UNIVERSITY OF MYSORE

SYLLABUS FOR M. Sc. DEGREE COURSE (CHOICE BASED CREDIT SEMESTER SCHEME)

ORGANIC CHEMISTRY

2010-2011

M. Sc Course in Organic Chemistry Syllabus Title of the paper Credits L T P Duration of Marks in examination the examination & & & / / & & & & & & )(*'( )(*'( )(*'( ,(*#( ,(*#( )(*'( )(*'( )(*'( )(*'( )(*'( )(*'( 1((

OC#.# OC#.' OC#.& OC#., OC#.0 OC#./# OC#./' OC#./& OC#./, OC#.1# OC#.1'

Stereochemistry $ %eaction mechanism Spectroscopy+ " , & ' ( Principles of "norganic & ' ' ( Chemistry -nalytical."norganic Chemistry ' ( ( , Practical Organic.Physical Chemistry ' ( ( , Practical S $% c r! "a"!r# (a&' %( ) Substitution and addition ' ' ( ( reactions Carbohydrates $ Peptides ' ' ( ( Chromatography ' ' ( ( -lkaloids and steroids ' ' ( ( Cr ## ) rd!r (a&' &!) 2asic concepts in organic ' ' ( ( chemistry Chemistry for biologists ' ' ( ( T %a* cr!d+%# '( Title of the paper Credits L T P

onor!s " Semester Hard c r! "a"!r# & ' ' (

Duration of Marks in examination the examination & & & / / & & & & )(*'( )(*'( )(*'( ,(*#( ,(*#( )(*'( )(*'( )(*'( )(*'(

OC'.# OC'.' OC'.& OC'., OC'.0 OC'./# OC'./' OC'./& OC'./,

onor!s "" Semester Hard c r! "a"!r# Spectroscopy & ' ' ( %eagents and Synthesis , & ' ( Principles of Physical Chemistry & ' ' ( Organic chemistry Practical3 ' ( ( , 4ualitati5e analysis Organic Chemistry Practical3 ' ( ( , "solation of natural products Soft core papers 6-ny t7o8 Principles of -nalytical chemistry ' ' ( ( Lipids and 9itamins ' ' ( ( eterocyclic chemistry ' ' ( ( Medicinal chemistry+" ' ' ( (

Cr ## ) rd!r (a&' &!) OC'.1# Chemistry of natural products ' ' ( ( OC'.1' Material chemistry ' ' ( ( T %a* cr!d+%# '( Masters " Semester 6"""8 Hard c r! "a"!r# OC&.# OC&.' OC&.& OC&., OC&.0 OC&./# OC&./' OC&.1# OC&;1' Molecular rearrangements and :reen chemistry 2onding; Photochemistry $ Pericyclic reactions Organometallics and organononmetallics Multistep synthesis 4uantitati5e analysis & , & ' & ' ' ' ' ( ( (

& &

)(*'( )(*'( 1((

& & & / / & & & &

)(*'( )(*'( )(*'( ,(*#( ,(*#( )(*'( )(*'( )(*'( )(*'( /((

' ( ( , ' ( ( , Soft core papers 6any one8 2iophysical chemistry ' ' ( ( 2ioinorganic chemistry ' ' ( ( Cr ## ) rd!r 6any one8 Chemistry of biomolecules ' ' ( ( %ole of chemistry in animal health ' ' ( ( and gro7th. T %a* cr!d+%# #) Title of the paper Credits L T P

Duration of Marks in examination the examination & & & & & & & )(*'( )(*'( )(*'( #(( )(*'( )(*'( )(*'( )(*'( /((

OC,.# OC,.' OC,.& OC,.,

2iomolecules Medicinal Chemistry+"" Dyes $ "nsecticides Dissertation

OC,.0# Life style chemicals OC,.0' Medicinal Chemistry+""" Total credits

Masters "" Semester Hard c r! "a"!r# , & ' ( & ' ' ( & ' ' ( , ( ( ) Soft core papers 6any one8 ' ' ( ( ' ' (

Cr ## ) rd!r (a&' &!) OC,./# Chemistry of soil and fertili<ers ' ' ( ( OC,./' -pplication of synthetic products ' ' ( ( T %a* cr!d+%# #)

