Sexual differentiation in the embryo Gender determined at the moment of conception but 8 weeks before reproductive system becomes differentiated as male or female Female fetus has a developed ovary by 10 weeks Mesoderm (middle layer): develops at 5 weeks conception o 1st structure formed is gonad medulla & cortex Mesophrenic ducts-dominant in males, evolving into efferent ductile, vas deferens, epididymis, seminal vesicle and ejaculatory duct Paramesophrenic ducts-dominant in females, evolving into fallopian tubes, uterus and vagina
Female reproductive system Vulva: Posterior to the mons pubis (lowest portion of the abdomen) that is usually covered with pubic hair. Provides protection for the pelvis Labia majora: 2 folds that protect tissues (highly vascular during pregnancy) Labia minora: 2 folds w/in majora that converge near anus to form fourchette (posterior opening on vagina)
Clitoris: Upper junction of the labia minora consisting of thePrepuce (fold of skin that covers the gland)&secrete Smegma. Rich in blood & nerves, serves as 1 organ of sexual pleasure Vestibule: Oval shaped space that contains the openings to the urethra & vagina o Teach about discomfort associated with chemicals (dyes, soaps) Bartholins (vulvovaginal) gland: visible, secretes clear mucus during sexual arousal Urehtral (Urinary) Meatus: inverted V shape below the clitoris o Hymen: forms border of connective tissue that encircles vaginal introitus Skenes gland: on each side of urethra producing mucus to help lubricate Perineum: skin between vagina and anus o Stretches and becomes thin during labor, often tears o Episiotomy: surgical incision to allow perineal opening
Pelvic floor Provides support and stability for surrounding structures o Consists of: pelvic fascia, pubococcygeal, puborectal, illiococcygeal muscles Relaxes and contracts during labor
Organs Ovaries: held in pelvis by ligaments: medovarian, ovarian, infundibular o Essential b/c of production of ova for reproduction o Does not become activity until puberty to release ova and hormones o SECRETES ESTROGEN & PROGESTERONE that regulate menstrual cycle Fallopian Tubes o 4 layers peritoneal (serous), subserous (adventitial), muscular & mucous Blood & nerve supply stored in subserous o 3 sections of fallopian tubes Infundibulum: distal opening where ovum enters Ampulla: most common cite of conception Isthmus: proximal end usual site of tubal ligation (tubes tied) o If fertilization does not occur in 24-48 hours, OVUM DIES Uterus: Centrally located between bladder & rectum (pear shaped) w/ 2 major functions o 1. Permit sperm to ascend to fallopian tubes o 2. Provide nourishing environment for zygote ( it protects & nurtures growing embryo) o If no conception: uterus sheds outermost layers of endometrium (menstruation) o Consists of: Corpus: layers are perimetrium, myometrium, endometrium Perimetrium: outer most layer Myometrium: middle layer consisting of smooth muscle in 3 directions Endometrium: twiinner most layer shed during menses Isthmus: midway b/w uterine body (site of low C-section) Cervix: lower end of the uterus and opens into the vagina Secretes mucus for lubrication, barrier against sperm penetration into uterus during non-fertile periods, provides pathway for sperm during fertile periods, creates alkaline environment for sperm& forms a solid plug called operculum to protect pregnancy from outside pathogens o Fundus: Need to know position & height prenatal and post-partum o Uterine pain nerve fibers reach the spinal cord at level T11 & T12 Vagina: Acidic at pH 4.5-5.5 & has 5 functions o Lubrication during intercourse o Stimulate penis during sex o Act as receptacle for semen (apex is known as the vault) o Transportation of tissue/blood during menses o Lowest portion of the birth canal during birth Ureters, Bladder, Urethra o Mucous membrane-lined tube from bladder used for micturition
Pelvis Bony Pelvis: bony ring that transmits body weight to lower extremities 4 bones: sacrum, coccycx, 2 hip bones During labor, ischial spines serve as a landmark for assessing the level of the fetal presenting part into the pelvis True/False Pelvis o True: outlet lower portion located below lineaterminalis 3 parts: pelvic inlet, midpelvis, pelvic outlet o False: inlet & upper portion of hip bones, support pregnant uterus Diameters o Pelvimetry: measurements to predict feasibility of birth (inlet, midpelvis, outlet) TYPES o Gynecoid: traditional (50%) best suited for birth Inlet, midpelvis and outlet are largest Inlet is round-oval shaped, ischial spine less prominent, short and deep sacrum, wide pubic arch o Android: like male pelvis (23%) Inlet: or heart-shaped with more bony prominences which can cause difficulty during fetal descent o Anthropoid: ape-like (24%) Pubic arch is narrow & inlet is OVAL shaped (ant to post) o Platypelloid: CANT GIVE BIRTH due to transverse presentation of fetus Inlet is laterally wide, sacral/ischial bony prominences w/ wide suprapubic arch
Breast: Nipples, areola & Montgomery tubules 1 function is lactation to provide nutrition to offspring decrease of estrogen post-partum triggers increase of prolactin stimulating milk production oxytocin (from posterior pituitary/hypothalamus) is responsible for ejection of breast milk Montgomery tubules: secretes fatty substance for lubrication/protection of nipple & areola during breastfeeding
Hypothalamus Hormones Gonadotropin-releasing hormone (GnRH) o Stimulates release of FSH & LH when Estrogen and Progesterone decrease
