1.

Basic Science and Structure of Skin

# Question MCQ A
1 Pick the correctly paired keratin
with its structure:
1. K1K1! " #asal cells
$. K%K1$ " esopha&us
%. K'K1% " cornea
'. K(K1' " supra#asal cells
(. K1)K) " pal*s and soles
+
$ ,hich of the followin& state*ents
a#out the direct
i**uno-uorescence pattern in
lichen planus is correct.
1. /he 012 is ne&ati3e in the 3ast *a4ority of
cases
$. 0eposition of 1&5 is within cytoid #odies in
the super6cial der*is
%. /he 0+7 deposition is &ranular
'. 0eposition of 6#rino&en is within cytoid
#odies in the deep der*is
(. /here is pro*inent deposition of 1&M within
the spinous layer of the epider*is
C
% Krause end #ul#s are: 1. Adaptin& *echanoreceptors found on
wei&ht"#earin& sites that respond to 3i#rational
sti*ul
$. 2ound on the 3er*illion #order of the lips
%. 8ocated in the der*al papillae of di&ital skin
'. 8ocated in the deep der*is and within the
su#cutis in wei&ht"#earin& sites of the #ody
(. 2ound at the ori6ce of the hair follicle and
particularly sensiti3e to cold
B
' 9n electron *icroscopy: which cell
de*onstrates cytoplas*ic
pro4ections and secretory
&ranules.
1. 8an&erhans cell
$. Keratinocyte
%. Mast cell
'. Melanocyte
(. Macropha&e
C
( ,hen do *elanocytes #e&in to
synthesi;e *elanin.
1. $nd *onth of &estation
$. %rd *onth of &estation
%. 'th *onth of &estation
'. (th *onth of &estation
(. )th *onth of &estation
B
) +pider*olysis #ullosa si*ple<
=+BS>: ,e#er Cockayne type: is
caused #y what defect.
1. Colla&en ?11
$. Alpha")"#eta"' inte&rin
%. Keratins 1 @ 1!
'. Keratins (
(. Plectin
0
A Mutations in which of the followin&
proteins results in epider*olysis
#ullosa si*ple< associated with
*uscular dystrophy:
1. Bncein
$. Plectin
%. a)#' inte&rin
'. 8a*inin (
(. Colla&en type 1?
B
C S1!! stainin& would #e ne&ati3e
in.
1. lan&erhans cells
$. eccrine cells
%. schwann cells
'. adipocytes
(. keratinocytes
+
D 0irect i**uno-uorescence is of no
3alue in the dia&nosis of:
1. Eeonatal 8+
$. 8ichen planus
%. Mi<ed connecti3e tissue disease
'. S8+
(. +rythe*a *ultifor*e
A
1! /he *a4or co*ponent of the
anchorin& 6la*ents is:
1. Bncein
$. Plectin
%. a)#' inte&rin
0
1
'. 8a*inin (
(. Colla&en type 1?
11 Fair &rows at: 1. !.!!' **day
$. !.!' **day
%. !.' **day
'. ' **day
(. 1! **day
C
1$ 2ra&*entation andor loss of
elastic 6#ers in not seen in:
1. Cutis la<a
$. MarfanGs syndro*e
%. Anetoder*a
'. Psuedo<antho*a elasticu*
(. Buschke"9llendorf Syndro*e
+
1% Se#aceous &lands secrete se#u*
throu&h which of the followin&
secretory *echanis*s.
1. Folocrine
$. Merocrine
%. Apocrine
'. Folocrine and Merocrine
(. Folocrine and Apocrine
A
1' ,hich of the followin& is true
re&ardin& the de3elop*ent of hair
follicles.
1. /he 6rst pri*ordial hair follicles for* at 1(
weeks &estation
$. /he 6rst hair follicles for* on the scalp and
eyelashes
%. 2ollicles de3elop in a cephalad to caudal
direction
'. Eew follicles de3elop durin& the 6rst %
*onths postpartu*
(. /he eye#rows de3elop late in &estation
C
1( /he proteins that *ake up the
corni6ed cell en3elope are
synthesi;ed in the:
1. Stratu* corneu*
$. Stratu* #asale
%. Melanocytes
'. Stratu* &ranulosu*
(. 8an&erhans cells
0
1) Keratin 6la*ents in #asal cells
insert into:
1. 0es*oso*es
$. Adherens 4unctions
%. Conne<ins
'. 8a*ellar &ranules
(. 9dland #odies
A
1A ,hich of the followin& state*ents
is true a#out eccrine &lands.
1. Post&an&lionic sy*pathetic 6#ers with
acetylcholine as the principal neurotrans*itter
$. Post&an&lionic sy*pathetic 6#ers with
norepinephrine as the principal neurotrans*itter
%. Post&an&lionic parasy*pathetic 6#ers with
acetylcholine as the principal neurotrans*itter
'. Post&an&lionic parasy*pathetic 6#ers with
norepinephrine as the principal neurotrans*itter
(. Post&an&lionic sy*pathetic 6#ers with #oth
norepinephrine and acetylcholine as the principal
neurotrans*itters
A
1C Hed or #londe hair pi&*entation
pri*arily results fro*:
1. /he presence of eu*elanin
$. /he a#sence of *elanin
%. /he presence of pheo*elanin
'. /he reduced acti3ity of tyrosinase
(. /he reduced acti3ity of 09PA dehydro<ylase
C
1D +ach of the followin& is true a#out
*elanoso*es e<cept:
1. Most characteristic or&anelle of the
*elanocyte
$. /yrosinase acti3ity decreases as
*elanoso*oes *ature
%. Are transferred to keratinocytes 3ia
pha&ocytosis
'. Are sin&ly dispersed in the #asal layer in
white skin
0
$
(. Are lar&er in si;e in #lack skin co*pared to
white skin
$! /he *icro-ora of pilose#aceous
unit consist of which of the
followin&:
1. Pityrosporu* o3ale
$. Staphylococcus aureus
%. +scherichia coli
'. Pseudo*onas aeru&inosa
(. Coryne#acteriu* diphtheriae
A
$1 ,hich protein is the lar&est
co*ponent of the corni6ed cell
en3elope.
1. Keratin
$. 1n3olucrin
%. Pro6la&&rin
'. 8oricrin
(. Cera*ide
0
$$ Apocrine &lands are found in all of
the followin& areas of the #ody
e<cept:
1. A<illae
$. Breasts
%. +yelid
'. Pal*s
(. Perineu*
0
$% ,hich type of colla&en in *utated
in osteo&enesis i*perfecta.
1. Colla&en 1
$. Colla&en 11
%. Colla&en 111
'. Colla&en 1?
(. Colla&en ?11
A
$' /he 6ndin& on 012 that re-ects
#indin& of the Ho and 8a anti&ens
in su#acute cutaneous lupus
erythe*atosus is:
1. 5ranular -uorescence throu&hout the
cytoplas* and nucleus of #asal keratinocytes
$. Cytoid #odies
%. 1**une deposits alon& the 0+ 4unction
'. 5ranular deposits alon& the #ase*ent
*e*#rane
(. A Ichicken"wireI pattern within the epider*is
A
$( Cutaneous warts in renal
transplant recipients show
increased e<pression of which
keratin.
1. K$
$. K(
%. KD
'. K1%
(. K1)
0
$) /he #est su#strate for
i**uno-uoresence in the
der*atolo&ic condition trans*itted
#y the #lack -y is:
1. Hat #ladder
$. Monkey esopha&us
%. 5uinea pi& esopha&us
'. Ar*adillo foot pads
(. ,hite *ouse tail
C
$A ,hich of the followin& options is
characteristic of inte&rins.
1. 0efects in the alpha") do*ain of inte&rin
result in epider*olysis #ullosa si*ple< with
*uscular dystrophy
$. Alpha")"Beta"' inte&rin is found at sites
where des*o&leins attach
%. +<pression is seen in all layers of the
epider*is
'. /he e<tracellular alpha) do*ain #inds
colla&en A
(. /hese proteins coordinate linka&e #etween
inter*ediate 6la*ents and e<tracellular *atri<
of the #ase*ent *e*#rane
+
$C ,hich of the followin& a*ino acids
are typically found in elastic 6#ers.
1. 0es*osine
$. 1soleucine
%. Proline
'. Fydro<yproline
(. 5lycine
A
$D /he cutaneous
i**uno-uorescence pattern in
patients with Senear"Bsher
syndro*e is:
1. 1ntercellular 1&5 and C%
$. 8inear 1&5 and C% alon& the #ase*ent
*e*#rane ;one
%. 1ntercellular 1&5 on &uinea pi& esopha&us
0
%
'. 1ntercellular 1&5 and C% and linear 1&5 and
C% alon& the #ase*ent *e*#rane ;one
(. 8inear 1&5 and C% alon& the #ase*ent
*e*#rane ;one and intercellular 1&5 on &uinea
pi& esopha&us
%! ,hich of the followin& state*ents
a#out &lo*us cells is correct.
1. /u*ors of &lo*us cells are *ost co**only
found on the ton&ue
$. Are of neural ori&in
%. Allow rapid shuntin& of #lood fro* the
arterioles to 3enules: #ypassin& capillaries
'. /u*ors co*posed of &lo*us cells are
asy*pto*atic
(. /u*ors co*posed of &lo*us cells are often
*ali&nant
C
%1 Keratinocytes are deri3ed fro*
which of the followin&:
1. +ndoder*
$. Mesoder*
%. +ctoder*
'. Eeural Crest
(. Bone *arrow precursors
C
%$ ,hich *echanoreceptor found in
hair #earin& areas sense deep
touch and 3i#ration.
1. Merkel cell
$. Meissner corpuscle
%. ?ater"Pacini corpuscle
'. Krase end"#ul#
(. 2ree ner3e endin&
C
%% ,hich of the followin& *edications
is concentrated in the eccrine
&lands.
1. Cyclophospha*ide
$. Cytara#ine
%. Cipro-o<acin
'. Cephale<in
(. All of the answers are correct
+
%' 0er*al dendrocytes: 1. Are responsi#le for i**ediate"type
hypersensiti3ity reactions.
$. Acti3ely synthesi;e and release 1&5.
%. Present anti&en to naJ3e / cells in the
ly*ph node.
'. Are the pri*ary cell found in a &lo*an&io*a.
(. Are the pri*ary cell found in an
an&iosarco*a.
C
%( ,hich ele*ent is necessary for
function of *atri<
*etalloproteinases.
1. 1ron
$. Eitro&en
%. Man&anese
'. Ma&nesiu*
(. Kinc
+
%) ,hich of the followin& diseases has
decreased or a#sent la*ellar
&ranules.
1. 2le&elGs
$. Psoriasis
%. 8a*ellar ichthyosis
'. +pider*olytic hyperkeratosis
(. Pe*phi&us 3ul&aris
A
%A ,hich of the followin& cells are
reLuired for wound healin&.
1. Eeutrophil
$. Macropha&e
%. +osinophil
'. 8an&erhans cell
(. 8y*phocyte
B
%C 5lo*us cells are: 1. Modi6ed 6#ro#lasts
$. Modi6ed skeletal *uscle cells
%. ?ascular s*ooth *uscle cells
'. Monocytes
(. Eeuronal cells
C
%D Apocrine &lands: 1. 0e*onstrate holocrine secretion
$. 0e*onstrate decapitation secretion
%. Are fully functional at #irth
B
'
'. Are diMusely distri#uted on the #ody
(. Are ther*ore&ulatory
'! /he &reatest density of *ast cells
is found in the:
1. Stratu* spinosu*
$. Stratu* #asale
%. Papillary der*is
'. Heticular der*is
(. Su#cutaneous fat
C
'1 ,hich si&nalin& *olecule *ediates
the transition of hair cyclin& fro*
telo&en to ana&en phase.
1. 2o<n1
$. 2&f(
%. Sonic hed&eho&
'. 0ihydotestosterone
(. (a"reductase
C
'$ ,hich one of the followin& is
responsi#le for *aintainin& a
#arrier to water loss in the stratu*
corneu*.
1. 1n3olucrin
$. 2ila&&rin
%. 8oricrin
'. /rans&luta*inase
(. 9dland #odies
+
'% /yrosinase is the en;y*e that
cataly;es the con3ersion of
tyrosine to 09PA and 09PA to
09PALuinone. /he en;y*e
contains which of the followin&
ions.
1. Kinc
$. Copper
%. Seleniu*
'. 1ron
(. Ma&nesiu*
B
'' /he *a4or protein co*ponent of
the corni6ed en3elope is:
1. +n3oplakin
$. 0es*oplakin
%. Plectin
'. 8oricrin
(. /rans&luta*inase
0
'( /he e*#ryonic perider* #eco*es
part of the
1. 3erni< caseosa
$. stratu* corneu*
%. stratu* #asale
'. der*is
(. hair follicle
A
') /he stren&th of a scar: 1. 1s (N at 1 week
$. 1s $!N at % weeks
%. 1s A!N at 1 year
'. All of these options are correct
(. Eone of these options are correct
0
'A Fo*ocystinuria has a#nor*al
crosslinkin& of colla&en #ecause of
a *utation in:
1. Cystathione synthase
$. /ype 1 colla&en E"peptidase &ene
%. 8ysyl hydro<ylase
'. /enascin O
(. 8ysyl o<idase
A
'C ,hich of the followin& protein
plays a *a4or role in wound
healin&.
1. Bncein
$. 2i#ronectin
%. Eido&en
'. +ntactin
(. Band") protein
B
'D 1n the epider*is: the cell *ost
responsi#le for anti&en detection
and processin& is the:
1. Keratinocytes
$. Merkel Cell
%. Melanocyte
'. 8an&erhans cell
(. C0'P / cell
0
(! Fow soon does epitheliali;ation
#e&in after a skin wound occurs.
1. Minutes
$. Fours
%. $ days
'. ' days
(. ) days
B
(1 0es*osine and isodes*osine are
typical a*ino acids found in:
1. Colla&en 6#ers
$. Anchorin& 6#ril
C
(
%. +lastic 6#ers
'. Feparan sulfate
(. Anchorin& plaLues
($ Hetinoids upre&ulate transcription
of which types of colla&en.
1. 1 and %
$. 1 and '
%. 1 and A
'. % and A
(. ' and A
C
(% Mutations in which of the followin&
&enes will produce red hair.
1. MC1"H
$. A&outi
%. Fairless
'. c"kit
(. /yrosinase
A
(' Keratinocytes ha3e #een shown to
secrete all of the followin&
cytokines e<cept:
1. 18"1
$. 18")
%. 18"C
'. /E2"alpha
(. 18"$
+
(( 0irect i**uno-uorescence
stainin& of intercellular spaces and
the #ase*ent *e*#rane ;one: in
co*#ination: is seen in:
1. Paraneoplastic pe*phi&us
$. Anti"epili&rin pe*phi&oid
%. Pe*phi&us 3e&etans
'. Pe*phi&us foliaceous
(. 1&A pe*phi&us
A
() /he des*oso*al connections of
the epider*is are dependent on
which of the followin& ions.
1. 1ron
$. Kinc
%. Seleniu*
'. Calciu*
(. Sodiu*
0
(A ,hich of the followin& is the *ost
co**on &enetic alteration seen in
*ucosal *elano*as.
1. 5EAQ
$. Cyclin 0ependant Kinase ')
%. BHA2
'. K1/
(. F0M$
0
(C People with darker skin show: 1. S*aller: *ore concentrated *elanoso*es
$. A *ore rapid de&radation of *elanoso*es
%. A lessened production of *elanoso*es
within *elanocytes
'. A hi&her de&ree of dispersion of
*elanoso*es in keratinocytes
(. A &roupin& of *elanoso*es with a low
de&ree of *elani;ation
0
(D A salt split skin 012 is perfor*ed on
a #iopsy taken ad4acent to the skin
lesions shown. ,here would you
e<pect stainin& to #e seen.
1. +pider*al side
$. 0er*al side
%. +pider*al and 0er*al sides eLually
'. 1n the la*ina densa
(. 1n the anchorin& plaLues
A
)! ,hich epony* descri#es 3esti&ial
lines of pi&*entary de*arcation.
1. 2uchter lines
$. ,allaceGs lines
%. 8an&erGs lines
'. 8ines of Blaschko
(. 0er*ato*e
A
)1 +ach of the followin& is true a#out
the #ase*ent *e*#rane ;one
e<cept:
1. Anchorin& 6la*ents attach the #asal cell
*e*#rane to the la*in lucida
$. Can #e 3isuali;ed on li&ht *icroscopy with
PAS stainin&
%. 8a*ina densa is co*posed of type 1?
colla&en
'. Contains la*inin 1 and la*inin (
(. Anchorin& 6#rils are co*posed of type ?11
colla&en
A
)
)$ 0urin& hair follicle de3elop*ent:
the ,E/ si&nalin& pathway is one
of the earliest *olecular pathways
in3ol3ed in hair follicle initiation.
,hat is the downstrea* *ediator
of ,E/ si&nalin&.
1. S*oothened
$. Beta"catenin
%. Keratin 1)
'. p(%
(. F8A"B$A
B
)% /ype ?11 colla&en in found in
anchorin& 6#rils and also in:
1. 2etal skin
$. Bone
%. A*nion
'. Aorta
(. Blood 3essels
C
)' 1tch is *ost co**only trans*itted
#y:
1. C"poly*odal nociceptor class ner3es
$. A"delta class ner3es
%. A"#eta class ner3es
'. Parasy*pathetic post&an&lionic 6#ers
(. A"#eta and A"delta 6#ers
A
)( ,hat co*ponent is the *a4or
#arrier in the stratu* corneu*.
1. Se#u*
$. SLualene
%. Colla&en
'. Cera*ide
(. /ri&lycerides
0
)) Sneddon ,ilkinson disease is
caused #y a defect in what
anti&en.
1. 0es*ocollin 1
$. 0es*o&lein 1
%. 0es*o&elin %
'. BPA&1
(. BPA&$
A
)A ,hich of the followin& state*ents
a#out elastic 6#ers is true.
1. +lastic 6#ers for* %(N of the dry wei&ht of
the skin
$. +lastic 6#ers are D!N elastin wrapped in
6#rillin
%. Colla&en 1 is *utated in Marfan syndro*e
'. 9<ytalan 6#ers run parallel within the
super6cial papillary der*is
(. +launin 6#ers run perpendicular in thin
#ands within the reticular der*is.
B
)C ,here are &lo*us cells deri3ed
fro*.
1. Mesenchy*e
$. Bone *arrow
%. SusLuet"Foyer canal
'. Skeletal *uscle
(. 0er*is
C
)D ,hich of the followin& cytokines
are secreted fro* keratinocytes.
1. 18"$
$. 18"%
%. 18"1A
'. 18"$$
(. 18"$%
+
A! 0es*o&lein 1 is the anti&en in
which of the followin& autoi**une
diseases of the skin:
1. Pe*phi&us foliaceus
$. Bullous i*peti&o
%. 0er*atitis herpetifor*is
'. Bullous pe*phi&oid
(. Pe*phi&oid &estationis
A
A1 ,hich cytokeratin would you
e<pect to #e preferentially
e<pressed in the keratinocytes of a
psoriatic plaLue:
1. K1
$. K(
%. K1$
'. K1(
(. K1)
+
A$ +launin 6#ers: 1. Hun parallel in #ands within the super6cial
papillary der*is
$. Hun perpendicular fro* the der*o"epider*al
4unction within the super6cial papillary der*is
%. Hun parallel in #ands within the reticular
C
A
der*is
'. Hun perpendicular in #ands within the deep
der*is
(. Hun perpendicular in #ands within the
reticular der*is
A% He&ardin& der*al"epider*al
4unction: which of the followin&
state*ents is true:
1. /here are no anchorin& 6la*ents in la*ina
lucida
$. 8a*ina 6#roreticularis lies a#o3e la*ina
densa
%. 8a*ina 6#roreticularis co*prises of
anchorin& 6#rils and the elastic *icro6#rils
'. Blood 3essels cross the der*al"epider*al
4unction to reach the epider*is
(. 8a*ina lucida is an electron"dense layer
C
A' ,hich of the followin& en;y*es
does not reLuire copper for
functionin&.
1. 8ysyl o<idase
$. A/PAa
%. /yrosinase
'. Cystathione #eta"synthase
(. 2errochelatase
+
A( ,hat structure delineates the
anato*ic re&ion #etween the nail
#ed and the distal &roo3e: where
the nail plate detaches of the distal
portion of the di&it.
1. Eail *atri<
$. Pro<i*al nail fold
%. 8unula
'. +ponychiu*
(. Fyponychiu*
+
A) ,hich keratins are e<pressed in
the stratu* &er*inati3u* and are
present #ut not *ade de no3o in
the stratu* spinosu*.
1. K': 1%
$. K1:1!
%. K$e: 1!
'. K%:1$
(. K(:1'
+
AA ,hich of the followin& der*al cells
always e<press C011c and C0).
1. Mononuclear pha&ocytic cells
$. 2i#ro#lasts
%. Mast cells
'. +rythrocytes
(. 5lo*us cells
A
AC ,hich of the followin& state*ents
a#out darkly pi&*ented races
3ersus li&hter pi&*ented races is
correct.
1. /he nu*#er of *elanoso*es in *elanocytes
are the sa*e
$. /he indi3idual *elanoso*es ha3e the sa*e
de&ree of *elani;ation
%. /he *elanoso*es are eLual in si;e
*elanoso*es
'. /here are eLual nu*#ers of *elanocytes
(. /here is a faster rate of *elanoso*e
de&radation
0
AD ,hich of the followin& do*ains is
tar&eted #y the autoanti#odies in
#ullous pe*phi&oid.
1. EC1)A of BP1C!
$. 8a*inin (
%. Plectin
'. alpha") inte&rin
(. EC1)A of BP$%!
A
C! Acid keratins are e<pressed on
which of the followin&
chro*oso*es.
1. 1$
$. 1A
%. D
'. 1)
(. %
B
C1 ,hich of the followin& cytokines is
secreted #y adipocytes.
1. 18"$
$. 1l"'
%. 18")
'. 18"1!
(. 18"1$
C
C$ /issue contraction #e&ins: 1. At %rd day of wound healin&
$. 0urin& the $nd week of wound healin&
B
C
%. After the 6rst *onth of wound healin&
'. After the %rd *onth of wound healin&
(. After the Dth *onth of wound healin&
C% /he hair follicle is the site of
production or con3ersion of which
of the followin& hor*ones.
1. All the options are correct
$. dihydrotestosterone =0F/>
%. prolactin
'. adrenocorticotropin hor*one =AC/F>
(. alpha"*elanocyte sti*ulatin& hor*one
=MSF>
A
C' ,hat is the *a4or function of
urocanic acid.
1. Bacteriocidal acid produced #y stratu*
corneu*
$. Pri*arily a B?B 6lter
%. Pri*arily a B?A 6lter
'. Felps de&rade free fatty acids
(. Aids in protectin& the skin fro*
der*atophytes
C
C( A speci6c *arker of Merkel cells is: 1. Cytokeratin 1!
$. Cytokeratin 1(
%. Cytokeratin $!
'. 8oricrin
(. +n3oplakin
C
C) ,hich keratins are upre&ulated in
hyperproliferati3e disease such as
psoriasis.
1. Keratins 1 and 1!
$. Keratins $e and 1!
%. Keratins ( and 1'
'. Keratins ) and 1)
(. Keratins C and 1C
0
CA A AC year"old *an is dia&nosed
with cicatricial pe*phi&oid. ,hich
of the followin& anti&ens #ein&
i*plicated in his disease should
tri&&er a work"up for *ali&nancy.
1. BPA&$
$. 8a*inin (
%. 8a*inin )
'. Beta"' inte&rin
(. /ype ?11 colla&en
B
CC /he *ain per*ea#ility #arrier in
the la*ina densa is:
1. heparan sulfate proteo&lycan
$. colla&en 1?
%. la*inin (
'. nido&en
(. alpha")"#eta"' inte&rin
A
CD Mo3in& fro* internally to
e<ternally choose the correct
description of the hair follicle:
1. 1nner root sheath cuticle " Fu<leyGs layer "
FenleGs layer " *edulla " corte< " hair shaft
cuticle
$. Fair shaft cuticle " corte< " *edulla " FenleGs
layer " Fu<leyGs layer Q inner root sheath cuticle
%. FenleGs layer " Fu<leyGs layer " inner root
sheath cuticle " hair shaft cuticle " corte< "
*edulla
'. Medulla Q corte< Q hair shaft cuticle Q inner
root sheath cuticle Q Fu<leyGs layer Q FenleGs
layer
(. 1nner root sheath cuticle Q outer root sheath
cuticle Q hair shaft cuticle Q corte< Q Fu<leyGs
layer Q FenleGs layer
0
D! Platelets release which of the
followin& factors to pro*ote new
tissue &rowth.
1. Eeutrophil che*otactic factor
$. 18"1
%. A0P
'. /52"alpha
(. 252
0
D1 ,hich co*ponent of hair is
positi3e for citrulline.
1. 9uter root sheath
$. 1nner root sheath
%. Corte<
'. 5lassy 3itreous layer
(. Medulla
B
D
D$ ,hat percenta&e of the dry wei&ht
of skin in elastin.
1. $
$. '
%. )
'. C
(. 1!
B
D% Apocrine &lands: 1. Are coiled &lands
$. Fa3e a two se&*ent ducts that e*pties onto
the skin
%. Are present e3erywhere on the skin e<cept
on the pal*s and soles
'. 2unction fro* #irth
(. Secretions are initially odorless
+
D' All *ononuclear pha&ocytic cells in
the der*is e<press:
1. C0%
$. C0)
%. C0%'
'. C0)C
(. C0$!
B
D( /he epider*is is co*prised of what
type of cells.
1. Keratinocytes: Melanocytes: Merkel cells:
8an&erhan cells
$. Keratinocytes: +ndothelial cells: Merkel cells:
8an&erhan cells
%. Keratinocytes: Melanocytes: Eeutrophils:
8an&erhan cells
'. Keratinocytes: Melanocytes: Merkel cells:
5o#let cells
(. Keratinocytes: +ndothelial cells: Merkel cells:
5o#let
A
D) 0efects in what kind of structural
protein lead to pyloric atresia
associated with 4unctional
epider*olysis #ullosa:
1. Colla&en
$. +lastin
%. 8oricrin
'. 1nte&rin
(. Plectin
0
DA ,hat is the *ost i*portant cell for
wound healin&.
1. 2i#ro#lasts
$. Eeutrophils
%. Macropha&es
'. 8y*phocytes
(. Mast cells
C
DC All of the followin& are true
re&ardin& the for*ation of hair
e<cept:
1. /he inner root sheath keratini;es #y *eans
of trichohyalin &ranules
$. FenleJs layer is outside of Fu<leyJs layer
%. /he outer root sheath is a downward
e<tension of the epider*is
'. Fu<leyJs layer contains *elanin
(. /he hair *atri< #eco*es the hair and the
inner root sheath
0
DD At what esti*ated &estational a&e
are all layers of the keratini;ed
epider*is identi6a#le.
1. C weeks
$. 1$ weeks
%. 1) weeks
'. $! weeks
(. $' weeks
+
1!! ,hich cadherin is responsi#le for
adhesion of 8an&erhan cells to the
epider*is.
1. +"cadherin
$. P"cadherin
%. E"cadherin
'. 0es*o&lein
(. 0es*ocollin
A
1!1 Fo*ocystinuria is an autoso*al
recessi3e condition with 6ndin&s
includin& a *arfanoid ha#itus:
downward dislocation of the lens:
cardio3ascular disease and *ental
1. A#nor*al crosslinkin& of colla&en
$. A#nor*al de3elop*ent of elastin 6#ers
%. Melanocyte death
'. Pi&*entation of cartila&e
(. Black urine
A
1!
retardation. 1t is caused #y a
*utation in cystathionine #eta"
synthetase. ,hat does this
*utation in cystathionine #eta"
synthetase cause other than an
accu*ulation of ho*ocystine.
1!$ Fair follicle de3elop*ent in the
hu*an e*#ryo #e&ins durin&:
1. 1st tri*ester
$. $nd tri*ester
%. %rd tri*ester
'. At the #lastocoele sta&e
(. ,ithin $ weeks of fertii;ation
A
1!% Bpon presentation of an anti&en in
the skin surface: a hapten for*s.
/he 6rst cell to take up the hapten
is:
1. B cells
$. 8an&erhans cells
%. keratinocytes
'. / cells
(. Mast cell
B
1!' ,hich of the followin& keratins
would *ost likely #e e<pressed in
the nail #ed.
1. K)a1)
$. K)#1A
%. K1D
'. K$e1!
(. K'1%
B
1!( Keratohyalin &ranules contain: 1. 0es*oplakin
$. +n3oplakin and Keratin )
%. Pro6la&&rin and loricrin
'. Eu*erous 5ol&i apparati
(. 1n3olucrin
C
1!) +lastic 6#ers contain the speci6c
a*ino acids:
1. 8ysine and proline
$. 8eucine and isoleucine
%. Alanine and phenylalanine
'. 0es*osine and isodes*osine
(. 5lycine and proline
0
1!A ,hich of the followin&
polypeptides is found in the la*ina
lucida.
1. plako&lo#in
$. des*oplakin
%. keratocal*in
'. de*oyokin
(. la*inin (
+
1!C ,hich of the followin& is not a
speciali;ed type of se#aceous
&land.
1. MollGs &land
$. Mei#o*ian &land
%. 5land of Keis
'. Mont&o*eryGs tu#ercle
(. 2ordyce spot
A
1!D /he anti#ody tar&et in ocular
cicatricial pe*phi&oid is also
*utated in:
1. 7unctional epider*olysis #ullosa: Ferlit; type
$. Hecessi3e dystrophic epider*olysis #ullosa
%. 7unctional epider*olysis #ullosa with
*yotonic dystrophy
'. 0o*inant dystrophic epider*olysis #ullosa
(. 7unctional epider*olysis #ullosa with pyloric
atresia
+
11! 0urin& e*#ryo&enesis: perider*
cells of the fetus contain which of
the followin& su#stances.
1. Cera*ide
$. 5lyco&en
%. 2ree fatty acids
'. Porphyrins
(. Se#u*
B
111 Anchorin& 6#rils are pri*arily
co*posed of:
1. /ype 1 colla&en
$. /ype 111 colla&en
%. /ype 1? colla&en
'. /ype ?11 colla&en
(. /ype 11 colla&en
0
11$ ,hich of the followin& is true a#out
*elanoso*es.
1. Spheroid *elanoso*es ha3e concentric
la*ellae
+
11
$. Spheroid *elanoso*es synthesi;e #rown"
#lack eu*elanin
%. +lliptical *elanoso*es ha3e *icro3esicular
structure
'. +lliptical *elanoso*es synthesi;e yellow or
red pheo*elanin.
(. /he *elanoso*es are positioned after the
5ol&i apparatus in the secretory pathway.
11% At any one ti*e: the appro<i*ate
proportion of hair follicles in
ana&en is:
1. '!N
$. )!N
%. C(N
'. D(N
(. 1(N
C
11' /he 6rst pri*ordial hair follicles
for* on the eye#rows: upper lip
and chin at which &estational a&e.
1. A weeks
$. D weeks
%. 1$ weeks
'. 1) weeks
(. $! weeks
B
11( Anchorin& 6la*ents ori&inate at
the he*ides*oso*es and insert
into the:
1. 0es*oso*e
$. Su# #asal dense plate
%. 8a*ina lucida
'. BPA5 1C!
(. 8a*ina densa
+
11) 9dland #odies: 1. Contain keratins
$. Are found intercellularly in the #asal cell
layer
%. Are e<clusi3ely intracellular
'. Crosslink with keratins ( and 1'
(. Are secretory &ranules with features of
lysoso*es
+
11A /elo&en eRu3iu*: 1. 1n3ol3es a diMuse alopecia aMectin& *ore
than (!N of the scalp
$. 9ften results fro* anti*eta#olites used
durin& cancer che*otherapy
%. 1s an in-a**atory alopecia de3oid of
scarrin&
'. 1s a patchy alopecia aMectin& less than (!N
of the scalp
(. Hesults fro* sudden illness or sur&ery
+
11C ,hat is the *a4or co*ponent of
the anchorin& 6#ril.
1. /ype 1 Colla&en
$. /ype 111 Colla&en
%. /ype 1? Colla&en
'. /ype ?11 Colla&en
(. 8a*inin (
0
11D Ana&en eRu3iu* is #est descri#ed
as:
1. An a#ru#t transition fro* ana&en to cata&en
in rapidly di3idin& hair *atri< cells
$. A cessation of *itotic acti3ity in rapidly
di3idin& hair *atri< cells
%. An a#rupt transition of telo&en to ana&en in
restin& hair *atri< cells
'. A cessation of *itotic acti3ity in restin& hair
*atri< cells
(. A scarrin& alopecia aMectin& only ana&en
sta&e follicles
B
1$! ,hat is the a3era&e duration of the
telo&en cycle in ter*inal scalp
hair.
1. $") years
$. $"% weeks
%. % *onths
'. ) *onths
(. D *onths
C
1$1 He&ardin& se#aceous &lands: 1. /hese &lands are present at #irth at their 0
1$
adult si;e
$. Si;e of the &land is proportional to the si;e of
the associated hair follicle
%. Are always associated with a hair follicle
'. Are found e3erywhere on the skin e<cept
pal*s and soles
(. Are unilo#ular &lands
1$$ ,hich hor*one is ho*olo&ous to
alpha"MSF =*elanocyte
sti*ulatin& hor*one>.
1. 1nsulin
$. Fu*an &rowth factor
%. Prolactin
'. /hyroid sti*ulatin& hor*one
(. Adrenocorticotropic hor*one
+
1$% Ana&en eRu3iu* is 1. Harely seen followin& ad*inistration of
cancer che*otherapeutic a&ents
$. Sti*ulus induces the a#rupt cessation of
*iotic acti3ity in the rapidly di3idin& hair *atri<
cells
%. 9ccurs within $' to 'C hours of e<posure
'. +ntirely inre3ersi#le
(. Patients #ein& treated with nitrosurea a&ents
are usually spared
B
1$' +*#ryolo&ically: epider*al
strati6cation occurs at
appro<i*ately what esti*ated
&estational a&e.
1. ' weeks
$. C weeks
%. 1$ weeks
'. 1) weeks
(. $! weeks
B
1$( He&ardin& the stratu*
&er*inati3u* =#asale>:
1. 1nter*ediate 6la*ents in #asal cells insert
into only he*ides*oso*es
$. Keratins 1 and 1! are e<pressed
%. Eot all #asal cells ha3e the potential to
di3ide
'. Micro6la*ents assist in downward
*o3e*ent of cells
(. Plectins re&ulate adhesion and initiation of
diMerentiation.
C
1$) He&ardin& the stratu* spinosu*:
which of the followin& is correct.
1. Eo keratin 11! is present
$. Eew synthesis of K(1' occurs in this layer
%. /he IspinesI seen on patholo&y are due to
des*oso*al connections #etween keratinocytes
'. /his layer contains *elanocytes
(. /his layer contains the corni6ed cell
*e*#rane
C
1$A +lastic 6#ers are present in the
der*is and are responsi#le for
pro3idin& tissue resiliency. /hey
are co*prised of elastin as well as
*icro6#rillar proteins includin&:
1. 2i#rillins and 6#ulins
$. Fyaluronic acid
%. Colla&en 11
'. 8a*inin ( and BPA5$
(. 0es*oplakin and plako&lo#in
A
1$C ,hat is the location of the
un#ound corticosteroid receptor.
1. Cytoplas*
$. Eucleus
%. Mitochondria
'. Plas*a *e*#rane
(. &ol&i apparatus
A
1$D 5ranulation tissue pri*arily
contains:
1. Colla&en 1
$. Colla&en 111
%. Colla&en 1?
'. 2i#rin
(. Colla&en ?11
B
1%! Se#aceous &lands for* a lipid"rich
su#stance called se#u* and are
usually associated with a hair
1. ?acuolar e<ocytosis
$. Passi3e diMusion
%. 0ecapitation secretion
+
1%
follicle. /hey secrete se#u* #y
what *echanis*.
'. Autocrine secretion
(. Folocrine secretion
1%1 1 *elanocyte has contact with: 1. ) keratinocytes
$. 1$ keratinocytes
%. 1C keratinocytes
'. %! keratinocytes
(. %) keratinocytes
+
1%$ All of the followin& pertain to
9dland #odies +OC+P/:
1. Contain sLualene
$. Are found intracellularly in upper le3el
keratinocytes
%. 0ischar&e their contents into the
e<tracellular space at the 4unction of the &ranular
and corni6ed layers
'. +sta#lish a #arrier to water loss
(. Mediate stratu* corneu* adhesion in
con4unction with 6la&&rin.
A
1%% ,hich of the followin& is a *e*#er
of the ar*adillo fa*ily of linkin&
proteins.
1. +"cadherin
$. Periplakin
%. +n3oplakin
'. 0es*ocollin
(. Plako&lo#in
+
1%' Eu*erous neuro*ediators are
in3ol3ed in cutaneous neuro#iolo&y
and *any play a role in the
de3elop*ent of in-a**ation in
the skin. 9ne such *ediator can #e
induced #y application of capsaicin
to the skin. ,hich of the followin&
is the correct neuro*ediator.
1. Eoradernaline
$. Su#stance P
%. Eeurokinin A
'. Acetylcholine
(. Pro"opio*elanocortin
B
1%( /ype 1 colla&en is the *ost
pre3alent colla&en in skin:
accountin& for C!N or *ore of the
total colla&en in the adult der*is.
/he ne<t *ost predo*inant
colla&en in adult hu*an der*is is:
1. /ype 11 colla&en
$. /ype 111 colla&en
%. /ype 1? colla&en
'. /ype ?11 colla&en
(. /ype O?11 colla&en
B
1%) Melanocytes are deri3ed fro*: 1. Bone *arrow
$. Eeural crest
%. Mesoder*al precursors
'. +ndoder*al precursors
(. Solk sac deri3ed
B
1%A ,hich of the followin& *ake up the
*a4or protein of the corni6ed cell
en3elope.
1. 8oricrin
$. 1n3olucrin
%. +n3oplakin
'. 2ila&&rin
(. 8a*inin ?
A
1%C Mast cells are deri3ed fro* #one
*arrow QQQQP cells.
1. C0%
$. C0)
%. C0$!
'. C0%'
(. C0)C
0
1%D ,hich of the followin&
a#nor*alities would #e present in
a patient with FarleLuin
ichthyosis.
1. la*ellar &ranules are unifor*ly a#sent
$. keratohyaline &ranules are nor*al in all
types of harleLuin fetus
%. de*oyokin *utation
'. #and ) protein is a#sent
(. plako&lo#in is a#nor*al
A
1'! ,hich cell type is reLuired for
wound healin&.
1. Macropha&e
$. 8y*phocyte
%. Mast cell
'. 0er*al dendrocyte
A
1'
(. Eeutrophil
1'1 Acid keratins =K1!"$!> are
e<pressed on which of the
followin& chro*oso*es.
1. 1A
$. 1C
%. 1D
'. 1!
(. 1$
A
1'$ Apocrine chro*hidrosis results
fro* which of the followin&
contents of apocrine sweat.
1. 8ipofuschin
$. SLualene
%. Cholesterol
'. 2atty acids
(. A**onia
A
1'% Mei#o*ian &lands are: 1. +ccrine &lands locali;ed to the 3er*illion
#order of the lips
$. Se#aceous &lands found on the areola of the
#reast
%. Se#aceous &lands found on the eyelids
'. Apocrine &lands found in the ano&enital
re&ions
(. Apocrine &lands found on the eylelids
C
1'' /he triple heli< of the colla&en
*olecule is lar&ely *aintained due
to its a*ino acid co*position. /he
polypeptide chains of colla&en are
repeatin& triplets of 5lycine"O"S.
/he O and S positions can #e
occupied #y *ultiple a*ino acids:
#ut are *ost often:
1. Alanine and aspara&ine
$. /yrosine and threonine
%. Fistidine and ornithine
'. 8eucine and isoleucine
(. Proline and hydro<yproline
+
1'( Fu*an se#u* is distin&uished
fro* lipids of internal or&ans #y
the presence of:
1. Cholestrol
$. Cholestrol esters
%. SLualene
'. ,a< esters
(. 5lycerides
0
1') /he 6rst cell type to *i&rate into a
new wound in &reat nu*#ers is
the:
1. Eeutrophil
$. Monocyte
%. Macropha&e
'. 8y*phocyte
(. Mast cell
A
1'A 0ystrophic epider*olysis #ullosa
results fro* *utations in:
1. Colla&en type 1
$. Colla&en type 11
%. Colla&en type 111
'. Colla&en type ?
(. Colla&en type ?11
+
1'C ,hich of the followin& state*ents
a#out 8a*inins is correct.
1. 8a*inins span fro* the plas*a *e*#rane
of #asal keratinocytes to the la*ina lucida
$. 8a*inins pro3ide little structural support in
the #ase*ent *e*#rane
%. 8a*inins pro3ide si&nalin& *olecules that
interact with other proteins to trans*it
*orpho&enetic infor*ation to the cellGs interior
'. 8a*inin ( is also called plectin
(. 8a*inin ( is the only la*inin found in the
#ase*ent *e*#rane
C
1'D ,hich of the followin& skin
conditions in3ol3es elastin.
1. Hoth*und"/ho*pson
$. +pider*olytic Fyperkeratosis
%. Pseudo<antho*a elasticu*
'. Pro&eria
(. Classic type +hlers"0anlos syndro*e
C
1(! ,hich of the followin& ele*ents is
necessary for *elanin production.
1. Copper
$. Seleniu*
%. 1ron
A
1(
'. Kinc
(. Calciu*
1(1 Keratinocytes in the #asal layer of
the epider*is attach to the
#ase*ent *e*#rane ;one at
he*ides*oso*es 3ia what
inter*ediate 6la*ent *olecules.
1. Keratins 1 and 1!
$. Keratins ( and 1'
%. 0es*o&leins 1 and %
'. 0es*oplakin and 0es*o&lo#in
(. BPA51 and BPA5$
B
1($ ,hich of the followin& stains would
you e<pect to #e positi3e in a
nor*al eccrine unit.
1. S"1!!
$. Prussian #lue
%. 5ie*sa
'. ?erhoeM 3on 5ieson
(. Steiner
A
1(% ,hich of the followin& state*ents
a#out plectin is correct.
1. 8inks 6lla&rin to the plas*a *e*#rane
$. Crosslinks proteins in adherens 4unction
%. Mutations result in 4unctional epider*olysis
#ullosa with pyloric atresia
'. Plectin is a *e*#er of the plakin fa*ily
(. Plectin is a constituent protein of the
des*oso*al plaLue
0
1(' Aprocrine &lands are adne<al
&lands that are Luiescent until
pu#erty. 9nce acti3e: they secrete
their contents #y what
*echanis*.
1. ?acuolar e<ocytosis
$. Passi3e diMusion
%. 0ecapitation secretion
'. Autocrine secretion
(. Folocrine secretion
C
1(( ,hat is the *ost a#undant
colla&en found on fetal skin.
1. /ype 1 Colla&en
$. /ype 11 Colla&en
%. /ype 111 Colla&en
'. /ype 1? Colla&en
(. /ype ?11 Colla&en
C
1() 9nce a keratinocyte lea3es the
#asal cell layer: the nor*al transit
ti*e to stratu* corneu* is at
least:
1. A days
$. 1' days
%. $1 days
'. $C days
(. %( days
B
1(A Se#aceous &lands are located in
each of the followin& locations
e<cept:
1. Eipple
$. 8a#ia *inora
%. Pal*s
'. +yelids
(. Buccal *ucosa
C
1(C 1n which of the followin& locations
would you #e least likely to identify
*elanocytes.
1. Stria 3ascularis of the ear
$. 1ris
%. 8epto*enin&es
'. Hetina
(. Pericardiu*
+
1(D ,hich of the followin& is true
re&ardin& BPA&1.
1. 1t is patho&enic in cicatricial pe*phi&oid
$. 1t is a *e*#er of the plakin fa*ily
%. 1t is patho&enic in pe*phi&oid &estationis
'. 1t is not patho&enic in paraneoplastic
pe*phi&us
(. 1t coprecipitates with plako&lo#in
B
1)! Sur&ery: Parturition: 2e3er:
Kwashiokor and Fyper3ita*inosis
A are all causes of:
1. /elo&en eRu3iu*
$. Ana&en eRu3iu*
%. Alopecia areata
'. Andro&enetic alopecia
(. Both telo&en and ana&en eRu3iu*
A
1)1 ,hich of the followin& &lands is not
under neural control.
1. Se#aceous &lands
$. Apocrine &lands
%. +ccrine &lands
'. Sali3ary &lands
(. Ceru*inous &lands
A
1)
1)$ /he for*ation of &ranulation tissue
depends on the presence of:
1. Eeutrophils
$. 2i#ronectin
%. Colla&en type 1
'. Platelets
(. Colla&en type 1?
B
1)% /he function of
&lycosa*ino&lycansproteo&lycans
in the der*is is:
1. He&ulate water"#indin& capacity
$. 1nteract with der*al dendrocytes
%. 2acilitate C98?11 #indin& to the anchorin&
plaLues
'. 2acilitate *ast cell de&ranulation
(. He&ulate ly*phocyte traTckin&
A
1)' /he *ain colla&en co*ponent of
the #ase*ent *e*#rane is:
1. Colla&en 1?
$. Colla&en 111
%. Colla&en 1
'. /enascin"O
(. Colla&en ?11
A
1)( ,hat is the si&ni6cance of the
critical line of Au#er.
1. 1t is the location of the insertion of the
erector pili *uscle
$. the #ulk of the *itotic acti3ity in the hair
occurs a#o3e this line
%. the inner root sheath is for*ed a#o3e this
line
'. 1t is the widest dia*eter of the hair #ul#
(. 1t is where keratini;ation 6rst occurs in the
hair
0
1)) Se#aceous &lands secrete se#u*
3ia:
1. Folocrine *echanis*
$. +<ocrine *echanis*
%. +ndocrine *echanis*
'. +<ostosis
(. Mecrocrine *echanis*
A
1)A Se#aceous &lands: 1. Hespond to che*ical sti*uli such as
hor*ones
$. Hespond to choliner&ic neural acti3ity:
e<clusi3ely
%. Hespond to adrener&ic neural acti3ity:
e<clusi3ely
'. Hespond to #oth adrener&ic and choliner&ic
sti*uli
(. Hespond to the local release of cytokines
fro* in-a**atory cells
A
1)C /he classical types of +hlers"
0anlos Syndro*es =/ype 1 and $>
lead to 3aryin& de&rees of
hypere<tensi#le skin: easy
#ruisin&: wide: atrophic scars: and
hyper*o#ile 4oints. /he underlyin&
defect in this disorder is a *utation
in:
1. +lastin
$. 2i#rillin 1
%. ABCC)
'. Colla&en ?
(. Cystathionine #eta"synthase
0
1)D Choose the correct answer
re&ardin& *elanin and skin color:
1. 1n #lack and #rown skin the *elanoso*es
are s*aller in dia*eter and len&th
$. 2acultati3e skin color is the a*ount of
cutaneous *elanin pi&*ent &enerated accordin&
to cellular &enetics
%. 1n white skin the *elanoso*es for* &roups
within the secondary lysoso*es
'. +u*elanin produces a yellow chro*ophore
(. /he nu*#er of *elanocytes increases with
one e<posure to B?A3isi#le li&ht
C
1A! ,hich of the followin& *arkers are
speci6c and relia#le for Merkel
1. C0$!
$. FMB"'(
+
1A
cells. %. C0%'
'. C0%
(. CK$!
1A1 Mei#o*ian &lands are: 1. Modi6ed se#aceous &lands
$. 2ound e3erywhere e<cept on the pal*s and
soles
%. Se#aceous lo#ules that feed into a
lactiferous duct
'. Modi6ed ceru*inous &lands
(. Modi6ed apocrine &lands
A
1A$ 5lo*us cells are pri*arily found: 1. on handsfeet
$. on the trunk
%. on the lateral thi&hs
'. on the &enital skin
(. on the face
A
1A% +ccrine &lands are found in all the
followin& areas of the #ody e<cept:
1. A<illae
$. Pal*s
%. 8a#ia *inora
'. Scalp
(. Cutaneous lip
C
1A' Merkel cells are *echanoreceptors
found in areas of hi&h"tactile
sensiti3ity. /his
i**unohistoche*ical *arker is
restricted to Merkel cells in the skin
and is thus a relia#le *arker for
these cells:
1. Keratin A
$. Keratin $!
%. S"1!!
'. 2actor O111a
(. 8S?+"1
B
1A( 8+M0% is *utated in which of the
followin& syndro*es.
1. Buschke 9llendorf
$. Al#ri&ht Fereditary 9steodystrophy
%. 5olt;
'. McCune"Al#ri&ht
(. Menkes
A
1A) BP$%! is a *e*#er of of which of
the followin& fa*ilies.
1. Plakin
$. 1nte&rin
%. 8a*inin
'. Colla&en
(. +lastin
A
$.1**unoder*atolo&y
# Question Answers Corre
ct
Answ
er
1 /he hu*an leukocyte anti&en that has the
closet association with psoriasis is:
1. F8A"B(1
$. F8A"0Q%
%. F8A"B$A
'. F8A"Cw)
(. F8A"0H1
0
$ Ferpes si*ple< 3irus"related erythe*a
*ultifor*e has #een associated with an
increased freLuency of:
1. F8A"BA
$. F8A"BC
%. F8A"B1%
'. F8A"B1(
(. F8A"B$A
0
% /he *ost co**on autoi**une disorder in
patients with chronic hepatitis C infection is:
1. Autoi**une thyroiditis
$. 1diopathic thro*#ocytopenic
purpura
%. Hheu*atoid arthritis
'. S4J&renJs syndro*e
(. Syste*ic lupus erythe*atosus
A
' /he #est screen for classical pathway
co*ple*ent de6ciency or dysfunction is:
1. C0'C0C ratio
$. CF(!
%. C$ esterase le3els
'. /otal C' le3els
B
1C
(. Seru* electophoresis
( ,hich 3irus is *ost closely associated with
KaposiUVWs sarco*a in F1?"infected patients.
1. Fu*an herpes 3irus $
$. Cyto*e&alo3irus
%. Fu*an herpes 3irus )
'. Fu*an herpes 3irus C
(. +pstein"Barr 3irus
0
) ,hich of the followin& diseases occur with an
increased freLuency in persons de6cient in C$.
1. Psoriasis
$. 0er*atitis Ferpetifor*is
%. Andro&enetic Alopecia
'. 08+
(. 8einerGs disease
0
A ,hich /"cell su#set is co**only found in
SJ;ary syndro*e.
1. C0'PC0AP
$. C0CPC0A"
%. C0'"C0AP
'. C0'PC0A"
(. C0CPC0AP
0
C ,hich of the followin& is not true a#out the
eMects of ultra3iolet radiation on the i**une
syste*.
1. B? radiation causes an increase in
nu*#er of 8an&erhans cells in the
epider*is
$. B? radiation causes nuclear 0EA
da*a&e
%. +Mects can #e de*onstrated #y the
e<a*ple of reacti3ation of latent herpes
si*ple< infection after sun e<posure
'. B? radiation acts to suppress the
i**une syste* #oth locally and
syste*atically
(. +Mects can #e de*onstrated #y the
a#ility of an anti&en to induce an aller&ic
hypersensiti3ity reaction when applied to
skin which has #een e<posed to low
doses of B? radiation
A
D Ma4or histoco*pati#ility co*ple< =MFC> Class 1
*olecules:
1. Are induci#le on keratinocytes
$. Co*ple<ed with anti&en tri&&er
cytoto<ic / cells
%. Are reco&ni;ed #y receptors on
C0'P / cells
'. Bear peptides deri3ed fro*
patho&ens taken up into 3esicles
(. All of the a#o3e
B
1! ,hich cytokine is the *ain *acropha&e"
acti3atin& cytokine.
1. /E2
$. 12E"&a**a
%. 18"'
'. 18"1!
(. ly*photo<in
B
11 1**unocyto*as are: 1. 8ow &rade B"cell ly*pho*as
$. A&&ressi3e B"cell ly*pho*as
%. 8ow &rade /"cell ly*pho*as
'. A&&ressi3e /"cell ly*pho*as
(. EK cell ly*pho*as
A
1$ A pre3iously healthy child presents with
palpa#le purpura: arthritis: and 3o*itin&. Sou
suspect a hypersensiti3ity 3asculitis
characteri;ed #y:
1. Peri3ascular 1&A
$. P"AECA autoanti#odies
%. 5ranulo*as and eosinophilia
'. 1n6ltration of destruction of 3essels
#y atypical ly*phocytoid and
plas*acytoid cells
(. Eectroti;in& &ranulo*atous
3asculitis
A
1% +fali;u*a# is an anti#ody which is directed
a&ainst 82A1 on the /"cell: #lockin& this
*oleculeGs interaction with:
1. C0'!
$. BA
%. 82A%
'. 1CAM"1
(. P"selectin
0
1' ,hat cytokine is *ost critical for the 1. 1nterleukin"$ C
1D
de3elop*ent and *aturation of eosinophils. $. 1nterleukin"'
%. 1nterleukin"(
'. 1nterferon"alpha
(. 1nterferon"&a**a
1( ,hich of the follwin& is a che*otactic factor
for eosinophils.
1. /E2
$. 18$
%. C(a
'. Plas*ino&en acti3ator
(. 18C
C
1) ,hen atte*ptin& to identify 8an&erhans cells
in a speci*en: which *arker is *ost helpful.
1. C01
$. C0'
%. C0A
'. C0C
(. C0$!
A
1A Su#acute cutaneous lupus erythe*atosus has
#een associated with the in&estion of which of
the followin& dru&s.
1. Phenytoin
$. Allopurinol
%. /er#ina6ne
'. /ri*ethopri*sulfa*etho<a;ole
(. Aurano6n
C
1C Anti"Ho =SS"A> anti#odies are *ost co**only
found in:
1. Mi<ed connecti3e tissue disease
$. +osinophilic fasciitis
%. 0ru&"induced syste*ic lupus
erythe*atosus
'. Fo*o;y&ous C$ de6ciency
(. Eeonatal lupus erythe*atosus
+
1D 9f the followin& co*ple*ent co*ponents: the
*ost powerful neutrophil che*oattractant is:
1. C%
$. C(a
%. C%a
'. C(#: C): CA: CC: CD
(. C'a
B
$! ,hich of the followin& suture *aterials
induces the least in-a**ation.
1. Sur&ical &ut
$. Poly&lycolic acid =0e<on>
%. Poly&lycan D1! =?icryl>
'. Polypropylene =Prolene>
(. Silk
0
$1 ,hich of the followin& /F$ cytokines is a B cell
&rowth factor.
1. 18"'
$. 18"(
%. 18"1!
'. 18"1%
(. 12E"&a**a
).
A
$$ /his skin disease has #een shown to #e
associated with reduced Beta $ defensin. /he
dia&nosis is:
1. Atopic der*atitis
$. Psoriasis
%. 8epro*atous leprosy
'. /u#erculoid leprosy
(. Su#acute cutaneous lupus
erythe*atosus
).
A
$% 8inear 1&A disease is *ost closely associated
with which of the followin& *edications.
1. +rythro*ycin
$. ?anco*ycin
%. Strepto*ycin
'. A;ithro*ycin
(. Clarithro*ycin
).
B
$' +osinophils are typically seen in the cutaneous
in6ltrate of:
1. Kra##eJs disease
$. Kaposifor* he*an&ioendothelio*a
%. KawasakiJs disease
'. Ki*uraJs disease
(. Ki"1 ly*pho*a
0
$( /his patient says the rash is spreadin& and not
controlled with topical therapy. Sou &i3e hi* a
course of oral treat*ent that lasts:
1. 1 week
$. $ weeks
%. % weeks
'. ' weeks
(. ( weeks
C
$) ,hich of the followin& diseases does E9/
respond with a /h1"type responses.
1. 8eish*aniasis which self"resol3es
$. 8epro*atous 8eprosy
B
$!
%. /u#erculoid 8eprosy
'. Aller&ic contact der*atitis
(. Psoriasis
$A An&iocentric EK/"cell ly*pho*a in children
*ay present as:
1. Papular acroder*atitis of childhood
$. Acropustulosis of infancy
%. Childhood der*ato*yositis
'. Fydroa 3accinifor*e
(. +n coup de sa#re
0
$C /he tar&et anti&en of chronic #ullous disease
of childhood is:
1. BPA5 1 D$%! kd BPA5>
$. DA kd 8A0"1 =a co*ponent of
BPA5$>
%. Colla&en type ?11
'. Alpha ) #eta ' inte&rin
(. Plectin
B
$D ,hich of the followin& i**uno&lo#ulin crosses
the placenta.
1. 1&A
$. 1&0
%. 1&+
'. 1&5
(. 1&M
0
%! Anti"centro*eric anti#odies are associated
with which rheu*atolo&ic disease.
1. CH+S/
$. Mi<ed connecti3e tissue disease
%. S8+
'. 0er*ato*yositispoly*yositis
(. Pro&ressi3e syste*ic sclerosis
A
%1 1n adult patients with Fenoch"SchJnlein
purpura with 1&A 3asculitis: which of the
followin& co*plications is *ost likely to occur.
1. Pul*onary he*orrha&e
$. Fe*orrha&ic cystitis
%. Peripheral neuropathy
'. Mesan&ial nephropathy
(. 2acial ede*a
0
%$ ,hich *onoclonal &a**opathy is *ost
co**only associated with erythe*a ele3atu*
diutinu*.
1. 1&A
$. 1&0
%. 1&+
'. 1&5
(. 1&M
A
%% Psoriasis aMects o3er $N of the worldJs
population and has a stron& association with
which F8A class 1 haplotype.
1. F8A"0H'
$. F8A"0H1
%. F8A"C,)
'. F8A"B$A
(. F8A"0Q)
C
%' 1*iLui*od induces which of the followin&
cytokines.
1. 1nterleukin"1!
$. 1nterferon"alpha
%. 1nterleukin"$
'. 1nterleukin"'
(. 1nterleukin"(
B
%( Fista*ine is a #iolo&ic a*ine produced #y
which of the followin& cells.
1. Monocytes
$. +osinophils
%. Basophils
'. Platelets
(. Basophils and Platelets
+
%) ,ith which F8A type is psoriasis *ost
de6niti3ely linked.
1. F8A"B(1
$. F8A"BC
%. F8A"0H'
'. F8A"0H%
(. F8A"Cw)
+
%A ,hich of the followin& F8A alleles is *ost
stron&ly associated with BehcetJs disease.
1. F8A"B$A
$. F8A"B(1
%. F8A"0Qw$
'. F8A"0H1
(. F8A"0H'
B
%C All of the followin& state*ents re&ardin& *a4or
histoco*pati#ility co*ple< *olecules are true
+OC+P/:
1. MFC class 11 *olecules #ind sta#ly
to peptides deri3ed fro* proteins
sythesi;ed and de&raded in the cytosol
$. MFC class 1 *olecules #earin& 3iral
peptides are reco&ni;ed #y cytoto<ic /"
cells that su#seLuently kill the infected
cell
%. Class 1 *olecules such as F8A"A: B:
A
$1
and C: are present on all nucleated cells
'. /he MFC is located on chro*oso*e
) in hu*ans
(. MFC Class 11 *olecules #earin&
peptides are reco&ni;ed #y /F1 or /F$
cells.
%D /he &ene for E+M9 =E2"kappa #ets essential
*odulator> is *utated in:
1. Papillon"8efJ3re syndro*e
$. Pachyonychia con&enital type 11
%. 0yskeratosis con&enital
'. EoonanJs syndro*e
(. 1ncontinentia pi&*enti
+
'! /opical tacroli*us and pi*ecroli*us are used
to treat atopic der*atitis and other
in-a**atory skin conditions. 9n which of the
followin& ions is the in-a**atory pathway
#locked #y these *edications dependent.
1. Sodiu*
$. Potassiu*
%. Calciu*
'. Seleniu*
(. Kinc
C
'1 ,hich of the followin& is a criterion for the
dia&nosis of BehcetGsdisease.
1. 1n-a**atory #owel disease
$. B3eitis
%. Con4uncti3itis
'. Easal septal perforation
(. 8o#ular panniculitis
B
'$ All of the followin& state*ents re&ardin&
Eatural Killer =EK> cells are true +OC+P/:
1. EK cells ha3e properties of innate
and acLuired i**unity
$. EK cells e<press C0 $ *olecules
%. EK cells are lar&e &ranular
ly*phocytes
'. EK cells *ediate tu*or lysis
(. EK cells *ediate lysis of 3iral"
infected cells
B
'% Ma4or histoco*pati#ility co*ple< class 1
*olecules #ind to:
1. Peptides deri3ed fro* proteins
synthesi;ed and de&raded in the cytosol
$. Peptides deri3ed fro* proteins
de&raded in endocytic 3esicles
%. Peptides e<ternal to the cell
*e*#rane
'. 1**uno&lo#ulin +
(. Eone of these answers are correct
A
'' ,hich cytokine is *ost i*portant in recruitin&
neutrophils.
1. 1nterleukin"1
$. 1nterleukin"$
%. 1nterleukin"'
'. 1nterleukin"C
(. 1nterleukin"1!
0
'( ,hich of the followin& dietary supple*ents
*ay inhi#it platelet function.
1. ?ita*in A
$. ?ita*in C
%. ?ita*in 0
'. ?ita*in +
(. ?ita*in K
0
') Sensation is intact in this lesion: #ut a 2ite
stain is positi3e. /his lesions is associated with
which of the followin&:
1. 18"'
$. 18"(
%. 18"1!
'. All of these answers are correct
(. Eone of these answers are correct
0
'A ,hich cytokine is predo*inantly responsi#le
for the 7arish"Fer<hei*er reaction.
1. /E2"alpha
$. 18"$
%. 18"(
'. 18")
(. 18"1$
A
'C All the followin& conditions e<hi#it a /"helper
cell 1 =/h1> cytokine secretion pro6le e<cept:
1. Psoriasis
$. Syste*ic lupus erythe*atosus
%. 5ranulo*atous leprosy
'. Hheu*atoid arthritis
(. Multiple sclerosis
B
'D All of the followin& state*ents re&ardin&
8an&erhans cells are true +OC+P/:
1. /hey are hi&hly pha&ocytic
$. /hey e<press C01 on their surface
%. /hey are found in so*e areas of
ly*ph nodes and spleen
'. /hey ha3e a hi&h density of Class 11
A
$$
*olecules on their surface
(. Eone of these answers are correct
(! ,hich of the followin& cytokines is a &eneral
down"re&ulator of /F1 i**unity.
1. 18"'
$. 18"(
%. 18"1!
'. /E2
(. 12E"&a**a
C
(1 All of the followin& stains can #e reacti3e in
this condition e<cept
1. C0O111a
$. C0%1
%. C0%'
'. Ble< europaeus
(. 2actor ?111"related anti&en
A
($ ,hich of the followin& is true of 8an&erhan
cells.
1. /hey are the pri*ary anti&en
presentin& cell in the epider*is
$. /hey are pri*arily in3ol3ed in the
innate i**une response
%. /hey do not e<press the C01a
*arker
'. /hey contain intranuclear #ir#eck
&ranules
(. /hey are increased on the pal*s:
soles: &enitalia: and #uccal *ucosa
A
(% /his wo*an should ha3e a workup for: 1. 8y*pho*a
$. Eephrolithiasis
%. Pancreatic cancer
'. Fe*ochro*atosis
(. /halasse*ia
0
(' ,hich of the followin& is associated with
hepatitis C infection.
1. +ssential *i<ed cryo&lo#uline*ia
$. Hheu*atoid arthritis
%. Helapsin& polychondritis
'. ,e&enerJs &ranulo*atosis
(. 0er*ato*yositis
A
(( /he phar*acolo&ic acti3ity of tacroli*us
includes:
1. Phosphorylation of E2A/ =nuclear
factor of transcription>
$. Bindin& and inhi#ition of E2 kappa B
%. 1nhi#ition of interleukin"1 &ene
transcription
'. Acti3ation of calcineurin
(. 1nhi#ition of interleukin"$ &ene
transcription
+
() Proteins in the alternate co*ple*ent pathway
include:
1. 2actor B
$. properdin
%. C%
'. 2actor B and properdin
(. 2actor B: properdin and C%
+
(A All of the followin& state*ents re&ardin& *ast
cells are true +OC+P/:
1. Mast cells reside near s*all #lood
3essels
$. Mast cells protect *ucosal surfaces
a&ainst patho&ens
%. Mast cells release su#stances that
aMect 3ascular per*ea#ility
'. Mast cells ha3e receptors for certain
fra&*ents of co*ple*ent on their
surface
(. Eone of the a#o3e =all are true>
+
(C ,hich of the followin& i**une"*ediated
e3ents has #een de*onstrated in psoriasis
3ul&aris.
1. Clonal e<pansion of C0CP / cells
$. 0ecrease der*al 8an&erhans cells
%. 0ownre&ulation of keratin 1)
'. 1ncrease /h$ C0'P / cells
(. 0ecreased production of interferon"
&a**a
A
(D ,hich cytokine is che*otactic for neutrophils. 1. 18"$
$. 18"%
%. 18"(
'. 18")
(. 18"C
+
)! All of the followin& state*ents re&ardin& 1. EeutrophilsG *a4or function is A
$%
neutrophils are true +OC+P/: anti&en presentation
$. Eeutrophils ha3e receptors for 1&5
and co*ple*ent
%. Eeutrophils are &ranulocytes
'. Eeutrophils are the *ost a#undant
leukocytes
(. Eone of these answers are correct
)1 Calcipotriene"induced i*pro3e*ent in
psoriasis is associated with increased lesional
le3els of which cytokine.
1. 1nterleukin"$
$. 1nterleukin"C
%. /u*or necrosis factor
'. 1nterleukin"1!
(. 1nterluekin"1$
0
)$ Pe*phi&us is associated with which F8A
type=s>.
1. F8A"0Hw)
$. F8A"BC
%. F8A"B(1
'. All of these answers are correct
(. Eone of these answers are correct
A
)% ,hich cytokine is not upre&ulated in atopic
der*atitis patients.
