1

kLGIS1kA1ICN ASSLSSMLN1 SAMLL ALk 2013

1


Ak1 1WC - CLN 8CCk and CALCULA1ICNS



Instruct|ons to cand|dates:

1. lor each quesLlon Lhere are flve opLlons A, 8, C, D and L. Choose only one of Lhe
opLlons as your answer for each quesLlon.
2. ?ou should answer Lhe quesLlons as Lhough you were a reglsLered pharmaclsL, not a
pre-reglsLraLlon Lralnee.
3. unless oLherwlse sLaLed you should answer all quesLlons as Lhough a pandemlc
slLuaLlon has not arlsen and ls not anLlclpaLed.
4. 1here are 30 open book quesLlons ln Lhls paper and 10 calculaLlon quesLlons. 1he
Llme allowance for Lhls paper ls 73 mlnuLes.
|ease note: 1hls ls half Lhe number of quesLlons ln Lhe acLual reglsLraLlon
assessmenL open book paper, and half Lhe Llme allowed for Lhe acLual paper.
3. ?ou should score one mark for each correcL answer, no marks should be deducLed for
lncorrecL answers or omlsslons.
6. 1he reference sources LhaL may be used ln Lhls paper are 8rlLlsh naLlonal lormulary
number 64 (SepLember 2012 edlLlon) and 8rlLlsh naLlonal lormulary for Chlldren
2012-13. lease noLe LhaL some of Lhe quesLlons wlll requlre use of Lhese references,
oLhers wlll noL.
7. ?ou are noL permlLLed Lo use a calculaLor ln any parL of Lhe assessmenL.
8. lf represenLaLlons of prescrlpLlons are lncluded ln quesLlons you may presume LhaL
the prescription is genuine and the prescribers signature is known to you.



"
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/1&(%$61.#.077 8+% &,-./% .,.%0 (& -,'9+%2 ') '+% ,9'$,/ ,&&%&&-%*' (* '%0-& )4
2(44(9$/'6: &6//,;$& 9)1%0,<% ,*2 0,'() )4 =$%&'()* '6.%&7

CopyrlghL Ceneral harmaceuLlcal Councll 2013.
1he conLenL of Lhls documenL ls Lhe properLy of Lhe Ceneral harmaceuLlcal Councll
and may noL be reproduced.


2
SLC1ICN I
(10 quest|ons)

D|rect|ons for quest|ons 1 to 10. Lach of Lhe quesLlons or lncompleLe sLaLemenLs ln Lhls
secLlon ls followed by flve suggesLed answers. SelecL Lhe besL answer ln each case.

1. WhllsL Laklng warfarln LableLs paLlenLs should be advlsed Lo avold drlnklng
whlch one of Lhe followlng [ulces?
A cranberry

8 orange

C grapefrulL

D LomaLo

L apple


2. ?ou are asked Lo prepare 200 mL of Chloral Lllxlr, aedlaLrlc, 8 2000. WhaL
welghL of chloral hydraLe ls requlred?

A 2 g

8 8 g

C 12 g

D 20 g

L 80 g



3

3. Mrs 8 ls Lermlnally lll, and ls prescrlbed dlamorphlne and cycllzlne Lo be
glven as a conLlnuous subcuLaneous lnfuslon vla a syrlnge drlver. ?ou are
asked Lo recommend a sLable lnfuslon. Whlch one of Lhe followlng would lL
be approprlaLe for you Lo recommend?

A dlamorphlne 30 mg/mL plus cycllzlne 10 mg/mL ln 0.9 w/v sodlum
chlorlde

8 dlamorphlne 30 mg/mL plus cycllzlne 12 mg/mL ln 0.9 w/v sodlum
chlorlde

C dlamorphlne 30 mg/mL plus cycllzlne 10 mg/mL ln waLer for ln[ecLlons

D dlamorphlne 30 mg/mL plus cycllzlne 12 mg/mL ln waLer for ln[ecLlons

L dlamorphlne 30 mg/mL plus cycllzlne 12 mg/mL ln waLer for ln[ecLlons


4. ?ou see Mr A ln your warfarln cllnlc. Pls ln8 ls 7.3, and he reporLs no
bleedlng. Pe drank more alcohol Lhan usual Lwo days before hls cllnlc vlslL.

