VALIDATION OF SERUM BASED BIOMARKERS FOR PREECLAMPSIA

DISSERTATION SUBMITTED IN FULFILLMENT OF THE REGULATIONS FOR THE AWARD OF M.D. OBSTETRICS AND GYNAECOLOGY

Under the Guidance of DR. KANCHANAMALAI. K PROFESSOR

DIVISION OF OBSTETRICS AND GYNAECOLOGY PSG INSTITUTE OF MEDICAL SCIENCES & RESEARCH THE TAMILNADU DR. M.G.R. MEDICAL UNIVERSITY GUINDY, CHENNAI, TAMILNADU, INDIA APRIL 2012

PREDICTIVE VALUE OF SERUM PAPP-A IN FIRST TRIMESTER IN IDENTIFICATION OF WOMEN AT RISK OF PIH, IUGR, DOWNS SYNDROME, MATERNAL COMPLICATIONS

DISSERTATION SUBMITTED IN FULFILLMENT OF THE REGULATIONS FOR THE AWARD OF M.D. OBSTETRICS AND GYNAECOLOGY

DR. REENA ABRAHAM MD DIVISION OF OBSTETRICS AND GYNAECOLOGY PSG INSTITUTE OF MEDICAL SCIENCES & RESEARCH THE TAMILNADU DR. M.G.R. MEDICAL UNIVERSITY GUINDY, CHENNAI, TAMILNADU, INDIA APRIL-2012

DECLARATION

I hereby declare that this dissertation entitled "PREDICTIVE

VALUE OF SERUM PAPP-A IN FIRST TRIMESTER IN IDENTIFICATION OF WOMEN AT RISK OF PIH, IUGR, DOWNS SYNDROME, MATERNAL COMPLICATIONS was prepared by me under the direct guidance and

supervision of P!"#. DR. REENA ABRAHAM MD PSG Hospitals, Coimbatore !he dissertation is submitted to the "r # G $ #edical University in partial fulfillment of the University regulations for the award of #" degree in %bstetrics and Gynaecology !his dissertation has not been submitted for the award of any "egree or "iploma

CERTIFICATE

!his is to certify that D!. AMUTHA RANI.G has prepared this dissertation entitled "PREDICTIVE VALUE OF SERUM PAPP-A IN FIRST
TRIMESTER IN IDENTIFICATION OF WOMEN AT RISK OF PIH, IUGR, DOWNS SYNDROME, MATERNAL COMPLICATIONS under my overall

supervision and guidance in the Institute of PSG Institute of #edical Science and $esearch, Coimbatore in partial fulfillment of the regulations of !amil &adu D!. M.G.R. M$%&'() U*&+$!,&-. for the award of M.D. D$/!$$ &* O0,-$-!&', (*% G.*($'")"/..

ACKNOWLEDGEMENT I wish to e'press my sincere than(s and gratitude to my Professor

P!"#. DR. REENA ABRAHAM MD

"epartment of %bstetrics )

Gynaecology, PSG Institute of #edical Sciences ) $esearch for her guidance and encouragement all along in completing my study She showed me different ways of approach to study the problem and the need to be persistent to accomplish my goal I am e'tremely than(ful to P!"#. D!. S$$-1( P(*&'2$! MD DGO., DNB., H % ", "epartment of %bstetrics ) Gynaecology, P!"#. DR. T.V.CHITRA MD DGO.,
DNB., "epartment of %bstetrics ) Gynaecology, PSG Institute of #edical

Science ) $esearch for their cooperation e'tended for this study I wish to record my gratefulness and feeling of indebtedness to them for the support given to me during the period of this study I am so grateful to the P!&*'&3() D!. S. R(4()&*/(4 and M$%&'() D&!$'-"! D!. V&4()254(! G"+&*%(*, PSG Hospitals for permitting me to carry out this study I am so grateful to P!"#. M!.A*(*%, Head of the "epartment of *iochemistry and Prof M!,.U,1(, "epartment of *iochemistry in guiding helping me in the study I than( M!. K(!-1&2 in helping me in typing and editing in this study and also than( all the patients for the (ind cooperation +nd most of all I e'press gratitude to my family and my friends who helped me all the way through DR. AMUTHA RANI.G

CONTENTS

TITLES I&!$%"UC!I%& $-.I-/ %0 1I!-$+!U$+I#S %0 !H- S!U"3 #+!-$I+1S +&" #-!H%"S $-SU1!S ) +&+13SIS "ISCUSSI%& C%&C1USI%& $-0-$-&C-S +**$-.I+!I%&S #+S!-$ CH+$!

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