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E.O,F.fi:XAMTNATION

:AI$ ,CoUR$E$ O.F'STU[}Y

Faculty of Health Science

rvl- PFJAIIIM_

I Semester Examination, 2008 lll Semester Examination, 2009

ll Semester Examination, 2008 lV Semester Examination,2009

d

,s

V

,Price : Rs.23.00

H-If FOGK EEPSE

opP, TADKE$HWAR TEMPLE,

'1s7,

$HAURA RASTA, JAIFUR

TTAJASTHAN UNIVERSITY OF

HE,A.I-TH SCIENCES JAIPUR

SYLLABUS

SCHEME OF EXAMINATION AND

COURSES OF STUDY

FACULTY OF HEALTH SCIENCE

M. Pharm.

First Semester Examination

Second Semester Examination

Third Semester Examination Fourth Semester Examination

SHTV BOOK T}trPOT

Opp" Tadkeshwar Temple, 167, Chaura Rasta, Jaipur

O Rajasthan University of Health sciences Jaipur

Publtshed b1' Shiv Book Depot, Jaiput

for University of Rajasthan

Printed by Harihar Printers,

Jaipur

lypc Sctting M.M. Computet & Graphics, Jaipur

Sy llab us : M a st er of Phammcy

MASTERS DEGREE IN PHARMACY (M.Pharm) ACADEMIC REGULATIONS

l.

Duration of the course

The duration of the M.Pharm course shall be of two academic

years (four semesters). The cour'se of study for M.Pharm shall

include first semester, second semester, third semester and final

semester, each of 15 weeks duration (excluding days spent in

examination).

2.

Etigibility for admission

2.1

A candidate who has passed B.Pharm with at least 55% marks (Aggregate of 4 years i 3 years for lateral entry admission) (for

SC/ST candidates, the pass percentage at the qualifuing

examination) from an institution approved by PCI and AICTE.

2.2

Preference will be given to GATE qualified candidates.

2.3

For sponsored candidates

A Pharmacy Graduate, fuifilling conditions mentioned in section

2.1 and having 2 years of full time professional experience in

a registered pharmaceutical companyl educationai and/ or

research institution/ any govemment organizaticn shall be eligible

for admission under sponsored category.

Sponsored candidates shall have to submit a sponsorship letter fiom their employer along with the application forrn for admission.

The letter must also mention the length ofcandidate's cmployment

with the sponsor and the undertaking that the sponsorship shall

not be withdrawn before the completion of the course.

Sponsored candidates shall not be eligible to receive scholarship,

even if they are admitted on the basis of GATE score.

2.4

There will be no age restriction. However, candidates below 45 years of age shall be preferred.

2.5

Admissions will be made in order of merit. For preparing merit, equal weightage shall be given to aggegate percentage of marks

obtained in B.Pharm and GATE.

Reservations will be made as per State Govt. / University rules. In case ofnon availability ofreserved category candidate(s), the

reserved seat(s) shall be filled up by general category candidate(s).

+

a

Rajasthan llniausity of I lealth S ciences

Scheme of StudY & Examination

3.1 The medium of instruction and examination slrall bc Bnglish.

J.L aa

Candidates for the M.Pharm course shall be instructed ancl

examined as per the Teaching and Examination Schcme and Course Content of respective specializations'

4. Eligibility for appearing in the examination

4.1 Attendance Requirement:

examination, a student

In order to be eligible for University

ol

must be present in not less than 75

of theory and practical classes of each subject'

4.2

4.3

4.4

A candidate who has attended a regular course of study for the

first semester

ufp"u. at

University.

in an academic institution shall be eligible to

the M'Pharm first semester examination of the

A candidate who has been promoted to second semester as per

the provisions for conditions of passing and has attended a

."goiu,

of study

in an academic institution for the second

seirester

"ourse

shall be

eligible to appear at second semester

examination for M.Pharm.

