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DASH and Mean SBP Change Other Findings Related to DASH & BP
In DASH-sodium trial, DASH lowered BP at all
134
Control levels of sodium intake but DASH + low
Fruit & Veg
132 DASH
sodium led to greatest reductions in BP
130
(Sacks F, N Engl J Med 2001)
African-Americans particularly vulnerable to
SBP (mmHg)
128
126 adverse BP effects of low potassium diet
124 (Morris RC, Hypertension 1999)
122
In IWHS, concordance with DASH (using
120
0 1 2 3 4 5 6 7 8
score) was not associated with lower risk of Htn
Follow-up Time (wks) (Folsom AR, AJH 2007)
WHI emphasizing fruits, veg & whole grains led
• Effects in African-Americans were nearly double those of Caucasians to modest reductions in SBP & DBP
(Howard BV, JAMA 2006)
7 Appel L. N Engl J Med 1997;336:1117-1124 8
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• In setting of MetS,
Baseline intakes key nutrients higher in some
Mean Change in SBP (mmHg)
-2.0
DASH diet enhanced
-4.0 beneficial effect of EST subsequent studies so effects may be weaker.
-6.0 intervention
-8.0 -6.8
-6.2 WHI did not emphasize dairy intake. Review
• In those without MetS,
-10.0
-8.4
the EST intervention &
(Kris-Etherton) concludes: there is growing
-12.0
-9.8
-11.2
EST + DASH were evidence that dairy is involved in BP regulation.
-12 equally effective
Advice only
-14.0
Met. Syndrome No Met. Syndrome EST DASH scoring systems equally weight all dietary
EST+DASH
components and may wash out important
No added benefit of DASH compared with EST alone for lipids, insulin resistance or glucose
dietary effects.
9 Lien LF et al. Hypertension 2007;50:609-616 10
-5 Change in BMI
-6
-7
-8 Change in DBP
-9 DASH
-10
-11 Change in SBP Routine Care
-12
End of Rx 3-mo. f/u End of Rx 3-mo. f/u End of Rx 3-mo. f/u
Post-treatment completers 3-Month follow-up completers
DASH = 24; RC = 22 DASH = 18; RC = 18
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10/22/2009
DASH Eating Pattern in Young Children DASH Eating Pattern in Young Children
and Early Adolescent SBP and Early Adolescent DBP
60
116
114
FV / Dairy Intake
58 FV / Dairy Intake
Low / Low
110 High / Low
56 High / Low
High / High
108 Low / High
High / High
106 54
104
52
102
100
Preschool Diet Elementary Age 50
Preschool Diet Elementary Age
64
105 63
62
104
61
9-10 11-12 13-14 15-16 17-18 19-20 60
59
9-10 11-12 13-14 15-16 17-18 19-20
• Both higher dairy groups had lower
SBPs than those with lower dairy intake
Models are adjusted for ages, SES, race, activity, TV & height.
15
Data from National Growth & Health Study
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28 25
26
23
BMI (kg/m )
BMI (kg/m2 )
2
24
Adjusted for age, height, SES, race, activity, & TV watching Adjusted for age, height, race, socioeconomic status, activity level & tv/video hrs/day.
17 18 (NGHS)
NGHS Data
Adolescent Girls
78
W aist Circum ference (cm)
76
74
72
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10/22/2009
Comparing DASH vs. Fruits/Veg. Diet Does the Effect of DASH on Lipids
Alone on Changes in Lipid Levels Differ by Presence of Inflammation?
10 Total Cholesterol 10
LDL Cholesterol
DASH Eating Pattern and LDL in DASH Eating Pattern and HDL in
Adolescent Girls Adolescent Girls
DA<2.5, FV<3 svgs/day 58
106
104 DA<2.5, FV>=3 svgs/day 57
DA>=2.5, FV<3 svgs/day
102 56
LDL (mg/dL)
100 55
98 54
96 53
94 DA<2.5, FV<3 svgs/day
52 DA<2.5, FV >=svgs/day
92
51 DA>=2.5+, FV<3 svgs/day
90
DA>=2.5, FV>=3 svgs/day
50
9-10 11-12 13-14 15-16 17-21
Age (years)
9-10 11-12 13-14 15-16 17-20
Age (years)
NGHS
Adjusted for age, height, SES, race, activity, & TV watching Adjusted for age, height, SES, race, activity, & TV watching
23 24
NGHS
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10/22/2009
2.70
2.50
2.30
2.10
1.90
1.70
1.50
Baseline 6 Months
Time
After adjusting for baseline differences, DASH group had 35% greater increase in
insulin sensitivity.
Ard et al. Diabetes Care 2004;27:340-347
26
1.00
0.80
0.60
0.40
0.20
0.00
All Whites Blacks/Hispanics
Adjusted for age, sex, education level, race/ethnicity, glucose tolerance, family hx diabetes,
smoking, energy intake, energy expenditure, BMI, insulin sensitivity, and insulin secretion
Limitations: (a) use of single FFQ, (b) scoring system for DASH DASH: high in calcium, potassium, mg, vitamin C, protein
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20
CTX, Control DASH scoring systems show varying results in epi. studies
(which may reflect limitations of scoring system). Not know
% Change
10
whether some components should be weighted more heavily.
0
DASH eating pattern, especially when combined with other
-10 lifestyle changes, has beneficial effects on body composition
-20 Race-specific effects need further study.
-30
DASH plan likely to reduce risk of developing Htn, CVD,
Baseline Period 1 Period 2 Period 3
CTX = C-terminal telopeptide of type 1 collagen Each sodium period = 30 days
osteoporosis and perhaps diabetes and CHF.
OC = osteocalcin 3 sodium intake levels: 50, 100, 150 mmol/d
8
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9
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10
10
5
5
16% 13%
0
0 0 1 2 3 4 5 6 7 8 9
0 1 2 3 4 5 6 7 8 9
DASH Score
DASH Score
10