o Females: affects follicular growth, ovulation and corpus luteum o Males: affects spermatogenesis (production of sperm) Corticotropin-releasing hormone (CRH) o Regulates ACTH to activate sympathetic nervous system o Reduces chances the mothers immune system will reject embryo Growth-hormone releasing hormone (GH-RH) o Stimulates the production of growth hormone (GH) Growth-hormone inhibiting hormone (GH-IH) or somastatin Thyrotropin-releasing hormone (TRH) o Regulates T3 & T4; also stimulate prolactin Prolactin-inhibiting factor (PIF) or prolactostatin o Inhibits synthesis and production of prolactin Pituitary Gland Hormones TSH or thyrotropin: regulation of endocrine function of thyroid ACTH or corticotropin: controls development/function of adrenal cortex Prolactin: stimulates maturity of mammary glands during pregnancy o Initiates milk production & inhibits stimulation of FSH and LH (reason why breastfeeding women usually dont conceive) GH or somatotropin: stimulates cell and growth production o Also resp for: muscle mass, Ca+ retention, bone mineralization, organ growth, protein synthesis & stimulation of immune system Gonadotropins (gonad-stimulating hormones) o FSH & LH both stimulate & inhibit ovaries by producing +& feedback of estrogen and progesterone by the ovaries Oxytocin (released by posterior pituitary) o Stimulates uterine contractions & release of milk o Synthetic form available that can be given during labor to enhance contractions, promote expulsion of placenta & minimize bleeding Gonad Hormones Estrogen: HIGH in women of childbearing age o Responsible for 2 sex characteristics (breasts, hips, butt, mons pubis) o Helps regulate menstrual cycle by stimulating proliferation of endometrial lining to prepare for pregnancy Progesterone: helps regulate menstrual cycle o Decreases uterine motility and contractility (relaxes smooth muscles) o prepares uterus for embryo implantation& breasts for lactation o HIGH during pregnancy Other hormones Human chorionic gonadotropin (hCg) **important in early pregnancy** o Increased levels in blood means pregnant o Produces trophoblasts, outer layer of blastocyst which become the baby o Maintains corpus luteum by keeping levels of estrogen & progesterone elevates until placenta is developed Prostaglandins: during pregnancy, helps initiate labor o Cause vasoconstriction & muscle contractions leads to tissue ischemia and pain associated with PMS Relaxin: produced by corpus luteum& detected by the 1 st missed menses o Aids in softening & lengthening of cervix, also works on myometrial smooth muscle to promote uterine contraction
Sexual maturation Puberty: biological time frame between childhood and adulthood characterized by physical changes that lead to sexual maturity o Menarche: 1 st menstrual period (9-15 y/o, avg 12.4 y/o) FSH stimulates ovaries, LH promotes ovulation, corpus luteum left behind producing progesterone Menstrual cycle and Reproduction: periodic d/c of bloody fluid from the vagina o THE CYCLE: changes that occur in uterus, cervix, &vagina associated w/ menstruation Avg. time: 28-32 days The Uterine (endometrial) cycle o Menstrual Phase: time of vaginal bleeding(DAYS 1-6) Triggered by declining levels of estrogen and progesterone s) Prostaglandins released by uterus to cause contractions of smooth muscle to decrease risk of hemorrhage (may cause dysmenorrhea) Can also cause H/A & nausea Menstrual fluid consists of endometrial tissue, blood, cervical/vaginal secretions, bacteria, mucus, leukocytes, prostaglandins o Proliferative phase: end of menses through ovulation (DAYS 7-14) Estrogen is low but increases as uterine lining begins to thicken
o Secretory phase: prior to menses (DAYS 15-26) Increasing amounts of progesterone, making uterus suitable for implantation
o Ischemic phase: onset of menses (DAYS 27-28) Estrogen and progesterone levels are low to endometrium Endometrium becomes pale, vessels rupture. BEGIN DAY 1 o Hypothalamic-pituitary-ovarian cycle Hypothalamus and ant. pituitary communicate through portal system Important hormones: GnRH, LH, FSH, estrogen and progesterone o Follicular Phase: DAY 1 of menstrual cycle beginning w/ bleeding, ends w/ ovulation About 14 days in length GnRH stimulates release of LH & FSH LH stimulates theca cells of ovaries to produce androgens (ie estrogen) FSH stimulates ovary to produce androgens to prep a mature ovum Ovum is capable of fertilization 12-24 hours after ovulation The follicle that contained mature ovum stays in ovary, becomes corpus luteum o Luteal phase: Begins at ovulation and ends with onset of menses (14 days) If not pregnant corpus luteum dominates over 2 nd half of menstrual cycle and regresses after 14 days
Body changes related to menstrual cycle and ovulation o Spinnbarkheit: elasticity of cervical mucus (to see if woman is ready to conceive) o Ferning: test to see if woman is ready to conceive by through crustallization of mucus o Body Temperature increases 0.3-0.6 C 24-48 hours after ovulation Cessation menses: Menopause (last period) o Climacteric phase: Due to decrease in ovary function o Perimenopausal phase: # and production of follicles decrease Experience hot flashes, vaginal atrophy, mood alterations, skeletal bone loss