1he mosL approprlaLe acLlon Lo Lake would be:

A no acLlon, see hlm agaln ln a week

8 advlse hlm Lo omlL hls nexL Lwo doses of warfarln and see hlm agaln ln
Lwo days

C refer hlm urgenLly Lo hls C for furLher lnvesLlgaLlon

D glve hlm 3mg of phyLomenadlone orally

L arrange hosplLal admlsslon, advlse LhaL he recelves phyLomenadlone
3mg lv











4
S. Whlch one of Lhe followlng paLlenLs, who do not have dlabeLes melllLus, has
a 20-30 rlsk of cardlovascular dlsease over Lhe nexL 10 years?

A a 43-year-old male paLlenL who smokes, has a sysLollc blood pressure
of 120 mmPg and a serum LoLal cholesLerol Lo PuL cholesLerol raLlo
of 3

8 a 43-year-old male paLlenL who does not smoke, has a sysLollc blood
pressure of 160 mmPg and a serum LoLal cholesLerol Lo PuL
cholesLerol raLlo of 3

C a 33-year-old male paLlenL who smokes, has a sysLollc blood pressure
of 160 mmPg and a serum LoLal cholesLerol Lo PuL cholesLerol raLlo
of 6

D a 33-year-old male paLlenL who does not smoke, has a sysLollc blood
pressure of 130 mmPg and a serum LoLal cholesLerol Lo PuL
cholesLerol raLlo of 7

L a 63-year-old male paLlenL who smokes, has a sysLollc blood pressure
of 130 mmPg and a serum LoLal cholesLerol Lo PuL cholesLerol raLlo
of 6




3
uest|ons 6 and 7 concern !ohn who ls an 11-year-old chlld wlLh chronlc asLhma, he ls
currenLly uslng Lhe followlng prescrlbed medlcaLlon:

salbuLamol 100 mlcrograms lnhaler 1 or 2 puffs when requlred
SerevenL Lvohaler 23 mlcrograms lnhaler 2 puffs Lwlce a day
Cvar 100 mlcrograms lnhaler 1 puff Lwlce a day

6. Accordlng Lo Lhe 8rlLlsh 1horaclc SocleLy (81S), !ohn ls currenLly aL whlch sLep
of Lhe 81S guldellnes?

A SLep 1

8 SLep 2

C SLep 3

D SLep 4

L SLep 3



7. Johns asthma is currently well controlled, his peak flow readings are within
Lhe expecLed range for hls age and he has not requlred hls salbuLamol lnhaler
for Lhe lasL 4 monLhs. !ohn ls due Lo vlslL hls C for a revlew. WhaL would be
Lhe mosL approprlaLe action to take with regards to Johns treatment regimen,
accordlng Lo Lhe 81S guldellnes?

A Lhe currenL medlcaLlon should be conLlnued aL Lhe prescrlbed doses,
wlLh furLher revlews every Lhree monLhs

8 Lhe dose of Lhe Cvar lnhaler should be reduced by up Lo 30, wlLh
furLher revlews every Lhree monLhs

C Lhe dose of Lhe SerevenL lnhaler should be reduced by up Lo 30, wlLh
furLher revlews every Lhree monLhs

D Lhe dose of boLh Lhe Cvar and SerevenL lnhalers should be reduced by
up Lo 30, wlLh furLher revlews every Lhree monLhs

L Lhe salbuLamol lnhaler should be sLopped, as lL ls no longer requlred




6
8. Mr A, a 76-year-old man, presenLs on your admlsslons ward wlLh acuLe kldney
ln[ury. Pls medlcaLlon hlsLory ls:

slmvasLaLln 20 mg 1 aL nlghL (sLarLed 2 years ago)
aLenolol 30 mg 1 dally (sLarLed 1 year ago)
amlodlplne 3 mg 1 dally (sLarLed 6 monLhs ago)
paraceLamol 300 mg 2 four Llmes a day (C1C, sLarLed 1 week ago)
lbuprofen 400mg 1 Lhree Llmes a day (C1C, sLarLed 1 week ago)

1he medlcaLlon mosL llkely Lo be responslble for Lhe acuLe kldney ln[ury ls:

A slmvasLaLln

8 aLenolol

C amlodlplne

D paraceLamol

L lbuprofen


9. A woman asks for your advlce on Lhe use of a fluorlde supplemenL for her
4-year-old son. 1he fluorlde conLenL of Lhe local waLer supply ls
300 mlcrograms per llLre. Whlch one of Lhe followlng dally doses of fluorlde
lon would be mosL approprlaLe for you Lo recommend?