GENERAL RE,UIREMENTS #. -ll hard core papers are compulsory. '. -ny t7o soft core sub=ects of ' credits per course may be selected in onors degree and one soft core paper in Masters degree. &. The students 7ho ha5e studied or opted as hard core.soft core sub=ects in any other or in the respecti5e departments; are not eligible for opting these sub=ects. ,. Minimum of #( students are eligible to study open electi5es in the department. 0. Open electi5e sub=ects are only for students of departments other than chemistry and organic chemistry. /. -dmission rules and regulations are laid do7n as per the >ni5ersity of Mysore. 1. DISSERTATION- Preparation of dissertation on the topic assigned. This include literature collection; identification of ob=ecti5es; methodology follo7ed; analytical instruments used; data collected; analysis of data; data synthesis and conclusions. The material collected has to be submitted in a bound 5olume from one month before the commencement of practical examination. - certificate has to be enclosed stating that the material collected and presented in the Dissertation has not been submitted for the a7ard of any Dissertation.Degree in this >ni5ersity or in any other >ni5ersity signed by the candidate and the guide.
Chairman 2OS in Organic chemistry

onor!s " Semester OC1.1 Hard c r!- Or.a&+c C/!0+#%r' 1S%!r! c/!0+#%r' a&d r!ac%+ & 0!c/a&+#0 U&+% I S%!r! +# 0!r+#0- Pro=ection formulae ?fly; 7edge; @ischer; Ae7man and sa7 horseB. O"%+ca* +# 0!r+#03 Conditions for optical isomerism; optical isomerism due to chiral centers and molecular dissymmetry; allenes and biphenyls; criteria for optical purity. enantiomorphs; diastereoisomers; racemic mixtures and their resolution; configurational notations of simple molecules; DL and %S configurational notations. G! 0!%r+ca* +# 0!r+#03 "somorphism due to CCC; CCA and ACA bonds; D;E con5entions; determination of configuration by physical and chemical methods. C &$ r0a%+ &a* a&a*'#+#3 Dlementary account of conformational eFuilibria of ethane; butane and cyclohexane; Conformation of cyclic compounds such as cyclopentane; cyclohexane; cyclohexanone deri5ati5es and decalins. Conformational analysis of #;'+G #;&+G #;,+ disubstituted cyclohexane deri5ati5es; D+glucose. Dffect of conformation on the course of rate of reactions. S%!r! #!*!c%+2+%'3 Stereoselecti5e reactions; diastereoselecti5e reactions; stereospecific reactions; regioselecti5e $ regiospecific reactions. 314 HOURS5 U&+% II S%r6c%6r! a&d r!ac%+2+%' $ r.a&+c c 0" 6&d#3 -cids and 2ases; functional group effects on acidity and basicity; hydrogen bonding; resonance; inducti5e and hypercon=ugation effects. Meaning and importance of reaction mechanism; Classification of reactions D!%!r0+&a%+ & $ r!ac%+ & 0!c/a&+#0 )' 7+&!%+c a&d & &-7+&!%+c 0!%/ d# 3 Kinetic methods3 Mechanistic implications from rate la7s; the transition state theory; ambiguities in interpreting kinetic data; sol5ent effect; ionic effect; isotopic effect; sol5ent isotopic effect; substituent effect; steric effect; linear free energy relationshipsH ammett eFuation and Taft treatment. N &-7+&!%+c 0!%/ d#3 Dnergy profile diagram; identification of products; testing possible intermediates; trapping of intermediates; cross o5er experiments; isotopic labeling; stereochemical studies; limitations of reactions. 314 HOURSB R!$!r!&c!# #. '. &. ,. 0. /. 1. ). ". L. @inar; Organic Chemistry; DL2S Longmann; 9ol. " $ ""; #I),. D. L. Dlliel and S. . Jilen; Stereochemistry of Organic Compounds; Kohn Jiley and Sons; Ae7 Lork. #II,. "ntroduction to stereochemistry H M. Mislo7. %. M. 2ansal; Organic %eaction Mechanism; Jiley Dastern Limited; Ae7 Delhi; #II&. K. March; -d5anced Organic Chemistry; Jiley "nterscience; #II,. D. S. :ould; Mechanism and Structure in Organic Chemistry; alt; %inhart $ Jinston; Ae7 Lork; I/,. - :uide book to mechanism in Organic Chemistry H Petersykes Stereochemistry and mechanism through sol5ed problems H P. S. Malsi.