1. 18"1%
$. 18"'
%. 18"(
'. 18"1!
(. 12E"&a**a
+
)' Purpuric contact der*atitis is *ost likely to #e
associated with:
1. Eickel
$. 2or*aldehyde
%. P"phenylenedia*ine
'. Propylene &lycol
(. Sor#ic acid
B
)( Seru* 1&A anti#odies to tissue
trans&luta*inase occur in:
1. Bullous pe*phi&oid
$. 8inear 1&A disease
%. Pe*phi&us foliaceus
'. Bullous lupus erythe*atosus
(. 0er*atitis herpetifor*is
+
)) 0er*atitis herpetifor*is is associated with
which F8A type=s>.
1. F8A"BC
$. F8A"0H%
%. F8A"0Qw$
'. All of the a#o3e
(. Eone of the a#o3e
0
)A ,hich of the followin& #est descri#es the
*echanis* of action for in-i<i*a#.
1. 1nhi#ition of calcineurin"*ediated
dephosphorylation of transcription
factors
$. 1nhi#ition of retinoic acid '"
hydro<ylase acti3ity
%. 1nhi#ition of tu*or necrosis factor
alpha acti3ity
'. Selecti3e eli*ination of acti3ated /
cells 3ia #indin& to hi&h aTnity 18"$
receptor
(. Selecti3e /"cell up"re&ulation of 18"'
and 18"( production
C
)C ,hich co**on contact aller&en is detected
3ia the di*ethyl&lyo<i*e test.
1. Ben;ocaine
$. Chro*ates
%. 2or*aldehyde
'. Eickel
(. Hhus
0
)D /his disease is *ost associated with: 1. 5a**a interferon
$. 18"'
%. 18"(
'. 18"1%
(. Eone of these answers are correct
A
A! /oll"like receptors =/8Hs> ha3e #een found to
play an i*portant role in innate i**unity. /his
has #een utili;ed in the de3elop*ent of
*edications freLuently used in der*atolo&y.
/he *echanis* of what *edication in3ol3es
acti3ation of /8HA.
1. Clo#etasol
$. /acroli*us
%. Cyclosporine
'. ("2luorouracil =("2B>
(. 1*iLui*od
+
A1 MFC Class 11 *olecules are present on which of
the followin& cell types:
1. B cells
$. / cells
A
$'
%. EK cells
'. Mast cells
(. All of the a#o3e
A$ ,hich cytokine is upre&ulated in lesions of
tu#erculoid leprosy.
1. 18 $
$. 18 '
%. 18 (
'. 18 1!
(. Eone of the answers are correct
A
A% /his patient recently de3eloped this rash. Sou
decide to patch test her: #ut in the *eanwhile
you tell her to a3oid:
1. Cha*o*ile
$. Pri*in
%. A#ietic acid
'. Ben;ocaine
(. Cinna*on
+
A' An C *onth"old #a#y with diMuse purpura is
ad*itted to the hospital for her third episode
of #acterial *enin&itis. ,hich co*ponent of
her i**une syste* is i*paired.
1. C0' P / cells
$. Eatural killer cell acti3ation
%. C0C P / cells
'. Co*ple*ent acti3ation
(. Anti#ody production
0
A( /he *ost useful pair of i**unohistoche*ical
stains to distin&uish #etween 0er*ato6#ro*a
protu#erans =02SP> and a 6#rous histiocyto*a
would #e:
1. Synaptophysin: chro*o&ranin
$. C0%': factor O111a
%. C0%': C0%1
'. C0%1: C0%
(. ?i*entin: synaptophysin
B
A) Eai3e / cells e<press which of the followin&
surface *olecules:
1. C01D
$. C0$!
%. C0AD
'. C0'(H9
(. C0'(HA
+
AA ,hich cytokine is up"re&ulated in this
&eo*etric: ec;e*atous der*atitis.
1. 18"$
$. 18"'
%. 18"(
'. 18"A
(. 18"1!
A
AC ,hich of the followin& is an e<a*ple of a
delayed hypersensiti3ity reaction.
1. Aller&ic contact der*atitis
$. Anaphyla<is
%. 8ate< aller&y
'. /ransfusion reaction
(. Seru* sickness
A
AD ,hich syste*ic anti"in-a**atory a&ent
speci6cally #locks the a#ility of / cells to lea3e
the 3asculature and enter the skin.
1. +tanercept
$. 1n-i<i*a#
%. +fali;u*a#
'. Alefacept
(. Eone of the a#o3e
C
C! Helapsin& polychondritis is an autoi**une
disease associated with i**unity to which
type of colla&en.
1. 1
$. 11
%. 111
'. 1?
(. ?11
B
C1 A $) year"old *an presents with a history of
recurrent episodes of tar&etoid: erythe*atous:
ede*atous *acules: patches: and plaLues on
the ar*s: le&s: pal*s: and soles. /he *ost
likely etiolo&ic a&ent is:
1. Par3o3irus B1D
$. Ferpes si*ple< 3irus
%. Co<sackie3irus
'. Cyto*e&alo3irus
(. Fu*an i**unode6ciency 3irus
B
C$ /he endothelial li&and for cutaneous
ly*phocyte anti&en =C8A> is:
1. 1ntercellular adhesion *olecule 1
=1CAM"1>
$. 8"selectin
%. +"selectin
'. ?ascular cell adhesion *olecule
=?CAM"1>
(. 8eukocyte functional anti&en =82A %>
C
C% 5ene rearran&e*ent analysis is usedful for
deter*inin&:
1. 8y*phocyte clonality in *ycosis
fun&oides
$. 8y*phocyte acti3ity
%. 5ene 2unction
'. 5ene Mutations
(. / cell receptor status
A
C' /he *ost de6niti3e F8A association with 1. F8A"Cw) A
$(
psoriasis is: $. F8A"B$A
%. F8A"B1%
'. F8A"B1A
(. F8A"B%A
C( Aller&ic contact der*atitis is caused #y /"cell
response to topical e<posure to co*pounds
that for* co*ple<es with host proteins
=haptens>. ,hich cell is responsi#le for initial
sensiti;ation of the /"cells.
1. Melanocyte
$. 8an&erhans Cell
%. B"cell
'. Mast Cell
(. Macropha&e
B
C) ,hich of the followin& causes a photoaller&ic
contact der*atitis that is e<acer#ated #y B?A
radiation.
1. Ascor#ic acid
$. /itaniu* dio<ide
%. 9<y#en;one
'. Kinc o<ide
(. 0ihydro<yacetone
C
CA /his patient has a licheni6ed plaLue in the
lower *id a#do*en as well as these two
e<c;e*atous plaLues. /his patient needs:
1. Patch testin&
$. A steroid
%. An anti3iral
'. A K9F scrapin&
(. An antifun&al
A
CC ,hich cytokine is responsi#le for acti3atin&
natural killer cells.
1. 1nterleukin '
$. 1nterleukin $
%. 1nterferon"alpha
'. /erferon"&a**a
(. /u*or necrosis factor"alpha
B
CD /he classical co*ple*ent pathway: 1. Can #e acti3ated in the a#sence of
anti#ody
$. Can #e acti3ated #y 1&5'
%. Can #e acti3ated #y 1&M
'. 1ncludes C% and factor B
(. 0oes not cause *e*#rane da*a&e
C
D! Psoriatic arthritis is *ost co**only associated
with which F8A.
1. F8A"B$A
$. F8A"Cw)
%. F8A"Aw1D
'. F8A"Bw%(
(. Eone of these options are correct
A
D1 ,hich of the followin& su#stances is located in
the core of an eosinophil.
1. +osinophilic cationic protein
$. +osinophil"deri3ed neuroto<in
%. +osinophil pero<idase
'. Ma4or #asic protein
(. Chy*ase
).
0
D$ ,hich co*ponent of the / cell receptor is
associated with superanti&en reco&nition.
1. 0"#eta
$. 7"alpha
%. 7"#eta
'. ?"alpha
(. ?"#eta
+
D% ,hich of the followin& is the tar&et anti&en in
pe*phi&us 3ul&aris.
1. 0es*o&lein %
$. 0es*oplakin
%. Cadherin
'. /ype O?11 colla&en
(. 0es*o&lein 1
A
D' A *ale infant presents with thro*#ocytopenia:
ec;e*a: and recurrent infections. Sou suspect
which of the followin& i**unode6ciency
disorders.
1. Ata<ia telan&iectasia
$. 0i"5eor&e ano*aly
%. Fyper"1&M syndro*e
'. 8einerX Ys disease
(. ,iskott"Aldrich syndro*e
+
D( Anti"epili&rin =la*inin (> anti#odies *ay #e
seen in:
1. Pe*phi&oid &estationis
$. Pe*phi&us 3e&etans
%. 2o&o sel3a&e*
'. Cicatricial pe*phi&oid
(. Paraneoplastic pe*phi&us
0
D) All of the followin& state*ents re&ardin& /oll
receptors are true +OC+P/:
1. /oll receptors are present on
*acropha&es and dendritic cells
$. /oll $ receptors are typically
acti3ated #y lipopolysaccharide
%. /oll ' receptors are typically
acti3ated #y &ra* ne&ati3e #acteria
B
$)
'. Euclear factor kappa B =E2KB> is the
6nal co**on pathway of toll receptors
(. Eone of the a#o3e =all are true>
DA 2or this patient: you reLuest that the la#
perfor* indirect i**uno-uorescence usin&
what su#strate.
1. Monkey esopha&us
$. Hat #ladder
%. 5uinea pi& esopha&us
'. Mouse epitheliu*
(. Fep"$ cells
C
DC ,hich of the followin& cytokines: to&ether with
18"': pro*otes isotype switchin& fro* 1&M to
1&+.
1. 18"(
$. 18"1!
%. 18"1%
'. /E2
(. 12E"&a**a
C
DD /he i**uno&lo#ulin *ost co**only found in
*ucous secretions is:
1. 1&A
$. 1&0
%. 1&+
'. 1&5
(. 1&M
A
1!
!
/"cell aner&y occurs if: 1. Sti*ulation #y a MFC Class 111
*olecule is in3ol3ed
$. MFC/CH en&a&e*ent occurs
without costi*ulatory *olecules
%. 2as8 is #ound on the /"cell
'. MFC Class 1 or 11 is #ound in the
presence of 18"$
(. A F8A"0M facilitator is not in3ol3ed
with the #indin&
B
1!
1
,hich is not a feature of *ast cells. 1. +<presses c"kit
$. Hesponds to HAE/+S
%. Produces 18"C
'. Produces prosta&landin 0$
(. Stains with napththol chloro"acetate
esterase
B
1!
$
+la#oration of which of the followin& cytokines
is characteristic of /F$ response.
1. 1nterferon"C =&a**a>
$. 1nterleukin"1
%. 1nterleukin"$
'. 1nterleukin"'
(. 1nterleukin"1$
0
1!
%
0er*atitis Ferpetifor*is is *ost co**only
associated with which F8A.
1. F8A"0H%
$. F8A"B$A
%. F8A"BC
'. F8A"Bw%(
(. F8A"0Q=A1Z!(!1: B1Z!$>
+
1!
'
Keratinocytes e<press what class of *a4or
histoco*pati#ility co*ple< under nor*al
conditions.
1. MFC Class 1
$. MFC Class 11
%. MFC Class 111
'. MFC Class 1?
(. MFC Class ?
A
1!
(
A de6ciency of this co*ple*ent co*ponent
*ay result clinically in suscepti#ility to
pyo&enic infections: &lo*erulonephritis: and
partial lipodystrophy:
1. C1 +sterase 1nhi#itor
$. C%
%. C'
'. C(!
(. Properidin
B
1!
)
,hich anti#ody is *ost co**only found in
circulation of patients with atopic der*atitis.
1. 1&A
$. 1&0
%. 1&+
'. 1&5
(. 1&M
C
1!
A
,hich of the followin& i**uno&lo#ulins
cannot acti3ate the co*ple*ent pathway.
1. 1&M
$. 1&51
%. 1&5$
'. 1&5%
(. 1&5'
+
1!
C
/he *a4or histoco*pati#ility co*ple<
=MFC>consists of a linked set of &enes
encodin& for MFC Class 1: Class 11: Class 111: and
Class 1B. ,hich of the followin& isare true:
1. Class 11 *olecules are present on all
nucleated cells
$. Class 1 *olecules are present on
erythrocytes
0
$A
%. Class 1 *olecules are e<pressed on
BC cells: *onocytes and dendritic cells
'. /he le3el of Class 1 and 11 e<pression
can #e *odulated #y cytokines
(. /he MFC re&ion is located on
chro*oso*e 1A in hu*ans
1!
D
All of the followin& state*ents are true
re&ardin& cells of the innate i**une syste*
+OC+P/:
1. Eeutrophils ha3e receptors for 1&5
$. Basophils are a type of &ranulocyte:
as are neutrophils
%. 18"( downre&ulates the functions of
eosinophils
'. 8an&erhans cells are poorly
pha&ocytic
(. 8an&erhans cells e<press C01 on
their surface
C
11
!
/his patient de3eloped an acute 3esicular rash
after eatin& a *an&o. She has returned for a
routine follow"up. She needs to #e careful of
e<posure to:
1. 5ink&o fruit
$. Croton
%. Ha&weed
'. /ea tree oil
(. All of these answers are correct
A
11
1
,hich anti#ody can #ind the 2c+H1 portion of
*ast cells: #asophils: 8an&erhans cells: der*al
dendritic cells.
1. 1&A
$. 1&0
%. 1&+
'. 1&5
(. 1&M
C
11
$
,hich paraprotein is found *ost co**only in
patients with pyoder*a &an&renosu*.
1. 1&5
$. 1&A
%. 1&M
'. 1&+
(. 1&0
B
11
%
/he hu*an *a4or histoco*pati#ility co*ple<
=MFC> is located on chro*oso*e:
1. $
$. )
%. D
'. 11
(. 1A
B
11
'
Chronic idiopathic urticaria is associated with
which F8A type=s>.
1. F8A"0H'
$. F8A"0HB' (%
%. F8A"0QC
'. all of the a#o3e
(. none of the a#o3e
0
11
(
A 3ery co**on pentadecacatechol sensiti;er
is found in all of the followin& plantsplant
co*ponents e<cept:
1. 5in&ko fruit pulp
$. Poison su*ac
%. Man&o fruit pulp
'. Cashew oil
(. 1ndian *arkin& nut oleoresin
C
11
)
,hich of the followin& features of 1&5 is true. 1. 1&5 is not an opsoni;in& anti#ody
$. 1&5 is the only class of
i**uno&lo#ulin that can pass throu&h
the placenta
%. 1&5 cannot acti3ate the co*ple*ent
cascade
'. 1&5 represents 1(N of the total
protein in seru*
(. 1&5 is the second i**uno&lo#ulin
synthesi;ed #y the fetus
B
11
A
Patients with a type 1 reaction to late< *ay
ha3e cross"reactions with which of the
followin& foods.
1. A3ocado
$. Forseradish
%. Cashews
'. Parsnips
(. 5arlic
A
11
C
Eatural killer =EK> cells eli*inate infected cells
in all of the followin& ways e<cept:
1. EK cells adhere to and kill tar&et
cells coated with 1&5
$. EK cells secrete perforins
%. EK cells secrete &ran;y*e
'. EK cells secrete *yelopero<idase
(. EK cells do not tar&et cells
e<pressin& *a4or histoco*pati#ility
0
$C
=MFC> class 1 *olecules
11
D
/he *ost likely tar&et for e<foliati3e to<in A in
#ullous i*peti&o is:
1. 0es*o&lein %
$. 8a*inin (
%. 0es*o&lein 1
'. Colla&en ?11
(. Ces*ocollin
C
1$
!
,hich of the followin& B cell receptors is
in3ol3ed in i**uno&lo#ulin isotype switchin&.
1. C0'!
$. C01D
%. C0$!
'. C01('
(. C0$$
A
1$
1
,hat is the #est screenin& test for hereditary
an&ioede*a.
1. C1 esterase
$. C'
%. CF(!
'. C$
(. C%
B
1$
$
/he *ain cytokine secreted #y /h1 C0CP
eMector /"cells is:
1. 18"1
$. 18"$
%. 12E"&a**a
'. 18"'
(. 18"(
C
1$
%
,hich cytokine is pri*arily responsi#le for
sti*ulation of neutrophils.
1. 18"1
$. 18"'
%. 18"(
'. 18")
(. 18"C
+
1$
'
/he anti#ody produced in the early sta&es of
anti#ody responses is:
1. 1&A
$. 1&0
%. 1&+
'. 1&5
(. 1&M
+
1$
(
/his lesion is hypoesthetic and is associated
with which of the followin&:
1. 5a**a interferon
$. 1nterleukin $
%. 1nterleukin 1$
'. All of these answers are correct
(. Eone of these answers are correct
0
1$
)
Mononuclear pha&ocytes residin& in tissues: 1. Are called *acropha&es
$. Pha&ocytose forei&n anti&ens and
de&rade the* into peptides
%. Present anti&en to /"cells
'. Produce cytokines: which recruit
other in-a**atory cells
(. All of the a#o3e
+
1$
A
,hich syste*ic anti"in-a**atory a&ent
tar&ets C0$P acti3ated / cells for apoptosis.
1. +tanercept
$. 1n-i<i*a#
%. +fali;u*a#
'. Alefacept
(. Eone of the a#o3e
0
1$
C
,hich cytokine is responsi#le for fe3er in
patients with sun#urn.
1. 18"1
$. 18"(
%. 18"1!
'. 18"11
(. /E2"#eta
A
1$
D
/his patient had anti#odies to 1C! kd anti&en.
/he likely dia&nosis is:
1. Bullous pe*phi&oid
$. Pe*phi&us 3ul&aris
%. Pe*phi&us foliaceous
'. +rythe*a *ultifor*e
(. Bullous lichen planus
A
1%
!
Anti 7o"1 anti#odies are directed a&ainst which
of the followin&.
1. /opoiso*erase
$. 8ysyl o<idase
%. 5yrase
'. Fistidyl transfer HEA synthetase
(. /elo*erase
0
1%
1
Ferpes &estationis is *ost co**only
associated with which F8A.
1. F8A"0H%
$. F8A"B$A
%. F8A"B(1
'. F8A"0HD
A
$D
(. F8A"0QC
1%
$
/he putati3e *echanis* of action of topical
*acrolide i**uno*odulators is inhi#ition of:
1. 8y*phokine production
$. Prosta&landin secretion
%. Anti&en presentation
'. Eeutrophil *i&ration
(. 8y*phocyte *i&ration
A
1%
%
A patient had anti#odies to des*o&lein %: #ut
no anti#odies to des*o&lein 1 or des*plakin.
/he likely dia&nosis is:
1. Pe*phi&us 3ul&aris
$. Pe*phi&us foliaceous
%. Bullous pe*phi&oid
'. 0er*atitis herpetifor*is
(. +rythe*a *ultifor*e
A
%. 5enoder*atoses
# Question Answers A
1 Mucosal neuro*as:
pheochro*ocyto*a and *edullary
thyroid carcino*a in a patient with a
*arfanoid #ody ha#itus is associated
with which of the followin& &ene
defects.
1. Menin
$. H+/ proto"onco&ene
%. P/+E
'. BF0
(. S/K11
B
$ ,hich of the followin& syndro*es is
associated with he*atolo&ic
a#nor*alities.
1. Stur&e ,e#er disease
$. Klippel"/renaunay"Parks",e#er
%. Kasa#ach"Merritt syndro*e
'. Blue ru##er #le# ne3us
syndro*e
(. Bloo*Js syndro*e
C
% /he 6ndin& of G*altese crossesG in the 1. Alkaptonuria B
%!
urine is characteristic of which of the
followin& conditions.
$. 2a#ry disease
%. 5aucher disease
'. Eei*ann"Pick disease
(. Funter syndro*e
' ,hich of the followin&
i**uno&lo#ulins is co**only
decreased in ,iskott"Aldrich
syndro*e.
1. 1&A
$. 1&0
%. 1&+
'. 1&M
(. 1&5
0
( /he nucleotide e<cision 0EA repair
pathway is defecti3e in which disease:
1. Bourne3illeGs disease
$. Se3ere co*#ined de6ciency
syndro*e
%. 5riscelli syndro*e
'. Oeroder*a pi&*entosa
(. S4o&ren"8arssen syndro*e
0
) ,hich type of epider*olysis #ullosa
si*ple< is associated with early death.
1. ,e#er"Cockayne
$. 5enerali;ed =Koe#ner>
%. 0owlin&"Maera
'. 9&na 3ariant
(. Eon"Ferlit; 3ariant
).
C
A Mosaic *utations in P/+E are seen in
which of the followin& conditions.
1. 5ardner syndro*e
$. Proteus syndro*e
%. 1ncontinentia pi&*enti
'. Eoonan syndro*e
(. Beckwith",ieder*an syndro*e
).
B
C ,hich of the followin& is a feature of
Eeuro6#ro*atosis type 11.
1. Con&enital hypertrophy of the
retinal pi&*ent epitheliu*
$. 8isch nodules
%. 7u3enile posterior su#capsular
lenticular opacities
'. 8ester iris
(. 9ptic &lio*as
C
D A patient with colon cancer is
dia&nosed with Muir"/orre syndro*e.
,hich of the followin& cutaneous
lesions *i&ht the patient ha3e.
1. Keratoacantho*as
$. Se#orrheic keratoses
%. /richole**o*as
'. Arsenical keratoses
(. Basal cell carcino*as
).
A
1! An infant with dou&hy: redundant skin
and short sparse hairs is likely to show
which features on <"ray.
1. Metaphyseal widenin& in the
lon& #ones
$. Sphenoid win& dysplasia
%. Periosteal thickenin&
'. 9steopoikilosis
(. Stippled epiphyses
A
11 ,hich ocular 6ndin& *ay #e seen in a
patient with this skin condition.
1. Co**a"shaped corneal
opacities
$. Hetinitis pi&*entosa
%. Con&enital hypertrophy of the
retinal pi&*ented epitheliu*
'. An&ioid streaks
(. Pin&ueculae
0
1$ Fo*ocystinuria is caused #y a defect
in:
1. Phenylalanine hydro<ylase
$. Biotinidase
0
%1
%. Folocar#o<ylase synthetase
'. Cystathione #eta"synthetase
(. 5pD1"pho<
1% A patient with *elano*a and a
*ali&nant &lio*a is dia&nosed with 8i"
2rau*eni syndro*e. ,hich of the
followin& tu*ors occurs *ost
freLuently in this disease.
1. Hha#do*yosarco*a
$. Adrenocortical carcino*a
%. 8un& carcino*a
'. Breast carcino*a
(. 8euke*ia
A
1' ,hich keratins are e<pressed in the
supra#asal pal*oplantar epider*is.
1. Keratins 1 and D
$. Keratins 1 and 1!
%. Keratins ' and 1%
'. Keratins ( and 1'
(. Keratins C and 1C
A
1( /he *ain cause of death in patients
with dyskeratosis con&enita is which of
the followin&.
1. 9ral sLua*ous cell carcino*a
$. 8euke*ia
%. Henal cell carcino*a
'. Pancytopenia
(. Atherosclerotic heart disease
0
1) ,hat is the classic radiolo&ic 6ndin&s
associated with this disorder.
1. 0ural calci6cations
$. Calci6cations of the fal<"cere#ri
%. /ra*"track calci6cations of the
te*poral and occipital corte<
'. 9steopatha striata
(. 9steopoikilosis
C
1A A % year"old #oy presents with the
6ndin&s seen in the i*a&e. Fe also has
thro*#ocytopenia with purpura and a
history of recurrent pyo&enic #acterial
infections. ,hat is the *ost likely
dia&nosis in this child.
1. Chronic 5ranulo*atous disease
$. ,iskott"Aldrich syndro*e
%. Fyper"1&+ syndro*e
'. Se3ere co*#ined
i**unode6ciency
(. 8einer syndro*e
B
1C ,hich of the followin& condition is E9/
found in ?on"Fippel 8indau syndro*e.
1. Connecti3e tissue ne3i
$. Bilateral retinal
he*an&io#lasto*as
%. Cere#ellarCES
he*an&io#lasto*as
'. Henal cell carcino*a
(. Pheochro*ocyto*a
A
1D ,hat is the *ost co**on ocular
6ndin&s seen in this condition.
1. An&ioid streaks
$. Phako*as
%. 8isch nodules
'. Bitot[s spots
(. Colo#o*a
A
$! A patient with CroweJs si&n and an
optic &lio*a has which of the followin&
disorders.
1. Eeuro6#ro*atosis 1
$. Eeuro6#ro*atosis 11
%. ,atson syndro*e
'. /u#erous sclerosis
(. 8ester iris syndro*e
A
$1 MaMucci syndro*e is has
characteristic 3enous *alfor*ations of
the distal e<tre*ities and #eni&n
endochondro*as which can
co*pro*ise #one stren&th and lead to
chondrosarco*as. /he defect causin&
this #elie3ed to #e the P/FP/FrP type
1 receptor which is inherited in which
1. Sporadic
$. Autoso*al do*inant
%. Autoso*al recessi3e
'. O"linked do*inant
(. O"linked recessi3e
A
%$
*anner.
$$ ,hich cutaneous 6ndin& is seen in
patients with phenylketonuria.
1. An&ular sto*atitis
$. 1chthyosis
%. Pi&*ent dilution of hair and
skin
'. Phyrnoder*a
(. +rosi3e diaper der*atitis
C
$% A patient with renal cell carcino*a
caused #y *utations in fu*arate
hydratase de6ciency likely suMers
which of the followin& conditions.
1. ?on"Fippel"8indau syndro*e
$. Cowden syndro*e
%. Birt"Fo&&"0u#e syndro*e
'. 2a*ilial *ultiple cutaneous
leio*yo*atosis
(. Multiple endocrine neoplasia
0
$' A patient presents with focal
sy**etric pal*oplantar keratoder*a:
thickened: hyperkeratotic 6n&ernails
and toenails with a IpincerI
appearance and freLuent staph and
candida paronychial infections:
follicular hyperkeratosis of the knees
and el#ows and oral leukokeratosis.
/he patients *other and &randfather
#oth ha3e si*ilar skin 6ndin&s. ,hich
syndro*e is descri#ed.
1. 7adassohn"8ewandowsky
syndro*e
$. 7ackson"8awler syndro*e
%. Schafer"Branauer syndro*e
'. Pachyonychia con&enita tarda
(. Eone of the options are correct
A
$( An infant &irl of short stature and
shortened 'th and (th *etacarpals is
#ein& e3aluated for coarctation of the
aorta and horseshoe kidneys. Physical
e<a*ination *ost likely re3eals:
1. ,e##ed neck
$. Alopecia
%. Fe*an&io*a
'. 5iant con&enital *elanocytic
ne3us
(. Arachnodactyly
A
$) A patient with $! nail dystrophy:
steatocysto*a *ultiple< and natal
teeth likely has a *utation in the
&enes codin& for:
1. Keratins (
$. 8a*inin (
%. Plakophilin 1
'. Keratins )# @ 1A
(. Keratins ) @1)
0
$A 8ow"cystine content in hair and nails
*ay contri#ute to the phenotype seen
in:
1. ,ilsonJs disease
$. MenkeJs Kinky Fair syndro*e
%. /ay Syndro*e
'. Eethertons
(. B4ornstad
C
$C +pider*olysis #ullosa with *uscular
dystrophy is caused #y *utations in
which of the followin&.
1. Keratins ( and 1'
$. Plectin
%. 8oricrin
'. Colla&en A
(. Colla&en 1A
B
$D ,hich of the followin& hereditary skin
disorders is associated with the HAS"
+HK"MAPK pathway.
1. Costello syndro*e
$. Hoth*und"/ho*pson Syndro*e
%. Carney co*ple<
'. /u#erous Sclerosis
(. 5riscelli syndro*e
A
%! ,hat &ene defect would you e<pect to
6nd in a child with white forelock:
dystopia canthoru*: and upper li*#
a#nor*alities.
1. Pa<%
$. M1/2
%. S9O1!
'. +ndothelin"%
(. C"kit proto"onco&ene
A
%%
%1 Bnderlyin& defect for the disease
shown in picture is
1. A/P$A$
$. A/P$C1
%. BPA51
'. BPA5$
(. Colla&en type 1A
B
%$ 0ental ena*el pits are seen in which
of the followin& conditions.
1. Fypo*elanosis of 1to
$. 8etterer"Siwe disease
%. /u#erous sclerosis
'. 7ackson Sertoli syndro*e
(. Fyper"1&+ syndro*e
C
%% Hefsu* syndro*e is due to a
de6ciency in phytanyl coen;y*e A
hydro<ylase. /reat*ent for this
condition is:
1. 0iet low in &reen 3e&eta#les:
dairy and ru*inant fats
$. 0iet hi&h in &reen 3e&eta#les:
dairy and ru*inant fats
%. +n;y*e replace*ent
'. Eo treat*ent is a3aila#le at this
ti*e
(. A3oid phenylalanine
A
%' A 1) year"old &irl presents with a
fa*ily history of 5ardner syndro*e.
Fer *other is 3ery concerned that her
dau&hter *ay ha3e the syndro*e as it
runs in her fa*ily and she has *any
skin co*plaints. 5ardner syndro*e
has #een linked to defects in #eta"
catenin *ediated transcription. ,hich
of the followin& ocular 6ndin& is
dia&nostic for 5ardner syndro*e.
1. 8isch nodules
$. 8ester iris
%. Con&enital Fypertrophy of the
Hetinal Pi&*ent +pitheliu*
'. An&ioid streaks
(. Hetinal detach*ent
C
%( A teena&e fe*ale presents with the
co*plaint of Inail fun&usI. 9n e<a*:
she has trian&ular lunulae:
pal*oplantar hyperhidrosis:
*icronychia and an a#sent patella.
,hich of the followin& screenin& tests
should you order 6rst.
1. Brinalysis
$. CBC
%. 2astin& lipids
'. Henal ultrasound
(. O"ray of the knees: el#ows and
pel3is
A
%) Mutation in la*in A =nuclear en3elope
protein> has #een found in:
1. Peut;"7e&hers syndro*e
$. Buschek"9llendorf syndro*e
%. Pro&eria =Futchinson"5ilford>
'. Al#ri&htJs syndro*e
(. Marfan syndro*e
C
%A 1n chronic &ranulo*atous disease: the
dia&nosis is *ade #y which of the
followin& tests.
1. Assay for fu*arate hydratase
$. Eitro#lue tetra;oliu* reduction
assay
%. Assay for sphin&o*yelinase
'. Skin #iopsy
(. Assay for &lucocere#rosidase
B
%C A %"year old #oy has freLuent
a#scesses: chronic ear infections: and
se3ere ec;e*a. Fe has an older
#rother with si*ilar pro#le*s. ,hat is
the &ene *utation.
1. Stat % &ene
$. 2B8E ( &ene
%. 18$ receptor &ene
'. 8+M0% &ene
(. ,AS &ene
A
%D Hetinal he*an&io#lasto*as are found
in which syndro*e:
1. 9sler",e#er"Hendu disease
$. ?on"Fippel 8indau disease
%. Kasa#ach"Merritt syndro*e
'. Klippel"/renaunay ,e#er
B
%'
syndro*e
(. Stur&e",e#er syndro*e
'! A 11 year"old fe*ale patient with
hypoparathyroidis* is referred to your
clinic secondary to chronic
*ucocutanous candidiasis which is
refractory to standard treat*ents. /he
patient also has *ala#sorption and
se3ere chronic diarrhea. Sou deter*ine
that she has autoi**une
polyendocrinopathy"candiasis"
ectoder*al dystrophy
syndro*e=AP+C+0>. ,hat is the &ene
defect for AP+C+0.
1. OAP1!1 &ene
$. A1H+ &ene
%. C51"(C &ene
'. A89O &ene
(. PAFO &ene
B
'1 /he <"linked recessi3e type of
dyskeratosis con&enita is:
1. 0yskerin
$. /+HC
%. C0KE$A
'. P/+E
(. Menin
).
A
'$ ,hich &enetic defect could e<plain
cutaneous 6ndin&s in addition to
a#nor*al i**uno&lo#ulin le3els:
recurrent respiratory infections:
hypo&onadis*: and an increased risk
of leuke*ia and ly*pho*a.
1. HecQ8%
$. +HCC)
%. ,AS &ene
'. EA0PF o<idase
(. Adenosine dea*inase
).
A
'% Most co**on *ali&nancy to de3elop
in a patient with trichole**o*as:
acral 3errucous papules and co##le"
stonin& of #uccal and &in&i3al *ucosa.
1. /hyroid cancer
$. Breast cancer
%. Colon cancer
'. 8y*pho*a
(. Melano*a
B
'' /he *ost co**on cutaneous
neoplas* associated with Muir /orre
Syndro*e is:
1. Se#aceous carcino*a
$. Se#aceous adeno*a
%. Keratoacantho*a
'. Basal cell carcino*a with
se#aceous diMerentiation
(. SLua*ous cell carcino*as
B
'( /he *ost co**on cutaneous
association with *onilethri< is:
1. +c;e*a
$. Fypopi&*entation
%. Fyperpi&*entation
'. Keratosis Pilaris
(. Atrophy
0
') A $!"year old *ale with a history of
pheochro*ocyto*a and *edullary
thyroid cancer presents with *ucosal
papules. Fis o3erall #ody appearance
is *ost likely to de*onstrate:
1. Cushin&oid features
$. Marfanoid features
%. Short stature
'. 8ipodystrophy
(. Bnilateral li*# shortenin&
B
'A An infant presents with poikiloder*a
on his face: #uttocks: ar*s and le&s.
Fe is also noted to ha3e a hypoplastic
thu*# and no radius. Searly
ophthal*olo&ic e<a*ination is
indicated #ecause of the infant is at
risk for de3elopin&:
1. 5lauco*a
$. Cataracts
%. Su#capsular lens displace*ent
'. Copper deposition
(. Macular de&eneration
B
'C /he co*#ination of &astrointestinal 1. Eicolau"Balus syndro*e C
%(
polyposis: nail atrophy: alopecia:
&enerali;ed pi&*entation of skin: and
*elanotic *acules of the 6n&ers is
characteristic of which of the followin&
syndro*es.
$. Peut;"7e&hers syndro*e
%. Cronkhite"Canada syndro*e
'. Cowden syndro*e
(. Bannayan"Hiley"Hu3alca#a
syndro*e
'D ,hat phenotype results fro* a low
acti3ity of dou#le stranded HEA
adenosine dea*inase.
1. ,aarden#er&Gs syndro*e type
$
$. Pie#aldis*
%. /iet; syndro*e
'. dyschro*atosis sy**etrica
hereditaria
(. oculocutaneous al#inis* type '
0
(! Anodontia is a #one 6ndin& seen in
which of the followin& conditions:
1. Fypo*elanosis of 1to
$. 8etterer"Siwe disease
%. /u#erous sclerosis
'. 7ackson Sertoli syndro*e
(. Fyper"1&+ syndro*e
A
(1 0ystrophic epider*olysis #ullosa is
associated with *utations in colla&en
?11. /rau*a or friction induced
#listerin& in these patients ha3e a
plane a splittin& in the:
1. Su#la*ina densa
$. Stratu* spinosu*
%. 8a*ina lucida
'. Stratu* #asale
(. Eone of these answers are
correct
A
($ A patient with *ultiple se#aceous
adeno*as should #e screened with
which of the followin& e<a*inations.
1. Hetinal e<a*ination
$. 8aryn&oscopy
%. Colonoscopy
'. MH1 of the spine
(. Henal ultrasound
C
(% A 1) year"old &irl presents with a
fa*ily history of 5ardner syndro*e.
Fer *other is 3ery concerned that her
dau&hter *ay ha3e the syndro*e as it
runs in her fa*ily and she has *any
skin co*plaints. ,hat is likelihood that
this &irl has 5ardner syndro*e #ased
on what you now a#out the inheritance
pattern and the fact that her father is
unaMected and her *other is a
hetero;y&ote for this condition.
1. (!N
$. $(N
%. 1!N
'. A(N
(. D!N
A
(' ,hich *ali&nancy is associated with
Cowden syndro*e.
1. Colon cancer
$. Henal cancer
%. 8un& cancer
'. 93arian cancer
(. Basal cell cancer
A
(( ,hich of the followin& disorders is
associated with delayed separation of
the u*#ilical cord.
1. 8eukocyte adhesion de6ciency
type 1 =8A0"1>
$. 1**unedysre&ulation:
polyendocrinopathy: enteropathy:
<"linked =1P+O>
%. Se3ere co*#ined
i**unode6ciency disorder=SC10>
'. O"linked a&a**a&lo#uline*ia
(. Myelopero<idase de6ciency
A
() ,hich of the followin& is true re&ardin&
tu#erous sclerosis.
1. Confetti"like *acules are
typically present at #irth
0
%)
$. 2acial an&io6#ro*as are the
*ost co**on cutaneous
*anifestation
%. Fypo*elanotic *acules =ash
leaf spots> ha3e a decreased
nu*#er of *elanocytes
'. Periun&ual 6#ro*as are
considered a *a4or feature in the
dia&nosis of tu#erous sclerosis
(. ) or *ore hypo*elanotic
*acules =ash leaf spots> are
considered a *a4or feature in the
dia&nosis of tu#erous sclerosis
(A Cutaneous osteo*as are seen in which
syndro*e.
1. ,aarden#ur& syndro*e
$. 8+9PAH0 syndro*e
%. Carney co*ple<
'. Al#ri&ht hereditary
osteodystrophy
(. 5aucherJs syndro*e
0
(C /he &ene P/+E =phosphatase and
tensin ho*olo& deleted on
chro*oso*e ten> is i*plicated in
which of the followin& syndro*es.
1. Cowden
$. Banayan"Hiley"Hu3alca#a
%. Proteus
'. All of the options are correct
(. Eone of the options are correct
0
(D A sporadic syndro*e aMectin&
transcriptional coacti3ator CH+B"
#indin& protein is:
1. Hu#instein"/ay#i syndro*e
$. Cornelia de 8an&e syndro*e
%. Eonne"Milroy disease
'. MaMucci syndro*e
(. Blue ru##er #le# ne3us
syndro*e
A
)! A dou#le row of eyelashes is
associated with:
1. 8y*phede*a"distichiasis
syndro*e
$. Cornelia de 8an&e syndro*e
%. Hu#instein"/ay#i syndro*e
'. Hussell"Sil3er syndro*e
(. Funters syndro*e
A
)1 Co**a shaped corneal opacities are
seen in what disease.
1. Hefsu* Syndro*e
$. S4o&ren"8arson Syndro*e
%. Pseudo<antho*a elasticu*
'. O"linked ichthyosis
(. Proteus syndro*e
0
)$ Oeroder*a pi&*entosu* =OP> 3ariant
is diMerent than classic OP in which of
the followin& way.
1. 0efecti3e 0EA nucleotide
e<cision repair of the &lo#al
&eno*e
$. 0efecti3e post"replication
repair
%. 1ncreased chro*oso*al
#reaka&e and sister chro*atid
e<chan&es
'. 0efecti3e 0EA nucleotide
e<cision repair of acti3ely
transcri#in& &enes
(. 8ow 1&M
B
)% A 1) *onth"old &irl presents with
patchy alopecia: whorled
1. Brain MH1
$. Alkaline phosphatase
0
%A
erythe*atous scaly eruption: and
asy**etric li*# shortenin&. ,hat
la#oratory or radiolo&ic test *ay aid in
dia&nosis.
%. Chest radio&raph
'. Bone 6l*s
(. Co*plete #lood count
)' ,hat is the inheritance pattern of
der*atosis with acantholysis.
1. Autoso*al do*inant
$. Autoso*al recessi3e
%. O"linked do*inant
'. O"linked recessi3e
(. Sporadic
A
)( A patient presents with focal
sy**etric pal*oplantar keratoder*a:
thickened: hyperkeratotic 6n&ernails
and toenails with a IpincerI
appearance and freLuent staph and
candida paronychial infections:
follicular hyperkeratosis of the knees
and el#ows and oral leukokeratosis.
/he patients *other and &randfather
#oth ha3e si*ilar skin 6ndin&s. ,hat is
the defect in PC type 1.
1. Keratin )a1)
$. Keratin )#1A
%. Keratin 11!
'. Keratin $e1!
(. Eone of these options are
correct
A
)) A $ year old &irl presents with sunken
eyes: lar&e ears: *icrocephaly and a
photodistri#uted eruption on her face.
+ye e<a* re3eals Jsalt and pepperJ
retina. /he &ene responsi#le for this
syndro*e codes for a:
1. /ranscription factor
$. Surface &lycoprotein
%. 8ysoso*al protease
'. 0EA helicase
(. Mis*atch repair &ene
0
)A 7unctional epider*olysis #ullosa with
pyloric atresia is associated with
*utations in:
1. /he alpha") su#unit of inte&rin
$. /he #eta"' su#unit of inte&rin
%. Both su#units of inte&rin can
ha3e *utations causin& this type of
4unctional epider*olysis #ullosa
'. Plectin
(. 8a*inin (
C
)C ,hich of the followin& is caused #y a
defect in a &ap 4unction protein.
1. +pider*olysis #ullosa si*ple<
$. Failey"hailey
%. +rythrokeratoder*a 3aria#ilis
'. 0yskeratosis con&enita
(. Bullous ichthyosis of sie*ens
C
)D ,hich of the followin& elastic tissue
diseases de*onstrates calci6ed elastic
6#ers.
1. Cutis la<a
$. Marfan syndro*e
%. Anetoder*a
'. Pseudo<antho*a elasticu*
(. Buschke"ollendorf syndro*e
0
A! Christ"Sie*ens"/ouraine Syndro*e is
*ost co**only linked with defects in
which of the followin& &enes.
1. E+M9
$. +ctodysplasin =+0A>
%. +HCC$
'. A/PAA
(. Eone of these options are
correct
B
A1 ,hich of the followin& conditions is
worsened #y in&estion of lithiu*.
1. 0arierJs 0isease
$. Failey"Failey 0isease
%. Fai*"Munk syndro*e
'. Fereditary ly*phede*a
=Eonne"Milroy disease>
(. +pider*olytic hyperkeratosis
A
%C
A$ 9n cutaneous e<a*: an&iokerato*a
corporis diMusu* is characteristic of
which of the followin& conditions.
1. Sialodosis
$. 2ucosidosis
%. 2a#ry disease
'. All of these options are correct
(. Eone of these options are
correct
0
A% ,hat is the inheritance pattern of
chronic &ranulo*atous disease.
1. Autoso*al recessi3e
$. Autoso*al do*inant
%. O"linked recessi3e
'. O"linked do*inant
(. Sporadic
C
A' Pre*ali&nant leukoplakia of the oral
*ucosa is associated with:
1. Bloo* syndro*e
$. ,erner Syndro*e
%. Oeroder*a Pi&*entosu*
'. 0yskeratosis Con&enita
(. Hoth*und"/ho*son syndro*e
0
A( +lectron *icroscopic e<a*ination of a
hair shaft re3eals a canal"like &roo3e
alon& the shaft of a trian&ular"shaped
hair. /his patient has:
1. Eetherton[s syndro*e
$. Menke[s Kinky Fair syndro*e
%. Spun"&lass hair
'. /richothiodystrophy
(. B4ornstad syndro*e
C
A) A *entally retarded patient is found to
also ha3e a *alar rash and downward
lens displace*ent. Another clinical
feature *i&ht include:
1. Fypertrichosis
$. Short stature
%. Multiple ne3i
'. Periodontitis
(. 0eep 3enous thro*#oses
+
AA ,hich of the followin& si&ns is not a
criteria for the dia&nosis of
Eeuro6#ro*atosis type 1.
1. Bilateral 3esti#ular
schwanno*as
$. A<illary frecklin&
%. 9ptic &lio*as
'. 5reater than ( cafJ"au"lait
*acules
(. Sphenoid dysplasia
A
AC /he de3elop*ent of which *ali&nancy
is *ost co**only associated with
ly*pho*atoid papulosis.
1. Eon"Fod&kinGs ly*pho*a
$. Mycosis fun&oides
%. Multiple *yelo*a
'. 1**uno#lastic ly*pho*a
(. ,aldenstro*Gs
*acro&lo#uline*ia
B
AD Cru*pled ears are associated with
which disorder.
1. +hlers"0anlos Syndro*e
$. Marfan syndro*e
%. Con&enital contractural
arachnodactyly
'. Cutis la<a
(. Buschke"9llendorf syndro*e
C
C! ,hich of the followin& is caused #y a
*utation in a &ene that leads to
defecti3e E2"KB acti3ation.
1. M+E 11a
$. Pie#aldis*
%. Chediak"Fi&ashi
'. ?ohwinkelJs
(. 1ncontinentia pi&*enti
+
C1 9donto&enic cysts and pal*oplantar
pits are seen in:
1. 5ardnerUVWs syndro*e
$. 5orlin Syndro*e
%. Bloo*UVWs Syndro*e
'. 5olt; Syndro*e
(. Hefsu* syndro*e
B
%D
C$ A '( year old wo*an with history of
uterine 6#roids presents with painful
6r* papules of the left upper ar*.
Biopsy of one of these lesions re3eals
s*ooth *uscle fascicles. She notes a
history of renal cell cancer in her
fa*ily. /he &ene i*plicated in this
syndro*e has which of the followin&
functions.
1. /elo*ere *aintenance
$. 1n3ol3ed in the Kre#Gs cycle
%. 1nhi#its */9H si&nallin&
'. 1*pairs folliculin function
(. +ncodes a deu#iLuitinatin&
en;y*e
B
C% ,hich *ali&nancy is seen in
appro<i*ately 1("$!N of people with
the disease characteri;ed #y a defect
in a parathyroid hor*one receptor
protein.
1. 9steosarco*a
$. An&iosarco*a
%. Chondrosarco*a
'. Hha#do*yosarco*a
(. +pitheliod sarco*a
C
C' A patient with pseudoherpetic keratitis
and a painful PPK would i*pro3e with
a diet low in:
1. /yrosinePhenylalanine
$. 5lycine
%. Cytosine
'. Biotin
(. Kinc
A
C( Colla&en 111 is *utated in which type=s>
of +hlers"0anlos syndro*e =+0S>.
1. All of the answers are correct
$. Eone of the answers are correct
%. Beni&n Fyper*o#ile =type 111>
'. ?ascular =type 1?>
(. Periodontitis =type ?111>
).
A
C) A child presents with preti#ial
hyperpi&*entation: ata<ia: decreased
*otor coordination: cirrhosis: and
decreased *otor coordination. /he
physical e<a* which would re3eal the
*ost speci6c 6ndin& for this disease is:
1. Fearin& test
$. Slit"la*p eye e<a*
%. +K5
'. Colonoscopy
(. Henal ultrasound
).
B
CA ,hich of the followin& diseases is
caused #y a *utation in a &ap 4unction
protein.
1. Striated PPK
$. Schopf"Schul;"Passar&e
syndro*e
%. Mal de Meleda
'. ?ohwinkel syndro*e =classic>
(. ?ohwinkel syndro*e
=ichthyotic>
).
0
CC /he followin& en;y*e defect is *ost
co**only seen in CF180 Syndro*e.
1. %"#eta"hydro<ysteroid
dehydro&enase
$. %"#eta"hydro<ysteroid
iso*erase
%. Aryl sulfatase +
'. EA0 o<ido reductase
(. 0EA helicase
).
A
CD +hlers"0anlos Syndro*e with
con&enital adrenal hyperplasia is
caused #y *utations aMectin& which of
the followin&.
1. 8ysyl hydro<ylase
$. Colla&en (
%. 2i#ronectin
'. 8ysyl o<idase
(. /enascin"O
).
+
D! A % year old #oy has white hair of the
central frontal scalp and depi&*ented
1. 1t is an autoso*al recessi3e
disorder of *elanocyte
B
'!
sy**etrical patches on the knees
since #irth. Eo ocular a#nor*alities or
deafness are noted. ,hat is true of
this disorder.
de3elop*ent
$. /here is typically no
pro&ression of depi&*ented
patches
%. He&ression of the white forelock
has #een noted
'. 9ne for* of this condition is
associated with iris pi&*entary
a#nor*alities
(. Hesults fro* a *utation in a
tu*or suppressor &ene
).
D1 Fereditary Fe*orrha&ic /elan&iectasia
syndro*e is trans*itted in an
autoso*al do*inant fashion and can
ha3e two 3ariants. /ype 1 is linked to
defects in FF/1: the endo&lin &ene.
/ype 11 is linked to defects in FF/$: the
A8K1 &ene. ,hat feature that
diMerentiates type 1 fro* type 11
clinically.
1. /ype 1 fa*ilies ha3e an increase
incidence of pul*onary
arterio3enous 6stulas
$. /ype 11 fa*ilies ha3e an
increased incidence of pul*onary
arterio3enous 6stulas
%. /ype 1 fa*ilies ha3e an
increased incidence of hepatic
arterio3enous *alfor*ations
'. /ype 11 fa*ilies ha3e a
decreased incidence of hepatic
arterio3enous *alfor*ations
(. Eone of the answers are correct
).
A
D$ A teena&e fe*ale presents with the
co*plaint of Inail fun&usI. 9n e<a*:
she has trian&ular lunulae:
pal*oplantar hyperhidrosis:
*icronychia and an a#sent patella.
,hich of the followin& &ene defects is
*ost likely in this patient.
1. 8MO1B
$. C98(A1
%. ++C1
'. 8KB1
(. E+M9
).
A
D% Heticulate pi&*entation of skin:
poikiloder*a: alopecia: nail atrophy:
pre*ali&nant oral leukoplakia: and a
2anconi"type pancytopenia resultin& in
early death in addition to posterior
fossa *alfor*ations is characteristic of
which of the followin& syndro*es.
1. 0yskeratosis con&enita
$. Foyeraal"Freidarsson syndro*e
%. Bloo* syndro*e
'. Cockayne syndro*e
(. ,iskott"Aldrich syndro*e
).
B
D' 2indin&s of dysplastic ne3i and
*elano*a inherited in an autoso*al
do*inant fashion is linked with which
of the followin&.
1. Breast *ali&nancy
$. /hyroid *ali&nancy
%. Pancreatic *ali&nancy
'. Henal cell carcino*a
(. Colon carcino*a
).
C
D( ,hich type of epider*olysis #ullosa is
associated with *itten defor*ities of
the hands.
1. 0o*inant dystrophic
$. Hecessi3e dystrophic
%. ,e#er"Cockayne
'. Ferlit; type
(. 5enerali;ed atrophic #eni&n
epider*olysis #ullosa =5AB+B>
).
B
D) Pre*ature a&in& seen in CockayneJs
syndro*e is caused #y a *utation in
1. /rans&luta*inase
$. A/M &ene
+
'1
which &ene. %. Patched &ene
'. E+M9 &ene
(. 0EA helicase &ene
).
DA 1n one 3ariant of epider*olysis #ullosa
si*ple<: those aMected ha3e *uscular
dystrophy in addition to the skin
6ndin&s. ,hich protein *utation has
#een linked to this 6ndin&.
1. Plako&lo#in
$. Plakophilin
%. Plectin
'. 0es*o&lein
(. 0es*ocollin
).
C
DC A patient with a port wine stain
co3erin& one enlar&ed le& likely has
which of the followin& associated
sy*pto*s.
1. 8y*phatic and deep 3enous
insuTciency
$. ?iscero*e&aly with
o*phalocele
%. Bilateral retinal
he*an&io#lasto*as
'. +nchondro*as
(. 0istichiasis
).
A
DD Patients with 0arierJs disease are at
increased risk for:
1. KaposiJs 3aricellifor* eruption
$. Melano*a
%. 0ecreased life span
'. Basal cell carcino*a
(. 8ipid a#nor*alities
).
A
1!
!
0efects in 2i#rillin $ are linked with: 1. Con&enital contractural
arachnodactyly
$. Cutis 8a<a
%. Arthrochalasis *ultiple<
con&enita
'. 9ccipital horn syndro*e
(. 8ipoid proteinosis
).
A
1!
1
/he #est screenin& test for
he*ochro*atosis is:
1. 2erritin
$. Fe*atocrit
%. Co*plete Blood Count
'. /ransferrin
(. Copper le3els
).
A
1!
$
A A year old #oy presents to your oTce
with short and sparse hair. Fe is also
short for his a&e. A hair *ount re3eals
alternatin& li&ht and dark #ands under
polari;ed li&ht. ,hich of the followin&
state*ents is correct re&ardin& this
condition.
1. +ye#rows and eyelashes are
not aMected
$. /here is no increased risk of
skin cancer
%. A*ino acid analysis of hair
re3eals hi&h sulfur content
'. /here is no increased hair
fra&ility.
(. 0ark #ands represent air
).
B
1!
%
,hich of the followin& conditions is
inherited in an O"linked do*inant =O0>
*anner.
1. Chodrodysplasia punctata
$. CF180 Syndro*e
%. 2ocal der*al hypoplasia
'. All of the answers are correct
(. Eone of the answers are correct
).
0
'$
1!
'
,hat *edication *ay e<acer#ate this
autoso*ally do*inant: acnatholytic
disorder.
1. Phenytoin
$. 8ithiu*
%. 9ral contracepti3es
'. Anti"*alarials
(. Corticosteroids
).
B
1!
(
Pruritus is S4o&ren 8arsson syndro*e is
attri#uted to accu*ulation of what
*olecule=s>.
1. Bile salts
$. Fista*ine
%. 8eukotriene
'. All of these answers are correct
(. Eone of these answers are
correct
).
C
1!
)
Menkes kinky hair syndro*e is
associated *ost co**only with which
of the followin& hair a#nor*alities.
1. Pili torti
$. /richorrhe<is nodosa
%. /richorrhe<is in3a&inata
'. Pili trian&ulati et canaliculati
(. Eone of these options are
correct
).
A
1!
A
/he presence of natal teeth and pincer
nails su&&ests which disease entity.
1. Con&enital syphillis
$. /halido*ide e<posure in utero
%. 1ncontinentia pi&*enti
'. Pachyonychia con&enita
(. Anhidrotic ectoder*al dysplasia
).
0
1!
C
Papillon"8efe3re and Fai*"Munk
syndro*es ha3e which of the followin&
sy*pto*s.
1. Hi&ht"3entricular
cardio*yopathy
$. Pseudoainhu*
%. +sopha&eal cancer
'. +ccrine syrin&o6#radeno*a
(. Periodontitis with tooth loss
).
+
1!
D
Painful crises and GwhorledG corneal
opacities are seen with which of the
followin& en;y*e a#nor*alities.
1. Fo*o&entisic acid o<idase
$. Alpha"&alactosidase A
%. 5lucocere#rosidase
'. 1duronate sulfatase
(. 5lucoronidase
).
B
11
!
8a*ellar ichthyosis is caused #y a
defect in trans&luta*inase 1. 1t can
present as a colloidion #a#y at #irth
with su#seLuent lar&e thick plates of
scale especially on -e<ures: ectropion
and ecla#iu*. 1f two unaMected carrier
parents ha3e a child: how likely is their
child to ha3e this condition.
1. $(N
$. A(N
%. 9nly *ale oMsprin& are
aMected
'. 9nly fe*ale oMsprin& are
aMected
(. Eone of these answers are
correct
).
A
11
1
+pista<is in early childhood to teens
followed #y *ultiple cutaneous and
&astrointestinal telan&ectasias
descri#es which of the followin&
syndro*es.
1. Fereditary Fe*orrha&ic
/elan&iectasia syndro*e
$. MaMucci syndro*e
%. CH+S/ syndro*e
'. Ata<ia telan&ectasia
(. 2a#ry disease
).
A
'%
11
$
A thirty"year"old wo*an presents with
new pro&ressi3ely worsenin&
headaches. Bpon e<a*: you notice
*ultiple acral keratotic papules and
papillo*as of the ton&ue. ,hat
*ali&nancy does this patient need to
#e screened for.
1. colon cancer
$. o3arian cancer
%. #reast cancer
'. #asal cell carcino*a
(. *elano*a
).
C
11
%
,hat nail chan&e is seen in patients
with Mal de Meleda Syndro*e.
1. 9nycholysis
$. 8on&itudinal rid&in&
%. Koilonychia
'. leukonychia
(. ptery&iu*
).
C
11
'
,hich of the followin& is caused #y a
defect in keratins ' @ 1%.
1. ,hite spon&e ne3us
$. +pider*olysis #ullosa si*ple<
%. +pider*olysis #ullosa si*ple<
with *yotonic dystrophy
'. 7unctional +B with pyloric
atresia
(. Clouston[s syndro*e
).
A
11
(
/he syndro*e characteri;ed #y
&enerali;ed *ild hyperkeratosis:
erythe*atous keratotic plaLues:
pal*oplantar keratoder*a: non"
pro&ressi3e sensorineural deafness:
pro&ressi3e #ilateral keratitis with
secondary #lindness is:
1. K10 syndro*e
$. ?ohwinkel syndro*e
%. +rythrokeratoder*a 3aria#ilis
'. CF180 syndro*e
(. Hefsu* syndro*e
).
A
11
)
,hich of the followin& is caused #y a
defect in lysoso*al transport:
1. oculocutaneous al#inis* 1
$. oculocutaneous al#inis* 11
%. Pie#aldis*
'. Chediak"hi&ashi
(. Bloo*Js syndro*e
).
0
11
A
/he *ost co**on ocular association
with cutis *ar*orata telan&iectatica
con&enital is:
1. Cataracts
$. 5lauco*a
%. Hetino#lasto*a
'. Corneal opacity
(. An&ioid streaks
).
B
11
C
Painful crises and GwhorledG corneal
opacities are seen with which of the
followin& en;y*e a#nor*alities.
1. Fo*o&entisic acid o<idase
$. Alpha"&alactosidase A
%. 5lucocere#rosidase
'. 1duronate sulfatase
(. 5lucoronidase
).
B
11
D
,hich of the followin& *edications is a
terato&en associated with a aplasia
cutis con&enita.
1. Propranolol
$. Methi*a;ole
%. 8ithiu*
'. Alcohol
(. ,arfarin
).
B
1$
!
,hat cutaneous *anifestation is
associated with fa*ilial cere#ral
ca3erno*as.
1. ?errucous he*an&io*s
$. 5lo*eruloid he*an&io*as
%. hyperkeratotic cutaneous
C
''
capillary"3enous
*alfor*ations=FCC?M>
'. se&*ental facial he*an&io*as
(. /ufted an&io*as
).
1$
1
13ory"colored papules #etween the
an&les of the scapulae are
characteristic of which syndro*e:
1. Furler
$. Scheie
%. MorLuio
'. Funter
(. San6lippo
).
0
1$
$
,hat is the characteristic radio&raphic
6ndin& in type 1 5aucher disease.
1. +nchondro*as
$. 9steopoikilosis
%. Melorheostosis
'. +hrlen*eyer -ask defor*ity
(. Supernu*erary 3erte#rae with
e<tra ri#s
).
0
1$
%
A patient with Klinefelter Syndro*e
*ay #e e<pected to e<perience which
of the followin&:
1. Hecurrent pul*onary infections
$. Hecurrent le& ulcers
%. Pul*onary 3al3e stenosis
'. 5astroesopha&eal re-u<
(. Scarrin& alopecia
).
B
1$
'
0er*ato6#rosis lenticularis
disse*inata and osteopoikilosis are
6ndin&s seen with *utations of which
of the followin& &enes.
1. 8+M0%
$. 2i#rillin $
%. ABCC)
'. 8ysyl hydro<ylase
(. 8ysyl o<idase
).
A
1$
(
/he E+M9 &ene is defecti3e in Bloch"
Sul;#er&er syndro*e. ,hat other
syndro*e has #een linked with defects
in the E+M9 &ene.
1. Fypohidrotic ectoder*al
dysplasia with i**une de6ciency
$. Fypo*elanosis of 1to
%. /u#erous sclerosis
'. ,aarden#ur& syndro*e
(. Pie#aldis*
).
A
1$
)
,hich of the followin& su#types of
+hlers"0anlos Syndro*e =+0S> is
associated with early de*ise.
1. /ype 1 =5ra3is>
$. /ype ' =?ascular>
%. /ype ( =O"linked>
'. /ype A =Arthrochalasis *ultiple<
con&enita>
(. /ype 1! =2i#ronectin>
).
B
1$
A
A patient presents with se3eral li&ht
#lue cyst"like lesions on the eyelid.
/hey consult their list of pro#le*s and
#rin& up plantar hyperkeratosis and
dysplastic toenails. 9n oral e<a*: you
note that they ha3e #oth upper and
lower dentures. /he patient relates
that after losin& their I#a#y teethI:
only % teeth &rew in their place. ,hat
syndro*e does this person *ost likely
ha3e.
1. Schopf"Schul;"Passar&e
$. 5ardner syndro*e
%. Fypohidrotic ectoder*al
dysplasia
'. Cowden syndro*e
(. Cronkhite"Canada
).
A
'(
1$
C
8a*ellar ichthyosis is caused #y
*utations in which of the followin&
&enes.
1. Steroid sulfatase
$. 2atty aldehyde o<idoreductase
%. Phytanoyl coen;y*e A
hydro<ylase de6ciency
'. Arylsulfatase +
(. /rans&luta*inase
).
+
1$
D
,hich of the followin& pairs of
diseases are caused #y *utations in
0EA helicases.
1. Bloo* syndro*e and
Hoth*und"/ho*pson syndro*e
$. Oeroder*a pi&*entosu* and
Cockayne syndro*e
%. Muir"/orre syndro*e and Birt"
Fo&&"0u#e syndro*e
'. 0yskeratosis con&enita and
Peut;"7e&hers syndro*e
(. Cowden syndro*e and
Bannayan"Hiley"Hu3alca#a
syndro*e
).
A
1%
!
,hat is the &ene defect in this
condition: which is also called Mendes
da Costa syndro*e.
1. Keratin 1 and 1!
$. SP1EK(
%. S8BHP"1
'. Conne<in $)
(. Conne<in %1
).
+
1%
1
A patient with *ultiple deeply
pi&*ented papules has a skin #iopsy
which re3eals an epitheloid #lue
ne3us. /he ne<t appropriate step is:
1. Heassure the patient and follow
up as needed
$. Schedule prophylactic e<cision
of the lesion
%. Be&in a *ali&nancy work"up
'. Hefer to &enetics
(. 9rder an echocardio&ra*
).
+
1%
$
,hat condition is associated with this
6ndin& of in-a**atory keratotic facial
papules which *ay result in scarrin&
and atrophy.
1. Chloracne
$. Syste*ic lupus erythe*atosus
%. Keratosis pilaris
'. HeiterGs syndro*e
(. Blerythe*a ophryo&enes
).
+
1%
%
,hich of the followin& is caused #y a
defect in cathepsin C.
1. Hu#enstein"/ay#i
$. Bullous 1cthyosis of Sie*ens
%. Muir"/orre
'. Papillon"8efe3re
(. Eail"Patella syndro*e
).
0
1%
'
Mutations aMectin& the ?+52 receptor"
% cause which of the followin&
disorders.
1. Fereditary ly*phede*a
=Eonne"Milroy disease>
$. 8y*phede*a"distichiasis
syndro*e
%. 8y*phede*a and ptosis
'. Eoonan syndro*e
(. Fereditary he*orrha&ic
telan&iectasias
).
A
1% A ( *onth old &irl presents with failure 1. 8einer syndro*e C
')
( to thri3e. She has had life"lon& atopic
der*atitis treated with topical
hydrocortisone crea* and has
persisent hypernatre*ia. 9n your
e<a*: she has &enerali;ed erythe*a
and scalin& of her #ody and
trichorrhe<is in3a&inata on
e<a*ination of hairs fro* her
eye#rows. ,hich syndro*e is she
*ost likely to ha3e.
$. 9*enn Syndro*e
%. Eetherton Syndro*e
'. ,iskott"Aldrich Syndro*e
(. Se3ere atopic der*atitis
).
1%
)
,hich of the followin& are cutaneous
features of Marfan syndro*e.
1. 8oose skin and cru*pled ears
$. 0er*ato6#rosis lenticularis and
striae
%. 2at herniation and cutaneous
atrophy
'. Scleroder*oid chan&es and
dyspi&*entation
(. Striae and elastosis perforans
serpi&inosa
).
+
1%
A
Eon"#ullous icthyosifor* erythroder*a
is caused #y which of the followin&
*utations:
1. /rans&luta*inase"1 &ene
=/5M1>
$. 1$H"lipo<y&enase &ene
=A89O1$B>
%. 8ipo<y&enase"% &ene =A89O+%>
'. Both 1$H"lipo<y&enase &ene
=A89O1$B> and lipo<y&enase"%
&ene =A89O+%> are correct
(. All of these answers are correct
).
+
1%
C
1n patients with diMuse con&enital
he*an&io*atosis: the *ost co**on
site for e<tracutaneous in3ol3e*ent is
the :
1. 8i3er
$. /hyroid
%. 8un&s
'. Colon
(. Brain
).
A
1%
D
,hich syndro*e is characteri;ed #y
hyperhidrosis: lack of pain sensation:
hypersali3ation: and a#sent fun&ifor*
papillae.
1. /urner Syndro*e
$. Eoonan Syndro*e
%. Hiley"0ay
'. Hu#instein"/ay#i syndro*e
(. Cornelia de lan&e Syndro*e
).
C
1'
!
+rythe*atous keratotic plaLues of K10
Syndro*e *ost co**only occur in
which location.
1. 2ace
$. Eeck
%. Chest
'. Back
(. A#do*en
).
A
1'
1
,hich syndro*e is characteri;ed #y
#road thu*#s: a lar&e #eaked nose:
and capillary *alfor*ation.
1. Klinefelter
$. Proteus syndro*e
%. Bloo* syndro*e
'. Hu#instein"/ay#i
(. +hlers"0anlos syndro*e
).
0
1' A (! year *an presents with 1. Copper le3els C
'A
$ &enerali;ed *etallic"&rey
hyperpi&*entation. Fis past *edical
history includes dia#etes:
hepato*e&aly and arryth*ias.
8a#oratory tests should include:
$. 8ead le3els
%. 1ron le3els
'. Arsenic le3els
(. Cyanide le3els
).