A 30 mlcrograms

8 123 mlcrograms

C 230 mlcrograms

D 300 mlcrograms

L 1000 mlcrograms



7

10. Mr L has been Laklng rladel LableLs (llLhlum carbonaLe) for a number of years
for blpolar dlsorder. Serum llLhlum levels are monlLored every Lhree monLhs
and are sLable. Mr L has suffered a myocardlal lnfarcLlon and followlng
dlscharge from hosplLal presenLs ln your pharmacy wlLh a prescrlpLlon for Lhe
medlclnes llsLed below. Whlch of Lhe medlclnes llsLed requlre Mr L Lo undergo
addlLlonal llLhlum level monlLorlng?

A slmvasLaLln

8 blsoprolol

C clopldogrel

D ramlprll

L lsosorblde mononlLraLe











8
SLC1ICN II
(6 quest|ons)

D|rect|ons for quest|ons 11 to 13. lor each numbered quesLlon selecL from Lhe llsL above lL
Lhe one leLLered opLlon whlch ls mosL closely relaLed Lo lL. WlLhln each group of quesLlons
each leLLered opLlon may be used once, more Lhan once, or noL aL all.

uest|ons 11 to 13 concern Lhe followlng

A amlsulprlde

8 chlorpromazlne

C clozaplne

D perlcyazlne

L perphenazlne

SelecL from A Lo L whlch one of Lhe above ls:

11. mosL llkely Lo cause myocardlLls

12. llkely Lo cause Lhe mosL pronounced exLrapyramldal slde-effecLs

13. mosL llkely Lo cause conLacL senslLlsaLlon










9
uest|ons 14 to 16 concern Lhe followlng analgeslcs:

A Lramadol

8 celecoxlb

C paraceLamol

D morphlne

L dlclofenac

SelecL, from A Lo L, whlch one of Lhe above:

14. ls a selecLlve cyclo-oxygenase-2 (CCx-2) lnhlblLor

1S. can cause severe hepaLocellular necrosls when Laken ln excess of Lhe
recommended dosage

16. produces analgesla by an oplold effecL and enhancemenL of seroLonln and
adrenerglc paLhways









10
SLC1ICN III
(8 quest|ons)

D|rect|ons for quest|ons 17 to 24. Lach of Lhe quesLlons or lncompleLe sLaLemenLs ln Lhls
secLlon ls followed by Lhree responses. lor each quesLlon CNL or MCkL of Lhe responses
ls/are correcL. ueclde whlch of Lhe responses ls/are correcL. 1hen choose:

A lf 1, 2 and 3 are correcL

8 lf 1 and 2 only are correcL

C lf 2 and 3 only are correcL

D lf 1 only ls correcL

L lf 3 only ls correcL

D|rect|ons Summar|sed
A
1, 2, 3
8
1, 2
only
C
2, 3
only
D
1
only
L
3
only

17. A woman vlslLs your pharmacy Lo ask you Lo recommend someLhlng LhaL she
can buy for her 10-year-old daughLer Lo LreaL head llce. 1he chlld has asLhma
buL ls oLherwlse well. Whlch of Lhe followlng producLs would lL be approprlaLe
for you Lo recommend?

1 uerbac-M llquld (malaLhlon 0.3)

2 Pedrln loLlon (dlmeLlcone)

3 Lyclear Creme 8lnse (permeLhrln)














11
D|rect|ons Summar|sed
A
1, 2, 3
8
1, 2
only
C
2, 3
only
D
1
only
L
3
only

18. 8egardlng SLandard CperaLlng rocedures (SCs), whlch of Lhe followlng
sLaLemenLs ls/are Lrue?

