To conduct air to the alveolar surface, where gas transfer takes place between inspired air and blood of the alveolar capillaries Lungs are subdivided into 3 zones: ! CO"D#CTI"G $O"E - composed of airways whose walls do not contain alveoli - walls are thick enough that gas cannot diffuse into the adjacent lung parenchyma - it includes the trachea, bronchi and membranous (nonalveolated! bronchioles %! TRA"SITIO"AL $O"E - carries out both conductive and respiratory functions - it consists of the respiratory bronchioles and alveolar ducts - alveolar ducts conduct air to the most peripheral portion of the lung" - #lveoli that arise from the walls of these airways also serve in gas e$change &! RESPIRATORY $O"E - consists of the alveoli whose primary function is the e$change of gases between air and blood The res'iratory (one to)ether with the transitiona* (one constitutes the L#"G PARE"CHY+A The cornerstone of radiologic diagnosis is the %&'(T )#*+,-)#.& The most satisfactory basic or routine radiographic views for evaluation of the chest are: /" posteroanterior and 0" left lateral projections The o'tima* chest ra,io)ra'h is o-taine, in the posteroanterior (.#! view at a targettofilm distance of 10 inches with the patient in the upright position at ma$imum inspiration #*'23#T' .'4'T)#T+,4 56 )#*+#T+,4 Thoracic spine shld be barely seen thru the heart bronchovascular structures can usually be seen thru the heart spine appears to be darker caudally" This is due to more air in lung in the lower lobes and less chest wall" (ternum shld be seen edge on .osteriorly there should be two sets of ribs 1 "on.stan,ar, chest ra,io)ra'hy LORDOTIC PRO/ECTIO": +t is advocated in 3 situations: /" for improving visibility of the lung apices, superior mediastinum and thoracic inlet 0" for locating a lesion by paralla$ 3" for identifying the minor fissure in these suspected cases of atelectasis of the right middle lobe LATERAL DEC#0IT#S it is particularly helpful for the identification of small pleural effusions it is also useful to demonstrate a change in position of an air fluid level in a cavity to ascertain whether a structure that forms part of a cavity represents a freely mowing intracavitary loose body(fungus ball! O0LI1#E PRO/ECTIO" useful in locating a disease process ( pleural pla7ue! (.'%+#L )#*+,-)#.&+% T'%&4+23'(: /" +nspiratory'$piratory radiography - main indication is the investigation of air trapping either general or local i" -eneral air trapping 8 e$emplified by asthma or emphysema ii" Local air trapping 8 there is bronchial obstruction, or lobar emphysema - 0 nd indication 8 when pneumothora$ is suspected and the visceral pleural line is not visible 0" 9alsalva and :uller maneuvers may aid in determining thevsacukar or solid nature of intrathoracic mass 3" 5edside radiography +n patients who are too ill to stand, anteroposterior (#.! upright or supine projections offer an alternative %,:.3T'* T,:,-)#.&6 :ost common indication for the used of %T scan /" 'valuation of suspected mediastinal abnormalities identified on standard chest radiograph 0" (earch for occult thymic lesions 3" determination of the presence and e$tent of neoplastic ;" search for diffuse or central calcification in a pulmonary nodule :iscellaneous indications: /" assisting in the percutaneous biopsy of a lesion such as mediastinal, pleural or pulmonary masses 0" localization of loculated collections of fluid within the pleural space 3" assessment of the size and configuration of the thoracic aorta :ain indication for the use of &)%T /" diagnosis of bronchiectasis 2 0" detection of parenchymal lung disease :#-4'T+% )'(,4#4%' +:#-+4-: - plays an important role in the evaluation of the abnormalities of the great vessels, mediastinum, hila and chest wall" 3LT)#(,4,-)#.