Ryan Demeter, Matt Jackson, Caroline Schulman, and Matt Whitfield NCIIA Project Pro osal

Project Pro osal for Non!"ranscranial #lectroanesthesia De$ice %rou &

Project description: Due to a rehension a'out the lon( term effects of assin( electrical current across the 'rain, $oiced 'y the )ood and Dru( Administration, an alternati$e method for administerin( electroanesthesia must 'e de$elo ed to 'rin( electroanesthesia to market in the *nited States +)ries &,,-./ #lectroanesthesia, in its resent form, 'oasts many 'iolo(ical 'enefits o$er (as and li0uid anesthesia1 an alternati$e non!transcranial, ossi'ly $a(al ner$e stimulation, method may also ha$e these 'iolo(ical 'enefits/ 2y utili3in( the $a(al ner$e, a theoretical method for a lication of electroanesthesia may 'e ro osed/ 4a(al ner$e stimulation +4NS. offers the anal(esia as ect of anesthesia accordin( to research/ "hrou(h the de$elo ment and further research into 4NS, full anesthesia may 'e de$elo ed/ "here are fe5er side effects 5ith electroanesthesia due to these 'iolo(ical 'enefits, and non!transcranial electroanesthesia may also 'oast these 'enefits +Sances and 6arson and 6arson 789-./ "he main focus of the desi(n rocess for this roject is to de$elo an a licator and control de$ice for electroanesthesia/ :ur de$ice 5ill control and administration electroanesthesia and roduce di(ital atient records/ "he de$ice 5ill 'e orta'le, self sustainin(, and rechar(ea'le/ "his re0uires utili3in( a mini!PC to run 6a'4ie5 on 'oot, recei$e in ut + atient and other medical information. $ia a *S2 key and control electrical out ut arameters/ "he *S2 key 5ill store atient information and the rocedure history for atient records/

Ryan Demeter, Matt Jackson, Caroline Schulman, and Matt Whitfield NCIIA Project Pro osal Market Potential "he market otential for a non!transcranial electroanesthesia de$ice encom asses medical rocedures 5here li0uid and (as anesthesia are utili3ed for sur(ery 'elo5 the neck/ Accordin( to As ect Medical Systems o$er an estimated &, million eo le under(o sur(ery usin( (eneral anesthesia each year in the *nited States/ A non!transcranial electroanesthesia de$ice 5ould re lace current (as and li0uid anesthesia a aratuses/ In less de$elo ed countries the hi(h cost of anesthesia and lack of medical e; ertise make anesthesia hard to administer/ An electroanesthesia de$ice 5ould reduce the cost of anesthesia and the need for an anesthesiolo(ist/ In de$elo ed countries 5ere ad$anced anesthesia de$ices are used, an electroanesthesia de$ice 5ould reduce the de endence of (as and li0uid anesthesia/ "here is nothin( on the market in the *S similar to the ro osed de$ice1 there are electroanesthesia de$ices in #uro e that utili3e transcranial methods +"akakura./ Social impact: #lectroanesthesia 'oasts many ad$anta(es o$er (as and li0uid anesthesia such as, a 0uicker reco$ery time and less 'iolo(ical effect durin( and after sur(ery +Photiades, &7<!&&-./ Patients heal 'etter 5hen anestheti3ed 5ith electroanesthesia and are less affected 'y the rocess +Sances and 6arson, &7!&9./ Accordin( to research done in #uro e there is no harmful effect on electrocardio(rams +#C%. or electroence halo(rams +##%./ In mammalian testin( there 5as a chan(e in the ##% +Sances and 6arson, --!-<. 'ut little on #C% and little neural tissue chan(e/ =ammond et al/ +788&. states that in human testin( there is o'$ious chan(e in scal recordin( of ##% 5ith 4NS/

Ryan Demeter, Matt Jackson, Caroline Schulman, and Matt Whitfield NCIIA Project Pro osal )urthermore the e;tracellular and intracellular fluid of the 'rain sho5ed little chan(e in otassium and sodium concentration le$els 5ith electroanesthesia +Sances and 6arson, 7><!79-./ "hese electrolytes are im ortant to the function of many systems, homeostasis, and iron re(ulation in the 'ody and lay a role in ner$e stimulation/ "his electrolyte concentration sta'ili3ation differs from research data for li0uid anesthesia 5here electrolyte le$els are decreased due to chan(es 'y the chemical a(ents +Sances and 6arson, 7><!79-./ #lectroanesthesia also yields decreased (astric acid secretion +Sances and 6arson, ??!>@., leadin( to less of a chance for stomach ulcers seen 5ith other anesthesia/ E-team members and personal skills: Name Skills Ryan "homas 6a'4ie5, AutoCAD Demeter Matthe5 Wesley Microsoft :ffice, Jackson Matla', 6a'4ie5 Caroline Schulman Circuitry, NI #64IS Matthe5 James Matla', Microsoft Whitfield :ffice, 4isual 2asic Advisor: )irst NameA 6ast NameA =onorificA Position (job title)A De artmentA InstitutionA AddressA CityA StateA
121 21st ave south! "1#$ Me%ical &enter 'ast nashville Professor/Division Director Anesthesiology Multi-Specialty Div. James Berry

