Aarkstore Enterprise

Stem Cell Research Products - Opportunities, Tools, and

Technologies






Summary
Stem cells are primitive cells found in all multi-cellular organisms that are characterized by self-renewal and the capacity
to differentiate into any mature cell type.
Stem cells are still a relatively new discovery, as the first mouse embryonic stem cells were derived from embryos in
1981, but it was not until 1995 that the first successful culturing of embryonic stem cells from non-human primates
occurred and not until November 1998 that a technique was developed to isolate and grow embryonic stem cells from
human blastocysts. In 2006, induced pluripotent stem cells were produced for the first time from mouse cells and in
2007 they were produced from human cells. Furthermore, it was not until 2008 that the first full transplant of a human
organ grown from adult stem cells was performed when a section of trachea was successfully transplanted into an adult
woman in Spain.
As of 2014, several broad categories of stem cells exist, including:
Embryonic stem cells, derived from blastocysts
Fetal stem cells, obtained from fetuses
Post-natal stem cells, derived from newborn tissues
Adult stem cells, found in adult tissues including Hematopoietic stem cells, Mesenchymal stem cells, and Neural stem
cells
Cord blood stem cells, isolated from umbilical tissue
Dental stem cells, derived from deciduous teeth
Induced pluripotent stem cells, reprogrammed from adult cells
Browse Full Report @
http://www.aarkstore.com/healthcare/53012/stem-cell-research-
products-opportunities-tools-and-technologies
Published: Jun 2014| No. Of Pages: 155 Pages
PDF: $ 3495 | Hard Copy: $ 3545
Site License: $ 4495 | Enterprise Wide License: $ 5495

Aarkstore Enterprise




Cancer stem cells, which give rise to clonal populations of cells that form tumors or disperse in the body
Animal stem cells, derived from non-human sources
The past 10 years have also witnessed the production of novel stem cell types, including piPSCs, R-NSCs, and VSELs.
Together, this evidence suggests that additional types of stem cells will likely be discovered, each representing new
opportunities for research product development. Clearly, laboratory research into stem cell derivation, manipulation,
and application is rapidly expanding.
To facilitate research resulting from these advances, a large and diverse stem cells products market has emerged. Large
companies selling stem cell research products include Thermo Fisher Scientific (now merged with Life Technologies), BD
Biosciences, EMD Millipore, Sigma Aldrich, and STEMCELL Technologies, as well as over one hundred other suppliers.
Currently, the following product categories compose the majority of global stem cell product sales:
Primary antibodies to stem cell antigens
Bead-based stem cell separation systems
Fluorescent-based labeling and detection
Stem cell protein purification and analysis tools
Tools for DNA and RNA-based characterization of stem cells
Isolation/characterization services
Stem cell culture media and reagents
Stem cell specific growth factors and cytokines
Tools for stem cell gene regulation
Stem cell services and mechanisms for in vivo and in vitro stem cell tracking
Expansion/differentiation services for stem cell media and RNAi
Stem cell lines
Furthermore, to sell products in the stem cell market, it is critical to understand the research applications for which stem
cells are being studied. One area of study is the use of stem cells to understand and treat birth disorders. However, of
greater interest to researchers is the potential for use of stem cells in regenerative medicine to treat conditions ranging
from diabetes, to cardiovascular disease and neurological disorders.
Pharmaceutical companies have intense interest in the ability to use stem cells to improve drug target validation and
toxicology screening. Therefore, it is important for companies interested in stem cell therapy applications to understand
underlying market forces, and in particular, to consider progressive areas of stem cell research as opportunistic areas for
drug and therapy development. This report presents a range of topics of interest to these companies as well, including