I. #(. ##.

@. -. Carey and Sundberg; -d5anced Organic Chemistry H Part - $ 2; &rd edition; Plenum Press; Ae7 Lork; #II(. D. Aasipuri; Stereochemistry of Organic Compounds; 'nd edition; Jiley Dastern Limited; Ae7 Delhi; #II#. S. M. :hosh; -d5anced :eneral Organic Chemistry; 2ook and -lleied 6P8 Ltd; #II). OC1.2 Hard C r!- S"!c%r #c "' U&+% I

UV-V+#+)*! #"!c%r #c "'3 Modes of electronic excitations; simple chromophoric groupsHsystems of extended con=ugation; aromatic systems. Types of auxochromesHfunctions of auxochromes; absorption and intensity shift. Types of transition probability; types of absorption bonds; sol5ent effects and choice of sol5ent. Dffect of polarity on 5arious type of bonds; Jood7ards empherical rules for predicting the 7a5elength of maximum absorption3 + Olefins; con=ugated dienes; cyclic trienes and polyenes; ;+unsaturated aldehydes and ketones; ben<ene and substituted ben<ene rings. IR #"!c%r #c "'- Principles; ook!s la7; characteristic group freFuencies and skeletal freFuencies. @inger print region. "dentification of functional groups3 -lkenes; alkynes; aromatics; carbonyl compounds 6aldehydes and ketones; esters and lactones8; halogen compounds; sulphur and phosphorous compounds; amides; lactams; amino acids; and imines. @actors affecting group freFuencies and band shapes; con=ugation; resonance and inductance; hydrogen bonding and ring strain; tautomerism; cis+trans isomerism. -pplications of "% spectra to co+ordinatation compounds; organotransition metal complexes 6A;A+dimethyl acetamides; urea; DMSO; AO &+; SO,++; AO'+8 ?14 Hr#5 U&+% II N6c*!ar 0a.&!%+c r!# &a&c! #"!c%r #c "'3 :eneral introduction and definition; magnetic properties of nuclei 6magnetic moment; g factor8 and theory of nuclear resonance. Larmor precession freFuency; resonance condition and relaxation processes. C/!0+ca* #/+$%3 Standards employed in AM%; factors affecting chemical shift; electro negati5ity; shielding and deshielding mechanism; 9ander 7aals deshielding; +bonding; diamagnetic and paramagnetic anisotropics. Spin+spin coupling; chemical shift 5alues and correlation for protons bonded to carbon and other nuclei. "nstrumentation and sample handling. ESR S"!c%r #c "'3 2asic principles H "ntensity; 7idth; position and multiple structure. :eneral rules for the interpretation of the spectra. Eero field splitting and Mramer!s degeneracy . @actors affecting the magnitude of Ng! 5alue. Double resonance+DADO% and DLDO%. -pplications H study of free radicals; structure determinations; biological study; coordination compound and analytical applications. 314 /r#B U&+% III Ma## #"!c%r 0!%r'3 Principles; instrumentation; different methods of ioni<ation; D"; C"; @D and @-2; ion separators3 single focusing separator 7ith magnetic diffraction; focusing analy<er; time+ ofHflight separator and Fuadruple analy<er. Mass spectra3 molecular ion; base peak; meta+stable peak; nitrogen rule and McLafforty rearrangement. Mass spectral fragmentation of organic