A candidate who has been promoted

academic

passing

io the

institution as per the

to third semester in an

provisions for conditions of

and has completed the dissertation research work up

satisfaction of the superuisor as prescribed under the

relevant regulations for third semester shall be eligible to appear

at the third semester examinati':n for M'Pharm'

4.5

Atthe beginning

of M.Pharm' third semester, for each candidate'

supervisor shall be appointed by the head ofthe

institution. The candidate shall choose a topic for dissertation

in consultation with the supervisor' carry out literature survey

on the propoSed dissertation topic and submit a dissertation

a dissertation

synopsis including to tne UeaO of the

then carry

dissertation topic at the institute running the course under the

out the dissertation research work on the approved

institution for approval' The candidate shall

plan of work duly signed by the supervisor

guidance of respective

i"rfo.m

his/ her

supervisor' A candidate may also

dissertation work at any other institute/

iaboratory/ industry as per the reqttirelnent oi'the subject on

Syllabus: Master of Pharmary

approval ofthe supervisor and the head ofthe institution. Ifthe

appointed supervisor leaves the college/ is likely to be absent

for a long period, the head of the institution s'rall appoint another

sufervisor. The candidate shall continue the dissertation work on the topic approved earlier.

4.5 A candidate who has been promoted to final semester as per the provisions for conditions of passing and has completed the dissertation research work up to the satisfaction ofthe supervisor

as prescribed under the relevant regulations for the final

semester shall be eligible to appear at the final semester examination for N4.Pharm. During M.Pharm. final semester, candidate shall continue the dissertation research work of the

third semester.

5" Sessional (Internal assessment)

5.i Theory sessionai (25 rnarks):

Written test

:

15 marks

Seminar and/or assignment :

l0 marks

Total

:

25 marks

(i) Written test (15 marks):

At least two written tests of 15 marks each in every theory

subject shall be conducted by the institute at regular interval during each semester. The average of best two

performances shall be taken into consideration for the purpose of computation of corithen test marks' Duration of each written test shall be of one hour.

(ii) Seminar and/ or assignment (10 marks):

Every student shall present a subject seminar and/or

submit assignment on the topic assigned by the subject teacher.

5.2 Practical sessional (25 marks):

Practical

test

:

15 marks

Day-to-day practical work :

l0 marks

Total

:

25 marks

(i) Practical test (15 marks):

At least two practical tests of 15 marks each in every

Raj asthan lJniaersil:y of H eulth S ciences

practical subject shall be conducted by the institute at

regular interval during each semester. The avorage of best

tWo performances shall be taken into consideration fbr the

purpose of computation of practical sessional marks' The duration of each practical test shall be or'6 hours. Each

practical test may be conducted in different pafts viz'

synopsis/ spotting, exercise/ experiment and viva-voce

etc.

(ii) Day-to-day practical worV experiments performed

(10 marks):

The concerned teacher shall evaluate the dayto-day

practical work/ experiments performed in the laboratory

on the basis of the performance of the student' viva-voce

and maintenance of practical record'

5.3 Professional practice:

The students shall carry out professional work as allotted by the

head of the institution in M.Pharm. first and second semesters'

The professional work shall include perforrna,rce of lab. dttties,

analysis of samples etc.

5.4 Dissertation sessional (50 marks):

For M.Pharm. third and final semester dissertation sessional, the

candidate shall submit a copy of dissertation progress report

printed or tlpe written, containing the results of hisfter dissertration

research work duly signed by the supervisor and forwarded to

the head of the institution, on or before the prescribed date.

The evaluation shall be on the basis of serninar and dissertation

progress report, presentation and viva-voce and shall be done

ofdissertation supervisor and one teacher

by a board consisting

of the subject.of specialization (to be appointed by the head of

The average of the marks awarded by the board be considered for the purpose of computation of

members shall

the institution).

dissertation sessional marks.

5.5 The record of marks of sessional examination for each student

shall be maintained by the academic institution and must be submitted to the University before the commencement of

University examination.