1'
%
Patients with he*ochro*atosis are at
increased risk for which of the
followin&.
1. ?i#rio 3ulni6cus infections
$. Sersenia infections
%. Polyarthritis
'. 5enerali;ed *etallic"&rey
hyperpi&*entation
(. All of these options are correct
).
+
1'
'
A child presentin& with the scalp
6ndin&s shown and a ri&ht ar*
hypoplasia would #e dia&nosed with
which of the followin& syndro*es.
1. Ada*s"9li3er syndro*e
$. BartGs syndro*e
%. Pro&eria
'. 0unni&an syndro*e
(. Eone of these options are
correct
).
A
1'
(
2a*ilial *acular and lichen
a*yloidosis is a feature of which of the
followin& conditions.
1. Sipple syndro*e
$. Peut;"7e&hers syndro*e
%. Marfan syndro*e
'. 0yskeratosis con&enita
(. Birt"Fo&&"0u#e syndro*e
).
A
1'
)
IMousyI odor of urine is characteristic
of which of the followin& syndro*es.
1. Phenylketonuria
$. Funter disease
%. Alkaptonuria
'. Maple Syrup Brine disease
(. Furler disease
).
A
1'
A
,hich of the followin& la#oratory test
*i&ht pro3e useful in the dia&nosis of
2a#ry disease:
1. Co*plete #lood count with
diMerential
$. 2astin& lipids
%. Brinary sedi*ent e<a* with
polari;in& li&ht *icroscopy
'. Stool &uaiac
(. Bleedin& ti*e
).
C
1'
C
,hat is the *ode of trans*ission for
la*ellar ichthyosis.
1. Autoso*al do*inant
$. Autoso*al recessi3e
%. O"linked do*inant
'. O"linked recessi3e
(. Sporadic
).
B
1'
D
,hich of the followin& is E9/ a
co*plication of Kasa#ach"Merritt
Syndro*e:
1. /hro*#ocytopenia
$. CF2
%. Ata<ia
'. 0isse*inated intra3ascular
coa&ulation
(. 5astrointestinal #leedin&
).
C
1(
!
A se3en *onth old infant dia&nosed
with ec;e*a on her face returns for a
diaper"rash follow"up. A one"*onth
1. Stool sa*ples
$. 2ontanelle e<a*ination
%. +<a*ination of pal*s and soles
C
'C
trial of topical antifun&als has failed to
i*pro3e the infantJs syste*s. /he
part of the physical e<a* that *i&ht
pro3e *ost useful include:
'. Palpation of a#do*en
(. Fearin& test
).
1(
1
+pider*al ne3us syndro*es
inheritance pattern is:
1. Sporadic
$. O"linked recessi3e
%. O"linked do*inant
'. Autoso*al recessi3e
(. Autoso*al do*inant
).
A
1(
$
,hich disease is found *ore
co**only in *others of patients with
chronic &ranulo*atous disease.
1. Sarcoidosis
$. +rythe*a nodosu*
%. Chur&"Straus disease
'. ,e&enerGs disease
(. 0iscoid lupus erythe*atous
).
+
1(
%
Pseudo<antho*a elasticu* is caused
#y *utations in which of the followin&
&enes.
1. 2i#rillin 1
$. +lastin &ene
%. 8ysyl o<idase
'. ABCC) &ene
(. Colla&en (
).
0
1(
'
2indin&s of eyelid papules =strin& of
pearls> and a hoarse cry in infants is
characteristic of which of the followin&
syndro*es.
1. 8ipoid proteinosis
$. A*yloidosis
%. Pseudo<antho*a elasticu*
'. 0isse*inated <antho*as
(. Eone of these answers are
correct
).
A
1(
(
Mutations in calciu* transporters
cause which pair of diseases.
1. +rythrokeratoder*ia 3aria#ilis
and pro&ressi3e sy**etric
erythrokeratoder*ia
$. 8a*ellar ichthyosis and
non#ullous con&enital ichthyosifor*
erythroder*a
%. Hefsu* syndro*e and S4o&ren"
8arsson syndro*e
'. Chondrodysplasia punctata and
CF180 syndro*e
(. 0arierJs disease and Failey"
Failey disease
).
+
1(
)
,hich of the followin& is not classically
associated with pheochro*octyo*a.
1. Multiple +ndocrine Eeoplasia
/ype 11A
$. Multiple +ndocrine Eeoplasia
/ype 11B
%. ?on"Fippel"8indau Syndro*e
'. Co## Syndro*e
(. Eeuro6#ro*atosis
).
0
1(
A
Patients with <"linked icthyosis are
*ore prone to &ettin& which two
*ali&nancies.
1. Pancreatic and acute
ly*phocytic leuke*ia =A88>
$. Pancreatic and acute
*yelo&enous leuke*ia =AM8>
%. /esticular and AM8
0
'D
'. /esticular and A88
(. Henal cell and A88
).
1(
C
Fypere<tesi#le skin: &apin& wounds:
ci&arette"paper scars: *olluscoid
pseudotu*ors: and calci6ed
su#cutaneous nodules are
characteristic of which syndro*e.
1. Marfan syndro*e
$. Con&enital contractural
arachnodactyly
%. +hlers"0anlos Syndro*e
'. Cutis la<a
(. Pseudo<antho*a elasticu*
).
C
1(
D
,hich 6ndin& would you e<pect in a
child with dyskeratosis con&enita.
1. 1ncreased risk for pancreatic
cancers
$. 9ral leukoplakia
%. Firsutis*
'. Eor*al he*atolo&ic status
(. Eor*al nails
).
B
1)
!
,hat is this syndro*e which is
histolo&ically characteri;ed #y widely
dispersed &ranular *aterial a*idst
nor*al 6#ers.
1. +hlers 0anlos Syndro*e
$. Pseudo<antho*a +lasticu*
%. Buschke"9llendorf Syndro*e
'. 2ocal 0er*al Fypoplasia
(. 8ipoid Proteinosis
).
B
1)
1
Beare"Ste3enson cutis &yrata
syndro*e is linked with *utations in:
1. 2i#ro#last &rowth factor
receptor $
$. BSC8$
%. 8MEA
'. A/PAA
(. Eone of these answers are
correct
).
A
1)
$
1n a patient suspected of ha3in&
*ultiple endocrine neoplasia type 11#:
which la# test would #e appropriate.
1. Calcitonin
$. 5luca&on
%. Parathyroid hor*one
'. Calciu*
(. Cortisol
).
A
1)
%
Pseudo<antho*a elasticu* =PO+> can
#e trans*itted in an autoso*al
do*inant: recessi3e or sporadic
*anner. ,hich of the followin& &enes
is *utated in PO+.
1. ABCC)
$. MAE1
%. Colla&en 111
'. Colla&en ?
(. Colla&en 1
).
A
1)
'
A patient with this autoso*al recessi3e
disorder caused #y a defect in helicase
is an increased risk for which
*ali&nancy.
1. Acute leuke*ia
$. Henal cell carcino*a
%. Medullary thyroid carcino*a
'. SLua*ous cell carcino*a of the
lun&
(. Prostate carcino*a
).
A
1)
(
,hat 6ndin& is seen on #rain i*a&in&
of patients with Papillon"8efe3re
Syndro*e.
1. /ra* track calci6cations
$. Calci6cation of the fal< cere#ri
%. Calci6cation of the
hippoca*pus
'. Calci6cation of the dura
0
(!
(. A&enesis of the corpus
callosu*
).
1)
)
,hich of the followin& syndro*es is
characteri;ed #y follicular
atrophoder*a: hypohidrosis:
hypotrichosis and *ultiple #asal cell
carcino*as.
1. Ba;e< syndro*e
$. Ho*#o syndro*e
%. Has*usen syndro*e
'. 5orlin syndro*e
(. 1ncontinentia Pi&*enti
).
A
1)
A
An infant presents with *ultiple
con&enital he*an&o*as in an
&enerali;ed distri#ution. ,hat is the
*ost serious associated condition.
1. Con&esti3e Feart 2ailure
$. 9#structi3e 4aundice
%. Portal hypertension
'. All of the answers are correct
(. Eone of the answers are correct
).
A
1)
C
A trian&ular"shaped lunula is a
characteristic 6ndin& in which disease.
1. 0arierGs disease
$. 0yskeratosis con&enita
%. +pider*al ne3us syndro*e
'. 1ncontinentia pi&*enti
(. Eail"patella syndro*e
).
+
1)
D
1n ata<ia telan&ectasia: the A/M &ene
is *utated. /he product of the A/M
&ene is an en;y*e which:
1. Hesponds to 0EA da*a&e #y
phosphorylatin& key 0EA repair
su#strates
$. Binds transfor*in& &rowth
factor #eta protein
%. 1s the ?+52 receptor %
'. Participates in E2"kB acti3ation
(. 1s an inhi#itor of 51 cyclinCdk
co*ple<es
).
A
1A
!
A 1) year"old &irl presents with a
fa*ily history of 5ardner syndro*e.
Fer *other is 3ery concerned that her
dau&hter *ay ha3e the syndro*e as it
runs in her fa*ily and she has *any
skin co*plaints. 5ardner syndro*e
has #een linked to defects in #eta"
catenin *ediated transcription. ,hich
of the followin& &enes dysfunction is
responsi#le.
1. APC
$. S/K11
%. CS80
'. P/CF
(. ABCC)
).
A
1A
1
Fypoplasia of the #reast can #e seen
in which disease.
1. Anhidrotic ectoder*al dysplasia
$. MaMucci syndro*e
%. Con&enital syphilis
'. Marfan syndro*e
(. 9steo&enesis i*perfecta
).
A
1A
$
,hich of the followin& syndro*es are
linked to a P/+E &ene *utation.
1. Banayan"Konana
$. Proteus
%. Cowden
'. All of these options are correct
(. 8her*itte"0uclos disease
).
0
1A
%
/he *ost co**on neoplas* seen in
MaMucci Syndro*e is:
1. +nchondro*as
$. An&iosarco*as
A
(1
%. 9steosarco*as
'. 8y*phan&iosarco*as
(. chondrosarco*a
).
1A
'
,hat is the *ost co**on &enetic
defect associated with this syndro*e.
1. Eeuro6#ro*in
$. Merlin
%. /u#erin
'. Fa*artin
(. 2olliculin
).
A
1A
(
A patient with thyroid carcino*a and
co##lestone"like chan&es of the oral
*ucosa will also likely ha3e:
1. /richoepithelio*as
$. 2i#rofolliculo*as
%. /richole**o*as
'. Cylindro*as
(. Syrin&o*as
).
C
1A
)
,hat is the underlyin& &ene defect for
this trans&rediens for* of
pal*oplanter keratoder*a
1. S8BHP"1
$. /9C &ene
%. Plako&lo#in
'. Keratin type 1
(. Keratin type D
).
A
1A
A
,hich of the followin& is E9/ part of
the Carney co*ple<.
1. Pe& or conical teeth
$. Cardiac: cutaneous or
*a**ary *y<o*as
%. Pi&*ented skin lesions
'. +ndocrine a#nor*alities
(. Pri*ary pi&*ented nodular
adrenocortical disease
).
A
1A
C
5iant lysoso*al &ranules are seen in
which disease.
1. Chediak"Fi&ashi syndro*e
$. 5riscelli syndro*e
%. Pie#aldis*
'. 1ncontinentia pi&*enti
(. Carney co*ple<
).
A
1A
D
9steopathia striata is seen in which of
the followin& disorders.
1. 5aucherJs disease
$. Al#ri&htJs syndro*e
%. Aplasia cutis con&enita
'. 2ocal der*al hypoplasia
(. Scleroder*a
).
0
1C
!
Medullo#lasto*a is seen in which
syndro*e.
1. 5ardnerJs syndro*e
$. Multiple endocrine neoplasia $#
%. Muir"/orre syndro*e
'. Basal cell ne3us syndro*e
(. Eeuro6#ro*atosis /ype 1
).
0
1C
1
/he *ost co**on cardio3ascular
defect in patients with Eoonan
syndro*e is:
1. Atrial septal defect
$. ?entricular septal defect
%. +nlar&ed aorta
'. Pul*onic 3al3e stenosis
(. Aortic stenosis
).
0
1C 0er*ato6#rosis lenticularis 1. +hlers"0anlos syndro*e +
($
$ disse*inata is seen in which of the
followin& conditions.
$. Marfan syndro*e
%. Pseudo<antho*a elasticu*
'. 2ocal der*al hypoplasia
(. Buschke"9llendorf syndro*e
).
1C
%
A %$ year"old wo*an is ( weeks
pre&nant and is dia&nosed with
hyperthyroidis*. Fer doctor &i3es her
a prescription for on *ethi*a;ole 1!
*& P9 tid. ,hich of the followin& fetal
a#nor*alities could #e caused #y this
e<posure.
1. Aplasia cutis con&enita
$. Menin&ocele
%. +ncephalocele
'. Spina #i6da
(. 0er*oid cyst
).
A
1C
'
A patient has recurrent infections and
is found to ha3e a disorder of
pha&ocytic cells fro* an ina#ility of
pha&ocytes to under&o the respiratory
#urst needed to kill certain types of
#acteria and fun&i. Carriers of this
disease are also at risk for which
condition.
1. Breast cancer
$. ?itili&o
%. 0iscoid lupus
'. /hyroid disease
(. Cataracts
).
C
1C
(
,hich of the followin& is correct a#out
ne3oid #asal cell carcino*a syndro*e.
1. known as 5ardner syndro*e
$. autoso*al recessi3e
%. *ultiple keratoacantho*as
'. calici6cation of the fal<
(. odonto&enic steato*as
).
0
1C
)
Sou recei3e a hospital consult fro* the
&astroenterolo&y ser3ice for a '$"year
old wo*an with esopha&eal cancer.
/hey would like your opinion on the
yellow: thickened areas on her pal*s
and soles in areas of pressure. ,hen
you speak with her: she says that her
father had si*ilar pro#le*s and it runs
in her fa*ily. ,hich of the followin& is
defecti3e.
1. /9C &ene
$. 0es*oplakin
%. Plako&lo#in
'. Conne<in %!.%
(. Conne<in %1
).
A
1C
A
A '"year old #oy presents with
&enerali;ed white scale. /he *other
reports that her son was #orn with a
ti&ht *e*#rane en3elopin& his #ody.
Peripheral #lood s*ear is within
nor*al li*its. ,hat is the *ost likely
dia&nosis.
1. Con&enital ichthyosifor*
erythroder*a
$. Eeutral lipid stora&e disease
%. 8a*ellar ichthyosis
'. Eetherton syndro*e
(. 1chthyosis 3ul&aris
).
A
1C
C
Patients with 4unctional epider*olysis
#ullosa ha3e #een found to ha3e
*utations in:
1. 8a*inin (
$. Bullous pe*phi&oid anti&en $
%. Colla&en 1A
'. BP1C!
(. All of the answers are correct
).
+
1C
D
Keratins 1 and 1! are i*portant
inter*ediate 6la*ents in supra#asal
keratinocytes. 5enetic *utation of
these keratins can lead to which of the
followin& disorders.
1. Eetherton syndro*e
$. S4o&ren"8arsson syndro*e
%. Pachyonychia con&enita type 1
'. +pider*olytic hyperkeratosis
Bullous ichthyosifor* erythroder*a
(. ,hite spon&e ne3us
0
(%
).
1D
!
,hich syndro*e is due to a defecti3e
secreted *a**ilian 8y)uPAH"related
protein"1.
1. EethertonGs syndro*e
$. Hefsu*Gs syndro*e
%. S4o&ren"8arsson syndro*e
'. Mal de Meleda syndro*e
(. Fai*"Munk syndro*e
).
0
1D
1
/he co*#ination of painful
pal*oplantar keratoder*a and
pseudoherpetic keratitis is
characteristic of which of the followin&
syndro*es.
1. Ea<os syndro*e
$. ?ohwinkel syndro*e
%. Hichner"Fanhart syndro*e
'. Fowel"+3ans syndro*e
(. Schopf"Schul;"Passar&e
syndro*e
).
C
1D
$
A de6ciency in sialophorin: a surface
&lycoprotein: is thou&ht to play a role
in which &enetic disorder.
1. ,iskott"aldrich syndro*e
$. Chediak"hi&ashi syndro*e
%. ,erner syndro*e
'. Bloo* Syndro*e
(. Cornelia de 8an&e syndro*e
).
A
1D
%
,hich of the followin& is defecti3e in
+hlers"0anlos syndro*e =+0S> with
con&enital adrenal hyperplasia.
1. /enascin"O
$. 8ysyl o<idase
%. 8ysyl hydro<ylase
'. Eone of these answers are
correct
(. All of these answers are correct
).
A
1D
'
,hat protein is de6cient in the
condition shown.
1. Calciu* A/PJase 11C1
$. Calciu* A/PJase 11A$
%. P+O"A
'. SP1EK(
(. 0es*o&lein %
).
A
1D
(
JCoast of MaineJ cafJ au lait
*acules are characteristic of which
condition
1. Fypo*elanosis of 1to
$. Carney co*ple<
%. McCune"Al#ri&ht syndro*e
'. 5aucherJs syndro*e
(. /u#erous sclerosis
).
C
1D
)
0yshcro*atosis sy**etrica
hereditaria =0SF> is a disorder
characteri;ed #y asy*pto*atic hypo"
and hyperpi&*ented *acules on the
face and dorsal e<tre*ities. Mutations
in which of the followin& &enes is
associated with this condition.
1. 0KC
$. P/+E
%. A0AH1
'. +HCC'
(. S/K11
).
C
1D
A
Bilateral o3arian cystadeno*as and
parotid *ono*orphic adeno*as are
seen in which of the followin&
conditions.
1. Cowden syndro*e
$. Proteus syndro*e
%. ?on"Fippel"8indau syndro*e
'. Eoonan syndro*e
(. Beckwith",ieder*an syndro*e
).
B
1D
C
,hich of the followin& is E9/ a
characteristic skin 6ndin& in patients
with 0own Syndro*e.
1. Syrin&o*as
$. +lastosis perforans serpi&inosa
%. Sin&le pal*ar crease
+
('
'. 2lat nipples
(. S*all ton&ue
).
1D
D
/his for* of +B si*ple< has a defect in
actin asse*#ly: not keratin for*ation.
1. 0owlin& Meara
$. ,e#er"Cockayne
%. Koe#ner
'. Kindler
(. 9&na
).
0
$!
!
Mutations in nuclear la*ins are
associated with which clinical feature.
1. 8ipo*atosis
$. Sarco*as
%. 8y*phede*a
'. Aplasia cutis con&enita
(. 8ipodystrophy
).
+
$!
1
Brticaria pi&*entosa is linked to a
defect in the c"kit protoonco&ene.
,hat autoso*al do*inant skin disease
also has #een linked to this defect.
1. Pie#aldis*
$. Fypo*elanosis of 1to
%. ,aarden#ur& syndro*e
'. Fer*ansky"Pudlak syndro*e
(. 1ncontinentia pi&*enti
).
A
$!
$
A ' year"old #oy presents with $ soft:
dark"#lue: co*pressi#le nodules on his
e<tre*ities. Fis *other has noted that
these lesions ha3e increased sweatin&
and that they were present at #irth. Eo
one else in the fa*ily has had si*ilar
skin lesions. ,hat step is indicated
6rst to help deter*ine the dia&nosis.
1. Stool &uiac
$. MH1 of the a#do*en
%. CBC
'. 1**ediate referral to a
&astroenterolo&ist
(. Biopsy of a skin lesion
).
A
$!
%
A BSC8$ &ene *utation with the
cutaneous 6ndin&s of &enerali;ed
lipodystrophy: hyperlipe*ia:
hepato*e&aly: acanthosis ni&ricans:
ele3ated #asal *eta#olic rate and non"
ketotic insulin resistant dia#etes
*ellitus are characteristic of which of
the followin& syndro*es.
1. Berardinelli"Seip con&enital
lipodystrophy
$. 2a*ilial partial lipodystrophy
%. B4ornstad syndro*e
'. All of the answers are correct
(. Eone of the answers are correct
).
A
$!
'
/he treat*ent for acroder*atitis
enteropathica is:
1. Kinc supple*entation
$. 1ron supple*entation
%. ?ita*in B1 supple*entation
'. ?ita*in B1$ supple*entation
(. Phle#oto*y
).
A
$!
(
+ctopia lentis =downward displace*ent
of the lens> is characteristic of:
1. Marfan syndro*e
$. Fo*ocystinuria
%. Phenylketonuria
'. Multiple Car#o<ylase de6ciency
(. +hlers"0anlos syndro*e
).
B
$!
)
A Puerto Hican wo*an is seen in clinic
for a pruritic rash on her trunk. A
punch #iopsy is perfor*ed. /he #iopsy
site continues to #leed: with
he*ato*a for*ation. /he #leedin& is
e3entually controlled. 9n further
1. Fer platelets lack dense #odies:
causin& e<cess #leedin&
$. Fer intrinsic factor is de6cient
%. Fer 2actor ?111 le3els are low
'. She is con&entially de6cient in
platelets
A
((
e<a*: her skin and hair are li&ht
#rown. She has a history of
&ranulo*atous colitis. ,hat it the
*ost likely reason she had e<cess
#leedin& with a si*ple procedure.
(. Eone of the answers are correct
).
$!
A
,hich of the followin& syndro*es
de*onstrate atrophoder*a
3er*iculatu*.
1. /u;un Syndro*e
$. H9MB9 Syndro*e
%. Eicolau"Balus Syndro*e
'. Braun"2alco"Mar&hescu
Syndro*e
(. All of these answers are correct
).
+
$!
C
/he arylsulfatase C &ene is *utated in
which disease.
1. O"linked ichthyosis
$. Hefsu* syndro*e
%. Fai*"Munk syndro*e
'. Ea<os syndro*e
(. 5riscelli syndro*e
).
A
$!
D
Mucosal *ali&nancy is a co*plication
of:
1. 9ral hairy leukoplakia
$. ,hite spon&e ne3us
%. 0yskeratosis con&enital
'. Chronic candidiasis
(. 2ocal epithelial hyperplasia
).
C
$1
!
2ocal 0er*al Fypoplasia =5olt;
Syndro*e> can diMerentiated fro*
1ncontinentia Pi&*enti #y
1. /ype of inheritance
$. Presence of 8inear lesions alon&
the lines of Blaschko
%. Presence of #listerin& lesions
'. Fair and teeth a#nor*ality
(. +ye and CES a#nor*ality
).
C
$1
1
,hich &ene is defecti3e in ,iskott"
Aldrich syndro*e.
1. ,AS
$. CSBA
%. CSBB
'. EC21
(. EC2$
).
A
$1
$
,hich 3ascular disorder is
characteri;ed #y facial 3ascular
*alfor*ation and ipsilateral
intracranial and retinal arterio3enous
*alfor*ations=A?Ms>.
1. Stur&e",e#er syndo*e
$. PFAC+S
%. +ncephalotri&e*inal
an&io*atosis
'. Bonnet 0echaune Blanc
syndro*e
(. ?on 8ohui;enJs disease
).
0
$1
%
,hat condition is associated with a
*utation in COCH'.
1. Ata<ia telan&iectasia
$. 8eukocyte adhesion de6ciency
%. Chronic &ranulo*atous disease
'. SC10
(. ,F1M syndro*e
).
+
$1
'
,hich of the followin& is caused #y a
*utation in a &ene which codes for
steroid sulfatase.
1. 2a#ry disease
$. 8esch"nyhan disease
%. O"linked ichthyosis
'. 8a*ellar icthyosis
C
()
(. Chediak"Fi&ashi
).
$1
(
,hich optha*olo&ic disease is
associated with this disorder.
1. 5lauco*a
$. +ctopia lentis
%. Cataracts
'. Posterior su#casular lentiular
opacity
(. Hetinitis pi&*entosa
).
A
$1
)
1n which of the followin&
5enoder*atoses would one 6nd
cutaneous hyperpi&*entation: #lue
lunulae and Kayser"2leishcher rin&s:
1. MarfanGs 0isease
$. Fe*ochro*atosis
%. 5aucherGs 0isease
'. ,ilsonGs 0isease
(. 9steo&enesis 1*perfecta
).
0
$1
A
,hich of the followin& syndro*es is
associated with *arkedly increased
1&+ le3els: cold a#scesses and a
characteristic coarse facies.
1. ,iskott"Aldrich syndro*e
$. Chronic &ranulo*atous disease
%. 7o# syndro*e
'. Se3ere co*#ined
i**unode6ciency
(. 8einerGs disease
).
C
$1
C
1chthyosis linearis circu*-e<a is one of
the 6ndin&s seen in the syndro*e
caused #y which of the followin&
&enes.
1. SP1EK(
$. S8BHP1
%. 57B$
'. 8MO1B
(. CS80
).
A
$1
D
1chthyosis hystri< is characteri;ed #y
the followin& &ene defects.
1. Keratins 1 and D
$. Keratins 1 and 1!
%. Keratins ( and 1'
'. Keratins ) and 1)
(. Eone of these answers are
correct
).
B
$$
!
,hich of the followin& syndro*es is
associated with cutis *ar*orata.
1. EethertonJs
$. Papillon"8efe3re syndro*e
%. Fe*ansky"Pudlak syndro*e
'. MaMucci syndro*e
(. Cornelia de 8an&e syndro*e
).
+
$$
1
Spastic ditetraple&ia is associated with
which of the followin& disorders.
1. S4o&ren"8arsson syndro*e
$. O"linked ichthyosis
%. 8a*ellar ichthyosis
'. K10 syndro*e
(. Hefsu* syndro*e
).
A
$$
$
Ea<os syndro*e is characteri;ed #y a
ri&ht sided cardio*yopathy: wooly
hair: and keratoder*a. /he epider*al
structure defecti3e in Ea<os syndro*e
is:
1. 0es*o&lein 1
$. 0es*o&lein %
%. Plako&lo#in
'. 0es*oplakin
(. Keratin 11!
).
C
$$
%
A 11 year"old fe*ale patient with
hypoparathyroidis* is referred to your
1. +ctoder*al dysplasia
$. 1nsulin dependent dia#etes
0
(A
clinic secondary to chronic
*ucocutanous candidiasis which is
refractory to standard treat*ents. /he
patient also has *ala#sorption and
se3ere chronic diarrhea. Sou deter*ine
that she has autoi**une
polyendocrinopathy"candiasis"
ectoder*al dystrophy
syndro*e=AP+C+0>. Since only two of
three *a4or criteria are needed to
*ake this dia&nosis: this patient
ha3in& de*onstrated
hypoparathyroidis* and chronic
*ucocutanous candidiasis is
dia&nosed with AP+C+0. ,hat is the
third *a4or criteria that would Lualify a
patient to *eet the dia&nosis of
AP+C+0.
*ellitus
%. Chronic autoi**une hepatitis
'. AddisonGs disease
(. Fypothyroidis*
).
$$
'
,hat is the *ost likely nail 6ndin&s in
a patient who has this autoso*al
do*inant disease with these keratotic
papules and co##lestonin& of the oral
*ucosa.
1. Koilonychia
$. Hed and white lon&itudinal
#ands
%. Melanonychia
'. Falf and half nails
(. Pincer nails
).
B
$$
(
/he &ene defect in 5riscelli Syndro*e
is:
1. Myosin ?a or Ha#$Aa
$. 8SS/ or CFS1
%. P &ene
'. /HP1
(. Eone of these answers are
correct
).
A
$$
)
A patient with a white: spon&y
o3er&rowth of the #uccal *ucosa that
has passed in an autoso*al do*inant
fashion is *ost likely related to a
*utation in which of the followin&.
1. Keratin 11!
$. Keratin )#1A
%. Keratin '1%
'. Keratin )a1)
(. Eone of these options are
correct
).
C
$$
A
Sphenoid win& dysplasia is seen in: 1. /u#erous sclerosis
$. /ay Syndro*e
%. Mafucci syndro*e
'. E2"1
(. E2"$
).
0
$$
C
Adenosine dea*inase de6ciency is
associated with which of the followin&
disorders.
1. ,iskott Aldrich syndro*e
$. 5out
%. 7o# syndro*e
'. Oeroder*a pi&*entosu*
(. Se3ere co*#ined
i**unode6ciency
).
+
$$
D
A child presents with sparse: short hair
and sensorineural deafness. 9n
*icroscopic e<a*ination of the hair:
1. B4ornstad syndro*e
$. Menkes kinky hair syndro*e
%. Ar&ininosuccinic aciduria
A
(C
pili torti is noted. ,hich of the
followin& syndro*es is the *ost likely
dia&nosis.
'. /richothiodystrophy
(. Eone of the options are correct
).
$%
!
+yelid strin& of pearls are seen in
which of the followin& conditions.
1. 2ocal der*al hypoplasia
$. 8ipoid proteinosis
%. Futchinson"5ilford syndro*e
'. Beare"Ste3enson cutis &yrata
syndro*e
(. 5aucherJs disease
).
B
$%
1
Beckwith",ieder*an syndro*e is
characteri;ed #y which of the followin&
triads.
1. Fe*an&io#lasto*as: renal
cysts and renal cell carcino*a
$. +pista<is: telan&ictases: and
&astrointestinal tract #leedin&
%. +nlar&ed li*#: port wine stain:
and deep 3enous thro*#osis
'. 9*phalocele: 3enous
*alfor*ations: and ata<ia
(. +<o*phalos: *acro&lossia: and
&i&antis*
).
+
$%
$
A child has ichthyosis and is found to
ha3e leukocytes with 3acuoles 6lled
with lipids on peripheral s*ear. She
*ost likely has:
1. Chanarin"0orf*an syndro*e
$. 1chthyosis hystri<
%. Ea<os disease
'. 1chthyosis #ullosa of Sie*ens
(. 1chthyosis 3ul&aris
).
A
$%
%
An&ioid streaks on retinal e<a* are
characteristic of which of the followin&
syndro*es.
1. Pseudo<antho*a elasticu*
$. Choroid *alfor*ations
%. +yelid papillo*as
'. 8ester iris
(. Salt @ pepper retinitis
pi&*entosa
).
A
$%
'
,hich of the followin& syndro*es is
associated with trichole**o*as.
1. Birt"Fo&&"0u#e
$. Brooke"Spie&ler
%. Bannayan"Hiley"Hu3acal#a
'. Base<
(. Has*ussenGs
).
C
$%
(
A child presents with the hair 6ndin&
seen in the i*a&e in addition to #rittle
nails: keratosis pilaris: a#nor*al teeth
and cataracts. ,hich of the followin&
a#nor*alities is the *ost likely
*utated.
1. Keratin 11!
$. Keratin hF#1hF#)
%. Keratin )1)
'. Keratin )1A
(. Keratin $e
).
B
$%
)
/he &ene defect in 8+9PAH0 syndro*e
is:
1. P/PE11
$. PHKAH1A
%. K1P$
'. A/M
(. Eeuro6#ro*in
).
A
$%
A
He&ardin& the inheritance of +hlers"
0anlos syndro*e: which su#type is
inherited in an O"linked recessi3e
1. /he type with the lysyl o<idase
de6ciency
$. /he type with the lysyl
A
(D
*anner. hydro<ylase de6ciency
%. /he type with a colla&en (
defect
'. /he type with a colla&en %
defect
(. /he type with a defect in
procolla&en a*inopeptidase
).
$%
C
Patients with ho*ocystinuria are
de6cient in:
1. Alpha &alactosidase A
$. /rans&luta*inase
%. 8ysyl o<idase
'. Cystathionine synthetase
(. Steroid sulfatase
).
0
$%
D
A patient presents with #ilateral retinal
he*an&io#lasto*as and a capillary
*alfor*ation on her neck. ,hich &ene
*utation is *ost likely.
1. ?F8
$. +ndo&lin
%. P/FP/FrP type 1 receptor
'. ?+52 receptor"%
(. M2F1
).
A
$'
!
A 1C yo *an presents for e3aluation of
foot lesions. /here are thick
hyperkeratotic plaLues sy**etrically
on only the wei&ht #earin& plantar
surfaces. ,hat test=s> should this
patient #e referred for.
1. Fead C/
$. /horacic C/
%. Fepatic ultrasound
'. +ndoscopy
(. Knee 6l*s
).
0
$'
1
,hich disease can clinically *i*ic
pella&ra #ut is inherited in an
autoso*al recessi3e fashion and is due
to a defect in the transport of neutral
a*ino acids.
1. ,ilsons
$. Fe*ochro*atosis
%. Fartnup 0isease
'. 2a#ry
(. 5aucherJs
).
C
$'
$
Meleda is an island oM the coast of
Croatia. 1ts inha#itants ha3e an
increased freLuency of a *alodorous
trans&radiens pal*oplantar
keratoder*a in a stockin&"&lo3e
distri#ution. /his condition is
autoso*al recessi3e with a defect in:
1. S8BHP1 &ene
$. Keratin 1D
%. /9C &ene
'. 8oricrin
(. Cathepsin C
).
A
$'
%
Co**a"shaped corneal opacities are
characteristic of which type of
ichthyosis.
1. 1chthyosis 3ul&aris
$. O"linked ichthyosis
%. 8a*ellar ichthyosis
'. Eon#ullous con&enital
ichthyosifor* erythroder*a
(. Hefsu* syndro*e
).
B
$'
'
Acropi&*entation of 0ohi is
characteri;ed #y:
1. Heticulated pi&*entation of the
a<illae: neck: and &roin
$. 8inear pal*ar pits and
pi&*ented *acules on 3olar and
dorsal hands and feet
%. Pi&*ented and depi&*ented
*acules on the distal dorsal
e<tre*ities and face
'. Fyperpi&*ented *acules on
C
)!
the lips and oral *ucosa
(. 2laccid: super6cial pustules
that #urst and lea3e pi&*ented
*acules
).
$'
(
Patients with Fer*ansky"Pudlak
syndro*e *ay e<perience which of
the followin& syste*ic co*plications
as a result of their disease.
1. Arterio3enous *alfor*ations
$. Pul*o*ary 6#rosis
%. 5astroesopha&eal re-u<
disease
'. Aortic stenosis
(. Hectal a#scesses
).
B
$'
)
A patient with *ultiple lenti&ines and
#lue ne3i *ay also ha3e:
1. 0eafness
$. Pul*onary 3al3e stenosis
%. Atrial *y<o*a
'. Mental retardation
(. 51 *ali&nancy
).
C
$'
A
5er*line K1881E *ethylation is
associated with which of the followin&
syndro*es.
1. Bannayan"Hiley"Hu3alca#a
Syndro*e
$. Proteus Syndro*e
%. Cowden Syndro*e
'. Birt"Fo&&"0u#e Syndro*e
(. 5alli"5alli 0isease
).
C
$'
C
Pri*ary pi&*ented nodular
adrenocortical disease and
psa**o*atous *elanotic
schwanno*as are characteristic of
which of the followin& syndro*es.
1. Fypo*elanosis of 1to
$. Carney co*ple<
%. McCune"Al#ri&ht syndro*e
'. 5aucherJs syndro*e
(. /u#erous sclerosis
).
B
$'
D
0e6ciency of 6la&&rin is the stron&est
known predisposin& &enetic factor for
the de3elop*ent of atopic der*atitis.
,hat is the *ode of inheritance of
*utations in 6la&&rin.
1. Autoso*al do*inant
$. Autoso*al se*ido*inant
%. Autoso*al recessi3e
'. O"linked do*inant
(. O"linked recessi3e
).
B
$(
!
Ee3oid #asal carcino*a syndro*e
=5orlin syndro*e> is autoso*al
do*inant trans*itted *utation of the
patched &ene. Sy*pto*s include
innu*#era#le #asal cell carcino*as:
painful odonto&enic 4aw keratocysts:
pal*oplantar pits: frontal #ossin&: #i6d
ri#s and what other #ony a#nor*ality.
1. Polyostotic 6#rous dysplasia
$. Stippled epiphyses
%. Calci6cation of fal< cere#ri
'. 9steopoikilosis
(. Sphenoid win& dysplasia
).
C
$(
1
A patient Buschke"9llendorM syndro*e
has osteopoikilosis and which
cutaneous 6ndin&.
1. ,a<y papules alon& the eyelids
$. CafJ au lait *acules
%. Port wine stain
'. 7u3enile elasto*a
(. +pider*al ne3i
).
0
$(
$
/he dia&nostic test for chronic
&ranulo*atous disease is:
1. 0i*ethyl&lyo<i*e test
$. Eitro#lue tetra;oliu* reduction
assay
%. Fista*ine skin test
B
)1
'. Bone *arrow #iopsy
(. Potassiu* hydro<ide
).
$(
%
+pider*olysis #ullosa si*ple< is
caused #y #listerin& in which
structure.
1. 5ranular layer keratinocyte
$. Spinous layer keratinocyte
%. Basal layer keratinocyte
'. 8a*ina densa
(. Su#la*ina densa
).
C
$(
'
A child with phenylketonuria likely
presents with which cutaneous
pro#le*s.
1. Blue"&ray &enerali;ed
hyperpi&*entation
$. Alopecia uni3ersalis
%. 5enerali;ed hypopi&*entation
'. 5enerali;ed hyperpi&*entation
(. 8e& ulcers
).
C
$(
(
,hich of the followin& 6ndin&s is
characteristic of a *utation in la*in A.
1. 8ipoatrophic scleroder*oid skin
$. Alopecia
%. Cranio*e&aly with s*all face
'. Se3ere pre*ature
atherosclerosis with early death
(. All of the answers are correct
).
+
$(
)
A patient with port wine stain on a
lower e<tre*ity: he*ihypertrophy of
the li*# and ly*phatic and deep
3enouse insuTciency of the aMected
li*# would #e considered to ha3e
Klippel"/renaunay",e#er syndro*e.
,hat additional feature would need to
#e present to de6ne the patient as
ha3in& Parkes",e#er syndro*e.
1. Arterio3enous 6stulas
$. Multiple cafe"au"lait *acules
%. Macro&lossia
'. Cutis *ar*orata
(. 0istichiasis
).
A
$(
A
,hat is the &enetic defect of this
autoso*al do*inant disorder.
1. P/+E
$. P/PE11
%. Calciu* A/Pase $A$
'. Calciu* A/Pase $C1
(. SP1EK(
).
0
$(
C
A patient with *ultiple facial
trichile**o*as is at risk of which of
the followin& cancers.
1. Basal cell carcino*a
$. Breast carcino*a
%. Acute leuke*ia
'. Cylindro*a
(. 9ral sLua*ous cell carcino*a
).
B
$(
D
Birt"Fo&&"0u#e syndro*e is *ost
stron&ly associated with which of the
followin& *ali&nancies.
1. Basal cell carcino*a
$. Medullo#lasto*a
%. Henal cell carcino*a
'. /richoepithelial carcino*a
(. +ccrine syrin&o6#roadeno*a
).
C
$)
!
Adenosine dea*inase de6ciency is
seen in which i**unode6cient
disease.
1. ,iskott"Aldrich syndro*e
$. Chronic &ranulo*atous disease
%. 7o# syndro*e
'. Se3ere co*#ined
i**unode6ciency syndro*e
0
)$
(. 8eineriGs disease
).
$)
1
/yrosinase positi3e al#inis*
=oculocutaneous al#inis* type $> is
caused #y a *utation in which of the
followin&:
1. /yrosinase
$. P &ene
%. /yrosinase related protein 1
'. C"kit
(. E+M9
).
B
$)
$
2indin&s of *ilia: cylindro*as and the
condition shown in the patholo&y
i*a&e are characteristic of which of
the followin& syndro*es.
1. 5orlinGs syndro*e
$. 2a*ilial cylindro*atosis
%. Brook"Spie&ler syndro*e
'. Has*usen syndro*e
(. Ho*#o syndro*e
).
C
$)
%
+nchondro*as and chondrosarco*as
are *ost stron&ly associated with
which of the followin& syndro*es.
1. Proteus syndro*e
$. 9sler",e#er"Hendu syndro*e
%. MaMucci syndro*e
'. Eonne"Milroy disease
(. Blue ru##er #le# ne3us
syndro*e
).
C
$)
'
,hich eye 6ndin&s would #e e<pected
in an indi3idual with this disorder
associated with atherosclerosis.
1. 0endritic corneal ulcerations
$. Salt and pepper retinitis
pi&*entosa
%. +ctopia lentis
'. An&oid streaks
(. Keratoconus
).
0
$)
(
/he coast of Maine cafe au lait *acule
is a co**on 6ndin& in which of the
followin& syndro*es.
1. /u#erous Sclerosis
$. Eeuro6#ro*atosis type 1
%. McCune"Al#ri&ht syndro*e
'. ,atson syndro*e
(. Hussell"Sil3er syndro*e
).
C
$)
)
1chthyosifor* erythroder*a in lines of
Blaschko: follicular atrophoder*a: and
stippled epiphyses are characteristic of
which of the followin& disorders.
1. Hefsu* syndro*e
$. Chondrodysplasia punctata
%. +rythrokeratoder*ia 3aria#ilis
'. Eetherton syndro*e
(. S4o&ren"8arsson syndro*e
).
B
$)
A
,hich of the followin& *etals is
de6cient in the seru* of patients with
Menkes kinky hair syndro*e.
1. Copper
$. 1ron
%. Seleniu*
'. Kinc
(. Biotin
).
A
$)
C
A patient with *yotonic dystrophy and
*ultiple skin lesions *ost likely has
acti3atin& *utations in which of the
followin&.
1. Beta"catenin
$. 0es*oplakin
%. Plako&lo#in
'. 0es*o&lein
(. Alpha )"#eta ' inte&rin
).
A
$)
D
,hich of the followin& #ony defect is
found in CF180 syndro*e.
1. Polyostotic 6#rous dysplasia
$. Stippled epiphyses
%. Calci6cation of fal< cere#ri
B
)%
'. 9steopoikilosis
(. Sphenoid win& dysplasia
).
$A
!
,hat is the *ost likely &ene *utation
in this indi3idual who has *i&ratory
patches and 6<ed plaLues as depicted
in this picture.
1. Conne<in $)
$. Conne<in %!.% and %1
%. Calciu* A/Pase $C1
'. 8oricrin
(. Keratins 1 and 1!
).
B
$A
1
A 1$ year"old #oy with pits on his
pal*s and lateral 6n&ers *ay ha3e:
1. Arsenic e<posure
$. A hereditary keratoder*a
%. A coryne#acteria infection
'. An inherited cancer syndro*e
(. Secondary syphilis
).
0
$A
$
,hich of the followin& syndro*es is O"
linked do*inant.
1. Anhidrotic ectoder*al dysplasia
$. 0yskeratosis con&enita
%. O"linked icthyosis
'. 9rofaciodi&ital syndro*e 1
(. Menkes kinky hair syndro*e
).
0
$A
%
Conne<in %! =57B) &ene> is defecti3e
in which of the followin& syndro*es.
1. K10 syndro*e
$. ?ohwinkel syndro*e
%. ?ohwinkel syndro*e 3ariant
'. Clouston syndro*e
(. +rythrokeratoder*a 3aria#ilis
).
0
$A
'
Patients with Hussell"Sil3er syndro*e
e<hi#it:
1. Clinodactyly of 6fth 6n&er
$. Pe& teeth
%. 9steopathia striata
'. Broad thu*#s
(. Shortened 'th and (th
*etacarpals
).
A
$A
(
,hich of the followin& diseases is seen
only in fe*ales.
1. 5riscelli syndro*e
$. Pie#aldis*
%. Fypo*elanosis of 1to
'. 1ncontinentia pi&*enti
(. Carney co*ple<
).
0
$A
)
/he characteristic dental 6ndin&s in
patients with tu#erous sclerosis are:
1. Pe& teeth
$. Anodontia
%. +na*el pits
'. 9donto&enic cysts
(. Hetention of pri*ary teeth
).
C
$A
A
Sou are consulted on a patient with
possi#le Eethertons Syndro*e. ,hich
location of the #ody would *ost likely
ha3e hairs de*onstratin& trichorrhe<is
in3a&inata.
1. Scalp
$. +ye#row
%. +yelash
'. All of these answers are correct
(. Eone of these answers are
correct
).
B
$A
C
/o help dia&nose trichothiodystrophy:
which of the followin& le3els are
1. Ar&inine
$. Fistidine
+
)'
decreased in hairs of aMected
indi3iduals.
%. Phenylalanine
'. 5lycine
(. Cysteine
).
$A
D
,hich one of the followin& is the *ost
co**on onco&enic 3irus in patients
with epider*odysplasia 3errucifor*is.
1. FP?"(
$. FP?"C
%. FP?"1%
'. FP?"1)
(. FP?"%%
).
A
$C
!
A patient with hypohydrosis and
hyperpyre<ia: anodontia: and sparse
hair has which syndro*e:
1. 0yskeratosis con&enita
$. Pachyonychia con&enita
%. Anhidrotic ectoder*al dysplasia
'. Fidrotic ectoder*al dysplasia
(. Papillon 8efe3re
).
C
$C
1
Sou are e<a*inin& a child with *ild
al#inis*: i**unode6ciency and sil3er
&rey hi&hli&hts in his hair. Sou
dia&nose the child with Chediak"
Fi&ashi syndro*e. ,hy are you
con6dent that this isnJt 5riscelli
syndro*e.
1. 5iant lysoso*al &ranules are
present in neutrophils in the #lood
s*ear
$. 5riscelli syndro*e does not
ha3e al#inis* as a feature
%. 5riscelli syndro*e has no
chan&es in hair color
'. All of these answers are correct
(. Eone of these answers are
correct
).
A
$C
$
MenkeJs kinky hair syndro*e is
caused #y a defect in:
1. Mitochondrial &ene
$. 0EA helicase
%. 5ap 4unction protein
'. Copper /ransportin& A/Pase
(. Proto"onco&ene
).
0
$C
%
All of the followin& disorders are
e<acer#ated #y B? radiation e<cept:
1. Bloo* syndro*e
$. FartnupJs disease
%. Hefsu* syndro*e
'. Cockayne syndro*e
(. Hoth*und"/ho*opson
syndro*e
).
C
$C
'
A patient with Bloo* Syndro*e is
*ost likely to ha3e which la#oratory
a#nor*alities:
1. 0ecreased i**uno&lo#ulins
$. Macrocytic ane*ia
%. +le3ated 1&+
'. /hro*#ocytopenia
(. Positi3e AEA
).
A
$C
(
,hich of the followin& eye 6ndin&s is
caused #y the rupture of BruchGs
*e*#rane.
1. An&ioid streaks
$. Blue sclerae
%. Hetinal detach*ent
'. Huptured &lo#e
(. Keratoconus
).
A
$C
)
Pili trian&uli et canaliculi is
characteristic of which of the followin&
syndro*es.
1. Bnco*#a#le hair syndro*e
$. B4ornstad syndro*e
%. Menkes kinky hair syndro*e
A
)(
'. 8einers disease
(. EethertonGs syndro*e
).
$C
A
Patients with pro&eria typically die of
which of the followin& conditions.
1. 1nfection
$. Metastatic carcino*a
%. Atherosclerotic heart disease
'. Eail atrophy
(. Pro&ressi3e syste*ic sclerosis
).
C
$C
C
,hat is the &enetic defect of this
syndro*e.
1. ABCA1$ &ene
$. /rans&luta*inase 1 =/5M1>.
%. 57B$ =conne<in $)> &ene.
'. Steroid sulfatase =S/S> &ene
(. Pro6la&&rin &ene
).
A
$C
D
Pal*oplantar keratoder*a with
deafness is caused #y a defect in
which &ene.
1. S8BHP"1
$. Plakophilin
%. Mitochondrial serine
transferase HEA
'. 8ysoso*al papain like cysteine
proteinase
(. Bnknown
).
C
$D
!
1n #iopsies fro* #listers in patients
with 4unctional epider*olysis #ullosa:
the split is found in the:
1. Basal cell layer of the epider*is
$. 8a*ina lucida
%. 8a*ina densa
'. SLua*ous cell layer of the
epider*is
(. Eone of the answers are correct
).
B
$D
1
,hich of the followin& is the 6rst
sy*pto* of ata<ia telan&iectasias.
1. Con4uncti3al telan&ictases
$. 2acial telan&iectases
%. Fe*atolo&ic *al&i&nancy
'. Cere#ellar ata<ia
(. Breast cancer
).
0
$D
$
,hich of the followin& is not a feature
of Cockayne syndro*e.
1. 0war6s*
$. Salt and pepper retina
%. 1ncreased sister chro*atid
e<chan&e
'. 1ncreased risk of skin cancer
(. Poikiloder*a
).
0
$D
%
A patient with coarse facies: #road
nasal #rid&e: and e<tensi3e ec;e*a
*i&ht #e e<pected to ha3e which
a#nor*al la#oratory 3alue.
1. Fypertri&lyceride*ia
$. Fi&h Copper le3els
%. 8ow Kinc le3els
'. Fi&h 1&+ le3els
(. Ane*ia
).
0
$D
'
Patients with Chondrodysplasia
punctata can ha3e 6ndin&s of stippled
epiphyses on O"ray e<a*ination.
,hich other <"linked do*inant
condition can ha3e stippled epiphyses.
1. CF180 syndro*e
$. 1ncontinentia Pi&*enti
%. 2ocal 0er*al Fypoplasia
'. 5olt; syndro*e
(. Ba;e< syndro*e
).
A
))
$D
(
,hich of the followin& features is not
associated with Cornelia de 8an&e
Syndro*e.
1. Eor*al intelli&ence
$. Characteristic facies with
downturned *outh: hirsutis*:
synophrys: tricho*e&aly:
ante3erted nostrils: lon& philtru*
and low set ears
%. Cryptorchidis*
'. 2ifth 6n&er clinodactyly
(. Hecurrent lun& infections
).
A
$D
)
Cutaneous *enin&io*as ha3e #een
associated with what syndro*e.
1. Eeuro6#ro*atisis
$. Cowden
%. Eeurocutaneous *elanosis
'. 5orlin
(. 5lo*an&io*atosis
).
A
$D
A
,hat is the *ost likely syndro*e that
this wo*an has in this photo&raph.
1. A. Klippel /renaunay ,e#er
$. 2ilariasis
%. Eeuro6#ro*atosis
'. Proteus syndro*e
(. /urner syndro*e
).
A
$D
C
A patient presents with star6sh
keratoses: pseudoainhu*:
honeyco*#ed PPK: and &enerali;ed
ichthyosis. ,hat is the *ost likely
&enetic defect.
1. Conne<in %1
$. Conne<in $)
%. Conne<in %!
'. 8oricrin
(. Conne<in %%
).
0
$D
D
A 1A yo *an presents with facial acne
that he would like treated. Sou notice
that he has 6ne #rown scale on his
neck and do a co*plete skin e<a*.
/his scale is present on the re*ainder
of his #ody: sparin& his pal*s: soles
and -e<ural areas. Fe infor*s you that
his uncles on his *otherJs side ha3e
si*ilar skin 6ndin&s. Fe is not
concerned a#out the skin and would
like to proceed with acne treat*ent
only. ,hat other clinical e<a* should
you perfor* to screen for a potential
*ali&nancy to which this patient is at
hi&her risk for acLuirin&.
1. /esticular
$. A#do*inal
%. 8y*ph node
'. 8un&
(. Hectal
).
A
%!
!
,hich of the followin& conditions is
inherited in an O"linked recessi3e
*anner.
1. +pider*olysis #ullosa si*ple<
$. 1chthyosis 3ul&aris
%. S4o&ren"8arsson syndro*e
'. ,iskott"Aldrich Syndro*e
(. EethertonJs Syndro*e
).
0
%!
1
,hich of the followin& is a potentially
serious co*plication of the #lue ru##er
#le# ne3us syndro*e.
1. 0e3elop*ent of
chondrosarco*as
$. 0e3elop*ent of an&iosarco*as
%. 5astrointestinal he*orrha&e
'. 0e3elop*ent of ly*phede*a
(. 0e3elop*ent of -uid retention
C
)A
).
%!
$
1chthyosis #ullosa of Sie*ens is a
condition characteri;ed #y fra&ile
#listers at #irth: hyperkeratotic
plaLues on el#owsknees later in life:
and a &ene *utation in:
1. Keratin $e
$. Keratin (1'
%. Keratin )a1)
'. Keratin 11!
(. Eone of these options are
correct
).
A
%!
%
Cronkhite"Canada is associated with
&astrointestinal polyposis: nail atrophy:
alopecia: &enerali;ed pi&*entation of
skin and *elanotic *acules on the
6n&ers. ,hich of the followin&
descri#es its inheritance pattern.
1. Autoso*al recessi3e
$. Autoso*al do*inant
%. O"linked recessi3e
'. O"linked do*inant
(. Sporadic
).
+
%!
'
A child presents with *acro&lossia:
e<opthal*os and &i&antis*. Fe has a
history of o*phalocele repair and has
circular depressions on the ri* of the
posterior helices. Althou&h this
syndro*e is *ost often trans*itted in
a sporadic *anner: 1(N of cases ha3e
defects in which &ene.
1. K1P$
$. A/M
%. ?F8
'. 28/'
(. 29OC$
).
A
%!
(
,hat is the &ene defect in harleLuin
fetus.
1. /rans&luta*inase
$. Steroid sulfatse
%. ABCA1$
'. ABCC)
(. Eone of these answers are
correct
).
C
%!
)
Hetention of pri*ary teeth a dental
6ndin& of which of the followin&
conditions.
1. Fypo*elanosis of 1to
$. 8etterer"Siwe disease
%. /u#erous sclerosis
'. 7ackson Sertoli syndro*e
(. Fyper"1&+ syndro*e
).
+
%!
A
/he hair a#nor*ality shown in the
i*a&e is characteristic of which of the
followin& diseases.
1. Ea<os disease
$. /richothiodystrophy
%. B4ornstad syndro*e
'. Monilethri<
(. All of the options are correct
).
B
%!
C
Sellow"#rown depositions in
0esce*etGs *e*#rane of the corneas
is dia&nostic for:
1. Fe*ochro*atosis
$. Eeuro6#ro*atosis
%. Fepatolenticular de&eneration
'. Pseudo<antho*a elasticu*
(. 0ia#etes *ellitus
).
C
%!
D
Medullo#lasto*as are seen in which of
the followin& syndro*es.
1. Ba;e< syndro*e
$. 2a*ilial cylindro*atosis
%. Eicolau"Balus syndro*e
'. Birt"Fo&&"0u#e syndro*e
(. Ee3oid #asal cell carcino*as
syndro*e
).
+
)C
'. 5eneral 0er*atolo&y
# Question Answers Ans
1 /he *ost co**on 6ndin& in patients with
syste*ic sclerosis is:
1. Mi&ratory polyarthritis
$. +sopha&eal dysfunction
%. Pul*onary 6#rosis
'. Henal disease
(. Cardiac conduction defects
). Show +<plaination
B
$ /he causati3e or&anis* for *ucocutaneous
leish*aniasis is:
1. 8eish*ania aethiopica
$. 8eish*ania infantu*
%. 8eish*ania #rasiliensis
'. 8eish*ania tropica
(. 8eish*ania *a4or
). Show +<plaination
C
% /he 6rst site in #ody that shows yellowish
pi&*entation in carotenoder*a is
1. 2ace
$. /runk
%. Pal*s and soles
A
)D
'. Eails
(. Sclera
). Show +<plaination
' 1ncreased chylo*icrons are a feature of which
type of hyperlipoproteine*ia.
1. /ype 1
$. /ype 11a
%. /ype 11#
'. /ype 111
(. /ype 1?
). Show +<plaination
A
( ,hich anti#ody is D%N speci6c for S4o&renGs
syndro*e.
1. anti"Ho
$. anti"8a
%. anti"fodrin
'. anti"Schir*er
(. H2
). Show +<plaination
C
) Solid con-uent pal*oplantar keratosis: sal*on"
oran&e follicular papules and diMuse
sy**etrical in3ol3e*ent with characteristic
s*all islands of nor*al skin within aMected
areas are all clinical characteristics of what skin
disease.
1. 8ichen Sclerosis
$. 0er*ato*yosistis
%. Phrynoder*a
'. Heiter\]^ ^Ys syndro*e
(. Pityriasis ru#ra pilaris
). Show +<plaination
+
A /his wo*an has restricted a#ility to open her
*outh with ti&ht #ound down skin of her hands
and pul*onary 6#rosis. 1n addition to a positi3e
AEA with a nucleolar pattern: what is the *ost
co**on autoi**une anti#ody that is
associated with pul*onary 6#rosis.
1. /opoiso*erase 1 anti#odies =for*erly Scl"A!>
$. 2i#rillarin anti#odies
%. Anti"B%HEP anti#odies
'. Anti"PM"Scl anti#odies
(. Anti"thyro&lo#ulin anti#odies
). Show +<plaination
A
C ,hich of the followin& is a feature of Schnit;lerGs
Syndro*e.
1. Monoclonal 1&5 &a**opathy
$. /hro*#oe*#olic e3ents
%. Bronchospas*
'. Fe*aturia
(. Sensori*otor neuropathy
). Show +<plaination
+
D ,hich of the followin& is an e<a*ple of a lar&e
3essel 3asculitis.
1. /akayasu arteritis
$. ,e&enerGs &ranulo*atosis
%. Chru&"Strauss syndro*e
'. Polyarteritis nodosa
(. Fenoch"Schonlein purpura
). Show +<plaination
A
1! 1n this patient with an autoi**une disorder:
which autoanti#ody would #e indicati3e of
increased risk of pul*onary disease.
1. B1HEP
$. 0s0EA
%. anti"7o"1 anti#ody
'. Mi"$ anti#ody
(. Scl"A! anti#ody
). Show +<plaination
C
11 ,hich state*ent #est descri#es the *echanis*
of action of spironolactone.
1. Eon"steroid inhi#itor of 0F/ #indin& to the
andro&en receptor
$. Pro&estin
%. 5nHF a&onist
'. Mineralocorticoid
(. Steroid inhi#itor of andro&en receptor and
andro&en #iosynthesis
). Show +<plaination
+
1$ A patient presents with lesion that can #e
herniated into the skin on palpation. ,hat is
thou&ht to #e i*portant in the patho&enesis of
this condition.
1. Calci6cation of the elastic 6#ers
$. 2or*ation of e<cessi3e colla&en
%. 2ocal loss of elastic tissue
'. Atrophy of the epider*is
(. 1n-a**ation of the panniculus
). Show +<plaination
C
1% /he lesions shown here are *ost likely to: 1. 9ccur in infants and elderly patients
$. 9ccur as an ad3erse reaction to *edication
%. Be refractory to treat*ent
'. 2ollow a streptococcal infection
(. +rupt after the appearance of a Jherald
patchJ
). Show +<plaination
0
1' BehcetGs disease is associated with which F8A
type.
1. F8A"B(1
$. F8A"B1A
%. F8A"B1%
'. F8A"0H'
(. F8A"Cw)
A
A!
). Show +<plaination
1( ,hich of the followin& is true re&ardin& this
entity.
1. +<tra&enital lesions co**only in3ol3e the
torso and are usually pruritic
$. Childhood onset is reported in _(N of cases
%. $!N of #oth *en and wo*en with this
dia&nosis ha3e at least one autoi**une
disease
'. 5irls outnu*#er #oys $:1
(. 5enital disease represents (!N of childhood
cases
). Show +<plaination
C
1) AcLuired C1 esterase inhi#itor de6ciency results
in:
1. A nor*al le3el of seru* C1L
$. A decreased le3el of seru* C1L
%. Eone of these answers are correct
'. A presentation of an&ioede*a 3ery early in
life
(. A nor*al le3el of C'
). Show +<plaination
B
1A ,hich of the followin& *edications is not
associated with e<acer#atin& this condition.
1. 8ithiu*
$. Prednisone
%. Phenytoin
'. 1sonia;id
(. Propranolol
). Show +<plaination
+
1C ,hich of the followin& is not a co**on food or
en3iron*ental aller&en i*plicated in atopic
der*atitis.
1. 0er*atopha&oides pteronyssi*us
$. ,heat
%. Corn
'. +&&s
(. 2ish
). Show +<plaination
C
1D HEP anti#odies include: 1. anti"SSA: anti"centro*ere: anti"SSB
$. anti"SSA: anti"SSB: anti"S*: anti"B1HEP
%. anti"SSA: anti"SSB: anti"S*: anti"ds0EA
'. AEA: anti"ds0EA
(. anti"SSA: anti"B1HEP: anti"centro*ere
). Show +<plaination
B
$! A 1) year old de3elop*entally nor*al *ale
presents to his pediatrician inter*ittent 3a&ue
epidodes of hand and feet paresthesias and non
speci6c episode of 51 distress. Fe is referred to
you to e3aluate nu*erous punctate to ( sli&htly
3errucous: deep"red to #lue"#lack papules
distri#uted diMusely on his trunk in a #athin& suit
distri#ution. Polari;ation *icroscopy of the
sedi*ent of his urine de*onstrates #irefrin&ent
lipid &lo#ules =ie: renal tu#ular epithelial cells or
cell fra&*ents with lipid inclusions> with the
characteristic Maltese cross con6&uration. ,hat
is the classic ocular 6ndin& in this disorder.
1. Pseudo"herpetic corneal ulcerations
$. Brush6eld spots
%. Fyperpi&*entation of the retinal epitheliu*
'. Corneal opacities
(. 8ester irides
). Show +<plaination
0
$1 A pre&nant wo*an in her third tri*ester
presents with nonpruritic erythe*atous plaLues
and pustules in the intertri&inous re&ions: the
trunk: and the e<tre*ities as well as syste*ic
sy*pto*s of *alaise and fe3er. ,hich
co*plication is *ost associated with this
condition.
1. Pre*ature la#or
$. Placental insuTciency
%. Eo risk to fetus or *other
'. S*all for &estational a&e
(. Microcephaly
). Show +<plaination
B
$$ A D"year"old #oy presents with calcinosis cutis:
perior#ital 3iolaceous erythe*a: and periun&ual
telan&iectasias. ,hich su#stance is *ost likely
to #e ele3ated in this patient.
1. 2odrin
$. 2i#rillarin
%. /hro*#ospondin"1
'. Co*ple*ent
(. /ri&lycerides
). Show +<plaination
C
$% 8acri*al &land in3ol3e*ent is characteristically
seen in patients with:
1. 8y*pho*a
$. Sarcoid
%. Hosacea
'. Syphilis
(. Pe*phi&us
). Show +<plaination
B
$' A child has a cutaneous ossi6cation disorder
characteri;ed #y endochondral #one for*ation:
deafness: #aldness: and *ental retardation.
,hich for* of osteo*a cutis does this patient
1. 2i#rodysplasia ossi6cans pro&ressi3a
$. Pro&ressi3e osseous heteroplasia
%. Plate"like osteo*a cutis
'. Al#ri&htGs hereditary osteodystrophy
A
A1
ha3e. (. Calcinosis cutis
). Show +<plaination
$( ,hich of the followin& is an innate anti*icro#ial
peptide e<pressed #y keratinocytes in response
to in4ury or in-a**ation.
1. A"defensin 1
$. A"defensin $
%. /E2"A
'. 18"'
(. 18"1%
). Show +<plaination
B
$) /his 3ariant of a*yloidosis is deri3ed fro*
de&enerated tono6la*ents of keratinocytes:
1. 8ichen a*yloidosis
$. Eodular a*yloidosis
%. Pri*ary syste*ic a*yloidosis
'. 0ialysis"related a*yloidosis
(. Secondary syste*ic a*yloidosis
). Show +<plaination
A
$A Pilo*atrico*as has #een associated with which
of the followin& conditions.
1. Acute *yelo&enous leuke*ia
$. Multiple sclerosis
%. Crohns 0isease
'. Myotonic dystrophy
(. Pneu*othora<
). Show +<plaination
0
$C P. acnes acti3ation of which of the followin& *ay
sti*ulate a pro"in-a**atory cytokine cascade.
1. /8H"$
$. /8H"(
%. 18"1
'. 18"C
(. /E2"!!!
). Show +<plaination
A
$D /eena&e #oys with se3ere: erupti3e cystic acne
and fe3er: leukocytosis: *yal&ias and other
constitutional sy*pto*s can ha3e which of the
followin& #ony chan&e.
1. 0i*plin& a#o3e the (th MCP
$. 9steolytic lesions of the cla3icle
%. 9steopoikilosis
'. Stippled epiphyses
(. 7aw cysts
). Show +<plaination
B
%! An o3erwei&ht: post"*enopausal wo*an
presents with intense pain in the fatty deposits
on her knees: thi&hs and hips. She also
descri#es swellin& of her hands and feet:
associated fati&ue: and history of depression. 9n
clinical e<a* the pain in the adipose tissue
appears out of proportion to the clinical 6ndin&s.
/he dia&nosis is:
1. An&iolipo*as
$. Adiposis dolorosa
%. Con&enital lipodystrophy
'. 8ipoder*atosclerosis
(. +rythe*a nodosu*
). Show +<plaination
B
%1 1ncreased 808 and ?808 is seen in which type of
hyperlipoproteine*ia.
1. /ype 11#
$. /ype 1
%. /ype 111
'. /ype 1?
(. /ype ?
). Show +<plaination
A
%$ A (!"year"old fe*ale with sarcoid has
enlar&e*ent of the parotid: su#*andi#ular: and
lacri*al &lands that is also known as:
1. Mikulic;Gs syndro*e
$. Feerfordt",aldenstro*n syndro*e
%. 0arier"Houssy sarcoid
'. 8of&renGs syndro*e
(. BlauGs syndro*e
). Show +<plaination
A
%% ,hat is the *ini*u* a*ount of ti*e that you
would ad3ise this wo*an to a3oid child#earin&
after co*pletin& a course of isotretinoin.
1. 1 week
$. 1 *onth
%. ) *onths
'. 1 year
(. % years
). Show +<plaination
B
%' ,hich of the followin& leukoder*as has a nor*al
nu*#er of epider*al *elanocytes.
1. Al#inis*
$. ?itili&o
%. Pie#aldis*
'. ,aarden#ur&Gs syndro*e
(. Kiprowski"Mar&olis syndro*e
). Show +<plaination
A
%( ,hich of the followin& is true re&ardin& topical
therapies for psoriasis.