&6 - assessment of pleural effusion and distinction of effusions from solid pleural lesions - assessment of the diaphragm - guide to needle biopsy and catheter placement #4#T,:6: .lease review the chest anatomy ATELECTASIS state of incomplete e$pansion of a lung or any portion of it loss of lung volume (collapse! CA#SES O2 COLLAPSE +ntrinsic mass : primary or metastatic neoplasms or eroding lymph nodes +ntrinsic stenosis : T5, inflammatory processes, fracture of a bronchus '$trinsic pressure : enlarged lymph nodes, mediastinal tumor, aortic aneurysm, cardiac enlargement 5ronchial plugging : <5 or mucus accumulation DIRECT SIG"S O2 COLLAPSE *isplaced septa most reliable sign Loss of aeration 9ascular = bronchial signs crowding I"DIRECT SIG"S O2 COLLAPSE 'levation of a leaf of diaphragm (hift of the mediastinal structures toward the side of the affected lobe +psilateral decrease in size of the thoracic cage %ompensatory hyperaeration of the uninvolved lobes &ilar displacement most important indirect sign of collapse L34- &')4+#T+,4 :ore common in left side collapse 3 main locations: /" anterior to the ascending aorta > most common 0" lower thora$ behind the heart 3" under the arch of aorta TYPES ! Resor'tion 3 o-structi4e ate*ectasis 3 occurs when communication between the trachea and alveoli is obstructed may be intrinsic, caused by a tumor, foreign body, inflammatory disease, heavy secretions e$trinsic pressure on bronchi caused by tumor or enlarged nodes or bronchial constriction secondary to inflammatory disease %! Passi4e ate*ectasis intrapleural abnormalities caused by space occupying process that can compress the lung pneumothora$, pleural fluid, diaphragmatic elevation, herniation of the abdominal viscera into the thora$, large intrathoracic tumors &! Com'ressi4e ate*ectasis . intrapulmonary abnormalities is a secondary effect of compression of normal lung by a primary, spaceoccupying abnormality bullous emphysema, lobar emphysema 5! A,hesi4e ate*ectasis . occurs when the luminal surfaces of the alveolar walls stick together hyaline membrane disease, pulmonary embolism, acute radiation pneumonitis, uremia 6! Cicatri(ation ate*ectasis is primarily the result of fibrosis and scar tissue formation in the interalveolar and interstitial space classic cause of cicatrizing atelectasis T5 histoplasmosis P"E#+O"IA: %lassification: /" Lobar pneumonia 0" Lobular pneumonia 3" +nterstitial pneumonia %omplication of .neumonia: /" %avitation organisms (taph aureus (treptococci -r(! bacilli #naerobes types a" Lung abscess > single well defined mass often with air fluid levels" b" 4ecrotizing pneumonia small lucencies or cavities c" .ulmonary gangrene sloughed lung 0" .neumatoceles subpleural collections of air which result from alveolar rupture thin walled seen in children organisms (taph aureus 4 3" &ilar and mediastinal adenopathy T5 and fungi ;" .leural effusion and empyema ?" ,ther complications #)*( 5ronchiectasis )ecurrent pneumonitis Summary of c*inica* c*ues to the etio*o)y of 'neumonia ! Pre4ious*y we** community ac7uire, ?@1@A (trep pneumoniae :ycoplasma pneumoniae virus or legionella pneumophila %! Hos'ita* ac7uire, gr(! .seudomonas aeruginosa Blebsiella pneumoniae 'scherichia coli 'nterobacter species &! A*coho*ism :ost common .neumococcus <re7uent -ram (!, anaerobes, (" aureus 5! Dia-etes me**itus gram (!, (" aureus 6! A*tere, consciousness an, coma gram(!, anaerobes 8! Postinf*uen(a (taphyloccus aureus 9! Chronic -ronchitis with e:acer-ation &aemophilus influenzae Summary of ra,io)ra'hic c*ues to the etio*o)y of 'neumonia ! ;Roun,< 'neumonia (treptococcus pneumoniae %! Com'*ete *o-ar conso*i,ation (treptococcus pneumoniae, Blebsiella pneumoniae ,ther gram (! bacilli &! Lo-ar en*ar)ement Blebsiella pneumoniae, (taphylococcus aureus &aemophilus influenzae 5! 0i*atera* 'neumonia =-roncho'neumonia>? .neumococcus >still common (taphylococcus aureus 6! Interstitia* 'neumonia 9irus, :ycoplasma pneumoniae 8! Se'tic em-o*i (" aureus 9! Em'yema or -roncho'*eura* fistu*a (" aureus, -r(!bacilli, anaerobes @! Ca4itation (" aureus, gr(! bacilli, anaerobic bacteria (treptococcus A! 'u*monary )an)rene Blebsiella pneumoniae, 'scherichia coli &aemophilus influenzae, :" tuberculosis B! 'neumatoce*es (" aureus, gr(! bacilli, &" influenzae, :" tuberculosis, measles ! *ym'ha,eno'athy 5 :" tuberculosis, fungi, virus, :ycoplasma pneumoniae P"E#+O"IAS CA#SED 0Y GRA+ =C> 0ACTERIA ! Stre'tococcus 'neumoniae :ost common community ac7uired pneumonia :ore common in adults )adiograhic features Lower lobes %onsolidation Lobar or sublobar )ound pneumonia in children %! Sta'hy*ococcus aureus :ore common in infants and children )adiograhic features in children %onsolidation Lower lobes .neumatoceles )adiograhic features in adults 5ilateral %avitation 'mpyema &! Stre'tococcus 'yo)enes )adiograhic features %onsolidation (egmental Lower lobes 'ffusion P"E#+O"IAS CA#SED 0Y GRA+ =.