAfla-roU spectra, brief outline of classical
for spectroscopy,
preparation
sample
including
ifgfr:tnti()n of spectra
methods and
quantitative
tlve irrterpretation of I.R. spectra,
Htlvtutces in I.R. spectroscopy including FTIR, ATR, etc'

Nrrcleur Magnetic Resonance spectroscopy: Fundamental

lpler ol'NMR (magnetic properties of nuclei: applied field and
on: atrsorption and transition frequency), ctremical shifts
. lirr:tors affecting chimical shift, isotopic nuclei, reference
I l)roton magnetic spectra, their characteristics, presentation,
unerl in describing spectra and their interpretation (number

and irrtcnsity of signal), briefoutline of instrumental arrangements

t0rtrc proctical details, signal multiplicity phenomenon in high

and
lUtlun i,MR; Spin-spin coupling, application of signal splitting
exchange
Ittg constant data to interpretation of spectra, proton
lon;, clecoupling and shift reagent methods"
r3CBriel'outline of principles of FT-NMR with reference to
I Spin-spin and spin-tatticerelaxation phenomenon, free induction

(lilt)). proton

noise decoupling, signal averaging tirne domain

Rajasthan Unia er sity of H e alth

20

and frequency domain signals, nuclear overhauser enhanceme

NMR spectra; their presentation, characteristics, interpretaticn,
and applications.

Brief indication of application

of, magnetic resonance

data of other nuclei by modern NMR instruments, introduction

D NMR techniques.

'

Mass Spectrornetry: Basic principles and brief outli

instrumentation, ion formation and types; molecular ions, rneta

ions, fragrnentation processes' fragmentation patterns and
characteristics in relation to parent structure and functional
relativb abundances ofisotopes and their contribution to cha

i
chemical ionization rnass spectrometry GC-MS including
peaks, mass spectrum; its characteristics, presentation and

advances in MS, Fast atom bombardment mass spectroscopy;

of drugs in biological sarnples by combined GC- MS.

of drugs and their

using column chromatogaphy, paper chromatography, TLC,

exchange chromatography, GC, GLC, HPLC and HPTLC.
Electrophoresis: Moving boundary electrophoresis,
electrophoresis, iso-tachophoresis, iso-electric focusing and
electrophoresis.

Flourimetry and chemilumniscence: Principles, inst

and applications; electro-chemiluminescence' resonant ionization
I-aser-enhanced ionization.
X-ray crystallography, thermal methods of analysis, DSC,
eto.

M.X12P

Methods
Practical

in

Fharrnaceutical Researeh,

Experirnents $ased on calibration and validation

of

Qualitative and quantitative analysis cf phannaceutical

and dosages having single component or in combination of foll
categories: (biological and microbiological methods excluded)'
i) Alkaloids ii) Antibiotics

Barbiturates

vi) Sulfa

drugs.

iii) Steroidal homones iv) Vitam

of Phalmqcy

2\

ll.V./ Visible spectrum scanning of certain organic compounds,

chrnrltliotr and correlation of structures, comparison .8.,
ltftrraltpltctricol, analgin, paracetamol, sulphadiazine, Ibuprofen etc.,
efter't ul' pll and solvent on UV spectrum of certain drugs.
liclinrntion of single drug (raw materiaV formulationg) by colorimetry
lnvnlving dif ferent reagents.
Doterrnination of UV cut off wavelength for different solvents.

Firtinrution of single drug (raw materiaU formulations) by W

lFotr(ll)hotometry.
Slrnultaneous estimation of paracetamol and ibuprofen and other
flg;nhirrntion formulations by W spectrophotometry using simultaneous
ffl$et [rrrs/ derivative spectroscopy/ multiwavelength spectroscopy etc.

('untpnrison of three different analytical methods for salbutamol

ffi ulltor

Chromatography: Basic principles, instrurnentation'

techniques and quantitative analysis

tyllalun: Nlnster

drugs.

('alibration of IR spectrophotometer using polystyrene film and

Sheehhrg thc performance of the instrument.
Recording IR spectra for known drugs and comparing with that
ff Phanrrucopoeia, estimation of drugs using lR.

lR rpectra of simple molecules and interpretation of the same.

