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fm — 11/30/06
Keywords: head and neck imaging, head and neck radiology, parotid gland,
sonography DOI:10.2214/AJR.05.1549 Received September 1, 2005; accepted after
revision December 7, 2005.
1Department
of Radiology, Eastbourne District General Hospital, East Sussex BN21 2UD, United
Kingdom. of Maxillofacial Surgery, Eastbourne District General Hospital, King’s
Dr., Eastbourne, East Sussex BN21 2UD, United Kingdom. Address correspondence to
D. C. Howlett (David.Howlett@ESHT.NHS.UK).
2Department
District General Hospital, Eastbourne, East Sussex, BN21 2UD, United Kingdom. AJR
2007; 188:223–227 0361–803X/07/1881–223 © American Roentgen Ray Society
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Howlett et al.
patient, the benefits and potential hazards of the procedure having been
explained. Contraindications to biopsy included inability to provide written
consent or to cooperate and concurrent use of anticoagulant medication or presence
of known bleeding diathesis. Preprocedural assessment of platelet count and
clotting parameters was not undertaken routinely. All diagnostic sonographic
examinations and biopsies were performed by a single operator using a freehand
biopsy technique. With an aseptic technique and after administration of 1%
lidocaine local anesthetic, a small skin incision was made and a biopsy needle
introduced under sonographic guidance. Biopsy specimens were obtained with a
spring-loaded device. For the first 16 patients a 22-mm fixed-throw mechanism
(Biopty Gun, Bard) was used, and thereafter, a 15- to 22-mm variable throw device
(Magnum gun, Bard). An average of two passes were made per patient. Biopsy samples
were fixed in a jar containing 10% formalin and were sent for histologic analysis.
All parotid lesions were demarcated sonographically as lying in the superficial
lobe of the gland and had a size range of 6–58 mm. In most (n = 122) of the
patients, 18-gauge needles were used. Because of the hazards of facial nerve and
vascular injury, 20-gauge needles were used in patients (n = 13) with smaller
lesions situated close to the main intraparotid vessels. Under sonographic
guidance, lesions were approached along the longitudinal, oblique, or transverse
plane, depending on the position of the lesion and to avoid adjacent structures
(Fig. 1). Biopsy specimens of cystic lesions were obtained from the cyst wall,
samples being directed at the more solid components of lesions of mixed cystic and
solid appearance. The needle throw of the variable-throw biopsy device was
selected according to the size and situation of the lesion to allow adequate
lesion sampling but to ensure the needle did not exit deep in relation to the
lesion (Fig. 2). Most of the biopsy procedures took less than 15 minutes. After
biopsy, patients were asked to compress the puncture site and were observed for 30
minutes before discharge. Final diagnosis was established on the basis of adequate
histologic findings in the core biopsy specimen and surgical histologic findings
for the surgical group or clinical follow-up findings for patients who did not
undergo surgery. The follow-up period ranged from a few months to 7 years.
Fig. 1—32-year-old woman with normal parotid gland. Longitudinal sonogram shows
main intraparotid vessels. Retromandibular vein (large arrow) is superficial to
external carotid artery (small arrow). Facial nerve is not shown but passes just
superficial to retromandibular vein. Deep parotid lobe (D) is deep in relation to
plane passing through path of nerve, and superficial lobe (S) is superficial to
this plane.