Aarkstore Enterprise




how advances in stem research can reveal potential new drug targets, improve methods of drug delivery, and provide
personalized treatment strategies.
The key areas that account for the majority of applied stem cell research include:
Regenerative Medicine - Reversal of injury or disease
Drug Target Validation and Drug Delivery - Treatment of disease
Toxicology Screening - Drug safety and efficacy assessment
Understanding and Treatment of Birth Disorders - Natal repair
You can order full Report with TOC and for Sample page visit @
http://www.aarkstore.com/healthcare/53012/stem-cell-research-products-opportunities-tools-
and-technologies
Table Of Content
I. ABSTRACT

II. BACKGROUND: TYPES OF STEM CELLS

A. Human Embryonic Stem Cells (hESCs)
1. Early, 5-7 days (totipotent)
2. Gonadal Ridge, 6 months (multipotent)
B. Fetal Stem Cells (pluripotent)
C. Umbilical Cord Stem Cells (multipotent)
1. Cord Blood
2. Cord Matrix (Whartons Jelly)
D. Adult Stem Cells (multipotent)
1. Hematopoietic Stem Cells
2. Mesenchymal Stem Cells
3. Neural Stem Cells
4. Dental Stem Cells (multipotent)
E. Cancer Stem Cells (multipotent)
F. Induced Pluripotent Stem Cells (iPSCs)
G. Novel (recently discovered and uncharacterized) Stem Cell Types
1. Neural Rosette Cells (R-NSCs)
2. Very Small Embryonic Like (VSEL) Stem Cells
H. Stimulus-Triggered Acquisition of Pluipotency (STAP) Cells [Unverified]

III. TIMELINE OF KEY STEM CELL EVENTS

IV. STEM CELL RESEARCH APPLICATIONS


Aarkstore Enterprise




A. Regenerative Medicine (Cell-Based Therapies)
1. Diabetes Mellitus
2. Cardiovascular Disease
3. Neurological Disease
4. Autoimmune Disease
5. Hematopoietic Disease and Transplantation Research
6. Orthopedic Repair
7. Cancer Research
8. Birth Defect Research
B. Drug Development & Discovery
1. Assays to Aid Early Stage Discovery
2. Improved Prediction of Human Responses
3. Drug Development with Humanized Mouse Models
4. Genetically-Engineered Stem Cell Lines for Screening
5. Pluripotent Stem Cell Lines for Target Validation and Drug Screening
6. Summary - Use of Stem Cells in Drug Development & Discovery

V. KEY MARKET COMPETITORS: PROVIDERS OF DIVERSE STEM CELL PRODUCT LINES

A. Thermo Fisher Scientific (Recently Merged with Life Technologies / Includes Invitrogen Brand)
1. Stem Cell Products
a. Isolation and Characterization Products
b. Expansion and Differentiation Products
2. Collaborations
a. Invitrogen and Cellartis AB
b. Invitrogen and Novocell
c. Invitrogen and the Buck Institute
d. Life Technologies and Cellular Dynamics International
e. Life Technologies and iPS Academia Japan
f. Life Technologies and Harvard University
g. Life Technologies and DNAVEC Corporation
B. BD Biosciences
1. Stem Cell Products
a. Isolation
b. Culturing
c. Analysis
2. Collaborations: BD Biosciences and STEMCELL Technologies

VI. PRODUCT AREAS

A. Primary Antibodies
B. Bead-based Cell Separations Systems
C. Fluorescent-based Labeling and Detection
D. Protein Purification and Analysis Tools
1. Protein Purification
2. Stem Cell Protein Analysis
3. Quantitative Proteomics
E. DNA/RNA Based Characterization

Aarkstore Enterprise




1. Tools for DNA- and RNA-based Characterization
2. Stem Cell HLA Typing
3. Stem Cell Nucleic Acid Extraction and Purification, PCR/qRT-PCR Reagents
F. Isolation / Characterization Services
1. Stem Cell HLA Typing Services
2. Stem Cell Custom Services
3. Stem Cell Custom Antibodies
G. Stem Cell Culture Media and Reagents
H. Growth Factors and Cytokines
I. Stem Cell Gene Regulation
J. In vivo / In vitro Stem Cell Tracking
K. Expansion / Differentiation Services
1. Stem Cell Media Services
2. RNAi Services
L. Stem Cell Lines
M. Summary of Product Categories