> AERO0IC ORGA"IS+S ! D*e-sie**a 'neumoniae :iddle age, elderly patients %hronic lung disease and alcoholic patients )adiologic features Lobar consolidation 5ulging fissures %avitation .ulmonary gangrene %! Escherichia co*i *irect e$tension from -+ C -3 tract (econdary to bacteremia )adiologic features 4ecrosis, multiple cavities Lower lobes &! Pseu,omonas aeur)inosa &ospitalized, debilitated patients Tracheostomy tubes and suction devices )adiologic features Lower lobes, consolidation )apid spread to both lungs :ultiple irregular nodules %avitation 5! Haemo'hi*us inf*uen(ae 6 %,.* 5ronchopneumonia )adiographic features &omogeneous segmental Lower lobes T35')%3L,(+( 3sually deposited in the middle and lower lobes .rimary T5 remains clinically silent *evelopment of delayed hypersensitivity occurs / 3 weeks after inoculation ..* is positive 5y 3weeks .)+:#)6 T5 -hon focus +nitial focus of parenchymal disease )anke comple$ %ombination of -hon focus and affected lymph nodes )adiologic manifestations .arenchymal involvement airspace consolidation )t upper lobe > most common (adult! )ight middle lobe > least common Lymph node involvement &ilar and mediastinal >right paratracheal region (children! #irway involvement Lobar and right sided atelectasis (children! #nterior segment of the upper lobes (adult! .leural involvement .leural effusion is more common in adult (low resolution may occur in 3D months POST PRI+ARY T0 .ulmonary involvement increases ,ften cavitation occus 5ronchogenic spread .leural involvement and C or empyema Eith bronchopleural fistula Tendency to localized in the apical and posterior segment of the upper lobes <ocal areas of consolidation %avities occurs #pical and posterior segments of upper lobes (uperior segments of the lower lobes Tuberculoma 3pper lobe, right more often than the left *+((':+4#T'* T5 /" 5),4%&,-'4+% ,ccurs when e$udate from a cavity or small area of caseation drains into a bronchus #spirated into previously unaffected areas, ,n the same side ,n the opposite side 7 0" &':#T,-'4',3( Leads to miliary T5 '$trapulmonary lesions thru out the body #cute massive hematogeneous (pread causes miliary T5 %hronic spread in smaller amount )esults in the chronic e$trapulmonary foci 3" L6:.&#T+% %ommon in primary T5 )esponsible for involvement with subse7uent enlargement of hilar and mediastinal node ( children! +n adults, hilar and mediastinal nodes .rimary infection )eactivation Pu*monary neo'*asms I! 0eni)n tumors ! Hamartomas %haracteristics #c7uired Tissues normal to organ *isorganized growth ?AFA solitary pulmonary nodules %linical 3@1@ years #symptomatic .athology %artillage <at <ibrous tissue )adiologic features (olitary welldefined pulmonary nodules %# GG /@ A to /?A %T fat and calcium (0?A! II! +a*i)nant tumors ! A,enocarcinoma :ost common of the bronchogenic tumors :ost common type found in women nonsmokers C*inica* features ,ccasionally asymptomatic Patho*o)ic features (low growing :etastasize early #ssociation with fibrosis .eripheral, subpleural Ra,io)ra'hic features .eripheral with lobulated or irregular margins (olitary nodule or mass (piculated border .leural retraction or tethering &ilar or perihilar mass .arenchymal mass with hilar or mediastinal lymphadenopathy 8 %! 0ronchio*oa*4eo*ar carcinoma (ubtype of adenocarcinoma C*inica* features (evere bronchorrhea Ra,io)ra'hic features (olitary nodule :ost common &azy, illdefined HgroundglassI on %T #ir bronchogram %onsolidation :ultiple nodules &! S7uamous.Ce** Carcinoma 0nd most common .redominantly in men .eak incidence at the age of J@ yrs (trong association with cigarette smoking :ost common cause of .ancoast tumor :ost common type of lung %# to cause hypercalcemia C*inica* 2eatures 5est prognosis ,ne third of all lung cancers 'ctopic parathormone production Patho*o)ic features %entral, endobronchial Local mestastases to lymph nodes %entral necrosis