1 lL ls a requlremenL LhaL all pharmacles have wrlLLen SCs for
malnLalnlng a record of Schedule 2 ConLrolled urugs reLurned by
paLlenLs

2 SCs speclfy whaL should be done and by whom

3 SCs conLrlbuLe Lo Lhe cllnlcal governance process


19. Whlch of Lhe followlng medlclnes should be avolded ln a paLlenL wlLh llver
dlsease?

1 plperazlne

2 plzoLlfen

3 propranolol





















12

D|rect|ons Summar|sed
A
1, 2, 3
8
1, 2
only
C
2, 3
only
D
1
only
L
3
only

20. 8egardlng Lhe exLemporaneous preparaLlon of producLs whlch of Lhe
followlng ls/are Lrue?

1 a producL should be dlspensed exLemporaneously only when Lhere ls
no producL wlLh a markeLlng auLhorlsaLlon avallable

2 ln a reglsLered pharmacy, preparaLlon of exLemporaneous producLs
musL be covered ln Lhe pharmacy procedures as seL ouL ln Lhe
Medlclnes (harmacles) (8esponslble harmaclsL) 8egulaLlons 2008

3 exLemporaneously prepared medlclnes are unllcensed


21. Whlch of Lhe followlng sLaLemenLs abouL prescrlpLlons for peLhldlne LableLs
wrlLLen by a denLlsL ls/are correcL?

1 a denLlsL ls legally permlLLed Lo prescrlbe a maxlmum of 3 days supply
of peLhldlne LableLs

2 peLhldlne LableLs may not be prescrlbed by a denLlsL on an nPS
prescrlpLlon

3 the words for dental treatment only must be written on a dental
prescrlpLlon for peLhldlne















13
D|rect|ons Summar|sed
A
1, 2, 3
8
1, 2
only
C
2, 3
only
D
1
only
L
3
only

22. 8egardlng Lhe managemenL of hyperLhyroldlsm, whlch of Lhe followlng
sLaLemenLs ls/are Lrue?

1 carblmazole ls conLralndlcaLed ln moLhers who are breasL-feedlng

2 Lhe dose of carblmazole should be lncreased ln pregnancy

3 propylLhlouracll ls preferred Lo carblmazole durlng Lhe flrsL LrlmesLer of
pregnancy


23. Whlch of Lhe followlng ls a slgn/are slgns of Lheophylllne LoxlclLy?

1 vomlLlng

2 dllaLed puplls

3 hyperglycaemla


24. ?ou have arranged for an lnspecLor from Lhe ChC Lo wlLness Lhe
desLrucLlon of your ouL-of-daLe ConLrolled urugs. Whlch of Lhe followlng
sLaLemenLs regardlng Lhe desLrucLlon of ConLrolled urugs ls/are Lrue?

1 an approprlaLe amounL of caL llLLer or slmllar producL can be used Lo
absorb llquld dose formulaLlons

2 solld dose formulaLlons can be crushed and placed lnLo a small
amounL of hoL, soapy waLer

3 aerosol formulaLlons should be puncLured and Lhe llquld poured lnLo a
ConLrolled urug denaLurlng klL






14
SLC1ICN IV
(6 quest|ons)

D|rect|ons for quest|ons 2S to 30. 1he followlng quesLlons conslsL of a flrsL sLaLemenL ln Lhe
lefL-hand column followed by a second sLaLemenL ln Lhe rlghL-hand column.

ueclde wheLher Lhe f|rst sLaLemenL ls Lrue or false.

ueclde wheLher Lhe second sLaLemenL ls Lrue or false.

1hen choose:

A lf boLh sLaLemenLs are Lrue and Lhe second sLaLemenL ls a correct exp|anat|on
of Lhe flrsL sLaLemenL

8 lf boLh sLaLemenLs are Lrue buL Lhe second sLaLemenL ls NC1 a correct
exp|anat|on of Lhe flrsL sLaLemenL

C lf Lhe flrsL sLaLemenL ls Lrue buL Lhe second sLaLemenL ls false

D lf Lhe flrsL sLaLemenL ls false buL Lhe second sLaLemenL ls Lrue

L lf boLh sLaLemenLs are false




I|rst
Statement

Second
Statement
D|rect|ons Summar|sed

A
8
C
D
L
1rue
1rue
1rue
lalse
lalse
1rue
1rue
lalse
1rue
lalse
2nd sLaLemenL ls a correct exp|anat|on of Lhe flrsL
2nd sLaLemenL ls NC1 a correct exp|anat|on of Lhe flrsL