VII. MARKET SIZE

A. Definition: Stem Cell Research Products
B. Experimental Approach
C. Stem Cell Research Products, Market Size Determination
D. Stem Cell Antibodies, Market Size Determination
E. Stem Cell Therapies, Market Size Determination

VIII. CURRENT MARKET ASSESSMENT

A. Breakdown of Research Segments by End-user Application
1. Basic Research
2. Applied Research
a. Autologous and Allogeneic Cell Therapy
b. Toxicology Screening for Drug Discovery and Development
B. Breakdown of Stem Cell Research by Cell Type
C. Emerging Areas for Stem Cell Products
1. Cord Blood Stem Cells
2. Dental Stem Cells
3. Induced Pluripotent Stem Cells (iPSCs)
D. Top 10 Most Influential People within Stem Cell Industry

IX. MARKET TRENDS ANALYSIS

A. Clinical Trial Data
B. Grant Analysis
C. Patent Analysis
D. Scientific Publication Rate Analysis
1. Historical Data
2. Future 5-Year Projections
3. Comparison of Stem Cell Research Frequency, by Cell Type

Aarkstore Enterprise




E. Sources of Stem Cell Funding
1. Federal
2. State
3. Private

X. MARKET FORECASTS AND FUTURE CONSIDERATIONS

A. 5-Year Market Forecasts
B. Future Considerations
1. Near-term (1-3yrs): Stem Cells as Tools for Drug Discovery
2. Short-term (3-5yrs): Therapies Involving Cord Blood and Adult Stem Cells
3. Long-Term (10yrs): Therapies involving hESCs

XI. SCIENTIST PANEL - DETAILED END-USER SURVEY

A. Survey Overview
B. Characterization of Market Survey Respondents
1. Geographic Distribution of Respondents
2. Respondent Breakdown by Industry Affiliation
3. Breakdown of Respondents by Duration of Stem Cell Research Activity
C. Survey Findings General Scope
D. Survey Findings Applied Stem Cell Research
E. Survey Findings Comparison of Providers (Brand Preferences)

XII. STRATEGIES FOR ACCESSING THE MARKETPLACE

A. Top Research Institutions Performing Stem Cell Research
1. University of Wisconsin, including WARF, WiCell, and the WISC Bank
2. Johns Hopkins University
3. US National Institutes of Health (NIH)
4. California Institute for Regenerative Medicine
B. Events of Interest

XIII. CONCLUSIONS

APPENDICES

APPENDIX A Full List of Conditions Being Explored within Stem Cell Clinical Grants Trials (2014)
APPENDIX B Full List of Stem Cell Conferences (2014)





Aarkstore Enterprise




Related reports:

Stem Cell Research Market in India 2014
Promega Corporation - Medical Equipment - Deals and Alliances Profile
Global Flow Cytometry Market
Cerebral Palsy - Pipeline Review, H2 2014
Epidermolysis Bullosa - Pipeline Review, H2 2014
Global Orthopedic Biomaterials Market 2014-2018
Metastatic Ovarian Cancer - Pipeline Review, H2 2014
Non-Hodgkin Lymphoma Therapeutics in Asia-Pacific Markets to 2020 - Novel Technologies Show
Considerable Promise in Relapsed/Refractory Setting


About Aarkstore Enterprise
Aarkstore Enterprise is a leading provider of business and financial information and solutions worldwide. We
specialize in providing online market business information on market research reports, books, magazines,
conference at competitive prices, and strive to provide excellent and innovative service to our customers.
Contact Details:
Aarkstore Enterprise
Phone: +91 998 729 5242
Email: enquiry@aarkstore.com
Our Website: http://www.aarkstore.com