Education 2iomedical #n(ineerin( 2iomedical #n(ineerin( 2iomedical and #lectrical #n(ineerin( 2iomedical #n(ineerin(

Ryan Demeter, Matt Jackson, Caroline Schulman, and Matt Whitfield NCIIA Project Pro osal Bi CodeA #!mailA "ele honeA
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)ames.*erry+,an%er*ilt.'%u -1 -."--12#-

)a;A @7-!8?@!@>8? Proposed timeline/ goals Description 6ook into re$ious research done on 4NS and #lectroanesthesia/ No$em'er &,,- De$elo schematics and ossi'le de$ice hysical desi(ns/ Start desi(n de$elo ment/ Proceed 5ith research and finali3e our desi(n a roach/ Assem'le 'asic Decem'er &,,- desi(n com onents/ De$elo soft5are and user interface/ :'tain IR2 a ro$al to test our de$ice as early as ossi'le/ January &,,@ 2e(in desi(nin( rototy e model and testin(/ )e'ruary &,,@ Proceed 5ith rototy e desi(n and testin(/ Run e; eriments if a ro$ed and make modifications 5here necessary/ March &,,@ Continue 5ork!u and finali3e desi(n/ A ril &,,@ Continue to finali3e desi(n and re are a er and resentation oster/ esources: 6a' s ace ro$ided 'y 4ander'ilt *ni$ersity Protot!pe "udget:

Month

Mini PC +#$%&'()*+. o Pur oseA data rocessin(, soft5are e;ecution, and com onent control and interface/
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E,go E+&-* .unior - Color Silver - Processor Intel Celeron 2.4 GHz, 400MHz FSB - Me or! "#2MB $$% S&$IMM - H'r( $rive 20GB )oteboo* H'r( $rive - &+tic'l $rive 24, Sli C$-%&M $rive - &+er'tin- S!ste Microso.t /in(o0s ,P Pro /1SP2 - 2e!bo'r( 3 Mo4se /ireless 2e!bo'r( 3 Mo4se - /ireless 5SB 2.0 /ireless 6('+ter (e7tern'l) - Monitor (none) - 87ten(e( /'rr'nt! Incl4(e( - # 9e'r /'rr'nt!, P'rts 3 :'bor

Ca'les and rele$ant hard5are +C&&@-. o Connection ca'les +C9-.

Ryan Demeter, Matt Jackson, Caroline Schulman, and Matt Whitfield NCIIA Project Pro osal *S2 hu' and ca'les DAD ca'le connector o 2o; and mountin(s +C7-,. Case +DimensionsA "2D. )oam Mountin( =ard5are Mountin( DAD controller +C7?,,. National Instruments or Com ara'le *S2 key +C7,,. CD Cyclone &-@ M2 )lash Eey *S2 Pen Dri$e Stora(e De$ice Rechar(ea'le 2attery +C&,,. #;ternal Po5er =ook!u +C7,,. Canon 2JC!<, Porta'le Printer +C7-,. F&%en 7-G Monitor +C78,. #; erimentation +C7?-.
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De$ice "estin( #lectroanesthesia testin(

Miscellaneous +C7-,.
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*nforeseen costs Minor #; enses C?@7-/?9

"otal Cost Device /esting Phase I !De$ice com onents connected and tested to assure com ati'ility !Soft5are inte(rated and tested to assure com ati'ility and ro er o eration !"est in uts and out uts of de$ice Phase II !A licator testin( to assure ro er out uts and o eration Phase III ! "estin( of de$ice o eration 5ith a rat e0erencesA HAnethesia PAteint InformationH/ As ect Medical Systems/ Accessed 77I7>I,-/ Jhtt AII555/as ectmedical/comI atientsIinformationIdefault/ms ;K

Ryan Demeter, Matt Jackson, Caroline Schulman, and Matt Whitfield NCIIA Project Pro osal )ries, Richard/ #!mail inter$ie5/ - &,,-/ =ammond , #J, 2M *thman, SA Reid, and 2J Wilder/ H#lectro hysiolo(ical studies of cer$ical $a(us ner$e stimulation in humansA I/ ##% effects//H # ile sia/ ?? +788&.A 7,7?!7,&, Photiades, Dimitri P/, Janus %ar5acki, E/C/ Whittaker, and Andeas S/ 6am'is/ H#lectroaneasthesia in Major Sur(ery /H "he West African Medical Journal +:cto'er 78@?.A &7<!&&-/ Sances Jr/, Anthony, and Sanford J/ 6arson/ #lectroanesthesia 2iomedical and 2io hysical Studies/ Ne5 LorkA Academic Press, Inc/, 789-/ "akakura, Eintomo/ M"ranscutaneous #lectrical Ner$e Stimulation for Relie$in( PainA Physiolo(ical si(nificance of the 7If fre0uency fluctuation/G Accessed 77I>I,Jhtt AII555/e$er'est/com/auI"#NSforRelie$in(Pain7ffre0uencyfluctuation/html/K