-nitric oxide is the most important mediator of coronary vascular dilation in large arteries ad pre-arteriolar vessels . -Adenosine, a product of ATP metabolism, acts as a vasodilatory element in the small coronary vessels. -acute pericarditis - pain decreases on sitting up and leaning forward -congetnital QT: AR condition, which is accompanied by congenital neurosensory deafness. -pulsus paradoxus is an important clue to cardiac tamponade. it is dened as a decrease in the systolic pressure of 10mmHG or more during inspiration as compare with the pressure during exhalation. -paradoxical thromboembolism occurs when a blood clot from the venous system crosses directly into the arterial circulation via an abnormal connection between the the R and L cardiac chambers, such as ASD or ventricular sepal defect. Ausculatory nding in an ASD includes a wide and xed splitting of S2! -pericarditis is the m commonly cardiovascular syndrome associated with SLE. -VSD: is associated with low-pitched, holosystolic murmur that accentuates during maneuvers that increase after load (handgrip maneuver). \ -VSD )holosystolic murmor over the left sternal border) can cause increase in O2 saturation between the 2 right sided vessels or chambers indicating the presence of a left-to-right shunt. -heart failure due to left ventricular diastolic dysfunction is the result of an decrease in diastolic LV compliance. Amyloidosis( may cause diastolic dysfunction). -A pre systolic sound on cardiac auscultation that immediately precedes S1 is most often an S4 gallop. An S4 requires normal atrial contraction and results from rapid emptying of arterial blood into a ventricle with reduced compliance (stiff ventricle). -during aortic regurgitation, increase in left ventricular preload (LVEDC) is rthe major long-term hemodynamic compensatory response to the volume overload of AR. -ou wont see high systolic pressure gradient between the LV and Aorta in the case of dilated cardiomyopathy. -squatting in tetralogy of fallout helps increase systemic vascular resistance. -mitral regurgitation: holosystolic murmor best heard at the apex and the best indicator of MR is a presence of audible S3 gallop. Brain Natriretic peptide is elevated in patients with heart failure and is often used as a laboratory test inn the clonal setting to determine if a patient is suffering from CHF exacerbation.It acts along with ANP to cause vasodilation (decrease preload) and diuresis. -holosystolic murmur found all over the cardiac apex = mitral regurgitation, -cardiac (pericardial) tamponade presents clinically with hypotension, tachycardia, and an elevated central venous pressure that produces venous distention. -abnormal tachyarrhythmias = shortened PR interal, delta wave at the start of QRS, and widened QRS interval. -wide, xed splitting of the scone heart sound is a characteristic auscultatory nding in patients with ASD. It requires surgical repair to prevent irreversible changes in the pulmonary vessels. -Rheumatic heart disease is avery common cause of MR in underdeveloped countries.