Syllabas : Master of Phannacy

s.6

A candidate failing in uny of the subjects shall have a chance

to improve his /her sessional marks in theory practical and

disserlation by appearing in one additional sessional examination.

The aggregate of best two performances from all the sessionals

shail form the basis of calculating the average far computation

of irnproved sessional marks. Marks for day-to-day assessment

in the practicals cannot be improved unless a candiclate attends

a regular course of study again.

University examination

University examinations for all the four sernesters are to be held twice in a year, as per the Teaching and Examination Scheme and Course Content, in the months of Dec.lJan. and June/July

or on such dates as may be fixed by the University.

6.2 University examination in each theory subject shall be of three

hours duration" There shall be 7 questions carrying equal marks,

out of which 5 questions shall have to be attempted.

6.3 University examination in each practical subject shall be of 6

hours duration and shall cor-nprise of synopsis / spotting, exercise

/ experiment and viva-voce etc. The head of the institution shall send the awards to the Universiry on or before the prescribed

date .

7. Dissertation

7.1 For M.Fharm. third semester Universiry" examination, the

t.2

candidate shall subrnit four copies of dissertation report, printed or type written, in spirally bound form, containing the results of

his/ her dissertation work duly signed by the supervisor and

countersigned by the head ofthe institution.

l'he evaluation shall be on the basis of dissertation report, presentation and viva voce and shall be done by a Board

consisting of dissertation supervisoq external examiner appointed

by the University and the F{ead of the institution who shall be the chairman of the board.

The chairman shall then send the awards to the University, on

or before the prescribed date.

For M.Pharm final semester University examination, the candidate

shall submit four copies of dissertation thesis printed or type

8

8.

8.1

8.2

8.3

llaiasthanllniaersity of Health Sciences

written, in bound form, containing the nesults of lris/ her research

work. The dissertation thesis shall bear a certificate from the supervisor countersigned and duly forwarded by tlre Head of

the institution, on or before the prescribed date, certifoing that:

(i) the work has been undertaken and cornpleted and the

dissertation has been written under his/ her superttision

and guidance and meets the requirements uf the course;

(ii) the dissertation is a bonctfide record of the original work

carried out by the candidate and the di-ssertation work

has not fornted the basis of award of any other degree or diplorna etc. of this or any other University.

The evaluation shall be done on the basis of dissertation thesis,

presentation and viva voce and shall be done by a Board

consisting of dissertation supervisor, external examiner appointed

by the Universitv and the Head of the institution who shall be

the chairman of the board. The chairman shall then send the awards to the University, on or before the prescribed date"

Conditions of passing

A candidate shall be declared to have passed irr a sub.iect when

he/ she has secured 50% of the maximum marks in the sessional

and University examination marks put together separately in

each theory and practical sub.jects and dissertation sessional and

dissertation university examination.

A candidate who fails to obtain 500/o marks in any subject(s) (Theory and practical counted as separate subject) in first or second semester examination, shall be eligible for promotion to second/ third semester. Such candidate shall have to appear again in failirig subject(s) in the subsequent examination'

No candidate will be eligible

unless he/ she has

semester.

for submitting the dissertation thesis

passed in all subjects of firs# second

8.4 A candidate, who has failed in M.Pharm third semester

examination, shall be furnished by the Board with a clear

statement of reasons for failure and suggestions for improvement' He/ she shall not be allowed to pursue course for M.Fharm final

S y llabas : M ast er of Phavmacy

semester. He/ she shall revise and resubrnit the dissertattotl

report after pursuing research vvork as suggested by the board

on the same dissertation topic. Sucli a candidate will have to reappear as an ex-stuCent in the next M.Pharm third semester

U niversity exam ination.

8.5 A candidate, who has failed in M'Pharm final semester

examination, shall be furnished by the Board [Point 6(d)] with

a clear statement of reasons for failure and suggestions for improvement. He/ she shall revise and resubmit tlie disseftatioir

thesis after incorporatin. suggestions made by the board on the

same dissertation topic. Such a candidate will have to reappear

as an ex-student in next M.Pharm final semester University

examination.