1. ?ita*in 0% analo&ues deacti3ate salicylic
acid
$. Hetinoids are eMecti3e in decreasin& lesional
erythe*a
%. Anthralin can cause irre3ersi#le stainin& of
peri"lesional skin
'. Calcipotriol is deacti3ated #y B? li&ht
(. Anthralin inhi#its PMEs and *onocytes
+
A$
). Show +<plaination
%) A $! year old wo*an presents with a sunken
appearance to her face and trunk with nor*al
le&s. /he patient has attri#uted her appearance
to stress fro* colle&e: #ut is seein& you #ecause
of her fa*ilyGs concern. ,hat la# 6ndin& would
you e<pect in this patient
1. 0ecreased C% nephritic factor
$. 0ecreased C%
%. 0ecreased C1
'. 1ncreased C1
(. 1ncreased C'
). Show +<plaination
B
%A +osinophilia: asth*a: neuropathy and sinus
a#nor*alities are associated with which of the
followin& syste*ic 3asculitidies.
1. Chur&"Strauss syndro*e
$. Polyarteritis nodosa
%. Microscopic polyan&iitis
'. ,e&enerGs &ranulo*atosis
(. Kawasaki disease
). Show +<plaination
A
%C An atypical 6ndin& in patients with 8of&ren
syndro*e is.
1. 2e3er
$. Arthritis
%. Su#cutaneous /ender Eodules
'. Acute 1ritis
(. Beaded papules on nasal ri*
). Show +<plaination
+
%D Carcinoid tu*ors in which site do not lead to
-ushin& or other *anifestations of the carcinoid
syndro*e.
1. Appendi<
$. 1leu*
%. Ascendin& colon
'. Hectu*
(. Brochus
). Show +<plaination
0
'! Patients with this F8A type: which has the *ost
de6niti3e association with psoriasis: ha3e a
relati3e risk of ha3in& psoriasis that is D"1( ti*es
nor*al.
1. F8A"B1%
$. F8A"B1A
%. F8A"Bw(A
'. F8A"Cw)
(. F8A"B$A
). Show +<plaination
0
'1 ,hich of the followin& would #e an i*portant
dia&nostic si&n of this non"infectious disorder.
1. 8acri*al &land enlar&e*ent
$. Periun&ual 6#ro*as
%. Cafe"au"lait *acules
'. Pe& shaped teeth
(. 0ystopia canthoru*
). Show +<plaination
A
'$ /he risk of de3elopin& syste*ic in3ol3e*ent in a
patent with nodular a*yloidosis is:
1. 1"'N
$. ("1!N
%. $("%!N
'. (!")!N
(. `D(N
). Show +<plaination
B
'% /his patient also has poliosis and deafness. ,hat
is the associated ophthal*olo&ic 6ndin&.
1. Eor*al ophthal*olo&ic e<a*
$. Hetinal detach*ent
%. 8isch nodules
'. Corneal opacities
(. 5ranulo*atous u3eitis
). Show +<plaination
+
'' Sou prescri#e oral erythro*ycin to a %( year"old
wo*an. Co"ad*inistration of which of the
followin& *edications could lead to potential
ad3erse outco*es.
1. 9ral contracepti3es
$. ,arfarin
%. Car#a*a;epine
'. Methylprednisolone
(. ,arfarin: car#a*a;epine: or
*ethylprednisolone
). Show +<plaination
+
'( ,hat is the treat*ent of choice for this
condition:
1. /opical antifun&al *edication
$. Fi&h potency topical steroid
%. /opical anti#iotic crea*
'. 9ral anti#iotic
(. +<cision
). Show +<plaination
B
') ,hat is the *ost co**on paraproteine*ia in
sclero*y<ede*a.
1. 1&A
$. 1&5 kappa
%. 1&5 la*#da
'. 1&M
(. 1t is e<tre*ely unco**on to see a
paraproteine*ia with sclero*y<ede*a
). Show +<plaination
C
'A Fistolo&ic e<a*ination of this chronic pruritic
plaLue on the #ack: which of the followin& stains
1. ?on Kossa
$. Cotton dyes
A
A%
would E9/ #e positi3e. %. Crystal 3iolet
'. PAS
(. /hio-a3in /
). Show +<plaination
'C /he *ost eMecti3e treat*ent for sy*pto*atic
ocular rosacea is:
1. 8u#ricant eye drops
$. Co*#ination topical anti#iotic and
corticosteroid eye drops
%. 0ilute #a#y sha*poo washes
'. 0o<ycycline
(. Arti6cial tears
). Show +<plaination
0
'D Most often: <anthelas*a is associated with: 1. An 1&M paraprotein
$. An 1&5 paraprotein
%. Eo associated disease
'. /ype 1 hyperlipoproteine*ia
(. /ype 111 hyperlipoproteine*ia
). Show +<plaination
C
(! ,hat is the dia&nosis of this lesion on the penile
shaft.
1. Sclerosin& ly*phan&itis
$. 8oaloa
%. ?aricose 3ein
'. Syphilis
(. 8y*pho&ranulo*a 3enereu*
). Show +<plaination
A
(1 ,hat is the *ost likely dia&nosis. 1. ?oi&ht line
$. 8inea ni&ra
%. 2uchter line
'. Phytophotoder*atitis
(. 1ncontinentia pi&*enti
). Show +<plaination
B
($ A patient presents to the +H with skin pain and
lar&e sheets of epider*al detach*ent on &reater
than 1!N of his #ody surface area after startin&
#actri*. Eo purpuric *acules or tar&et lesions
are noted. ,hich of the followin& can help
predict *ortality in this patient.
1. &lucose &reater than 1(! *&d8
$. a&e o3er '! years
%. heart rate &reater than 1!!
'. history of dia#etes
(. BBE &reater than 1( *&d8
). Show +<plaination
B
(% Patients with 5ottronJs papules and periun&ual
telan&iectasias will likely ha3e a positi3e
serolo&ic test to which anti#ody.
1. Anti"SM
$. Scl"A!
%. Anti"Ho
'. Anti"centro*ere
(. Anti" 7o"1
). Show +<plaination
+
(' ,hat is the condition which is a dia&nostic
cutaneous *anifestation of sarcoid.
1. 0iscoid lupus
$. 8upus pernio
%. 8upus 3ul&aris
'. 5ranulo*atous rosacea
(. Hhinosclero*a
). Show +<plaination
B
(( ,hich of the followin& state*ents co*parin&
in-a**atory lesions fro* patients with psoriasis
and patients with atopic der*atitis is true.
1. Fu*an J"defensin $ =FB0"$> and 88 %A
le3els in psoriasis lesions are si&ni6cantly
lower than in atopic der*atitis lesions
$. +<pression of FB0"$ and 88 %A is ne&li&i#le
in psoriatic lesions
%. FB0"$ and 88 %A are si&ni6cantly ele3ated in
atopic der*atitis lesions
'. +<pression of FB0"$ and 88 %A in psoriasis is
si*ilar to nor*al skin: whereas it is
decreased in atopic der*atitis lesions
(. FB0"$ and 88 %A are si&ni6cantly decreased
in atopic der*atitis lesions co*pared to
psoriasis lesions
). Show +<plaination
+
() A patient with holocar#o<ylase synthetase
de6ciency is *ost at risk for de3elopin& a
de6ciency in:
1. Eiacin
$. Pyrido<ine
%. Biotin
'. Kinc
(. +ssential fatty acids
). Show +<plaination
C
(A Sou are suspicious for a new dia&nosis of lupus
in a patient recently treated with penicilla*ine.
,hich anti#odies would you e<pect to ha3e #een
induced #y this *edication.
1. anti"ds0EA
$. anti"histone
%. anti"SSA
'. anti"SSB
(. anti"Mi"$
A
A'
). Show +<plaination
(C ,hich cellular or&anelle is aMected in the partial
lidodystrophies.
1. Eucleolus
$. Hou&h endoplas*ic reticulu*
%. 5ol&i apparatus
'. Cell *e*#rane
(. Euclear la*ina
). Show +<plaination
+
(D Anti"7o"1 anti#odies in patients with
0er*ato*yositis are associated with:
1. Pul*onary 6#rosis
$. Cardiac disease
%. Photosensiti3ity
'. Calcinosis
(. Feliotrope rash
). Show +<plaination
A
)! Ci&arette s*okin& has #een shown to: 1. 1ncrease the incidence of BCC
$. Eot aMect the sur3i3al of sur&ical repairs
%. 0e*onstrate less solar elastosis than
photoa&ed skin
'. Fa3e no correlation with facial wrinklin&
(. 1ncrease cutaneous 3asoconstriction
). Show +<plaination
+
)1 A 'C year"old *an with a lon& history of alcohol
a#use and dependence presents with an&ular
cheilitis: atrophic &lossitis: a scrotal der*atitis
that spares the *idline and e<tends to the
thi&hs: photopho#ia: and #lepharitis. ,hich
nutritional de6ciency do you suspect.
1. ?ita*in B1$
$. ?ita*in C
%. Pyrido<ine
'. ?ita*in B$
(. 1ron
). Show +<plaination
0
)$ A $ year"old #oy with crusted skin papules is
found to ha3e osteolytic defects and dia#etes
insipidus. /hese features are seen in:
1. 9steo&enesis i*perfecta
$. Conradi"Funner*an disease
%. Metastatic s*all cell lun& carcino*a
'. Fand"Schuller"Christian disease
(. +pider*al ne3us syndro*e
). Show +<plaination
0
)% ,hat is the *ost co**on *ali&nancy
associated with this condition in this fe*ale.
1. Brain cancer
$. /hyroid cancer
%. Breast cancer
'. 93arian cancer
(. 8i3er cancer
). Show +<plaination
0
)' /he *a4ority of patients with positi3e B1HEP
autoanti#odies ha3e which dia&nosis.
1. Mi<ed connecti3e tissue disorder =MC/0>
$. Hheu*atoid arthritis
%. Syste*ic lupus erythe*atosus
'. S4o&renGs syndro*e
(. 0er*ato*yositis
). Show +<plaination
C
)( A '("year old wo*an fro* the Bnited States
de3elops erythe*a and swellin& around her
eyelids and sy**etric weakness of her
shoulders and hips. ,hat *ali&nancy is
o3errepresented in patients with this condition
co*pared to the &eneral population.
1. 93arian Cancer
$. 8un& Cancer
%. 8euke*ia
'. Bterine Cancer
(. Breast Cancer
). Show +<plaination
A
)) A ($ year"old *an presents with lar&e
co*edones as well as in-a**atory papules:
pustules: and cysts on the *alar cheeks:
postauricular scalp: and scrotu*. ,hich of the
followin& could #e a cause of this presentation.
1. +rlotini# che*otherapy
$. A pituitary adeno*a
%. $:%:A:C tetrachloro#en;odio<in e<posure
'. P/+E *utations
(. 1sotretinoin o3erdose
). Show +<plaination
C
)A 1n the a#sence of the C1 esterase inhi#itor:
which of the followin& proteins *ediates
an&ioede*a *ost directly:
1. Kallikrein
$. C1
%. Plas*in
'. C% con3ertase
(. C$ kinin
). Show +<plaination
+
)C /he pi&*entation shown here is *ost likely due
to which of the followin& dru&s.
1. ChloroLuine
$. A*iodarone
%. Minocycline
'. 0o<ycycline
(. /MP"SMO
). Show +<plaination
C
)D ,hat syste*ic condition is often associated with
this disease.
1. 0ia#etes *ellitus
$. /o#acco use
%. Alopecia areata
+
A(
'. Coronary artery disease
(. Fepatitis C
). Show +<plaination
A! Mali&nancy of the aerodi&esti3e tract is *ost
closely associated with which paraneoplastic
der*atosis.
1. Ba;e<Gs syndro*e
$. Paraneoplastic pe*phi&us
%. SweetGs syndro*e
'. Acanthosis ni&ricans
(. 0er*ato*yositis
). Show +<plaination
A
A1 A patient with a recent dia&nosis of tu#erculosis
on treat*ent presents with a new photosensiti3e
eruption on his face: neck and upper chest. 1n
addition: he has pro&ressi3e diarrhea and
depression. ,hat is the etiolo&y of his
sy*pto*s.
1. ?ita*in B1$ de6ciency
$. 0ru& induced pella&ra
%. 0ru& induced ri#o-a3in de6ciency
'. Carcinoid syndro*e
(. Photoaller&ic contact der*atitis
). Show +<plaination
B
A$ ,hich of the followin& is a clinical *anifestation
of neonatal lupus erythe*atosus:
1. Henal disease
$. Cere#ral 3ascular accident
%. Arthritis
'. /hro*#ocytopenia
(. Eeutrophilia
). Show +<plaination
0
A% ,hich of the followin& is true re&ardin& neonatal
lupus erythe*atosus.
1. Most cases in3ol3e #oys
$. 8esions &enerally resol3e spontaneously #y )
*onths: healin& with scarrin&
%. Photosensiti3ity is &enerally not a feature
'. A(N of *others ha3e sy*pto*atic syste*ic
lupus erythe*atous at the ti*e of deli3ery
(. Con&enital heart #lock *ay #e the only
*anifestation of the disease
). Show +<plaination
+
A' ,hat is the *ost co**on infection that can
cause &uttate psoriasis.
1. Streptococcus pyo&enes
$. Coccidio*ycosis
%. Ferpes
'. Mycoplas*a pneu*onia
(. /u#erculosis
). Show +<plaination
A
A( /he dia&nosis is: 1. Psoriasis
$. Alopecia areata
%. 9nycho*ycosis
'. 8ichen planus
(. /etracycline"induced photo"onycholysis
). Show +<plaination
A
A) A ($ year old patient with lon&standin& psoriasis
has #een treated with *ethotre<ate for the past
) *onths. Fe has had al*ost co*plete
clearance of his disease. Fe now co*plains of a
su#tle ri&ht upper Luadrant pain and nausea.
8a#oratory e3aluation of hepatic
a*inotransferases =AS/ and A8/> and #iliru#in
are within nor*al li*its. ,hich if the followin&
nonin3asi3e tests *ay #e helpful for *onitorin&
*ethotre<ate"induced hepatoto<icity.
1. C+A
$. transfor*in& &rowth factor #eta
%. tu*or necrosis factor alpha
'. Procolla&en 111 a*inopeptide
(. C% and C'
). Show +<plaination
0
AA Pro#iotics: which are cultures of potentially
#ene6cial &ut *icro-ora #acteria: ha3e #een
studied in the pri*ary pre3ention of which of the
followin& diseases.
1. Celiac disease
$. Atopic der*atitis
%. Psoriasis
'. Cutaneous /"cell ly*pho*a
(. Asth*a
). Show +<plaination
B
AC ,hich of the followin& is true re&ardin& acLuired
C1 esterase inhi#itor de6ciency.
1. /his condition &enerally occurs in the 6rst or
second decade of life
$. Seru* C1L is nor*al
%. C$ and C' are #oth decreased
'. C1 esterase inhi#itor *ay #e at nor*al le3els
with functional i*pair*ent
(. Positi3e fa*ily history is co**on
). Show +<plaination
C
AD A patientGs #iopsy is found to ha3e curled hair
shafts with hyperkeratotic plu&s. ,hich of the
followin& is not an associated feature of this
condition
1. Fypochondriasis
$. 5in&i3itis
%. 0elayed wound healin&
'. Eail chan&es
(. /ender nodules on the lower e<tre*ities
). Show +<plaination
0
A)
C! ,hich of the followin& *edications is *ost likely
to induce a -are of this patientGs disease.
1. cipro-o<acin
$. captopril
%. diphenhydra*ine
'. sertraline
(. aceto*inophen
). Show +<plaination
B
C1 /he der*atosis pictured is *ost co**only
associated with:
1. 1nsulin resistance
$. Cushin&Gs syndro*e
%. Acro*e&aly
'. Polycystic o3arian syndro*e
(. 5astric carcino*a
). Show +<plaination
A
C$ ,hich of the followin& is true re&ardin& the
co*ponents of a*yloid.
1. 5round su#stance is present only in
secondary cutaneous or tu*or"associated
a*yloidosis
$. /he a*yloid P co*ponent is present in all
for*s
%. Protein AA is present in pri*ary syste*ic
a*yloidosis
'. /he a*yloid present in secondary syste*ic
a*yloid does not lose its #irefrin&ence after
treat*ent with potassiu* per*an&anate
(. Protein A8 loses its #ire&rin&ence after
treat*ent with potassiu* per*an&anate
). Show +<plaination
B
C% /reat*ent of HaynaudGs pheno*enon includes: 1. Eifedipine
$. Metoprolol
%. B?B
'. /etracyline
(. Si*3astatin
). Show +<plaination
A
C' 1n addition to the lesions seen on the feet of this
youn& *an he also had &eo&raphic ton&ue:
erythe*atous plaLues on his penis and arthritis:
what F8A type is associated with this syndro*e.
1. F8A"B$A
$. F8A"B(1
%. F8A"0H1
'. F8A"0H%
(. F8A"0Q,$
). Show +<plaination
A
C( Acute he*orrha&ic ede*a of childhood is
distin&uished fro* Fenoch"Schonlein Purpura
#ased on:
1. /he presence of pupura on the upper trunk
$. /he lack of an antecedent infection
%. /he in3ol3e*ent of the syno3ia
'. /he neurolo&ic co*plications
(. /he lack of syste*ic features
). Show +<plaination
+
C) /he Iabfollicular occlusion triadI consists of: 1. Acne con&lo#ata: hidradenitis suppurati3a:
kerion
$. Acne con&lo#ata: chloracne: pyoder*a
faciale
%. Acne ful*inans: hidradenitis suppurati3a:
dissectin& cellulites of the scalp
'. Acne co*edonicus: hidradenitis suppurati3a:
dissectin& cellulites of the scalp
(. Acne con&lo#ata: hidradenitis suppurati3a:
dissectin& cellulites of the scalp
). Show +<plaination
+
CA Child a#use is often incorrectly suspected when
a youn& &irl presents with which cutaneous
6ndin&.
1. Molluscu* conta&iosu*
$. 8ichen sclerosus et atrophicus
%. Condylo*a accu*inata
'. +cchy*oses on face and hands
(. 5enital herpes si*ple<
). Show +<plaination
B
CC ,hich special stain is utili;ed to con6r* the
dia&nosis of 8an&erhans cell histiocytosis.
1. F@+ suTcient for dia&nosis
$. S1!!
%. C0$!
'. C01a
(. Chloroacetate esterase
). Show +<plaination
0
CD Acrokeratosis paraneoplastica is *ost co**only
associated with which of the followin&
*ali&nancies:
1. SLua*ous cell carcino*a
$. Adenocarcino*a
%. /ransitional cell carcino*a
'. /"cell ly*pho*a
(. Breast cancer
). Show +<plaination
A
AA
D! SweetGs syndro*e *ay #e caused #y: 1. Bleo*ycin
$. Cyto<an
%. 5ranulocyte colony sti*ulatin& factor
'. 1ntra3enous i**une &lo#ulin
(. Methotre<ate
). Show +<plaination
C
D1 A patient with in-a**atory #owel disease
de3elops acute tender 4uicy plaLues on the head
and neck: fe3er: and *alaise. /he skin lesions
respond well to prednisone. 0ata shows
increased +SH and neutrophilic in6ltrate with
der*al ede*a on skin #iopsy. ,hich one of the
followin& is a *a4or criteria for this condition.
1. 2e3er and *alaise
$. Fistory of in-a**atory #owel disease
%. A#rupt onset of plaLues
'. 1ncreased +SH
(. 5ood response to prednisone
). Show +<plaination
C
D$ ,hat is the treat*ent of choice for neurotic
e<coriations.
1. Hisperidone
$. 0o<epin
%. 9lan;apine
'. 5a#apentin
(. 0iphenhydra*ine
). Show +<plaination
B
D% Spindle cell lipo*a is co**only found on the: 1. Fead
$. 8ower e<tre*ities
%. Buttocks
'. Breast
(. Posterior shoulder
). Show +<plaination
+
D' A patient with spontaneous occurrence of
petechiae and purpura: particularly around the
eyes: will also *ost likely ha3e which of the
followin&.
1. 0iMuse scalin& of the scalp
$. Acne
%. Cheilits
'. Macro&lossia
(. B3eitis
). Show +<plaination
0
D( A %("year"old *an presents with scattered
in6ltrati3e cutaneous plaLues: chronic fe3er:
parotid &land enlar&e*ent: and a facial ner3e
palsy. ,hat other 6ndin& is *ost likely on
physical e<a*.
1. Anterior u3eitis
$. Periun&ual telan&iectasia
%. Eail pits
'. Eon"scarrin& alopecia
(. Condylo*a lata
). Show +<plaination
A
D) A %( year old *an with a history of celiac
disease presents with a #eefy: red ton&ue:
hyperpi&*ented pal*ar creases: and pre*ature
&rey hair. ,hich of the followin& state*ents are
is correct.
1. /he #est therapy is ri#o-a3in (*&day
$. /his condition *i*ics folate de6ciency
%. 1t is often associated with carcinoid tu*ors
which di3ert tryptophan to serotonin
'. /his condition can #e caused #y a;ithioprine:
("2B: and isonia;id
(. +atin& raw e&& whites is a risk factor
). Show +<plaination
B
DA /he dia&nosis is 1. Psoriasis:
$. Alopecia areata
%. 9nycho*ycosis
'. 8ichen planus
(. /etracycline"induced photo"onycholysis
). Show +<plaination
0
DC 1n lichen planus pe*phi&oides: 1. Bullae de3elop characteristically in lesions of
lon&standin& lichen planus
$. Circulatin& 1&5 anti#odies react to the $%!
k0a anti&en within the #ase*ent *e*#rane
;one
%. /here is &ranular deposition of 1&5 and C% at
the der*oepider*al 4unction
'. Bullae result fro* intense lichenoid
in-a**ation and e<tensi3e liLuefacti3e
de&eneration of #asal keratinocytes
(. ?esicles *ay de3elop de no3o on pre3iously
unin3ol3ed skin
). Show +<plaination
+
DD ,hat is the *ost likely dia&nosis. 1. 0er*ato6#ro*asarco*a protu#erans
$. 0er*ato6#ro*a
%. 8o#o*ycosis
'. Blasto*ycosis
(. Keloid
). Show +<plaination
+
1!
!
,hat is the treat*ent of choice for this patient
who de3eloped acne ful*inans one *onth after
1. Add oral prednisone
$. 1ncrease isotretinoin dose
A
AC
startin& isotretinoin therapy. %. Add do<ycycline
'. Acne sur&ery
(. Check lipid le3els
). Show +<plaination
1!
1
A patient presents with recurrent &enital and
oral ulcerations and a dia&nosis of posterior
u3eitis. ,hat F8A type is associated with the
dia&nosis you suspect.
1. F8A"B$A
$. F8A"B(1
%. F8A"0H%
'. F8A"Cw)
(. F8A"0H'
). Show +<plaination
B
1!
$
,hat is the *ost co**on cause of
erythroder*a in non"F1? patients.
1. 0ru&s
$. Bnderlyin& *ali&nancy
%. Pre"e<istin& der*atoses
'. 1nfection
(. 1diopathic
). Show +<plaination
C
1!
%
+ye#row &rowth: 1. 1s andro&en"dependent in *en #ut not in
wo*en
$. 1s re&ulated #y dehydroepiandrosterone #ut
not androstenedione
%. 1s not andro&en"dependent
'. HeLuires con3ersion of testosterone to
dihydrotestosterone in the hair follicle
(. 1s re&ulated only #y testosterone and
dihydrotestosterone
). Show +<plaination
C
1!
'
,hich of the followin& is a *anifestation of
psoriasis of the nail *atri<.
1. Splinter he*orrha&es
$. J9il spotsJ
%. Su#un&ual hyperkeratosis
'. Pits
(. 9nycholysis
). Show +<plaination
0
1!
(
Conco*itant discoid lupus is found in what
percenta&e of patients with su#acute cutaneous
lupus.
1. (N
$. $!N
%. '!N
'. )!N
(. C!N
). Show +<plaination
B
1!
)
,hich anti#ody is speci6c for CH+S/ syndro*e. 1. Anti"*itochondrial
$. Anti"histone
%. Anti"ds 0EA
'. Anti"nucleolar
(. Anti"centro*ere
). Show +<plaination
+
1!
A
Patients with psoriasis treated with cyclosporine
should #e *onitored for:
1. Sicca sy*pto*s
$. Fyper*a&nese*ia
%. Alopecia
'. Acute interstitial pneu*onitis
(. Fyperkale*ia
). Show +<plaination
+
1!
C
A '("year"old wo*an de3elops #ilateral
poikiloder*atous patches without atrophy on
her lateral thi&hs. /his is *ost likely a
*anifestation of what disease.
1. 8upus +rythe*atosus
$. 0er*ato*yositis
%. Mycosis 2un&oides
'. Fepatitis C
(. 0ia#etes Mellitus
). Show +<plaination
B
1!
D
,hich of the followin& state*ents is true
re&ardin& this entity.
1. C!N of patients with early onset disease
ha3e a positi3e fa*ily history
$. /win concordance =identical twins> is ((N
%. /he inner root sheath and *atri< of nor*al
hair e<press MFC class 1
'. /he sisapho pattern in3ol3es the occipital
scalp
(. Atopic der*atitis is a predictor of &ood
pro&nosis
). Show +<plaination
B
11
!
A $( year"old pre3iously healthy *an presents
with the skin 6ndin&s shown: urethritis: and one
*onth of peripheral arthritis. ,hich of the
followin& is true re&ardin& this condition.
1. 2e*ales and *ales are eLually aMected
$. A chronic defor*in& arthritis occurs in $!N
%. /E2"alpha inhi#itin& a&ents ha3e no role in
the treat*ent of this condition
'. Patients *ust ha3e urethritis: con4uncti3itis:
and arthritis for dia&nosis
B
AD
(. Chla*ydia cer3icitis is not associated with
this condition
). Show +<plaination
11
1
,hich of the followin& disorders is pri*arily
associated with a *onoclonal &a**opathy of
the 1&A type.
1. Sclero*y<ede*a
$. Sclerede*a
%. Eecro#iotic <antho&ranulo*a
'. Schnit;lerGs syndro*e
(. Pyoder*a &an&renosus*
). Show +<plaination
+
11
$
/he *echanis* of action of a;ithro*ycin is: 1. 1nhi#ition of #acterial cell wall synthesis
$. 1nhi#ition of HEA"dependent protein
synthesis #y #indin& to the %!s ri#oso*al
su#unit
%. 1nhi#ition of HEA"dependent protein
synthesis #y #indin& to the (!s ri#oso*al
su#unit
'. 1nhi#ition of 0EA"dependent HEA poly*erase
(. 1nhi#ition of #acterial topoiso*erase
). Show +<plaination
C
11
%
A positi3e AEA with a speckled stainin& pattern
correlates with stainin& of what cellular
co*ponent.
1. Hi#onucleoproteins
$. Eucleolar HEA
%. Eati3e 0EA
'. Kinetochore
(. Fistones
). Show +<plaination
A
11
'
A %( year old *an with plaLue psoriasis well"
controlled with twice daily application of
calcipotriene !.!!(N crea* noticed a -are of his
psoriasis shortly after he started usin& a
prescription *oisturi;er lotion for psoriasis.
,hich is the *ost likely e<planation for the
apparent decreased eTcacy of calcipotriene.
1. /he *oisturi;er i*paired penetration of the
calcipotriene
$. /he *oisturi;er diluted the calcipotriene
%. /he two e3ents are unrelated
'. /he prescription *oisturi;er likely contains
lactic acid.
(. /he decreased eTcacy is due to
tachyphyla<is
). Show +<plaination
0
11
(
/he *ost co**on associated disorder in a
patient with elastosis perforans serpi&inosa is:
1. Marfan syndro*e
$. 0own syndro*e
%. 9steo&enesis i*perfecta
'. +hlers"0anlos syndro*e
(. Hoth*und"/ho*so* syndro*e
). Show +<plaination
B
11
)
8ichen planus pe*phi&oides has #een
associated with an anti&en to which structure.
1. /ype O?11 colla&en
$. Fe*ides*oso*e plaLue
%. 0es*o&lein %
'. 0es*o&lein 1
(. /ype ?11 colla&en
). Show +<plaination
A
11
A
,hich of the followin& cytokines is *ost
characteristic of atopic der*atitis in its chronic
phase.
1. 1nterferon"&a**a
$. 18"'
%. 18"(
'. 18"1!
(. 18"1%
). Show +<plaination
A
11
C
Menopausal -ushin& can #e eMecti3ely treated
with:
1. Eadolol
$. /ryptophan
%. Clonidine
'. 0ana;ol
(. /a*o<ifen
). Show +<plaination
C
11
D
,hich of the followin& hor*ones #ind the
andro&en receptor.
1. 0ehydroepiandrosterone
$. Androstenedione
%. 0ihydrotestosterone
'. 0ehydroepiandrosterone and
dihydrotestosterone
(. 0ehydroepiandrosterone: androstenedione:
and dihydrotestosterone
). Show +<plaination
C
1$
!
Bullous lupus erythe*atosus is *ost co**only
associated with anti#odies to:
1. /ype 1? colla&en
$. 8a*inin (
%. 0es*o&lein 1
'. Plectin
(. /ype ?11 colla&en
+
C!
). Show +<plaination
1$
1
,hich of the followin& co*ple*ent pro6les
would su&&est a dia&osis of hereditary
an&ioede*a =C1 esterase inhi#itor de6ciency>.
1. C$ hi&h and C' hi&h
$. C1 low and C' hi&h
%. C% hi&h and C1"inh decreased
'. CF (! low and C1"inh hi&h
(. C1"inh nor*al: C1 nor*al and C' low
). Show +<plaination
+
1$
$
,hat is the *ost co**on ocular 6ndin& in this
patient with this &ranulo*atous disease.
1. Blepharitis
$. Acute anterior u3eitis
%. Posterior u3eitis
'. Keratoconus
(. Cataracts
). Show +<plaination
B
1$
%
Sou prescri#e do<ycyline to a $$ year"old wo*an
with acne. Sour patient takes an oral
contracepti3e to pre3ent pre&nancy. Sour patient
read in a *a&a;ine that the do<ycycline *ay
decrease the eTcacy of her contracepti3e: and
asks you a#out this. ,hich of the followin&
anti#iotics has #een de6niti3ely shown to reduce
contracepti3e eTcacy.
1. /etracycline
$. Minocycline
%. A;ithro*ycin
'. /MP"SMO
(. Hifa*pin
). Show +<plaination
+
1$
'
1**unolo&ic a#nor*alities in atopic der*atitis
include:
1. 1ncreased C0C /"cell nu*#er and function
$. 1ncreased secretion of 12E"&a**a
%. 0ecreased e<pression of C0$% on B cells and
*onocytes
'. 1ncreased secretion of 18"'
(. Accentuated 0/F response
). Show +<plaination
0
1$
(
,hat or&anis* caused this disease. 1. Micrococcus sedenditaris
$. Candida al#icans
%. Staphylococcus aureus
'. Coryne#acteriu* tenuis
(. Coryne#acteriu* diptheria
). Show +<plaination
A
1$
)
Most co**on association with &enerali;ed
lesions shown in attached i*a&e is
1. Fod&kinGs disease
$. Eon"Fod&kinGs ly*pho*a
%. 5ranulo*atous *ycosis fun&oides
'. F1? infection
(. 0ia#etes *ellitus
). Show +<plaination
+
1$
A
,hich of the followin& is E9/ true re&ardin&
pri*ary cutaneous a*yloidosis.
1. AA is not the protein co*ponent
$. A*yloid is present around #lood 3essels
%. A8 is not the protein co*ponent
'. Eotal&ia paresthetica *ay #e associated with
the *acular for*
(. A*yloid found in #eni&n and *ali&nant
neoplas*s does not represent pri*ary
cutaneous a*yloidosis
). Show +<plaination
B
1$
C
,hich contact aller&en is found in Kra;y &lue. 1. 2or*aldehyde
$. 8anolin alchohol
%. +thyl cyanoacrylate
'. 9ctyl"di*ethyl"pa#a
(. Mercapto#en;othia;ole
). Show +<plaination
C
1$
D
A 'C year old wo*an was recently dia&nosed
with der*ato*yositis. ,hich e<a*ination would
#e *ost i*portant in a work up for *ali&nancy.
1. Breast e<a*
$. Chest <ray
%. /hyroid e<a*
'. Pel3ic e<a*
(. Stool &uiac
). Show +<plaination
0
1%
!
/he diMerential dia&nosis for the attached i*a&e
should include all of the followin&s e<cept
1. Candidiasis
$. 8ichen planus
%. Contact der*atitis
'. 1n3erse psoriasis
(. +rythras*a
). Show +<plaination
+
1%
1
After #ein& treated for se3eral *onths with
do<ycycline: this patient de3elops a &ra*
ne&ati3e folliculitis. ,hat is the ne<t appropriate
therapy.
1. /etracycline
$. Bactri*
%. 1sotretinoin
'. Ceftria<one
(. Cefepi*e
C
C1
). Show +<plaination
1%
$
A '$ year"old wo*an has the 6ndin&s pictured:
as well as erythe*atous patches on the upper
chest and shoulders. Eo HaynaudGs: polyarthritis:
pul*onary: or cardiac in3ol3e*ent is noted.
,hich anti#ody *i&ht you e<pect to #e present
in this patient.
1. Anti"SHB
$. Anti"7o"1
%. Anti"Mi"$
'. Anti"Ku
(. Anti"8a
). Show +<plaination
C
1%
%
Secondary syste*ic a*yloidosis: 1. Classically in3ol3es the ton&ue and
perior#ital skin
$. 1n3ol3es deposition of A8 protein
%. Can in3ol3e deposition of #eta $"
*icro&lo#ulin in the settin& of rheu*atoid
arthritis
'. Can #e noted on #iopsy of nor*al skin
(. 1n3ol3es deposition of keratin"deri3ed
a*yloid
). Show +<plaination
0
1%
'
MA51C syndro*e in3ol3es: 1. Helapsin& polychondritis
$. Acne con&lo#ata
%. 8i3edo reticularis
'. 8ipodystrophy
(. Psoriatic arthritis
). Show +<plaination
A
1%
(
,hat is the dia&nosis. 1. Psoriasis
$. 8ichen planus
%. Balanitis circinata
'. Candida
(. Syphilis
). Show +<plaination
C
1%
)
A patient has aller&ic contact der*atitis to
paraphenylenedia*ine. ,hich of the followin&
aller&ens *ay show a potential cross" reaction.
1. Adhesi3e
$. Sulfa dru&s
%. 8idocaine
'. 2ra&rance
(. Eickel
). Show +<plaination
B
1%
A
A '! year"old *an presents with a co*plaint of
nail chan&es for se3eral years. Fe was treated
#y an outside physician with ter#ina6ne without
i*pro3e*ent. 9n further Luestionin&: he reports
*ornin& shoulder stiMness and #ack pain that
lasts 1"$ hours and i*pro3es with acti3ity. ,hich
of the followin& is true re&ardin& his condition.
1. (!N of patients present with 4oint disease
prior to skin in3ol3e*ent
$. Bony erosions are not co**only seen on
radio&raphs
%. Cyclosporine is eMecti3e in treatin& the
arthritis in this condition
'. A positi3e rheu*atoid factor *ay #e seen
(. 7oint disease correlates with se3erity of skin
in3ol3e*ent
). Show +<plaination
0
1%
C
Oantho*a striata pal*aris are dia&nostic of: 1. 2a*ilial hypertri&lyceride*ia =type 1?>
$. 2a*ilial dys#etalipoproteine*ia =type 111>
%. 2a*ilial lipoprotein lipase de6ciency =AH>
'. 2a*ilial lipoprotein lipase de6ciency =A0>
(. Apoprotein C11 de6ciency
). Show +<plaination
B
1%
D
A patient presents with recurrent crops of
papules that ulcerate and then spontaneously
heal. ,hat i**unohistoche*ical stain would #e
helpful in *akin& the dian&osis.
1. C0 '
$. C0 $!
%. C0 %!
'. C0 ()
(. C0 )C
). Show +<plaination
C
1'
!
Perior#ital purpura is a characteristic cutaneous
*anifestation of:
1. Sarcoidosis
$. A*yloidosis
%. 0er*ato*yositis
'. 8y*pho*a
(. /hro*#ocytopenia
). Show +<plaination
B
1'
1
,hich of the followin& disorders is *ost stron&ly
associated with a *onoclonal &a**opathy of
the 1&5"la*#da type.
1. Sclerede*a
$. P9+MS syndro*e
%. Eecro#iotic <antho&ranulo*a
'. ++0
(. Sclero*y<ede*a
). Show +<plaination
+
1'
$
/he *ost i*portant *ediator of retinoid acti3ity
in the skin is:
1. HAH"alpha
$. HAH"#eta
C
C$
%. HAH"&a**a
'. HOH"alpha
(. HOH"#eta
). Show +<plaination
1'
%
,hich is the *ost co**on site for a#do*inal
carcinoid tu*ors causin& the classic carcinoid
syndro*e.
1. 1leu*
$. Appendi<
%. Hectu*
'. Bronchus
(. 8i3er
). Show +<plaination
B
1'
'
,hat is the *ost co**on paraproteine*ia in
sclero*y<ede*a
1. 1&A
$. 1&5 kappa
%. 1&5 la*#da
'. 1&M
(. 1t is unco**on to see paraproteine*ia with
sclero*y<ede*a
). Show +<plaination
C
1'
(
,hat co*plication can occur if this disease is
left untreated.
1. 0e3elop*ent of a sLua*ous cell carcino*a
$. /esticular torsion
%. +rectile dysfunction
'. 1*potence
(. Pseudo"ainhu*
). Show +<plaination
A
1'
)
/his wo*an is #ein& treated for corticosteroid"
induced rosacea with topical *etronida;ole and
an oral tetracycline. She is 3ery concerned a#out
the redness of her face. 7udicious use of what
color concealer can reduce the appearance of
redness on the skin.
1. Sellow
$. 8a3ender
%. Pink
'. Bron;e
(. 5reen
). Show +<plaination
+
1'
A
An elderly &entle*an with rheu*atoid arthritis
has a $"*onth history of recurrent painful: red:
swollen ears and hearin& loss. Physical e<a* is
nota#le for sparin& of the earlo#es. Sou suspect
he has:
1. Chondroder*atitis nodularis helices
$. Hecurrent otitis e<terna
%. Helapsin& polychondritis
'. Syste*ic lupus erthe*atosus
(. Se3ere se#orrheic der*atitis
). Show +<plaination
C
1'
C
Perifolicular depi&*entation is a characteristic
cutaneous *anifestation of:
1. 0er*ato*yositis
$. Secondary syphilis
%. Scleroder*a
'. 0iscoid lupus
(. Sarcoidosis
). Show +<plaination
C
1'
D
Pyoder*a &an&renosu* is *ost co**only
reported with which *ali&nancy.
1. 8euke*ia
$. Medullary thyroid carcino*a
%. 8un& carcino*a
'. Breast carcino*a
(. Prostate carcino*a
). Show +<plaination
A
1(
!
2irst line therapy for su#corneal pustular
der*atosis is:
1. 0apsone
$. /etracycline
%. ?ita*in +
'. /opical retinoids
(. /opical steroids
). Show +<plaination
A
1(
1
Syndro*e that is associated with disease shown
in i*a&e is known as
1. SAPF9 syndro*e
$. 2ollicular occlusion tetrad syndro*e
%. 8+9PAH0 syndro*e
'. EAM+ syndro*e
(. PAPA syndro*e
). Show +<plaination
+
1(
$
A patient with this cutanous 6ndin& alon& with
peri"ocular erythe*a: deltoid weakness and
pul*onary disease is *ost likely to ha3e which
la#oratory 6ndin&.
1. Anti"7o"1 anti#odies a&ainst histidyl"tHEA
synthetase
$. Anti"7o"1 anti#odies a&ainst nuclear helicase
%. c"AECA a&ainst proteinase"%
'. 8upus anticoa&ulant
(. Anti"histone anti#odies
). Show +<plaination
A
1(
%
,hich of the followin& is associated with this
scarrin& condition.
1. /hyroid disease
$. Acne con&lo#ata
%. Sarcoidosis
'. Syste*ic lupus erythe*atosus
(. 8ichen planus
B
C%
). Show +<plaination
1(
'
Attached i*a&e can #e associated with all of the
followin&s e<cpet:
1. S*ooth *uscle ha*arto*a
$. Bnilateral #reast hypoplasia
%. Acnefor* lesion
'. Skeletal defect
(. Cardiac defect
). Show +<plaination
+
1(
(
Androstenedione is produced #y: 1. /he adrenals
$. /he o3aries
%. /he adrenals and o3aries
'. +<tra&landular con3ersion
(. /he adrenals: o3aries: and e<tra&landular
con3ersion
). Show +<plaination
C
1(
)
Patients with 0er*atitis Ferpetifor*is are *ost
likely to ha3e:
1. Anti#odies to BPA&$
$. Anti#odies to trans&luta*inase %
%. Mutations in trans&luta*inase 1
'. Mutations in la*inin (
(. Mutations in plectin
). Show +<plaination
B
1(
A
/his radio&raph shows a characteristic 6ndin& of
se3ere psoriatic arthritis: #one proliferation at
the #ase of the distal phalan< with resorption of
the tufts. ,hat is the *ost co**on for* of
psoriatic arthritis.
1. Arthritis *utilans
$. A<ial
%. Sy**etric polyarthritis
'. Asy**etric oli&oarthritis
(. Sy**etric oli&oarthritis
). Show +<plaination
0
1(
C
/opical calcineurin inhi#itors *ay oMer se3eral
#ene6ts o3er topical steroids in treatin& the
scaly: licheni6ed perior#ital plaLues in this
patient with atopic der*atitis: includin&:
1. More cost eMecti3e
$. Quicker onset of action
%. 0ecreased irritant potential
'. A#sence of reports of cutaneous atrophy
(. 9nce daily application
). Show +<plaination
0
1(
D
A % year"old &irl has a red"yellow papule on her
cheek which her *other is e<tre*ely an<ious
a#out. Skin #iopsy re3eals a 4u3enile
<antho&ranulo*a. ,hich specialist should you
refer the patient to.
1. Plastic sur&eon
$. +ndocrinolo&ist
%. Eeurolo&ist
'. 9phthal*olo&ist
(. 9ncolo&ist
). Show +<plaination
0
1)
!
A patient presents with he*orrha&ic
onycholysis. /he dru& class *ost co**only
associated with this 6ndin& is:
1. Quinolone anti#iotics
$. Syste*ic retinoids
%. Calcineurin inhi#itors
'. /a<anes
(. /etracyclines
). Show +<plaination
0
1)
1
A %( year"old otherwise healthy *an presents
with *oderate"to"se3ere plaLue psoriasis:
i*pro3ed on cyclosporine. /he patient wei&hs A!
kilo&ra*s and is takin& a dose of %!! *&day.
Fis #aseline creatinine was !.Cc on follow"up
testin& it is 1.1. All other e<a* and la#oratory
para*eters are within nor*al li*its. /he patient
is pleased with his treat*ent and asks to
continue it. ,hich of the followin& is correct.
1. /he patient has e<ceeded the reco**eded
dosa&e of cyclosporine
$. Sou oMer a decrease of the cyclosporine dose
to $$( *&day and close follow"up
%. /he chan&e in creatinine is not si&ni6cant: no
chan&e is needed
'. Cyclosporine rarely has renal to<icity in
youn&: healthy indi3idualsc thus you *ust
work"up other causes of the increased
creatinine
(. /he cyclosporine should #e stopped
i**ediatelyc the patient *ust a3oid
cyclosporine in the future
). Show +<plaination
B
1)
$
,hich of the followin& is true re&ardin& this
dia&nosis.
1. /he protein deposited is deri3ed fro* 1& li&ht
chains: kappa su#type
$. Skin is in3ol3ed in d1!N of cases
%. A diMerent protein is found in skin lesions
associated with a plas*acyto*a
'. Bullae: when present: are su#epider*al
(. 2actor ? de6ciencies are co**only
associated with this entity
). Show +<plaination
0
1)
%
/his (A"year old *ale co*plains of weakness
when cli*#in& the stairs and this clinical
presentation. ,hich cytokine has #een
i*nplicated in the etiolo&y of this condition.
1. 18"1
$. 1l"1!
%. 1nterferon"alpha
'. 1nterferon"&a**a
(. /u*or necrosis factor alpha
+
C'
). Show +<plaination
1)
'
A %$ year old wo*an: now 1$ weeks pre&nant:
presents to your oTce with pruritic scaly
papules and plaLues. A #iopsy re3eals focal
spon&iosis and parakeratosis in *ounds: a
super6cial peri3ascular der*atitis: and
e<tra3asated red #lood cells in the der*is.
,hich of the followin& is true.
1. 1t has #een associated with +B?.
$. /here is often a -are post"partu* and durin&
su#seLuent pre&nancies.
%. /here is no increased incidence in
i**unoco*pro*ised patients.
'. /here is an increased risk of *iscarria&e in
*others who de3eloped pityriasis rosea
within the 6rst $) weeks of their pre&nancy
(. Acyclo3ir *ay #e eMecti3e in this condition
). Show +<plaination
+
1)
(
,hich syste*ic anesthetic can #e safely used in
*astocytosis.
1. 8idocaine
$. Succinylcholine
%. 0"tu#ocurarine
'. /hiopental
(. Propofol
). Show +<plaination
+
1)
)
Phrynoder*a is associated with de6ciency of
which 3ita*in.
1. ?ita*in A
$. ?ita*in B1
%. ?ita*in B)
'. ?ita*in 0
(. ?ita*in K
). Show +<plaination
A
1)
A
,hat type of a*yloid is deposited into the skin
of this pruritic disorder.
1. A*yloid AA
$. A*yloid A8
%. Keratin deri3ed
'. Beta"$ *icro&lo#ulin
(. /ransthyretin
). Show +<plaination
C
1)
C
,hich of the followin& *edications is *ost likely
to induce or e<acer#ate psoriasis in your patient.
1. Fydrochlorothia;ide
$. 8isinopril
%. A*lodipine
'. Metoprolol
(. 0iltia;e*
). Show +<plaination
0
1)
D
/his 1! year"old &irl presents to your oTce.
/hese lesions ha3e #een present for *onths.
She denies any other syste*ic co*plaints. ,hat
will you tell her parents.
1. /hey should e<pect her to &et *ore lesions
in none sun"e<posed areas
$. She is *ore likely to de3elop syste*ic lupus
erythe*atosus than an adult with these
lesions
%. She is less likely than an adult to de3elop
renal disease
'. She is *ore likely than an adult to de3elop
cardio3ascular disease
(. Eo he*atolo&ic la#s are reLuired for
e3aluation
). Show +<plaination
B
1A
!
,hich of the followin&s is true a#out ne3us
ane*icus
1. Bsually occurs in association with 3itili&o
$. 9ccurs *ore freLuently in *en than in
wo*en
%. Most co**only in3ol3es the upper chest
'. Hesults fro* locally decreased 3ascular
reacti3ity to catechola*ines
(. Contains dilated #lood 3essels
). Show +<plaination
C
1A
1
Best treat*ent option for this sta#le type of
3itili&o is
1. Phototherapy with narrow #and B?B
$. +<ci*er laser
%. 9ral prednisone
'. $!N *ono#en;yl ether of hydroLuinone
(. Eitro&en *ustard
). Show +<plaination
0
1A
$
A pre&nant wo*an presents with *ild
in-a**atory acne which is 3ery #otherso*e to
her. ,hich of the followin& is the *ost
appropriate treat*ent option #ased on 20A
classi6cations of *edication in pre&nancy.
1. /opical erythro*ycin#en;oyl pero<ide &el
$. /opical tretinoin
%. /a;arotene !.1N crea*
'. A;elaic acid $!N crea*
(. Bactri*
). Show +<plaination
0
1A
%
Sarcoidosis presentin& as u3eitis: facial ner3e
palsy: fe3er and parotid &land swellin& is
referred to as:
1. FeerfordtGs syndro*e
$. 8of&renGs syndro*e
%. 8upus pernio
'. 0arier"Houssy disease
(. Schau*ann syndro*e
A
C(
). Show +<plaination
1A
'
Carcino*a of which of the followin& has #een
*ost associated with erythe*a &yratu* repens
1. 8un& cancer
$. Breast cancer
%. Colon cancer
'. Prostate cancer
(. Bpper 51 tract cancer
). Show +<plaination
A
1A
(
Sneddon",ilkinson 0isease: 1. Most often occurs in elderly wo*en
$. Harely in3ol3es intertri&inous areas
%. May occur in association with an 1&5
*onoclonal &a**opathy
'. Can #e treated with narrow #and B?B
(. 1s usually an acute: self"li*ited condition
). Show +<plaination
0
1A
)
A youn& wo*an presents with tender:
erythe*atous nodules an the anterior lower
e<tre*ities. ,hich of the followin& would not #e
an appropriate test to consider.
1. /SF
$. +SH
%. AS9
'. 2un&al cultures
(. PP0
). Show +<plaination
A
1A
A
Cutaneous *anifestations of 3ita*in 0
de6ciency include:
1. Alopecia
$. 2ollicular hyperkeratosis
%. +de*a
'. An&ular cheilitis
(. Atrophic &lossitis
). Show +<plaination
A
1A
C
,hich of the followin& der*atoses occurs at the
latest sta&e of pre&nancy.
1. 0arkenin& of ne3i
$. 8inea ni&ra
%. Melas*a
'. Areolar hyperpi&*entation
(. Psoriasis e<acer#ation
). Show +<plaination
B
1A
D
A co**on site for chloracne is the: 1. 9ccipital scalp
$. 2orehead
%. Scrotu*
'. 2orear*s
(. Shoulders
). Show +<plaination
C
1C
!
Acute he*orrha&ic ede*a of childhood often
presents initially with:
1. 2acial ede*a
$. 8aryn&ospas*
%. Acute a#do*en
'. Fe*aturia
(. Fe*atoche;ia
). Show +<plaination
A
1C
1
Eeutrophilic der*atoses en plaLue is often
associated with which of the followin&.
1. 1&A *onoclonal &a**opathy and a #eni&n
course
$. 1&A *onoclonal &a**opathy and a
*ali&nant course
%. Myelo*a and B ly*pho*as and a #eni&n
course
'. 1&5 *onoclonal &a**opathy and a #eni&n
course
(. 1&5 *onoclonal &a**opathy and a
*ali&nant course
). Show +<plaination
A
1C
$
,hich of the followin& is i*portant in the
patho&enesis of acne 3ul&aris.
1. Acti3ation of toll"like receptor"% #y P. acnes
$. Acti3ation of toll"like receptor"$ #y M. furfur
%. Acti3ation of toll"like receptor"$ #y P. acnes
'. P. acnes produces lipase which clea3es
cholesterol into tri&lycerides
(. 0e*ode< acti3ates co*ple*ent
). Show +<plaination
C
1C
%
A %( year"old wo*an presents with
predo*inantly lower facial in-a**atory acne:
hirsutis*: and irre&ular *enses. She has failed
*ultiple con3entional treat*ents. 8a#oratory
work"up re3eals a 3ery hi&h le3el of 0F+A"S. Sou
are *ost concerned a#out:
1. Con&enital adrenal hyperplasia
$. Adrenal tu*or
%. Polycystic o3ary syndro*e
'. /o<icity fro* prolon&ed use of spironolactone
(. Pro&estin e<cess fro* oral contracepti3es
). Show +<plaination
B
1C
'
,hich of the followin& cytokines is associated
with follicular plu&&in& and *icroco*edo
for*ation.
1. 18"'
$. 18"1%
%. /E2"e
0
C)
'. 18"1
(. /52"ooo
). Show +<plaination
1C
(
Acneifor* eruptions ha3e #een associated with
which of the followin& 3ita*ins.
1. ?ita*in C
$. ?ita*in +
%. ?ita*in A
'. Biotin
(. ?ita*in B1$
). Show +<plaination
+
1C
)
9ne of your acne patients has #een treated with
do<ycycline for se3eral *onths and de3elops
culture positi3e &ra* ne&ati3e folliculitis. ,hat
is the ne<t appropriate therapy
1. /etracycline
$. Bactri*
%. 1sotretinoin
'. Ceftria<one
(. Cefepi*e
). Show +<plaination
C
1C
A
,hich of the followin& is a pro&estin used in oral
contracepti3es with low intrinsic andro&enic
properties.
1. Eor&estrel
$. Eorethindrone
%. Eor&esti*ate
'. 8e3onor&estrel
(. Spironolactone
). Show +<plaination
C
1C
C
A youn& &irl presents with recurrent se3ere
arthritis of the ankles. She also has a lar&e ulcer
on her le& and se3ere acne. ,hich &ene is
*utated.
1. PS/P1P1
$. E90$
%. C1AS1
'. A1H+
(. 29OP%
). Show +<plaination
A
1C
D
,hich of the followin& is true re&ardin& Seip"
8awrence Syndro*e.
1. /his condition is acLuired
$. Mentalco&niti3e function is unaMected
%. /hyroid function a#nor*alities cause heat
intolerance
'. Fypertrichosis is often a feature
(. Basic *eta#olic rate is depressed
). Show +<plaination
0
1D
!
1n a well"desi&ned study: the i*pact of psoriasis
on health"related Luality of life was found to #e
si*ilar to which of the followin& conditions.
1. 0ia#etes
$. Acne 3ul&aris
%. 9nycho*ycosis
'. Seasonal aller&ic rhinitis
(. Fypercholesterole*ia
). Show +<plaination
A
1D
1
/he *ost co**on la#oratory a#nor*ality in
patients treated with isotretinoin is:
1. 0ecreased white #lood cell count
$. 1ncreased cholesterol
%. +le3ated li3er en;y*es
'. Fypertri&lyceride*ia
(. +le3ated CPK
). Show +<plaination
0
1D
$
AC+ inhi#itors cause an&ioede*a 3ia sti*ulation
of.
1. Bradykinins
$. Fista*ine
%. Prosta&landins
'. 8eukotrienes
(. Co*ple*ent
). Show +<plaination
A
1D
%
,hat na*e is co**only used to descri#e this
condition of nodular elastosis with cysts and
co*edones.
1. Actinic &ranulo*a
$. Chlorance
%. Cutis rho*#oidalis nuchae
'. Colloid *iliu*
(. 2a3re"Hacouchot
). Show +<plaination
+
1D
'
,hich auto"anti#ody correlates with this 6ndin&:
shawl si&n and an o3erall fa3ora#le pro&nosis in
0er*ato*yositis.
1. Anti"Mi"$ anti#ody
$. Anti"7o"1 anti#ody
%. Anti"SHB anti#ody
'. Anti"KB anti#ody
(. Anti"P8A anti#ody
). Show +<plaination
A
1D
(
A %$ year"old pre&nant wo*an presents for
treat*ent co*edonal and *oderately
in-a**atory acne. Sou discuss treat*ent
options with her: and she asks a#out the
e3idence for safety in pre&nancy of 3arious
treat*ents. Accordin& to the 20A classi6cations:
which of the followin& treat*ents either shows
1. Ben;oyl pero<ide
$. /ri*ethopri*"sulfa*etho<a;ole
%. /opical tretinoin
'. A;eleic acid
(. /etracycline
). Show +<plaination
0
CA
no risk to the fetus in controlled studies =#ut
*ay show risk to ani*als>: or shows no risk in
ani*al studies =#ut no hu*an studies ha3e #een
conducted>.
1D
)
,hat condition does this patient ha3e &i3en the
e<tent of arthritis seen in this O"ray.
1. Antiphospholipid syndro*e
$. Multicentric reticulohistiocytosis
%. Alpha"1"antitrypsin syndro*e
'. +osinophilic fasciitis
(. 0er*ato*yositis
). Show +<plaination
B
1D
A
A pre&nant wo*an presents with the followin&
condition which is #otherso*e to her. ,hich of
the followin& is the *ost appropriate treat*ent
option #ased on 20A classi6cations of
*edication in pre&nancy.
1. /opical erythro*ycin#en;oyl pero<ide &el
$. /opical tretinoin
%. /a;arotene !.1N crea*
'. A;elaic acid $!N crea*
(. Bactri* 0S
). Show +<plaination
0
1D
C
/he presentation of a fore&ut carcinoid tu*or
in3ol3es:
1. /he production of hista*ine: cyanotic -ush:
and #ronchoconstriction
$. /he production of serotonin: intense -ushin&:
peptic ulcer: and lacri*ation
%. /o cutaneous 6ndin&s
'. /he production of kallikrein with #ronchial
asth*a and an&ioede*a
(. 2reLuent episodes of ton&ue swellin& and
urticaria
). Show +<plaination
B
1D
D
,hat is the *a4or constituent of se#aceous
&land lipid.
1. /ri&lyceride
$. ,a< esters
%. SLualene
'. 2ree cholesterol
(. Cholesterol esters
). Show +<plaination
A
$!
!
8eukokeratosis nicotina palati: 1. 1s not attri#uted to s*okin&
$. Hepresents a pre*ali&nant condition
%. Hesponds to intralesional steroids
'. Hepresents in-a*ed *inor sali3ary &lands
(. Hesol3es with tetracycline therapy
). Show +<plaination
0
$!
1
A '! year old wo*en presents to the clinic with
*ultiple pustules in annular and serpi&inous
patterns on the a#do*en: a<illae and &roin.
Fistopatholo&y re3eals pustules #elow the
stratu* corneu* with *any neutrophils and
without any acantholysis. ,hat is the dia&nosis.
1. Sneddon",ilkinson disease
$. HeiterGs syndro*e
%. SAPF9 syndro*e
'. /ransient pustular *elanosis
(. Pthirus pu#is
). Show +<plaination
A
$!
$
,hich of the followin& for*s of an&ioede*a is
*ediated #y kinin release.
1. Fereditary an&ioede*a
$. Acute aller&ic an&ioede*a
%. An&ioede*a associated with urticarial
3asculitis
'. ESA10 an&ioede*a
(. 1nfectious an&ioede*a
). Show +<plaination
A
$!
%
/he 6rst step in the for*ation of a closed
co*edone is:
1. 9#struction of the pilose#aceous duct
$. 1ncreased se#u* production
%. Coloni;ation #y P. acnes
'. 1ncreased hor*onal sti*ulation of the
pilose#aceous unit
(. Clo&&in& of the pore with *ake"up
). Show +<plaination
A
$!
'
1**unohistoche*istry of this disease would
likely show:
1. Peri3ascular 1&A
$. 1&M stainin& of colloid #odies
%. 8inear #and of 1&A at the #ase*ent
*e*#rane
'. 1&M intercellularly
(. 5ranular C% at the #ase*ent *e*#rane
). Show +<plaination
B
$!
(
/he I-a& si&nI is seen in which of the followin&
conditions.
1. psoriasis
$. sarcoidosis
%. hidradenitis suppurati3a
'. kwashiorkor
(. telo&en eRu3iu*
). Show +<plaination
0
$! /he hyperproliferati3e epitheliu* of this *ature 1. K1: K1! C
CC
) psoriasis plaLue is associated with increased
e<pression of which keratin=s>.
$. K(: K1'
%. K): K1)
'. K1A
(. K$e
). Show +<plaination
$!
A
,hich of the followin& is characteristic of lichen
planus pi&*entosus.
1. 8esions are typically hypopi&*ented
$. Most cases present in Caucasians
%. 9ral in3ol3e*ent is patho&no*onic
'. Can occasionally see epider*otropic /"cells
(. /runk is typically spared
). Show +<plaination
0
$!
C
,hat is the treat*ent of choice for this
condition.
1. Eystatin
$. 2lucona;ole
%. Better oral hy&iene
'. Penicillin
(. Acyclo3ir
). Show +<plaination
C
$!
D
A $$ year"old wo*an notes irre&ular *enses and
acne that has #een refractory to se3eral o3er"
the"counter and prescription re&i*ens.
Appropriate initial work"up includes
1. Seru* prolactin le3els
$. $'"hour urine cortisol
%. Seru* free and total testosterone: 8F: 2SF:
androstenedione
'. Seru* free and total testosterone: 8F: 2SF:
0F+A"S
(. Seru* free and total testosterone: 8F: 2SF:
1A"9F: hydro<ylase
). Show +<plaination
0
$1
!
A pre*ature infant who is #ein& weaned oM
#reast *ilk de3elops 3esico#ullous and
ec;e*atous skin lesions and diarrhea. ,hich of
the followin& is not another classic precipitant
for this condition
1. Parenteral nutrition
$. Stress =i.e. infection>
%. 0iets with *ainly cereal &rains
'. 8i3er disease
(. Alcoholis*
). Show +<plaination
0
$1
1
/he dia&nosis is: 1. 9nycho*ycosis
$. /rau*a"induced nail chan&es
%. Chronic paronychia
'. Pseudo*onal infection
(. Psoriasis arthritis
). Show +<plaination
+
$1
$
,hich of the followin& is true re&ardin& relapsin&
polychondritis.
1. 1n3ol3e*ent is often #ilateral
$. Patho&enic anti#odies ha3e not yet #een
identi6ed
%. /he course is chronic: yet *ortality is low
'. Both se<es are eLually aMected
(. Mi&ratory arthral&ias are unco**only seen
). Show +<plaination
0
$1
%
Patients of which F8A type are *ore prone to
dru&"induced lupus erythe*atosus when
e<posed to hydrala;ine.
1. F8A"Cw)
$. F8A"BA
%. F8A"0H%
'. F8A"0H'
(. F8A"B)
). Show +<plaination
0
$1
'
Melanocytes can #e found in all of the followin&
e<cept:
1. Ee3us depi&*entosa
$. /yrosinase positi3e al#inis*
%. Ee3us ane*icus
'. ?itili&o
(. Postin-a**atory hypopi&*entation
). Show +<plaination
0
$1
(
,hich of the followin& is a *anifestation of
psoriasis of the nail *atri<.
1. Splinter he*orrha&es
$. 9il spots
%. Su#un&al hyperkeratosis
'. 9nycholysis
(. Pits
). Show +<plaination
+
$1
)
,hich of the followin& is true re&ardin&
syndro*es associated with a*yloidosis.
1. 2a*ilial *editerranean fe3er in3ol3es A8
protein
$. M+E 11a in3ol3es AA protein
%. /he syndro*e that presents with renal
a*yloidosis: fe3ers: li*# pains: and deafness
in3ol3es AA protein
'. 2a*ilial a*yloidotic polyneuropathy type 1?
in3ol3es *utations in apolipoprotein A"1
(. 2a*ilial a*yloidotic polyneuropathy type 111
C
CD
in3ol3es *utations in &elsolin
). Show +<plaination
$1
A
A healthy (! year old *an presents to your
oTce with % red"#rown indurated plaLues on his
forehead. Biopsy re3eals a focal leukocytoclastic
3asculitis: with a diMuse in6ltration of
neutrophils: eosinophils: and ly*phocytes.
,hich of the followin& is a potential treat*ent
option for this patient.
1. Q"switched ale<andrite laser
$. Pulse dye laser
%. Q"switched ru#y laser
'. Ed:SA5 laser
(. 2reLuency"dou#led Ed:SA5 laser
). Show +<plaination
B
$1
C
,hich of the followin& is true re&ardin& atopic
der*atitis.
1. 93er C!N of aMected indi3iduals present in
the 6rst year of life
$. Eatural *easles infection has #een noted to
i*pro3e atopic der*atitis
%. Most children de3elop worsenin& of atopic
der*atitis if they de3elop asth*a later in
childhood
'. Staphylococcus aureus is found in _$(N of
atopic der*atitis skin lesions
(. 1ncreased e<pression of cathelicidins such as
88 %A has #een noted in atopic der*atitis
). Show +<plaination
B
$1
D
,hich of the followin& *edications would likely
e<acer#ate your patientGs psoriasis.
1. Fydrochlorothia;ide
$. 8isinopril
%. A*lodipine
'. Metroprolol
(. 0iltia;e*
). Show +<plaination
0
$$
!
1n the settin& of the lupus erythe*atosus"
associated co*ple*ent de6ciency syndro*e:
which of the followin& would *ost often #e
o#ser3ed.
1. low C% and C'
$. low C$ and C%
%. low C$ and C'
'. low C$ only
(. low C% only
). Show +<plaination
C
$$
1
,hich &enoder*atosis *ay #e associated with
this plaLue of skin #etween the shoulder #lades
with rippled hyperpi&*ented appearance.
1. Cowden syndro*e
$. Peut;"7e&hers syndro*e
%. 5ardner syndro*e
'. Sipple syndro*e
(. 0yskeratosis Con&entia
). Show +<plaination
0
$$
$
Pyosto*atitis 3e&etans is characteristically
associated with which syste*ic disease.
1. Pe*phi&us 3ul&aris
$. Blcerati3e colitis
%. 8ichen planus
'. 8y*pho*a
(. Hheu*atoid arthritis
). Show +<plaination
B
$$
%
Patients with <antho*a disse*inaturn *ay
de*onstrate:
1. +le3ated seru* #eta lipoproteins
$. Sparin& of the oral *ucosa
%. 1n3ol3e*ent of the pituitary &land
'. Sparin& of the -e<ural areas
(. 1ncreased risk of *ali&nant de&eneration
). Show +<plaination
C
$$
'
/he protein co*ponent of pri*ary cutaneous
a*yloidosis is:
1. SAA protein
$. A8 protein
%. Keratin
'. Colla&en
(. Bp1C!
). Show +<plaination
C
$$
(
,hich i**uno&lo#ulins are seen in type 111
cryo&lo#uline*ia.
1. Monoclonal 1&5 and *onoclonal 1&M
$. Monoclonal 1&5 or *onoclonal 1&M
%. Monoclonal 1&M and polyclonal 1&5
'. Polyclonal 1&M and *onoclonal 1&5
(. Polyclonal 1&M and polyclonal 1&5
). Show +<plaination
+
$$
)
,hat is deposited in the upper der*is in this
condition.
1. AK
$. A8
%. /ransthyretin
'. Beta$"*icro&lo#ulin
(. AA
). Show +<plaination
A
$$
A
/he *ost appropriate treat*ent for the
condition shown is:
1. /opical clinda*ycin 1N lotion
$. /opical *etronida;ole !.A(N &el
%. A;elaic acid $!N crea*
+
D!