13



I|rst
Statement

Second
Statement
D|rect|ons Summar|sed

A
8
C
D
L
1rue
1rue
1rue
lalse
lalse
1rue
1rue
lalse
1rue
lalse
2nd sLaLemenL ls a correct exp|anat|on of Lhe flrsL
2nd sLaLemenL ls NC1 a correct exp|anat|on of Lhe flrsL

uest|ons 2S concerns Lhe followlng scenarlo:

Mrs L has sLrepLococcal endocardlLls and has been prescrlbed genLamlcln 80 mg
bd. A one-hour (peak) serum genLamlcln level ls Laken and found Lo be 4 mg/llLre.

2S.
IIkS1 S1A1LMLN1 SLCCND S1A1LMLN1

Mrs Es dose of gentamicin should be
lncreased

1he one-hour (peak) serum
concenLraLlon for genLamlcln for Lhe
LreaLmenL of sLrepLococcal
endocardlLls should be 3 10 mg/llLre


26.
IIkS1 S1A1LMLN1 SLCCND S1A1LMLN1

When lL ls necessary Lo admlnlsLer
Lwo dlfferenL eye-drop preparaLlons
aL Lhe same Llme of day Lhe paLlenL
should be advlsed Lo leave an lnLerval
of aL leasL 3 mlnuLes beLween Lhe Lwo

uralnage of excess eye drop
preparaLlons down Lhe Lear ducLs can
resulL ln lncreased sysLemlc slde-
effecLs of Lhe medlclne

uest|on 27 concerns Lhe followlng scenarlo:

Mr M has been admlLLed Lo hosplLal havlng suffered an S1-segmenL elevaLlon
myocardlal lnfarcLlon and Lhere ls evldence of lefL venLrlcular dysfuncLlon

27.
IIkS1 S1A1LMLN1 SLCCND S1A1LMLN1

Mr M should be prescrlbed an ACL
lnhlblLor prlor Lo dlscharge
8eLa-blockers are conLralndlcaLed ln
paLlenLs wlLh lefL venLrlcular
dysfuncLlon




16







I|rst
Statement

Second
Statement
D|rect|ons Summar|sed

A
8
C
D
L
1rue
1rue
1rue
lalse
lalse
1rue
1rue
lalse
1rue
lalse
2nd sLaLemenL ls a correct exp|anat|on of Lhe flrsL
2nd sLaLemenL ls NC1 a correct exp|anat|on of Lhe flrsL

uest|on 28 concerns Lhe followlng scenarlo:

Mrs C has recenLly been dlagnosed wlLh chronlc lymphocyLlc leukaemla

28.
IIkS1 S1A1LMLN1 SLCCND S1A1LMLN1

lludarablne phosphaLe should be used
as a flrsL llne monoLherapeuLlc
LreaLmenL
nlCL recommends LhaL bendamusLlne
musL never be used as a flrsL llne
Lherapy

uest|on 29 concerns Lhe followlng scenarlo:

Mr 1 ls on hollday ln Lhe uk and presenLs aL your pharmacy wlLh a prescrlpLlon for
Lemazepam LableLs, lssued by hls docLor reglsLered ln Spaln (LLA counLry). ?ou are
able Lo undersLand Lhe prescrlpLlon and are saLlsfled lL ls compleLe.

29.
IIkS1 S1A1LMLN1 SLCCND S1A1LMLN1

A legal supply can be made agalnsL Lhe
prescrlpLlon
rescrlpLlons lssued by a docLor
reglsLered ln an LLA counLry are valld
ln Lhe uk ln cerLaln clrcumsLances












17




I|rst
Statement

Second
Statement
D|rect|ons Summar|sed

A
8
C
D
L
1rue
1rue
1rue
lalse
lalse
1rue
1rue
lalse
1rue
lalse
2nd sLaLemenL ls a correct exp|anat|on of Lhe flrsL
2nd sLaLemenL ls NC1 a correct exp|anat|on of Lhe flrsL

uest|on 30 concerns Lhe followlng scenarlo:

A pharmaclsL colleague aL your place of work ls currenLly under lnvesLlgaLlon by Lhe
Ceneral harmaceuLlcal Councll (ChC) llLness Lo racLlse CommlLLee and you
have been asked Lo glve evldence.

