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  • Seven - Jan. 2015

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    Nephrology On-Demand
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    Seven_ Jan. 2015

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    Seven_ Jan. 2015

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    Seven_ Jan. 2015

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    647 visualizzazioni2 pagine

    Seven - Jan. 2015

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    Nephrology On-Demand
    Seven_ Jan. 2015

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    © All Rights Reserved
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    Segnala contenuti inappropriati
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    onbueae: Age at asa | PD Sauer |matphaeceev aan ey 5 ication exclusively or medical students and residents Stay connected with us through the in Interna! Meine by Nephrology On-Demand NOD Pus App: hnp://g00 giAiSAQT NEW YEAR...NEW YOU...AND A NEW TARGET AGAINST AN OLD FOE ‘As we start 2015 with new goals and renewed personal NEPA een plagued with commitments to accomplish our goals, we begin Issue 7 with a fresh angioedema because of an excess in bradykinin effect. But look at new target in the battle against kidney ditease. For decades _nephrologists have begun to testa diffeyent combination: ARB + nephrologists and physiologists have foc (conveniently known as ARND which have a more favorable ngictensin~aldosterone (RAS) axis a fect profile Senn unkcws wage tet lerating kidney disease, Regardless of the etiology (be it diabet swell probably enfin 2016 kidney disease or lupus glomerulonephritis), the common destructiv is. In fact, this belief has been around of you, the i | 252-082 seid win culprit for so many years (dare I write. decades), that for sox RAS~axis has been the only culprit of kidney disease that you've ever known! As we begin 2015 with a new 1 kidney disease, we fist . jon tothe new “bad guy" in the neighborhood: neprilysin. Also me :nown as peutzal endopeptidase, NEP isan enzyme fourd in huge ox concentrations in the proximal tubule, Its modus operandi (MO) isto wwe the 3 main types of natriwetic peptides (aptly named BNP, and CNP), ic peptides are secreted either by cardiac myocytes (ANP & BNP) or by endothelial! cells (CNP) to increase renal excretion of sodium (Na") in the setting of hypervolemia, Asin real fe, NPe are lfe-savers when you're drowning The natri nean..when ‘you're drowning in salt, NEP accelerates the destction of NPs rendering them useless and ps jon of Nat, especialy in

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