Ra,io*o)ic features Two thirds central 'ndobronchial lesion best seen on %T #telectasis of lung or lobe .ostobstructive pneumonitis ,ne third peripheral Thickwalled, cavitary mass (olidary nodule Su'erior Su*cus Carcinoma =Pancoast tumor> C*inica* features .ain &ornerKs syndrome 5one destruction #trophy of hand muscles Patho*o)ic features :ost common s7uamous cell +nvasion %hest wall 5ase of neck 5rachial ple$us 9ertebral bodies and spinal canal 9 (ympathetic ganglion (ubclavian artery Ra,io*o)ic features #pical mass or asymmetric thickening 5one destruction :)+ :ultiplanar imaging Local e$tension 5! Sma** Ce** Carcinoma :ost common lung %# to cause superior vena cava obstruction :ost common lung %# to cause %ushingKs syndrome and secretion of inappropriate antidiuretic hormone ((+#*&! C*inica* features :ost aggressive (trongest association with smoking .oorest survival /?A to 0@A of cancers Treated with chemotherapy Patho*o)ic features Large central mass Tumor necrosis Ra,io)ra'hic features #rises in association with pro$imal airways Lobar and main bronchi %entrally located tumor &ilar or perihilar mass :assive adenopathy, often bilateral Lobar collapse )areperipheral nodule 6! Lar)e.Ce** #n,ifferentiate, Carcinoma Characteristics 0A?A of lung cancers (trong association with cigarette smoking )apid growth 'arly metastases .oor prognosis Patho*o)ic features .eripheral Large, L ; cm Ra,io*o)ic features Large bulky peripheral mass 4ecrosis .leural involvement with effusion :ore aggressive and spread early .eripheral L ; cm Paraneo'*astic syn,romes associate, with -roncho)enic carcinoma &ypercalcemia 'ctopic adrenocorticotropic hormone production (yndrome of inappropriate secretion of antidiuretic hormone 'atonLambert syndrome (peripheral neuropathy with myasthenialike symptoms! #canthosis nigricans &ypertrophic osteoarthropathy 10 OTHER +ALIG"A"T T#+OR ! Carcinoi, Tumors Characteristics #rise from neuroendocrine cells Type /, typical carcinoid Type 0, atypical carcinoid Lowgrade malignancy in type / -ood prognosis C*inica* features :edium age ?@ :ales and females e7ually affected %ough, hemotysis )arely %ushingKs syndrome Patho*o)ic features (mall cells 4euroscretory granules #typical carcinoids .eripheral /@A of cases :etastasize in ;@A to ?@A of cases Ra,io)ra'hic features %entral F@A of cases Lobar, segmental, subsegmental bronchi ,bstructive pneumonia and atelectasis .eripheral 0@A of cases (low growth if typical Large and faster growth if atypical %alcification seen on %T %! Ho,)EinFs ,isease C*inica* features 5imodal agedistribution 6oung adults 'lderly men :ass in neck or groin (ystemic symptoms > M5K classification (urvival of 1?A stage / and ++ radiotherapy alone Ra,io)ra'hic features %T for staging F?A thoracic involvement :ultiple lymphnode groups #nterior mediastinum most common Lung involvement .rimarylung hdogkinKs rare 4odules,masses .erihilar %avitation #ir bronchograms <ollowup )ecurrence adjacent to radiation portal .ericardial nodes 11 :)+ *ifferentiates residual from recurrent tumor from fibrosis T0 weighed <ibrosis > low (+ Tumor > bright (+ 'ggshell calcification in nodes &! "on.Ho,)EinFs *ym'homa C*inica* features Low grade ,lder patients -eneralized lymphadenopathy #symptomatic +ntermediate and high grade 6ounger patients Treatment with aggressive chemotherapy +mmunocompromised hosts #+*( Transplant recipients N?@A intrathoracic involvement Ra,io*o)ic features (imilar to &odgkinKs disease %hestwall involvement :ore common *irect e$tension or primary site .leura *irect e$tension Localized pla7uelike seeding .leural effusionslymphatic obstruction Lung parenchyma .rimary e$tranodal site :ass with air bronchogram :ultiple masses or consolidation <ollow up Localized recurrence Eithin 0 years )adiation pneumonitis and fibrosis J to F weeks posttreatment %onforms to portal %onsolidation with air bronchograms <ibrosis Loss of volume Linear opacities Traction bronchiectasis 5! +etastatic ,isease G hemato)enous spread %T &igh sensitivity, low specificity, false positives owing to intraparenchymal lymph nodes, granulomas 5oth lungs, lower lobes .eriphery )ound, well marginated 9ariable doubling times %a GG .rimary bone and cartilage tumors :ucinous adenocarcimonas %avitation :etastatic s7uamous cell (olitary pulmonary nodule N/@A of cases 12 +f s7uamous cell, likely a lung primary 6! +etastatic ,isease. *ym'han)itic s'rea, Characteristics :ay result from hematogenous spread .rimary sites Lung 5reast 3pperabdominal malignancy :ore commonly bilateral Ra,io)ra'hic features %hest radiograph )eticulonadar pattern Berley 5 lines .leural effusion (J@A! #denopathy (0?A! &igh resolution %T 4odular thickening of bronchovascular bundles .olygonal arcades 5eaded septal thickening 8! +etastatic Disease G en,o-ronchia* metastases Site of 'rimary ma*i)nancy Bidney :elanoma Thyriod 5reast %olon Ra,io)ra'hic features #telectasis &ilar :ass 9! +etastatic ,isease G intrathoracic a,eno'athy Sites of 'rimary ma*i)nancy -enitourinary &ead and neck 5reast (kin (melanoma! Ra,io)ra'hic features #denopathy O parenchymal metastases Location of IC# tu-es: ! Ti' of the en,otrachea* tu-e tip should be about ; cm the tracheal carina %! Ti' of the naso)astric tu-e tip and sideport of the 4-T should be positioned distal to the esophagogastric junction and pro$imal to the gastric pylorus &! I,ea* 'osition of the chest tu-e chest tube placed to evacuate a pneumothora$ should ideally be placed with its tip in the nondependent part of the pleural space 13 chest tube placed to evacuate a pleural fluid should be positioned in a dependent portion of the pleural space 5! 