compounds and common functional groups3 normal and branched alkanes; alkenes; cycloalkanes; ben<ene and its deri5ati5es; alcohols; phenols; aldehydes and ketones; carboxylic acids; and their deri5ati5es; amines; nitro compounds. Determination of molecular formula by accurate molecular 7eight and isotopic abundance methods. LC+MS; LC+MS.MS; :C+MS3 Principles and applications. ?#/ O>%S5 R!$!r!&c!# #. Spectroscopy by 2. P. Straughan and S. Jalker; Kohn Jiley $ Sons "nc.; Ae7 Lork; 9ol. '; #I1/. '. Organic spectroscopy by Jilliam Memp; DL2S Society; MacMillan; #I)1. &. -pplication of absorption spectroscopy of organic compounds by Kohn %. Dyer; Prentic+ all of "ndia Pri5ate Ltd.; Ae7 Delhi; #I1,. ,. Organic spectroscopy by 9. %. Dhani; Tata Mc:ro7+ all publishing company Ltd.; Ae7 Delhi; #II0. 0. Spectrometric identification of organic compounds; ,th edition; %obert M. Sil5erstein; :. Clayton 2assler and Terence C. Morrill; Kohn Jiley $ Sons "nc.; Ae7 Lork; 9ol. #; #I)#. /. "nterpretation of carbon+#& AM% spectra; @. J. Jehrli and T. Jirthlin; eyden; London; #I1/. OC1.8 Hard c r!- 9r+&c+"*!# $ I& r.a&+c C/!0+#%r'-I U&+%-I I &+c B &d- Properties of ionic substances; structures of crystal lattices 6AaCl; CsCl; and EnS8. Lattice energy; 2orn+ aber cycle; uses of 2orn+ aber type calculations; 2orn+Lande eFuation. "onic radii; factors affecting the radii of ions; radius ratio effects; co5alent character in ionic bonds; hydration energy and solubility of ionic compounds. C 2a*!&% B &d- M.O. treatment for homonuclear and heteronuclear diatomic molecules. M.O. treatment in5ol5ing delocali<ed +bonding 6CO&'+; AO&+; AO'+; CO' and A&+8. Jeak interactions in co5alent substances. 9SDP% model for explaining structure of molecules including fluxional molecules; short comings of the 9SDP% model. 314 HOURS5 >A"T H"" C rd+&a%+ & C/!0+#%r'- :eometries of metal complexes of higher coordination numbers 6'+ #'8. Step7ise and o5erall stability constants of coordination compounds; factors influencing the stability of metal complexes 7ith reference to the nature of metal ion and ligand; the "r5ing+ Jilliam series; chelate effect. Theoretical aspects of the determination of stability constants of the coordination compounds by spectrophotometric; p metric; and polarographic methods. Cr'#%a* F+!*d T/! r'- Salient features of C@T; d+orbital splitting in octahedral; tetrahedral; sFuare planar and tetragonal complexes; measurement of #(DF. Spectrochemical series; short comings of C@T; e5idences of M+L co5alency. 314 HOURS5

R!$!r!&c!##. "norganic Chemistry 6,th edition83 K.D. uheey; D.-. Meiter and %.L. Meiter 6#II&8G arper Collins. '. "ntroduction to modern inorganic chemistry 6,th edition83 M.M. Mackay and %.-. Mackay 6#I)I83 2lackie. &. -d5anced "norganic Chemistry 60th edition83 @.-. Cotton and :. Jilkinson 6#II(83 Jiley. ,. Concise "norganic Chemistry 60th edition83 K.D. Lee 6'(((8G 2lack7ell Science. 0. Concepts and Models of "norganic Chemistry 6&rd edition83 2.D. Douglas; D. . Mc Daniel and -lexander. 6'((#83 Jiley. /. "norganic Chemistry 6&rd edition83 Shri5er; -tkins and Langford 6#III8G Oxford >ni5. Press. OC1.: Hard c r!- A&a*'%+ca*;I& r.a&+c c/!0+#%r' "rac%+ca*#
P-%TH"3 -A-LLT"C-L

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#. Determination of carbonate and bicarbonate in a mixture by p +metric titration and comparison 7ith 5isual acid+base titration. '. Determination of total acidity of 5inegar and 7ines by acid+base titration. &. Determination of total hardness of 7ater by complexation titration using DDT-. ,. Determination of percentage of chloride in a sample by precipitation titration+Mohrs; 9olhard and @a=ans methods. 0. Potentiometric determination of the eFui5alent 7eight and Ma for a pure unkno7n 7eak acid. /. Determination of chloride content of an industrial effluent by conductometric titration 7ith sil5er nitrate. 1. -nalysis of 7aste 7ater for DO and 2OD by titrimetry. acid as chromogenic agent. I. Spectrophotometric determination of creatinine in urine. a. reducing sugars by titrimetry and spectrophotometry b. urea and uric acid by titrimetry and spectrophotometry. c. "norganic phosphorus by spectrophotometry. d. Sulphate by precipitation titration after ion+exchange separation. ##. -nalysis of blood for a. cholesterol by spectrophotometry b. urea and uric acid by spectrophotometry c. bicarbonate by acid+base titration. #(. -nalysis of urine for ). Determination of nitrate nitrogen in 7ater by spectrophotometry using phenol disulphonic