'. Salicylic acid $N wash
(. Adapalene !.1N &el
). Show +<plaination
$$
C
Most co**on cause of these tender lesions on
this 1$"year old child is
1. 1n-a**atory #owel disease
$. /u#erculosis
%. f#eta"he*olytic streptococcal infection
'. Sersinia
(. 1nfectious *ononucleosis
). Show +<plaination
C
$$
D
,hat is the *ost co**on 3ariant of *orphea in
children.
1. PlaLue
$. 5enerali;ed
%. Bullous
'. 0eep =*orphea profunda>
(. 8inear
). Show +<plaination
+
$%
!
/he *ost co**on cause of internal
*anifestation of scleroder*a is:
1. +sopha&eal dys*otility
$. Sepsis
%. Pul*onary hypertension
'. Acute renal failure
(. HaynaudGs pheno*enon
). Show +<plaination
A
$%
1
Sarcoidosis presentin& with fe3er: cou&h: 4oint
pains: hilar adenopathy and erythe*a nodosu*
is known as:
1. +rythe*a contusifor*e
$. 8oeRerGs syndro*e
%. 8of&renGs syndro*e
'. 0arier"Houssy sarcoid
(. FeerfordtGs syndro*e
). Show +<plaination
C
$%
$
A youn& *an presents with e<plosi3e onset of
se3ere cystic acne with acute: suppurati3e
nodules and plaLues that ulcerate and for* a
#lackish eschar on the trunk as well as the face.
,hich of the followin& is true re&ardin& this
entity.
1. ,o*en are *ore often aMected than *en
$. P. acnes osteo*yelitis presents with lytic
chan&es on <"rays and #one scans
%. /he sternocla3icular 4oint is often in3ol3ed in
this entity
'. Syste*ic corticosteroids are contraindicated
&i3en risk of sepsis
(. Fi&h"dose isotretinoin *onotherapy is the
treat*ent of choice
). Show +<plaination
C
$%
%
Sou are consulted to e3aluate this patient with
tender: war* plaLues on his shins. ,hat other
physical si&ns should you look for.
1. +<ophthal*os
$. B3eitis
%. /achycardia
'. Clu##in& of the 6n&ers
(. Cou&h
). Show +<plaination
B
$%
'
,hich autoanti#odies are associated with an
increased risk of *ali&nancy in
der*ato*yositis.
1. anti"SHP
$. anti"Mi$
%. Anti"7o1
'. anti"1((1'!
(. anti"P8"A
). Show +<plaination
0
$%
(
Eatural infection with which of the followin&
infectious a&ents has #een shown to *iti&ate
atopic der*atitis.
1. Measles
$. S. aureus
%. ?aricella
'. Hu#ella
(. Co<sackie 3irus
). Show +<plaination
A
$%
)
0iarrhea: 0e*entia and a photosensiti3e
der*atitis are associated with a de6ciency of
which 3ita*in.
1. Eiacin
$. Biotin
%. /hia*ine
'. Hi#o-a3in
(. Pyrido<ine
). Show +<plaination
A
$%
A
/his %( year"old *an presents with the lesions
shown. Fe was treated elsewhere for a diMerent
skin condition. Biopsy of these lesions is likely to
show:
1. 1ncreased stainin& on 2ontana Masson #ut
not Perls stain
$. 1ncreased stainin& on Perls stain #ut not
2ontana Masson
%. 1ncreased stainin& on #oth 2ontana Masson
and Perls stain
'. 1ncreased *elanin at the #asal layer and
within *acropha&es only
(. 2i#rosis and increased *ucin deposition
). Show +<plaination
C
D1
$%
C
/he *ost nota#le histolo&ic diMerence #etween
the oral and cutaneous lesions of lichen planus is
the presence in oral 8P of:
1. Acanthosis
$. Parakeratosis
%. Co*pact orthokeratosis
'. ,ed&e"shaped hyper&ranulosis
(. ?acuolar chan&es at the #asal layer
). Show +<plaination
B
$%
D
Patients with chronic idiopathic urticaria should
a3oid:
1. 8ate< products
$. Alcohol
%. Eickel sulfate
'. J"#lockers
(. aspirin
). Show +<plaination
+
$'
!
Blcerati3e colitis and crohn[s disease are *ost
co**only associated with which of the
followin&:
1. Pyoder*a &an&renosu*
$. +rythe*a ele3atu* diutinu*
%. Sweet[s syndro*e
'. 1&A pe*phi&us
(. Sneddon",ilkinson[s disease
). Show +<plaination
C
$'
1
,hich of the followin& is E9/ associated with
this disease of sy**etric induration caused
*ucin deposition.
1. 0ia#etes *ellitus
$. Streptococcal infection
%. Monoclonal &a**opathy
'. Fepatitis C
(. All of the answers are associated with this
disease
). Show +<plaination
0
$'
$
/he *ain cause of nutritional disease in
de3eloped nations is:
1. Bnusual diets
$. 1n-a**atory #owel disease
%. Mala#sorption syndro*es
'. Alcoholis*
(. Psychiatric illness
). Show +<plaination
0
$'
%
A % *onth old presents with a diMuse
3esiculo#ullous rash with copper colored
*acules on the pal*s and soles. Sou ascertain
fro* the history that his *other had a
nonpainful erosion on her la#ia durin& pre&nancy
which spontaneously resol3ed. ,hat other
sy*pto*s would you e<pect this infant to ha3e.
1. Pseudoparalysis of Parrot
$. Fi&ou*enakis si&n
%. Clutton 4oints
'. Mul#erry *olars
(. Saddle nose defor*ity
). Show +<plaination
A
$'
'
,hich of the followin& is a cause of i**unolo&ic
urticaria.
1. Poly*y<in B
$. A*o<icillin
%. 1#uprofen
'. 9piates
(. /artra;ine
). Show +<plaination
B
$'
(
,hat characteristic #ody would #e found on
histopatholo&y of this disease.
1. Ka*ino
$. Ci3atte
%. Fenderson"Patterson
'. 0ono3an
(. 0utcher
). Show +<plaination
B
$'
)
/he 4oint *ost freLuently aMected in acne
ful*inans is the:
1. +l#ow
$. 1nter3erte#ral
%. 0istal interphalan&eal 4oints of the hand
'. Sternocla3icular
(. Sacroiliac
). Show +<plaination
0
$'
A
A )$ year"old *an with chronic renal failure on
he*odialysis presents with carpal tunnel
syndro*e: #one cysts: and spondyloarthropathy.
A dia&nosis of a*yloidosis is suspected. ,hich
of the followin& is true re&ardin& his *ost likely
dia&nosis.
1. AA a*yloid is likely causati3e
$. A8 a*yloid is likely causati3e
%. #eta $"*icro&lo#ulin is likely causati3e
'. keratin"deri3ed a*yloid is likely causati3e
(. A*yloid P co*ponent will not #e found in
aMected tissues
). Show +<plaination
C
$'
C
/he 0unni&an 3ariant of partial lipodystrophy is
caused #y a *utation in which &ene.
1. A5PA/$
$. Seipin
%. Kinc *etalloproteinase
'. Eeutrophil elastase
(. 8MEA
). Show +<plaination
+
$'
D
/he arthritis of BehcetGs disease is
characteristically:
1. Sy**etric: erosi3e polyarthritis
$. Asy**etric: erosi3e polyarthritis
%. Asy**etric: non"erosi3e polyarthritis
C
D$
'. Asy**etric: erosi3e *onoarthritis
(. Sy**etric: non"erosi3e polyarthritis
). Show +<plaination
$(
!
A patient recently underwent parotid sur&ery
and now reports unilateral -ushin& and sweatin&
around *ealti*e. /he ner3e in4ured in this
syndro*e is a #ranch of the
1. 2acial ner3e
$. Ma<illary ner3e
%. Mandi#ular ner3e
'. Cer3ical ner3e
(. 2rontal ner3e
). Show +<plaination
C
$(
1
Monotherapy for acne with topical anti#iotics is
discoura&ed #ecause of:
1. Slow onset of co*edolytic action
$. Potential for irritation
%. 8ack of anti"in-a**atory action
'. Potential for #acterial resistance
(. Poor patient co*pliance
). Show +<plaination
0
$(
$
,hich of the followin& state*ents is true
re&ardin& Mor#ihanGs 0isease.
1. 1t is often *isdia&nosed as cellulitis
$. 1t presents with #lepharitis: con4uncti3itis:
iritis: and keratitis
%. Fistopatholo&y re3eals perifollicular and
peri3ascular noncaseatin& epithelioid
&ranulo*as
'. 1t occurs around the *outh andor nose and
eyes and *ay #e tri&&ered #y topical steroid
use
(. 1t presents with lar&e coalescent nodules and
con-uent drainin& sinuses occupyin& *ost of
the face
). Show +<plaination
A
$(
%
/he *ost co**on syste*ic *anifestations of
syste*ic sclerosis are:
1. 5astrointestinal
$. Cardio3ascular
%. Pul*onary
'. Henal
(. Eeurolo&ic
). Show +<plaination
A
$(
'
,hich or&anic syste* is least likely to #e
in3ol3ed in the attached i*a&e
1. 8i3er
$. Spleen
%. 5enitourinary
'. 5astrointestinal tract
(. Bone *arrow
). Show +<plaination
C
$(
(
/he constellation of erythe*a nodosu*: #ilateral
hilar ly*phadenopathy: u3eitis: fe3er: and
arthritis in patients with sarcoidosis is known as:
1. 8oeRerGs syndro*e
$. Schnit;lerGs syndro*e
%. 8of&renGs syndro*e
'. FeerfordtGs syndro*e
(. Mikulic;Gs syndro*e
). Show +<plaination
C
$(
)
A 1) year old de3elop*entally nor*al *ale
presents to his pediatrician inter*ittent 3a&ue
epidodes of hand and feet paresthesias and non
speci6c episode of 51 distress. Fe is referred to
you to e3aluate nu*erous punctate to ( sli&htly
3errucous: deep"red to #lue"#lack papules
distri#uted diMusely on his trunk in a #athin& suit
distri#ution. Polari;ation *icroscopy of the
sedi*ent of his urine de*onstrates #irefrin&ent
lipid &lo#ules =ie: renal tu#ular epithelial cells or
cell fra&*ents with lipid inclusions> with the
characteristic Maltese cross con6&uration. Fow
is this disorder inherited.
1. Autoso*al do*inant
$. Autoso*al recessi3e
%. O"linked do*inant
'. O"linked recessi3e
(. Eot an inherited disorder
). Show +<plaination
0
$(
A
,hich of the followin& is not associated with this
condition.
1. Poor oral hy&eine
$. Anti#iotic use
%. A&in&
'. /hrush
(. S*okin&
). Show +<plaination
C
$(
C
Kidney disease in Fenoch"Schonlein Purpura
*ay #e predicted #y:
1. 8i*ited skin in3ol3e*ent
$. Spread of purpura to the upper trunk
%. Syno3ial in3ol3e*ent
'. Bullous lesions
(. 2acial ede*a
). Show +<plaination
B
$( ,hich of the followin& is a feature of SneddonGs 1. ?enous thro*#oses A
D%
D Syndro*e. $. Fepatospleno*e&aly
%. anti"Scl"A! autoanti#odies
'. M. tu#erculosis infection
(. C$ de6ciency
). Show +<plaination
$)
!
All of the followin& are true re&ardin& HeiterGYs
syndro*e e<cept:
1. /he classic clinical triad is urethritis:
con4uncti3itis and arthritis
$. Bsually occurs in youn& wo*en of F8A"B$A
&enotype
%. May #e associated with keratoder*a
#elnnorrha&icu*
'. May #e associated with Chla*ydia
tracho*atis
(. Eails *ay #eco*e thick and #rittle with
hea3y su#un&ual hyperkeratotic deposits
). Show +<plaination
B
$)
1
K3ei*"Silt;#ack test is useful in the dia&nosis of: 1. Scarlet fe3er
$. Sarcoidosis
%. 8eprosy
'. 8eish*aniasis
(. Chancroid
). Show +<plaination
B
$)
$
/his patient was started on isotretinoin #ut failed
to discontinue the tetracycline. Fe is at risk for
what co*plication.
1. Acne ful*inans
$. Pseudotu*or cere#ri
%. 0iarrhea
'. 0epression
(. Myositis
). Show +<plaination
B
$)
%
,hat #acteria is thou&ht to possi#ly play a role
in the patho&enesis of this disease.
1. B. #ur&dorferi
$. F. pylori
%. +. coli
'. S. aureus
(. S. enteritidis
). Show +<plaination
A
$)
'
All of the followin& dru&s ha3e #een reported to
cause rash si*ilar to the attached i*a&e e<cept
1. Fydro<yurea
$. 0"penicilla*ine
%. Statins
'. Phenytoin
(. Captopril
). Show +<plaination
+
$)
(
,hich of the followin& treat*ents for acne
inhi#its HEA"dependent protein synthesis #y
#indin& to the (!s ri#oso*al su#unit.
1. +rythro*ycin
$. /etracycline
%. /ri*ethopri*"sulfa*etho<a;le
'. Ben;oyl pero<ide
(. A;eleic acid
). Show +<plaination
A
$)
)
,hich of followin& *edications *ay increase the
likelihood of pseudotu*or cere#ri in patients
takin& oral isotretinoin.
1. Spironolactone
$. 0apsone
%. A*o<icillin
'. Hifa*pin
(. /etracycline
). Show +<plaination
+
$)
A
A teena&er co*es into your oTce reLuestin&
laser hair re*o3al of her si&ni6cant facial hair.
Before you a&ree to treat her: you order which of
the followin& la#oratory analyses.
1. 2SF and 8F
$. 5lucose and he*o&lo#in A1C
%. 2erritin and /1BC
'. /estosterone and 0F+A"S
(. /SF and /%
). Show +<plaination
0
$)
C
/he condition shown here *ay #e e<acer#ated
#y the inappropriate use of which of the
followin&.
1. Co*edo&enic *ake"up foundation
$. Sunscreens
%. +rythro*ycin $N oint*ent
'. /opical corticosteroids
(. Mineral oil"containin& *oisturi;ers
). Show +<plaination
0
$)
D
,hat is the *ost co**on e<tracutaneous
*anifestation of SweetG Ys syndro*e.
1. Arthral&ias
$. Con4uncti3itis
%. Henal in3ol3e*ent
'. Sterile osteo*yelitis
(. 2e3er
). Show +<plaination
+
$A A potentially dan&erous side eMect of 1. Fypokale*ia B
D'
! spironolactone is: $. Fyperkale*ia
%. Fypercalce*ia
'. Fyponatre*ia
(. Fypernatre*ia
). Show +<plaination
$A
1
,hich of the followin& receptor is the *ost
i*portant *ediator of retinoid acti3ity in the
skin.
1. HAH"&a**a
$. HOH"alpha
%. HOH"&a**a
'. HAH"#eta
(. HOH"#eta
). Show +<plaination
A
$A
$
A youn& *an treated with *inocycline
de3eloped #lue"#lack discoloration with acne
scars at his cheeks. A Perls stain would show:
1. 1ncreased *elanin at the #asal layer of the
epider*is
$. Black stainin& &ranules within *acropha&es
%. Blue stainin& &ranules within *acropha&es
'. JMuddy #rownJ pi&*ent &ranules
(. 5iant *elanoso*es
). Show +<plaination
C
$A
%
+Tcacy of oral contracepti3es is reduced #y co"
ad*inistration with which of the followin& dru&s.
1. Minocycline
$. 0o<ycycline
%. Hifa*pin
'. /MP"SMO
(. All of these answers are correct.
). Show +<plaination
C
$A
'
/he *ost co**on location of
der*ato6#rosarco*a protu#erans is:
1. /runk
$. Fead and neck
%. +<tre*ities
'. Eone of these answers are correct
(. head and neck and e<tre*ities
). Show +<plaination
A
$A
(
,hich of the followin& is associated with
HeiterJs syndro*e:
1. Blcerati3e colitis
$. Multiple sclerosis
%. F8A"Cw)
'. Asy**etric arthritis
(. Perioral der*atitis
). Show +<plaination
0
$A
)
A $C year old pre3iously healthy *an presents
with thick crustin&hyperkeratosis of the pal*s
and soles: urethritis: and one *onth of
peripheral arthritis. ,hat of the followin& is true
re&ardin& his condition
1. 2e*ales and *ales are eLually aMected
$. A chronic defor*in& arthritis occurs in $!N
%. /E2"alpha inhi#itin& a&ents ha3e no role in
the treat*ent of this condition
'. Patients *ust ha3e urethritis: con4uncti3itis:
and arthritis for dia&nosis
(. Cla*ydia cer3icitis is not associated with this
condition
). Show +<plaination
B
$A
A
Al*ost all patients with S8+ ha3e positi3e AEAs.
A patient can ha3e AEA"ne&ati3e S8+ if they only
*ake anti#odies to:
1. ss0EA
$. S*
%. B1HEP
'. Ho
(. ds0EA
). Show +<plaination
A
$A
C
/he *ost co**on associated *ali&nancy with
der*ato*yositis is:
1. Colon carcino*a
$. Fepatocellular carcino*a
%. Henal cell carcino*a
'. +sopha&eal carcino*a
(. 93arian carcino*a
). Show +<plaination
+
$A
D
,hich of the followin& is a function of
Propioni#acteriu* acnes =P. acnes> in
contri#utin& to the patho&enesis of acne.
1. 0ownre&ulation of /8H"$ e<pression
$. 1nhi#ition of co*ple*ent
%. Acti3ation of /8H"$
'. 1nhi#ition of 1l"1
(. Heduction in free fatty acid le3els
). Show +<plaination
C
$C
!
,hich of the followin& are risk factor=s> for post"
transplant C/C8.
1. Henal transplant
$. 8i3er transplant
%. Cyclosporine therapy
'. 2e*ale Se<
(. Henal transplant and Cyclosporine therapy
). Show +<plaination
+
$C
1
,hich of the followin& *edications is E9/
associated with e<acer#atin& or causin& this
eruption.
1. 8ithiu*
$. Prednisone
%. Phenytoin
+
D(
'. 1sonia;id
(. Propranolol
). Show +<plaination
$C
$
A %$ year"old wo*an presents with *oderate
hirsutis*. She has nor*al *enses: nor*al"si;ed
o3aries: no e3idence of tu*ors of the adrenal or
o3ary: and nor*al adrenal function: #ut does
ha3e sli&ht ele3ations of plas*a
androstenedione and testosterone. ,hat is the
*ost likely dia&nosis.
1. Stein"8e3enthal syndro*e
$. Cushin& syndro*e
%. 1diopathic hirsutis*
'. 9ccult 3irili;in& tu*or
(. Krucken#er& tu*or
). Show +<plaination
C
$C
%
A *other #rin&s her ' year old #oy with sil3ery
#lond hair into your oTce and reports that her
childGs hair cannot #e co*#ed -at. Sou notice
that it has a spun"&lass appearance. ,hich of
the followin& is false re&ardin& this condition.
1. Biotin has shown i*pro3e*ent in a few cases
$. /here are usually no syste*ic 6ndin&s
%. 8on&itudinal &roo3in& can #e seen on
electron *icroscopy
'. /he hair a#nor*ality tends to persist with
a&e
(. /he condition is autoso*al do*inant
). Show +<plaination
0
$C
'
Presence of which of the followin&
autoanti#odies is dia&nostic of S8+ and not
reported in patients with other connecti3e tissue
diseases.
1. anti"B1HEP
$. anti"ds0EA
%. anti"Ho
'. anti"8a
(. anti"S*
). Show +<plaination
+
$C
(
2irst line treat*ent of chro*o#lasto*ycosis
includes sur&ery and a *edication with which
*echanis* of action.
1. 1nhi#its sLualene epo<idase
$. 1nhi#its 1'"alpha"de*ethylase
%. 0isrupts *icrotu#ule *itotic spindle
for*ation
'. 1nhi#its sythesis of #eta"1:%"di&lucan and
disrupts cell walls
(. 1nhi#its fun&al cytochro*e P"'(! *ediated
1' alpha"lanosterol de*ethylation
). Show +<plaination
B
$C
)
AcLuired an&ioede*a is characteri;ed #y: 1. 1nheritance
$. 0ecreased le3els of C1
%. Self"li*ited course
'. Association with underlyin& *ali&nancy
(. 1ncreased C1 esterase inhi#itor
). Show +<plaination
0
$C
A
/his patient has si*ilar lesions on his distal
e<tre*ities. ,hich la#oratory test can #e done
in order to *ake a dia&nosis.
1. Fe*o&ra*
$. Alkaline phosphatase
%. Creatinine
'. Potassiu*
(. /SF
). Show +<plaination
B
$C
C
,hich for* of sarcoidosis is associated with
ca*ptodactyly.
1. 8of&renGs syndro*e
$. FeerfordtGs syndro*e
%. 0arier"Houssy
'. Mikulic; syndro*e
(. Blau syndro*e
). Show +<plaination
+
$C
D
,hich F8A is associated with psoriatic arthritis in
diseLuili#riu*: especially if spondylitis is
present.
1. F8A"B1A
$. F8A"B1%
%. F8A"Bw(A
'. F8A"Cw)
(. F8A"B$A
). Show +<plaination
+
$D
!
,hat is the *ost co**on site of e<tracutaneous
in3ol3e*ent in this non"infectious disease.
1. 8un&s
$. +yes
%. Bone Marrow
'. 8i3er
(. Easal *ucosa
). Show +<plaination
A
$D
1
,hat sur&ical dressin& would you use if you
wished to de#ride a wound: reduce pain: and
pro3ide a coolin& eMect.
1. Al&inates
$. 2oa*s
%. Fydrocolloid
'. Fydro&el
(. 2il*s
). Show +<plaination
0
$D
$
Mutations in the M+2? &ene product: pyrin:
produce an autoso*al recessi3e syndro*e
characteri;ed #y recurrent fe3ers: peritonitis:
1. 2a*ilial Mediterranean 2e3er
$. PAPA syndro*e
%. /E2 receptor associated periodic syndro*e
A
D)
pleuritis: arthritis and erysipelas"like erythe*a.
,hich of the followin& syndro*es is descri#ed
a#o3e.
'. Fyper 1&0 syndro*e
(. 2a*ilial cold autoin-a**atory syndro*e
). Show +<plaination
$D
%
Pernio or Chil#lains is an in-a**atory skin
condition which is tri&&ered #y cold: wet: non"
free;in& en3iron*ental conditions. Acral skin has
3iolaceous discoloration acco*panied #y
#urnin& or itchin&. ,hile a3oidance and
pre3ention is #est: the *ost eMecti3e
phar*acolo&ic treat*ent is:
1. Eifedipine
$. Eicotina*ide
%. Pheno<y#en;a*ine
'. PsoralenPB?A
(. Aspirin
). Show +<plaination
A
$D
'
Sou suspect that a patient has acLuired
an&ioede*a. 8e3els of which of the followin&
would you e<pect to #e low.
1. C1L: C%
$. C1L: #radykinin
%. C': C1L
'. #radykinin: C%
(. C': C%
). Show +<plaination
C
$D
(
A %( year old *an has a history of intensely
pruritic papules and 3esicles on the e<tensor
surfaces of his lower e<tre*ities. Anti#odies to
epider*al trans&luta*inase are detected. ,hat
is this patient at risk for de3elopin&.
1. Eon"Fod&kin ly*pho*a
$. Colon cancer
%. 8un& cancer
'. C88
(. +sopha&eal cancer
). Show +<plaination
A
$D
)
,hich of the followin& is true re&ardin& this
entity.
1. /he su#cutaneous 3ariant is *ost co**on in
children
$. A(N of locali;ed lesions are still present $
years after dia&nosis
%. 8ocali;ed lesions often ulcerate and heal with
scarrin&
'. /he perforatin& 3ariant classically in3ol3es
the lower e<tre*ities
(. 0ia#etes is present in the *a4ority of
patients with the &enerali;ed 3ariant
). Show +<plaination
A
$D
A
,hat type of colla&en is o3errepresents in this
lesion.
1. Colla&en 1
$. Colla&en 111
%. Colla&en 1?
'. Colla&en ?
(. Colla&en ?11
). Show +<plaination
B
$D
C
/wenty"nail dystrophy: nail plate splittin& and
ptery&iu* for*ation are nail chan&es seen in:
1. 8ichen Planus
$. 0arierGs disease
%. Psoriasis
'. Scleroder*a
(. 0er*ato*yositis
). Show +<plaination
A
$D
D
A patient de3elops pul*onary 6#rosis:
HaynaudGs pheno*enon and skin chan&es
si*ilar to syste*ic sclerosis. /hese chan&es
resol3e followin& discontinuation of which of the
followin& *edications.
1. Bleo*ycin
$. Penicilla*ine
%. Fydrala;ine
'. Minocycline
(. 1sonia;ide
). Show +<plaination
A
%!
!
/he pri*ary co*ponent of hu*an se#u* is: 1. /ri&lycerides
$. 2ree fatty acids
%. Cera*ides
'. Cholesterol
(. SLualene
). Show +<plaination
A
%!
1
/he *ost co**on non"speci6c cutaneous
*anifestation associated with this disease is:
1. 8eukocytoclastic 3asculitis
$. +rtythe*a *ultifor*e
%. Acne 3ul&aris
'. +rythe*a nodosu*
(. 8ichen planus
). Show +<plaination
0
%!
$
,hat is the #est *uscle to #iopsy in
der*ato*yositis.
1. triceps
$. #iceps
%. Luadriceps
'. &luteus *a<i*us
(. deltoid
). Show +<plaination
A
%!
%
,hich aller&en is the *ost likely cause of this
eyelid der*atitis.
1. Mercapto#en;othia;ole
$. +thyleneurea *ela*ine for*aldehyde
%. +thylenedia*ine dihydrochloride
0
DA
'. /osylona*ide for*aldehyde resin
(. Ben;alkoniu* chloride
). Show +<plaination
%!
'
,hich of the followin& is *ost associated with
pruritus.
1. Purpura annularis telan&iectodes
$. 5ou&erotXagBlu* syndro*e =pi&*ented
purpuric lichenoid der*atitis>
%. 8ichen aureus
'. Scha*#er&hGs disease
(. 0ucas and Kapetanakis pi&*ented purpura
). Show +<plaination
+
%!
(
/he protein co*ponent of nodular a*yloidosis
is:
1. SAA protein
$. A8 protein
%. Keratin
'. Colla&en
(. Bp1C!
). Show +<plaination
B
%!
)
,hat is the *ost co**on presentation of
psoriatic arthritis.
1. Asy**etric oli&o" or polyarthritis
$. Sy**etric polyarthritis
%. Spondylitis =a<ial>
'. 0istal interphalan&eal 4oint =01P> disease
(. Arthritis *utilans
). Show +<plaination
A
%!
A
,hich of the followin& is E9/ a feature
associated with this condition.
1. Accelerated #lanch response
$. ,hite der*ato&raphis*
%. Anterior su#capsular cataracts
'. Keratoconus
(. Pityriasis al#a
). Show +<plaination
A
%!
C
,hich en;y*e can #e a useful ad4unct test to
dia&nose ;inc de6ciency where the seru* ;inc
le3el is nor*al or near nor*al.
1. Kinc sulfatase
$. Alkaline phosphatase
%. AS/
'. A8/
(. Creatinine kinase
). Show +<plaination
B
%!
D
/he #est dia&nosis for this con&enital
*elanopenic lesion without e<tracutaneous
associations is
1. Fypo*elanosis of 1to
$. Se&*ental 3itili&o
%. Ash leaf spots
'. Ee3us ane*icus
(. Ee3us achro*icus
). Show +<plaination
+
%1
!
A patient presents with cutaneous lesions
su&&esti3e of sarcoidosis. Sou consider orderin&
a seru* AC+ le3el to help with the dia&nosis.
,hat is the sensiti3ity and speci6city of
checkin& an ace le3el in this pt.
1. Sensiti3ity: )! Speci6city: C!
$. Sensiti3ity: D! Speci6city: )!
%. Sensiti3ity: D( Speci6city: C!
'. Sensiti3ity: )! Speci6city: )!
(. Sensiti3ity: D! Speci6city: $(
). Show +<plaination
A
%1
1
,hich of the followin& F8A types is associated
with psoriasis and predicts earlier onset and
*ore se3ere disease.
1. F8A"B1%
$. F8A"B1A
%. F8A"Bw(A
'. F8A"Cw)
(. F8A"B$A
). Show +<plaination
B
%1
$
,hich F8A type is *ore co**only associated
with this clinical 6ndin&.
1. F8A"BA
$. F8A"B1(
%. F8A"B$A
'. F8A"B(1
(. F8A"0H'
). Show +<plaination
C
%1
%
,hich of the followin& F8A types is associated
with early onset psoriasis.
1. F8A"B1% or F8A"B1A
$. F8A"B$A
%. F8A"B(A: F8A"Cw): or F8A"0HA
'. F8A"Cw$
(. F8A"0H%
). Show +<plaination
C
%1
'
Eeka*Gs 0isease: 1. 1s &enerally responsi3e to topical and
intralesional steroids
$. Characteristically lacks scale
%. Harely in3ol3es the #uttocks
'. Presents with a reticulate pattern on the
dorsal hands and feet
(. Presents with hypopi&*ented: atrophic
0
DC
lesions on the e<tre*ities
). Show +<plaination
%1
(
/F$ i**une responses: 1. Are associated with cell"*ediated i**unity
$. Produce 18")
%. Produce 12E"&a**a
'. Produce /E2"#eta
(. Produce 18"$
). Show +<plaination
B
%1
)
Phrynoder*a can #e seen in all of the followin&
nutritional de6ciency e<cept
1. ?ita*in A
$. ?ita*in B
%. ?ita*in C
'. ?ita*in 0
(. ?ita*in +
). Show +<plaination
0
%1
A
,hat is the epony* used for this inherited:
con&enital condition.
1. Mei&e disease
$. Milroy disease
%. Proteus syndro*e
'. Klippel"/renaunay syndro*e
(. Stuart"/re3es syndro*e
). Show +<plaination
B
%1
C
,hich of the followin& is correct a#out
eosinophilic folliculitis.
1. painful
$. only seen in adults
%. classi6ed as an A10S"de6nin& illness
'. *ore co**on in fe*ales
(. associated with P. acnes infection of hair
follicles
). Show +<plaination
C
%1
D
Macro&lossia can present in all of the followin&
disorders e<cept
1. Pri*ary syste*ic a*yloidosis
$. 0ownGs syndro*e
%. Mucopolysaccharidoses
'. Cretinis*
(. Behchets disease
). Show +<plaination
+
DD
). Ben&in @ Mali&nant /u*or
# Question Answers An
s
1 ,hich of the followin& is true re&ardin& di&ital FP?"
associated sLua*ous cell cancers.
1. /he rate of *etastasis approaches 1(N.
$. FP?1C is the *ost co**on associated sy#type.
%. Mohs *icro&raphic sur&ery yields a $!N recurrence
rate.
'. ,o*en outnu*#er *en $:1.
(. /hese lesions only occur in association with
i**unosuppression.
C
$ ,hat 3irus is *ost closely associated with these
lesions in this F1? infected patient.
1. Fu*an herpes 3irus $
$. Fu*an herpes 3irus )
%. Fu*an herpes 3irus C
'. Cyto*e&alo3irus
(. +#stein Barr 3irus
C
% All of the followin& are true re&ardin& lenti&o
*ali&na e<cept:
1. Fi&h rates of recurrence
$. 9ccurs *ostly on head and neck
%. Mostly in sun"e<posed areas
'. Mar&ins diTcult to e3aluate
(. Spares oral *ucosa
+
' All of the followin&s can #e used for treate*t of this
condition e<cept
1. Cryotherapy
$. /opical 1*iLui*od (N crea*
%. /opical ("-urouracil
'. /opical retinoids
(. Sur&ical e<cision
+
( /he *ost co**on location of super6cial spreadin&
*elano*a in *en is:
1. 8ower le&s
$. Back
%. Bpper e<tre*ities
'. Fead and neck
(. 0i&its
B
) 9n histolo&ic e<a*ination of the adenocarcino*a of
the perineal area: which of the followin& stains
would E9/ #e positi3e.
1. PAS
$. Mucicar*ine
%. C+A
'. +MA
(. FMB'(
+
A ,hich is the *ost co**on neoplas* in patients
who ha3e had lon&"ter* PB?A therapy.
1. Basal cell carcino*a
$. Atypical 6#ro<antho*a
%. SLua*ous cell carcino*a
'. Cutaneous / cell ly*pho*a
(. Melano*a
C
C ,hich of the followin& are true for the si&n of 8eser"
/relat.
1. 8esions are co**only located on the chest and #ack
$. Classically descri#ed to appear in a JChrist*as treeJ
pattern
%. Bsually associated with internal *ali&nancies
'. +rupti3e nature
(. All of these answers are correct
+
D All of the followin& state*ents are true re&ardin&
an&iosarco*as +OC+P/:
1. /hey occur *ore co**only in Caucasians than in non"
Caucasians
$. Men are *ore often aMected than wo*en
%. /hey are rarely sy*pto*atic
'. Hadiation is usually e*ployed after sur&ical e<cision
(. Cer3ical ly*ph nodes are a co**on site of
*etastases
C
1! Merkel cell carcino*a stains positi3ely for: 1. 8eukocyte co**on anti&en
$. Eeuron speci6c enolase
%. ?i*entin
'. S"1!!
(. Eone of these answers are correct
B
11 /he followin& lesion is the classic presentation of: 1. BCC
$. Merkel cell carcino*a
%. Melano*a
'. C/C8
(. Keratoacantho*a
+
1$ ,hich of the followin& are the *ost relia#le
pro&nostic factors in *ali&nant *elano*a.
1. BreslowJs depth and ulceration
$. BreslowJs depth and Clark le3el
%. Clark le3el and ulceration
'. BreslowJs depth and Clark le3el
(. Eone of these answers are correct
A
1% /he *ucin found in this lesion is produced #y: 1. 2i#ro#lasts
$. Keratinocyte
%. Merkel cells
'. Eail *atri<
(. 9steo#last
A
1' /he incidence of cutaneous sLua*ous cell
carcino*a in or&an transplant recipients is
increased #y how *uch co*pared with the &eneral
population.
1. $ fold
$. ( fold
%. 1! fold
'. $! fold
+
1!!
(. )( fold
1( An elderly *an presents to your oTce with a telan&iectatic: 3iolaceous
1c* do*e"shaped nodule on the neck. Biopsy re3eals lar&e: solid nests of
cells of inter*ediate si;e: with a tra#ecular pattern at the periphery. /hese
cells in3ol3e the der*is and spread into the su#cutaneous fat: #ut spare
the o3erlyin& epider*is. /he cells are round and unifor* in si;e: with a
round to o3al nucleus: s*all nucleoli: and e3enly dispersed chro*atin.
Eu*erous *itotic 6&ures and necrotic areas are seen. Eeuron speci6c
enolase is positi3e. ,hich of the followin& is true re&ardin& this patientGs
dia&nosis.
1. Mohs *icro&raphic sur&ery is
contraindicated in treat*ent of this
lesion
$. ?i*entin and des*in stains *ay
#e positi3e
%. S"1!! stains should #e positi3e
'. /his lesion *ay contain AC/F
(. /he neoplas* should not
contain &astrin
0
1) 1n which of the followin& ethnic &roups is sLua*ous
cell carcino*a the *ost co**on type of skin
cancer.
1. Asian 1ndians
$. Caucasians
%. Fispanics
'. 7apanese
(. Chinese
A
1A /he treat*ent of choice for this lesion shown is: 1. Hadiation therapy
$. 1*iLui*od
%. ( 2lourouracil
'. ,ide e<cision with $c* *ar&ins
(. Mohs sur&ery
+
1C All of the followin& *ay increase the incidence of
SCC: +OC+P/:
1. Sun e<posure
$. 1**unosuppression
%. 1ncreasin& a&e
'. Pro<i*ity to the eLuator
(. All of the followin& *ay increase the incidence of SCC
).
+
1D ,hich of the followin& is a clinical sta&e of
keratoacantho*as.
1. PlaLue
$. Mature
%. Proliferati3e
'. Hesol3in&
(. All of these answers are correct e<cept plaLue
+
$! ,hat is the *ost co**on location for pa&etoid
reticulosis.
1. /runk
$. Fead and neck
%. Fands and feet
'. 2le<ural sites of upper and lower e<tre*ities
(. 5enitals
C
$1 A %! year"old &entle*an presents with *ultiple self
healin& lesions si*ilar to the one pictured. 9ther
fa*ily fa*ilies also ha3e the sa*e disease. ,hat is
the *ost likely dia&nosis.
1. +pider*odysplasia 3errucifor*is
$. 2er&uson"S*ith syndro*e
%. Ee3oid #asal cell carcino*a syndro*e
'. 0yskeratosis con&enita
(. Base< syndro*e
B
$$ ,hich of the followin& is not considered a hi&h"risk
location of SCC:
1. +yelids
$. Eose
%. +ar
'. 8ips
(. Chest
+
$% '! year"old *ale presented with a slow &rowin&
lar&e tu*or on the #ack. /he patient under&oes
wide e<cision with ad4uncti3e che*otherapy. ,hich
of the che*otherapeutic a&ents was used.
1. 1*atini#
$. Cytara#ine
%. 0o<oru#icin
'. ?incristine
(. Cisplatin
A
$' ,hich of the followin& are features of
der*ato6#ro*as: which help diMerentiate it fro*
der*ato6#rosarco*a protu#erans.
1. Co**only located on the e<tre*ities
$. 2actor O111a ne&ati3e
%. 2actor O111a positi3e
'. Co**only located on the trunk
(. Co**only located on the e<tre*ities and factor O111a
positi3e
+
$( /he risk of a *elano*a de3elopin& in a &iant
con&enital *elanocytic ne3us is appro<i*ately:
1. %N
$. )N
%. 1$N
'. (!N
(. ?irtually all of these patients will de3elop *elano*a
B
$) A patient with *ultiple skin nodules has a #iopsy
su&&esti3e of cutaneous ly*pho*a. /he ne<t
appropriate step in *akin& the dia&nosis is:
1. Poly*erase chain reaction
$. Co*plete #lood count
%. 2low cyto*etry
'. 1**unohistoche*ical stains
(. Chest <ray
A
$A An elderly white *an presents with a slowly enlar&in&: well"de*arcated
pink: scaly plaLue on the neck. Biopsy of the lesion re3eals epider*al
dysplasia and keratinocytic disor&ani;ation with preser3ation of the
#ase*ent *e*#rane. Fyperkeratosis and parakeratosis are also present:
and nu*erous atypical keratinocytes are seen throu&hout the epider*is:
with loss of polarity: atypia: and *itoses. A chronic in-a**atory
in6ltrate is present in the upper der*is. ,hich of the followin&
treat*ent=s> should #e considered for this patient.
1. Con3entional e<cision
$. Mohs *icro&raphic sur&ery
%. 1*iLui*od
'. Con3entional e<cision and Mohs
*icro&raphic sur&ery
(. All of these answers are correct
+
$C 1nter*ittent sun e<posure with painful sun#urns is a
predisposin& factor for the de3elop*ent of:
1. Atypical ne3i
$. Se#orrheic keratosis
%. Mali&nant *elano*a
'. Atypical ne3i and Mali&nant *elano*a
(. All of these answers are correct
0
$D /he cure rate of cryotherapy as a treat*ent for
actinic keratoses is:
1. C!N
$. C(N
%. D!N
'. D(N
(. DDN
+
1!1
%! Co*pared with the &eneral population: what is the
o3erall risk of de3elopin& cutaneous and syste*ic
*ali&nancies in or&an transplant recipient.
1. ' fold
$. 1! fold
%. $( fold
'. (! fold
(. 1!! fold
A
%1 ,hat would #e the characteristic histopatholo&ic
6ndin&s of this lesion.
1. 2ull thickness keratinocytic atypia
$. Cornoid la*ella
%. Pale stainin& cells
'. Forn pseudocysts
(. ,ed&e shaped &ranular layer with lichenoid in6ltrate
B
%$ /he *ost co**on location for pri*ary *ucinous
carcino*a is:
1. neck
$. eyelid
%. areola
'. scrotu*
(. nose
B
%% Co**only used i**unohistoche*ical *arkers that
are positi3e in Merkel cell carcino*as include all of
the followin& +OC+P/:
1. Chro*o&ranin AB
$. Synaptophysin
%. 5lial 6#rillary acidic protein
'. Cytokeratin $!
(. Cytokeratin C
C
%' /he Pinkus BCC is freLuently located on the: 1. 0i&its
$. +yelid
%. 8ips
'. +ar
(. 8u*#osacral area
+
%( /he *ost i*portant *utated &ene associated with a
predisposition to de3elop *ali&nant *elano*a is:
1. P/CF
$. C0KE$A
%. P/CF$
'. Eone of these answers are correct
(. All of these answers are correct
B
%) ,hat te*perature *ust #e achie3ed for adeLuate
treat*ent of a s*all super6cial sLua*ous cell
carcino*a with cryotherapy.
1. "1! de&rees Celcius
$. "$! de&rees Celcius
%. "%! de&rees Celcius
'. "'! de&rees Celcius
(. "(! de&rees Celcius
+
%A 0enileukin diftito< =9E/AKJ>: 1. is a syste*ic treat*ent option for C/C8
$. is a diphtheria fusion to<in
%. tar&ets the interleukin"$ receptor
'. Eone of these answers are correct
(. All of these answers are correct
+
%C /he 5r;y#owski type of keratoacantho*a: 1. 1s characteri;ed #y rapid &rowth of a sin&le lesion
reachin& a dia*eter of D c* or *ore
$. /ypically in3ades underlyin& cartila&e
%. 0e*onstrates si*ultaneous central healin&
'. Presents in childhood on sun"e<posed surfaces
(. Presents with hundreds of disse*inated lesions
+
%D 0es*oplastic trichoepithelio*a: 1. 1s *ost co**on in *iddle"a&ed patients
$. More co**only appears in *ales than in fe*ales
%. 0oes not display foci of calci6cation or ossi6cation
'. Presents as a well"circu*scri#ed lesions located in the
upper der*is
(. Eone of these answers are correct
0
'! Se3enty"63e year old: *ale patient: with a %c*s
pink: pearly nodule on his chest. Sou notice that the
patient has a scar on the sa*e area. /he treat*ent
of choice is:
1. Hadiation
$. Con3entional e<cision
%. Cryotherapy
'. Mohs sur&ery
(. 1*iLui*od
0
'1 ,hat is the epony* for this *etastasis to the
u*#ilicus.
1. /ripe pal*
$. Si&n of 8eser"/relat
%. Pityriasis rotunda
'. /rousseau syndro*e
(. Sister Mary 7oseph Eodule
+
'$ ,hich of the followin& is the *ost co**on initial
site of *etastasis fro* a pri*ary BCC.
1. 8un&s
$. He&ional ly*ph nodes
%. Bone
'. 8i3er
(. Pleura
B
'% A youn& wo*an presents with a sin&le s*all: 6r*:
u*#ilicated papule on the face. Biopsy re3eals a
well"circu*scri#ed lesion located in the upper
der*is. Strands of #asaloid cells are seen
surrounded #y 6#rotic or des*oplastic stro*a. Forn
cysts and foci of se#aceous cells and calci6cation
are also noted. Fow should this patient and her
lesion #e treated.
1. Heassurance and no further treat*ent
$. Close clinical follow"up
%. /opical ("-uorouracil
'. Cryotherapy
(. 8ocal sur&ical e<cision
+
'' ,hich of the followin& is an i**unhistoche*ical
*arker for Merkel Cell Carcino*a.:
1. S"1!!
$. ?i*entin
%. FMB"'(
'. Eeuron speci6c enolase
(. All of these answers are correct
0
'( ,hich of the followin& i**unolo&ic dru&s has #een
shown to increase sur3i3al of patients with sta&e 111
and sta&e 1? *elano*a.
1. +tanercept
$. Adali*u*a#
%. Bstekinu*a#
'. 1pili*u*a#
(. 1n-i<i*a#
0
') ,hat is the *ost location for this lesion which lacks 1. Back C
1!$
phosphorylase in the epider*al cells. $. Buttock
%. 8e&
'. Eeck
(. Sacru*
'A A (! year"old fe*ale patient presents with a reddish indurated
plaLue located on her ri&ht cla3icular area =see i*a&e>. /he
#iopsy shows the presence of *ono*orphic spindle cells in a
storifor* pattern: and deep su#cutaneous in6ltration. Accordin&
to the afore*entioned infor*ation: the *ost likely dia&nosis is:
1. Microcystic adne<al carcino*a
$. Se#orrheic keratosis
%. 0er*ato6#rosarco*a protu#erans
'. Merkel cell carcino*a
(. Eone of these answers are correct
C
'C /he *ost co**on site for intra oral *elano*a is. 1. #uccal
$. soft palate
%. hard palate
'. &in&i3a
(. u3ula
C
'D ,hich of the followin& is true re&ardin& actinic
keratoses.
1. Salicylic acid: tretinoin: and alpha"hydro<y acids are
not useful in treat*ent
$. 8ow fat diets *ay decrease the incidence of AKs
%. Cure rates for treat*ent with topical ("-uorouracil are
hi&her than for treat*ent with cryotherapy
'. B?A fro* sunli&ht is *ost responsi#le for AK
de3elop*ent
(. Male &ender is not a risk factor for AKs.
B
(! ,hat is the *ean ti*e"fra*e for de3elop*ent of
Stewart"/re3es Syndro*e.
1. 8ess than 1 year
$. 1 year
%. ( years
'. 1! years
(. `$! years
+
(1 Fistolo&ically: this lesion is shows plu*p: poly&onal
cells arran&ed in nests and fascicles with &ranular
cytoplas*. ,hich i**unohistoche*ical stain would
#e positi3e.
1. Colloidal iron
$. ?on kossa
%. ,arthin"starry
'. S"1!!
(. C0)C
0
($ ,hat is the *ost co**on location of oral SCC. 1. Soft palate
$. Buccal *ucosa
%. 5in&i3a
'. 0orsal ton&ue
(. 8ateral ton&ue
+
(% ,hich phase of the cell cycle does p(% re&ulate. 1. 51
$. 5$
%. S phase
'. Mitosis
(. Meiosis
A
(' All of the followin& state*ents re&ardin& BowenGs
disease are true +OC+P/:
1. 8esions arisin& on the lower li*#s are *ore co**on in
*en than in wo*en
$. /he #ase*ent *e*#rane re*ains intact on
histopatholo&y
%. (N of patients with BowenGs disease de3elop in3asi3e
sLua*ous cell carcino*a
'. Chronic sun e<posure is a risk factor for BowenGs
disease
(. Mucosal BowenGs disease *ay appear as a 3errucous
plaLue
A
(( A (( year"old fe*ale presents with an ulcerated
*ali&nant *elano*a with Breslow dept of 1.(**.
Sentinel ly*ph node #iopsy is ne&ati3e. ,hich of
the followin& is the correct sta&in& classi6cation.
1. Sta&e 1B
$. Sta&e 11A
%. Sta&e 11B
'. Sta&e 111A
(. Sta&e 111B
B
() 0er*oscopic features su&&esti3e of *ali&nant
*elano*a include:
1. Presence of $ or *ore colors within the lesion
$. Blue"whitish 3eil
%. Asy**etric radial strea*in&
'. A#rupt interruption of pi&*ent network in the
periphery
(. All of these answers are correct
+
(A ,hich su#stance does p(% nor*ally acti3ate to
pro*ote apoptosis 3ia inhi#ition of #cl"$.
1. p$1
$. p1)
%. Pu*a
'. Md*$
(. Akt
C
(C A )( year"old fe*ale with *ultiple actinic keratosis
on the face under treat*ent with ("2B. Accordin& to
the i*a&e and afore*entioned infor*ation: you
*ay conclude that:
1. /he patient *ust i**ediately stop treat*ent since
une<pected side eMects ha3e de3eloped
$. /he patient has #een co*pliant with ("2B treat*ent
and the appearance of in-a**ation: erythe*a and erosions
are e<pected
%. /he i*a&e is not rele3ant to ("2B treat*ent
'. Eone of these answers are correct
(. All of these answers are correct
B
(D ,hich of the followin& features of thin *elano*as
=d1 ** thick> has #een associated with an
increased risk of *etastasis.
1. He&ression
$. 8ocation
%. Si;e of lesion
'. 5ender
(. P(% e<pression
A
)! /he risk of *etastasis fro* SCC increases with: 1. /u*or si;e
$. 0epth of in3asion
%. 0e&ree of diMerentiation
'. 1**unosupression
(. All of these answers are correct
+
1!%
)1 ,hich of the followin& is a co**on location of
*elano*a in wo*en.
1. Chest
$. 8ower le&s
%. 5enitals
'. 0i&its
(. Scalp
B
)$ Sentinel ly*ph node #iopsy in *ali&nant *elano*a: 1. Fas &ained acceptance for the treat*ent of MM of
inter*ediate thickness =1"'**>
$. 1s *ainly #ein& used for a *ore accurate sta&in&
%. 1s not reco**ended
'. Eone of these answers are correct
(. Fas &ained acceptance for the treat*ent of MM of
inter*ediate thickness =1"'**> and is *ainly #ein& used for a
*ore accurate sta&in&
+
)% /he keratoacantho*a 3ariant characteri;ed #y the
sudden appearance durin& childhood or adolescence
of *ultiple KAs is called:
1. 5orlin syndro*e
$. Oeroder*a pi&*entosa
%. 2er&uson"S*ith
'. 5r;y#owski
(. Eone of these answers are correct
C
)' A '! year"old fe*ale patient presents with the
followin& lesion =see i*a&e>. /he #iopsy report
shows duct like structures: tadpole structures within
a 6#rotic stro*a. Accordin& to the afore*entioned
infor*ation: the *ost likely dia&nosis is:
1. Microcystic adne<al carcino*a
$. Se#orrheic keratosis
%. 0er*ato6#rosarco*a protu#erans
'. Merkel cell carcino*a
(. Eone of these answers are correct
A
)( Mutations of the p(% &ene has #een associated with
the de3elop*ent of:
1. M*elano*a
$. KaposiJs sarco*a
%. Actinic keratosis
'. Molluscu* conta&iosu*
(. All of these answers are correct
C
)) ,hich test should #e used to detect *onoclonal
&ene rearran&e*ents in cutaneous /"cell
ly*pho*a.
1. Eorthern #lot
$. Southern #lot
%. ,estern #lot
'. +81SA
(. +lectrophoresis
B
)A ,hich of the followin& is *ost likely to present with
cutaneous *etastases in *en.
1. 8un& cancer
$. Colon cancer
%. Prostate cancer
'. Melano*a
(. +sopha&eal Cancer
0
)C ,hen perfor*in& a #iopsy of a suspected
keratoacantho*a:
1. 2usifor* incision throu&h the entire KA *ay #e
perfor*ed
$. 1t is necessary to #iopsy down to su#cutaneous fat
%. A full"thickness sha3e #iopsy is accepta#le
'. A co*plete e<cisional #iopsy *ay #e perfor*ed
(. All of these answers are correct
+
)D At what location is this tu*or 8+AS/ likely to recur
after sur&ical e<cision.
1. Easola#ial fold
$. 8ateral canthus
%. Mid forehead
'. Preauricular
(. Scalp
C
A! Knowin& that the patient in this picture has a #iopsy
con6r*ed BCC: which of the followin& would #e the
treat*ent of choice:
1. Con3entional e<cision
$. 1*iLui*od
%. Hadiation
'. Mohs *icro&raphic sur&ery
(. Cryosur&ery
).
0
A1 ,hich of the followin& *elano*a su#types is *ore
consistently seen in dark"skinned indi3iduals.
1. Acral lenti&inous *elano*a
$. Super6cial spreadin& *elano*a
%. 8enti&o *ali&na *elano*a
'. Eodular *elano*a
(. Super6cial spreadin& *elano*a and 8enti&o *ali&na
*elano*a
A
A$ ,hich one of the followin& *ali&nancies is
associated with FP? infection.
1. ?errucous carcino*a
$. Metastatic *elano*a
%. Basal cell carcino*a
'. Se#aceous carcino*a
(. Atypical 6#ro<antho*a
A
A% ,hich of the followin& is co**ony seen in
se#orrheic keratoses when e<a*ined with
der*oscopy.
1. Maroon la&oons
$. Eetwork
%. Pi&*ent &lo#ules
'. Milia like cysts
(. Blue"&ray 3eil
0
A' ,hich one of the followin& a&ents has de*onstrated
potential #ene6t as a che*opre3enti3e to B?"
induced skin cancer.
1. Prosta&landin +$
$. ?ita*in 0
%. Arachidonic acid
'. Celeco<i#
(. ?ita*in +
0
A( /he *ost co**on location for an&iosarco*a is: 1. 8e&s
$. Ar*s
%. Fead and neck
'. /runk
(. 0i&its
C
A) A ()"year old wo*an with a history si&ni6cant for
chronic ly*phede*a after radical *astecto*y
twel3e years a&o presents with this &rowth on her
ar*. ,hat is the dia&nosis.
1. An&iosarco*a
$. Bacillary an&io*atosis
%. Castle*anGs syndro*e
'. KaposiGs sarco*a
(. Metastatic #reast carcino*a
A
1!'
AA ,hich of the followin& *elano*a scenarios ha3e
the #est pro&nosis.
1. /wenty"one year old fe*ale with pri*ary lesion located
on the ri&ht lower le&
$. /wenty"one year old *ale with pri*ary lesion located
on the chest
%. /hirty"si< year old *ale with pri*ary lesion located on
the #ack
'. /wenty"one year old fe*ale with pri*ary: ulcerated
lesion located on the ri&ht lower le&
(. /hirty"si< year old *ale with pri*ary lesion located on
his left lower le& with palpa#le in&uinal ly*ph nodes
A
AC Ba;e< syndro*e can #e diMerentiated clinically fro*
Ho*#o syndro*e #y presence of
1. Multiple #asal cell carcino*as
$. /richiepithelio*as
%. Milia
'. Bollicular atrophoder*a
(. Fypohidrosis
+
AD 1f left untreated: which of the followin& is not at risk
for *ali&nant transfor*ation.
1. Bowenoid papulosis
$. Cutaneous horn
%. Actinic cheilitis
'. 8eukoplakia
(. Stucco keratosis
+
C! ,hat kind of /"ly*phocyte is the *ost co**on
neoplastic cell in Cutaneous /"Cell 8y*pho*a:
1. C0'
$. C0C
%. Eatural killer
'. Eone of these answers are correct
(. All of these answers are correct
A
C1 All of the followin& state*ents re&ardin& the patient
pictured are true +OC+P/:
1. Spina #i6da *ay #e an associated 6ndin&
$. /he patient likely has a *utation in the P/CF &ene
%. A*elo#lasto*a is a tu*or associated with this disease
'. /his patient likely had a si*ilarly aMected parent
(. /hese lesions appeared in childhood
C
C$ A patient has a *ali&nant *elano*a 1.)** thick
with ulceration and a *icro*etastasis in 1 node.
/he patientGs sta&in& accordin& to the A*erican
7oint Co**ittee on Cancer Sta&in& Syste* is:
1. 11C
$. 111A
%. 111B
'. 111C
(. 1?
C
C% ,hat is the *ost co**on location for an epitheloid
sarco*a.
1. head and neck
$. pro<i*al e<tre*ities
%. hands and forear*s
'. lower le&s
(. &roin and #uttocks
C
C' Mutations in which &ene would likely #e found in the
neoplastic cells of this lesion.
1. PA/CF
$. p(%
%. 2u*arate hydratase
'. CH+BBP
(. p)%
B
C( ,hich of the followin& is the *ost i*portant
pro&nostic indicator in a patient with cutaneous
ly*pho*a.
1. A&e
$. Pri*ary 3s secondary cutaneous
%. 5ender
'. +<tent of cutaneous in3ol3e*ent
(. Su#type of ly*pho*a
B
C) /he patient is a '( year old *ale co*plainin& of red:
chapped lower lip. ,hich of the followin& lasers is
the *ost appropriate to treat this condition.
1. Pulsed 0ye 8aser
$. Ed:SA5 laser
%. C9$ laser
'. 0iode laser
(. 8aser treat*ent is not an option
C
CA ,hat is the *ost co**on site of *etastasis for this
der*al tu*or.
1. 8un&
$. Brain
%. Kidney
'. 8i3er
(. Bone
A
CC ,hich of the followin& state*ents re&ardin&
pro&nosis for *ali&nant *elano*a is true.
1. 1ncreasin& a&e has a positi3e eMect on sur3i3al.
$. Patients with pri*ary lesions located on the
e<tre*ities =e<cept acral lesions> ha3e a worse pro&nosis than
those with tu*ors located on the trunk.
%. /here is a hi&her sur3i3al rate for patients with
palpa#le *etastatic nodes co*pared to those with
*icro*etastatic nodal disease.
'. 2or sta&e 1? disease: patients with non"3isceral
*etastases =e& skin: su#cutis: distant ly*ph nodes> ha3e a
#etter pro&nosis co*pared with those with 3isceral
*etastases.
(. Male &ender has a positi3e eMect on sur3i3al.
0
CD ,hich of the followin& are features of *icrocystic
adne<al carcino*a that help distin&uish it fro*
des*oplastic trichoepithelio*as.
1. 0eep su#cutaneous in6ltration
$. Perineural in3asion
%. C+A positi3e stainin&
'. Co**only located on the face
(. 0eep su#cutaneous in6ltration:perineural in3asion:
and C+A positi3e stainin&
+
D! ,hich of the followin& neoplas*s has de*onstrated
an association with F/8?"1 infection.
1. Mycosis fun&oides
$. Adult / cell ly*pho*a
%. 2ollicular ly*pho*a
'. Multiple *yelo*a
(. Fod&kinJs disease
B
D1 Chloro*a is a characteristic cutaneous
*anifestation of:
1. /u#erous sclerosis
$. SweetJs syndro*e
%. Eeuro6#ro*atosis
0
1!(
'. 8euke*ia
(. Pseudo*onas sepsis
D$ ,hat is the dia&nosis. 1. Condylo*a acu*inata
$. Molloscu* conta&iosu*
%. Pearly penile papules
'. 8ichen planus
(. Psoriasis
C
D% Periun&ual SLua*ous cell carcino*a has #een
linked to which FP? type=s>.
1. ): 11
$. $: '
%. 1)
'. 1%
(. C
C
D' ,hat would you e<pect to see under der*oscopy of
this 3ascular neoplas*.
1. Hed sacculae
$. Ar#ori;in& #lood 3essels
%. Fair pin telan&ectasia
'. Milky red &lo#ules
(. Blue"&rey o3oid nests
A
D( ,hich FP? serotype has #een associated with
periun&ual SCC.
1. )
$. 1)
%. 11
'. All of these answers are correct
(. FP? is not associated with SCC
B
D) /he 5orlin syndro*e is characteri;ed #y: 1. Multiple BCCs durin& childhood
$. Macrocephaly
%. 9donto&enic keratocysts of the 4aw
'. Autoso*al"recessi3e inheritance pattern
(. All of these answers are correct e<cept Autoso*al"
recessi3e inheritance pattern
+
DA 1**unohistoche*istry of der*ato6#rosarco*a
protu#erans typically re3eals:
1. C0%' ne&ati3e and factor O111a positi3e
$. C0%' ne&ati3e and factor O111a ne&ati3e
%. C0%' positi3e and factor O111a positi3e
'. C0%' positi3e and factor O111a ne&ati3e
(. Eone of these answers are correct
0
DC /he *ost co**on locations of *icrocystic adne<al
carcino*a include all of the followin&: e<cept:
1. Perioral
$. Easola#ial
%. /runk
'. Perior#ital
(. Perioral:nasola#ial: and perior#ital
C
DD Maple leaf"like structures seen on der*oscopy are
characteristic of which lesion.
1. Se#orrheic keratoses
$. Pi&*ented #asal cell carcino*a
%. 0er*al ne3i
'. Melano*a
(. Fe*an&io*a
B
1!
!
/opical ("2luorouracil: 1. 1nterferes with the synthesis of 0EA and HEA
$. 1s an alternati3e for the treat*ent of actinic keratosis
%. May cause pruritus and #urnin& at the site of
application
'. All of these answers are correct
(. Eone of these answers are correct
).
0
1!
1
B?B induced *utations on the P/CF &ene is
associated with the de3elop*ent of:
1. BCC
$. Merkel cell carcino*a
%. An&iosarco*a
'. BCC and Merkel cell carcino*a
(. Merkel cell carcino*a and An&iosarco*a
).
A
1!
$
Mohs *icro&raphic sur&ery the treat*ent of choice
for all of the followin&: e<cept:
1. 1 c* SCC located on the chest
$. $ c*s BCC on lower e<tre*ities
%. 1 c* BCC on the eyelid
'. Morpheafor* BCC on the cheek
(. Hecurrent BCC on the chest
A
1!
%
Fistopatholo&ical e3idence of epider*otropis* *ay
#e seen in which of the followin& conditions:
1. Merkel cell carcino*a
$. SCC
%. C/C8
'. Eone of these answers are correct
(. All of these answers are correct
C
1!
'
Currently: the sur&ical *ar&in for *elano*as that
*easure less than $ ** in thickness is:
1. 1 **
$. !.( c*
%. 1 c*
'. $ c*s
(. % c*s
C
1!
(
,hich of the followin& i**unohistoche*istry
*arker is ne&ati3e in an&iosarco*as.
1. C0%1
$. C+A
%. Cytokeratin
'. C0%'
(. 2actor ?111
B
1!
)
/he hu*an papillo*a 3irus type associated with red
#rown s*ooth and warty papules is
1. FP? 1
$. FP? (
%. FP? A
'. FP? 1%
(. FP? 1)
+
1!
A
All of the followin& disorders *ay *anifest as
e<foliati3e der*atitis e<cept
1. Behchets disease
$. Psoriasis
%. Pe*phi&us foliaceus
'. 0ru& reaction
A
1!)
(. Se;ary syndro*e
1!
C
0er*oscopy would #e the least helpful in e3aluatin&
with lesion.
1. Pi&*ented #asal cell carcino*a
$. Con&enital *elanocytic ner3us
%. Se#orrheic keratosis
'. A*elanotic *elano*a
(. Fe*an&io*a
0
1!
D
/his tu*or: also called a Sha&reen patch: is
characteristic of which of the followin&
&enoder*atoses.
1. Eeuro6#ro*atosis"1
$. Eeuro6#ro*atosis"$
%. /u#erous sclerosis
'. EAM+ syndro*e
(. Buschke"9llendorf
C
11
!
Keratoacantho*as ha3e #een linked etiolo&ically to: 1. Bltra3iolet e<posure
$. Fu*an papillo*a 3irus
%. Che*ical carcino&ens such as tar and pitch
'. S*okin&
(. All of these answers are correct
+
11
1
A*pli6cation of which of the followin& &enes is
associated with Merkel cell carcino*a.
1. 8"Myc
$. C"Myc
%. 5811
'. C0KE$A
(. P/+E
A
11
$
,hat cancer in wo*en *ost co**only
*etastasi;es to the skin.
1. Breast cancer
$. Medullary thyroid carcino*a
%. 5lio#lasto*a *ultifor*e
'. Colon adenocarcino*a
(. Cer3ical cancer
A
11
%
,hich of the followin& is true re&ardin&
poikiloder*atous *ycosis fun&oides.
1. Ma4ority of cases are predo*inantly C0C=P>
$. Patients typically ha3e a later a&e of onset co*pared
to classic *ycosis fun&iodes
%. Can #e associated with 8yP
'. More wo*en than *en aMected
(. Patients typically do not respond well to phototherapy
C
11
'
All of the followin& state*ents re&ardin& Basal Cell
Ee3us Syndro*e are true +OC+P/:
1. Associated tu*ors include *edullo#lasto*a
$. 1t is inherited in an autoso*al recessi3e *anner
%. Fyperteloris* is a feature
'. /he aMected &ene is *utated in %!"'!N of sporadic
#asal cell carcino*as
(. All of these answers are correct
B
11
(
,hat is the *ost co**on location for this rapidly
&rowin& tu*or.
1. Fead and neck
$. Chest
%. Back
'. Ar*s
(. 8e&s
).
A
11
)
A patient with a innu*era#le disse*inated
keratoacantho*as: includin& lesions on the laryn<
and oral *ucosa:
1. 1s unlikely to ha3e pal*oplantar in3ol3e*ent
$. 8ikely has an underlyin& i**une de6ciency
%. 1s at hi&h risk for *yelodysplasia
'. 8ikely inherited their condition in an autoso*al
do*inant *anner
(. 8ikely de3eloped the* durin& adulthood
).
+
11
A
/he *ost co**on location of Merkel cell carcino*a
is:
1. 0i&its
$. /runk
%. 5enitalia
'. +<tre*ities
(. Fead and neck
+
11
C
/his lesion is associated with which of the followin&: 1. FP? (
$. FP? 11
%. FP? '
'. FP? A
(. FP? 1
B
11
D
Characteristics indicati3e of a hi&h risk of *etastasis
with SCC include:
1. Mitotic rate
$. +<tre*ity location
%. ,ell diMerentiated
'. 0eep in3asion
(. Papillo*a3irus infection
0
1$
!
,hich of the followin& would you not e<pect to see
under der*oscopy.
1. Maple leaf pattern
$. Ar#ori;in& #lood 3essels
%. Blue"&rey o3oid nests
'. 9ran&e crust
(. Milky red &lo#ules
+
1$
1
,hich of the followin& ethnic &roups are co**only
dia&nosed with der*atosis papulosa ni&ra:
1. Asians
$. Fispanics
%. African"A*ericans @ Fispanic patients
'. Caucasians
(. Eo diMerence #etween ethnic &roups
C
1$
$
A child presents with a &iant con&enital ne3us
o3erlyin& the #ack of the skull: e<tendin& onto the
shoulders. 1t is _1(N #ody surface area: sparin& the
face and anterior neck. ,hich test should #e
ordered.
1. A head C/
$. A head MH1
%. A skull plain 6l* O"ray
'. A skin #iopsy
(. A P+/ scan
B
1$
%
,hich area of the face recei3es the *ost cu*ulati3e
e<posure to B? radiation.
