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(a) Streptomycin
(b) Amikacin
(c) Neomycin
(d) Tobramycin
(e) Kanamycin
(a) Ethambutol
(b) Cycloserine
(c) Streptomycin
(d) INH
(e) PAS
The answer is d---- Only actively growing tubercle bacilli are susceptible to
the bactericidal property of INH. The major action of INH is on the cell wall
of the bacillus, where it prevents the synthesis of mycolic acid.
(a) Polymyxin B
(b) Penicillin G
(c) Dicloxacillin
(d) Carbenicillin
(e) Streptomycin
(a) Adenosine
(b) Procainamide
(c) Lidocaine
(d) Nifedipine
(e) Verapamil
The answer is c---- Beta adrenergic receptor blockers cause a slowing of heart
rate, lower blood pressure, and lessened cardiac contractility without
reducing cardiac output. There is also a buffering action against adrenergic
stimulation of the cardiac autoregulatory mechanism. These hemodynamic
actions decrease the requirement of the heart for oxygen.
11- A 59-year old female with mild CHF is treated with furosemide. What
is its primary mechanism of action?
(a) Lovastatin
(b) Probucol
(c) Clofibrate
(d) Gemfibrozil
(e) Nicotinic acid (NA)
13- The EKG of a patient who is receiving digitalis in the therapeutic dose
range would be likely to show
(a) Hydralazine
(b) Minoxidil
(c) Diazoxide
(d) Sodium nitroprusside
(e) Nifedipine
The answer is a------ Lovastatin should not be used in patients with severe
liver disease. With routine use of lovastatin, serum transaminase value may
rise, and in such patients the drug may be continued only with great caution.
Lovastatin has also been associated with lenticular opacities, and slit-lamp
studies should be done before and one year after the start of the therapy.
There is no effect on the otic nerve. The drug is not toxic to the renal system,
and receptors of the bone marrow depression are very rare. There is a small
incidence of myopathy, and levels of creatinine kinase should be measured
when unexplained muscle pain occurs. Combination with cyclosporine or
clofibrate has led to myopathy. There is no danger in use with bile acid
sequestrants.
19- A 70-year old female is treated with sublingual nitroglycerin for her
occasional bouts of angina. Which of the following is involved in the
action of nitroglycerin?
20- A 56-year old female has recently developed essential hypertension, for
which she is receiving chlorothiazide to lower her blood pressure.
Which of these ions would not increase in concentration in her urine?
(a) K+
(b) Cl-
(c) Ca++
(d) Na+
(e) Mg++
21- A 60-year old female with deep vein thrombosis (DVT) is given a bolus
of heparin, and a heparin drip is also started. Thirty minutes later, she
is bleeding profusely from the intravenous site. The heparin is stopped,
but the bleeding continues. You decide to give protamine to reverse
the adverse effect of heparin. How does protamine act?
22- A 47-year old female comes to the emergency department (ED) with
severe crushing chest pain of one hour’s duration. Electrocardiogram
and blood chemistries are consistent with a diagnosis of acute MI.
streptokinase is chosen as part of the therapeutic regimen. What is its
mechanism of action?
23- A 60-year old male with chronic obstructive lung disease is given
ipratropium as part of his therapeutic regimen. What is the mechanism
of action of ipratropium?
(a) Inhibition of airway muscarinic receptor
(b) Inhibition of 5-lipoxygenase
(c) Breakdown of mucus
(d) Inhibition of mediator release
(e) Inhibition of phosphodiesterase
(f) Activation of beta-adrenergic receptor
24- A one-year old male develops breath sounds, and wheezing during a
febrile episode, which is relieved by albuterol. What is the mechanism
of action of albuterol?
26- A 65-year old male post-MI with an elevated LDL level is treated with
atorvastatin. What is the mechanism of action of atorvastatin?
(a) Hydrochlorothiazide
(b) Amiloride
(c) Mannitol
(d) Ethacrynic acid
(e) Spironolactone
The answer is c------ Mannitol increases serum osmolarity and therefore pulls
water out of cells, cerebrospinal fluids (CSF) and aqueous humor. This effect
can be useful in the treatment of elevated intraocular or intracranial
pressure. However, by expanding the intravascular volume, mannitol can
exacerbate CHF.
(a) Acetazolamide
(b) Chlorothiazide
(c) Ethacrynic acid
(d) Chlorthalidone
(e) Spironolactone
30- Conservation of K+ ions in the body occurs with which of the following
diuretics?
(a) Furosemide
(b) Hydrochlorothiazide
(c) Triamterene
(d) Metolazone
(e) Bumetanide
31- Cimetidine slows the metabolism of many drugs because it inhibits the
activity of
32- Omeprazole, an agent for the promotion of healing of peptic ulcers, has
a mechanism of action that is based on
(a) Prostaglandins
(b) Gastric secretion
(c) Pepsin secretion
(d) H+,K+,ATPase
(e) Anticholinergic action
34- Bismuth salts are thought to be effective in peptic ulcer disease because
they have bactericidal properties against