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  • Early Embryos Fuel Hopes For Shortcut To Stem

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    Researchers have grown human embryonic stem cells from an embryo that was younger than any used before. Previously, stem cells have been grown only from blastocyststage embryos. The new technique is quicker and simpler than previous methods and could boost the success rate for making embryonic stemcell lines, which are in short supply.

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    Early Embryos Fuel Hopes for Shortcut to Stem

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    Researchers have grown human embryonic stem cells from an embryo that was younger than any used before. Previously, stem cells have been grown only from blastocyststage embryos. The new technique is quicker and simpler than previous methods and could boost the success rate for making embryonic stemcell lines, which are in short supply.

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    9 visualizzazioni1 pagina

    Early Embryos Fuel Hopes For Shortcut To Stem

    Caricato da

    poural
    Researchers have grown human embryonic stem cells from an embryo that was younger than any used before. Previously, stem cells have been grown only from blastocyststage embryos. The new technique is quicker and simpler than previous methods and could boost the success rate for making embryonic stemcell lines, which are in short supply.

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    Earlyembryosfuelhopesforshortcuttostemcellcreation

    (Nature,vol.432,November2004,HelenPearson,NewYork) Inanadvancethatcouldboosttheproductionofstemcellsformedicalresearch, fertilityresearchershavegrownhumanembryonicstem cellsfromanembryothatwas youngerthananyusedbefore. YuryVerlinksyandhiscolleaguesattheReproductiveGeneticsInstitutein Chicago,IL,grewcellsfromfourdayoldhumanembryoscalledmorulae(see ReproductiveBioMedicineOnline www.rbmonline.com/Article/1558).Previously,stem cellshavebeengrownonlyfromblastocyststageembryos,whichareadayortwoolder andhavemorespecializedtissues. Researchersinthefieldsaythenewtechniqueisquickerandsimplerthan previousmethodsandcouldboostthesuccessrateformakingembryonicstemcelllines, whichareinshortsupply.Ittakesahugestepoutofthewholeprocess,saysPeter Braude,whostudieshumanembryonicstemcellsatGuys,KingsandSt.Thomas SchoolofMedicineinLondon. Verlinksyandhisteamattemptedtogrowstemcellsfrom46humanmorulaeleft overfrom invitrofertilization(IVF)treatment.Theysucceededinmakingeightstemcell linesasuccessrateroughlyequivalenttothatachievedusingblastocysts. Initspaper,theteampresentspreliminaryevidencethatthesestemcellsareable togenerateasimilarrepertoireofcelltypestothosegrownfromblastocysts.Theyhave alreadyusedbothtechniquestocreatealibraryofstemcelllinesfordiseaseresearch, includingmanycarryinggeneticabnormalities(seeNature429,6912004). Thenewmethodisadvantageousbecauseitavoidsthedelicatetaskofculturing embryosuntiltheygrowintoblastocysts,aperiodwhenperhapshalfofthemstop growingordie.Italsocutsoutalaboriousstepfromtheconventionaltechnique,inwhich theoutershelloftheblastocystisdestroyedtogainaccesstotheprecious2030stem cellsinside.Inthenewmethod,theentiremorulaofaround6070cellsisgrownin culture. Theadvanceisunlikelytoaffectthecontentiousglobaldebateovertheethicsof embryonicstemcellresearch,scientistssay.Opponentsofsuchresearchpointtothefact thatstemcelllinescanonlybecreatedbydestroyingahumanembryo. ButBraudenotesthatresearcherswillnowwanttotestthemoreradicalconcept ofgrowingstemcellsfromasinglecellpluckedfromamorulastageembryowithout damagingtherestofit.ThatwouldalsoraisetheprospectthatcoupleshavingIVF treatmentcouldasktohaveoneoftheirembryoscellsremovedbeforeitisimplantedin thewomb.Thecellcouldbegrownintoastemcelllineandstoredincasethechild shouldneeditfordiseasetherapyinthefuture. Becausethistechniquewouldavoiddestroyingtheentireembryo,stemcell researcherssaythatitcouldalsoservetoquellsomeoftheethicalargumentsagainstthe useofhumanembryosforresearch. Researchersmightalsousethenewmethodtogrowstemcellsfrommorulastage embryosthathavestalledintheirdevelopmentandareincapableofgrowingintobabies, suggestsstemcellresearcherJoseCibelliofMichiganStateUniversityinEastLansing. Youcouldremoveabigobstaclefromtheethicalstandpoint,hesays.

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