Ch 6: Human Sexuality and Fertility Sexuality and Reproductive Health Care Must understand the womans views of her situation and asses her needs, values, beliefs and support system Nurses Role: educator, counselor, care provider 4 Stages of Human Sexual Response o Excitement, Plateau, Orgasmic, Resolution Sexuality: Hetero, Homo, Bi (lesbian have increased risk of breast cxr due to not breastfeeding) Promotion of . Sexual dysfunction: manifested in the form of pain, arousal d/o, orgasmic d/o, lack of desire Dyspareunia: painful intercourse Establish trusting relationship o Obtain sexual Hx: STI, dyspareunia, post-coital bleeding, and frequency of sex o Dont judge adolescents for their sexual behavior o Discuss chronic conditions affecting fertility: endometriosis or polycystic ovarian disease Contraception: find what works best for that patient o Medication free: identify fertile periods and avoid sex during that time o Coitus interuptus: withdrawal or pull-out method o Lactational amenorrhea: mother breast feeds since birth and does not menstruate o Abstinence: No sex, No baby o Barriers: inserted or applied prior to coitus KEY is consistent and correct use Latex barriers work best IF NOT ALLERGIC Diaphragm: fitted by nurse/physician filled with spermicide inserted 6 hrs before remains in place 6hrs after sex. There is increased risk for UTI. Not used during menses bc risk of toxic shock syndrome (rare but fatal) Refitted q2years, teach pt how to insert it Cervical cap: 74% like diaphragm but more difficult Condoms 85% effective Spermicide: chemical barrier that cause death of sperm before entering cervix Do not douche after sex to increase effectiveness of spermicide (6 hrs) Contraceptive sponge: (84-87%) fits over cervix allowing 24 hour protection, do not leave on >30 hrs o Hormonal methods: medication, patches, injectibles, subdermal plants, other devices KNOW ACHES: Abd pain, Chest pain, H/A, Eye problems, Severe leg pain S/E can include irregular bleeding, depression, cyclic weight gain Contraindicated in smokers, older than 35, HTN, uterine bleeding, DM for 20+ yrs, & those at risk for DVT or pulm embolus Oral: contain estrogen as ethinyl estradiol Prevents release of FSH: follicle is unable to form and prevents ovulation More effective when used w/ progestins: creates thick cervical mucus, produces hostile sperm environment, caused endometrial atrophy Meds the decrease effectiveness: rifampin, isoniazid, barbiturates, griseofulvin, acetaminophen, and anticoagulants
Low-dose progestin pills: NO ESTROGEN and cant miss a dose Transdermal patch: applied to large muscle weekly for 3 weeks, then 1 week off Vaginal ring: Contains estrogen and progestin Inserted in vagina on 5 th day of cycle for 3weeks, removed on 4 th week Do not remove before, during after sex. Dont douche Emergency contraception (NOT ABORTION): BC fails or unplanned due to rape The morning after pill (Preven (4pills) or Plan B(2pills)): has E & P. IUD: inserted w/in 5 days of unprotected sex for 10 years (EXPENSIVE) Taken w/in 72 hrs, ineffective is implantation has already occurred Injectible: Depo-Provera, Depo-SubQ Provera Lasts for 3 months giving ~150mg progestin injected IM or ~104mg SubQ and site not massaged Given w/in 5 days of menstruation, ensuring no pregnancy Prevents ovulation but can restart after 10 months off of injectibles Teach about amenorrhea Subdermal Implant (Implanon): in inner arm for 3 yrs containing progestin Prevents pregnancy by suppressing ovulation and creating thick cervical mucus hindering sperm penetration Intrauterine device: T shaped device inserted through cervix in uterus Know PAINS: Period late, Abd pain, Infection, Not well, String missing Sterilization: Bilateral tubal ligation and Vasectomy Clinical Termination of Pregnancy: deliberate ending of a pregnancy BEFORE viable age of 20-24 weeks (Thanks to ROE vs WADE) Elective (pt request) or Therapeutic (known fetal disease or d/o) 1 st tri (up to 12 weeks): vacuum, aspiration 2 nd tri: cervical dilation, removal of fetus and placenta called dilation and evacuation laminaria seaweed used to dilates cervix prior to termination Medical Termination of pregnancy (up to 63 days): resembles miscarriage Ashermans syndrome: presence of endometrial adhesions or scar tissue Postabortal syndrome: severe abd cramping & pain from intrauterine blood clots Role in Infertility Care Nurse must be responsible for knowing that sperm at ovum meet Sterility: absolutely prevent reproduction Infertility: no conception after 12mo. of trying o Must begin teaching about ovulation timing and best ways to enhance sperm retention o Meds available to stimulate follicle development; many ova may be released o Sx: endoscopic biopsy (assess endometrial response to progesterone), laparoscopy (visualization of pelvis), microsurgical to correct obstructions to get pregnant o Artifical insemination: placement of partner or donor sperm o In Vitro: conceived in dish, placed in uterus after o Other options: Surrogacy, Adoption, or remain childless o Know ethical considerations w/ donors Be sensitive to couple who can not conceive while providing them with info during the process