IIkS1 S1A1LMLN1 SLCCND S1A1LMLN1

lL would be approprlaLe for you Lo
refuse Lo dlsclose lnformaLlon abouL
your colleagues fitness to practise
lL ls a requlremenL of Lhe sLandards
produced by Lhe ChC LhaL
pharmaclsLs musL respecL and proLecL
Lhe dlgnlLy and prlvacy of oLhers




Turn over for the designated calculation
questions



18
DLSIGNA1LD CALCULA1ICN ULS1ICNS S1Ak1 nLkL

Some of these quest|ons w||| requ|re use of the reference sources, others w||| not.

D|rect|ons for quest|ons 31(Ca|c) to 38(Ca|c). Lach of Lhe quesLlons or lncompleLe
sLaLemenLs ln Lhls secLlon ls followed by flve suggesLed answers. SelecL Lhe besL
answer ln each case.

31(Ca|c). Mrs 8 presenLs you wlLh a prescrlpLlon for warfarln LableLs 1 mg. 1he
dlrecLlons are Lo Lake 6 mg aL 6pm LhaL evenlng, followed by
alLernaLlng dally doses of 4 mg and Lhen 3 mg (as long as her ln8
remalns wlLhln Lhe recommended range). WhaL ls Lhe exacL number
of warfarln 1 mg LableLs requlred for a 28 day supply assumlng her
ln8 remalns ln range?

A 96

8 98

C 100

D 101

L 111

?ou may use Lhls space for your rough worklng.






















19
32(Ca|c). lf 130 mL ls removed from a bag whlch conLalns 300 mL of glucose
3 and replaced wlLh 130 mL of glucose 20, whlch one of Lhe
followlng ls Lhe sLrengLh of Lhe resulLlng glucose soluLlon?

A 7.3

8 8

C 8.3

D 9

L 9.3

?ou may use Lhls space for your rough worklng.































20
33(Ca|c). An 11-year-old chlld who welghs 33 kg ls Lravelllng Lo 8angladesh
(ChlLLagong Plll 1racLs) for a 21-day hollday and has been prescrlbed
Malarone aedlaLrlc LableLs sLarLlng 2 days before enLerlng Lhe
endemlc area. Whlch one of Lhe followlng ls Lhe number of
Malarone aedlaLrlc LableLs LhaL he/she wlll need for Lhe full course
of LreaLmenL?

A 30

8 46

C 48

D 60

L 90

?ou may use Lhls space for your rough worklng.






























21
34(Ca|c). A cream conLalns Lhe followlng lngredlenLs:

ropylene Clycol hLur 20
lracLlonaLed CoconuL Cll hLur 12.3
Sodlum Pydroxlde hLur 0.01
urlfled WaLer hLur Lo 100.

Whlch one of Lhe followlng ls Lhe welghL of lracLlonaLed CoconuL Cll
hLur needed Lo produce 2300 kg of Lhe cream?

A 31.23 mg

8 312.3 mg

C 3.123 kg

D 31.23 kg

L 312.3 kg

?ou may use Lhls space for your rough worklng.

























22
3S(Ca|c). 1he paedlaLrlc surgery wards aL your hosplLal rouLlnely use lbuprofen
(40 mg/kg dally ln 3 dlvlded doses) and paraceLamol (60 mg/kg dally ln
4 dlvlded doses). Whlch one of Lhe followlng glves Lhe mosL
approprlaLe doses of lbuprofen and paraceLamol for a chlld welghlng
16 kg?

A lbuprofen 160 mg Lds + paraceLamol 240 mg qds

8 lbuprofen 200 mg Lds + paraceLamol 240 mg qds

C lbuprofen 200 mg Lds + paraceLamol 320 mg qds

D lbuprofen 320 mg Lds + paraceLamol 960 mg qds

L lbuprofen 640 mg Lds + paraceLamol 960 mg qds

?ou may use Lhls space for your rough worklng.






