0est 'osition of the centra* 4enous catheter used primarily to administer fluid and medication to provide vascular access for hemodialysis if pressure measurements are going to be obtained tip of the catheter must be pro$imal to the venous valves a well positioned central venous catheter projects over the silhouette of the superior vena cava, in zone demarcated superiorly by the anterior / st rib and clavicle and inferiorly by the top of the right atrium 6! Ti' of the Swan.Gan( catheter used to monitor pulmonary capillary wedge pressure to measure cardiac output in patients suspected of having left ventricular dysfunction tip should be positioned within the right or left main pulmonary arteries or in one of their large lobar branches 8! Intraaortic -a**on 'um' cardiac assist device positioned in the descending thoracic aorta via a femoral arterial approach a balloon on the catheter inflates during diastole, improving myocardial perfusion by increasing blood flow through the coronary arteriesP the balloon deflates during systole" tip of +#5. should be seen at the junction of the aortic arch and descending thoracic aorta, just distal to the origin of the left subclavian artery
Chronic O-structi4e Pu*monary Disease ! Em'hysema Patho*o)y %entrilobular (central lobule! .anlobular (entire lobular! .araseptial (distal lobule, subpeural! .aracicatricial (around scars! C*inica* features %igarette smoking *yspnea %hronic airflow obstruction (Q <'9/, R TL%, R )9, Q *L%,! Ra,io*o)ic features ,verinflation Low, flat diaphragm +ncreased retrosternal clear space Em'hysema as Seen on HRCT Centri*o-u*ar :ultiple small areas of low attenuation 4o walls 14 3pper lobes Pan*o-u*ar <ewer and smaller vessels Lower lobes Parase'ta* (ubpleural and along fissures Thin walls (ingle row Paracicatricia* 3sually focal #ssociated with scars %! Chronic 0ronchitis %linical and pathologic features %linical definition .athologymucousgland hyperplasia Ra,io)ra'hic features 4ormal Thickened bronchial walls 'ndon ring shadows Tram lines (in profile! ,verinflation &! Asthma %linical pathologic features )eversible bronchospasm Two thirds atopic #ctive inflammation of the airways Ra,io)ra'hic features 3ncomplicated 4ormal in majority (igns of hyperinflation 5ronchialwall thickening &)%T 5roncialwall thickening and mild dilation of bronchi Com'*icate, .neumonia Lobar or segmental atelectasis #llergic bronchopulmonary aspergillosis (#5.#! :ucoid impaction .neumomediastinum .neumothora$ 0RO"CHIECTASIS %auses of 5ronchiectasis Infection 9iral ()(9, adenovirus, mycoplasma! Tuberculosis %hronic or recurrent bacterial infections )ecurrent aspiration pneumonia Deficiency in host ,efense #gammaglobulinemia -ranulomatous disease of childhood A-norma*ities of carti*a)inous structure Eilliams%ampbell syndrome A-norma* mucus 'ro,uction %ystic fibrosis 15 A-norma* ci*iary c*earance *yskinetic cilia syndrome BartegenerKs syndrome 0ronchia* o-struction A**er)ic -roncho'u*monary as'er)i**osis =A0PA> "o:iou: fume inha*ation Pu*monary fi-rosis Traction bronchiectasis )adiation fibrosis (arcoidosis +diopathic pulmonary fibrosis C*assification of -roncheictasis ! Cy*in,rica* 5ronchi are minimally dilated, have straight regular outlines and end s7uarely and abruptly #verage number of bronchial divisions is /J microscopically (/10@ bronchial divisions normally! %! Haricose *ilation of bronchus with sites of relative construction, bulbous appearance #verage number of bronchial divisions: F &! Cystic or saccu*ar 5allooned appearance, airCfluid levels #verage number of bronchial divisions: ; Ra,io)ra'hic features of -ronchiectasis Thickwalled bronchus larger in diameter than accompanying pulmonary artery *ilated and thick walled bronchi in the periphery of the lung Cy*in,rica* -roncheictasis (mooth dilation of bronchus with lack of tapering HTramlinesI when