Ch 7: Conceptions and Development of the Embryo and Fetus Basic concepts 46 chromosomes, 23 pairs from maternal & paternal gamete) (22 autosomal, 1 set of sex) Fertilization occurs about 2 wks after beginning of last period Gestation is length of time from conception to birth Cellular division: Meiosis and Mitosis (2 identical daughter cells) Some abnormalities: Turners and Klinefelters Inheritance of disease Multifactorial: combination of genetic and environment (Cleft lip, neural tube defects) Unifactorial: traits or d/o caused by a single gene o Autosomal dominant: i.e. a family w/ generations of a d/o due to gene mutations Huntingtons: progressive disease of CNS by involuntary writhing, ballistic mvmnt Achondroplasia: dwarfism Neurofibromatosis: progressive d/o of nervous system forming tumors on body o Autosomal Recessive: each parent has (25% chance of passing to offspring) PKU Cystic fibrosis Tay-Sachs Galactosemia o X-linked dominant: Fathers 100% chance giving to daughter (XX) o X-linked recessive: more common than dominant and common in male Hemophillia A Duchennes Implantation Oocyte/sperm meet in fallopian tube Zygote propelled by cilia/peristalsis; reaches uterine cavity 3-4 days after fertilization, zygote becomes morula then blastocyst ~10 days after fertilization, nidation occurs (implantation of fertilized ovum into endometrium) Blastocyst is buried beneath the endometrial surface Placenta: develops from trophoblast (essential organ for transfer of nutrients , O2, waste) o Lacunae developed by trophoblasts invading endometrium space Fills with fluid and nourishes the embryoblast (the fetus) o Hormones: hCg maintains corpus luteum until placenta can do that Human placental lactogen: regulates fetal glucose/promotion of fetal growth through macronutrients Progesterone: maintains pregnancy, prevents maternal rejection of fetus Estrogen: for growth; increases during pregnancy o Placenta is for oxygenation and waste elimination Progesterone vs Estrogen; Estrogen vs Prolactin; know the differences
Development of Embryo and Fetus Yolk Sac: Develops 8 to 9 days after conception o Essential for transfer of nutrients during second and third weeks of gestation o Hematopoiesis (formation of RBC) o Atrophies and is incorporated into umbilical cord Umbilical Cord: located at center of placenta, 55 cm long (21 in); 1 to 2 cm diameter o Vessels: one vein, two arteries (carries de-oxygenated blood) o Whartons Jelly: protects umbilical cord from compression (the thicker the healthier) Fetal Circulation o Heart begins to beat and circulate blood by end of third week (22 days) o Umbilical vein: blood from placenta to fetus o Low Po 2 important to maintain fetal circulation o Three unique shunts on the umbilical cord Ductusvenosus: bypasses liver and enters inferior vena cava Foramen ovale: right & left atria to supply blood to head, upper and lower extremities Ductusarteriosus: returning blood bypasses lungs Fetal membranes and amniotic fluid o Chorion: forms 1 st ; is the outer membrane that forms the fetal portion of the placenta Encloses amnion, embryo, and yolk sack Contains villi used in genetic testing o Amnion: thin, inner membrane that contains amniotic fluid o Amniotic fluid is VITAL for growth an development Protects and cushions, temp regulation, symmetrical growth, freedom of movement, fetal lung development Fluid present at 3 weeks, fetus swallows 600ml q4hrs At 24 weeks, 800ml present, composed primarily of urine and lung secretions Slightly alkaline containing antibacterial o Amniotic fluid index: test by measuring 4 quadrants Significance??? At full term, AFI should be 800
Human growth and development Pre-Embryonic Period: First 2 weeks after conception o Rapid cellular multiplication and differentiation o Establishment of embryonic membranes and primary germ layers Embryonic Period: 3rd week through end of 8th week o Organogenetic period: formation, differentiation of all organs o Germ layers (pg 176): ectoderm, endoderm, mesoderm o Fetus is most vulnerable from 2-8 weeks (teach mother care) Fetal Period: 9th week until birth or termination of pregnancy o Rapid body growth and differentiation of tissues, organs, and systems o Weeks 9 to 12: external genitalia present at 12 wks Body growth increases- weight triples & length doubles Ossification centers appear Intestines leave umbilical cord, enter abdomen Urine production begins o Weeks 13 to 16 Very rapid growth Coordinated movements of limbs Ossification of skeleton o Weeks 17 to 20: Growth slows down By 20 weeksfetus 300 g and 19 cm (7.3 in) Vernixcaseosa&Lanugo o Weeks 21 to 25: Gains weight, Skin pink, Rapid eye movements, Surfactant by 24 wks o Weeks 26 to 29: If born, fetus may survive o Weeks 30 to 40: Strong hand grasp reflex&Orientation to light 38 to 40 weeks: 30003800 g and 4550 cm (17.319.2 in)
Threats to Embryonic and Fetal Development Chromosomes, teratogens, medications and other substances, vitamins, alcohol, tobacco, caffeine, drugs, radiation, and lead TORCH infections o Toxoplasmosis consumption of raw/uncooked meat; cat litter o Other infections-chicken pox or HIV o Rubella German measles o Cytomegalovirus (herpes family): results in spontaneous abortion o Herpes Simplex Virus: causes spontaneous abortion Nurses Role in Prenatal Evaluation o Assessment: cultural, emotional, physical, and physiological factors o Teaching and education, o Gathering of health history; genetic disorders andprenatal tests Maternal Age and Chromosomes: age 35 and above o Increased risk of chromosomal abnormalities (Down syndrome - trisomy 21) o Deletion- loss of portion of DNA from chromosome or translocation o Trisomy 18- Edwards syndrome&Trisomy 13- Patau syndrome These infants usually die within the first 3 months Multifetal Pregnancy o Monozygotic (identical) - Develop from one zygote (occurs at end of first week) o Dizygotic - Develop from two zygotes with separate amnions and chorions Nurses role in minimizing Threats to Embryo/Fetus o Assessment: Environmental & lifestyle risks, physical & psychosocial well-being o Counseling: assess knowledge bc may just be improperly educated and misinformed