23
36(Ca|c). A paLlenL ls prescrlbed Creon 10 000 capsules. Clven LhaL he Lakes 4
capsules each day, whlch one of Lhe followlng ls Lhe quanLlLy of
amylase LhaL he wlll Lake ln 1 week?

A 2,240 unlLs

8 16,800 unlLs

C 22,400 unlLs

D 224,000 unlLs

L 280,000 unlLs

?ou may use Lhls space for your rough worklng.































24
37(Ca|c). Mr !, a 36-year-old man, ls admlLLed Lo hosplLal wlLh chesL palns of
two hours duration. A myocardial infarction is diagnosed and Mr ! ls
sLarLed on an acceleraLed reglmen of LreaLmenL wlLh alLeplase. Mr !
welghs 83 kg. Pow many unlLs of alLeplase wlll he recelve ln LoLal?

A 48.8 mllllon

8 30.0 mllllon

C 32.2 mllllon

D 36.4 mllllon

L 38.0 mllllon

?ou may use Lhls space for your rough worklng.
































23
38(Ca|c). Mr M has developed a corneal ulcer ln hls rlghL eye and ls prescrlbed
clprofloxacln eye drops. An exLracL from hls prescrlpLlon ls glven
below:

Clprofloxacln eye drops 0.3

uay 1: lnsLll CnL drop lnLo Lhe 8lCP1 eye every 13
mlnuLes for 6 hours Lhen every 30 mlnuLes

uay 2: lnsLll CnL drop lnLo Lhe 8lCP1 eye every
hour

uays 3 Lo 21: lnsLll CnL drop lnLo Lhe 8lCP1 eye
every 4 hours

Apply Lhe drops LhroughouL Lhe day and nlghL



Clven LhaL 13 drops are equlvalenL Lo 1 mL, whlch one of Lhe
followlng ls Lhe number of 3 mL boLLles of clprofloxacln eye drops
LhaL Mr M wlll requlre for Lhe 3 week course?

A 1 boLLle

8 2 boLLles

C 3 boLLles

D 4 boLLles

L 3 boLLles

?ou may use Lhls space for your rough worklng.















26
D|rect|ons for quest|on 39(Ca|c). lor each numbered quesLlon selecL from Lhe llsL
above lL Lhe one leLLered opLlon whlch ls mosL closely relaLed Lo lL. WlLhln Lhe group
of quesLlons each leLLered opLlon may be used once, more Lhan once, or noL aL all.


uest|on 39(Ca|c) concerns Lhe followlng welghLs:

A 0.1 mlcrograms

8 0.01 mg

C 1 mg

D 10 mg

L 100 mg

SelecL from A Lo L, whlch one of Lhe above ls:


39(Ca|c). Lhe mosL approprlaLe LoLal dally dose of rograf (Lacrollmus) capsules
followlng a llver LransplanL for a 10-year-old chlld welghlng 34 kg?


?ou may use Lhls space for your rough worklng.





















27
D|rect|ons for quest|on 40(Ca|c). 1he quesLlon ln Lhls secLlon ls followed by Lhree
responses. CNL or MCkL of Lhe responses ls/are correcL. ueclde whlch of Lhe
responses ls/are correcL. 1hen choose:

A lf 1, 2 and 3 are correcL

8 lf 1 and 2 only are correcL

C lf 2 and 3 only are correcL

D lf 1 only ls correcL

L lf 3 only ls correcL

D|rect|ons Summar|sed
A
1, 2, 3
8
1, 2
only
C
2, 3
only
D
1
only
L
3
only

40(Ca|c). Mr C who welghs 80 kg and ls 1.8 m ln helghL has been dlagnosed
with Hodgkins disease. His doctor has prescribed lomustine 120
mg/m
2
once every slx weeks for hlm. Whlch of Lhe followlng
sLaLemenLs regardlng Mr C and hls LreaLmenL ls/are correcL?

Body surface area (m
2
) =

weight (kg) x height (cm)

3600



1 Mr Cs body surface area is 2 m
2


2 Lhe correcL dose of lomusLlne for Mr C ls 240 mg

3 Mr C wlll requlre 6 capsules for each dose

?ou may use Lhls space for your rough worklng.








LND CI ULS1ICNS
Now go back and check your work