seen on plane of scan H(ignet ringI when seen in cross section Haricose -ronchiectasis 5ulbous appearance of bronchus :ay mimic cylindrical broncheictasis in cross section Cystic -roncheictasis (tring or cluster of cysts with discernable walls #irCfluid levels within cysts HRCT Air tra''in) refers to the abnormal retention of gas within the lung following e$piration" ,n &)%T, the lung parencyhma remains lucent on e$piration, while normal lung areas show increased attenuation" +nspiration scans can be completely normal in air trapping" #ir trapping therefore cannot be diagnosed on inspiration scansP lung inhomogeneity during inspiration scans can be interpreted as mosaic perfusion" Traction -ronchiectasis 16 refers to bronchial dilation that occurs in patients with lung fibrosis or distorted lung architecture" Traction on the bronchial walls due to fibrous tissue reults in irregular bronchial dilation (bronchiectasis!" 3sually segmental and subsegmental bronchi are involved, but small periperhal bronchi or bronchioles may also be affected" %ommonly associated with honeycombing Centri*o-u*ar no,u*es 4odules as small as /0 mm in diameter can be detected by &)%T" 4odules can be classified according to their appearance such as welldefined (likely interstitial! or illdefined (likely airspace! or classified according to their distribution in relation to other lung structures (i"e" perilymphatic, random, or centrilobular!" Ran,om*y ,istri-ute, no,u*es )andom nodules are usually welldefined and appear diffuse, but uniform in distribution" Peri*ym'hatic no,u*es .erilymphatic nodules are usually welldefined and occur in relation to the lymphatics" They often affect the pleural surfaces and the peribronchovascular, interlobular septa, and centrilobular interstitial components! P*eura* effusions Transudative pleural effusions are formed when normal hydrostatic and oncotic pressures are disrupted" '$udative pleural effusions occur when pleural membranes or vasculature are damaged or disrupted therefore leading to increased capillary permeability or decreased lymphatic drainage" Groun,.)*ass o'acity is a nonspecific term that refers to the presence of increased hazy opacity within the lungs that is not associated with obscured underlying vessels (obscured underlying vessels is known as consolidation!" +t can reflect minimal thickening of the septal or alveolar interstitium, thickening of alveolar walls, or the presense of cells or fluid filling the alveolar spaces" +n an acute setting, it can represent active disease such as pulmonary edema, pneumonia, or diffuse alveolar damage" Honeycom-in) suggests e$tensive lung fibrosis with alveolar destruction and can result in a cystic appearance on gross pathology" can be diagnosed via &)%T by the presence of thich walled, airfilled cysts, usually between the size of 3mm to /cm in diameter" Lym'ha,eno'athy 'nlargement of hilar or mediastinal lymph nodes can be symmetric or asymmetric" 17 +t can represent hematogenous metastasis, a primary carcinoma, or other pathology" +osaic 'erfusion 3 attenuation refers to areas of decreased attenuation which results from regional differences in lung perfusion secondary to airway disease or pulmonary vascular disease" *istribution is often patch, hence the designation Smosaic"S ,ften with mosaic perfusion, the pulmonary arteries will be reduced in size in the lucent lung fields thus allowing mosaic perfusion to be distinguished from groundglass opacity Inter*o-u*ar se'ta* thicEenin) is commonly seen in patients with interstitial lung disease" ,n &)%T, numerous clearly visible septal lines usually indicates the presence of some interstitial abnormality" (eptal thickening can be defined as being either smooth, nodular or irregular and each likely represents a different pathologic process" Tree.in.-u, appearance represents dilated and fluidfilled (i"e" pus, mucus, or inflammatory e$udate! centrilobular bronchioles" #bnormal StreeinbudS bronchioles can be distinguished from normal centrilobular bronchioles by their more irregular appearance, lack of tapering or knobbyCbulbous appearance at the tip of their branches" The StreeinbudS distribution is often patch throughout the lung" Patterns of O'acities in Infi*trati4e Lun) Disease "o,u*ar or reticu*ar no,u*ar 'attern =Sma** Roun,e, O'acities> (ilicosis %oal workerKs pneumoconiosis &ypersensitivity pneumonitis &istiocystosis T Lymphangitic carcinomatosis (arciodosis .ulmonary alveolar microlithiasis Linear Pattern =Sma** Irre)u*arI Reticu*ar O'acities> +diopathic pulmonary fibrosis (3+.! (+.