E:tiuration of drugs bY flourimetry.
llrtinration of drugs by flame photometry'
Strur.:tural elucidation of at least 5 unknown compounds using UV,

NMR and Mass spectral data'

iemester
60 Hrs.
Advances in Pharmaceutical Sciences
ltl'f
including Biostatistics, TheoIa
Blrutatistics: The application of the following in pharmacy shall
gnvorod,

MEan. nredian and mode, standard deviation and coefficient of

lorr. students t-test, one way ANOVA, chi-square test, probability,
y distribution, regression analysis, bioavailability-cross-over
signed rank test, introduction to control charts.
Wilcoxon
,
Phanr ur i n l'ormatics : lntroduction to information resources available
th lulernct for the various subjects in pharmacy.

22

Rai'asthunllniaersitg ofHealth

Syllabus:Masteraf

factorial desi gns, centr

Experimental Designs : lntroductiorrr to fu l l
of full antdreduced mathematical rnod'e
designs,
.---r:^^!:^-^
tha pwnerirncnfsl
"uJlution
designs fi
"ornporin"
^^f the
experimental desiEnS
experimental designs, applications oof

in

the subjects mentioned

"na"t

pharrrnainformatics' introduction

contour Plots.
of patents' conditi
Patents: Definition, need forpatEnlting' types

tobesatisfiedbyaninventiontobepatentable'introductiontopa
search.
preparation
The essential elements of patent;;; Guidelines for
laboratory notebook, non obviousnegs in. patent'.drafting .of ,1at
introduction to
claims, imporant patent related web-sites, brief
protection and WTO Patents.
in 1999'2
lntrocluction to 'The Patent Act I '970' as amended
on
&2005 and the rules made there und@r, with special emphasis
application'
patent
forms to be submitted along with a
drugs: analg
Biological evaluation of the foliovwing classes of
and di
agents
anti-inflammatory agents, tranquilizers, hypoglycemic
agents.

Introduction to various stages ir:r process of drug develt

for drugs and
scope and aims of preclinical and clirnical trials
forms.
drugs' mono
Pharmacopoeial methods for evarluation of crude
L,O' p''
po lyherbal formulation s by F.O' M' deaterminatig'n'
"th :.ilY
'"i*u"iin. value, phyomorphology, mfi croscopial methods' quantitati
microscopy, quafit;tive analysis, pest:'icide analysis' Ti":"|:"t .":it:
like uv,
determinaiion and evaluation uy otherr advanced methods
GLC, HPLC, TLC, & HPTLC etc'; automated analysis
aided Analysis.
Drug Stability: Solution stability, solid stability' parameters
testing p,rogr
physical itability testing, protocol for physical stability
accelerated studies and shelf life as:stgnment'
90
Advances in Pharrirrceutical Sciences
Practical
including Biostatistic:s'
Animal experiments for deterrmination of activity' potency
toxicity of drug substance and doszuge forms'
Parameter studies for physical itability of drugs'

M.l22P

Pharmacy

23

Shelf life study of formulations.

Evaluation of crude drugs.
Evaluation/ standardization of extracts based on WHO guidelines.

Isolation, separation, purification and identification of important

phytoconstituents.
Practical exercises based on Student 't' test, one-way ANOVA,
Chi-square test, first and second order equations, calculation of Rf
value, mean, median, mode, standard deViation, Stoke's linear trapezoidal

rule.

Curnulative percentage drug release, linearregression, and other

sirnple programs of pharmaceutical interest'
Practical exercises based on biostatistics and statistics in clinical
research.
Preparing protocols on various validation requirements.
^,.*ina\

M'Fllaren (Fharxnaceutics)
Finst semester

M.PH.Xtr3:f Product Develcpment',

T'heory

60 Hrs.

Fundamental Aspects of, Froduct Developrnent: stmdies ol'

weftabilib,. solubility, dissolution, partiticn and absorption, surfactant
and hydrocolloitls and their role in drug delivery and targeting.
Deslgning of oral Flrannaceuticals: Formulation, evaiuation,
stability siu<iies and recent ac{vances in dosage 'fums;tablet, capsule'
,"rp"nri.r,',, emulsion: microencapuslation, advances in cclating
techniques.

of
Development of Parenterals: concepts, forrnulation, evaluation
and quality
large and small volurne parenterals, environmental control
assurance in manu&cturing.