Ch. 8: Physiological Preparation for Pregnancy Physiological Preparation Pituitary gland: Secretes hormones that influence follicular development, prompt ovulation, and stimulate the uterine lining preparing for pregnancy o Progesterone: primarily responsible for maintenance of pregnancy, relaxes smooth muscle, & slows GI to ensure absorption for fetus Causes vasodilation to increase blood flow to all body tissues Ensures adequate nutrition and removal of wastes o Estrogen: primarily for growth (breasts and uterus) and increases uterine contractility to prep muscles for labor Causes uterine muscles to contract o hCg: secreted by trophoblast to prompt corpus luteum to continue progesterone production until placenta can take over Ovarian Hormones: maintain endometrium, provide nutrition to zygote, aids in implantation, reduction in chance of spontaneous abortion Placenta Hormones: Essential to the survival of pregnancy and fetus o protects fetus from maternal immune response, creates loosening of pelvis and other joints Reproductive system Uterus: from pear-shaped to a soft, enlarged globular structure o E&P cause myometrial cells and muscle fibers to undergo hyperplasia and hypertrophy, allowing the uterus to stretch and grow as the fetus does o Braxton-Hicks: irregular/painless contractions that may occur around 16 wks which prepare the muscles for activity of labor (no dilation of cervix) o After implantation, the endometrium lining is termed the decidua containing 3 layers Decidua vera: external layer and has no contact with fetus Decidua basalis: beneath the site of implantation Decidua capsularis: covers the embryo o By term, uterine wall thins 0-6 inches Cervix: o Chadwicks sign: earliest sign of pregnancy; present with discolored bluish purple hue (due to increased blood flow and engorgement) on cervix, vagina and vulva o Goodells sign: cervical softening related to decrease in collagen fibers of connective tissue, increase in vascularity, and tissue hyperplasia and hypertrophy o Operculum: mucus plug o Leukorrhea: white vaginal d/c resulting from hyperplasia of the vaginal mucosa and increased mucus production from endocervical glands Teach pt to call HCP if d/c smells, becomes bloody, thicker, yellow, green, etc
Vulva/Vagina: gets thicker, developing rugae which allow for stretching during delivery o Teach pt not to douche bc area has become more acidic (pH3.5) to inhibit growth of bacteria into canal. o Increased risk of yeast infx due to increased in glycogen Ovaries: Ovulation ceases during pregnancy due to increased E & P, inhibiting FSH & LH o Only responsibility is progesterone production corpus luteum until placenta takes over Breasts: hormone Melanotropin causes tenderness and darkening of areolla o Montgomery tubules: enlargement for production of nipple tissue lubrication o Striaegravidarum: stretch marks develop as breast stretch o Colustrum may leak around 2 nd trimester o TEACH: bra sizes, breast feeding, cotton bra liners for secretions
Integumentary: assess womens self-concept and body image caused by changes from E & P o Linea negra, increase in sweat activity and oiliness of skin acne o Cholasma (melisma gravidrum): presents as raccoon eyes o Stretch marks, moles, freckles are a problem o Photosensitivity/sunburn, angiomas, palmar erythema caused by estrogen o Alterations in hair and nail growth: reassure mother this is all normal
Neurological: c/o decreased attention span, poor concentration and memory lapses o Sleep disturbances: use daytime naps to help o Carpal tunnel: develops in 3 rd tri due to edema in wrist and pressure on median nerve Elevate hand at night to help decrease edema o Episodes of syncope: due to orthostatic hypotension or IVC compression by uterus Vena Cava Syndrome can occur from coughing, constipation Teach to get up slowly and lie on left side to decrease pressure on IVC
Cardiac: Maternal heart is pushed upward and laterally left o Hypertrophy results from increased blood volume and cardiac output o 1 st and 3 rd heart sounds and systolic murmurs are exaggerated upon ausculatation call MD if symptomatic of cardiac issues o Blood Volume: increases during 1 st tri & peaks at term, decreases by 2 wks post partum Plasma and erythrocyts volume increase due to increased need of O2 for placenta 80% of extra blood goes to placenta Renal blood flow increases 30-50% o Iron: fetal need is greatest last 4 weeks of pregnancy o Pseudoanemia: CBC, H&H may appear low due to increased volume Teach to drink plenty of fluids and diet high in protein and iron o Leukocytes, Proteins, Platelets and Immunoglobulins WBC increase to 5000-15000mm3 & can increase to 25000 during labor/post partum increased risk for infx during pregnancy due to decrease leukocyte funtion Sedimentation rate increases (pT, PTT, INR) due to increase fibrinogen, which causes hypercoagulability Is pt at risk for DVT or embolism? Only maternal IgG can be transported across placenta, not IgM IgA is found in breast milk: for respiratory, GI & GU protection from infx o Cardiac Output: increases and peaks at 20-24 wks
Respiratory: Tx mother to relax and take deep, slow breaths with head elevates o Tidal volume increase 30-40% due to E & P; may experience dyspnea due to rise of diaphragm Estrogen prompts hypertrophy and hyperplasia of lung tissue Progesterone decreases airway resistance by causing relaxation of the smooth muscles of the bronchi, bronchioles and alveoli These changes increase O2 consumption
