Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
com
Digestive and Liver Disease 40 (2008) 650658
Mini-Symposium
OLGA staging for gastritis: A tutorial
M. Rugge
a,b,
, P. Correa
c
, F. Di Mario
d
, E. El-Omar
e
, R. Fiocca
f
,
K. Geboes
g
, R.M. Genta
h
, D.Y. Graham
i
, T. Hattori
j
, P. Malfertheiner
k
,
S. Nakajima
l
, P. Sipponen
m
, J. Sung
n
, W. Weinstein
o
, M. Vieth
p
a
Department of Medical Diagnostic Sciences & Special Therapies (Pathology Section), University of Padova, Italy
b
Veneto Institute of Oncology (IOV-IRCSS), Padova, Italy
c
Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
d
Department of Clinical Sciences, Section of Gastroenterology, University of Parma, Italy
e
Department of Medicine & Therapeutics Institute of Medical Sciences, Aberdeen University, UK
f
Department of Surgical, Morphological & Integrated Disciplines (Anatomic Pathology Section), University of Genova, Italy
g
Department of Pathology, Catholic University of Leuven, Belgium
h
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
i
Michael E. Debakey VA Medical Center & Baylor College of Medicine, Houston, TX, USA
j
Department of Pathology Shiga University Medical Sciences, Shiga, Japan
k
Department of Gastroenterology Hepatology And Infectious Diseases, Otto-Von-Guericke-University, Magdeburg, Germany
l
Department of Medicine, Gastroenterology and Healthcare Social Insurance Shiga Hospital, Shiga, Japan
m
Division of Pathology, HUSLAB, Helsinki University Hospital, Helsinki, Finland
n
Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, China
o
Department of Medicine Division of Digestive Diseases, UCLA Center for Health Sciences, USA
p
Institute of Pathology Klinikum Bayreuth, Bayreuth, Germany
Received 1 February 2008; accepted 18 February 2008
Available online 17 April 2008
Abstract
Atrophic gastritis (resulting mainly from long-standing Helicobacter pylori infection) is a major risk factor for (intestinal-type) gastric
cancer development and the extent/topography of the atrophic changes signicantly correlates with the degree of cancer risk.
The current format for histology reporting in cases of gastritis fails to establish an immediate link between gastritis phenotype and risk
of malignancy. The histology report consequently does not give clinical practitioners and gastroenterologists an explicit message of use in
orienting an individual patients clinical management.
Building on current knowledge of the biology of gastritis and incorporating experience gained worldwide by applying the Sydney System
for more than 15 years, an international group of pathologists (Operative Link for Gastritis Assessment) has proposed a system for reporting
gastritis in terms of stage (the OLGA staging system). Gastritis staging arranges the histological phenotypes of gastritis along a scale of
progressively increasing gastric cancer risk, from the lowest (stage 0) to the highest (stage IV).
This tutorial aims to provide unequivocal information on howto consistently apply the OLGAstaging systemin routine diagnostic histology
practice.
2008 Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.
Keywords: Atrophic gastritis; Gastritis staging; OLGA staging