CONFIDENTIAL

AS/APR 2011/CHM561

UNIVERSITI TEKNOLOGI MARA FINAL EXAMINATION

COURSE COURSE CODE EXAMINATION TIME

QUALITY IN ANALYTICAL MEASUREMENT CHM561 APRIL 2011 3 HOURS

INSTRUCTIONS TO CANDIDATES 1. 2. 3. 4. This question paper consists of two (2) parts : PART A (5 Questions) PART B (5 Questions)

Answer ALL questions from PART A and four (4) questions from PART B in the Answer Booklet. Start each answer on a new page. Do not bring any material into the examination room unless permission is given by the invigilator. Please check to make sure that this examination pack consists of: i) the Question Paper ii) an Answer Booklet-provided by the Faculty

DO NOT TURN THIS PAGE UNTIL YOU ARE TOLD TO DO SO This examination paper consists of 4 printed pages
Hak Cipta Universiti Teknologi MARA CONFIDENTIAL

CONFIDENTIAL

AS/APR 2011/CHM561

PART A

OUESTION 1 Compare and contrast diagnostic sampling and preventive sampling in terms of sampling time and frequency. (4 marks)

QUESTION 2 A proper "chain-of-custody" procedures play a crucial role in forensic cases. Why? (4 marks)

QUESTION 3 Chemical standards and standard reference materials are important in chemical analysis to obtain the quality results. Differentiate between chemical standard and standard reference material. (4 marks)

QUESTION 4 Briefly, explain four common sources of uncertainty. (4 marks)

QUESTION 5 Differentiate between a Quality Manual and a Quality Management System? (4 marks)

Hak Cipta Universiti Teknologi MARA

CONFIDENTIAL

CONFIDENTIAL

AS/APR 2011/CHM561

PARTB

QUESTION 1 Samples of surface water were collected using a water sampler and transferred into 2 liter glass bottles. Triplicate samples were taken for each sampling point. After sample pretreatment, the samples were stored in the dark at temperature between 0 to -4 C prior to solid phase extraction. The extract obtained was concentrated to 1 mL and the amount of pesticides was determined by injecting 1 uL of the aliquot into a gas chromatography with mass spectrometry detector. a) List 3 common sample pretreatment for a water sample. (3 marks) b) Name one type of water sampler and state one important features of the sampler. (3 marks) c) Differentiate between the term 'sample' and 'aliquot'. (4 marks) QUESTION 2 In the development of a new extraction method using solid phase microextraction, three important parameters considered are temperature, extraction time and desorption time. Compare and contrast the steps involved in optimizing the method using experimental design (DoE) approach and one factor at a time approach. (10 marks) QUESTION 3 Method validation is carried out to ensure that the performance characteristics of a method and to demonstrate that the method is scientifically sound under the conditions in which it is to be applied. List five important performance characteristics and explain why it is important? (10 marks) QUESTION 4 a) Compare and contrast stratified and judgemental sampling emphasizing on the relative advantages and disadvantages of the sampling plan. (4 marks) Discuss how to asses the ruggedness and robustness of your analytical instrument. (6 marks)
CONFIDENTIAL

b)

Hak Cipta Universiti Teknologi MARA

CONFIDENTIAL

AS/APR 2011/CHM561

QUESTION 5 You are employed in an analytical laboratory which involves in developing tests for pesticide residue in food. You are asked to set up a Quality System as the company decided to be assessed and certified by an independent accreditation body. a) What is Quality System? (2 marks) b) Discuss about the ISO 9000 certification and GLP compliance. Choose the most suitable standard for your Quality System. (8 marks)

END OF QUESTION PAPER

Hak Cipta Universiti Teknologi MARA

CONFIDENTIAL