GI: N/V in 1 st tri r/t to increase in hCg and altered carb metabolism o Alteration in taste and smell, nonspecific gingivitis, epulisgravidarum o Pyrosis: heart burn caused by progesterone, which relaxes esophagus, causing reflux o Pytalism: increased saliva production o Gall bladder issues: cholecystitis, cholestasia caused by progesterone, which relaxes gall If mother has high cholesterol, gallstones may form Avoid food high in fat
GU: during 1 st tri, bladder in pelvic organ compressed by the uterus o Progesterone induces relaxation of the urethra and spinchter causing urinary urgency, frequency and nocturia o In 2 nd tri, pressure is relieved but returns in 3 rd tri as a result of fetal descent o GFR increases up to 50% = increased reabsorption and high levels of glucose
Eyes, ears, nose, throat o Blurred vision caused by corneal thickening associated with fluid retention and IOP o Ears normally dont change o Progesterone causes increase in mucus production stuffy nose and congestion o Epistaxis common, rhinitis common o Throat: dysphagia caused by increased relaxation of smooth muscle in esophagus
Endocrine: o Thyroid: Increase in size (bc of E&P) & activity during pregnancy (T3 & T4 increase) BMR increases Heat tolerance and elevation of HR and CO develop o Parathyroid: estrogen causes increases in size Regulation of Ca+ and Phosphate metabolism and increase in 2 nd /3 rd tri for fetus o Ca+ important and should be taking 1200-1500mg/day
Pituitary and placenta: anterior pituitary stimulated by hypothalamus o Prolactin: needed for initial lactation, inhibited by the increase of E & P until post partum o Oxytocin: from posterior lobe causes uterine contractions and stimulates milk ejection o Vasopressin: Vasoconstrictor from posterior lobe causing fluid retention leading to increase of maternal BP and exerts o Human placental lactogen acts as GH to fetus By increasing # of fatty acids to maternal metabolic needs and decreasing maternal glucose utilization, the result is an increased glucose availability for the fetus o Anterior secretes thryoptropin (increases BMR), adrenotropin (increases fluid retention)
Adrenals: Cortisol allows the body to respond to stressors o Levels increase due to increased renal secretion o May take up to 6 weeks post partum for cortisol level to normalize o Aids in regulation of protein and carb metabolism o Aldosterone increased in 2 nd tri (increases Na+ reabsorption leading to increased BV)
Pancreas: secretes insulin due to increase of carb metabolism o Beta cells increase during pregnancy o Prostaglandins: lipid substance found in the female reproductive tract & uterine decidua Decreased levels contribute to HTN and preeclampsia At term, increased release from the cervix may contribute to onset of labor
Musculoskeletal: o Abd wall weakens and rectus abdominus muscles separate (diastasis recti) Caution for abd hernia o Lumbar lordosis develops: anterior convex of spine to compensate for center of gravity o Relaxin: produced by placenta which causes laxity of ligaments o Pubis symphisis separates at week 28-30 producing a waddle gait Stretching and hypertrophy of round ligaments surrounding uterus cause sharp groin pain Must support lumbar and encourage good posture Pain may be present; apply heat to reduce pain o Teach to increase calcium in diet, fortified OJ and dark green leafy veggies Due to increased calcitonin which decreased bone resportion o Calf cramps may also be present due to Calcium and phosphate imbalance
Physiological Changes of pregnancy by trimester 1 st : pain/tingling in breasts, N/V, fatigue, mood swings o REPORT: vaginal bleeding, ABD cramping/pain 2 nd : Abd enlargement, skin pigmentation, striaegravidarum, vascular spiders, constipation, heartburn, leg cramps, leucorrhea, groin pain o REPORT: vaginal bleeding, fever, increased pulse, decreased/absent fetal movement, unrelenting N/V, swelling of face or fingers, headaches or visual disturbances 3 rd : dyspnea, lower extremity cramps, constipation, indigestion, heartburn, reflux, pedal edema, fatigue, vaginal d/c, urinary frequency, Braxton-Hicks contractions o REPORT: visual disturbances, headache, hand and facial edema, fever, vaginal bleeding, ABD pain, uterine contraction, premature rupture of the membrane
Psychosocial Adaptations during pregnancy Developmental and Family Changes o Duvalls stages of family development Home must be reorganized to accommodate the infant Duties and responsibilities must be realigned Money management needs to be altered Couples sexual relationship must adapt Emotional changes Expand their knowledge