1. 0orsu* of nose
$. 9r#ital re&ion
%. Base of the nose
'. Chin
C
1!A
(. Central cheek
1$
'
0es*oplastic trichoepithelio*as are co**only
located on:
1. 8e&s
$. Chest
%. Back
'. 2ace
(. Scalp
0
1$
(
Pseudorosettes in Merkel cell carcino*a: 1. Are seen in the tra#ecular 3ariant
$. Are seen in the inter*ediate"cell type
%. Are seen in the s*all"cell type
'. All of these answers are correct
(. Eone of these answers are correct
A
1$
)
Se;ary syndro*e: 1. Fas characteristic Se;ary cells in peripheral #lood
$. 1s the leuke*ic 3ariant of Mycosis fun&oides
%. 1s characteri;ed #y the triad of pruritic erythroder*a:
&enerali;ed ly*phadenopathy: and presence of Se;ary cells in
peripheral #lood
'. 1s associated with a poor pro&nosis
(. All of these answers are correct
+
1$
A
A patient has a '.( ** ulcerated *elano*a without
re&ional or distant *etastases. Accordin& to the new
A7CC criteria: what *elano*a sta&e does this
correspond to.
1. 1n situ
$. Sta&e 1
%. Sta&e 11
'. Sta&e 111
(. Sta&e 1?
C
1$
C
,hich of the followin& 3ariants of *ycosis fun&oides
is #est dia&nosed usin& a punch #iopsy instead of a
#road super6cial sha3e #iopsy.
1. ,orin&er"Kolopp pa&etoid reticulosis
$. Syrin&otropic *ycosis fun&oides
%. Ketron"5ood*an pa&etoid reticulosis
'. Poikiloder*atous *ycosis fun&oides
(. Se;ary syndro*e
B
1$
D
,hich of the followin& #est descri#es the incidence
of skin cancer in transplant recipients fro* &reatest
to least.
1. BCC`*elano*a`SCC`Merkel cell
$. SCC`BCC`*elano*a`Merkel cell
%. BCC`SCC`*elano*a`Merkel cell
'. SCC`BCC`Merkel cell`*elano*a
(. Merkel cell`SCC`*elano*a`BCC
B
1%
!
,hich of the followin& lesions are J#etter felt than
seenJ:
1. Se#orrheic keratosis
$. SCC in situ
%. Actinic keratosis
'. Se#aceous hyperplasia
(. All of these answers are correct
C
1%
1
0er*ato6#rosarco*a protu#erans is: 1. Cyto&enetically characteri;ed #y reciprocal
translocation t=1Ac$$>=L$$cL1%>
$. 2actor O111a positi3e
%. C+A positi3e
'. C0 %' positi3e
(. Cyto&enetically characteri;ed #y reciprocal
translocation t=1Ac$$>=L$$cL1%> and C0 %' positi3e
+
1%
$
A )! year"old fe*ale presents with a well"
de*arcated: scaly: erythe*atous plaLue on her
ri&ht shin. /he #iopsy shows full thickness epider*al
atypia with scattered *itotic 6&ures and o3erlyin&
parakeratosis. Fower3er: the #ase*ent *e*#rane
re*ains intact. Accordin& to the afore*entioned
infor*ation: the dia&nosis is:
1. BCC
$. SCC
%. BowenGs disease
'. An&iosarco*a
(. C/C8
C
1%
%
A %"year"old &irl presents with *ultiple s*all:
an&ulated: 6r* nodules. /here is a positi3e Itent
si&nI and #iopsy re3eals &host cells and &er*inati3e
cells. 9f the followin& conditions associated with
*ultiple pilo*atrico*as: which is thou&ht to #e
*ost closely linked.
1. /urnerGs
$. Myotonic dystrophy
%. Hu#enstein"/ay#i
'. Sarcoidosis
(. 5ardnerGs syndro*e
B
1%
'
All of the followin& are risk factors for *etastasis
fro* a pri*ary sLua*ous cell carcino*a +OC+P/:
1. 1ncreasin& tu*or si;e
$. 8ocation on the ear
%. Hecurrent tu*or
'. /u*or within ulcer
(. All of these answers are correct
+
1%
(
Si<ty"year old: *ale patient that presents with a
Jstuck onJ: wa<y: hyperkeratotic and
hyperpi&*ented plaLue on his #ack. /he *ost likely
dia&nosis is:
1. Actinic keratosis
$. SCC in situ
%. An&iosarco*a
'. Se#orrheic keratosis
(. Eone of these answers are correct
0
1%
)
Merkel cell carcino*a has #een found to #e
associated with which of the followin& 3iruses.
1. Ferpes 3irus
$. Polyo*a3irus
%. Para*y<o3irus
'. 2la3i3irus
(. +ntero3irus
B
1%
A
A patient presents with tender papules with a
pseudo"0arierGs si&n. She has other fa*ily *e*#ers
with the sa*e condition. Screenin& should #e
perfor*ed to rule out which *ali&nancy.
1. 5astric carcino*a
$. 93arian carcino*a
%. Henal cancer
'. /esticular cancer
(. 8un& cancer
C
1%
C
,hat is the *ost likely dia&nosis. 1. AcLuired di&ital 6#rokerato*a
$. Supernu*ery di&it
%. ?erruca
'. 1nfantile di&ital 6#ro*a
(. Acrochordon
A
1%
D
,hich of the followin& i**unohistoche*ical
*arkers *ay #e indicati3e of *etastatic potential
for *erkel cell carcino*a.
1. Chro*o&ranin
$. Synaptophysin
%. C0''
C
1!C
'. CK$!
(. //2"1
1'
!
All of the followin& are true re&ardin& curetta&e of
&iant con&enital *elanocytic ne3i e<cept:
1. /reat*ent re*ains a contro3ersial topic
$. Best perfor*ed durin& the 6rst $ weeks of life
%. 0ecreases the risk of *elano*a
'. 9Mers an adeLuate alternati3e to sur&ical e<cision
(. Mandates careful lon&"ter* follow"up
C
1'
1
A patient ha3in& Mohs sur&ery for a sLua*ous cell
carcino*a on the ear has tu*or in3adin& the
cartila&e. ,hat sta&e disease does the patient
ha3e.
1. /!
$. /1
%. /$
'. /%
(. /'
+
1'
$
All of the followin& cytokines ha3e de*onstrated
therapeutic #ene6t in the treat*ent of *elano*a
+OC+P/:
1. 12E"alpha
$. 18"$
%. /E2"alpha
'. 18"1!
(. 5M"CS2
+
1'
%
All of the followin& are true of thick *elano*as =`%
**> e<cept:
1. Predo*inantly nodular type
$. ,o*en aMected *ore than *en
%. Predilection for the head and neck
'. Mainly in older patients =`(! years>
(. Associated with fewer ne3i
B
1'
'
All of the followin& are true of *elano*a"associated
leukoder*a e<cept:
1. 8esions rese*#le 3itili&o
$. Portends a worse pro&nosis
%. Seen in patients with *etastatic disease #ut no
pri*ary lesion
'. Fistolo&y rese*#les that of a halo ne3us
(. 8esions de3elop distant to *elano*a
B
1'
(
,hich of the followin& *arkers do not stain
*elanocytic lesions:
1. Eeuron speci6c enolase
$. ?i*entin
%. S"1!!
'. FMB"'(
(. All of these answers are correct
A
1'
)
Merkel cell carcino*a should #e treated with what
si;e sur&ical *ar&ins.
1. $**
$. (**
%. 1c*
'. %c*
(. (c*
0
1'
A
1*iLui*od is an i**une response *odi6er that
sti*ulates innate and cell *ediated i**une
pathways. 1t induces all of the followin& cytokines
+OC+P/:
1. 18"1
$. 18"'
%. 18"(
'. 18")
(. 18"C
B
1'
C
,hich neoplas* is associated with the Stewart"
/re3es syndro*e.
1. Henal leio*yo*as
$. Basal cell carcino*a
%. An&iosarco*a
'. Keratoacantho*a
(. / cell ly*pho*a
C
1!D
A. Medical Mycolo&y
# Question Answers An
s
1 /he *a4or ende*ic area for
Fistoplas*osis
1. Africa
$. Central A*erica
%. Southwest Bnited States
'. South A*erica
(. +astern Bnited States
).
+
$ Eonder*atophytes &rowin& on
0er*atophyte /est Media cause the *edia
to turn what color.
1. A*#er
$. Hed
%. Sellow
'. Black
(. 5reen
).
C
% All of the followin& para*eters are used to
distin&uish der*atophytes e<cept:
1. Eutritional reLuire*ents
$. Colony *orpholo&y
%. Sucrose hydrolysis
'. Fair -uorescence
(. 5rowth te*perature
).
C
' /his or&anis* is often considered a
conta*inant #ut has #een reported to
cause onycho*ycosis:
1. Sepedoniu*
$. Cur3ularia
%. Scopulariopsis
'. Penicilliu*
(. Phialophora
).
C
( /richophyton tonsurans sporulates 3ia
thick"walled round cells resistant to the
en3iron*ent known as:
1. Arthroconidia
$. Blastoconidia
%. Chla*ydoconidia
'. Sporan&ia
(. Mycelia
).
C
) /richosporon o3oides is a cause of: 1. Black piedra
$. ,hite piedra
%. /inea ni&ra pal*aris
'. +ctothri< tinea capitis
(. +ndothri< tinea capitis
).
B
A A patient with white nodules on the hair
shaft has a K9F which shows hyphae and
arthroconidia. /he etiolo&y is:
1. Coryne#acteriu*
*inutissi*u*
$. +<ophiala wernickii
%. Piedraia hortae
'. /richosporon #ei&elii
(. Coryne#acteriu* tenuis
).
0
C A fun&al culture de*onstrates a suedelike
crea*"colored colony of teardrop and
#alloon"shaped *icroconidia which
produce a red"#rown pi&*ent. ,hich of
the followin& is true of this or&anis*.
1. Causes ectothri< infection
$. HeLuires partial thia*ine
for &rowth
%. 0oes not ha3e
arthroconidia
B
11!
'. Causes -uorescent hair
infection
(. 1s not a cause of tinea
un&ui*
).
D Mycelia can for* structures with a co*#"
lke appearance called:
1. Hacket for*s
$. 2a3ic chandeliers
%. Pectinate #odies
'. Spiral hyphae
(. Eodular #odies
).
C
1! 5rowth of which of the followin& is not
inhi#ited on Mycosel *edia.
1. Cryptococcus neofor*ans
$. Seast for*s of Fistoplas*a
%. Seast for*s of Blasto*yces
'. Microsporu* &ypseu*
(. Scytalidiu* species
).
0
11 ,hich of the followin& or&anis*s would
you e<pect to reco3er fro* a -uorescent
tinea capitis.
1. /. tonsurans
$. M. &ypseu*
%. M. canis and M. &ypseu*
'. /. 3iolaceu*
(. /. ru#ru*
).
C
1$ ,hich of the followin& fun&i can cause an
endothri< tinea capitis and fa3us.
1. /. tonsurans
$. M. canis
%. /. schoenleinii
'. M. audouinii
(. /. ru#ru*
).
C
1% All of the followin& state*ents a#out
paracoccidioido*ycosis are true +OC+P/.
1. 1t is *ost co**on in *ale
a&ricultural workers
$. 1t has a characteristic
J*arinerJs wheelJ
appearance on
histopatholo&y
%. 0isease is al*ost always
con6ned to the skin
'. 1t is ende*ic to Bra;il
(. 1t *ay cause
*ucocutaneous lesions
).
C
1' ,hich of the followin& state*ents
re&ardin& super6cial *ycotic infections is
/HB+.
1. Malasse;ia species do not
-uoresce under a ,oodJs
la*p
$. Phaeoannello*yces
wernecki causes tinea
ni&ra
%. /richophyton #ei&elii
causes white piedra
'. /richosporon hortae causes
#lack piedra
(. Micrococcus sedentarius
causes tinea ni&ra
).
B
1( ,hich of the followin& usually does not 1. M. audouinii C
111
-uoresce #ri&ht &reen upon ,oods la*p
e<a*ination.
$. M. canis
%. /. 3iolaceu*
'. /. schoenleinii
(. M. distortu*
).
1) ,hich of the followin& 09+S E9/ typically
cause white super6cial onycho*ycosis.
1. Asper&illus species
$. 2usariu* species
%. /richophyton
*enta&rophytes
'. Scopulariopsis species
(. /richophyton ru#ru*
).
+
1A Sa#ouraud 0e<trose A&ar =S0A> +**ons
Modi6cation contains which of the
followin&.
1. Peptones
$. Phenol red
%. Chlora*phenicol
'. 5enta*icin
(. Cyclohe<i*ide
).
A
1C /his 1) year"old patient was recently
dia&nosed with F1?: the dia&nosis is:
1. 0istal 9nycho*ycosis
$. Pro<i*al Su#un&ual
9nycho*ycosis
%. Pro<i*al ,hite Su#un&ual
9nycho*ycosis
'. ,hite Super6cial
9nycho*ycosis
(. Paronychia with Candida
9nycho*ycosis
).
C
1D ,hich two characteristics co*#ined for*
a si&ni6cant risk for acLuirin&
sporotrichosis. 1. Ani*al handler $. Male
&ender %. Alcoholis* '. 2ilipino or African
decent (. 5enetic predisposition
1. 1: $
$. 1: %
%. %: '
'. ': (
(. %: '
).
B
$! Septate true hyphae are characteri;ed #y: 1. /rans3erse cross walls
for*in& within the hyphae
$. 0iscrete unicellular #odies
%. Constrictions at septations
'. Branchin& occurin& at
septations
(. A ter*inal cell that is
s*aller than the others
).
A
$1 A 1$ year old #oy has a pruritic #ullous
eruption on his feet. A K9F is positi3e and
a fun&al culture shows *icroconidia in
&rape"like clusters. /he etiolo&y is:
1. /richophyton 3errucosu*
$. Microsporu* canus
%. /richophyton
*enta&rophytes
'. Microsporu* &ypseu*
(. /richophyton tonsurans
).
C
$$ /he *ost relia#le *ethod for
distin&uishin& #etween /richophyton
ru#ru* and /. *enta&rophytes is:
1. Morpholo&y of
*icroconidia
$. Morpholo&y of
*acroconidia
%. Pi&*entation studies
0
11$
'. Fair perforation test
(. Colony *orpholo&y
).
$% Culturin& /. ru#ru* fro* a white opacity
on the 6n&ernail plate should pro*pt
testin& for what.
1. 0ia#etes *ellitus
$. Fypothyroidis*
%. Fyperthyroidis*
'. F1?
(. Cirrhosis
).
0
$' ,hich actino*ycotic or&anis* has red
&rains.
1. Strepto*yces so*aliensis
$. Eocardia asteroides
%. Actino*adura *adurae
'. Actino*adura pelletieri
(. Eocardia #rasiliensis
).
0
$( /his der*atophyte has a &rowth
reLuire*ent for inositol and thia*ine
1. /richophyton eLuinu*
$. /richophyton 3iolaceu*
%. /richophyton concentricu*
'. /richophyton tonsurans
(. /richophyton 3errucosu*
).
+
$) ,hich der*atophyte is *ost co**only
responsi#le for tinea corporis &ladiotoru*.
1. /. *enta&
$. /. tonsurans
%. /. schonlenleinii
'. /. ru#ru*
(. +. -occosu*
).
B
$A ,hich of the followin& state*ents
re&ardin& *yceliu* is E9/ true.
1. A *ass of hyphae is
*yceliu*
$. Myceliu* has reproducti3e
capa#ility
%. Fyphae for*in&
corkscrew"like turns are
spiral hyphae
'. Pectinate #odies are
hyphae rese*#lin& a co*#
(. Hacket for*s are clu#"
shaped cells
).
B
$C ,hich of the followin& is a -uorescent
ectothri< der*atophyte.
1. /richophyton ru#ru*
$. /richophyton
*enta&rophytes
%. Microsporu* ferru&ineu*
'. /richophyton 3iolaceu*
(. Microsporu* nanu*
).
C
$D ,hich of the followin& is E9/ used for
histolo&ic e<a*ination for fun&al
infection.
1. Chlora;ol Black"+
$. 5or*ori Methana*ine
Sil3er
%. Periodic Acid SchiM
'. 2ontana"Masson
(. MayerGs *ucicar*ine
).
A
%! ,hich of the followin& state*ents
re&ardin& histoplas*osis is /HB+.
1. /er#ina6ne is the
treat*ent of choice
C
11%
$. Fistoplas*a capsulatu* is
a yeast at $(JC
%. /he or&anis*s are
intracellular on histolo&ical
e<a*ination
'. /he disease is *ost
co**on in the San
7oaLuin ?alley
(. /he disease is pri*arily a
*ucocutaneous infection
).
%1 ,hich patho&en is not inhi#ited #y
cyclohe<i*ide.
1. Cryptococcus
$. Candida al#icans
%. Prototheca
'. Scopuloniopsos #re3icaulis
(. Scytalidiu* species
).
B
%$ A landscape worker co*plained of se3eral
tender nodules on the ri&ht dorsal hand
and forear*. /he #iopsy of the lesion
showed asteroid #odies #ut no or&anis*s.
/he likely dia&nosis is:
1. Eocardiosis
$. Blasto*ycosis
%. Sporotrichosis
'. Candidiasis
(. Coccidioido*ycosis
).
C
%% All of the followin& state*ents re&ardin&
super6cial *ycotic infections are true
+OC+P/:
1. /richosporon species can
cause syste*ic disease in
i**unoco*pro*ised
patients
$. Malasse;ia furfur is the
*ost co**on cause of
tinea 3ersicolor
%. /richosporon #ei&elii
causes white piedra
'. Malasse;ia species *ay #e
associated with neonatal
cephalic pustulosis
(. Piedraia hortae causes
#lack piedra
).
B
%' ,hich of the followin& state*ents a#out
arthroconidia is correct.
1. Arthroconidia are for*ed
#y #uddin&
$. Arthroconidia are for*ed
#y fra&*entation of
hyphae
%. Arthroconidia are thick"
walled round cells
'. Arthroconidia are spores
that are produced in a sac
(. Arthroconidia are yeast
for*s of di*orphic fun&i
).
B
%( All of the followin& are features of
*yceto*a e<cept:
1. Swellin&
$. Self"li*ited
%. 5ranules
'. 2ascia and #one
in3ol3e*ent
B
11'
(. 0rainin& sinuses
).
%) ,hich of the followin& state*ents
re&ardin& der*atophyte infection 2A8S+.
1. /richophyton schoenleinii
is a co**on cause of
fa3us
$. Microsporu* canis is
associated with ectothri<
tinea capitis
%. /richophyton 3iolaceu* is
nor*ally associated with
endothri< tinea capitis
'. Microsporu* audouinii
displays yellow
-uorescence with ,oodJs
la*p e<a*ination
(. /richophyton ru#ru* is
always an ectothri<
infection
).
+
%A /he outstandin& characteristics of
Asper&illus species on #iopsy include:
1. Blastoconidia
$. Fyaline: septate
dichoto*ously #ranchin&
hyphae
%. Copper pennies
'. Hi##on"like 6la*ents that
*ay #e twisted and
distorted #ranchin& at
ri&ht an&les
(. Stain with 2ontana"Mason
stain
).
B
%C ,hich one of the followin& is not caused
#y a Candida infection.
1. An&ular cheilitis
$. Balanitis
%. Median rho*#oid &lossitis
'. 8eukoplakia
(. Myceto*a
).
+
%D Althou&h this or&anis* is not a fun&us: it
stains with PAS and 5MS and produces
spherules in tissue. /his or&anis* can #e
identi6ed as:
1. Hhinosporidiu* see#eri
$. Coccidioides i**itis
%. Penicilliu* *arneMei
'. Prototheca wickerha*i
(. 8eish*ania *e<icana
).
0
'! A #iopsy shows #road"#ased #uddin& thick
walled yeast cells: 1!"1( u* with a dou#le
contoured appearance.
1. /his yeast has a yeast
phase at roo*
te*perature
$. 0oes not &row at %AJ C
%. Bsually produces a se3ere
characteristic pul*onary
disease
'. May #e found in do&s
(. 1s trans*itted #y
*osLuitoes
).
0
'1 A ()"year"old *ale with F1? presents with 1. Cryptococcus +
11(
*ultiple u*#ilicated #rown papules on the
face. ,hich of the followin& is the least
likely cause of his lesions.
$. Fistoplas*osis
%. Coccidio*ycosis
'. Penicilliosis
(. Blasto*ycosis
).
'$ ,hich of the followin& causes tinea
i*#ricata.
1. +pider*ophyton -occosu*
$. /richophyton concentricu*
%. /richophyton ru#ru*
'. /richophyton
*enta&rophytes
(. /richophyton tonsurans
).
B
'% ,hich of the followin& stains is speci6c for
chitin.
1. K9F
$. K9F with 0MS9
%. Swart; 8a*kins
'. Chlora;ol Black +
(. Calco-uor ,hite
).
0
'' ,hich of the followin& *ethods of direct
*icroscopic e<a*ination for fun&i is
&lucan speci6c.
1. K9F
$. Swart; 8a*kins
%. Chlora;ol #lack +
'. Calco-uor white
(. MayerGs *ucicar*ine
).
0
'( /he or&anis* that causes white piedra: 1. 0oes not cause
onycho*ycosis
$. 1s known as Piedraia
hortae
%. May also cause post"
operati3e wound infections
'. 5rows as s*all: co*pact:
#lack"&reenish 3el3ety
colonies
(. Can only #e treated #y
cuttin& oM aMected hairs
).
C
') Penicilliu* *arneMei is an infection
ende*ic to which part of the world.
1. Me<ico
$. South A*erica
%. Africa
'. Southeast Asia
(. /he Cari##ean
).
0
'A Black &ranules are found in *yceto*a
caused all the followin& or&anis*s e<cept:
1. Madurella &risea
$. M. *yceto*atis
%. +<ophiala 4eansel*ei
'. Cur3ularia
(. Scedosporiu*
apiosper*u*
).
+
'C A neutropenic patient has erythe*atous
nodules for se3eral days. A #iopsy shows
#ranchin& septate hyaline hyphae. ,hich
of the followin& conditions should #e
included in the diMerential. 1.
Coccidioido*ycosis $. 2usariosis %.
1. 1
$. 1: $
%. $: %
'. %: '
(. $: %: (
).
C
11)
Asper&illosis '. Ky&o*ycosis (.
Phaeohypho*ycosis
'D A patient returns fro* a 3acation in Bra;il
with keloidal"like nodules on the face and
ar*s. /he patient denies any sick contacts
or e<posures and reports only lyin& on the
#each and swi**in& with dolphins. She
likely has:
1. Actino*ycosis
$. 8o#o*ycosis
%. Chro*o#lasto*ycosis
'. Mucor*ycosis
(. Sporotrichosis
).
B
(! /his or&anis* is the *ost co**on cause
of eu*ycotic *yceto*a in the BS:
1. Madurella *yceto*atis
$. Eocardia asteriodes
%. Scedosporiu*
apiosper*u*
'. Phialophora 3errucosa
(. ,an&iella der*atitis
).
C
(1 ,hich of the followin& or&anis*s will
cause infections of skin: nails and
endothri< hair.
1. +pider*ophyton -occosu*
$. Microsporu* audouinii
%. /richophyton schoenlinii
'. Microsporu* canis
(. /richophyton
*enta&rophytes
).
C
($ An or&anis* producin& an apricot colored
colony and re-e<i3e #ranchin& with few
conidia was cultured fro* a patient fro*
Africa. ,hich of the followin& isare true.
1. /his *ostly likely is /. 3errucosu* $.
/his *ost likely is /. soudanense %. /his
*ost likely is /. 3iolaceu* '. /his
or&anis* causes endothri< tinea capitis (.
/his or&anis* is ;oophilic
1. 1:(
$. $:'
%. $:':(
'. %: '
(. %: ': (
).
B
(% Clinically: actino*ycotic *yceto*a and
eu*ycotic *yceto*a appear identical.
/he i*portance of identifyin& the etiolo&ic
a&ent is
1. Acade*ic
$. Selectin& the appropriate
therapy
%. 9rderin& appropriate
stains
'. 0eter*ine if the infection
is conta&ious
(. 0eter*ine if a*putation is
necessary
).
B
(' ,hich of the followin& stat*ents
re&ardin& pseudohyphae is incorrect.
1. Pseudohyphae are seen in
yeasts
$. Are constricted at
septations
%. Branchin& occurs at
septations
'. /he ter*inal cell is s*aller
than the others
(. Are not septated
).
+
(( ,hich of the followin& or&anis*s is *ost
likely to cause a sporotrichoid nodule on
the ar*:
1. Eocardia #rasiliensis
$. Phialophora 3errucosa
%. Hhinospiridiu* see#erii
'. 2usariu*
A
11A
(. 2onsecaea pedrosoi
).
() ,hich of the followin& der*atophytes
causes endothri< tinea capitis.
1. Microsporu* &ypseu*
$. Microsporu* audouinii
%. /richophyton tonsurans
'. Microsporu* canis
(. Microsporu* ferru&ineu*
).
C
(A A crea*y white colony *i&ht #e any of
these or&anis*s e<cept:
1. Candida al#icans
$. Prototheca wickerha*ii
%. Cur3ularia
'. Sporothri< schenckii at
%AJ C
(. Cryptococcus neofor*ans
).
C
(C /his or&anis* &rew on Sa#ouraud
0e<trose a&ar without any anti*icro#ials.
/he patient presented with onycho*ycosis
of #oth &reat toenails. /he nails were dark
and dystrophic: and thick scale was
apparent on #oth feet. 1dentify the fun&us.
1. /richophyton ru#ru*
$. Microsporu* distortu*
%. Scytalidiu* di*idiatu*
'. Coccidioides i**itis
(. /richophyton 3iolaceu*
).
C
(D ,hat or&anis* produces round thick
walled spiny *acroconidia and pear
shaped *icroconidia.
1. Sporothri< schenckii
$. Blasto*yces der*atitidis
%. Paracoccidioides
#rasiliensis
'. Cryptococcus neofor*ans
(. Fistoplas*a capsulatu*
).
+
)! Cutaneous lesions of Cryptococcosis *ay
#e 1. Eodular $. Papular %.
5ranulo*atous"ulcerati3e '. Ferpetifor*
(. Cellulitis"like:
1. $: %: '
$. %: ': (
%. $: %: '
'. 1: %: ': (
(. All of these answers are
correct
).
+
)1 ,hat is the *ost freLuently reported
cause of pri*ary cutaneous asper&illosis.
1. Asper&illus -a3us
$. Asper&illus fu*i&atus
%. Asper&illus ni&er
'. Asper&illus solani
(. Asper&illus *arneMei
).
A
)$ ,hich of the followin& state*ents
re&ardin& candidal infection is 2A8S+.
1. Candida species displays
true hyphae on potassiu*
hydro<ide e<a*ination
$. Predisposin& factors for
candidal infection include
dia#etes *ellitus:
hyperhidrosis and #road
spectru* anti#iotics
%. Candida al#icans is the
nu*#er one cause of
*ucocutaneous infections
'. Candidal infections
typically do not spare the
scrotu*
A
11C
(. Candida species *ay #e
associated with &ranulo*a
&luteale infantu*
).
)% ,hich of the followin& is the *ost useful
*orpholo&ic feature in identifyin& the
*ycelial phase of Fistoplas*a
capsulatu*.
1. Arthroconidia in e3ery
other cell
$. +ncapsulated spores $"(
u*
%. /u#erculate *acroconidia
C"1' u*
'. S*all o3al conidia on lon&
thin conidiophores
(. Microconidia laterally
alon& the hyphae strand
).
C
)' A 'D"year"old *an has painless
su#cutaneous nodules on his feet with
sinus tracts and a#scesses. Patholo&y
shows I&rainI in sinus tract draina&e. A
dia&nosis of eu*ycotic *yceto*a is
*ade. ,hat is the *ost co**on cause in
the Bnited States.
1. Acre*oniu*
$. Cur3alaria
%. +<ophilia 4eansel*ei
'. Pseudallescheria #oydii
(. Eocardia
).
0
)( 9f the followin& Candida species: which is
likely to cause disse*inated Candidiasis
with cutaneous lesions.
1. Candida al#icans
$. C. parapsilosis
%. C. tropicalis
'. C. krusei
(. C. neofor*ans
).
C
)) A %A year old wo*an fro* Eew Me<ico:
now %! weeks pre&nant: presents with -u"
like sy*pto*s. Chest <"ray re3ealed
diMuse *iliary in6ltrates: with #lood
cultures &rowin& Coccidioidis i**itis.
,hat is the treat*ent of choice.
1. A*photericin B
$. /er#ina6ne
%. 1tracona;ole
'. 5riseoful3in
(. Eo therapy
).
A
)A A pet store owner co*es into your oTce
with pruritic scaly plaLues on his ar*s. A
fun&al culture de*onstrates a yellow
colony with spindle"shaped *acroconidia
which &rows on polished rice &rains. /he
or&anis* is:
1. Microsporu* canis
$. +pider*ophyton -occosu*
%. /richophyton ru#ru*
'. Microsporu* &ypseu*
(. /richophyton tonsurans
).
A
)C ,hich of the followin& is true re&ardin&
culture of the or&anis*s that cause
Pityriasis 3ersicolor.
1. 0iTcult to &row: reLuires
oli3e oil o3erlay
$. 5row easily on Mycosel
*edia
%. Cannot #e cultured
'. 5row easily on
0er*atophyte /est Media
(. 5row easily on Sa#ouraud
0e<trose A&ar
).
A
)D ,hich of the followin& is *ost likely to #e
a pri*ary cutaneous infection.
1. Eorth A*erican
Blasto*ycosis
$. Fistoplas*osis
%. Paracoccidioido*ycosis
'. Cryptococcosis
A
11D
(. Penilliosis
).
A! A %'"year"old *ale patient presents with a
3errucous lesion of the nasal *ucosac the
#iopsy showed spherules ran&in& in si;e
fro* $!! to %$( u*. /he *ature
endospores ha3e a rou&h appearance. /he
dia&nosis is:
1. Coccidioido*ycosis
$. Protothecosis
%. Hhinosporidiosis
'. Pseudallescheriosis
(. Cryptococcosis
).
C
A1 ,hich of the followin& is 2A8S+ with
re&ards to ase<ual reproduction of fun&i.
1. Arthroconidia are for*ed
#y the fra&*entation of
hyphae
$. Sporan&ia are spores that
are produced in a sac
%. Chla*ydoconidia are thin"
walled and are suscepti#le
to en3iron*ental in4ury
'. Conidia are cells produced
on the sides or ends of
hyphae
(. 0e*atophytes produce
conidia
).
C
A$ /his a&ent causes a super6cial:
asy*pto*atic infection usually on the
pal*s of the hands. /he lesions are -at:
nonscaly and appear as irre&ularly shaped
#rown *acules:
1. Piedra hortae
$. Cladosporiu* carrionii
%. Aureo#asidiu* pullulans
'. Phaeoannello*yces
werneckii
(. +<ophiala 4eansel*ei
).
0
A% ,hich of the followin& is true re&ardin&
0er*atophyte /est Media =0/M>.
1. 0/M contains
chlortetracycline and
*inocycline
$. Ali;arin red is the indicator
present in 0/M
%. Eon"der*atophytes cause
the *edia to turn yellow
due to acid #yproducts
'. 0/M is useful for culturin&
der*atophytes fro* skin
and nails: #ut not hair.
(. 0er*atophytes utili;e
&lucose as a car#on
source: producin& alkaline
#y"products.
).
C
A' Choose the correct state*ent re&ardin&
Coccidioido*ycosis:
1. /he *ost co**on for* of
pri*ary inoculation is
cutaneous
$. 0isse*ination *ay in3ol3e
the #ones: 4oints: 3iscera:
#rain and skin
%. Causati3e or&anis*: C.
i**itits: is a thick"walled
spherule with a
polysaccharide capsule
B
1$!
de*onstrated with Alcain
#lue
'. +rythe*a nodosu* is a
poor pro&notic si&n
(. 9ut#reaks occur in the
Mississippi and 9hio Hi3er
?alley
).
A( ,hich one of the followin& a&ents
accounts for the depi&*entation seen in
pityriasis 3ersicolor.
1. /hy*idine kinase
$. Ketocona;ole
%. Acetone
'. 0icar#ocyclic acid
(. Postin-a**atory eMect
).
0
A) ,hich of the followin& is not true
re&ardin& fun&al culture *edia containin&
cyclohe<i*ide.
1. Cyclohe<i*ide is not found
in Sa#ouraud 0e<trose
A&ar =S0A> +**ons
Modi6cation
$. Cyclohe<i*ide is found in
Mycosel
%. Cyclohe<i*ide is found in
0er*atophyte /est Media
'. Cyclohe<i*ide is found in
Myco#iotic
(. Cyclohe<i*ide inhi#its
#acterial -ora
).
+
AA Septate hyphae with D!J #ranchin& and
thick walled #arrel shaped arthroconidia
alternatin& with e*pty cells #est descri#es
the *icroscopic *orpholo&y of:
1. Fistoplas*a capsulatu*
$. Sporothri< schenckii
%. Microsporu* &ypseu*
'. /richophyton tonsurans
(. Coccidioides i**itis
).
+
AC /inea i*#ricata is *ost freLuently caused
#y:
1. /. *enta&rophytes
$. M. Audouinii
%. /. concentricu*
'. +. -occosu*
(. M. furfur
).
C
AD ,hat is the *ost likely cause of this
infection.
1. /. tonsurans
$. /. schoenleinii
%. M. canis
'. /. *enta&
(. /. ru#ru*
).
C
C! A patient has a positi3e ,oodGs li&ht e<a*
that is caused #y pteridine. ,hat is the
causati3e condition.
1. Microsporu* ferru&ineu*
$. Coryne#acteriu*
%. /richophyton 3iolaceu*
'. Pseudo*onas
(. /richophyton tonsurans
).
A
C1 ,hich of the followin& stains is E9/ used
to stain fun&al ele*ents.
1. Mucicar*ine
$. Periodic Acid SchiM
%. 2ontana"Masson
'. ?on Kossa
0
1$1
(. 5or*ori *ethena*ine
sil3er
).
C$ A *ass of hyphae is known as a: 1. Sporan&ia
$. Conidia
%. Myceliu*
'. Chla*ydoconidia
(. Pseudohyphae
).
C
C% /he *ost sensiti3e *icroscopic test for
fun&al infection is:
1. Potassiu* Fydro<ide
$. Potassiu* Fydro<ide with
0MS9
%. Chlora;ol Black +
'. Calco-uor white
(. Swart; 8a*kins stain
).
0
C' ,hich of the followin& state*ents
re&ardin& lo#o*ycosis is 2A8S+.
1. 1tracona;ole is the
treat*ent of choice
$. 1t rese*#les a Jchain of
coinsJ on histopatholo&y
%. 1t is also known as
Jkeloidal #lasto*ycosisJ
'. 8aca;ia =for*erly 8o#oa>
lo#oi is the nu*#er one
cause
(. /he infection also occurs in
dolphins
).
A
C( +rythe*atous to 3iolaceous papules that
*ay pro&ress to nodular and necroti;in&
skin lesions in neutropenic patients *ay
#e caused #y which of the followin&
or&anis*s.
1. /richosporon asahii
$. /richosporon #ei&elii
%. /richosporon o3oides
'. /richosporon inkin
(. /richophyton ru#ru*
).
A
C) A child presents with se3eral yellowish:
cup"shaped crusts on the scalp: so*e with
sin&le hairs piercin& throu&h the center.
K9F prep re3eals arthroconidia and
airspaces within the hair shaft. A likely
cause is:
1. M. &ypseu*
$. M. canis
%. /. tonsurans
'. /. 3errucosu*
(. /. *enta&rophytes
).
A
CA /his or&anis* produces an endothri< tinea
capitis:
1. /richophyton
*enta&rophytes
$. Microsporu* &ypseu*
%. Microsporu* nanu*
'. /richophyton 3errucosu*
(. /richophyton soudanense
).
+
CC ,hich structure is found in a #iopsy of
Candida tropicalis: it is #ranchin& and
pinchin& in at the points of septations:
1. Septate hyphae
$. Arthroconidia
%. Mosaic fun&us
'. Pseudohyphae
(. Pectinate #odies
).
0
CD Cryptococcus neofor*ans resides in: 1. /he Mississippi ?alley
re&ion
C
1$$
$. Chicken roosts
%. Pi&eon droppin&s
'. Sandy soil
(. Eone of these answers are
correct
).
D! A #lood culture fro* a neutropenic patient
with onycho*ycosis &rew which of the
followin& or&anis*:
1. Scopulariopsis sp
$. Asper&illus sp
%. 2usariu* sp
'. Acre*oniu* sp
(. /. ru#ru*
).
C
D1 A ) year"old Fispanic &irl ca*e into the
clinic with a history of alopecia and scaly
scalp for % weeks. /he ,oodGs la*p
e<a*ination was ne&ati3e and her cer3ical
ly*ph nodes were not enlar&ed. 1t was
noted that the hairs were #roken oM at the
surface of the scalp. /he *ost likely
or&anis* to #e isolated would #e:
1. M. audouinii
$. M. canis
%. M. &ypseu*
'. /. tonsurans
(. /. ru#ru*
).
0
D$ /his or&anis* does not produce
*icroconidia. /he *acroconidia are clu#
shaped: and s*ooth walled: they &row
sin&ly or in clusters.
1. /richophyton ru#ru*
$. +pider*ophyton -occosu*
%. Microsporu* &ypseu*
'. Microsporu* canis
(. /richophyton
*enta&rophytes
).
B
D% A solitary chancre"like lesion appeared on
the ar* of a -orist who has a pet do&. Eo
or&anis*s were seen on #iopsy: howe3er
Sporothri< schenckii was cultured fro* the
tissue. /his infection is known as J6<ed
cutaneous sporotrichosisJ. 1t re*ains
6<ed #ecause:
1. /here is a resistance due
to a prior e<posure
$. /here is a decreased
resistance due to A10S
%. /he infection was acLuired
fro* the do& rather than
fro* a plant
'. /he infection occurred in
the a#sence of tissue
in4ury
(. /his species of Sporothri<
has li*ited infecti3ity
).
A
D' /he *ost co**on eu*ycotic or&anis* in
the BS produces which color &rains in its
*icrocolony.
1. ,hite
$. Black
%. Hed
'. Sellow
(. 5reen
).
A
D( ,hich of the followin& *ethods of direct
*icroscopic e<a*ination is chitin speci6c.
1. Chlora;ol #lack +
$. Calco-uor white
%. 5o*ori Methena*ine
Sil3er
'. 2ontana"Masson
(. K9F
).
A
D) /he dia&nosis is phaeohypho*ycosis:
what is the or&anis* 1. Alternaria sp. $.
1. 1:$:%
$. $:%:'
C
1$%
Bipolaris sp. %. 2usariu* sp. '. +<ophiala
sp.
%. 1:$:'
'. 1:%:'
(. All of these answers are
correct
).
DA A patient with a pul*onary infection and
cer3ical adenopathy has 3esicles: papules
and ulcerations on the oral and nasal
*ucosa. /issue culture re3eals yeast with
*ultiple #uds &i3in& a J*arinerJs
wheelJ appearance. /he or&anis* is:
1. Penicilliu* *arneMei
$. Coccidioides i**itis
%. Paracoccidioides
#rasiliensis
'. Blasto*yces der*atitidis
(. 8eish*ania *e<icana
).
C
DC ,hich of the followin& *ost accurately
descri#e conidia.
1. Cells produced on the end
or sides of hypha or
conidiophore
$. Spores that are produced
in a sac
%. /hick"walled round cell
'. 2or*ed #y #uddin&
(. 2or*ed #y fra&*entation
of hyphae
).
A
DD ,hich of the followin& state*ents a#out
di*orphic fun&i is 1EC9HH+C/.
1. Are in the *ould for* in
the en3iron*ent
$. Are in yeastspherule for*
in tissue
%. Are in *ould for* at $(
de&rees C
'. Are in yeastspherule for*
at %A de&rees C
(. Are in *ould for* in tissue
).
+
1!
!
A '( year"old a&ricultural worker fro*
Bra;il presented with ulcers of the #uccal
*ucosa and ton&ue. Cer3ical ly*ph nodes
were tender and enlar&ed. /he #iopsy
would *ost likely re3eal:
1. Seast cells in chains and a
lar&e thick walled round
central yeast cell
surrounded #y se3eral
thinly attached #uddin&
s*aller yeast cells
$. Seast cells with lar&e
capsules
%. S*all #uddin& yeast cells
'. Seast cells with
pseudohyphae
(. Copper pennies
).
A
1!
1
/he *ost co**on cause of tinea capitis in
the Bnited States today is:
1. /richophyton schoenleinii
$. /. tonsurans
%. /. *enta&rophytes
'. Microsporu* audouinii
(. M. canis
).
B
1!
$
/he etiolo&ic a&ent responsi#le for ,hite
Piedra is:
1. Candida al#icans
$. Pityrosporu* o#iculare
%. Coryne#acteriu* tenuis
'. Piedra hortai
+
1$'
(. /richosporon o3oides
).
1!
%
An elderly lady with *occasin"type tinea
pedis has a fun&al culture which
de*onstrates s*ooth: teardrop"shaped
*icroconidia which produce a Jport"
wineJ pi&*ent. /he or&anis* is:
1. /richophyton 3errucosu*
$. Microsporu* canus
%. /richophyton ru#ru*
'. Microsporu* &ypseu*
(. /richophyton
*enta&rophytes
).
C
1!
'
A sli*y: *ucoid colony &rowin& on
Sa#ouraudGs a&ar at %A de&rees Celsius is
o#ser3ed to produce urease. /he or&anis*
is:
1. Candida al#icans
$. Cryptococcus neofor*ans
%. Candida &la#rata
'. Candida tropicalis
(. Asper&ilus -a3us
).
B
1!
(
Eu*erous u*#ilicated nodules rese*#lin&
*olluscu* conta&iosu* de3eloped in a
patient with recently dia&nosed F1?
infection. ,hich of the followin& fun&i
*i&ht #e the causati3e a&ent=s>. 1.
Candida tropicalis $. Cryptococcus
neofor*ans %. Asper&illus fu*i&atus '.
Fistoplas*a capsulatu* (. Penicilliu*
*arneMei
1. $
$. %
%. $: '
'. ': (
(. $: ': (
).
+
1!
)
/wo weeks after a #icycle accident a $("
year"old fe*ale dia#etic patient
co*plained of a swollen tender ri&ht
cheek /he PAS #iopsy de*onstrated rin&
for*s and distorted wide hyphae with few
septations and ri&ht an&le #ranchin&. /he
dia&nosis is:
1. Asper&illosis
$. Actino*ycosis
%. Mucor*ycosis
'. 0er*atophytosis
(. 2usariosis
).
C
1!
A
/his or&anis* causes a resistant tinea
pedis indistin&uisha#le fro*
der*atophytosis:
1. Asper&illus -a3us
$. Scytalidiu* di*idiatu*
%. Cur3ularia sp.
'. Scopulariopsis
(. 2onsecaea sp
).
B
1!
C
,hich of the followin& is /HB+ re&ardin&
coccidio*ycosis.
1. 2irst line treat*ent in
pre&nancy is itracona;ole
$. 0roplet trans*ission is the
*ost co**on *ethod of
acLuisition of disease
%. Southeast Asians are at a
hi&her risk of disse*inated
disease
'. +rythe*a nodosu* is
associated with a poor
pro&nosis
(. Appro<i*ately A(N of
those contractin& the
disease will #e
sy*pto*atic
C
1!
D
A horticulturist of spha&nu* *oss
topiaries co*es in with a nodular eruption
with ly*phan&itic spread and treat*ent
1. 5astrointestinal distress
$. Shortness of #reath
%. 2lushin&
A
1$(
with oral potassiu* iodide is initiated.
,hat is the *ost well reco&ni;ed side
eMect of this treat*ent.
'. An&ioede*a
(. Pruritus
11
!
A whitish: heaped and con3oluted colony
with &rowth su#*er&ed into the a&ar and
a colorless re3erse was isolated fro* the
scalp of a %("year"old *ale. /he or&anis*
did not produce any conidia. /he dia&nosis
*ost likely is:
1. Microsporu* canis
$. Microsporu* ferru&ineu*
%. /richophyton ru#ru*
'. /richophyton tonsurans
(. /richophyton schoenleinii
+
11
1
A patient with scaly feet has a positi3e
K9F. 2un&al culture re3eals s*ooth: clu#"
shaped *acroconidia attached to hyphae
in &roups. Eo *icroconidida are seen. /he
or&anis* is:
1. Microsporu* canis
$. +pider*ophyton -occosu*
%. /richophyton ru#ru*
'. Microsporu* &ypseu*
(. /richophyton tonsurans
B
11
$
Seast: 1. Are 6la*entous fun&i
$. Are characteri;ed #y
tu#ular #ranchin& cells
%. 2or* fu;;y colonies
'. 2or* s*ooth colonies
(. Are unicellular o3al to
round cells that reproduce
#y #uddin& or 6ssion
).
+
11
%
A youn& &irl presented with a scaly
annular facial rash and alopecia of her
lower eyelashes. ,hich of the followin&
state*ents isare true. 1. A K9F prep and
fun&al culture *i&ht con6r* the dia&nosis.
$. /he etiolo&ic a&ent *i&ht #e
Microsporu* canis. %. /he fa*ily puppy
*i&ht #e infected. '. 5riseoful3in would #e
the dru& of choice. (. A topical a;ole
crea* would #e the dru& of choice.
1. 1:$:'
$. 1:$:%:'
%. 1:%:'
'. 1:$:(
(. 1:$:%:(
B
11
'
/his der*atophyte is not an anthropophilic
or&anis*:
1. /richophyton ru#ru*
$. +pider*ophyton -occosu*
%. Microsporu* &ypseu*
'. Microsporu* audouinii
(. /richophyton soudanense
C
11
(
A %! year"old *ale li3in& in the Chica&o
su#ur#s co*plained of a slowly &rowin&
3errucous plaLue with sharp #orders on
his left wrist. A #iopsy re3ealed yeast cells
1!"1' u*. Mucicar*ine was ne&ati3e. A
-uMy white colony &rew at roo*
te*perature ha3in& s*all round conidia
on thin conidiophores. /he dia&nosis is:
1. Blasto*ycosis
$. Cryptococcosis
%. Candidiasis
'. South A*erican
Blasto*ycosis
(. Fistoplas*osis
A
11
)
Medlar #odies are dia&nostic of infection
with which or&anis*.
1. Blasto*ycosis
$. Chro*o*ycosis
%. Coccidio*ycosis
'. Fistoplas*osis
(. Sporotrichosis
B
11
A
,hich of the followin& causes I#lack dot
rin&wor*I.
1. M. canis
$. /. 3iolaceu*
%. /. 3errucosu*
'. M. &ypseu*
B
1$)
(. M. auddouinii
11
C
All of the followin& are co**on causes of
chro*o#lasto*ycosis +OC+P/:
1. Cladosporiu* carrionii
$. Hhinocladiella aLuaspera
%. Phialophora 3errucosa
'. Pseudallescheria #oydii
(. 2onsecaea pedrosi
0
11
D
,hich of the followin& or&anis*s causes
fa3us.
1. /richophyton schoenleinii
$. /richophyton
*enta&rophytes
%. Microsporu* canis
'. /richophyton ru#ru*
(. Microsporu* distortu*
A
D. Pediatric 0er*atolo&y
# Question Answers Correc
t
Answe
r
1 ,hich treat*ent choice would #e
contraindicated in a one"year old
child who presents with
*ono*orphous: nonpruritic -at"
topped papules on the face:
#uttocks: e<tre*ities: pal*s and
soles.
1. Ad3il
$. Aceta*inophen
%. Fydration
'. Corticosteroids
(. 9#ser3ation
). Show +<plaination
0
$ ,hat is the *ost likely dia&nosis. 1. Psoriasis
$. Pityriasis rosea
%. Cutaneous /"cell ly*pho*a
'. Contact der*atitis
(. 8ichen planus
). Show +<plaination
0
% An infant who presents with this
a#nor*ality will often ha3e the
followin&:
1. /he lesion will #e on the left"
side in a se&*ental
distri#ution
$. Airway restriction
%. Fa3e *ultiple li3er
he*an&io*as
'. Most likely #e a *ale infant
(. An anterior fossa
*alfor*ation
). Show +<plaination
A
' 8ate onset su#un&ual keratotic
tu*ors are associated with:
1. 1ncontinentia pi&*enti
$. Eeuro6#ro*atosis /ype 1
%. Carney co*ple<
'. Cowden syndro*e
(. Basal cell ne3us syndro*e
). Show +<plaination
A
( PastiaJs lines are characteristic for
which eruption:
1. Measles
$. Scarlet fe3er
%. Hu#ella
'. KawasakiJs disease
(. Mu*ps
B
1$A
). Show +<plaination
) All four su#types of Phako*atosis
Pi&*ento3ascularis ha3e which
feature in co**on:
1. Ee3us spilus
$. +pider*al ne3i
%. Ee3us -a**eus
'. Ee3us ane*icus
(. 0er*al Melanocytosis.
). Show +<plaination
C
A ,hat is the #est treat*ent option. 1. 9ral cephale<in
$. 9ral acyclo3ir
%. 9#ser3ation
'. /opical tretinoin
(. /opical ketocona;ole
). Show +<plaination
0
C ?ariants of <eroder*a pi&*entosu*
are due to all of the followin& defects
e<cept:
1. Eucleotide e<cision repair
$. Felicase
%. +ndonuclease
'. /hy*idine kinase
(. Postrepliction repair
). Show +<plaination
0
D ,hich of the followin& can present
as collodion #a#y.
1. 1chthyosis 3ul&aris
$. O"linked ichthyosis
%. 8a*ellar ichthyosis
'. Bullous con&enital
ichthyosifor* erythroder*a
(. S4o&ren"8arsson syndro*e
). Show +<plaination
C
1! A ) *onth"old presents with oran&e"
#rown crusted plaLues around the
*outh and &roin. Se3eral #ullae are
present on the 6n&ers and toes.
,hich of the followin& la#oratory
3alues is likely to #e a#nor*al.
1. Fe*atocrit
$. Calciu*
%. Platelet count
'. A8/
(. Alkaline phosphatase
). Show +<plaination
+
11 Psa**o*atous *elanotic
schwanno*as are associated with:
1. Bloo* syndro*e
$. Carney co*ple<
%. Eeuro6#ro*atosis /ype 1
'. Eeuro6#ro*atosis /ype $
(. /u#erous sclerosis
). Show +<plaination
B
1$ ,hat is the #est test to con6r* a
dia&nosis.
1. 0s0EA anti#ody
$. Anti Ho anti#ody
%. Biopsy
'. K9F
(. 5ra* stain
). Show +<plaination
0
1% 7u3enile self"healin& papular
*ucinosis is associated with which of
the 6ndin&s.
1. Arthral&ias
$. Cataracts
%. /ype 1 dia#etes
'. Calcinosis cutis
(. Oeropthal*ia
). Show +<plaination
A
1' ,hich of the followin& clinical si&ns
is *ost likely associated.
1. Clitoral hypertrophy
$. Eeuro6#ro*as
%. A<illary frecklin&
'. Fypertrichosis
(. Alopecia
). Show +<plaination
A
1( A full ter* neonate is noted to ha3e
s*all pustules with no underlyin&
erythe*a present at deli3ery. /he
1. Miliaria
$. +rythe*a to<icu*
neonatoru*
C
1$C
pustules are easily re*o3ed with
clearin& of the 3erni< and a
collarette appears. A &ra* stain is
done showin& predo*inately
neutrophils without #acteria. ,hat is
the *ost likely dia&nosis.
%. /ransient neonatal pustular
*elanosis
'. Con&enital candidiasis
(. Brticaria pi&*entosa
). Show +<plaination
1) ,hat syndro*e is the disorder
shown in the photo associated with.
1. /urner syndro*e
$. 0own syndro*e
%. Eoonan syndro*e
'. 5riscelli syndro*e
(. Bloo* syndro*e
). Show +<plaination
C
1A A #oy is noted at #irth to ha3e
coarse scales o3er his trunk and
e<tre*ities. /he face: pal*s: soles
and -e<ures are spared. ,hat is the
least likely association.
1. Corneal opacities
$. Cryptorchidis*
%. +ctropion
'. Prolon&ed *aternal la#or
(. Eeurolo&ic a#nor*ality
). Show +<plaination
C
1C ,hat is the *ost likely dia&nosis. 1. Psoriasis
$. 8an&erhans cell histiocytosis
%. 5ranulo*a &luteale infantu*
'. Contact der*atitis
(. Perianal streptococcal
disease
). Show +<plaination
+
1D ,hat is the *ost co**on tu*or
associated with this condition.
1. /richo#lasto*a
$. SLua*ous Cell carcino*a
%. Se#aceous carcino*a
'. Basal cell carcino*a
(. /richoadeno*a
). Show +<plaination
A
$! JSlapped cheeksJ followed #y a
lacy eruption on e<tre*ities:
1. ss0EA 3irus
$. ds0EA 3irus
%. ssHEA 3irus
'. dsHEA 3irus
(. Streptococcus
). Show +<plaination
A
$1 A patient presents with an epider*al
ne3us of the lower a#do*en. Sou
take a skin #iopsy to con6r* the
dia&nosis. /he patholo&y report
indicates that there were 6ndin&s of
epider*olytic hyperkeratosis. ,hich
of the followin& defects is her
oMsprin& at risk for #ased on these
6ndin&s.
1. /rans&luta*inase
$. Keratin )a1)
%. Keratin )#1A
'. Keratin 11!
(. Keratin $e
). Show +<plaination
0
$$ Koplik spots typically appear: 1. Before the e<anthe*
$. At the sa*e ti*e as the
e<anthe*
%. 1 week after the e<anthe*
'. ) weeks after the e<anthe*
(. C weeks after the e<anthe*
). Show +<plaination
A
$% /his condition *ay #e associated
with which of the followin&:
1. Fypercalce*ia
$. Fyperlipide*ia
%. ?itili&o
'. +pider*olysis #ullosa
dystrophica
(. Perinatal trau*a
). Show +<plaination
0
1$D
$' An infant presents with the lesion
depicted in the photo. ,hich of the
followin& is least likely.
1. Sternal cleftin&
$. Suprau*#ilical raphe
%. 0andy",alker *alfor*ation
'. Sei;ure disorder
(. Con&enital cataracts
). Show +<plaination
0
$( An C year"old #oy presents with pink:
-ushed cheeks and a low"&rade
fe3er. 9n week later: the followin&
lacy eruption appeared. ,hat is the
*ost likely etiolo&y.
1. Para*y<o3irus
$. /o&a3irus
%. 5roup A streptococcus
'. FF?)
(. Par3o3irus
). Show +<plaination
+
$) ,hat is the *ost likely dia&nosis is
this 1) year old patient who
de3eloped &enerali;ed eruption $
weeks after onset of sore throat due
to strep infection.
1. Psoriasis
$. Pityriasis rosea
%. Cutaneous /"cell ly*pho*a
'. Contact der*atitis
(. 8ichen planus
). Show +<plaination
A
$A A youn& &irl presents with enlar&ed
ton&ue: e<o*phal*os: and
or&ano*e&aly and has history of
,il*Gs tu*or. ,hat cutaneous
6ndin& is *ost likely on physical
e<a*.
1. Pal*oplantar keratoder*a
$. 8y*phatic *alfor*ation
%. Acral ede*a
'. Midline capillary
*alfor*ation
(. An&iokerato*a
). Show +<plaination
0
$C ,hat is the *ost likely dia&nosis. 1. Psoriasis
$. 8an&erhans cell histiocytosis
%. Se#orrheic der*atitis
'. Contact der*atitis
(. Perianal streptococcal
disease
). Show +<plaination
A
$D P9+MS syndro*e is associated with
which of the followin&:
1. Pre*ature a&in&
$. 9donto&enic cysts
%. +ye a#nor*alities
'. M protein
(. Saddle nose defor*ity
). Show +<plaination
0
%! ,hich presentation of psoriasis is
*ore co**on in children:
1. Pustular psoriasis
$. Acroder*atitis continua of
Fallopeau
%. Keratoder*a #lennorra&ica
'. +rythroder*ic psoriasis
(. 5uttate psoriasis
). Show +<plaination
+
%1 ,hat is the *ost likely dia&nosis. 1. 1ncontinentia pi&*enti
$. Bullous pe*phi&oid of
infancy
%. Ferpes ;oster
'. 0isse*inated herpes si*ple<
(. +pider*olysis #ullosa
si*ple<
). Show +<plaination
A
%$ A % *onth"old &irl with *ultiple
he*an&io*as alon& her ri&ht 4aw is
at increased risk for:
1. Bleedin& co*plications
$. Bnderlyin& #one
a#nor*alities
%. Su#&lottic he*an&io*a
'. 9ral o#struction
(. Fearin& defecits
). Show +<plaination
C
1%!
%% ,hich of the followin& *ay #e
associated.
1. Paronychia
$. Cleft palate
%. A?M
'. Sei;ure disorder
(. Atrial septal defect
). Show +<plaination
0
%' ,hat is the #est therapeutic option. 1. 9ral cephale<in
$. /opical i**une *odulator
%. 9ral acyclo3ir
'. /opical *upirocin
(. 9ral prednisone
). Show +<plaination
C
%( Happ"Fod&kin is caused #y a defect
in the followin& &ene:
1. Plakophilin
$. 0es*o&lein 1
%. +ctodysplasin A
'. P)%
(. Conne<in %!
). Show +<plaination
0
%) An ei&ht year"old #oy presents with
pink: -ushed cheeks and a low"&rade
fe3er. +ruptions then appeared.
,hat is the *ost likely etiolo&y.
1. Para*y<o3irus
$. /o&a3irus
%. 5roup A streptococcus
'. FF?)
(. Par3o3irus
). Show +<plaination
+
%A ,hat de6ciency is responsi#le for
this condition.
1. /hia*ine
$. Eiacin
%. Kinc
'. ?ita*in C
(. ?ita*in A
). Show +<plaination
C
%C A new#orn presents with a pustular
rash: 4oint swellin&: oral *ucosal
lesions: and pain with *o3e*ent.
93er ti*e: cutaneous pustulosis:
ran&in& fro* discrete crops of
pustules to &enerali;ed se3ere
pustulosis and ichthyosifor* lesions
de3elop. 1n addition the new#orn
de3elops sterile *ultifocal
osteo*yelitis and periostitis. ,hat is
this condition.
1. Muckle",ells syndro*e
$. 0e6ciency of the interleukin"
1"receptor anta&onist =01HA>
%. 2a*ilial Mediterranean fe3er
'. Fyper"1&0 syndro*e
(. PAPA syndro*e
). Show +<plaination
B
%D ,hat is the dia&nosis. 1. Bnilateral laterothoracic
e<anthe*
$. Hoseola
%. Hu#ella
'. Brticaria
(. Contact der*atitis
). Show +<plaination
A
'! Pachyonychia con&enita type $ is
*ost co**only associated with
which of the followin&:
1. 1ncreased risk of *ali&nancy
$. Poikiloder*a
%. Eatal teeth
'. Aplastic nails
(. 0eafness
). Show +<plaination
C
'1 ,hat is the #est therapeutic option. 1. 9ral cephale<in
$. /opical i**une *odulator
%. 9ral acyclo3ir
'. /opical *upirocin
(. 9ral prednisone
). Show +<plaination
C
1%1
'$ Posterior auricular adenopathy is a
co**on feature of which e<anthe*:
1. Measles
$. Mu*ps
%. Scarlet fe3er
'. Hu#ella
(. +rythe*a infectiosu*
). Show +<plaination
0
'% C1) acti3atin& *utation in c"kit are
found *ost often in which su#set of
patients with *astocytosis.
1. Adults with syste*ic disease
refractory to i*antini#
$. Adults with syste*ic disease
associated with eosinophilia
%. Patients with fa*ilial history
of *astocytosis
'. Adults with /elan&iectasia
Macularis +rupti3a Perstans
(. As a *osaic *utation in
children with solitary
cutaneous *astocyto*a
). Show +<plaination
A
'' A de6ciency of the surface
&lycoprotein sialophorin is seen in
which i**unede6cient disease.
1. ,iskott"Aldrich syndro*e
$. Chronic &ranulo*atous
disease
%. 7o# syndro*e
'. Se3ere co*#ined
i**unode6ciency syndro*e
(. 8einerJs disease
). Show +<plaination
A
'( A healthy: full"ter* infant de3elops a
pustular: erythe*atous eruption on
her face and trunk on the third day
of life. A s*ear taken fro* one of
these pustules would show:
1. 5ra*"positi3e #acteria
$. Predo*inantly neutrophils
%. Multi"nucleated &iant cells
'. Predo*inantly eosinophils
(. Fyphae
). Show +<plaination
0
') ,hat is the *ost co**on tu*or
associated with this condition.
1. /richo#lasto*a
$. Syrin&ocystadeno*a
papilliferu*
%. Se#aceous carcino*a
'. Basal cell carcino*a
(. /richoadeno*a
). Show +<plaination
A
'A Multiple cylindro*as are associated
with:
1. Myotonic dystrophy
$. Cowden syndro*e
%. Carney co*ple<
'. /richoepithelio*as
(. Pilo*atricho*as
). Show +<plaination
0
'C ,hat is the *ost likely dia&nosis. 1. Papular acroder*atitis of
childhood
$. Mucocutaneous ly*ph node
syndro*e
%. 5er*an *easles
'. 8etterer"Siwe disease
(. +<anthe* su#itu*
). Show +<plaination
A
'D 1n a child with ;inc de6ciency: yet
nor*al or near nor*al ;inc le3els:
which test could #e a 3alua#le
ad4uncti3e test.
1. Ma&nesiu*
$. Eiacin
%. Man&anese
'. Alkaline phosphatase
(. 1ron
). Show +<plaination
0
(! A 1! year old &irl presents with 1. Henal ultrasound B
1%$
desLua*ation of the 6n&ertips.
,hich e<a* should #e ordered.
$. AS9 titer
%. ++5
'. +ye e<a*
(. Chest <"ray
). Show +<plaination
(1 A )"year"old #oy presents with
osteo*a cutis on his face. ,hich of
the followin& &enes is *ost likely
defecti3e.
1. 5EAS
$. ES0F8
%. P/+E
'. SP1EK(
(. S8BHP1
). Show +<plaination
A
($ 9steopathia striata is found in which
disorder.
1. McCune"Al#ri&ht syndro*e
$. Eeuro6#ro*atosis 1
%. Buschke"9llendorM syndro*e
'. 5orlinGs syndro*e
(. 2ocal der*al hypoplasia
). Show +<plaination
+
(% /his patient had si&ni6cantly
ele3ated seru* CPK. /he likely
dia&nosis is:
1. 0er*ato*yositis
$. 8upus erythe*atosus
%. Psoriasis
'. Atopic der*atitis
(. 8ichen planus
). Show +<plaination
A
(' /he causati3e a&ent of Hoseola is: 1. A ss0EA 3irus
$. A ds0EA 3irus
%. A ssHEA 3irus
'. A dsHEA 3irus
(. Streptococcus
). Show +<plaination
B
(( Eeonatal acne is associated with
species of which or&anis*:
1. Staphylococcus
$. Propioni#acteriu*
%. Candida
'. Malasse;ia
(. Streptococcus
). Show +<plaination
0
() A patient presents with *ultiple
4u3enile <antho&ranulo*as: a<illary
frecklin&: *ultiple cafJ"au"lait
*acules: three neuro6#ro*as and a
fa*ily history of E2"1. ,hat other
condition is this patient at increased
risk for.
1. AM8
$. CM8
%. C88
'. Medullo#lasto*a
(. Pancreatic carcino*a
). Show +<plaination
B
(A An infant presents with the lesion
depicted in the photo. ,hat
infor*ation do you pro3ide the
parents re&ardin& this condition.
1. /he lesion will &o throu&h
rapid &rowth followed #y
sta#ili;ation and re&ression
$. /he lesion will respond to
laser therapy
%. /he lesion will persist and
*ay &row further
'. /he lesion will resol3e with
antifun&al therapy
(. /he lesion is associated with
a O9 karyotype
). Show +<plaination
C
(C /he lesion depicted is *ost often
associated with:
1. Polyostotic 6#rous dysplasia
$. Chondrodysplasia punctata
%. Sphenoid win& hypoplasia
'. Cleft palate
(. 9steopoikilosis
). Show +<plaination
A
1%%
(D ,hich of the followin& #ullous
disorders is due to a tar&et anti&en
that is a DA k0 protein which is a
*e*#er of BPA5"$.
1. Bullous 0er*olysis of the
Eew#orn
$. Eeonatal Pe*phi&us
%. 8inear 1&A Bullous
0er*atosis
'. 7unctional epider*olysis
#ullosa =Ferlit;>
(. +pider*olysis #ullosa
si*ple<
). Show +<plaination
C
)! ,hat is the *ost co**on cause of
neonatal purpura ful*inans.
1. Strep
$. Staph
%. ?aricella
'. Protein C de6ciency
(. 2actor ? 8eiden de6ciency
). Show +<plaination
0
)1 A new#orn infant presents with rin&
of lon&: dark: coarse hair
surroundin& a *idline scalp patch of
alopecia. ,hat is associated with
this 6ndin&.
1. Alopecia areata
$. +ctopic #rain tissue
%. /hyroid disease
'. Ee3us se#aceus of 7adassohn
(. 0eafness
). Show +<plaination
B
)$ Schi**elpennin&"2euerstein"Mi*s
syndro*e *ay #e associated with
which of the followin&:
1. 9steopokilosis
$. Polyostotic 6#rous dysplasia
%. 9steopathia striata
'. Chondrodysplasia punctata
(. Fypophosphate*ic rickets
). Show +<plaination
+
)% /he risk of fetal death with
intrauterine par3o3irus infection *ay
occur with infection in which
tri*ester:
1. 2irst
$. Second
%. /hird
'. 2irst: Second and /hird
(. Eone of these answers are
correct
). Show +<plaination
0
)' /he standard of care of patients with
acute KawasakiJs disease is:
1. Prednisone
$. Supporti3e care
%. Aspirin and 1?15
'. Penicillin
(. Aceta*inophen and 1?15
). Show +<plaination
C
)( A neonate presents with a lar&e
se&*ental he*an&io*a of the ?1
distri#ution. ,hat are features *ay
#e associated with this 6ndin&.