Opirthalmic Freparations: Introduction, physiology of eye'

fbnnulation considerations and evaluation of ophthalrnic products
(ointments, suspensiot-1, eye drops, contsct lenses, occuserts etc')'
containers and ciosures.
Pulmonary Freparaticns: DIll, Aerosols: flasic preparatic'n and
type of preparations, formuiaticn and evaluation, containers' receut
develol:ments of pressurized dosages forms'

fLaj *sthart l.trttizt wsity of Mealth

cience:t

oI
5e1";*tion of suppository bases' cirara*teristics
Supposirories:
"f,orrnulation,
tll
pactrraging
preparation, evaluation ancl
bases,
t'
suppos itones, siabi I ifv studies and necent developrnen
of skirr'
Derrnatological Freparations: Anatomy and physiology

.rnechanismoiabseirptionthroughskinincludingmathematiealtreatmettt.
paste, gels inciuding
feirmuiaticrn and evaluation of cintments, creams,

herbal cosrnetic creams"

physical antl
Stability Studies: Basic concepts, consideration of
life' problenrs
ctrernical staUitity studies, determination of shelf
encountered during storage of dosages forms'
90 Hrs'
M.PI{.114 P Froduct Developrment, Practical
Validation of dissolution test apparatus'
polymer.
Determination af molecular weight of'the given
dispersiott
Enhancement of solubility of the given drug by solid
technique"
Perferrrnance

of powder glass test on different type of

glasscs'

glass containcr'
Perfbrmance of,water attack on treated soda lirne

drug'
Formulation and evaluation of matrix tablet of given
gels of some anti
Fon'nulation and characterization of topical
inflammatory drugs.
and sustaincd
Comparison of reiease rate profile of conventional
release tablets.

Preparationofmicroeapsulesbydifferenttechniquesandthcir
evaluaticn.

f)eterminationofshelflifeofaspirinbyacceleratedstability
studies.
size en
Evaluation of spherical crystallization as a particle
teehnique for asPirin.
Formulation and evaluation of ophthalrnic dosage forms'

Perforrnanceofplrysicalstabilityanddissolutiorrstudiesofl
of given drug.
drug'
Fonnulation and evaluation c'f suppositories of given
physr
Deterrnination of the elfect of process variables on
microcapsu
of
profile
chemical characteristics anel in-vitro releasc

suspension

,, i

!,tl,

rt.

Alrrsfr,i u.f Phawmntr

rr l'tl ll5tr'

,'l"dvanced Fhalrmaceuties 6;

6{}

E[r:r.

tr]itltechms)fi#gy' Tle**ry
I ,,r rrrrr!:rtron (lonsicieratinns: Prefbrmtllatiori stirdies ii1 glsr"rgir-rprieilt

i' l,,r :rl l irlu id and parenteral dosage fbrms; solnhil itg dissolution
! rr, i'l'.i p;rr'{ilioncoefficient,stabili4retc.,h-vivoe'v-atrua'iiontec}uiiques.
,

.'

l'r,,rirrcliorr Management and Documentati*n; ISC 9$0S series"

;,rr, lli r trr;rl proJrcftyrights,total quaiityman&gernnt.GMFanetrqualit-v
,i ,!ri!u( r', vrrlirlltion fcrr tablets and parenterals, practice o1'Wl{O

": ll'

i'rl,t

I'lirrrt Scale r-rp'fechniques: Significance of pilot plant scale

,,i, 1,ir;r',r'. !,rlronrlory procedure and forrnulations, routine procltlction
1,,,', ',lrr,. rlrscrrssion on important parameters such as fcrrmulatiun,
; tii,l,,,,i rri , r'tr:. pilot study of dosage forrns such as tablets. capsules

.rl,!,,!:rl lr,;rrttl.
|'

r ;r

rr

r;

rr't'r

ical Packaging Technology : Selection and evaluaf i'x

packaging rnaterials, contaillers and clcsures,

,,t t,ir'r, rrr,rr't'ulical

.1,r

ol

r:ontainer-product interactions, pharrnacopoeial

, rtii ;rtron.r. lest and standards for packaging materials.
lrr,lrr'.tr r:rl Salbty: Industrial hazards and their prevention, fire,

i'i,,l,i'

1rr'.