Maternal Tasks and Role Transition: RUBIN to develop self concept of mother Acceptance of the Pregnancy: known as binding in Acceptance of the Child: Critical for successful adjustment to pregnancy, must develop unconditional acceptance Reordering Relationships: must reorder relationships to allow for the child to fit into existing family structure o If she is having her first child she may grieve the loss of her carefree life o Work through doubts of her ability to be a good mother Seeking Safe Passage Through Pregnancy, Labor and Birth: nesting o Increased worry during and after 7 th month o Childbirth preparation classes can help with fear and anxiety Developmental Tasks and the Pregnant Adolescent o Tasks are associated with growth and maturity o May not be able to accept the reality of the unborn child o Paternal Adaptation to Pregnancy o Men may view pregnancy as positive proof of their masculinity and play a dominant, supporting role o When they find no value, the fail to develop any sense of responsibility Observer: Father is passive and detached Expressive:Father attempts to experience the pregnancy as much as possible Instrumental:Father is the caretaker Couvade is the observance of certain rituals and taboos; pregnancy related sx like weight gain and N/V Adaptation of Siblings and Grandparents o Children may express excitement/anger, regression of behavior, want to nurse or drink from a bottle o Engage child with the developing fetus o Grandparents are often very excited o May express concern for the mothers health and fetal health Cultural Influences o Nurse needs to explore cultures and document specific beliefs and needs o Native Americans and Latinos view pregnancy as normal and not an illness o African nations impose rigid taboos concerning what they eat, drink, wear and do o Middle Eastern cultures view pregnancy as womans work o Asian cultures need a harmonious balance (yin and yang) Anticipatory Guidance: for nurses to help guide mother through troubles of pregnancy
Ch 9: The Prenatal Assessment Concerns over self-preservation As the nurse: listen, educate, respect mother and choices Goals include: o Recognize deviations from the norm o Provide individualized, evidence based care o Provide culturally appropriate prenatal education o To empower women to become actively involved in their pregnancy by being informed recipients and informed decision makers Prenatal care starts in 1 st tri, then every 4 weeks until 28-32 weeks gestation o Will change to q2wks, then q1wk after 36 weeks CARE: remain non-judgmental, verbalize pt wishes, use understandable words o Communicate: exchange info spoken or written o Advocate: defend and support o Respect: to feel/show admiration, pay attention o Enable: provide resources/authority/opportunity to do something Diminishing Stress o Incorporate continuity of care (ie same nursing staff, HCP) o Eustress (normal/healthy level) & Eustress (exceeding level w/ inability to deal)
First prenatal visit BUILD RAPPORT to gain new mothers confidence, use of therapeutic communication Should take place as early in the pregnancy as possible Collect: pregnancy hx, med hx, exercise and nutrition patterns, financial income, psychosocial hx, and lifestyle choices Genetic Tests??
Provide a user-friendly service that is efficient, caring and patient centered DEEPER CARE o Diet: whole grains, green/yellow/orange veggies, dry means, low fat, high Calcium, low mercury content, o Exercise: aerobic o Education: child classes, anticipatory guidance o Play: recharge & reconnect o Expectations: abnormal vs normal expectation o Relaxation: promotes immunity and energy, decrease in BP and stress (YOGA) o Communication: o Attitude: keep positive for overall well-being o Respect: honest, trust, compromise, negotiation o Emergencies: know dangers (vaginal bleeding, decrease in fetal movement, fever over 100.5) 10% of fetal malformations r/t to exposure to hazards o smoking, alcohol, drugs, malnutrition, viruses, pollution Complementary/Altenative therapies o Red raspberry tea is good, blue cohosh is bad
Hx of intimate partner violence Domestic: most common (1 out of 6) Femicide: refers to death of a woman resulting from acts of violence against her o Does pt feel safe going home? RADAR: o Routinely screen every pt o Ask directly, kindly, non-judgmental o Document your findings o Assess safety o Review options referrals Woman may turn to drugs to deal emotionally with abuse (methamphetamines, cocaine, MJ)
Psychological Assessment Loss of a previous pregnancy may affect a womans ability to bond with her present pregnancy May be reluctant to invest in a pregnancy that she fears may not come to fruition
The Obstetric History: Current & Previous Pregnancies GP (gravida parity) Preterm labor is before the 37 th week (20-40% chance of pre-mie) Assess hx of preeclampsia old/new partner?(increases likelihood of it re-occurrence) o Classic symptoms: increased BP and proteinuria Gestational DM: carb intolerance during pregnancy Tx about SIDS: breastfeed, avoid smoking and position baby on the back to sleep
Current Pregnancy: Unexpected does not mean unwanted Know the 1 st day of last menstrual cycle know EDB Testing: hCg in blood as early as 1 day after implantation, 26 days in urine Chemical pregnancy = home test confirms pregnancy but is followed by menses PRESUMPTIVE SIGNS of pregnancy: o Amenorrhea, Morning sickness (N/V), Urinary frequency, Breast tenderness, Perception of fetal movement, striaegravidarum, Fatigue PROBABLE SIGNS o Piskacek sign- uterine asymmetry with soft prominence on the implantation side o Hegars sign- softening of the lower uterine segment o Goodells sign- softening of the tip of the cervix o Chadwicks sign- violet-bluish color of the vaginal mucosa and cervix o Braxton-Hicks sign- intermittent irregular uterine contractions w/o dilation o Ballottement- passive movement of the unengaged fetus POSITIVE INDICATIONS: o Fetal heartbeat o Visualization of the fetus o Fetal movements palpated by the examiner
