Safety leukoSTAT™ ( ImSAIDs® Enabled) .

The ImSAIDs® are comprised of natural leukoSTAT™ contains the ImSAIDs®;

amino acids that have demonstrated no
toxicity or immune suppression in numerous
animal studies, including dogs, cats, and a
variety of other species
ImSAIDs® - Cellular Modulation
in vivo and in vitro results have shown the
ImSAIDs® to help support the following:
reduce granulocyte activation and
chemotaxis
diminish oxidative burst capacity and the
production of reactive oxygen species
attenuate the effects of endotoxin, and
reduce allergic & anaphylactic reactions
(type I hypersensitivity and IgE-mediated
reactions)
patented amino acid complexes that
maintain systemic health, by aiding in the
reduction of leukocyte activation and
chemotaxis. ImSAIDs® are Not COX/LOX
inhibitors or steroids, but naturally
occuring amino acid complexes that nature
designed to positively influence the
Immuno-Nutritional
immune system, including leukocytes. Technology
leukoSTAT™ Product & Ordering
IMULAN has developed a highly palatable,
ALL Inflammation is Regulated
chewable tablet for dogs and cats. The by Leukocytes
small, 625mg chewable tablet can be used
when only small amounts of material can
be given orally. leukoSTAT™ is available in
30 and 120 count bottles.

Additional References on ImSAIDs® To purchase LeukoSTAT™; please go to

Immunopharmacology www.IMULAN.com and set up an account.
Mathison R, et al. Modulation of neutrophil function by the
tripeptide feG. BMC Immunol. 2003 Mar 4;4:3. 2003
You may also contact IMULAN at
Mathison R, et al. Regulation of leukocyte adhesion to heart by the info@ imulan.com
tripeptides feG and feG(NH2). Can J Physiol Pharmacol. 2001 Sep;
79(9):785-92.
Mathison RD and Davison JS. The Tripeptide feG Regulates the
Production of Intracellular Reactive Oxygen Species by Neutrophils. J
Inflamm (Lond). 2006 Jun 15;3(1):9 IMULAN BioTherapeutics
Mathison R, Davison JS, Befus AD. Neuroendocrine regulation of
inflammation and tissue repair by submandibular gland factors.
Immunol Today.1994 Nov;15(11):527-32.
4221 Mitchell Avenue
Mathison RD, et al. The tripeptide feG inhibits leukocyte adhesion. J
Inflamm (Lond). 2008 May 20;5:6.
St. Joseph, MO 64507
Mathison R, Davison JS. Molecular characteristics of the tripeptide
feG accounting for different biological activities. Proc West www.IMULAN.com
Pharmacol Soc. 2007;50:101-4.
Mathison RD, et al.. A peptide from the submandibular glands 480-248-2176
modulates inflammatory responses. Int Arch Allergy Immunol. 1997
May-Jul;113(1-3):337-8.
Mathison RD, et al. Submandibular glands: novel structures
participating in thermoregulatory responses. Can J Physiol
Pharmacol. 1997 May; 75(5):407-13.
ImSAIDs® Key Benefits Acute pancreatitis Anaphylaxis
The ImSAIDs® (Immune Selective Anti- 35
Neutrophil inhibition after after intestinal

Neutrophil count, mean ± sem, n=5

anaphylaxis
Inflammatory Derivatives) are a brand new 8
30
7

Lipase Units x 103/mL

Sensitized control
amino acid technology designed by Mother 6 25 ImSAID treated
Nature. The ImSAIDs® are naturally occuring 5 Dexamethasone
20
amino acid complexes that nature designed 4 *
*
15
to help reduce over activation of the immune 3
2 10
response. 1
5
0
Critical Care Medicine Models Normal, no
pancreatitis
No treatment ImSAIDs
(0hr)
ImSAIDs
(3hr)
0
0.5 3 24
The ImSAIDs have been evaluated in a variety Hours after challenge

of comparative disease models of sepsis, Pancreatitis Model Allergic/Anaphylaxis/IgE mediated Model

Rifai Y, et al. The tripeptide analog feG ameliorates severity of Turesin F, et al.: The tripeptide FEG ameliorates systemic
endotoxemia, spinal trauma, pancreatitis, acute pancreatitis in a caerulein mouse model. Am J Physiol inflammatory responses to rat intestinal anaphylaxis. BMC Physiol
asthma, allergic and anaphylactic reactions. Gastrointest Liver Physiol.2008 Apr;294(4):G1094-9. 2002, 2:13
The following are models using one ImSAID® CONTROL; severe cellular infiltration (lung)
amino acid complex, phe-glu-gly, or feG.

Chemotaxis, adhesion

Inhibition of neutrophil chemotaxis

units MPO/mg tissue, mean ± sem, n=6

0.3

0.25

0.2
ImSAIDs (1mg/kg); mild cellular infiltration
0.15

0.1

0.05
0 0.35 1 3.5 10 100
ImSAID dosage, µg/kg
Neurological Trauma Model
Endotoxin/Sepsis Model Bao F, et al. The tripeptide phenylalanine-(D) glutamate-(D)
Tan D, et al. The carboxamide feG(NH2) inhibits endotoxin glycine modulates leukocyte infiltration and oxidative damage in
perturbation of intestinal motility. Eur J Pharmacol. 2000 Dec rat injured spinal cord. Neuroscience. 2006 Jul 7;140(3):1011-22.
Inflammation/Asthma Model
8;409(2):203-5. John SM, Bao F, Chen Y, Mathison RD, Weaver LC.Effects of a
Dery RE, et al. Frontline: Inhibition of allergen-induced pulmonary
Mathison R, et al. The tripeptide feG reduces endotoxin-provoked novel tripeptide on neurological outcomes after spinal cord
inflammation by the tripeptide feG: a mimetic of a neuro-endocrine
perturbation of intestinal motility and inflammation. injury. Neuroreport. 2006 Nov 27;17(17):1793-6.
pathway. Eur J Immunol. 2004 Dec;34(12):3315-25.
Neurogastroentero Motil. 2001 Dec;13(6):599-603.