8.6 In no case shall a candidate, who has not passed finally after

six academic years from the date of enrolinent, be ailowed to continue the course.

The Vice-chancellor in consuitation with the Head of the

institution -;ray waive this limit of six academic years. The

reasons for waiving the limit shall be recorded in writing. Sucli

extension shall not exceed one year.

8.1 A candidate who is unable to appear at any examination in any subject(s) due to any reason whatsoever shall be considered as

having failed in that subject(s).

9. Award of I)egree, f)ivision and Rank

9.1 On satisfactory cornpletion of the course and after passing all

the semester examinations. a candida-te shall be awarded degree

of M.Pharm in the respective branclr.

9.2 No division shall be awarded at tlie end of Vl'Pharm first,

M.Pharm second and M.Pharm third semester examinations.

The division to a successful candidate shall be awarded on the basis of aggregate of marks obtained by him/ her in M.Pharm

first semester, M.Pharm second semesteq M'Pharm third

semester and M.Pharm final sernester examinations regardless

of the number of attempts. as shorvn belon':

Percentage of marks

75Vo or above

Division

Honours

L0

9"3

OA

9"5

Raj asthan Uniaersity of Health Sciences

60%* or above

50% or iibove

First l)ivision

Second Division

A candidat"e will be said to have passed a paper with distinction

if ire/ she secure 75Yo or more marks in the concenred paper'

'Ihe actual marks (and'not the passing marks) as obtained by

a candidate in a supplementary/atternpt examination shall be counted for award of division.

Rank and university gold rnedal.shall be conferred to those candidates rviro have passed the whole examination in fir:st

attempt (without any grace) and such candidates shall be eligibie

for any prize or scholarship.

S y ll nbus : M ast er of PharmacY

L1

Teaching & Exanninaticn Scheme

M.Pharm (Pharrnaceutics)

First semester

Paper

Subject

No.

M.PHIl3T

Research, Theory L{ethods in Pharrnaceutical Research, Practical Product Devclopmenl.

M.PI{l l,lP

M.PHl I5T

Theory

Product Development, Practical Advanced Pharmaceutics

& Biotechnology, Theory

ProfesSional Practice

Teaching

hrs. per

week

4

6

4

Univ.

exarn.

Marks

Sessi Univ. Total

hrs.

onal Exam

3

75

6

75

J

25

'ts

6

x

75

J

75

 

:

100

100

100

100

100

Total

* These hours will Second semester

36

t2s 375 500

not be counted as workload of Teacher.

Papcr

No.

Subject

Teaching

hrs. per

week

l-lniv.

Marks

exam. Sessi Unir'. Total

hrs. onal Exant

M.l22P

M.Plil23T

M.Pl-ll24P

M.PI-II25T

Advances in

Pharmaceutical Sciences including Biostatistics, Theoqv

Advances in

Pharmaeeutical Sciences including Biostatistics,

Practical

Nnvel Drug Delivery

Systern, Theory

Novel Drug Delivery

System, Practical

Biopharmaceutics and

Pharmacokinetics,

Theory

Professional Practice

Total

6

4

x

.)

23

75

i00

?5

75

)

25

i5

tfn

6

25

75

100

1

100

 

:,:

125

375

500

* 'l'hese hours

not be counted as workload of Teacher.

12

Third semesten

Paper

No"

Subject

M.PH2I lD Dissertation (Report,

Presentation &

Viva-voce)

Finatr semester

Faper

i\o.