Estimated Date of Birth (EDB) Based on date of last normal menstrual period assuming that the woman has a 28-day cycle NAEGELES RULE: add 7 days, then subtract 3 months from date of the patients LMP Pill failure results from forgotten pills, poor absorption that may result from various causes such as vomiting, diarrhea, or antibiotic use Pregnancy Classification System Gravid: state of being pregnant Gravida: a pregnant woman Gravidity: number of times a woman has been pregnant regardless of outcome Nulligravida: never experiencing a pregnancy Primigravida: woman pregnant for the first time Secundigravida: woman pregnant for the second time Multigravida: pregnant 3 or more times Parity: number of pregnancies lasting longer than 24 weeks regardless of outcome GTPAL classification system G- Gravida T- number of Term pregnancies P- number of Preterm deliveries Abortions both spontaneous and induced L- number of Living children
Medical History Lack of a family physician r/t: financial difficulties, lack of medical insurance, or cultural/value differences o Refer patient to WIC Dental Health: Promote to reduce the incidence of periodontal disease (gingivitis) o Pregnancy hormones increase plaque and development of periodontal disease o Oral bacteria can enter blood stream into placental membranes (trigger preterm labor) Eye Health: Important for women with HTN, Graves , DM, and for women who wear contacts Immunizations o Rubella is contracted during first 12 weeks of pregnancy, fetus has 90% chance of being adversely affected Typical symptoms: intrauterine growth restriction, cardiac defects, sensorineural defects, cataracts and microcephaly o Hepatitis B focuses on effects on pregnancy, long-term maternal risks(chronic liver disease) Household members and intimate partners should undergo screening Seroconversion: process whereby an individual develops antibodies in response to an infection and subsequently tests positive when screened, due to the presence of the antibodies
Environmental Hazards Air pollution (most common): linked with preterm Tobacco: premature rupture of the membranes, preterm labor, placential abruption, placenta previa, upper respiratory infections, childhood asthma, and wheezing
Gynecological History Diethylstilbestrol (DES): nonsteroidal, synthetic estrogen &several times more potent than natural estrogens Hazardous!!!!! o Used as a preventative treatment to reduce spontaneous abortion or preterm delivery o Linked with infertility, ectopic pregnancies, preterm labor Screening tests: IDs at risk pts&Diagnostic tests: confirms presence of a d/o or disease o Blood type, Rh factor, Antibody (kell, duffy, rubella, varicella, toxoplasmosis, anti-rh), rapid plasma reagent, venereal disease screen for syphllis, HepB o CBC with differential H&H o Testing for antibody to HIV o STDs: presence can cause ectopic pregnancy, spontaneous abortion, preterm labor HIV: transmission occurs transplacentally Mother taking AZT, retrovir& C-section reduces risk of transmission Syphillis: can cause deafness, impaired cognitions, osteochondritis, fetal death Treat with penicillin or erythromycin before 18 week Chlamydia/Gonorrhea Herpes simplex
Preparing Patient for Exam Encourage patient to void (take urine sample tests for ASB) Keep room warm, leave a cover for the patient, ensure privacy Explain what the exam will involve, obtain consent Actively engage the patient during the exam to calm her nerves, explain the process BASE VITALS: know how the woman is progressing with each visit Obtaining Information and Promoting Good Nutrition Increase caloric needs by 300 per day Folic acid increased by 400mcg/day before conception and continued at least through the first 3 months of pregnancy (reduces neural tube defects) Extreme weight loss could indicate hyperemesis Low levels of Vit C predispose women to premature rupture of membrane
Assessment Head/Neck/Lungs: hair loss is common indicative of vit/min deficiency o Enlarged thyroid is common Skin: cholasma, hyperpigmentation, lesions Breasts: changes in nodularity, striae, enlargement and hyperpigmentation of nipples o Colostrum and palpable lymph nodes Abdomen: lineanigra, striaegravidum, bruising Measure fundal height by using a tape measure (around umbilicus @ 20 weeks) Initiate Leopolds maneuvers (determine position of the fetus) o First maneuver determine fetal body part that occupies uterine fundus. Determine the head or the butt occupies the uterine fundus- But feels soft & head feels firm- use the palmar surface of hands to palpate o Second maneuver locate the spine o Third maneuver (Pawlik) - compare fundus w/ lower uterine segment confirm fetus is cephalic o Fourth maneuver- use finger tips of both hands to determine ballottement; engagement Fetal heart auscultation: use least intrusive method - Pinard orfetoscope (120 to 160 bpm) o Most clearly hear directly over fetal upper back (Maternal R or L lower quadrants)
Teen Pregnancy-Nurses role Be an advocate for responsible sexual behavior (be sensitive) Counsel the patient and educate for future responsible sexual decision making Teens more likely to experiment at very early age and get involved in high-risk behaviors like substance abuse, gang involvement, and violence By law, a pregnant minor is an emancipated minor Promote optimal nourishment: increase calcium, magnesium and phosphorous Meeting Developmental Tasks of Adolescence for teen mother to adapt & fulfill role of being a mother, must achieve 4 developmental tasks: o Gain acceptance of pregnancy, Set goals, View self as mother, Grow up Pregnant older than 35 Make sure: healthy, continue care, remain active, have the ability to make appointments Down syndrome triple test: alpha fetoprotein, hCg, estriol 7/2/2013 3:40:00 PM 7/2/2013 3:40:00 PM