volved 16 [9], 54 [10], and 53 [11] patients with parotid swelling and showed a
diagnostic accuracy of 97% [10, 11] to 100% [9] for sonographically guided core
biopsy findings compared with surgical histologic findings, and there were no
significant complications. In two of the studies [9, 10], 18-gauge or smaller
needles were used with a mean of two passes per patient. In the third study [11],
small- and largebore needles (up to 14-gauge) and a range of needle passes were
used. The purpose of our study was to evaluate the accuracy and safety of
sonographically guided core biopsy performed only with small-bore needles in a
series of 135 patients presenting with a parotid mass. Subjects and Methods
Over the 7-year period from 1998 to 2004, 135 patients consecutively referred for
evaluation of a parotid mass were incorporated into this prospective study. Sixty-
three patients were men, and 72 were women. The age range was 18–93 years (mean,
60 years). After initial diagnostic sonographic examination (ATL HDI 5000 system,
Philips Medical Systems) with a high-resolution linear array transducer (12–5 MHz;
7–4 MHz in larger patients or for deeper lesions), the operator proceeded to core
biopsy. Before biopsy, written consent was obtained from the
Results Of the 135 patients in the study, 76 underwent surgery and 59 avoided
surgery. Initial sonograms showed a focal lesion suitable for biopsy in 124
patients; 11 patients in the nonsurgical group had diffuse sonographic
abnormalities with no discrete focal lesion. All sonographically guided core
biopsy specimens were considered satisfactory for evaluation by the
histopathologist. In the surgical group, 55 patients had a diagnosis of benign
neoplasm (37, pleomorphic adenoma [Fig. 3]; 16, Warthin’s tumor [Fig. 4]; two,
oncocytoma). Eighteen patients had a diagnosis of malignancy (three,
mucoepidermoid carcinoma [Fig. 5]; one, adenoid cystic carci-
Fig. 2—68-year-old woman with painless, progressive parotid gland enlargement and
Sjögren’s syndrome. Biopsy findings confirmed diagnosis of non-Hodgkin’s lymphoma
complicating Sjögren’s syndrome. A and B, Sonograms show 16-mm pseudocystic mass
in tail of right parotid gland. Tip of biopsy needle (arrow, A) is positioned so
that on needle discharge with 15-mm setting of biopsy device, needle traverses but
does not exit lesion. Confirmation of needle placement is seen in B.
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Fig. 3—48-year-old man with painless parotid mass. Sonogram of pleomorphic adenoma
shows rounded and circumscribed hypoechoic solid mass in superficial lobe of
parotid. Distal acoustic enhancement is evident.
Fig. 5—67-year-old woman with painless, rapidly enlarging parotid mass. Sonogram
of mucoepidermoid carcinoma shows ill-defined, hypoechoic mass in superficial lobe
of parotid gland. Lesion is of heterogeneous echotexture, and distal acoustic
shadowing is present. Sonographic features are those of primary malignant tumor of
parotid, although histologic subtypes cannot be differentiated with sonography.
noma; two, adenocarcinoma; one, oncocytic carcinoma; two, squamous cell carcinoma;
two, poorly differentiated carcinoma; one, melanoma; six, non-Hodgkin’s lymphoma).
Three patients had miscellaneous, nonneoplastic diagnoses (one, lymphadenitis; one
lymphoepithelial cyst; one, actinomycosis). In the nonsurgical group, 16 patients
had a diagnosis of benign neoplasm (eight, pleomorphic adenoma; eight, Warthin’s
tumor), and 17
had a diagnosis of malignant neoplasm (one, adenocarcinoma; one, small cell lung
carcinoma; one, nasopharyngeal carcinoma; three, squamous cell carcinoma; 11, non-
Hodgkin’s lymphoma). Fifteen patients had a nonneoplastic diagnosis and a focal
lesion present at sonography (eight, reactive nodal hyperplasia; three,
tuberculosis; one, sarcoidosis; one, retention cyst; two, sclerosing
sialadenitis). Eleven patients had a nonneoplastic diagnosis
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16.
17.
References
1. McGuirt WF, McCable BF. Significance of node biopsy before definitive treatment
of cervical metastatic carcinoma. Laryngoscope 1978; 88:594–597 2. Eneroth CM,
Franzen S, Zajicek J. Cytologic diagnosis on aspirate from 1000 salivary gland
tumors. Acta Otolaryngol 1967; 1:168–171 3. Coghill S, Brown L Why pathologists
should take needle aspiration specimens. Cytopathology 1991; 2:67–74 4. Filipoulos
E, Angeli S, Daskalopoulou D, Kelessis N, Vassilopoulos P. Preoperative evaluation
of parotid tumors by fine needle biopsy. Eur J Surg Onocol 1998; 24:180–183 5.
Zbären P, Schär C, Hotz MA, Loosli H. Value of fine needle aspiration cytology of
parotid gland masses. Laryngoscope 2001; 111:1989–1992 6. Cohen E G, Patel S G,
Lin O, et al. Fine needle aspiration biopsy of salivary gland lesions in a
selected patient population. Arch Otolaryngol Head Neck Surg 2004; 130:773–778
18. 19.
20.
21.
22.
23.
24.
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