A method of choice for processing of physically or chemically moisture sensitive drugs, as no liquid binder is required in the granulation.

This is suitable for compounds that either have a low melting point or degrade rapidly during heating, as the method does not involve any drying step. RCDG is useful technique for processing of drugs having low and inconsistent bulk and tap densities with very fine and inconsistent particle sizes and/or poor flow properties and poor compatibility. RCDG leads to minimized batch to batch variation with improved product quality due online control and automation of processing settings. The process potentially more easily scalable and may be able to reduce development time due to continuous processing with high productivity and less energy consumpti0n. Greatly utilized for the controlled-release tablets because particle size, one of the crucial factors determining the drug release behavior of matrix tablets, can be more easily targeted and controlled in roll compaction than in wet granulation, thanks to the process simplicity.

Roll compaction involves many process parameters: roll pressure, roll speed, horizontal/vertical feed screw speed, roller gap, screen size. But of all these parameters, the key parameters that would majorly control the critical properties of the compacted ribbon which in turn control the granules properties such as granules size, granules properties on which the final properties such as tablet strength, disintegration of table depend would be: Compaction force /roll pressure Roll speed/dwell time Screw Speed

The roller speed and compaction force has largest effect on the granule properties followed by the screw speed. This because for the screw speed parameter, whether high speed or low speed in both the cases if going to effect the ribbon quality and it is going to greatly depend on the roller speed. The compaction force should be such that the roll pressure applied would create the interpartticle bonds in the ribbon strong enough such that fractures form and leads to the granules rather than loosely compacted ribbon forming fine powders. Usually, higher compact force with the lower roll speeds lead to strong ribbon strength which leads to large granules and improved flowability. Larges granules form porous tablets thus allowing water to penetrate more easily into the tablet. This leads to improved disintegration behaviour of tablets. But then at the same time, for the plastic deformed material such as MCC, lower roller speeds leads to loss of compactibility and which causes to form the table with low tensile strength. While for the elastic material high roller speed will lead to weak ribbon strength and the brittle material is independent of the roller speed. On other hand, high roller speed with low compaction forces leads to smaller granules and high tablet strength. Tables from smaller granules will have a better dissolution profile due to increased surface area. But then, smaller granules will greatly decrease the flow properties of the granules. Thus, it can be concluded that limiting the compaction force to the degree that achieves the desirable granule property and selection of roller speed highly depend on the type of the material and it becomes critical to maintain the ratio of the roller speed to screw speed constant so that the ribbon strength is independent of the roller speed.