<! %hronic interstitial pneumonias (*+., L+., 5+.! (arciodosis )adiotion fibrosis <ibrosis associated with collagen vascular disease #sbestosis *rug reactions 18 Lymphangitic carcinomatosis Cystic Pattern +.< (honeycombing! Lymphangioleiomyomatosis &istiocytosis T Groun,.G*ass Attenuation &ypersensitivity pneumonitis *+., +.< #lveolar proteinosis Parenchyma* conso*i,ation =air.s'ace or a*4eo*ar ,isease> 5ronchiolitis obliterans organizing pneumonia %hronic eosinophilic pneumonia 5ronchioloalveolar carcinoma Lymphoma #lveolar proteinosis 9asculitis .ulmonary hemorrhage Se'ta* Lines Lymphangitic carcinomatosis %&< > interstitial edema $ona* Preference #''er $ones (ilicosis %oal workerKs pneumoconiosis (arcoidosis #nkylosing spondylitis &istiocytosis T Lower $ones %hronic interstitial pneumonias +.< #sbestosis <ibrosis due to collagen vascular disease Centra* .ulmonary edema .ulmonary alveolar proteinosis (ome lymphangitic tumors (BaposiKs! Peri'hera* %hronic interstitial pneumonias, +.< 5ronchiolitis obliteransorganizing pneumonia %hronic eosinophilic pneumonia P*eura* Disease .neumothora$ &istiocytosis T 'ndstage honeycombing P*eura* Effusion Lymphangioleiomyomatosis %ollagen vascular disease Lymphangitic carcinomatosis .ulmonary edema P*eura* ThicEenin) 19 #sbestosis (pla7ues or diffuse! %ollagen vascular disease Lun) Ho*umes Re,uce, +diopathic pulmonary fibrosis %hronic interstitial pneumonias #sbestosis %ollagen vascular disease "orma* (arcoidosis &istiocytosis Increase, lymphangioleoiomyomatosis Hi)h.reso*ution CT.Linear O'acities Thickening of bronchovascular bundles (a$ial! +nterlobular septal thickening (septal lines! +ntralobular interstitial thickening &oneycombing (ubpleural lines %entrilobular abnormalities :'*+#(T+43:: ! Anterior +e,iastinum 0oun,aries anteriorly by the sternum posteriorly by the anterior margins of the pericardium, aorta, and brachiocephalic vessels "orma* structures Thymus gland Lymph nodes <at +nternal mammary vessel Differentia* ,ia)nosis of anterior me,iastina* masses Thymoma Lymphoma -erm cell neoplasms Thyroid abnormalities %! +i,,*e +e,iastinum 0oun,aries 5y posterior margin of anterior division and anterior margin of posterior division "orma* structures &eart and pericardium #scending and transverse aorta 5rachiocephalic vessels (9% and +9% :ain pulmonary vessel Trachea and main bronchi Lymph nodes <at Differentia* ,ia)nosis of mi,,*e me,iastina* masses Lymphanedopathy 5ronchogenic cyst 9ascular abnormalities .ericardial cyst 20 Tracheal tumor &! Posterior +e,iastinum 0oun,aries 5ounded anteriorly by the posterior margins of the pericardium and great vessels and posteriorly by the thoracic vertebral bodies "orma* structures *escending thoracic aorta 'sophagus Thoracic duct #zygousChemiazygous #utonomic nerves Lymph nodes <at Differentia* ,ia)nosis of 'osterior me,iastina* masses 4eurogenic tumors .aravertebral abnormalities 9ascular abnormalities 'sophageal abnormalities Lymphadenopathy 4eurenteric cyst 5ochdalek hernia '$tramedullary hematopoeisis Thymoma Demo)ra'hics A)e 3sually ;@J@P unusal in patients less than 3@ Gen,er :ale and females e7ually #ssociations :yasthenia gravis, hypogammaglobulinemia, red cell aplasia Descri'ti4e features Thymoma =nonin4asi4e> Eelldefined, round, soft tissue, density mass, usually located anterior to the junction of the heart and great vessels %urvilinear calcification in 0@A In4asi4e thymoma #dditional findings of invasion of adjacent mediastinal structures, chest wall invasion, or contiguous spread along pleural surfaces (usually unilaterally! Ho,)EinFs *ym'homa Demo)ra'hics A)e 5imodal distribution, with initial peak in young adults and second peak after age ?