Contents

Volume 68 Issue 7 | THORAX July 2013

Editorials
603 Pirfenidone should be prescribed for patients with idiopathic pulmonary brosis
G Jenkins

Cystic brosis
643
OPEN ACCESS

Prospective evaluation of respiratory exacerbations in children with cystic brosis from newborn screening to 5 years of age
C A Byrnes, S Vidmar, J L Cheney, J B Carlin, D S Armstrong, P J Cooper, K Grimwood, M Moodie, C F Robertson, M Rosenfeld, H A Tiddens, C E Wainwright, for the ACFBAL Study Investigators

605
Journal of the British Thoracic Society

Pirfenidone for IPF: pro/con debate; the con viewpoint

G Raghu, D R Thickett

Impact Factor: 6.84

Editors

A Bush (UK) I Pavord (UK)

Deputy Editors

608

P Cullinan (UK) C Lloyd (UK)

Associate Editors
R Beasley (New Zealand) R Buhl (Germany) JC Celedn (USA) A Custovic (UK) P Gibson (Australia) J Grigg (UK) D Halpin (UK) A Jones (UK) E Lim (UK) N Maskell (UK) S Nathan (USA) JL Pepin (France) T Sethi (UK) M Steiner (UK) D Thickett (UK) A Torres (Spain) Z Udwadia (India) H Zar (South Africa)

Pulmonary exacerbations as indicators of progression of lung disease in young children with CF

D B Sanders, C H Goss

652

Intravenous antibiotics reduce the presence of Aspergillus in adult cystic brosis sputum
C G Baxter, R Rautemaa, A M Jones, A K Webb, M Bull, E Mahenthiralingam, D W Denning

610

Keeping a chest of the literature

J K Quint, A Bush, I Pavord

Epidemiology
658
OPEN ACCESS

Asthma
611 Detection of exacerbations in asthma based on electronic diary data: results from the 1-year prospective BIOAIR study
M Kupczyk, S Haque, P J Sterk, E Niz ankowska-Mogilnicka, A Papi, E H Bel, P Chanez, B Dahln, M Gaga, M Gjomarkaj, P H Howarth, S L Johnston, G F Joos, F Kanniess, E Tzortzaki, A James, R J M Middelveld, S-E Dahln, on behalf of the BIOAIR investigators

Effectiveness of inuenza vaccination in working-age adults with diabetes: a population-based cohort study
D Lau, D T Eurich, S R Majumdar, A Katz, J A Johnson

Statistical Editors

J Gibson (UK) T McKeever (UK)

Statistician

L Szatkowski (UK)
Journal club Editor

Pleural disease
664 Ambulatory treatment in the management of pneumothorax: a systematic review of the literature
F J H Brims, N A Maskell

J Quint (UK)
President, British Thoracic Society

A Woodcock
Editorial Ofce

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Asthma and the environment

619 Short-term impact of the smokefree legislation in England on emergency hospital admissions for asthma among adults: a population-based study
M Sims, R Maxwell, A Gilmore
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ISSN: 0040-6376 (print) ISSN: 1468-3296 (online)

Disclaimer: Thorax is owned and published by the British Thoracic Society and BMJ Publishing Group Ltd, a wholly owned subsidiary of the British Medical Association. The owners grant editorial freedom to the Editor of Thorax. Thorax follows guidelines on editorial independence produced by the World Association of Medical Editors and the code on good publication practice of the Committee on Publication Ethics. Thorax is intended for medical professionals and is provided without warranty, express or implied. Statements in the Journal are there sponsibility of their authors and advertisers and not authors institutions, the BMJ Publishing Group Ltd, the British Thoracic Society or theBMAunless otherwise specied or determined by law. Acceptance of advertising does not imply endorsement. To the fullest extent permitted by law, the BMJ Publishing Group Ltd shall not be liable for any loss, injury or damage resulting from the use of Thorax or any information in it whether based on contract, tort or otherwise. Readers are advised to verify any information they choose to rely on. Copyright: 2013 BMJ Publishing Group Ltd and the British Thoracic Society. All rights reserved; no part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise without the prior permission of Thorax. Thorax is published by BMJ Publishing Group Ltd, typeset by Techset and printed in the UK on acid-free paper. Thorax (ISSN No: 00406376) is published monthly by BMJ Publishing Group and distributed in the USA by Air Business Ltd. Periodicals postage paid at Jamaica NY 11431. POSTMASTER: send address changes to Thorax, Air Business Ltd, c/o Worldnet Shipping Inc., 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA.

Chronic obstructive pulmonary disease

625 Skeletal muscle molecular responses to resistance training and dietary supplementation in COPD
D Constantin, M K Menon, L Houchen-Wolloff, M D Morgan, S J Singh, P Greenhaff, M C Steiner

Cover caption: Axial high resolution CT reconstruction of contrast enhanced images (see Sharp et al., page 697).

634

Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: a cross-sectional study
R Powell, D Davidson, J Divers, A Manichaikul, J J Carr, R Detrano, E A Hoffman, R Jiang, R A Kronmal, K Liu, N M Punjabi, E Shahar, K E Watson, J I Rotter, K D Taylor, S S Rich, R Graham Barr
OPEN ACCESS

This article has been chosen by the Editor to be of special interest or importance and is freely available online. This article has been made freely available online under the BMJ Journals Open Access scheme. See http://thorax.bmj.com/site/about/guidelines.xhtml#open

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics www.publicationethics.org.uk

Contents Review
670
OPEN ACCESS

Volume 68 Issue 7 | THORAX July 2013

691
OPEN ACCESS

Blood brinogen as a biomarker of chronic obstructive pulmonary disease

A Duvoix, J Dickens, I Haq, D Mannino, B Miller, R Tal-Singer, D A Lomas

Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense?
V M McDonald, I Higgins, L G Wood, P G Gibson

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Research update
695 Research priorities in bronchiectasis
A De Soyza, J S Brown, M R Loebinger, on behalf of the Bronchiectasis Research & Academic Network

Research letter
677 3D contrast-enhanced lung perfusion MRI is an effective screening tool for chronic thromboembolic pulmonary hypertension: results from the ASPIRE Registry
S Rajaram, A J Swift, A Telfer, J Hurdman, H Marshall, E Lorenz, D Capener, C Davies, C Hill, C Elliot, R Condliffe, J M Wild, D G Kiely

Pulmonary puzzles
697 A hormonal effusion?
C Sharp, M Meller, A Moody, G Hands

Journal club summaries

700 Journal club summary page
B Prudon

PostScript
679 Correspondence

Miscellanea
618

Chest clinic Audit, research and guideline update

682 British Thoracic Society Paediatric Pneumonia Audit: a review of 3 years of data
S-Jane M Bowen, A H Thomson

Journal club: Outcomes after thoracoscopic versus open lobectomy

U Sartipy

686

Basic science for the chest physician

684 Obesity and susceptibility to severe outcomes following respiratory viral infection
M H Almond, M R Edwards, W S Barclay, S L Johnston

Journal club: Can continuous positive airway pressure reduce the incidence of cardiovascular disease in non-sleepy patients with obstructive sleep apnoea?
A Jeyabalan

698

Journal club: Triple therapy for idiopathic pulmonary brosis

M G Jones

Opinion
687 The COPD control panel: towards personalised medicine in COPD
A Agusti, W MacNee