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1. Blood pressure lowering and stroke............................................................................................................. 1
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Blood pressure lowering and stroke
Author: Saini, Monica; Shuaib, Ashfaq

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Abstract: Hypertension is the most prevalent of the modifiable risk factors for stroke. The benefits of blood
pressure (BP) lowering on primary and secondary prevention of stroke are undeniable. Despite this, BP control
in hypertensive individuals and patients with prior cerebrovascular events is suboptimal. Noncompliance,
inappropriate antihypertensive usage and under-utilization of medications contribute significantly to inadequate
BP control. Recently, elegantly designed studies that assessed the preventive role of BP lowering in patients
with cerebrovascular disease have helped clarify management issues in terms of BP targets and effective
antihypertensive regimens. Current evidence suggests that BP targets for primary and secondary prevention
are suboptimal and need reassessment. The effect of BP modulation in acute stroke is still not completely
understood. Although the thresholds for BP treatment in acute stroke have been recommended, BP targets are
as yet ill-defined. The available evidence supports early lowering of blood pressure following stroke. This review
discusses the impact of blood pressure on stroke incidence and outcomes, outlines the recommendations for
blood pressure lowering in stroke and delineates questions that still need to be addressed.
MeSH: Blood Pressure -- drug effects, Clinical Trials as Topic, Humans, Hypertension -- drug therapy, Stroke --
drug therapy, Antihypertensive Agents -- therapeutic use (major), Blood Pressure -- physiology (major),
Hypertension -- complications (major), Stroke -- etiology (major), Stroke -- prevention & control (major)
Substance: Antihypertensive Agents;

Publication title: Expert Review of Neurotherapeutics
Volume: 10
Issue: 2
Pages: 225-41
Publication year: 2010
Publication date: Feb 2010
Year: 2010
Publisher: Informa Healthcare, Expert Reviews Ltd.
Place of publication: London
Country of publication: United Kingdom
Publication subject: Pharmacy And Pharmacology, Medical Sciences--Psychiatry And Neurology
ISSN: 1473-7175
Source type: Scholarly Journals
Language of publication: English
Document type: Review, Journal Article
DOI: http://dx.doi.org/10.1586/ern.09.162
Accession number: 20136379
13 May 2014 Page 1 of 2 ProQuest
ProQuest document ID: 198267850
Document URL: http://search.proquest.com/docview/198267850?accountid=50673
Copyright: 2010 Expert Reviews Ltd
Last updated: 2014-03-24
Database: ProQuest Medical Library,ProQuest Psychology Journals
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