1. /ra*"track calci6cations
$. Anterior fossa defect
%. Posterior fossa defect
'. M"paraproteine*ia
(. Muscular dystrophy
). Show +<plaination
C
)) A child presents with hi&h fe3er:
straw#erry ton&ue:
ly*phadenopathy: and a
poly*orphous e<anthe*.
Appro<i*ately how *any of these
patients will ha3e coronary artery
aneurys*s if left untreated.
1. /wo percent
$. 2i3e percent
%. /en percent
'. /wenty"63e percent
(. Si<ty percent
). Show +<plaination
0
)A ,hat syndro*e can accessory tra&i
#e associated with.
1. 5oldenhar syndro*e
$. /urner syndro*e
%. Eeuro6#ro*atosis
'. 1chthyosis
(. Birt Fo&& 0u#e
). Show +<plaination
A
1%'
)C ,hich of the followin& disorders is
*ore likely to occur in children with
chronic fecal incontinence.
1. 8an&erhans cell histiocytosis
$. Perianal pseudo3errucous
papules and nodules
%. Perianal streptococcal
disease
'. 5ranulo*a &luteale infantu*
(. Se#orrheic der*atitis
). Show +<plaination
B
)D ,hat the *ost likely dia&nosis. 1. Atopic der*atitis
$. 8a*ellar ichthyosis
%. Hud syndro*e
'. ,iskott"Aldrich syndro*e
(. Keratosis pilaris
). Show +<plaination
A
A! Menkes kinky hair syndro*e is
associated *ost co**only with:
1. /richorrhe<sis in3a&inata
$. /richostasis spinulosa
%. Pili *ulti&e*ini
'. Pili torti
(. Plica neuropathica
). Show +<plaination
0
A1 ,hat is the *ost likely dia&nosis. 1. /raction alopecia
$. /inea capitis
%. Aplasia cutis con&enita
'. Ee3us se#aceous
(. Alopecia areata
). Show +<plaination
C
A$ ,hich of the followin& should #e the
ne<t step in the *ana&e*ent of this
patient.
1. Bariu* swallow
$. spine <"ray
%. Cardiac e3aluation
'. Ad*inistration of oral
anti#iotics
(. Pul*onary function studies
). Show +<plaination
C
A% A $ day"old full ter* neonate
de3elops #lotchy erythe*atous
*acules with s*all central pustules
o3er the upper trunk and
e<tre*ities. A &ra* stain re3eals
predo*inantly eosinophils. ,hat is
the *ost likely dia&nosis.
1. +rythe*a to<icu*
neonatoru*
$. 1ncontinentia pi&*enti
%. Brticaria pi&*entosa
'. /ransient neonatal pustular
*elanosis
(. Miliaria
). Show +<plaination
A
A' A youn& #oy presents with a port"
wine stain: a Mon&olian spot: and a
ne3us spilus. ,hich phako*atosis
pi&*ento3ascularis does he ha3e.
1. /ype 1
$. /ype 11
%. /ype 111
'. /ype 1?
(. /ype ?
). Show +<plaination
0
A( A new#orn has a nodule o3er his
lu*#ar spine. Skin #iopsy re3eals a
lipo*a. /he ne<t appropriate step is:
1. 9#ser3ation
$. +<cision of the lesion
%. 5enetic testin&
'. 1*a&in& study
(. Mali&nancy work up
). Show +<plaination
0
A) ,hich 6ndin& is associated with
Pachyder*operiostosis:
1. Cutis 3erticis &yrata
$. Pal*oplantar hyperkeratosis
%. Mucosal keratoses
'. 9steopathia striata
(. Cutis *ar*orata
). Show +<plaination
A
1%(
AA Most co**on location of cutaneous
lesions in neonatal lupus
erythre*atosus is
1. Cheeks
$. Eose
%. Scalp
'. Perioral
(. Perior#ital
). Show +<plaination
+
AC ,hich of the followin& is *ost likely
associated.
1. Eo additional a#nor*ality
$. 0eafness
%. Coarctation of the aorta
'. Bi6d ri#
(. Alopecia
). Show +<plaination
A
AD ,hat disorder is associated with a
defect in 8MO1B.
1. Eail patella syndro*e
$. Steatocysto*a
%. Monilithri<
'. 8her*itte"0uclos syndro*e
(. Chediak"Fi&ashi syndro*e
). Show +<plaination
A
C! ,hich of the followin& is
characteristic of ,ooly Fair Ee3us:
1. /ypically occurs in the (th
decade
$. 9cular a#nor*alities *ay #e
associated
%. /here are no ne3i associated
with this hair a#nor*ality
'. Sponteneous i*pro3e*ent
ne3er occurs
(. 1t is hereditary
). Show +<plaination
+
C1 ,hich of followin&s syndro*es
characteri;ed #y Se#orrheic"like or
e<foliati3e der*atitis
1. 8einerGs disease
$. Fyperi**uno&lo#uline*ia +
syndro*e
%. ,iskott"Aldrich syndro*e
'. Chronic &ranulo*atous
disease
(. O"linked
a&a**a&lo#uline*ia
). Show +<plaination
A
C$ ,hich of the followin& is not a *a4or
criterion for KawasakiJs disease:
1. 2e3er `( days
$. Pal*oplantar erythe*a `
desLua*ation
%. Cardiac aneurys*
'. Straw#erry ton&ue red lips
(. Cer3ical adenopathy
). Show +<plaination
C
C% /richothiodystrophy classically
includes which of the followin&
6ndin&s:
1. /richostasis
$. /richoschisis
%. Pili torti
'. /richorrhe<is in3a&inata
(. /richorrhe<is nodosa
). Show +<plaination
B
C' /he *ost co**on a&e &roup for
papular"purpuric &lo3es and socks
syndro*e is:
1. Eew#orns
$. /oddlers
%. )"1! year olds
'. Adolescents
(. +lderly
). Show +<plaination
0
C( ,hich of the followin& is the *ost
co**on co*plication associated
with cutis *ar*orata telan&ectatica
con&enita.
1. Sei;ure disorder
$. Atrial septal defect
%. Syste*ic lupus
erythe*atosus
+
1%)
'. Fypercalce*ia
(. 8i*# hypertrophy or atrophy
). Show +<plaination
C) A ' *onth"old with diMuse #listers
and erosions has a skin #iopsy
dia&nostic of &enerali;ed
*astocytosis. ,hich topical dressin&
should #e a3oided in this patient.
1. Mupirocin oint*ent
$. Poly*y<in B oint*ent
%. Petrolatu*
'. Eeo*ycin oint*ent
(. Sil3er sulfadia;ine
). Show +<plaination
B
CA /he Carney co*ple< is associated
with a defect in:
1. PHKAH1A
$. 8SS/
%. P/+E
'. MASF$
(. M8F1
). Show +<plaination
A
CC /he association of Port"wine stains
on a li*# with soft tissue swellin&
with or without #ony o3er &rowth is:
1. Bannayan"Hiley"Hu3alca#a
syndro*e
$. 5oldenharGs syndro*e
%. Stur&e",e#er syndro*e
'. Klippel"/renaunay syndro*e
(. Proteous syndro*e
). Show +<plaination
0
CD A $ year"old has a hi&h fe3er for
three days: as the fe3er #reaks: a
&enerali;ed rash appears on the
trunk. /he *ost likely dia&nosis is:
1. Measles
$. Mu*ps
%. Hu#ella
'. +rythe*a infectiosu*
(. Hoseola
). Show +<plaination
+
D! An infant with failure to thri3e has
*ultiple <antho*as on skin e<a*
and foa*y histiocytes on #one
*arrow #iopsy. Sour dia&nosis is:
1. 5aucherJs disease
$. /ay"SachJs disease
%. Eie*ann"Pick disease
'. 2a#ryJs disease
(. FunterJs syndro*e
). Show +<plaination
C
D1 ,hat is the function of the &ene
which is defecti3e in ata<ia"
telan&iectasia.
1. 5ap 4unction protein
$. Cross"linkin& of structural
proteins in the protein and
lipid en3elope of the upper
epider*is
%. Pathway of cholesterol
#iosynthesis
'. 0EA repair protein
(. /u*or supressor protein
). Show +<plaination
0
D$ A $' *onth"old infant presents with
yellowish"#rown: crusted papules
with petechiae in a se#orrheic
distri#ution. A #iopsy is done to
con6r* a dia&nosis. ,hich histolo&ic
picture is *ost likely.
1. C01": S1!!" cells with
renifor* nuclei
$. 2oa*y histiocytes with
/outon &iant cells
%. C01P: S1!!P cells with
renifor* nuclei
'. Mi<ed cellular in6ltrate in a
J#all and clawJ pattern
(. Super6cial peri3ascular
in6ltrate with *ild spon&iosis
and neutrophil containin&
scale crust
). Show +<plaination
C
D% ,hich of the followin& is the *ost
co**on lon& ter* seLuelae fro*
con&enital ru#ella syndro*e.
1. Macrocephaly
$. Sa#er shins
%. 0eafness
C
1%A
'. Eysta&*us
(. Microcephaly
). Show +<plaination
D' ,hich of the followin& is not true
a#out 5ianotti"Crosti.
1. 1t is associated with 3iral
infections like enterocirus:
+B?: and CM?
$. 1t typically aMects children
#etween the a&e of % *onths
and 1( years
%. 1t is characteri;ed #y
*ono*orphic sy**etric -at
topped papules in acral areas
'. 1t *ay ha3e associated
fe3ers: ly*phadenopathy:
and diarrhea
(. Corticosteroids should #e
&i3en to alle3iate the
pruritus of the lesions
). Show +<plaination
+
D( 58B/"1 stains placental tissue. ,hat
other tissue shows positi3e 58B/"1
stainin&.
1. capillary 3ascular
*alfor*ation
$. sal*on patch
%. &lo*us tu*or
'. infantile he*an&io*a
(. an&elGs kiss
). Show +<plaination
0
D) ,hat is the *ost likely dia&nosis: 1. +pider*olysis #ullosa
si*ple<
$. +pider*olysis #ullosa
dystrophica
%. Pe*phi&us 3ul&aris
'. 8inear #ullous 1&A disease
(. 2acticial der*atosis
). Show +<plaination
A
DA An infant presents with yellowish"
#rown: crusted papules with
petechiae in a se#orrheic
distri#ution. ,hich of the followin&
state*ents a#out this entity is likely
to #e true.
1. /his presentation is
consistent with 7acLuetGs
der*atitis
$. C01P: S1!!P cells with
co**a"shaped nuclei should
#e seen on #iopsy
%. /his presentation occurs
when the infant is weaned
oM of #reast *ilk
'. An autoso*al recessi3e
defect in holocar#o<ylase
synthetase is the cause
(. Maternal"fetal trans*ission
*ost likely occured in the
peripartu* period
). Show +<plaination
B
DC Su#cutaneous fat necrosis of the
new#orn is usually treated with:
1. Aspirin
$. /opical calcipitriol
%. +<cision
'. 9#ser3ation
(. Hetinoids
). Show +<plaination
0
DD A $ week"old infant is #rou&ht to the
+H with a rash on her face. She is
found to ha3e a %rd de&ree heart
#lock. ,hat is the risk that a second
1. (N
$. 1!N
%. $(N
'. (!N
C
1%C
child #orn to this *other will ha3e
the sa*e dia&nosis.
(. 1!!N
). Show +<plaination
1!
!
A % *onth old #a#y &irl is #rou&ht to
your oTce for consultation. Sou note
an infantile he*an&io*a on the tip
of the nose. 1*a&in& re3eals no
underlyin& structural ano*alies in
the cere#ro"3asculature. Sou discuss
startin& propranolol. ,hat side eMect
do you need to *onitor for.
1. Fypertension
$. Fypercalce*ia
%. Fypo&lyce*ia
'. /achycardia
(. Fypernatre*ia
). Show +<plaination
C
1!
1
1ndi3iduals with which of the
followin& syndro*es
characteristically present with
photosensiti3ity: *ental retardation:
a Iwi;enedI appearance: I#ird"
headedI facies: and IMickey MouseI
ears.
1. /ay Syndro*e
$. Hoth*und"/ho*son
Syndro*e
%. Futchinson"5ilford Pro&eria
Syndro*e
'. Cockayne Syndro*e
(. ,erner Syndro*e
). Show +<plaination
0
1!
$
,hich of the followin& is a potential
co*plication of su#cutaneous fat
necrosis of the new#orn.
1. Cholestrol clefts in fat cells
$. Fypercalce*ia
%. Acute renal failure
'. Fepatitis
(. +le3ated uric acid le3els
). Show +<plaination
B
1!
%
/he &enetic disorder depicted in this
photo is caused #y a *utation in:
1. MASF$
$. S/K11
%. P/+E
'. Patched
(. /SC1
). Show +<plaination
B
1!
'
,hich of the followin& is a ss0EA
3irus:
1. Ferpes3irus
$. Par3o3irus
%. Picorno3irus
'. Adeno3irus
(. Parapo<
). Show +<plaination
B
1!
(
,hat is the dia&nosis. 1. /ransient neonatal pustular
*elanosis
$. Acropustulosis of infancy
%. Eeonatal cphalic pustulosis
'. Miliaria
(. +rythe*a to<icu*
neonatoru*
). Show +<plaination
C
1!
)
A full ter* new#orn de3elops
erythe*atous: indurated plaLues on
the upper #ack. ,hich of the
followin& tests should #e perfor*ed.
1. Calciu*
$. Co*plete #lood count
%. Blood culture
'. /hyroid function test
(. Alkaline phosphatase
). Show +<plaination
A
1!
A
/he diMerential dia&nosis of ;inc
de6ciency is least likely to include:
1. 5ranulo*a &luteale infantu*
$. Biotin de6ciency
%. Multiple car#o<ylase
de6ciency
'. Cystic 6#rosis
(. Folocar#o<ylase synthetase
de6ciency
). Show +<plaination
A
1!
C
,hich of the followin& is a si&n of
+AH8S postnatal con&enital syphilis.
1. CluttonGs 4oints
$. Fi&ou*enakiGs si&n
+
1%D
%. FutchinsonGs teeth
'. Sa#er shins
(. ,i*#er&erGs si&n
). Show +<plaination
1!
D
/he *ost likely etiolo&y of
7acLuetJs diaper der*atitis is:
1. Candida
$. /richophyton ru#ru*
%. 5roup A #eta"he*olytic
streptococcus
'. Ferpes si*ple< 3irus: /ype $
(. Multifactorial
). Show +<plaination
+
11
!
Most co**on *ali&nancy
associated with *ultiple lesions
si*ilar to the attached i*a&e is:
1. Acute *yelo&enous leuke*ia
$. Chronic *yelo&enous
leuke*ia
%. Acute ly*phocytic leuke*ia
'. Chronic ly*phocytic
leuke*ia
(. Melano*a
). Show +<plaination
B
11
1
,hich of the followin& diseases with
i**unode6ciency has an increased
risk of ly*phoreticular *ali&nancy.
1. ,iskott"Aldrich syndro*e
$. Chronic &ranulo*atous
disease
%. 7o# syndro*e
'. Se3ere co*#ined
i**unode6ciency syndro*e
(. 8einerJs disease
). Show +<plaination
A
11
$
Ankylo#lepharon 6lifor*e adnatu* is
seen with a defect in:
1. Plakophilin
$. Plako&lo#in
%. 0es*o&lein
'. C"kit
(. p)%
). Show +<plaination
+
11
%
An infant presents with red"purple:
&ranulo*atous nodules occurrin& in
the diaper area. /he etiolo&y is
secondary to local irritation:
*aceration and Candida al#icans.
,hat is the *ost likely dia&nosis.
1. 5ranulo*a &luteale infantu*
$. 8an&erhans cell
histiocytosisc.
%. Se#orrheic der*atitis
'. Biotin de6ciency
(. Psoriasis
). Show +<plaination
A
11
'
A new#orn presents with a well"
de6ned: shiny patch with co*plete
alopecia on the 3erte< of the scalp
alon& the suture lines. ,hich of the
followin& is the 6rst step in
dia&nosis.
1. MH1
$. Calciu*
%. Skin #iopsy
'. Skull <"ray
(. 2un&al culture
). Show +<plaination
0
11
(
Hhinorrhea: condylo*ata lata: and
*ucous patches are all seen with
which con&enital disorder.
1. Hu#ella
$. /o<oplas*osis
%. Ferpes si*ple< 3irus
'. Syphilis
(. Fu*an papillo*a3irus
infection
). Show +<plaination
0
11
)
,hich enanthe* is *ost co**only
seen in association with +<anthe*
su#itu*.
1. Koplik spots
$. Hed straw#erry ton&ue
%. Chapped lipsc dry: red
*ucosa
'. Hed *acules and streaks on
the soft palate
(. Palatal erosions
0
1'!
). Show +<plaination
11
A
/he disorder caused #y a defect in
intestinal ;inc"speci6c transporter
S8C%DA' is *ost likely to present:
1. At #irth
$. Bpon weanin& fro* #reast
*ilk
%. Bpon weanin& fro* for*ula
'. 1n childhood
(. 1n adulthood
). Show +<plaination
B
1!. Cutaneous Manifestations of Syste*ic 0isease
# Question Answers Corre
ct
Answ
er
1 /he patient de*onstrated in 6&ure ) 1. 808 receptor de6ciency C
1'1
would ha3e: $. 0ecreased chylo*icrons
%. +le3ated tri&lycerides
'. 0ecreased 808
(. 0ecreased tri&lycerides
).
$ ,hich of the followin& is true
re&ardin& pie#aldis*.
1. 1t is caused #y a *utation in
the 57B$ &ene
$. 1t is caused #y defecti3e
*eta#olis* of phytanic acid
%. 1t is caused #y a defect in a
protein su#unit of a kinase that
acti3ates E2kappaB
'. 1t is caused #y a de6ciency of
fatty aldehyde dehydro&enase
(. 1t is caused #y a *utation in
the proto"onco&ene c"K1/
).
+
% ,hat is the *ost co**on internal
cause of intracta#le pruritus.
1. Fepatitis C
$. Fypothyroidis*
%. Fyperthyroidis*
'. Chronic renal failure
(. 1nternal *ali&nancy
).
0
' Porphyria cutanea tarda *ay #e
associated with all of the followin&
e<cept:
1. Fepatitis C 3irus infection
$. Alcohol
%. +stro&ens
'. Polyhalo&enated hydrocar#ons
(. 1nherited de6ciency of
uroporphyrino&en 111 synthase
).
+
( ,hich of the followin& state*ents
a#out *ultiple endocrine neoplasia
=M+E> syndro*es is 2A8S+.
1. M+E 1 is associated with
an&io6#ro*as and colla&eno*as
$. M+E 11a is related to a defect
in H+/ proto"onco&ene
%. M+E 11a and 11# are #oth
associated with *edullary thyroid
carcino*a
'. M+E 1: 11a and 11# are all
inherited in an autoso*al
do*inant fashion
(. M+E 11a is associated with
*ultiple *ucosal neuro*as
).
+
) A (!"year old wo*an with a history
of spontaneous pneu*othora<
de3elops *ultiple 6r*: skin colored
lesions on her face and neck o3er a
period of se3eral years. /his patient
should ha3e periodic sur3eillance for
the de3elop*ent of:
1. Henal Cell Carcino*a
$. 5astric Carcino*a
%. Breast Carcino*a
'. 93arian Carcino*a
(. 8un& Carcino*a
).
A
A ,hich of the followin& is true
re&ardin& cutaneous associations
with hepatitis C 3irus =FC?> infection.
1. +rosi3e *ucosal lichen planus
has a weaker association with FC?
than does cutaneous lichen planus
$. Pruritus in the settin& of
chronic FC? infection is &enerally
correlated with ele3ated #ile salt
le3els in the settin& of li3er failure
%. Polyarteritis nodosa is
associated with FC? infection #ut
not hepatitis B 3irus infection
0
1'$
'. FC?"related porphyria cutanea
tarda *ay #e caused #y
deco*part*entali;ation of iron
stores and resultant o<idation of
uroporphyrino&en decar#o<ylase
(. Cutaneous reactions to FC?
treat*ent are less co**on with
interferonri#a3irin co*#ination
treat*ent than with treat*ent with
interferon alone
).
C ,hich of the followin& state*ents
re&ardin& porphyrias is /HB+.
1. +le3ated uroporphyrins are
found in the red #lood cells of
hepatoerythropoietic porphyria
$. 0elta a*inole3ulenic acid is
the only o<idi;ed porphyrin
%. Acute inter*ittent porphyria is
the *ost co**on for* of
porphyria
'. 5riseoful3in is safe for those
with 3arie&ate porphyria
(. Plas*a -uoresces at '1! n*
in patients with 3arie&ate
porphyria
).
B
D ,hich of the followin& la#oratory
a#nor*alities is *ost co**on in
patients with cholesterol e*#oli.
1. Eeutrophilia
$. +le3ated a*ylase
%. Fypercalce*ia
'. +osinophilia
(. Ane*ia
).
0
1! A patient presents with episodic
-ushin& of the face and neck:
a#do*inal pain: whee;in&: cou&h:
and diarrhea. Carcinoid syndro*e is
suspected. ,hich of the followin&
tests would con6r* the dia&nosis.
1. Chan&e of urine to &reen color
upon addition of nitrosonaphthol
$. +le3ated urinary ("
hydro<yindolacetic acid
%. +le3ated $'"hour urine
norepinephrine
'. 0ecreased $'"hour urine
3anilyl*andelic acid
(. +le3ated seru* tryptase
).
B
11 A youn& African A*erican patient
presents with ane*ia and
spontaneously appearin& le& ulcers
o3er #oth lateral and *edial *alleoli.
/he *ost likely dia&nosis is:
1. Atherosclerotic disease
$. Sickle cell ane*ia
%. 2actitial der*atitis
'. 8upus erythe*atosus
(. /rau*a
).
B
1$ ,hen *etastases to the skin occur
fro* a thyroid *ali&nancy: they are
usually due to:
1. Medullary carcino*a
$. Papillary adenocarcino*a
%. 2ollicular carcino*a
'. Anaplastic carcino*a
(. Cutaneous *etastases ha3e
not #een reported in association
with thyroid *ali&nancies
).
B
1% /he or&anis* that causes this
infection shown in the 6&ure is:
1. /. tonsuran
$. C. i**itis
%. C. al#icans
'. P. aeru&inoas
(. /. 3errucosu*
C
1'%
).
1' ,hich of the followin& is true a#out
#lue ru##er #le# ne3us syndro*e.
1. typically appears in adulthood
$. the 3enous *alfor*ations
re&ress with ti*e
%. characteri;ed #y co*pressi#le
#lue nodules !.1 to ( c* in si;e.
'. the nodules are pruritic
(. the &astrointestinal lesions are
typically located in the sto*ach
).
C
1( Fypothyroidis* *ay result in all of
the followin& cutaneous 6ndin&s
e<cept:
1. 1ncrease in the percenta&e of
telo&en hairs
$. Sellowish hue
%. Purpura
'. Madarosis
(. All of these answers are
correct
).
+
1) +ach of the followin& de*onstrates a
3asculitis e<cept:
1. 5ranulo*a faciale
$. Fenoch"Schoenlein purpura
%. /ype 1 cryo&lo#uline*ia
'. ,e&enerJs &ranulo*atosis
(. 8eukocytoclastic 3asculitis
).
C
1A ,hich of the followin& state*ents
a#out necrolytic *i&ratory erythe*a
is /HB+.
1. /here is a low incidence of
*etastasis of the oMendin& tu*or
at the ti*e of dia&nosis
$. Acanthosis and parakeratosis
are found on routine histolo&y
%. Seru* &luca&on le3els are
usually nor*al
'. ?acuolar chan&es are nor*ally
found on routine histolo&y
(. /he oMendin& tu*or ori&inates
fro* endocrine ar&entaTn cells
).
B
1C ,hich of the followin& syndro*es
necessitates a work"up for colon
cancer.
1. /urcot
$. Birt"Fo&&"0u#e
%. 8AMB
'. Muckle ,ells
(. ,ells
).
A
1D A $!"year"old *ale de3elops an
eruption of 1!!Gs of red"#rown
yellowish papules with in3ol3e*ent
of the *ucous *e*#ranes. Fe has
no ly*phadenopathy. /he *ost likely
dia&nosis is:
1. Mont&o*eryGs syndro*e
$. Beni&n cephalic histiocytosis
%. Hosai"0orf*an disease
'. Eecro#iotic <antho&ranulo*a
(. Multicentric
reticulohistiocytosis
).
A
$! All of the followin& are true re&ardin&
Fenoch"Schonlein Purpura +OC+P/:
1. 1t is an 1&5 *ediated s*all
3essel 3asculitis
$. 0irect i**uno-uorescence of
lesional and peri"lesional skin will
de*onstrate C% and 6#rin deposits
in s*all 3essel wall
%. 1t is often preceded #y an
upper respiratory infection
'. 1t *ay #e co*plicated #y
intussusception
(. 1t is self"resol3in&
A
1''
).
$1 ,hich of the followin& is E9/
nor*ally associated with
der*ato*yositis.
1. 93arian cancer in wo*en
$. Psoriasifor* der*atitis of the
scalp
%. +le3ated aldolase le3els
'. Cuticular dystrophy
(. /esticular cancer in *en
).
+
$$ 9ne *i&ht see all of the followin&
la#oratory and clinical a#nor*alities
in cryo&lo#uline*ia associated with
hepatitis C 3irus infection +OC+P/:
1. +le3ated li3er function tests
$. Positi3e rheu*atoid factor
%. +le3ated C% le3els
'. Acrocyanosis
(. Brticarial plaLues
).
C
$% He&ardin& carcinoid syndro*e: which
of the followin& is /HB+.
1. Sy*pto*s are caused #y
*etastases to the skin
$. /he *ost co**on location for
the tu*or is the rectu*
%. So*atostatin is a preferred
treat*ent
'. ?MA is ele3ated in the urine
(. /he tu*ors should not #e
re*o3ed
).
C
$' A patient de3elops cold"e<acer#ated
dusky acral plaLues consistent with
pernio. /he syste*ic condition *ost
likely to *anifest such lesions is:
1. 8upus +rythe*atosus
$. 0er*ato*yositis
%. AcLuired 1**unode6ciency
Syndro*e
'. Fepatitis C
(. 0ia#etes Mellitus
).
A
$( All of the followin& disorders ha3e an
increased risk of syste*ic
*ali&nancy e<cept
1. Hoth*und /ho*pson
syndro*e
$. Cockayne syndro*e
%. Bloo* syndro*e
'. ,erner syndro*e
(. Oeroder*a pi&*entosu*
).
B
$) An unco**on co*plication of
treat*ent with potassiu* iodide is:
1. Acute &enerali;ed
e<anthe*atous pustulosis
$. +rythe*a nodosu*
%. ,olM"ChiakoM eMect
'. +<acer#ation of lichen planus
(. Fyperhidrosis
).
C
$A All of the followin& are true re&ardin&
the condition pictured +OC+P/:
1. Perilesional direct
i**uno-uroescence shows
&ranular 1&A in the der*al papillae
and at the der*oepider*al
4unction
$. 9nly $!N of patients ha3e a
&luten"sensiti3e enteropathy
%. 1t is associated with F8A"0Q$:
F8A"0H%: and F8A"BC
'. 1t is associated with
Fashi*otoGs thyroiditis
(. Cutaneous 6ndin&s are due to
autoanti#odies to epider*al
trans&luta*inase
).
B
1'(
$C ,hat is the *ost co**on pri*ary
site of a carcinoid tu*or.
1. 8i3er
$. Sto*ach
%. Appendi<
'. 0uodenu*
(. 1leu*
).
C
$D All of the followin& state*ents are
true re&ardin& this condition +OC+P/:
1. 0ia#etes or &lucose
intolerance is found in $!N of
these patients
$. /his condition *ay #e
associated with cutaneous
anesthesia: hypohidrosis: and
partial alopecia
%. /here is no i*pact of ti&ht
&lucose control on the likelihood of
de3elopin& this condition
'. !.%"%N of dia#etics ha3e this
skin condition
(. /his condition is associated
with increased der*al *ucin
).
+
%! A patient with &astric cancer
de3elops acanthosis ni&ricans and a
sudden eruption of nu*erous warty
stuck"on papules on the trunk. ,hat
other 6ndin& *ay #e seen.
1. Eu*erous wart"like lesions on
the dorsal hands and wrists
$. 2ollicular spicules on the nose
%. Carpal tunnel syndro*e
'. Perior#ital pupura
(. Mi&ratory thro*#ophle#itis
).
A
%1 A patient presents with a co*plaint
of facial -ushin& that spreads to the
neck and upper trunk. He3iew of
syste*s re3eals that the patient has
occassional #outs of diarrhea: and
inter*ittent #ronchospas*.
8a#oratory testin& re3eals an
ele3ated urine ("hydro<yindole"acetic
acid le3el. ,hich of the state*ents
re&ardin& this condition is E9/
correct.
1. Chest and a#do*inalpel3ic C/
scannin& should #e the ne<t step
in this patientGs e3aluation
$. /he patient *ay ha3e an
associated scleroder*oid"like
eruption on e<a*ination
%. /he patient likely has a
neoplas* ori&inatin& in the
endocrine ar&entaTn cells
'. /reat*ent with
cyproheptadine would #e
contraindicated
(. /he patient likely has a
neoplas* located in the 51 tract
).
0
%$ A patient presents with planepal*ar
<antho*as. /he *ost likely &enetic
disorder would #e:
1. fa*ilial lipoprotein lipase
de6ciency
$. 2a*ilial hypertri&lyceride*ia
%. 2a*ilial hypercholesterole*ia
'. 2a*ilial
dys#etalipoproteine*ia
(. Cere#rotendinous
<anto*atosis
).
0
%% Mutations in the S/K11 &ene
encodin& a serine threonine kinase
are seen in:
1. Muir"/orre Syndro*e
$. Bannayan"Hiley"Hu3alca#a
Syndro*e
%. Birt"Fo&&"0u##e Syndro*e
'. Cronkhite"Canada Syndro*e
(. Peut;"7e&hers Syndro*e
).
+
%' A patient presents with *ild *ental 1. /his syndro*e is inherited in +
1')
retardation: infertility: 4oint
contractures: short stature:
ichthyosis: and sparse hair with
trichoschisis. All of the followin& are
true re&ardin& this patientGs condition
+OC+P/:
an autoso*al recessi3e *anner
$. 1f photosensiti3ity is a feature:
&onad si;e *ay #e nor*al
%. Patients *ay ha3e associated
cataracts
'. /he syndro*e is caused #y
i*paired nucleotide e<cision repair
(. Perifo3eal &listenin& white
dots are a feature
).
%( ,hich of the followin& is E9/
associated with Cronkhite"Canada
syndro*e.
1. 8enti&ines
$. Adeno*atous &astrointestinal
polyps
%. 2i#rocystic #reast disease
'. 9nycholysis
(. ,ei&ht loss
).
C
%) ,hich of the followin& cutaneous
6ndin&s are characteristic for
?ohwinkles Syndro*e.
1. Foneyco*#ed diMuse
pal*oplantar keratoder*a:
pseudoainhu* with
autoa*putation: star"shaped
keratosis o3er knuckles: nail
dystrophy: and alopecia
$. 0ense depi&*ented lusterless
hair: pili torti: dou&hy skin: diMuse
cutaneous hypopi&*entation
%. /ransient erythroder*a at
#irth: pal*oplantar keratoder*a:
follicular hyperkeratosis: scarrin&
alopecia: dystrophic nails
'. Hapidly pro&ressi3e alopecia
of all hair"#earin& areas:
onycholysis: onychoschi;ia:
onycho*adesis: hyperpi&*ented
*acules on e<tre*ities
(. 9ral papillo*atosis:
pal*oplantar keratoses: acral
keratoses: lipo*as: he*an&io*as:
scrotal ton&ue
).
A
%A A $ year old child is e3aluated for
suspected dia&nosis of
neuro6#ro*atosis. ,hich of the
followin& dia&nostic 6ndin&s is
typically a#sent on e<a* in this a&e
&roup.
1. neuro6#ro*as
$. *acrocephaly
%. pi&*ented iris ha*arto*as
'. sei;ures
(. cafe au lait *acules
).
A
%C Fyperkeratotic follicular nasal
papules ha3e #een descri#ed as a
paraneoplastic si&n in the settin& of
which neoplas*.
1. Multiple *yelo*a
$. Castle*anGs tu*or
%. AM8
'. Adenocarcino*a of the lun&
(. Henal cell carcino*a
).
A
%D /his syndro*e is cause #y defects in
the &enes that code for tu*or
suppressor proteins ha*artin and
tu#erin.
1. Bannayan"Hiley"Hu#alca#a
Syndro*e
$. Blue Hu##er Ble# Ee3us
Syndro*e
%. Cronkhite"Canada Syndro*e
'. Bourne3illeGs 0isease
(. CowdenGs Syndro*e
).
0
1'A
'! ,hich of the followin& is an
autoso*al recessi3e disorder
characteri;ed #y pili torti and
deafness.
1. ,aarden#ur& Syndro*e
$. S4or&en"8arsson Syndro*e
%. Hefsu* 0isease
'. B4ornstadGs Syndro*e
(. Cockayne Syndro*e
).
0
'1 ,hich type of porphyria is the
autoso*al recessi3e for* of
porphyria cutanea tarda.
1. +rythropoietic protoporphyria
=+PP>
$. Con&enital erythropoietic
porphyria =C+P>
%. Fepatoerythropoietic
porphyria =F+P>
'. ?arie&ate Porphyria =?P>
(. Acute 1nter*itent Porphyria
=A1P>
).
C
'$ All of the followin& are true re&ardin&
Cockayne Syndro*e +OC+P/:
1. 1nheritance is autoso*al
recessi3e
$. 1t is caused #y an ina#ility to
repair cyclo#utane di*ers
%. 1t is associated with #asal
&an&lia calci6cations
'. 1t is associated with retinal
pi&*ent de&eneration with a Isalt
and pepperI appearance
(. Eone of these answers are
incorrect
).
+
'% ,hich of the followin& is *ore
co**only associated with ulcerati3e
colitis as co*pared to CrohnJs
disease.
1. Pyoder*a &an&renosu*
$. 9ral lesions
%. Polyarteritis nodosa
'. 2istulae
(. Metastatic lesions
).
A
'' A ) *onth"old has a 3errucous
plaLue on the *ucosal surface of the
lower lip. Skin #iopsy is consistent
with Hi&a"2ede disease. Sou should
refer the patient to:
1. An ophthal*olo&ist
$. A &astroenterolo&ist
%. A neurolo&ist
'. A he*atolo&ist
(. An otolarn&olo&ist
).
C
'( Carotene*ia can #e a *anifestation
of:
1. Porphyria
$. Fypothyroidis*
%. Preti#ial *y<ede*a
'. 5ra3es disease
(. A*yloidosis
).
B
') Patients with ple<ifor* neuro*a and
E2 1 who also ha3e 7O5 are at
increased risk for de3elopin&:
1. 7u3enile chronic *yelo&enous
leuke*ia
$. Eon"Fod&kinGs 8y*pho*a
%. +sopha&eal cancer
'. Breast cancer
(. Medullary carcino*a of the
thyroid &land
).
A
'A /he *ost co**on autoi**une
disease associated with hepatitis C
is:
1. Autoi**une thyroiditis
$. Myasthenia &ra3is
%. Aplastic ane*ia
'. 8y*phocytic sialadenitis
(. Hheu*atoid arthritis
).
A
1'C
'C Patients with ,ernerJs syndro*e
typically e<perience which of the
followin& types of cardiac disease.
1. Fypertrophic cardio*yopathy
$. Aortic aneurys*s
%. Pre*ature atherosclerosis
'. Cardio*e&aly
(. Mitral 3al3e prolapse
).
C
'D He&ardin& paraneoplastic
pe*phi&us: which of the followin& is
/HB+.
1. 0es*oplakin: one of the
*olecular anti&ens: has a
*olecular wei&ht of 1D!kd
$. Metastatic sLua*ous cell
carcino*a of the skin is a co**on
cause
%. 5ranular C% deposition is
found at the der*oepider*al
4unction on direct
i**uno-uorescence
'. Monkey esopha&us is the
preferred su#strate for indirect
i**uno-uorescence
(. Eon"Fod&kins ly*pho*a is
rarely associated
).
C
(! He&ardin& erupti3e <antho*ata:
which of the followin& is /HB+.
1. /hey are associated with type
11 and 111 hyperlipide*ias
$. /hey are associated with
calciu* channel #lockers
%. /here is no association with
ethanol consu*ption
'. /hey are associated with type
1: 1?: and ? hyperlipide*ias
(. /hey fa3or the -e<or surfaces
of the e<tre*ities
).
0
(1 All of the followin& are seen *ore
co**only in CrohnGs disease than in
ulcerati3e colitis +OC+P/:
1. 9ral co##lestonin&
$. Polyarteritis nodosa
%. Pyosto*atitis 3e&etans
'. Perineal 6stulas
(. Perineal 6ssures
).
C
($ 1n patients with *i<ed
cryo&lo#uline*a associated with
hepatitis C: the *ost likely la#oratory
a#nor*ality is:
1. +le3ated rheu*atoid factor
$. P AEA
%. P p"AECA
'. 0ecreased cryo&lo#ulins
(. +le3ated he*atocrit
).
A
(% ,hat is the *ost co**on
*ali&nancy associated with this
condition at this location.
1. Breast cancer
$. 5astric cancer
%. /hyroid cancer
'. Pancreatic cancer
(. Melano*a
).
B
(' All of the followin& are true re&ardin&
the condition pictured +OC+P/:
1. Men with this condition *ay
#e at increased risk for ly*pho*a
$. Associated calcinosis cutis
*ay #e seen in pediatric patients
%. A&e"appropriate cancer
screenin& is reco**ended
'. May #e associated with a
psoriasifor* scalp der*atitis
(. +le3ated aldolase is *ore
+
1'D
speci6c than CPK
).
(( A )'"year old *an de3elops yellowish
perior#ital plaLues that occasionally
ulcerate and heal with scarrin&. ,hat
is the *ost likely associated la#
6ndin&.
1. Monoclonal &a**opathy
$. Positi3e antinuclear anti#odies
%. +le3ated creatinine
'. +le3ated tri&lycerides
(. 1ncreased thyroid sti*ulatin&
hor*one
).
A
() ,hich of the followin& is true
re&ardin& treat*ent of in-a**atory
der*atoses with potassiu* iodide.
1. /he ,olM"ChaikoM eMect *ust
#e considered
$. Bindin& of e<cess or&anic
iodide in the thryoid &land *ay
occur
%. /hyroid hor*one synthesis
*ay #e inhi#ited
'. Eone of the answers are
correct
(. All of these answers are
correct
).
+
(A ,hich of the followin& is
characteristic of dia#etic skin.
1. Appro<i*ately $!N of
dia#etics ha3e necro#iosis lipoidica
dia#eticoru* =E80>
$. /he le3el of clea3a&e in
#ullous dia#eticoru* is su#corneal
%. Candida tropicalis is the *ost
co**on cause of an&ular cheilitis
'. /here is a well"esta#lished
association #etween deep
&ranulo*a annulare =5A> and
dia#etes
(. Sellow skin *ay occur in up to
1!N of dia#etics
).
+
(C ,hich of the followin& diseases is
caused #y an en;y*atic defect that
occurs in the *itochondria.
1. Porphyria Cutanea /arda
$. Acute 1nter*ittent Porphyria
%. Con&enital +rythropoeitic
Porphyria
'. +rythropoeitic Protoporphyria
(. Fepatoerythropoetic Porphyria
).
0
(D SLua*ous cell carcino*a is seen in
which syndro*e.
1. 5orlin syndro*e
$. Ho*#o syndro*e
%. Eicolau"Balus syndro*e
'. Has*ussen syndro*e
(. Ba;e< syndro*e
=Acrokeratosis paraneoplastica>
).
+
)! /ripe pal*s are a cutaneous
*anifestation associated with which
of the followin& *ali&nancies.
1. Henal carcino*a
$. 8un& carcino*a
%. Prostate carcino*a
'. Colon carcino*a
(. Pancreatic carcino*a
).
B
)1 2eatures of Cushin& disease include
all of the followin& +OC+P/.
1. 2acial plethora
$. Striae
%. Fypertension
'. Suppression of corticotropin
occurs with ad*inistration of
0
1(!
de<a*ethasone
(. Firsutis*
).
)$ A A!"year old *ale de3elops
hyperpi&*ented 3el3ety plaLues on
his lips: dorsal hands and feet: and in
his a<illa. ,hat underlyin&
*ali&nancy is *ost co**only
associated with this 6ndin&.
1. 5astric Carcino*a
$. 8un& Carcino*a
%. 93arian Carcino*a
'. 8y*pho*a
(. Breast Carcino*a
).
A
)% ,hich of the followin& is a
paraneoplastic disease *ost often
associated with lun& carcino*a.
1. Fypertrichosis lanu&inosa
acLuisita
$. 0er*ato*yositis
%. Acanthosis ni&ricans
'. Paraneoplastic pe*phi&us
(. +rythroder*a
).
A
)' A )%"year"old *ale de3elops s*all:
non"tender: 3iolaceous papules on
his dorsal hands: face: ears: and
trunk. /he patient also de3elops a
destructi3e arthropathy with 6n&er
defor*ities. ,hat percenta&e of
patients with this condition has an
associated *ali&nancy.
1. $!"$(N
$. ("1!N
%. )("A!N
'. (!"((N
(. C("D!N
).
A
)( Fepatitis C infection is associated
with:
1. 5ianotti"Crosti syndro*e
$. Mi<ed cryo&lo#uline*ia
%. Pityriasis rosea
'. KapsiJs sarco*a
(. 9ral hairy leukoplakia
).
B
)) A patient presents with diMuse wa<y
keratoder*a of the pal*s and soles
as well as oral hairy leukoplakia.
,hich of the followin& state*ents
re&ardin& this condition is E9/ true.
1. /his condition *ay #e
associated with esopha&eal
carcino*a
$. /his condition is autoso*al
recessi3e
%. 2a*ily *e*#ers should #e
ad3ised to under&o cancer
screenin&
'. 2eatures *ay include
sLua*ous cell carcino*as arisin&
fro* keratoder*ic skin
(. Eone of these answers are
correct =all are true>
).
B
)A ,hich of the followin& *ay #e
associated with 5ra3esJ disease.
1. 0er*atitis herpetifor*is
$. 5eo&raphic ton&ue
%. Fypohidrosis
'. Madarosis
(. /hick: pale lips
).
A
)C /his autoso*al do*inant condition is
characteri;ed #y trichodisco*as:
6#roepithelial polyps: and
6#rofolliculo*as:
1. P9+MS syndro*e
$. Ho*#o syndro*e
%. Birt"Fo&&"0u#e syndro*e
'. Proteus syndro*e
(. CowdenGs disease
).
C
)D ,hich of the followin& skin 6ndin&s is
*ost closely linked to hepatocellular
carcino*a as a paraneoplastic
syndro*e.
1. Pityriasis lichenoides
$. Pityriasis al#a
%. Pityriasis a*iantacea
'. Pityriasis rotunda
0
1(1
(. Pityriasis rosea
).
A! A patient with &luten"sensiti3e
enteropathy presents with 3esicles
on the e<tensor surfaces of the
e<tre*ities. ,hat 6ndin&s are *ost
likely on a perilesional #iopsy.
1. 5ranular 1&A at the
der*oepider*al 4unction on direct
i**uno-uorescence
$. 8inear C% and 1&5 at the
der*oepider*al 4unction on direct
i**uno-uorescence
%. 8inear 1&A surroundin& 3essels
on direct i**uno-uorescence
'. PautrierJs *icro"a#scesses in
the epider*is on F @ +
(. 8eukocytoclastic 3asculitis
).
A
A1 An end sta&e A10S patient with
tu#erculosis presents with diMuse
hyperpi&*entation of #oth sun"
e<posed and une<posed areas. /he
pal*er creases are *arkedly
hyperpi&*ented and the patient is
3ery ill. /he *ost likely dia&nosis is:
1. Ar&yria
$. 8y*pho*a
%. /inea 3ersicolor
'. KaposiGs sarco*a
(. Addison disease
).
+
A$ /erryGs nails can *ost likely #e seen
in which of the followin& conditions.
1. Cirrhosis
$. CrohnGs disease
%. +nd"sta&e renal disease
'. Fidradenitis suppurati3a
(. Fyperthyroidis*
).
A
A% /he peak sensiti3ity to prophyrins
occurs at which wa3elen&ths.
1. $$!"$D!n*
$. $D!"%$!n*
%. %$!"'!!n*
'. '!!"'1!n*
(. '1!"'(!n*
).
0
A' Patients with this syndro*e are at
increased risk for de3elopin&
8her*ite"0uclos disease:
1. Bourne3illeGs 0isease
$. Eail"Patella Syndro*e
%. M+E /ype 11A
'. 2a#ryGs 0isease
(. CowdenGs Syndro*e
).
+
A( ,hich of the followin& state*ents
re&ardin& *ultiple endocrine
neoplasia syndro*es is true.
1. M+E /ype 11B is also known as
SippleGs Syndro*e
$. M+E /ype 11A is also known as
,er*erGs Syndro*e
%. Multiple *ucosal neuro*as
are seen in association with M+E
/ype 11A
'. 8ichen or *acular a*yloidosis
is seen in association with M+E
/ype 11A
(. Patients with M+E /ype 11B are
at increased risk for de3elopin&
follicular thyroid carcino*a
).
0
A) ,hich of the followin& is E9/ true
re&ardin& Cushin&Gs Syndro*e.
1. Brine cortisol le3els are
ele3ated
$. Corticotropin is suppressed
with the ad*inistration of
de<a*ethasone
%. 1t *ay #e associated with an
underlyin& oat cell lun& carcino*a
B
1($
'. 1t *ay #e associated with
hypertension and hypokale*ia
(. May present with
hyperpi&*entation and facial
plethora
).
AA ,hich of the followin& is not a
feature of Cronkhite"Canada
syndro*e.
1. 0iarrhea
$. Alopecia
%. 8un& carcino*a
'. 0ystrophic nails
(. Fyperpi&*ented *acules
).
C
AC ,hich of the followin& is E9/ true
re&ardin& calciphyla<is.
1. Patients with pro<i*ally"
located lesions ha3e a #etter
pro&nosis than those with acral
lesions
$. May #e treated with
parathyroidecto*y
%. May #e present with retifor*
purpura
'. Fistolo&ic 6ndin&s include
*edial calci6cation and inti*al
hyperplasia of s*all arteries and
arterioles
(. Fas an associated *ortality of
)!"C!N
).
A
AD ,ith re&ards to patients with
dia#etes *ellitus and skin: which of
the followin& is *ost accurate.
1. 0ia#etic der*opathy is *ost
co**only e<pressed on the
forear*s and feet
$. Sclerede*a *ost often
presents on the ti#ial surfaces
%. Sclerede*a is the *ost
co**on skin *anifestation of
dia#etes *ellitus
'. 8ess than (N of patients with
dia#etes *ellitus ha3e necro#iosis
lipoidica
(. 8ess than (N of patients with
necro#iosis lipoidica ha3e dia#etes
*ellitus
).
0
C! ,hich of the followin& is 2A8S+
re&ardin& 2a#ryJs disease.
1. 1t is inherited in an O"linked
recessi3e fashion
$. 1t is associated with acral
parasthesias
%. 1t is inherited in an O"linked
do*inant fashion
'. 1t *ay #e associated with
renal failure
(. /he etiolo&y is a defect in
alpha"&alactosidase A
).
C
C1 ,hich one of the followin& clinical
6ndin&s su&&ests the dia&nosis of
*ultiple *yelo*a.
1. Sudden eruption of se#orrheic
keratoses
$. Fyperkeratotic follicular
papules on the nose
%. +rythe*a: 3esicles: and
erosions in periori6cal and acral
areas
B
1(%
'. Concentric erythe*atous rin&s
with trailin& scale on trunk and
e<tre*ities
(. /ripe pal*s
).
C$ A co*plication seen in wo*en of
child#earin& a&e with the condition in
the 6&ure is:
1. Atrial septal defect
$. Pul*onary
ly*phan&ioleio*yo*a
%. 5astrointestinal #leedin&
'. 8isch nodules
(. Pul*onary e*#oli
).
B
C% ,hich of the followin& is =are>
characteristic of #asal cell ne3us
syndro*e.
1. Autoso*al recessi3e
inheritance
$. E+M9 &ene *utation
%. /ra*"track calci6cations
'. Colo#o*as
(. /elan&iectasias
).
0
C' ,hat is the uniLue la#oratory 6ndin&
in stool in porphyria cutanea tarda
=PC/> and hepatoerythropoietic
porphyria =F+P>.
1. ele3ated coproporphyrins
$. ele3ated isocoproporphyrins
%. decreased isocoproporphyrins
'. ele3ated protoporphyrins
(. ele3ated uroporphyrins
).
B
C( A A!"year old fe*ale de3elops
erythe*a with 6ne adherent scale on
acral skin that pro&resses to
keratoder*a and e3entually a *ore
&enerali;ed psoriasifor* der*atitis.
,hat is the *ost likely underlyin&
*ali&nancy.
1. SLua*ous cell carcino*a of
the laryn<
$. Adenocarcino*a of the colon
%. Adenocarcino*a of the #reast
'. SLua*ous cell carcino*a of
the 3a&ina
(. Medullary thyroid carcino*a
).
A
C) ,hich of the followin& is /HB+ a#out
dia#etic"related skin disease.
1. Bullae are co**on on the
thi&hs
$. Sellow skin aMects the *a4ority
of dia#etic patients
%. 0ia#etic der*opathy aMects
the upper #ack
'. Eecro#iosis lipoidica aMects
appro<i*ately $!N of dia#etics
(. 0irect i**uno-uorenscence is
usually ne&ati3e in #ullous
dia#eticoru*
).
+
CA /he shoulder pad si&n has #een
descri#ed in which disease.
1. 0er*ato*yositis
$. Cushin&s disease
%. Syste*ic a*yloidosis
'. Eephro&enic 6#osin&
der*opathy
(. Syste*ic lupus erythe*atosis
).
C
CC He&ardin& erupti3e <antho*as:
which of the followin& is true.
1. /hey occur in the settin& of
fa*ilial hyperlipide*ia types 1: 1?:
and ?
$. /hey occur in the settin& of
fa*ilial hyperlipide*ia types 11 and
111
%. /ri&lyceride le3els are usually
#elow (!!*&dl
A
1('
'. /hey are *ost co**only
found on the eyelids
(. /hey are not related to alcohol
consu*ption
).
CD /he presence of anti#odies to c"AECA
is characteristically seen in patients
with which disease.
1. Bl3erati3e colitis
$. Chur&"Strauss disease
%. Polyarteritis nodosa
'. ,e&enerJs &ranulornatosis
(. Eodular 3asculitis
).
0
D! All of the followin& are true re&ardin&
incontinentia pi&*enti +OC+P/:
1. 1t is caused #y a *utation in
the E+M9 &ene
$. 1t is an O"linked recessi3e
disorder
%. 1n-a**ation and #listerin&
*ay #e followed #y hyperkeratotic:
3errucous lesions
'. 1t is associated with cere#ellar
ata<ia
(. 1t is associated with colo#o*a
and retinal detach*ent
).
B
D1 Paraneoplastic pe*phi&us is
associated with all of the followin&
underlyin& *ali&nancies +OC+P/:
1. Eon"Fod&kins ly*pho*a
$. 8un& carcino*a
%. Chronic ly*phocytic leuke*ia
'. /hy*o*a
(. Castle*anGs tu*or
).
B
D$ A patient infected with the hepatitis
C 3irus is at hi&hest risk for which of
the followin& cutaneous
*anifestations.
1. 1ncreased hyaluronic acid in
der*is of lower and upper
e<tre*ities
$. 8indsayJs nails
%. Con&enital hyperpi&*entation
of the retinal pi&*ent =CFHP+>
'. Periori6cial lenti&ines
(. Positi3e rheu*atoid factor and
decreased co*ple*ent =C%>
).
+
D% A patient on he*odialysis presents
with indurated plaLues ha3in& a peau
dJoran&e te<ture on the #ilateral
lower le&s. ,hich of the followin&
state*ents is /HB+.
1. /he dia&nostic
histopatholo&ical 6ndin&s include
acanthosis and hyperkeratosis
$. Seru* protein electrophoresis
should #e perfor*ed
%. 0apsone will likely #e eMecti3e
treat*ent
'. /he face is usually is aMected
(. /he pal*s and soles are
usually aMected
).
B
D' /he *ost co**on location of the
lesions in nephro&enic 6#rosin&
der*opathy is:
1. 2ace
$. Pal*s and soles
%. 8ower e<tre*ities
'. Back
(. Chest
).
C
D( A (( year old patient presents with
new onset #rown *acules on ar*s:
le&s: face and pal*s. She &i3es a %
*onth history of diarrhea: a#do*inal
1. Peut;"7e&hers syndro*e
$. Cowden disease
%. Blcerati3e colitis
'. Cronkhite"Canada syndro*e
0
1((
cra*ps: wei&ht loss and protein"
losin& enteropathy. /he *ost likely
dia&nosis is:
(. Plu**er"?inson syndro*e
).
D) All of the followin& are true re&ardin&
calciphyla<is e<cept:
1. Seen in end"sta&e renal
disease
$. ?ascular *ural calci6cation
occurs late in the process
%. Fi&h *orality rate is due to
sepsis
'. Association with
hyperparathyroidis*
(. Association with an ele3ated
calciu*: phosphate product
).
B
DA All of the followin& state*ents
re&ardin& cryo&lo#uline*ia are true
+OC+P/:
1. /ype 1 is co*posed of
*onoclonal 1&5 and polyclonal 1&M
$. /ype 11 is co*posed of
polyclonal 1&5 and *onoclonal 1&M
%. /ype 111 is co*posed of
polyclonal 1&5 and polyclonal 1&M
'. C!N of cases of *i<ed
cryo&lo#uline*ia are associated
with Fepatitis C infection
(. Eone of these answers are
correct =all state*ents are true>
).
A
DC ,hich of the followin& porphyria
cutanea tarda associations has a
direct relationship to the le3el of
urine uroporphyrins.
1. 0ystrophic calci6cations
$. +stro&en le3els
%. Scleroder*oid chan&es
'. HBC -uorescence
(. Fypertrichosis
).
C
DD ,hich of the followin& is E9/
associated with Fepatitis C disease.
1. Mi<ed cryo&lo#uline*ia
$. Broporphyrino&en
decar#o<ylase de6ciency
%. Sin&le"stranded HEA 3iridae
'. 8eukocytoclastic 3asculitis
(. Sin&le"stranded 0EA 3iridae
).
+
1!
!
,hat is the treat*ent of choice for
porphyria cutanea tarda.
1. Phle#oto*y
$. Anti*alarials
%. +rythropoietin
'. 9ral iron supple*entation
(. Eapro<en
).
A
1!
1
A patient with con&enital
hypertrophy of retinal epitheliu* is
*ost likely to ha3e:
1. An autoso*al do*inant
*utation in the MSF$ &ene
$. Pheochro*ocyto*a
%. Adeno*atous polyposis
'. /ra*"track calci6cations on
head radio&raph
(. Pe&"shaped teeth
).
C
1!
$
/he e<pected histolo&y of a #iopsy
take fro* the lesion shown in the
i*a&e would
1. 1ncreased *ucin
$. Schu*ann #odies
%. 5ranulo*atous in6ltrate
locali;ed to the papillary der*is
'. +lastic 6#er de&eneration
(. Colla&en de&eneration
).
+
1()
1!
%
+rythe*a &yratu* repens is known
to #e associated with all of the
followin& *ali&nancies e<cept:
1. 8un& carcino*a
$. Breast carcino*a
%. Cer3ical carcino*a
'. Bladder carcino*a
(. 5astric carcino*a
).
+
1!
'
,hich of the followin& is true
re&ardin& nephro&enic 6#rosin&
der*opathy.
1. Fas a rapidly pro&ressi3e #ut
re3ersi#le course
$. 1s associated with a
paraproteine*ia
%. 1s associated with peripheral
eosinophilia
'. May #e associated with
antiphospholipid anti#odies
(. 1s associated with a dra*atic
increase in der*al *ucin
).
0
1!
(
,hich of the followin& state*ents
re&ardin& porphyrias is 2A8S+.
1. 2ecal coproporphyrino&en is
increased in 3arie&ate porphyria
$. Fepatoerythropoietic
porphyria is the ho*o;y&ous for*
of porphyria cutanea tarda
%. Acute inter*ittent porphyria
has no skin 6ndin&s
'. Coproporphyrino&en is
ele3ated *ore than
uroporphyrino&en in $' hour urine
sa*ples in porphyria cutanea
tarda
(. 1n erythropoietic
protoporphyria: protoporphyrin 1O
a#sor#s in the Soret #and
).
0
1!
)
/he clinical 6ndin&s in 6&ure % are
associated with which disorder.
1. 5ra3es disease
$. Myasthenia &ra3is
%. 0er*ato*yositis
'. Sarcoidosis
(. Hheu*atoid Arthritis
).
A
1!
A
,hich step is rate"li*itin& in the
synthesis of protoporphyrino&en.
1. A*inole3ulinic acid synthase
$. A*inole3ulinic acid
dehydratase
%. Porpho#illino&en dea*inase
'. Coproporphyrino&en o<idase
(. 2errochelatase
).
A
1(A
11 . 0isorders of the Fair and Eails
# Question Answers Corre
ct
Answ
er
1 Koilonychia is *ost co**only seen in
association with:
1. Henal disease
$. Pro&ressi3e syste*ic sclerosis
%. Alopecia areata
'. 1*paired iron *eta#olis*
(. Pul*onary disease
). Show +<plaination
0
$ /he syndro*e includin& *ental and physical
retardation: con3ulsions: episodic
unconsciousness: li3er enlar&e*ent: skin
lesions: and dry and #rittle hair showin&
trichorrhe<is nodosa *icroscopically and
-uorescin& red. is:
1. Ba;e< 2ollicular Atrophoder*a
$. CrandallGs syndro*e
%. Citrulline*ia
'. Ar&ininosuccinic aciduria
(. B4ornstadGs syndro*e
). Show +<plaination
0
% B4Jrnstad syndro*e is the co*#ination of pili
torti and which of the followin& features.
1. 8enti&ines
$. ,hite forelock
%. Fypo&onadis*
'. 0eafness
(. Sei;ures
). Show +<plaination
0
' A ' year"old #oy has a sin&le circular alopecic
atrophic patch on the 3erte< of the scalp. /his
*ost likely is due to which of the followin&
conditions.
1. Aplasia cutis con&enita
$. Con&enital syphilis
%. Keratosis 2ollicularis Spinulosa
0ecal3ans
'. Morphea en coup de sa#re
(. /rian&ular Alopecia
). Show +<plaination
A
( Fi&hest &raft sur3i3al in hair transplantation is
achie3ed throu&h the use of:
1. '"( ** plu&s
$. Mini&rafts
%. Sin&le hairs
'. 2ollicular units
(. Micro&rafts
). Show +<plaination
0
) Ar&ininosuccinic aciduria is characteristically
associated with this hair 6ndin& Jna*e the
condition pictured #elow:
1. Pili trian&uli et canaliculi
$. /richoschisis
%. Monilethri<
'. /richorrhe<is nodosa
(. /richorrhe<is in3a&inata
). Show +<plaination
0
A Acute paronychia is *ost co**only caused #y
which of the followin& or&anis*s.
1. Candida al#icans
$. Candida tropicalis
%. Pseudo*onas aeru&inosa
'. Staphylococcus aureus
(. /richophyton ru#ru*
). Show +<plaination
0
C A patient with diMuse se3ere sudden hair loss
de3elopin& % *onths after hospitali;ation for
septice*ia likely has which of the followin&
conditions.
1. Ana&en eRu3iu*
$. Cata&en eRu3iu*
%. /elo&en eRu3iu*
'. 8oose ana&en syndro*e
(. Bnco*#a#le hair syndro*e
). Show +<plaination
C
D ,hich &enoder*atosis characteri;ed #y #road
thu*#s and this nail disorder pictured #elow.
1. Hoth*und"/ho*pson
$. /u#erous sclerosis
%. Pachyonychia con&enita
'. Proteus syndro*e
(. Hu#enstein"/ay#i syndro*e
). Show +<plaination
+
1! /he #est dia&nosis for this scarrin& for* of
alopecia is
1. Chronic cutaneous lupus
erythre*atosus
$. 8ichen planopilaris
0
1(C
%. Peseudopelade of BroL
'. Perifolliculitis capitis a#scedens et
suModiens
(. Central centrifu&al cicatricial
alopecia
). Show +<plaination
11 +ndony< onycho*ycosis is due to: 1. /richophyton ru#ru*
$. /richophyton *enta&rophytes
%. /richophyton soudanense
'. Scytalidiu* di*idiatu*
(. Scopuliaropsis
). Show +<plaination
C
1$ A patient with diMuse hair loss de3elopin& after
a thalliu* scan likely has which of the
followin& conditions.
1. Ana&en eRu3iu*
$. Cata&en eRu3iu*
%. /elo&en eRu3iu*
'. 8oose ana&en syndro*e
(. Bnco*#a#le hair syndro*e
). Show +<plaination
A
1% Air spaces in the hair shaft lead to this
condition pictured #elow J na*e the
condition:
1. Pili trian&uli et canaliculi
$. Pili annulati
%. /richoschisis
'. Pohl Pinkus constriction
(. ,ooly hair
). Show +<plaination
B
1' /he defect associated with the hair 6ndin&
shown in the i*a&e is:
1. hFB)hFB1
$. hFBAhFB$
%. hFBChFB%
'. hFBDhFB'
(. hFB1!hFB(
). Show +<plaination
A
1( /erryGs nails are seen in which of the followin&
conditions.
1. Henal failure
$. Pul*onary 6#rosis
%. 0ia#etes
'. Bladder carcino*a
(. Aerodi&esti3e carcino*a
). Show +<plaination
C
1) A patient with curly hair that strai&htened
after pu#erty: ena*el hypoplasia: dental pits:
and increased #one density likely has a
*utation in which of the followin& &enes.
1. 0istal"less ho*eo#o<"% &ene =08O%>
$. ?ascular"endothelial &rowth factor
receptor %
%. Bone *orpho&enetic protein type $
'. S8BHP 1
(. SP1EK (
). Show +<plaination
A
1A Pro<i*al white su#un&ual onycho*ycosis with
polydactylous in3ol3e*ent needs at least one
la#oratory test:
1. Blood count
$. Sedi*entation rate
%. /"helper C0' ly*phocytes
'. 8i3er en;y*es
(. F1?
). Show +<plaination
+
1C A patient has hyperkeratotic tissue on the
lateral and pro<i*al nails folds. ,hat is the
dia&nosis.
1. 9nychophosis
$. 9nycho*adesis
%. Fapalonychia
'. 9nychocryptosis
(. 9nychopha&ia
). Show +<plaination
A
1D Black nail is caused #y: 1. /richophyton *enta&rophytes
$. Proteus *ira#ilis
%. Pseudo*onas spp.
'. Staphylococcus aureus
(. Fortaea werneckii
). Show +<plaination
B
$! A child presents with sparse: 6ne hair: thin
nails and loose skin in infancy. Fe has a pear"
shaped: #road nose and on O"ray has cone"
shaped epiphyses. ,hich of the followin&
1. P)%
$. 08O%
%. HMHP
'. /HPS1
0
1(D
&enes is *utated in this syndro*e. (. ABCC)
). Show +<plaination
$1 ,hich of the followin& syndro*es does E9/
ha3e the 6ndin& shown in the i*a&e as part of
the spectru*.
1. Crandall
$. Ar&ininosuccinic aciduria
%. Citrulline*ia
'. MenkeGs Kinky Fair
(. Eetherton
). Show +<plaination
A
$$ ,hich part of the nail co*ple< results in nail
pits.
1. Pro<i*al nail fold
$. Pro<i*al nail *atri<
%. 0orsal nail *atri<
'. Eail plate
(. Eail #ed
). Show +<plaination
B
$% ,hat is the &ene defect that causes red hair. 1. /yrosinase
$. P protein
%. Melanocortin 1 receptor
'. /yrosine a*inotransferase
(. /yrosinase"related protein 1
). Show +<plaination
C
$' Si&ns of 3irili;ation include all of the followin&
+OC+P/:
1. Centripetal o#esity
$. /e*poral #aldin&
%. Clitoro*e&aly
'. 1ncreased *uscle *ass in the li*#
&irdles
(. Acne
). Show +<plaination
A
$( /rian&ular lunulae are: 1. Part of the syndro*e caused #y a
8MO1# *utation
$. Associated with hyperplastic patellae
%. Associated with a renal cell
carcino*a
'. Associated with a *utation of
A/P$C1
(. Associated with a *utation of
S+HCA$
). Show +<plaination
A
$) A patient with wooly hair: diMuse pal*oplantar
keratoder*a: and ri&ht 3entricular
arrhyth*o&enic cardio*yopathy likely has a
*utation in which of the followin& &enes.
1. FFB)
$. Plako&lo#in
%. Plakophilin
'. SP1EK (
(. S8BHP 1
). Show +<plaination
B
$A A co**only known cause of splinter
he*orrha&es in the nail is endocarditis. ,hich
of the followin& would #e unlikely to cause
splinter he*orrha&es.
1. /richinosis
$. /rau*a
%. Psoriasis
'. ?asculitis
(. Hheu*atoid arthritis
). Show +<plaination
+
$C A si&ni6cantly increased nu*#er of Iclu#
hairsI on a pull test is indicati3e of:
1. Ana&en eRu3iu*
$. /elo&en eRu3iu*
%. Eor*al hair anato*y
'. Alopecia areata
(. An&ro&enetic alopecia
). Show +<plaination
B
$D ,hich of the followin& is an e<a*ple of an
apparent leukonychia.