.,,, q,1,
'r,, rrrt'clnrtical and eleetrical ecluipments, industrial effluent
r. t,i,r, .rrr,l lrr.;lltttcttl.

ltr.t.r'lrnology. Introduction, importance and application of

kinetics, enzyrne inhibition,
and
i,!r'rrrrr;rr ('iilr('irl rrlrplications of enzymes, immobilizatictn of cells
. ii:.i iti, . .rpplicrttion of immobilization. immot,ilization in design of
,,, ', i ,lrr,1, ,lt'livcry systems and drug targeting"
I r . ,rrt ( rrllrrrc: lntroduction, types of cuiture, micropropogation,
1,i,,r,,1,1,r.! iirri'roirr-icction, plant tissue culture, aninlal cell culture,
1,!r,riirr;r, , ritit::rI lliotochnolog)', enzyme

i,l!:r ! ! r:r, i ilrr ;r I irliplications of plant and auimal tissue culture, prcductiol)
, ! ' ',r.rir{ i( r:rll-\' trsef ul compounds by plant cell culture" biori=iii !,,r rrr.rtrorr lrl lriglter plant cell culture. grnwth ol'cell in bioreactor
tissue culture based
=l,,,1 1,r',rlrit tr.rr ol'active principles, bioreactot,
rrr.rr
,
rrl
t,
;tl
irrtlrtslrics.
1r
1,1,
r

!i, , , inrlrrrriurt l)NA T'eclrnology and Genetiss: Basic cotlcepts of

,
lri r l,r,'ri !n syrrllrcsis and targeting, genetic recornbination, gene
!i:,r, !, r rrr, !llorls irr prokaryotes and eukaryotes, tocirttiques eif'g,cnetic

26

Eylltlns:Mnsterof

RaiasthanllniausitY ofHealth

i,utrl r ol lctl rclease, irnplants.

M'Pharrn (Pharmaceutics)
Second sernester
M.PII.123T Novet Drug Delivery System, Theory 60
Polymers and their Applications in Development of N
lntroduction, basic properties ofbiodegradable and non
pol3rrners and their uses.
Sustained Release Drug Delivery System: Principle i

Irrllnvaginal and Intrauterine Drug Delivery Systern: Introduction,

vugrrrnl corrtraceptive ring, medicated IUD, copper IUD, hormone
relearirrg ItJD.

M.t,Il.t24

Novel Drug Delivera

System,

90

XIrs.

Practical
('lrnrroterization of given polymer such as viscosity, molecular
petghl rrnrl glass transition temperature.
Iivrrlrrnlion of drug free polymeric films.

advantages and disadvantages, dose considerations, physica

lir:vitro characterization of transdermal patches of given drug.

l)s:ypl11p11ent and evaluation of ocular inserts of given drug.
l"orrrrrrlalion and evaluation of floating microspheres.

and biological properties of drugs relevant to sustained

fonnulation, niicro eneapsulation, evaluation and stability studiee
SRDF.
Oral Controlled Drug Delivery Systems: Principle involved,
concept, osmotic pressure controlled, membrane permeation
pF{ independent, iorl exchange, controlled gel diffusion, controlled
hydro dynamically balanced systerns, evaluation.

Mucosal Drug Delivery System: lntroduction, anatomy

ph3,siology of oral rtucosal, meehanisrn of transrnucosal
and mucous membrane models, buccal, nasal, pulmonary
vaginal, drug clelivlry systems. delivery of peptides
pharmaceuticals.

liorrnulalion and evaluation floating tablets.

l'r eprrnrtiorr and evaluation of buccal filrns of some cardiovascular
tlt

ttgt

lnsle nbatement of some bitter drugs by ion-exchange resins.