Subject

M.PFD2lD Dissertation (Thesis, Presentation &

Viva-voce)

Ra! asthan Unia ersity af Health S ciences

Teaching

Marks

hrs. per Sessional Llniv.Exam Total Week

'K

50

Teaching

150

Marks

200

hrs. per Sessional Univ"Exarn Total

%

50

150

200

f-

7J

:Mast*of PhaflnacY

19

,Pltgrrn

"uruoru.

lrr l

COURSE CONTENT (Pharmaceutics, Pharmaceutisal chemistry, Quality

lrharmacolory, Pharmaceutical Managernent and Regulatory

COMMON SUBJECTS

lcmcster

,11 l'[

Methods in Pharmaceutical Research,

Theory

60 IIrs.

UV-Visible spectroscopy: Brief review of electromagnetic

r. l,J V -V i s ible range, enerry-wavelen gth--co lor relationships'

tion ol'electro--magnetic

radiation (uv-vis) and matter and its

Itt, chromophores

lrn ol' organic

and their interaction with E.M.R. Absorption

compounds and complexes illustrating the

of

,u,, ornd its utilization in qualitative and quantitative studies

rtrills and their interpretations (including solvent effects); photo-

lc spcctroscoPY.

Itrl'ra-Rod spectroscopy: Nature of LR. radiation, interaction of

H{latiorr

lAfla-roU

with organic molecules and effects on bonds, molecular spectra, brief outline of classical I.R. instrumentation and

ifgfr:tnti()n

tlve

of spectra including sample preparation for spectroscopy,

irrterpretation of I.R. spectra, quantitative methods and

Htlvtutces in I.R. spectroscopy including FTIR, ATR, etc'

Nrrcleur Magnetic

lpler ol'NMR

Resonance spectroscopy: Fundamental

(magnetic properties of nuclei: applied field and

on: atrsorption and transition frequency), ctremical shifts

. lirr:tors affecting chimical shift, isotopic nuclei, reference

I l)roton magnetic spectra, their characteristics, presentation,

unerl in describing spectra and their interpretation (number

and irrtcnsity of signal), briefoutline of instrumental arrangements

details, signal multiplicity phenomenon in high

t0rtrc proctical

lUtlun i,MR; Spin-spin coupling, application of signal splitting and

Ittg constant data to interpretation of spectra, proton exchange

lon;, clecoupling and shift reagent methods"

Briel'outline of principles of FT-NMR with reference to r3C-

I Spin-spin and spin-tatticerelaxation phenomenon, free induction (lilt)). proton noise decoupling, signal averaging tirne domain

20

Rajasthan Unia er sity of H ealth

and frequency domain signals, nuclear overhauser enhanceme

NMR spectra; their presentation, characteristics, interpretaticn,

and applications.

Brief indication of application of, magnetic resonance

data of other nuclei by modern NMR instruments, introduction

D NMR techniques.

'

Mass Spectrornetry: Basic principles and brief outli

instrumentation, ion formation and types; molecular ions, rneta ions, fragrnentation processes' fragmentation patterns and characteristics in relation to parent structure and functional relativb abundances ofisotopes and their contribution to cha

peaks, mass spectrum; its characteristics, presentation and i

chemical ionization rnass spectrometry GC-MS including

advances in MS, Fast atom bombardment mass spectroscopy;

of drugs in biological sarnples by combined GC- MS.

Chromatography: Basic principles, instrurnentation'

techniques and quantitative analysis of drugs and their

using column chromatogaphy, paper chromatography, TLC,

exchange chromatography, GC, GLC, HPLC and HPTLC.

Electrophoresis: Moving boundary electrophoresis,

electrophoresis, iso-tachophoresis, iso-electric focusing and electrophoresis.

Flourimetry and chemilumniscence: Principles, inst and applications; electro-chemiluminescence' resonant ionization

I-aser-enhanced ionization.

X-ray crystallography, thermal methods of analysis, DSC,

eto.

M.X12P

Methods in Fharrnaceutical

Practical Experirnents $ased on calibration and

Researeh,

validation of a

Qualitative and quantitative analysis cf phannaceutical

and dosages having single component or in combination of foll categories: (biological and microbiological methods excluded)'

i) Alkaloids ii) Antibiotics iii) Steroidal homones iv) Vitam

Barbiturates vi) Sulfa drugs.

tyllalun: Nlnster of Phalmqcy

2\

ll.V./ Visible spectrum scanning of certain organic compounds,

of

structures, comparison €.8.,

chrnrltliotr and correlation

€ltftrraltpltctricol,

efter't ul' pll

analgin, paracetamol, sulphadiazine, Ibuprofen etc.,

and solvent on UV spectrum of certain drugs.

liclinrntion of single drug (raw materiaV formulationg) by colorimetry

lnvnlving dif ferent reagents.

