Generic Name: ketorolac tromethamine

Brand Name: Toradol

Classifications: NSAID ;Non-narcotic analgesic
Mechanism of Action: Anti-inflammatory and analgesic activity; inhibits prostaglandins and leukotriene synthesis.
Indications: Short-term management of pain
Contraindications: Contraindications: significant renal impairment, pregnancy, lactation; patients wearing soft contact lenses
(ophthalmic).Use cautiously with impaired hearing, allergies, hepatic, CV, and GI conditions.
Adverse Drug Reactions: CNS: Headache, dizziness, somnolence, insomnia, fatigue, tiredness, dizziness, tinnitus,
ophthamological effects ; GI: Nausea, dyspepsia, GI pain, diarrhea, vomiting, constipation, flatulence ; Respiratory: Dyspnea,
hemoptysis, pharyngitis, bronchospasm, rhinitis ; Hematologic: Bleeding, platelet inhibition with higher doses, neutropenia,
eosinophilia, leukopenia, pancytopenia, thrombocytopenia, agranulocytosis, granulocytopenia, aplastic anemia, decreased Hgb or
Hct, bone marrow depression, menorrhagia ; GU: Dysuria, renal impairment ;Dermatologic: Rash, pruritus, sweating, dry mucous
membranes, stomatitis ; Other: Peripheral edema, anaphylactoid reactions to fatal anaphylactic shock, local burning, stinging
(ophthalmic)
Dosage: 30mg, 1 dose stat, every 8 hours
Nursing Responsibilities:

Maintain emergency equipment on standby at time of initial dose, in case of severe hypersensitivity reaction.
Protect drug vials from light.
Administer every 6 h to maintain serum levels and control pain.










Generic Name: Ranitidine
Brand Name: Zantac
Classifications: Histamine, Antagonist
Mechanism of Action: Competitively inhibits the action of histamine at the histamine
2
(H
2
) receptors of the parietal cells of the
stomach, inhibiting basal gastric acid secretion and gastric acid secretion that is stimulated by food, insulin, histamine,
cholinergic agonists, gastrin, and pentagastrin.
Indications: Short-term treatment of active duodenal ulcer.Maintenance therapy for duodenal ulcer at reduced dosage
.Short-term treatment of active, benign gastric ulcer. Short-term treatment of gastroesophageal reflux disease. Pathologic
hypersecretory conditions (eg, Zollinger-Ellison syndrome). Treatment of erosive esophagitis. Treatment of heartburn, acid
indigestion, sour stomach
Contraindications: Contraindications: allergy to ranitidine, lactation. Use cautiously with impaired renal or hepatic
function.
Adverse Drug Reactions: CNS: Headache, malaise, dizziness, somnolence, insomnia, vertigo. GI: Constipation,
diarrhea, nausea, vomiting, abdominal pain, hepatitis, increased SGPT levels . CV: Tachycardia, bradycardia, PVCs (rapid
IV administration). Hematologic: Leukopenia, granulocytopenia, thrombocytopenia, pancytopenia. GU: Gynecomastia,
impotence or loss of libido . Dermatologic: Rash, alopecia. Local: Pain at IM site, local burning or itching at IV site . Other:
Arthralgias

Dosage: 50mg IVTT every 8am and 8pm
Nursing Responsibilities: Administer oral drug with meals and at bedtime. Decrease doses in renal and liver failure.
Provide concurrent antacid therapy to relieve pain. Administer IM dose undiluted, deep into large muscle group. Arrange for
regular follow-up, including blood tests, to evaluate effects.