@ Gen,er 21 :ale predominance, especially among youngest patients Descri'ti4e features 9ariable appearance, ranging from a single spherical soft tissue mass to a large lobulated mass :argins may be welldefined or irregular The mass may be homogenous or heterogenous soft tissue attenuation %alcification is rare in untreated cases Germ.ce** neo'*asms Demo)ra'hics A)e 6oung patients, usually third decade Gen,er :alignant germ cell neoplasms >male predominance Descri'ti4e features 0eni)n GC" =TeratomaI Dermoi, Cyst> &eterogenous, predominantly cystic mass with solid components Eelldefined margins %alcification common .resence of fat is suggestiveP identification of a tooth, while rare, is diagnostic +a*i)nant GC"=seminomaI choriocarcinomaI Em-ryona* ce** carcinomaI Yo*E sac tumor> &eterogenous solid mass +rregular margins %alcification uncommon Thyroi, +asses Demo)ra'hics A)e > usually L3@ years of age Gen,er female predominance Descri'ti4e features CJR features Eelldefined mass that e$tends from above the thoracic inlet *isplacement andCor compression of the trachea <oci of calcification may occasionally be visible CT features %ontinuity with the cervical thyroid gland <oci of high attenuation on noncontrast images +ntense enhancement following intravenous contrast administration %ystic areas and foci of calcification are common 0roncho)enic Cyst Demo)ra'hics #ge > often seen on younger patients but may be detected at any age -ender > males and females e7ually Descri'ti4e features (ubcarinal or right paratracheal location Eelldefined homogenous mass with imperceptible walls <luid or softtissue attenuation on %T 9ariable appearance on :)+, depending on cyst contents low signal on T/ and bright on T0 or 22 bright signal or T/ and bright on T0 (if cyst contains mucin, protein or hemorrhage "euro)enic tumors Demo)ra'hics #ge usually occur in younger patients first ; decades of life -ender males and females e7ually affected Descri'ti4e features "er4e sheath tumors )ound, homogenous, paraspinal mass :ay be associated with widening of the neural foramen :)+: slightly brighter than muscle on T/ and very bright on T0 homoegenous enhancement following gadolinium administration Sym'athetic chain tumors <usiforms, homogenous parspinal mass :ay be associated with vertebral body erosion :) characteristics similar to those of nerve sheath tumor .L'3)# )adiologic featuers of pneumothora$ (tandard radiographs 9isceral pleural line separated from chest wall by gas space devoid of vessels #pe$ when upright Lung opa7ue only with complete collapse Tension :ediastinal shift *epression of hemidiaphragm (upine :edial recessju$tacardiac *eep sulcus sign (ubpulmonic )etrocardiac lucent triangle medially #ncillary views '$piratory *ecubitus .itfalls (kinfolds %lothing Tubing artifacts 5ullae %T 23 :ore sensitive in detection of small pneunothoraces :ore accurate in determining size :alignant :esothelioma %linical features )are > 0@@@ to 3@@@ cases per year F@A history of asbestos e$posure 3@ to ;@ year latency J th to F th decades of life :en more than women > ;:/ (ymptoms %hest pain *yspneaP weight loss .athologic features Types 'pithelial (?@A! (arcomatous :i$ed -ross fetures 'ncasement of lung -rowth of tumor into lung, chest wall, mediastinum, diaphragm )adiologic features (tandard radiographs *iffuse pleural thickening 4odular 'ncases lung .leural effusion .leural mass *ecrease in size of hemithora$, shift of mediastinum to affected side .la7ues %T (taging '$tent %hest wall, mediastinal diaphragmatic invasion :) +mproved staging .leural metastases ,rigins Lung 5reast ,vary (tomach Lymphoma :anifestation :aligant effusion *iffuse thickening <ocal seeding BENIGN VS MALIGNANT NODULE Benign M!ignn" S#$e %&'n( i))eg'!) Si*e + 3 ,- . 3 ,- S$i,'!"i&n /0en" $)e0en" M)gin0 1e!! (e2ine( i!! (e2ine( 24 3!,i2i,"i&n $)e0en" /0en" 34i""i&n /0en" $)e0en" D&'/!ing "i-e + 1 -& &) . 2 5)0 . 1 -& &) + 2 5)0 MEDIASTINAL VS PULMONARY MASS MEDIASTINAL MASS PULMONARY MASS E$i,en"e) in "#e -e(i0"in'- E$i,en"e) in !'ng O/"'0e ng!e 16 "#e !'ng A,'"e ng!e 16 "#e !'ng 7-8 i) /)&n,#&g)- 798 i) /)&,#&g)- S-&&"# n( 0#)$ -)gin0 I))eg'!) -)gin0 M&4e-en" 16 01!!&1ing M&4e-en" 16 )e0$i)"i&n Bi!"e)! 'ni!"e)! )adiologic signs /" air bronchogramUindicates a parenchymal process, including nonobstructive atelectasis, as distinguished from pleural or mediastinal processes 0! deep sulcus sign on a supine radiographUindicates pneumothora$ 3" -olden ( sign indicates lobar collapse caused by a central mass, suggesting an obstructing bronchogenic carcinoma in an adult ;" &tonKs humpUpleuralbased, wedgeshaped opacity indicating a pulmonary infarct ?" silhouette signUloss of the contour of the heart, aorta or diaphragm allowing localization of a parenchymal process (eg, a process involving the medial segment of the right middle lobe obscures the right heart border, a lingular process obscures the left heart border, a basilar segmental lower lobe process obscures the diaphragm! 25