Doterrnination of UV cut off wavelength for different solvents. Firtinrution of single drug (raw materiaU formulations) by W

lFotr(ll)hotometry.

Slrnultaneous estimation of paracetamol and ibuprofen and other flg;nhirrntion formulations by W spectrophotometry using simultaneous ffl$et [rrrs/ derivative spectroscopy/ multiwavelength spectroscopy etc.

('untpnrison of three different analytical methods for salbutamol

ffi ulltor drugs.

('alibration of IR spectrophotometer using polystyrene film and

Sheehhrg thc performance of the instrument.

Recording IR spectra for known drugs and comparing with that

ff Phanrrucopoeia, estimation of drugs using lR. lR rpectra of simple molecules and interpretation of the same.

E:tiuration of drugs bY flourimetry.

, llrtinration of drugs by flame photometry'

Strur.:tural elucidation of at least 5 unknown compounds using UV,

NMR and Mass spectral data'

ltl'f

iemester Advances in Pharmaceutical Sciences including Biostatistics, TheoIa

60 Hrs.

Blrutatistics: The application of the following in pharmacy shall

gnvorod,

MEan. nredian and mode, standard deviation and coefficient of

lorr. students t-test, one way ANOVA, chi-square test, probability,

y distribution, regression analysis, bioavailability-cross-over , Wilcoxon signed rank test, introduction to control charts.

Phanr ur i n l'ormatics : lntroduction to information resources available

th lulernct for the various subjects in pharmacy.

22

Rai'asthunllniaersitg ofHealth

Experimental Designs : lntroductiorrr to fu l l factorial desi gns, centr

of full antdreduced mathematical rnod'e

designs,

"ornporin"

in experimental designs,

the subjects

contour Plots. Patents: Definition, need forpatEnlting' types of patents' conditi

tobesatisfiedbyaninventiontobepatentable'introductiontopa

search. The essential elements of patent;;; Guidelines for preparation

mentioned "na"t pharrrnainformatics'

"uJlution

.---r:^^!:^-^

applications

oof the experimental

^^f

tha

pwnerirncnfsl

desiEnS fi

designs

introduction

notebook, non obviousnegs in. patent'.drafting

laboratory

claims,

imporant patent related web-sites, brief introduction to

.of ,1at

protection and WTO Patents.

lntrocluction to 'The Patent Act I '970' as amended in 1999'2

&2005 and the rules made there und@r, with special emphasis on

forms to be submitted along with a patent application'

evaluation of the foliovwing classes of drugs: analg

anti-inflammatory agents, tranquilizers, hypoglycemic agents and di

Biological

agents.

Introduction to various stages ir:r process of drug develt

scope and aims of preclinical and clirnical trials for drugs and

forms.

methods for evarluation of crude drugs' mono

"th :.ilY

Pharmacopoeial

po lyherbal

'"i*u"iin.

formulation s by F.O' M' deaterminatig'n' L,O' p''

value, phyomorphology, mfi croscopial methods' quantitati

microscopy,

determinaiion and evaluation uy otherr advanced methods

quafit;tive analysis, pest:'icide analysis'

Ti":"|:"t .":it:

like uv,

GLC, HPLC, TLC, & HPTLC etc'; automated analysis

aided Analysis.

Drug Stability:

Solution stability, solid stability' parameters

physical itability

testing, protocol for physical stability testing p,rogr

accelerated studies and shelf life as:stgnment'

M.l22P

Advances in Pharrirrceutical Sciences

90

including Biostatistic:s' Practical

Animal experiments for deterrmination of activity' potency

toxicity of drug substance and doszuge forms'

Parameter