1. /erryGs lines
$. MeeGs lines
%. MuehrckeGs lines
'. FutchinsonGs lines
(. 9nychoschi;ia
). Show +<plaination
C
%! A si< year old &irl presents after #ein& sent
ho*e fro* school for IliceI. 9n e<a*ination:
there are structures on the hair which are
freely slide alon& the hair shaft. ,hat is the
1. Pediculosis
$. Fair casts
%. /richoptilosis
'. Monilithri<
B
1)!
*ost likely dia&nosis. (. Pili annulati
). Show +<plaination
%1 /he #est test for Cushin& syndro*e is: 1. Plas*a 8F
$. Plas*a testosterone
%. Plas*a prolactin
'. Plas*a 0F+A
(. 93erni&ht de<a*ethasone
suppresion test
). Show +<plaination
+
%$ Sellow nails can #e seen in each of the
followin& syndro*es e<cept:
1. Bronchiectasis
$. Fyperlipide*ia
%. /o#acco use
'. /hyroid disease
(. Penicilla*ine
). Show +<plaination
B
%% A patient with synophrys: dystopia canthoru*:
and heterochro*ia iridu* irides likely has
which of the followin& hair a#nor*alities.
1. 0iMuse thinnin&
$. Scarrin& alopecia
%. /richorrhe<is in3a&inata
'. /richorrhe<is nodosa
(. ,hite forelock
). Show +<plaination
+
%' /his hair 6ndin& is caused #y *utations in
what &ene.
1. SP1EK (
$. E+M9
%. S+HCA$
'. 0yskerin
(. Keratin 1)
). Show +<plaination
A
%( A su#un&ual he*ato*a co3erin& (!N of the
nail#ed should #e *ana&ed #y which of the
followin&.
1. Eo treat*ent
$. He*o3al of the nail plate
%. /rephination of the nail plate
'. Eeedle aspiration of the he*ato*a
(. Pressure dressin&
). Show +<plaination
B
%) AcLuired pro&ressi3e kinkin& of hair is a
co*plication of which of the followin&
*edications.
1. Anti*eta#olites
$. Anti*alarials
%. Hetinoids
'. Slfona*ides
(. 0apsone
). Show +<plaination
C
%A ,hich of the followin& syndro*es does not
ha3e 0orsal ptery&iu* as a feature:
1. 8ichen planus
$. 8esch"Eyhan syndro*e
%. Cicatricial pe*phi&oid
'. Chronic 5?F0
(. 8a*ellar ichthyosis
). Show +<plaination
+
%C MuehrckeGs nails are *ost often associated
with:
1. Fyperthyroidis*
$. Fypothyroidis*
%. Fypoal#u*ine*ia
'. Fyperal#u*ine*ia
(. Eone of these answers are correct
). Show +<plaination
C
%D Choose the correct state*ent re&ardin& white
piedra.
1. Co**only occurs in the tropics
$. Consists of crea*"colored colonies
attached to hairs
%. /reat*ent consists of cuttin& the hair
'. 1s caused #y piedra hortae
(. Both Consists of crea*"colored
colonies attached to hairs and
/reat*ent consists of cuttin& the hair
). Show +<plaination
+
'! /he *ost co**on en;y*e a#nor*ality in
con&enital adrenal hyperplasia is:
1. %"#eta"hydro<ysteroid
dehydro&enase iso*erase
$. 11"#eta"hydro<ylase
%. $1"hydro<ylase
'. 1("hydro<ylase
C
1)1
(. 1A"hydro<ylase
). Show +<plaination
'1 Pri*ary total dystrophic onycho*ycosis is due
to:
1. Candida spp
$. 2usariu*
%. /richophyton ru#ru*
'. Scytalidiu* di*idiatu*
(. Scopulariopsis #re3icaulis
). Show +<plaination
A
'$ Spotted red lunulae are a#sent in which of the
followin& conditions.
1. Alopecia areata
$. Keratosis follicularis
%. Syste*ic lupus erythe*atosus
'. Hheu*atoid arthritis
(. 8ichen planus
). Show +<plaination
B
'% 2rontal #ossin&: saddle nose: hypoplastic
*idface: pe& shaped or conical teeth and
hypopi&*ented short sparse scalp and #ody
hair are pro*inent features of which of the
followin&
1. Christ Sie*ens /ouraine syndro*e
$. Fidrotic ectoder*al dysplasia
%. Ar&inosuccinic aciduria
'. Monilethri<
(. Pachyonychia con&enita
). Show +<plaination
A
'' /he Ira&&ed cuticleI seen in der*ato*yositis
is also known as:
1. Sa*it; si&n
$. ?entral ptery&iu*
%. Plu**ers si&n
'. Candy"cane nails
(. +*peripolesis
). Show +<plaination
A
'( /he co*#ination of poliosis: u3eitis: deafness:
and 3itili&o are characteristic of which of the
followin& conditions.
1. Pie#aldis*
$. ,aardern#ur& syndro*e
%. Cronkhite"Canada syndro*e
'. ?o&t"Koyana&i"Farada syndro*e
(. Cornelia de 8an&e Syndro*e
). Show +<plaination
0
') 0eposition of *ucin in the hair follicle can #e
associated with which disease.
1. Keratosis 2ollicularis Spinulosa
0ecal3ans
$. Ada*s"9li3er Syndro*e
%. Mycosis fun&oides
'. Acne Keloidalis Euchae
(. Perifolliculitis Capitis A#scedens et
SuModiens
). Show +<plaination
C
'A Con&enital &enerali;ed hypertrichosis is
associated with which of the followin&
sy*pto*s.
1. Andro&en"secretin& o3arian tu*ors
$. Pituitary insuTciency
%. 0istichiasis
'. Methi*a;ole terato&enicity
(. 5in&i3al 6#ro*atosis
). Show +<plaination
+
'C ,hich of the followin& is E9/ a cause of red
lunulae.
1. +ndocarditis
$. Psoriasis
%. Car#on *ono<ide poisonin&
'. 1*uran
(. Hheu*atoid arthritis
). Show +<plaination
A
'D Pili trian&uli et canaliculi is the characteristic
hair 6din& in which of the followin& disoders.
1. Monilethri<
$. Pili annulati
%. Ea<os syndro*e
'. Anhidrotic ectoder*al dysplasia
(. Bnco*#a#le hair syndro*e
). Show +<plaination
+
(! MeeGs lines are: 1. 0ou#le white trans3erse lines fro*
a#nor*al 3ascular #ed
$. Brownish *acules #eneath the nail
plate
%. 8ocal or diMuse hyperkeratotic tissue
that de3elops on the lateral or
pro<i*al nail folds
0
1)$
'. /rans3erse white lines that aMect all
nails: &row out with nail &rowth
(. ?ertical #lack lines on a sin&le or
*ultiple nails
). Show +<plaination
(1 0istal su#un&ual onycholysis associated with
paronychia is due to:
1. Candida spp
$. 2usariu* spp
%. Scytalidiu* di*idiatu*
'. /richophyton ru#ru*
(. /richophyton *enta&rophytes
). Show +<plaination
C
($ Psoriatic onycholysis is caused #y psoriasis in
which of the followin& nail su#units.
1. Eail *atri<
$. Eail plate
%. Eail #ed
'. Pro<i*al nail fold
(. Fyponychiu*
). Show +<plaination
C
(% ,hich of the followin& *edication is a cause of
hirsutis* without 3irili;ation.
1. 0apsone
$. 0ia;o<ide
%. 0ia;epa*
'. 0initrochloro#en;ene
(. 0antrolene
). Show +<plaination
B
(' /he 3isi#le portion of the nail *atri< is called
the:
1. +ponychiu*
$. 8unula
%. Cuticle
'. Fyponychiu*
(. Eail plate
). Show +<plaination
B
(( /he co*#ination of a low"set hairline and
synophrys is seen in which of the followin&
conditions.
1. ,erner syndro*e
$. /urner Syndro*e
%. Eoonan Syndro*e
'. Cornelia de 8an&e Syndro*e
(. ,aarden#ur&Gs syndro*e
). Show +<plaination
0
() /he distal nail *atri< is 3isi#le at the followin&
portion of the nail unit:
1. 9nychoder*al #and
$. Fyponychiu*
%. 8unula
'. Cuticle
(. 8ateral nailfold
). Show +<plaination
C
(A ,hich of the followin& are 6ndin&s associated
with Eail"Patella Syndro*e.
1. 5lo*erulonephritis
$. Alopecia
%. Bladder di3erticuli
'. Photosensiti3ity
(. Fip dysplasia
). Show +<plaination
A
(C ,hich autoanti#ody is associated with these
cuticular chan&es: shawl si&n: and o3erall
fa3ora#le pro&nosis.
1. Mi"$
$. 7o"1
%. Fi&h titered AEA with speckled
pattern
'. Scl"A!
(. Ho
). Show +<plaination
A
(D /richo#e;oar is is a potentially life"threatenin&
co*plication of:
1. Alopecia areata
$. Anhidrotic ectoder*al dysplasia
%. /richotillo*ania
'. 0iscoid lupus
(. 8ichen planopilaris
). Show +<plaination
C
)! Plu**erGs nails are associated with which of
the followin& disorders.
1. 0er*ato*yositis
$. Syste*ic sclerosis
%. 8upus erythe*atosus
'. Fyperthyroidis*
(. 8ead poisonin&
0
1)%
). Show +<plaination
)1 /ayJs syndro*e is characteri;ed #y this hair
condition pictured #elow J identify the
condition:
1. /richorrhe<is nodosa
$. /richorrhe<is in3a&inata
%. /richoschisis
'. Monilethri<
(. Pili trian&uli et canaliculi
). Show +<plaination
C
)$ He&ardin& andro&ens in wo*en: which of the
followin& state*ents is E9/ correct.
1. /estosterone #inds the andro&en
receptor
$. +ye#rows: eyelashes and 3ellus hairs
are andro&en"dependent
%. /he hair follicle reLuires con3ersion
of testosterone to
dihydrotestosterone for e<pression of
andro&en action
'. 0ihydrotestosterone #inds the
andro&en receptor
(. /here are no diMerences in
eyelashes: eye#rows and 3ellus hair"
#earin& areas in *en and wo*en
). Show +<plaination
B
)% A $' year"old wo*an presents with the
co*plaint of hirsutis* and asks a#out therapy.
She has a 3irili;ation pattern of hair &rowth.
9n Luestionin&: she relates ha3in& irre&ular
*enstrual periods and acne. ,hich of the
followin& is the *ost likely dia&nosis.
1. Pheochro*ocyto*a
$. Polycystic o3arian disease
%. Con&enital adrenal hyperplasia
'. 93arian carcino*a
(. Eor*al 3ariant
). Show +<plaination
B
)' 8indsayGs nails =distal nail nor*al: pro<i*al nail
white> is characteristic of:
1. Chronic renal failure
$. Plu**er"?inson syndro*e
%. Fe*ochro*atosis
'. +ctoder*al dysplasia
(. 8+9PAH0 syndro*e
). Show +<plaination
A
)( Sellow nail syndro*e has #een associated with
use of which of the followin& treat*ents for
Hheu*atoid Arthritis.
1. 0"penicilla*ine
$. Methotre<ate
%. 1n-i<i*a#
'. +tanercept
(. Adali*u*a#
). Show +<plaination
A
)) Mutations in c"kit are associated with which of
the followin& conditions.
1. ,aarden#ur& syndro*e
$. Pie#aldis*
%. /u#erous sclerosis
'. ?o&t"koyana&i"harada
(. Cornelia de 8an&e Syndro*e
). Show +<plaination
B
)A An 1C year"old &irl who was hospitali;ed last
*onth after a serious car accident is noted to
ha3e white trans3erse &roo3es on her
6n&ernails and toenails. /he *ost likely
dia&nosis is:
1. /wenty"nail dystrophy
$. BeauJs lines
%. Falf"and"half nails
'. MeesJ lines
(. /erryJs nails
). Show +<plaination
B
)C /rian&ular lunulae are seen in what disorder. 1. 0yskeratosis con&entia
$. Eeuro6#ro*atosis 11
%. 5orlinJs syndro*e
'. Eail"patella syndro*e
(. Papillon"8efe3re syndro*e
). Show +<plaination
0
)D ?entral ptery&iu* pictured #elow is
characteristically associated with what
disorder.
1. 8ichen planus
$. Syste*ic sclerosis
%. Cicatricial pe*phi&oid
'. S7S/+E
(. Chronic 5?F0
). Show +<plaination
B
A! /rans3erse white #ands on one or two nails is
caused #y:
1. /rau*a to the *atri<
$. Alopecia areata
%. Psoriasis
A
1)'
'. Syste*ic lupus erythe*atosis
(. 8ichen planus
). Show +<plaination
A1 ,hat condition *ost likely descri#es a hair
defect with ruRed cuticle in '"year old fe*ale
with #lond hair.
1. Pili torti
$. Pili annulati
%. ,ooly hair
'. 8oose ana&en hair syndro*e
(. Monilethri<
). Show +<plaination
0
A$ Mutations in hair keratins hFB) and hFB1
cause this characteristic 6ndin& pictured #elow
J na*e the condition:
1. /richoptilosis
$. Fair casts
%. /i&er"tail hair
'. /richoschisis
(. Monilethri<
). Show +<plaination
+
A% Blue lunulae are characteristic of which
disease.
1. Sellow nail syndro*e
$. ,ilsonGs disease
%. Hu#enstein"/ay#i syndro*e
'. Fypertrophic pul*onary
osteoarthropathy
(. Clu##in&
). Show +<plaination
B
A' /he *ost co**on cultured a&ent in chronic
paronychia associated with a #lack hue of the
lateral ed&e of the nail plate is:
1. /richophyton ru#ru*
$. &ra*"ne&ati3e #acteria
%. Candida spp
'. Scytalidiu* di*idiatu*
(. Scopulariopsis #re3icaulis
). Show +<plaination
C
A( /his nail 6ndin& is characteristically associated
with what disorder.
1. Con&enital heart failure
$. Chronic renal failure
%. Ane*ia
'. Fyperthyroidis*
(. Cirrhosis
). Show +<plaination
B
A) Papular atrichia is caused #y *utations in
which &ene.
1. ,in&less
$. Patched
%. Fairless
'. 2o< forehead
(. 0istal"less ho*e#o#o<
). Show +<plaination
C
AA Sellow nail syndro*e can #e associated with: 1. 0"penicilla*ine use in patients with
rheu*atoid arthritis
$. ,ilsonJs disease
%. Alopecia areata
'. 0o<oru#icin
(. Minocycline use in acne patients
). Show +<plaination
A
AC /he hair 6ndin& characteri;ed #y an
in3a&ination of the distal hair shaft into the
cup for*ed #y the pro<i*al hair shaft is:
1. /richoschisis
$. Pili torti
%. Pili trian&ulati
'. /richorrhe<is nodosa
(. /richorrhe<is in3a&inata
). Show +<plaination
+
AD /hin hair with pre*ature &rayin& is
characteristic of which of the followin&
syndro*es.
1. ,erner syndro*e
$. /urner Syndro*e
%. Eoonan Syndro*e
'. Cornelia de 8an&e Syndro*e
(. ,aarden#ur&Gs syndro*e
). Show +<plaination
A
C! ,hich of the followin& is the predo*inant
der*atoscopic 6ndin& seen in alopecia areata.
1. 0iMuse white knots and a #rush"
pattern
$. Perifollicular ar#ori;in& 3essels
%. Sellow dots
'. Heduction of follicular ostia
(. S*all o3al nodes
C
1)(
). Show +<plaination
C1 2rayin& of the cuticles is a si&n of which of the
followin& conditions.
1. 0er*ato*yositis
$. Syste*ic sclerosis
%. 8upus erythe*atosus
'. Fypothyroidis*
(. 8ead poisonin&
). Show +<plaination
A
C$ Chronic paronychia is *ost co**only caused
#y which of the followin& or&anis*s.
1. Candida al#icans
$. Candida tropicalis
%. Pseudo*onas aeru&inosa
'. Staphylococcus aureus
(. /richophyton ru#ru*
). Show +<plaination
A
C% A wo*an with hypopi&*ented in lines of
Blaschko and scarrin& alopecia likely suMers
which of the followin& conditions.
1. Chondrodysplasis punctata
$. Anhidrotic +ctoder*al 0ysplasia
%. 2ocal 0er*al Fypoplasia
'. Hoth*und"/ho*son Syndro*e
(. Bloch"Sul;#er&er Syndro*e
). Show +<plaination
+
C' Fow lon& should the last wash"out period
#efore perfor*in& *ycolo&ic in3esti&ations in
a clinically recurrent onycho*ycosis treated #y
ter#ina6ne: itracona;ole or -ucona;ole:
1. 9ne *onth
$. /wo *onths
%. /hree *onths
'. 2our *onths
(. Si< *onths
). Show +<plaination
C
C( Blue lunulae are associated with each of the
followin& e<cept:
1. Ar&yria
$. Cardiac failure
%. Quinacrine
'. ,ilsonJs disease
(. Phenolphthalein
). Show +<plaination
B
C) ,hich part of the *atri< &i3es rise to the
dorsal nail plate.
1. 0istal *atri<
$. Pro<i*al *atri<
%. ?entral *atri<
'. 0orsal *atri<
(. 8ateral *atri<
). Show +<plaination
B
CA A patient with sparse hair: a pear"shaped
#road nose and cone"shaped epiphyses likely
suMers which of the followin& conditions.
1. 2ocal 0er*al Fypoplasia =5olt;
syndro*e>
$. /richo"rhino"phalan&eal Syndro*e
%. Fay",ells Syndro*e
'. +ctrodactyly"+ctoder*al dysplasia"
Cleftin& =++C>
(. /richodentoosseous Syndro*e
). Show +<plaination
B
CC Atrophy of the isth*us is a characteristic
histolo&ic 6ndin& of which of the followin&
conditions.
1. 0iscoid lupus erythe*atosus
$. 8ichen planopilaris
%. Parry"Ho*#er& syndro*e
'. 2olliculitis 0ecal3ans
(. Acne Keloidalis Euchae
). Show +<plaination
B
CD A patient with cirrhosis has noticed that the
pro<i*al aspect of his nails ha3e #eco*e
white. /his characteristic 6ndin& is called:
1. Falf"and"half nails
$. MeesG lines
%. BeauGs lines
'. /erryGs lines
(. MuehrckeGs lines
). Show +<plaination
0
D! 2erritin le3els need to #e: at *ini*u*: a#o3e
which of the seru* le3els to treat iron"
de6ciency related telo&en eRu3iu*.
1. $!n&d8
$. '!n&d8
%. )!n&d8
'. %!n&d8
(. 1!n&d8
). Show +<plaination
B
D1 /he *ost co**on cause for super6cial type
onycho*ycosis is:
1. /richophyton ru#ru*
$. /richophyton *enta&rophytes
B
1))
%. +pider*ophyton -occosu*
'. 2usariu* o<ysporu*
(. Scopulariopsis #re3icalis
). Show +<plaination
D$ /he co**on culprit of pro<i*al white
su#un&ual onycho*ycosis is :
1. Candida al#icans
$. /richophyton ru#ru*
%. /richophyton interdi&itale
'. Scydalidiu* di*idiatu*
(. 2usariu* spp
). Show +<plaination
B
D% ,hat deter*ines the thickness of the nail
plate.
1. Fyponychiu*
$. Eail *atri<
%. Eail #ed
'. Pro<i*al nail fold
(. Eail plate
). Show +<plaination
B
D' ,hich of the followin& syndro*es can present
with woolly or curly hair.
1. B4ornstad syndro*e
$. Citrulline*ia
%. Menkes syndro*e
'. Eoonan syndro*e
(. Eetherton syndro*e
). Show +<plaination
0
D( 2ollicular atrophoder*a is a feature of which of
the followin& conditions.
1. Ba;e< syndro*e
$. Menkes kinky hair syndro*e
%. Papular atrichia
'. /richo"dento"osseous syndro*e
(. /richo"rhino"phalan&eal syndro*e
). Show +<plaination
A
D) A rapid onset of hair &rowth with or without
acco*panyin& 3irili;ation can occur in all of
the followin& conditions +OC+P/:
1. Adrenal adeno*a
$. Adrenal carcino*a
%. Arrheno#lasto*a
'. Kruken#ur& tu*or of the o3ary
(. 93arian cyst
). Show +<plaination
+
DA A patient with psoriasis has pittin& of the nails.
/his 6ndin& is due to in3ol3e*ent of which
part of the nail unit.
1. Pro<i*al *atri<
$. Eail #ed
%. Fyponychiu*
'. Pro<i*al nail fold
(. 0istal *atri<
). Show +<plaination
A
DC A '$ year"old wo*an presents with the
co*plaint of e<cess hair &rowth on her face.
She has nor*al *enses and has recently had
her IannualI e<a* and the note relates nor*al
si;ed o3aries. ,hat is the *ost lo&ical ne<t
step.
1. Check plas*a le3els of
androstenedione and testosterone
$. Send a $1"hydro<ylase en;y*e
de6ciency test
%. Biopsy fro* the *ost aMected area
'. Hefer her to endocrinolo&y
(. 9rder a C/ of the a#do*en
). Show +<plaination
A
DD /his characteristic nail 6ndin& is seen in what
disorder.
1. 8ichen planus
$. Pachyonychia con&enita
%. 0arierGs disease
'. C912 syndro*e
(. CoTn"Siris syndro*e
). Show +<plaination
C
1!
!
/his hair disorder and *utations in A/PAA
=MEK> &ene are found in what
&enoder*atosis.
1. B4ornstad syndro*e
$. MenkeGs kinky hair syndro*e
%. CrandallGs syndro*e
'. Ba;e<Gs follicular atrophoder*a
(. /richothiodystrophy
). Show +<plaination
B
1!
1
0istal su#un&ual onycho*ycosis is *ost often
caused #y:
1. /richophyton *enta&rophytes
$. +pider*ophyton -occosu*
%. /richophyton schoenleinii
'. /richophyton ru#ru*
(. /richophyton *e&ninii
0
1)A
). Show +<plaination
1!
$
,hat is the *ode of inheritance of this
disorder of the hair shaft.
1. Autoso*al do*inant
$. Autoso*al recessi3e
%. O"linked do*inant
'. O"linked recessi3e
(. Sporadic
). Show +<plaination
A
1!
%
A patient with a history of &astrointestinal
polyposis presents with alopecia: &enerali;ed
pi&*entation: and nail dystrophy. ,hich of the
followin& is the *ost likely dia&nosis.
1. Peut;"7e&her syndro*e
$. 5ardner syndro*e
%. Cronkhite"Canada Syndro*e
'. Cowden syndro*e
(. 0yskeratosis con&enita
). Show +<plaination
C
1!
'
,hat is the co**on cause of the Jone hand"
two"footJ syndro*e.
1. /richophyton ru#ru*
$. /richophyton *enta&rophytes = 3ar.
1nterdi&itale>
%. Candida al#icans
'. Scytalidiu* di*idiatu*
(. Scopulariopsis #re3icaulis
). Show +<plaination
A
1!
(
,hat nutritional de6ciency can lead to this nail
6ndin&.
1. ?ita*in B1$
$. ?ita*in C
%. 1ron
'. Ma&nesiu*
(. /hia*ine
). Show +<plaination
C
1!
)
Arsenical poisonin& is associated with what
nail 6ndin&.
1. MuehrckeGs lines
$. MeeGs lines
%. Fapalonychia
'. 9nycholysis
(. 9il spots
). Show +<plaination
B
1!
A
Anonychia is not a feature of which of the
followin& syndro*es.
1. Eail"Patella syndro*e
$. CoTn"Siris syndro*e
%. 099H syndro*e
'. C912 syndro*e
(. Fidrotic ectoder*al dysplasia
). Show +<plaination
+
1!
C
/he epitheliu* that lies on the 3olar surface of
the di&it is the:
1. Eail #ed
$. Eail *atri<
%. Eail plate
'. Fyponychiu*
(. +ponychiu*
). Show +<plaination
0
1!
D
Best dia&nosis of this type of cicatricial
alopecia shown in attached i*a&e is
1. Chronic cutaneous lupus
erythe*atosus
$. 8ichen planopilaris
%. Central centrifu&al cicatricial
alopecia
'. Pseudopelade of BrocL
(. Alopecia *ucinosa
). Show +<plaination
C
11
!
2un&al 6n&er onycholysis usually results fro*: 1. /richophyton ru#ru*
$. /richophyton interdi&itale
%. Candida al#icans
'. Scopulariopsis #re3icaulis
(. 2usariu* spp
). Show +<plaination
C
11
1
Cutaneous si&ns of cortisol e<cess include all
of the followin& +OC+P/:
1. Plethora
$. Atrophicfra&ile skin
%. Striae distensae
'. 0orsocer3icalSupracla3icular fat
pads
(. Peripheral o#esity
). Show +<plaination
+
1)C
11
$
Steatocysto*a *ultiple< and natal teeth are
associated with which of the followin&
conditions.
1. 7adassohn"8ewandowsky
pachyonychia con&enita =/ype 1>
$. 7ackson"Sertole pachyonychia
con&enita =/ype $>
%. Eail"patella syndro*e
'. CoTn"Siris syndro*e
(. Hu#enstein"/ay#i syndro*e
). Show +<plaination
B
11
%
Pili Annulati is associated with which of the
followin& syndro*es.
1. Eetherton
$. P1B10S
%. Citrulline*ia
'. Fidrotic ectoder*al dysplasia
(. Alopecia areata
). Show +<plaination
+
11
'
/he co*#ination of ankylo#lepharon:
ectoder*al dysplasia: and cleft palate with
wiry sparse hair is characteristic of which of
the followin& syndro*es.
1. 2ocal 0er*al Fypoplasia =5olt;
syndro*e>
$. /richo"rhino"phalan&eal Syndro*e
%. Fay",ells Syndro*e
'. +ctrodactyly"+ctoder*al dysplasia"
Cleftin& =++C>
(. /richodentoosseous Syndro*e
). Show +<plaination
C
11
(
A defect in which part of the nail cause a true
leukonychia.
1. Cuticle
$. Fyponychiu*
%. 8unula
'. Eail #ed
(. Eail plate
). Show +<plaination
+
11
)
,hich of the followin& conditions with hair
a#nor*alities is caused #y *utations in a 0EA
helicases.
1. Anhidrotic +ctoder*al 0ysplasia
$. Fidrotic +ctoder*al 0ysplasia
%. K10 Syndro*e
'. Hoth*und"/ho*son Syndro*e
(. 1ncontinentia Pi&*enti
). Show +<plaination
0
11
A
Sellow nail syndro*e is associated with which
of the followin&.
1. Multiple *yelo*a
$. Panhypopituitaris*
%. 0ia#etes *ellitus
'. 0er*atophyte infection
(. 8y*phede*a and #ronchiectasis
). Show +<plaination
+
11
C
Patho&no*onic nails chan&es in F990
syndro*e or Fereditary osteoonychodysplasia
are:
1. Hed and white lon&itudinal #andin&
$. Ptery&iu* in3ersu*
%. Sellow nails
'. Pincer nails
(. /rian&ular lunulae
). Show +<plaination
+
11
D
,hich of the followin& are characteristics of
/richorhinophalan&eal syndro*e.
1. Kinky hair: frontal #ossin&: s*all
widely spaced teeth with poor
ena*el
$. Pal*oplantar keratoder*a:
trichorrhe<is nodosa: sinus infections
%. Shortened phalan&es: sparse hair:
#ul#ous nose
'. Brittle hair: short stature: cere#ellar
ata<ia
(. Sparse 6ne hair: Short e<tre*ities:
1**unode6ciency
). Show +<plaination
C
1$
!
,hich of the followin& is caused #y *utations
in &ap 4unction proteins.
1. Hoth*und"/ho*pson syndro*e
$. Fidrotic ectoder*al dysplasia
%. Anhidrotic ectoder*al dysplasia
'. Eetherton syndro*e
(. Ea<os syndro*e
). Show +<plaination
B
1$ A patient presents with $! nails with a#sent 1. Bpper e<tre*ity ede*a C
1)D
1 cuticles and lunulae: slow &rowth: dystrophic
shape and a yellow hue. ,hich of the followin&
6ndin&s isare associated.
$. Cirrhosis
%. Pleural eMusions
'. Chest pain
(. Pul*onary 6#rosis
). Show +<plaination
1$
$
Splinter he*orrha&e of the nail can #e seen
with which of the followin& parasitic infections.
1. Sca#ies
$. /richinosis
%. Spar&anosis
'. 0racunculiasis
(. 5nathosto*iasis
). Show +<plaination
B
1$
%
A patient with yellow nail syndro*e should #e
e3aluated for syste*ic disease in3ol3in& which
or&an syste*.
1. Fepatic
$. Henal
%. Pul*onary
'. Cardio3ascular
(. Fe*atolo&ic
). Show +<plaination
C
1$. Bullous and ?esicular 0er*atoses
# Question Answers Corre
ct
Answ
er
1 Eickel can #e detected in 4ewelry #y applyin&: 1. 0i*ethyl&lyo<i*e
$. Methylchloroisothia;olinone
%. 0owicil
'. Quinone
(. /hiocyanate
). Show +<plaination
A
$ ,hich pair is not associated with aller&ic cross"
reacti3ity.
1. /hi*erosal : piro<ica*
$. +thylenedia*ine : hydro<y;ine
%. PABA : procaine
'. Balsa* of Peru : cinna*on
(. /hiura* : sulfa dru&s
). Show +<plaination
+
% ,hat is the *ost co**on site of in3ol3e*ent of
this autoi**une #listerin& disease.
1. 9ral *ucosa
$. +yes
%. Skin
'. 5enitalia
(. Easopharyn&eal *ucosa
). Show +<plaination
A
' A child has a defect in type ?11 colla&en and
presents with acral #listers which heal with *ilia
and scarrin&. ,hat is the dia&nosis.
1. Al#opapuloidPasini 3ariant of
dystrophic epider*olysis #ullosa
$. BartGs syndro*e
%. Cockayne"/ouraine disease
'. +pider*olysis #ullosa acLuisita
(. ,e#er"Cockayne
). Show +<plaination
C
( Patients with Senear"Bsher syndro*e are *ost
likely to present with:
1. +rythe*atous papules and
plaLues around the u*#ilicus
$. /ransient 3esicles on the oral
*ucosa
+
1A!
%. Se3erely pruritic &rouped 3esicles
sy**etrically distri#uted
pri*arily on e<tensor surfaces
'. +rythe*a *ultifor*e"like oral
ulcerations which are se3ere
(. +rythe*atous crusts and
hyperkeratotic lesions on the
nose: ears: cheeks: scalp: and
chest
). Show +<plaination
) ,hich is incorrect. 1. /ulipalin : alstroe*eria
$. Brushiol : anacardia
%. SesLuiterpene lactones :
artichokes
'. Bsnic acid : lichen
(. 0iallyl disul6de : 6&
). Show +<plaination
+
A Anti#odies a&ainst type ?11 colla&en are seen in: 1. +pider*olysis #ullosa si*ple<
$. Pe*phi&us erythe*atosus
%. Cicatricial pe*phi&oid
'. +pider*olysis #ullosa acLuisita
(. Bullous pe*phi&oid
). Show +<plaination
0
C Atopic der*atitis is associated with all e<cept: 1. 8chthyosis hystri<
$. Central facial pallor
%. Pityriasis al#a
'. Eipple ec;e*a
(. Fyperlinear pal*s
). Show +<plaination
A
D Perioral e<u#erant &ranulation tissue is so*eti*es
seen in:
1. Cicatricial pe*phi&oid
$. Ferlit;
%. 0uhrin&Gs
'. ,e#er"Cockayne
(. Ste3ens"7ohnson
). Show +<plaination
B
1! Co**on causes of dru&"induced linear 1&A: 1. ?anco*ycin
$. Penicillin
%. Cephalosporins
'. Captopril
(. All of these answers are correct
). Show +<plaination
+
11 ,hich of the followin& concernin& 0e&osG 0isease
is true.
1. After under&oin& *ultiple sta&es:
it resol3es without scarrin&
$. 1t aMects wo*en *ore than *en
%. 5atrointestinal in3ol3e*ent is a
poor pro&nosis
'. 5lucocorticoids are standard of
treat*ent
(. 8a# results indicate a low plas*a
6#rino&en le3el and decreased
platelet a&&re&ation
). Show +<plaination
C
1$ /he ocular for* of cicatricial pe*phi&oid is *ost
likely to #e associated with anti#odies to:
1. Beta"'"inte&rin
$. 8a*inin (
%. BPA&1
'. BPA&$"EC1)A
(. Plectin
). Show +<plaination
A
1% /his is found in #oth des*oso*es and adherens
4unctions:
1. Alpha"catenin
$. 0es*o&lein %
%. 0es*o&lein 1
'. Plako&lo#in
(. 8a*in
). Show +<plaination
0
1' Anti#odies to which anti&en are *ost likely 1. Bullous pe*phi&oid anti&en 11 A
1A1
responsi#le for this disease. $. 0es*o&lein 1
%. 0es*ocollin
'. Keratin (
(. Plako&lo#in
). Show +<plaination
1( An elderly &entle*an with a history of
hypertension and a thy*o*a: presents to the
+*er&ency Hoo* with oral and con4uncti3al
erosions and he*orrha&ic #ullae on his hands and
feet. /hese 6nds are seen in:
1. Cicatricial pe*phi&oid
$. SweetJs syndro*e
%. /o<ic epider*al necrolysis
'. Paraneoplastic pe*phi&us
(. +rythe*a *ultifor*e
). Show +<plaination
0
1) ,hich of the followin& is true of herpes
&estationis.
1. 0e*onstrates anti#odies to the C"
ter*inal do*ain of BPA&$
$. Fas hi&her freLuency in fe*ales
with F8A"0Q$
%. 1s associated with 5ra3eGs disease
'. Bsually occurs in the 6rst
tri*ester of pre&nancy
(. Shows su#epider*al #ullae
*ostly with neutrophils
). Show +<plaination
C
1A Characteristic eosinophilic a#scesses are seen in: 1. Bullous dru&
$. Pe*phi&us 3e&etans
%. Ferpes &estationis
'. 1ncontinentia pi&*enti
(. Paraneoplastic pe*phi&us
). Show +<plaination
B
1C At what le3el is the #lister separation plane in
linear 1&A der*atosis.
1. 5ranular layer
$. Supra#asal layer
%. Basal layer
'. 8a*ina lucida
(. 8a*ina densa
). Show +<plaination
0
1D A )! year old &entle*an presents with a recurrent
pustular eruption. Biopsy de*onstrates
su#corneal pustules with a#undant neutrophils
and a seru* protein electrophoresis shows a
*onoclonal 1&A &a**opathy. /he autoanti&en
responsi#le for this condition:
1. 0es*o&lein 1
$. 0es*ocollin 1
%. 0es*oplakin
'. Plako&lo#in
(. Beta ' inte&rin
). Show +<plaination
B
$! Anti#odies in chronic disease of childhood disease:
*ap to the:
1. Basal layer
$. 8a*ina lucida
%. 8a*ina densa
'. Su#la*ina densa
(. 8a*ina lucida and su#la*ina
densa
). Show +<plaination
+
$1 A %( year"old dentist presents with tin&lin& in his
6n&ertips. ,hat aller&en is *ost likely to cause
this der*atitis.
1. Methyl *ethacrylate
$. Paraphenylenedia*ine
%. Colophony
'. /hiura* *i<
(. +thylenedia*ine dihydrochloride
). Show +<plaination
A
$$ ,hich of the followin& proteins is a 1)!k0a
cadherin.
1. 0es*o&lein %
$. 0es*o&lein 1
%. 0es*oplakin 1
'. +n3oplakin
(. Plectin
). Show +<plaination
B
$% ,hich of the followin& i**unosuppressi3e a&ents
has #een *ost eMecti3e in cicatricial pe*phi&oid.
1. Cyclophospha*ide
$. A;athioprine
%. Mycophenolate *ofetil
'. Cyclosporine
(. Methotre<ate
). Show +<plaination
A
$' Ferpes &estationis is e<acer#ated #y: 1. 9ral contracepti3es +
1A$
$. Menstruation
%. /hird tri*ester
'. Postpartu* state
(. All of these answers are correct
). Show +<plaination
$( 0er*atitis herpetifor*is is associated with: 1. F8A"Cw)
$. F8A"B$A
%. F8A"0H'
'. F8A"0Q1
(. F8A"0H%
). Show +<plaination
+
$) ,hat is the anti&en found in the 3ariant of
cicatrical pe*phi&oid that is associated with
internal *ali&nancies.
1. BPA&1
$. BPA&$
%. /ype ?11 colla&en
'. +pili&rin
(. Keratins ( @ 1'
). Show +<plaination
0
$A /he rate li*itin& step in the porphyria pathway is
*ediated #y the en;y*e:
1. 2errochetalase
$. A8A dehydratase
%. A8A synthase
'. Broporphyrino&en decar#o<ylase
(. Porpho#ilino&en dea*inase
). Show +<plaination
C
$C Co**on dru&s causin& S7S/+E include all e<cept: 1. Sulfona*ides
$. Car#a*a;epi*e
%. Allopurinol
'. 9<ica*
(. Colchicine
). Show +<plaination
+
$D ,hich association is incorrect. 1. +pider*olysis #ullosa acLuisita :
in-a**atory #owel disease
$. 0er*atitis herpetifor*is : s*all
#owel ly*pho*a
%. Paraneoplastic pe*phi&us :
Castle*an[s
'. Ferpes &estationis : *enopause
(. Porphyria cutanea tarda :
he*ochro*atosis
). Show +<plaination
0
%! ,hich of the followin& is true of a phototo<ic
reaction.
1. HeLuires prior sensiti;ation of
photoaller&en in suscepti#le
indi3iduals
$. Photoaller&en *ust #ind to carrier
protein
%. 0e3elops after repeated
e<posures
'. Produces an ec;e*atous reaction
(. Hesults in direct tissue in4ury
). Show +<plaination
+
%1 ,hich of the followin& is the *ost co**on
photoaller&en.
1. octyl di*ethyl PABA
$. 0ihydro<yacetone
%. Ben;ophenone
'. 9<y#en;one
(. &lyceryl thio&lycolate
). Show +<plaination
0
%$ Bullous dia#eticoru* typically presents on the: 1. 2ace
$. Chest
%. Ar*s
'. 8e&s
(. 5roin
). Show +<plaination
0
%% +pider*olysis #ullosa si*ple< is caused #y
*utations in:
1. Keratins 1@1!
$. Keratins 1@D
%. Keratins (@1'
'. Keratins )a @1)
C
1A%
(. Keratins K$e@1!
). Show +<plaination
%' 2or*aldehyde releasers include all e<cept: 1. Methylchoroisothia;olinone
$. 5er*all
%. Quaterniu* J 1(
'. 0owicil
(. 0M0M hydantoin
). Show +<plaination
A
%( 2i#er&lass der*atitis can #e pre3ented #y: 1. ,ater
$. Acetic acid (N
%. Sodiu* chloride
'. Alkali
(. /alcu* powder
). Show +<plaination
+
%) ,hich type of porphyria disease is *ost likely to
#e associated with cholelithiasis.
1. Acute inter*ittent porphyria
$. Con&enital erythropoeitic
porphyria
%. Fereditary coproporphyria
'. +rythropoetic protoporphyria
(. ?arie&ate porphyria
). Show +<plaination
0
%A /he la*ina densa is pri*arily co*posed of. 1. Conne<ins
$. Plectin
%. Colla&en O?11
'. Colla&en ?11
(. Colla&en 1?
). Show +<plaination
+
%C +tyhlenedia*ine dihydrochloride is known to
cross"react with all the followin& su#stances
e<cept.
1. Eeo*ycin
$. A*inophylline
%. Pro*etha;ine
'. Mecli;ine
(. Fydro<y;ine
). Show +<plaination
A
%D /he A#soe"Fansen si&n as applies to #lister
for*ation refers to
1. 8ateral slippin& of the epider*is
when perilesional is ru##ed
$. 8ateral dissection of the #lister
when pressure is applied directly
to a #lister
%. Blister for*ation followin&
strokin& of the lesion
'. Blister induction with incised
trau*a to skin
(. Blister for*ation after
cryosur&ery
). Show +<plaination
B
'! /he C"ter*inal do*ain of BPA&$ is tar&eted in: 1. Bullous pe*phi&oid
$. Cicatricial pe*phi&oid
%. 1&A pe*phi&us
'. 0uhrin&Js disease
(. Pe*phi&oid &estationis
). Show +<plaination
B
'1 /he *ost co**on cause of contact der*atitis in
the Bnited States is:
1. Fair dyes
$. Eickel
%. Eail lacLuers
'. /o<icodendrons
(. Hu##er
). Show +<plaination
0
'$ A patient who works in a photo&raphy de3elopin&
la# co*plains of ec;e*atous der*atitis on his
hands. ,hich one of the followin& che*icals is he
*ost likely aller&ic to.
1. Mercapto#en;othia;ole
$. 8anolin
%. +po<y resin
'. Parapheylenedia*ine
(. Colophony
). Show +<plaination
0
'% Bullous lupus erythe*atosus is *ost co**only
associated with anti#odies to:
1. /ype O11 colla&en
$. /ype ?11 colla&en
B
1A'
%. Plectin
'. 0es*o&lein 1
(. 8a*inin (
). Show +<plaination
'' Pinus palustris is the source of: 1. Brea
$. 0"li*onene
%. Quinones
'. 8actones
(. A#ietic acid
). Show +<plaination
+
'( ,hich of the followin& for*s of epider*olysis
#ullosa is autoso*al recessi3e.
1. ,e#er"Cockayne
$. 0owlin&"Meara
%. 7unctional +B with pyloric atresia
'. +B si*ple< with *uscular
dystrophy
(. Fyperplastic cockayne"touraine
). Show +<plaination
C
') /his *edicine causes de&ranulation of *ast cells 1. ESA10s
$. ASA
%. opiates
'. poly*i<in B
(. All of these answers are correct
). Show +<plaination
+
'A 8ate< aller&y can cross"react with all e<cept: 1. A3ocado
$. Banana
%. Kiwi
'. Chestnut
(. Artichoke
). Show +<plaination
+
'C 8einerGs disease =erythroder*a desLua*ati3u*> is
associated with:
1. C("D de6ciency
$. Eu*erous infections
%. 0iarrhea
'. Eu*erous infections and diarrhea
(. All of these answers are correct
). Show +<plaination
0
'D /he croton plant is irritatin& secondary to: 1. Calciu* o<alate
$. /hiocyanate
%. Protoane*onin
'. Phor#ol esters
(. Capsaicin
). Show +<plaination
0
(! Ferpes &estationis is *ost co**only associated
with:
1. 5ra3eGs
$. Fashi*otoGs
%. 0ia#etes
'. 8upus
(. Hheu*atoid arthritis
). Show +<plaination
A
(1 Clu*ped tono6la*ents are seen on electron
*icroscopy in:
1. 0owlin&"Meara
$. ,e#er"Cockayne
%. 5untherJs
'. Ea<os disease
(. ?ohwinkelJs syndro*e
). Show +<plaination
A
($ ,hat is the *ost co**on cause of this entity. 1. 0ru&s
$. 1nfections
%. Mali&nancies
'. 1diopathic
(. B? e<posure
). Show +<plaination
A
(% 5ap 4unctions consist of: 1. 8a*inin
$. Plectin
%. Bncein
'. 2ila&rin
(. Conne<ins
). Show +<plaination
+
1A(
(' /his is deri3ed fro* Myro<ylon pereirae: 1. /hi*erosol
$. Aniline dyes
%. Balsa* of Peru
'. Colophony
(. /hiura*
). Show +<plaination
C
(( ,hich of the followin& a&ent=s> has #een *ost
eMecti3e in treatin& se3ere ocular cicatricial
pe*phi&oid.
1. Cyclophospha*ide
$. Mycophenolate *ofetil
%. Cyclophospha*ide P
corticosteroids
'. Cyclosporin
(. A;athioprine
). Show +<plaination
C
() Chloracne *ay #e secondary to e<posure to: 1. Chloroacetophenone
$. Fydrochloric acid
%. Fydrocar#ons
'. 0io<in
(. Methylchloroisothia;olinone
). Show +<plaination
0
(A Ferpes &estationis is *ost co**only associated
with:
1. 8y*pho*a
$. Multiparity
%. 5ra3eGs disease
'. 1n-a**atory #owel disease
(. 8upus
). Show +<plaination
C
(C ,hich for* of epider*olysis #ullosa presents with
&enerali;ed #ullae: a#sent nails: dysplastic teeth
=due to ena*el defects>: nonhealin& &ranulation
tissue periorally: and is often fatal #y a&e %"'.
1. ,e#er"cockayne
$. Ferlit;
%. Eon"Ferlit;
'. Fyperplastic cockayne"touraine
(. Al#apapuloid Pasini 3ariant
). Show +<plaination
B
(D ,hich of the followin& is not a for*aldehyde"
releasin& preser3ati3e.
1. Bronopol
$. Methylchloroisothia;inolone
%. Quaterniu*"1(
'. 1*ida;olidinyl urea
(. 0M0M hydantoin
). Show +<plaination
B
)! /he epider*olysis #ullosa acLuisita anti&en is: 1. A trans*e*#rane protein
$. An intracellular protein
%. A des*oso*al protein
'. 8ocated in the la*ina lucida
(. An anchorin& 6#ril
). Show +<plaination
+
)1 ,hich type of porphyria *anifests with peripheral
neuropathy: colicky a#do*inal pain: #ut E9
cutaneous sy*pto*s.
1. Acute 1nter*ittent Porphyria
$. 5untherGs disease
%. ?arie&ate porphyria
'. Fereditary Copropophyria
(. +rythropoietic protopophyria
). Show +<plaination
A
)$ 0irect i**uno-uorescent studies in chronic
#ullous disease of childhood is *ost likely to show:
1. 1&a depostion in the super6cial
#lood 3essels
$. 8inear 1&5 at the #ase*ent
*e*#rane
%. 8inear 1&A at the #ase*ent
*e*#rane
'. 5ranular 1&5
(. 8inear C% at the #ase*ent
*e*#rane
). Show +<plaination
C
)% Circulatin& autoanti#odies to type O?11 colla&en
are *ost characteristic of which disease.
1. +pider*olysis #ullosa accLuisita
$. Ferpes &estationis
%. Pe*phi&us 3ul&aris
'. Pe*phi&us foliacious
(. Paraneoplastic pe*phi&us
). Show +<plaination
B
1A)
)' A wo*an in her $nd tri*ester of pre&nancy
presents to clinic with urticarial plaLues and
papules around her u*#ilicus: chest and
e<tre*ities. /ense 3esicles are present within a
few of the erythe*atous plaLues. /his
wo*anXaYs condition is *ost co**only
associated with:
1. 8y*pho*a
$. Multiparity
%. 5ra3eX Ys 0isease
'. 1n-a**atory Bowel 0isease
(. 8upus
). Show +<plaination
C
)( /he picture shown is considered to #e dia&nostic
for what type of epider*olysis #ullosa
1. 7unctional epider*olysis #ullosa"
Eon Ferlit; type
$. 7unctional epider*olysis #ullosa"
Ferlit; type
%. 0owlin&"Meara for* of
+pider*olysis Bullous si*ple<
'. 0o*inant dystrophic
epider*olysis #ullosa
(. Hecessi3e dystrophic
epider*olysis #ullosa
). Show +<plaination
+
)) Co**on cause=s> of dru&"induced pe*phi&us
foliaceus:
1. Captopril
$. Penicilla*ine
%. Captopril and penicilla*ine
'. Methotre<ate
(. 0ilantin
). Show +<plaination
C
)A ,hich autoanti#odies would *ost likely #e found
in an indi3idual with eye 6ndin&s without any
cutaneous in3ol3e*ent.
1. Alpha ) #eta ' inte&rin
$. Bullous pe*phi&oid anti&en 1
%. Bullous pe*phi&oid anti&en $
'. 0es*ocollin
(. 8a*inin (
). Show +<plaination
A
)C ,hich pair is incorrect. 1. 0es*o&lein 1 : 1)! k0a
$. 0es*oplakin 1 : $(! k0a
%. /ype ?11 colla&en : $D! k0a
'. /ype O?11 colla&en: 1C! k0a
(. +n3oplakin : 1D! k0a
). Show +<plaination
+
)D Patients with epider*olysis #ullosa acLuisita ha3e: 1. A defect in plectin
$. A defect in colla&en O?11
%. Anti#odies to colla&en O?11
'. Anti#odies to colla&en ?11
(. A defect in la*inin (
). Show +<plaination
0
A! A one"day old infant presents with papules and
pustules on the face: trunk: and pro<i*al
e<tre*ities. Pal*s and soles are spared. /he
patient is otherwise doin& well. A #iopsy shows
nu*erous eosinophils. /he dia&nosis is:
1. Acropustulosis of infancy
$. Ferpes infection
%. +rythe*a to<icu* neanotoru*
'. Sca#ies
(. /ransient neonatal pustular
*elanosis
). Show +<plaination
C
A1 ,hich pair is incorrect. 1. ,rinkle"resistance : for*aldehyde
$. Chewin& &u* : colophony
%. Para#ens : artichokes
'. 5lyceryl thio&lycolate : acid
per*anent wa3e
(. Per*ethrin : chrysanthe*u*
). Show +<plaination
C
A$ Pe*phi&us erythe*atosus: 1. 1s also called Fallopeau syndro*e
$. May #e an a#orti3e for* of
su#corneal pustulosis
%. 1s often in a *alarse#orrheic
distri#ution
'. 0oes not ha3e linear 1&5 and C%
at the #ase*ent *e*#rane ;one
(. All of these answers are correct
). Show +<plaination
C
1AA
A% /he 3ector of fo&o sel3a&e* *ay #e: 1. /riato*a
$. Si*uliu*
%. Ci*e<
'. 9rnithodorus
(. Mus
). Show +<plaination
B
A' /he *ost co**on *ali&nancy associated with
paraneoplastic pe*phi&us is:
1. Eon"Fod&kinGs ly*pho*a
$. Chronic ly*phocytic leuke*ia
%. Multiple *yelo*a
'. Acute *yelocytic leuke*ia
(. Fod&kinGs ly*pho*a
). Show +<plaination
A
A( /he defect in 4unctional epider*olysis #ullosa
occurs at the:
1. 5ranular layer
$. Spinous layer
%. 8a*ina lucida
'. 8a*ina densa
(. Su#la*ina densa
). Show +<plaination
C
A) A $!"year"old fe*ale presents with an aller&ic
contact der*atitis to a perfu*e containin& 8ily of
the 3alley. ,hat is the causati3e aller&en.
1. Cinna*ic acid
$. ?anillin
%. Fydro<ycitronellal
'. Atranorin
(. +3ernic acid
). Show +<plaination
C
AA ,hich neoplas* is the *ost co**on cause of
paraneoplastic pe*phi&us.
1. /hy*o*a
$. C88
%. Castle*anGs disease
'. Hetroperitoneal sarco*a
(. Eon"Fod&kinGs ly*pho*a
). Show +<plaination
+
AC ,hich of the followin& aller&ens is a non"
for*adelhyde releasin& preser3ati3e with a low
sensiti;ation potential.
1. Methylisothia;olone
$. Para#en
%. Bronopol
'. Quterniu*"1(
(. 0M0M hydantoin
). Show +<plaination
B
AD Patients with this disorder *ay de3elop
e<a&&erated reactions to insect #ites:
1. Chronic ly*phocytic leuke*ia
$. Bullous pe*phi&oid
%. 8upus erythe*atosus
'. Atopic der*atitis
(. 1ncontinentia pi&*enti
). Show +<plaination
A
C! ,hat is the anti&en associated with der*atitis
herpetifor*is.
1. /issue trans&luta*inase
$. +pile&rin
%. 0es*ocollin
'. 0es*o&lein %
(. Periplakin
). Show +<plaination
A
C1 ,hat percenta&e of der*atitis herpetifor*is
patients are asy*pto*atic #ut ha3e 6ndin&s
consistent with celiac sprue on &astrointestinal
#iopsy.
1. (N
$. 1(N
%. '!N
'. A!N
(. D(N
). Show +<plaination
+
C$ ,hich of the followin& is 8+AS/ 81K+8S to cross
react with /o<icodendron plant der*atitis.
1. 7apanese lacLuer tree
$. Cashew nut
%. Man&o rind
'. 5in&ko tree
(. Kiwi
). Show +<plaination
+
C% /he di*ethyl&lyo<i*e test is used to detect the
presence of:
1. 5old
$. Sil3er
%. Mercury
'. Eickel
(. 8ate<
0
1AC
). Show +<plaination
C' ,hich of the followin& proteins is typically E9/
found to #e anti&enic in paraneoplastic
pe*phi&us.
1. BPA&1
$. BPA&$
%. 0es*oplakin
'. +n3oplakin
(. Periplakin
). Show +<plaination
B
C( ,hich pair is incorrect. 1. 0er*atitis herpetifor*is :
&ranular 1&A
$. 8ichen planus : linear C%
%. Bullous pe*phi&oid : linear C%
'. Syste*ic lupus erythe*atosus :
linear 1&5
(. 1&A pe*phi&us: intercellular 1&A
). Show +<plaination
B
C) Paraneoplastic pe*phi&us: 1. 1s characteri;ed #y a
patho&no*onic $(! k0a anti&en
$. 1s *ost often seen in association
with lun& cancer
%. 0oes not re*it e3en if the cancer
is e<cised co*pletely
'. May #e caused #y a #eni&n
neoplas*
(. All of these answers are correct
). Show +<plaination
0
CA Patients with late< aller&y are 8+AS/ 81K+8S to
de3elop a reaction to:
1. Cashew
$. A3ocado
%. Chestnut
'. Banana
(. Kiwi
). Show +<plaination
A
CC A patient de3elops erythe*a and 3esiculation on
his dorsal foot that spares the toewe#s and soles
after #uyin& a new pair of shoes. ,hat is the *ost
likely aller&en.
1. /hiura* *i<
$. Car#a*ates
%. 8ate<
'. Mercapto#en;othia;ole
(. 2or*aldehyd&e
). Show +<plaination
0
CD 1rritation of the hand produced #y capsaicin can
#e relie3ed #y application of
1. ,ater
$. Acetic acid (N
%. Sodiu* chloride
'. Alkali
(. /alcu* powder
). Show +<plaination
B
D! ,hich of the followin& su#stances is known to
cause a delayed positi3e patch test reaction.
1. 5old
$. Eickel
%. Bacitracin
'. 2ra&rance *i<
(. Hosin
). Show +<plaination
A
D1 ,hich of the followin& can #e responsi#le for
contact der*atitis to K"S 7elly.
1. 8anolin alcohol
$. Budesonide
%. Alpha tocopherol
'. Propylene &lycol
(. /riclosan
). Show +<plaination
0
D$ /he anti&en in linear 1&A is: 1. BPA&1
$. Plectin
%. DAk0a part of BPA&$
'. 8a*inin (
(. Alpha"): #eta inte&rin
). Show +<plaination
C
D% ,hich pair is incorrect. 1. +yedrops : thi*erosal
$. +ar drops : neo*ycin
%. /heophylline : ethylenedia*ine
'. Anta#use : thiura*
+
1AD
(. Co#ala*in : #alsa*
). Show +<plaination
D' /he pri*ary autoanti&en in pe*phi&oid
&estationis is
1. 0es*oplakin
$. BPA51
%. BPA5$
'. Plako&lo#in
(. Anchorin& 6#rils
). Show +<plaination
C
D( ,hich of the followin& is known as Iprickly heatI. 1. Miliaria crystallina
$. Miliaria ru#ra
%. Miliaria profunda
'. 5ro3erGs disease
(. 2o<"2ordyce disease
). Show +<plaination
B
D) Patients with 0uhrin&Gs disease are *ost likely to
ha3e:
1. Mutations in plectin
$. Mutations in la*inin (
%. Mutations in trans&luta*inase 1
'. Anti#odies to trans&luta*inase %
(. Anti#odies to BPA&$
). Show +<plaination
0
DA 1n staphylococcal scalded skin syndro*e: the
e<foliati3e to<in clea3es:
1. 0es*o&lein 1
$. 0es*o&lein %
%. 0es*ocollin 1
'. 0es*ocollin %
(. BpA&$
). Show +<plaination
A
DC ,hich type of epider*olysis #ullosa has the
&reatest risk of de3elopin& sLua*ous cell
carcino*as.
1. ,e#er"Cockayne
$. 0owlin&"Meara
%. Ferlit;
'. +B Si*ple< with *uscular
dystrophy
(. Fallopeau"Sie*ens type of
recessi3e dystrophic +B
). Show +<plaination
+
DD 2ecal isocoproporphyrin is seen in: 1. Porphyria cutanea tarda
$. Farderoporphyria
%. ?arie&ate porphyria
'. Acute inter*ittent porphyria
(. Coproporphyria
). Show +<plaination
A
1!
!
1n Brunstin&"Perry pe*phi&oid: the recrurrent
crops of #listers are *ost likely to appear on:
1. 5enitals
$. Pal*s and soles
%. B*#ilicus
'. Fead and neck
(. Buttocks
). Show +<plaination
0
1!
1
Bullous pe*phi&oid anti&en 1 =BPA&1> is a
*e*#er of this fa*ily:
1. Cadherin
$. 1nte&rin
%. 1nter*ediate 6la*ent
'. Plakin
(. Selectin
). Show +<plaination
0
1!
$
Bullous lesions are seen in: 1. Con&enital syphilis
$. Pri*ary syphilis
%. Secondary syphilis
'. /ertiary syphilis
(. All of these answers are correct
). Show +<plaination
A
1!
%
/ransient #ullous disorder of childhood has a
defect in:
1. Alpha)"inte&rin
$. Plectin
%. BPA&$
'. +pili&rin
(. Colla&en ?11
). Show +<plaination
+
1! /he *ost i*portant &roup of disease linked with 1. 8y*phoproliferati3e disorders A
1C!
' the patho&enesis of paraneoplastic pe*phi&us in
adults is
$. Colerectal adenocarcino*a
%. Breast Cancer
'. Sarco*as
(. Melano*a
). Show +<plaination
1!
(
Sou are consulted on this patient who has 4ust
under&one an orthopedic spinal procedure. ,hat
is true of this patient.
1. She should a3oid #ananas
$. She is aller&ic to #etadine
%. She is *ost likely ha3in& an
aller&ic response to an anti#iotic
'. She has *iliaria crystallina
(. /his is not related to her
procedure
). Show +<plaination
A
1!
)
,hat is the en;y*e defect in 5untherGs disease. 1. Porpho#ilino&en dea*inase
$. Broporphyrino&en synthetase 111
%. Broporphyrino&en decar#o<ylase
'. 2errochetalase
(. Protoporphyrino&en o<idase
). Show +<plaination
B
1!
A
Cicatricial pe*phi&oid can #e induced #y: 1. A*ino&lycosides
$. Ben;ene
%. Clonidine
'. ?anco*ycin
(. Cipro-o<acin
). Show +<plaination
C
1!
C
/he #est 6rst line treat*ent for der*atitis
herpetifor*is is:
1. Methotre<ate
$. 0apsone
%. Colchicine
'. Prednisone
(. 1?15
). Show +<plaination
B
1!
D
I9rientalI ti&er #al* cross"reacts with: 1. Balsa* of Peru
$. Slan&"Slan& oil
%. Eeo*ycin
'. 8anolin
(. Hosin
). Show +<plaination
A
11
!
,hich steriod screenin& a&ent should #e used
when an aller&ic contact der*aititis is suspected
to hydrocortisone.
1. 5lutaral
$. /i<ocortol"$1"pi3alate
%. Budesonide
'. Fydrocortisone"1A"#utyrate
(. Ben;alkoniu* chloride
). Show +<plaination
B
11
1
5allstones are associated with: 1. +rythropoietic protoporphyria
$. Fepatoerythropoietic porphyria
%. ?arie&ate porphyria
'. Coproporphyria
(. Farderoporphyria
). Show +<plaination
A
11
$
Mutations in #eta"catenin are *ost co**only
associated with:
1. Ea<os disease
$. Bullous pe*phi&oid
%. Pilo*atrico*as
'. +ctoder*al dysplasia with skin
fra&ility
(. 9cular cicatricial pe*phi&oid
). Show +<plaination
C
11
%
,hich of the followin& is the *ost co**on cause
of contact der*atitis due to a for*aldehyde
releasin& preser3ati3e.
1. Para#en *i<
$. /hi*erosal
%. Quaterniu* 1(
'. 1*ida;olidinyl urea
(. Paraphenylenedia*ine
). Show +<plaination
C
11
'
Clea3a&e of this adhesion *olecule is seen in
Staphylococcal Scalded Skin Syndro*e:
1. 0es*oplakin 1
$. 0es*oplakin $
%. 0es*o&lein 1
C
1C1
'. 0es*o&lein %
(. 0es*oplakin 1 and des*oplakin
$
). Show +<plaination
11
(
/his is associated with deafness: 1. Claudin
$. Cadherin
%. Conne<in
'. 0es*in
(. 0es*oplakin
). Show +<plaination
C
11
)
+ach of the followin& is true a#out anti"p$!!
pe*phi&oid e<cept:
1. Hesponsi3e to dapsone
$. Su#epider*al #ullae
%. $!!"kd anti&en
'. features of linear 1&A disease
(. *ucosal in3ol3e*ent
). Show +<plaination
+
11
A
,hich of the followin& che*icals is the *ost
co**on cause of shoe contact der*atitis.
1. /hiura* *i<
$. $"Mercapto#en;othia;ole
%. Car#a *i<
'. Mi<ed dialkyl thioureas
(. 2or*aldehyde
). Show +<plaination
B
11
C
Papillary der*al deposits of 1&A and a papillary
der*al in6ltrate of neutrophils is dia&nostic of:
1. SweetGs syndro*e
$. 8eukocytoclastic 3asculitis
%. 0er*atitis herpetifor*is
'. 8inear 1&A der*atosis
(. Bullous pe*phi&oid
). Show +<plaination
C
11
D
Anti#odies in so*e for*s of Ste3ens"7ohnson #ind
to:
1. 0es*oplakin 1
$. 0es*o&lein 1
%. 0es*o&lein %
'. Plako&lo#in
(. 0es*oplakin 1 and des*o&lein %
). Show +<plaination
A
1$
!
/his disease is inherited in an O"linked recessi3e
*anner:
1. Chronic &ranulo*atous disorder
$. 7o#Js syndro*e
%. 0owlin&"Meara
'. Mon&o*eryJs syndro*e
(. /reacher"Collins
). Show +<plaination
A
1$
1
A (D"year old fe*ale has erythe*a and
3esiculation in an area of application of tincture of
#en;oin. ,hich aller&en is she also *ost likely
aller&ic to.
1. A**oniu* persulfate
$. Black ru##er *i<
%. Balsa* of Peru
'. +u&enol
(. +po<y resin
). Show +<plaination
C
1$
$
,hich of the associated anti&ens for this condition
has #een associated with colon cancer.
1. Anti"epili&rin
$. DA k0 linear 1&A der*atosis
anti&en
%. 0es*oplakin
'. Bullous pe*phi&oid anti&en $
(. Beta"' inte&rin
). Show +<plaination
A
1$
%
,hich of the followin& adhesion *olecules are
i*portant for *aintainin& adhesion #etween
keratinocytes.
1. Selectins
$. 1nte&rins
%. Cadherins
'. 5lycans
(. 1**uno&lo#ulin superfa*ily
). Show +<plaination
C
1$
'
/h$"related cytokines include: 1. 181!
$. 12E&a**a
%. 12Ealpha
'. 181! and 12E&a**a
(. All of these answers are correct
). Show +<plaination
A
1C$
1$
(
Aller&ic contact der*atitis is characteri;ed
histolo&ically #y:
1. Psoriasifor* der*atitis
$. 8ichenoid in6ltrate
%. Spon&iosis
'. Parakeratosis
(. 5ranulo*a
). Show +<plaination
C
1$
)
9cular cicatricial pe*phi&oid has anti#odies
a&ainst:
1. 5a**a"catenin
$. Peripherin
%. Beta'"inte&rin
'. Kalinin
(. ?inculin
). Show +<plaination
C
1$
A
1n penicilla*ine"induced pe*phi&us: the split is
*ost often:
1. Su#corneal
$. 1ntraspinous
%. Supra#asal
'. 1ntraepider*al and su#epider*al
(. Su#epider*al
). Show +<plaination
A
1$
C
+pider*olysis #ullosa si*ple< with *uscular
dystrophy is associated with a *utation in:
1. 8a*inin (
$. Plectin
%. colla&en ?11
'. uncein
(. alpha ) #eta inte&rin
). Show +<plaination
B
1$
D
,hich of the followin& contains the sa*e aller&en
as poison su*ac.
1. Man&o fruit
$. Bra;ilian Pepper /ree
%. Balsa* of Peru
'. Ha&weed
(. Artichoke
). Show +<plaination
B
1%
!
0irect i**uno-uorescent studies in a patient with
#ullous pe*phi&oid is *ost likely to show:
1. 8inear 1&A at the #ase*ent
*e*#rane
$. 8inear C% at the #ase*e*ent
*e*#rane
%. 5ranular 1&A in der*al papillae
'. 1ntercellular 1&5' throu&hout the
epider*is
(. C% in the der*al papillae
). Show +<plaination
B
1%
1
,hat is the *ost co**on aller&en causin&
aller&ic contact der*atitis.
1. Eickel
$. Bacitracin
%. 2or*aldehyde
'. Quaterniu*"1(
(. Eeo*ycin
). Show +<plaination
A
1%
$
A child de3elops an aller&ic reaction at the site of
an in-uen;a 3accine. /o which of the followin&
su#stances *ay she #e aller&ic to.
1. 8anolin
$. /hi*erosol
%. +thylenedia*ine dichloride
'. /riclosan
(. 5luteraldehyde
). Show +<plaination
B
1%
%
/he a&ent *ost likely to cause pseudoporphyria
is:
1. ESA10Gs
$. Penicillin
%. Beta"#lockers
'. ?anco*ycin
(. Ace"inhi#itors
). Show +<plaination
A
1C%