Fall Session Year 3

APM384 - Partial Differential Equations

Boundary value problems and Sturm-Liouville theory for ordinary differential equations.
Partial differential equations of first order, characteristics,Hamilton-Jacobi theory.
Diffusion equations; Laplace transform methods. Harmonic functions, Greens functions
for Laplaces equation, surface and volume distributions; Fourier transforms. Wave
equation, characteristics; Greens functions for the wave equation; Huygens principle.
BME344 - Modeling, Dynamics, and Control of Biological Systems
Introduction to modeling of physiological control systems present in the human body,
combining physiology, linear system modeling and linear control theory. Topics include:
representation of physical systems using differential equations and linearization of these
dynamic models; graphical representation of the control systems/plants; Laplace
transforms; transfer functions; performance of dynamic systems; time and frequency
analysis; observability and controllability; and close-loop controller design.

BME350 - Biomedical Systems Engineering I: Organ Systems
An introduction to human anatomy, physiology, and physiological control systems, with
focus on the cardiovascular, respiratory, nervous, renal, gastrointestinal, musculoskeletal,
and endocrine systems. Structures and mechanisms responsible for the function and
control of these complex systems in the healthy and diseased human body. Application of
clinical and biomedical engineering tools to model homeostasis and perturbations to
normal function.

BME395 - Biomedical Systems Engineering II: Cells and Tissues
This course focuses on the molecular biology of cells, building on BME105, and their
integration into tissues and organs. It covers integrating cells into tissues; molecular
genetic techniques; signalling at the cell surface and signalling pathways that control
gene activity; integration of signals and gene controls, the eukaryotic cell cycle, cell birth,
lineage and death; inflammation, wound healing and immunology. The course will be
centered around the problems of tissue engineering and of other medical devices or
therapeutic options. There will be considerable emphasis on learning to read the research
literature.

CHE391 - Organic Chemistry and Biochemistry
This course examines the sources, structures, properties and reactions of organic
chemicals with reference to their interactions with the environment. Industrial organic
chemistry, biochemical compounds and relevant biochemical reactions will be discussed.

ESC301 - Engineering Science Option Seminar
The Option seminar supports option-related curriculum through discussion of ethics,
philosophy and research in a seminar-based setting. Guest speakers, presentations and
other special activities will highlight various topics of interest, including the present and
future research related to the Option. This course will be offered on a pass/fail basis and
the assessment will be based on active discussion within the seminar.
Winter Session Year 3

BME346 - Biomedical Engineering and Omics Technologies
An introduction to the principles and design of fundamental technologies used in
biomedical engineering and omics research. Topics may include but are not limited to
tissue culture; spectroscopy; electrophoresis; PCR, genomics, sequencing technologies,
and gene expression measurement; protein expression assays and tagging strategies;
fluorescence labeling tools, microscopy, and high content imaging; DNA manipulation
and transfection, RNAi, and other genetic and molecular tools for transformation of
organisms. Laboratories will provide hands-on experience with selected technologies.
Students will engage in a major design project in which they will design an experimental
plan to investigate a specific research question, also of their design, utilizing available
laboratory technologies.

BME358 - Molecular Biophysics
Topics to be covered will include: review of basic protein structure; molecular forces;
thermodynamics of living systems: protein folding, physics of many-particle systems;
open systems and chemical thermodynamics: Gibbs free energy and chemical potential;
bioenergetics and molecular motors; electrical properties of living cells: Poisson-
Boltzmann, membrane potential, cardiac cell and other excitable cells; chemical kinetics
and reactions; mechanical properties of biomolecules; molecular manipulation
techniques.

BME396 - Biomedical Systems Engineering III: Molecules and Cells
A quantitative approach to understanding cellular behaviour. Using engineering tools
(especially derived from transport phenomena and chemical kinetics) to integrate and
enhance what is known about mammalian cell behaviour at the molecular level. Specific
topics include: receptor-ligand interactions, cell adhesion and migration, signal
transduction, cell growth and differentiation. Examples from gene therapy, and cellular
and tissue engineering are used.

MIE439 - Biomechanics I
Introduction to the application of the principles of mechanical engineering - principally
solid mechanics, fluid mechanics, and dynamics - to living systems. Topics include
cellular mechanics, blood rheology, circulatory mechanics, respiratory mechanics,
skeletal mechanics, and locomotion. Applications of these topics to biomimetic and
biomechanical design are emphasized through a major, integrative group project.

MSE352 - Biomaterials and Biocompatibility
The course presents an introduction to the field of biomaterials, covering also the relevant
basics in materials science and biology. Topics include the physical and chemical
principles of materials science, structure-property relations, biomaterials processing and
degradation. Cell/tissue biomaterials interactions will be discussed as determinants of
biocompatibility.

ESC301 - Engineering Science Option Seminar
Fall Session Year 4

ESC499 Thesis
Every student in Fourth Year Engineering Science is required to prepare a thesis on an
approved subject. Instructions concerning the thesis requirements are issued during the
Winter Session of Third Year and copies may be obtained in the Division office. The
weight allocated to the thesis in each option is shown in the Fourth Year curriculum. Full
year theses are graded after submission in the Winter Session and the grade included in
the weighted average for that session only.

BME428 - Biomedical Systems Engineering IV: Computational Systems Biology
The objective of this course is to introduce students to current computational methods in
molecular biology and dynamic modeling that are used to analyze biological systems
with quantitative reasoning. By the end of the course, the student should be able to:
describe current methods in computational molecular biology; employ quantitative
reasoning to analyze biological systems; analyze large biological datasets using machine
learning and statistical methods; apply motif and evolutionary models to genome
sequencing; analyze cell signaling networks by systems modeling approaches.

BME479 - Introduction to Biomedical Systems Engineering Design Concepts
A seminar to introduce students to concepts in biomedical systems engineering design in
preparation for BME489H1 - Biomedical Systems Engineering Design. Review of
general design concepts in the context of biodesign practice. Discussion of issues related
to biodesign, including regulatory processes, intellectual property, and global health.
Students will be introduced to clients, identify a design project, and define their design
problem. At the end of the term, students will deliver a draft "elevator pitch" for their
project.

CHE374 - Economic Analysis and Decision Making
Economic evaluation and justification of engineering projects and investment proposals.
Cost estimation; financial and cost accounting; depreciation; inflation; equity, bond and
loan financing; after tax cash flow; measures of economic merit in the private and public
sectors; sensitivity and risk analysis; single and multi-attribute decisions. Introduction to
micro-economic. Applications: retirement and replacement analysis; make-buy and buy-
lease decisions; economic life of assets; capital budgeting; selection from alternative
engineering proposals; production planning; investment selection.

Complementary Studies elective

Technical elective






Winter Session Year 4

ESC499 Thesis
Every student in Fourth Year Engineering Science is required to prepare a thesis on an
approved subject. Instructions concerning the thesis requirements are issued during the
Winter Session of Third Year and copies may be obtained in the Division office. The
weight allocated to the thesis in each option is shown in the Fourth Year curriculum. Full
year theses are graded after submission in the Winter Session and the grade included in
the weighted average for that session only.

BME489 - Biomedical Systems Engineering Design
A capstone design project that provides students in the Biomedical Systems Engineering
option with an opportunity to integrate and apply their technical knowledge and
communication skills to solve real-world biomedical engineering design challenges.
Students will work in small groups on projects that evolve from clinical partners,
biomedical/clinical research and teaching labs, and commercial partners. At the end of
the course, students submit a final design report and a poster for public exhibition.

Complementary Studies elective

Technical elective

Technical elective