I'rcpnration and physico-chemical charaeterization of

ffilltrre nltsrrlcs of given drug.
l)cve lopment

and evaluation

of

osmotically controlled drug

rlcllvrr\ sy\tcm.
Slrrrly of cl'fect of solubility enhancers on diffusion of poorly water

Transderrnal Drug Delivery Systein: Fundamentals oftra

permeation and factors affecting it, permeation enhancers, deve
of transdermal drug delivery systems, evaluation and

lrtlrthlc rllrrgs.
I'rt-prrralion and evaluation

deveiopments.

of muco-adhesive rnicrospheres.

l'r c ru rlt ion and characterization of wax embedded microspherules

tlrtrgs.
gtvsir
Ef
Itlcpnrnlion and characterization of- (a) liposomes (b) niosornes
1

Targeted Drug Delivery Systems: Principles of targeting,

s

such as liposomes,.aquasomes, niosomes, pharmacosomes, dend

and particulate carrier systems such.as nano particles, micro
modified micro splteres. solid lipid nano particles (SI-N), liquid
resealed erythrocytes, monoclonai antibodies, interaction of col
delivery systems rvith biological environrnent, surface modificat
colloidal drug delivery systems.

Farenteral Drug Delivery Systern: Basic concepts and ap

27

trr lrnrerrterals, controlled release of drugs, formulation of parenteral

engineering, applications of recombinant DNA technology in

vaccines, hormcnes production, genetic disorders and gene

of targeting preparation and evaluation of vesicular carrier

Phntmflcy

(e) ttttttolurrliclcs

il,ltll.lls'l'
Il

Biopharmaceutics and
Pharmacokinetics, Theory

50 t{rs"

Alrsorption: Gastrointestinal absorption of drugs, mechanism

rs,rrption, physico-chemical, biological factors influencing
rt1rl rurr, lrrrccal absorption, salivary excretion of drugs.
rrpr

dt'trpr nl

! lrrrp',

l)islribution, Biotransformation and Excretion: Factors

A?'niust"nnn"t*mir:msifu a, WnesitfuS$ences

?B

g drug distribuiion,'rolurne of tli stributi*t'i' prctein trind'irlg'

cting it, renal and rlonin*chanisln of iriiltransf'onnaticn nrtcx, iactors:rf
kinetics'
rena! ,;xcretic;l, eoncept of'ciearanee and

effg^.:i

it.i

f,actcrs lnfluencing
tsioavailabilit}.:fild Ei.:eqLeivalence: lntroductiorr,
<iesigrling the study
bic,availability methods to determine bioavailability'

ilr-vitro-and infor assessm*rrt of biouuailability and bioequivalence'

of bioavailabiliry methocis to enhance bioavailability,
"orr"fution
"lro
statistical concepts.
Pharmacokinetics:Basicconsiderationof,one,twtrandmultiple

compartnrentrrroeielsincludinglV-boltrs,IVinf.usionandextra
dosing' dosage regimen
vassular adn:rinistration, kineties of multiple
(loading and rnaintenance dosages)
distribution and
Clirricatr Fharmacokinetics: Concepts, absorption,
disposition and
renal excretion, hepatic clearance and elimination'
regirnen' therapeutic response and
absorption kinetics, therapeutic

toxiciry dosage regirnen, clinical based studies'

physiologic
Physiologic Fharmacokinetic Models: Basic concepts'
diffrusion
versus
pharmacokineiie rnodel with binding, blood florv-limited

ii-it*d *od"l, application and limitations of physiclogic pharmacokinetic

absorption time (MAT) and
rnodels, *"rn r*iid"nce time (MRT), mean
rnoment theory (sMT)'
mean dissolution time (luD'f), statistical
non-linearity' one
Non-I-inear Phannaeokinetics : Recognition of
Kinetics,
and two cOnnpartrnent open model ivith Michaelis_Menton
constants'
binding
tissue
detennination of km, Vmax" nonlinear
of computers
Applicatinns of Computer: Introduction' applieation
in pharmacokinetics antl biostatisties'