#'. Mercuricmetric determination of blood or urine chloride. #&. Determination of calcium in milk po7der by DDT- titration. #,. Determination of iron in pharmaceuticals by 5isual and potentiometric titration using cerium6"98 sulphate. #0. Spectrophotometric determination of iron in natural 7ater by thiocyante.orthophenanthroline method. #/. Determination of 5itamin - in 5anaspathi. #1. -ssay of aspirin.caffeine.phenacetin by u5+spectrometry. #). Determination of sulpha drugs by potentiometry using AaAO'. %eferences #. @undamental of -nalytical Chemistry; D.-. Skoog; D.M. Jest; oller and Crouch ) th edition; '((0; Saunders College Publishing; Ae7 Lork. '. -nalytical Chemistry; :.D. Christian; 0th ed.; '((# Kohn Jiley $ Sons; "nc; "ndia. &. 4uantitati5e -nalysis; %.-. Day and -.L. >nder7ood; / th edition;#II& prentice all; "nc. Ae7 Delhi. ,. 9ogel!s Textbook of 4uantitati5e Chemical -nalysis; K. Mendham; %.C. Denney; K.D. 2arnes and M.K.M. Thomas; /th edition; Third "ndian %eprint.'((& Pearson Dducation P5t. Ltd.; Ae7 Delhi. 0. -nalytical Chemistry Principles; Kohn . Mennedy; 'nd edition; Saunders College Publishing; California; #II(. /. Practical Clinical biochemistry methods and interpretations; %.Cha7la; K.P. 2others Medical Publishers 6P8 ltd.; #II0. 1. Laboratory manual in biochemistry; K. Kayaraman; Ae7 -ge "nternational Publishers; Ae7 Delhi; #I)#. ). Practical clinical 2iochemistry+ arold 9arley and -rnold. ein Mann; ,th edn. I. Dn5ironmental science3 Laboratory Manual; Maurice -. Strabbe; The C.9.Mosbey Co. Saint Loucs; #I1'. #(. Dxperiments in en5ironmental chemistry; P.D.9o7ler; and D.J.Counel; Pergamon press; Oxford #I)(. Part "" "norganic chemistry 1. A&a*'#+# $ Or!#1. ematite a. insoluble 6gra5imetrically8 b. iron titrimetrically using cerium6"98 solution ). Dolomite a. insoluble 6gra5imetrically8 b. calcium and magnesium using DDTI. Pyrolusite a. insoluble 6gra5imetrically8 b. Manganese dioxide titrimetrically using permanganate.
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2. Micro+5olumetric estimation of calcium using DDT-. 8. A&a*'#+# $ a** '#a8 Solder H lead and tin using DDTb8 Copper Hnickel alloy 6i8 Copper 5olumetrically using M"O& 6ii8 Aickel gra5imetrically using DM: :. ,6a&%+%a%+2! a&a*'#+# $ 0+<%6r!#a8 Chloride and iodide 6i8 iodide 5olumetrically using M"O& 6ii8 total halide gra5imetrically b8 Calcium and lead H using DDT=. S"!c%r "/ % 0!%r+c d!%!r0+&a%+ & $a8 iron using thiocyanate.#;#(+phenonthroline b8 chromium using diphenyl carba<ide c8 nickel using dimethylglyoxime d8 titanium using hydrogen peroxide 4. C+rc6*ar "a"!r c/r 0a% .ra"/' 1#!"ara%+ & $a8 iron and nickel b8 copper and nickel R!$!r!&c!# #. - Text 2ook of 4uantitati5e "norganic -nalysis H -.". 9ogel. """ edition '. 9ogel!s Text 2ook of 4uantitati5e Chemical -nalysis H K. 2asset; %.C. Denney; :. . Keffery and K. Mendhom. &. Spectrophotometric determination of elements H E. Marc<enko. ,. 9ogel!s 4ualitati5e "norganic -nalysis H S5elha. 0. Macro and Semimicro inorganic Fualitati5e analysis H -.". 9ogel. /. Semimicro 4ualitati5e -nalysis H @. K. Jelcher and %.2. alin. OC1.= Hard c r!- Or.a&+c;9/'#+ca* c/!0+#%r' "rac%+ca*
P-%T+"3 Organic chemistry

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Material Safety Data Sheet 6MSDS83-nalysis of MSDS for all chemicals; noting the ha<ards and biological effects in the laboratory note book before doing the experiment. Or.a&+c 9r!"ara%+ &#3 Preparations in5ol5ing oxidation; reduction; dehydration; nitration; dia<oti<ation; cycli<ation; condensation; addition reactions. %eport the yield and cost per Mg of the product synthesi<ed and the cost from the catalogue. #. '. &. Preparation of aniline from nitroben<ene 6%eduction8. Preparation of p+nitroacetanilide from acetanilide. Preparation of n+butyl bromide from n+butanol.

,. 0. /. 1. ). I. #(. ##. #'. #&. #,. #0.

Preparation of o+iodoben<oic acid from anthranilic acid 6Sandmeyer reaction8. Preparation of osa<one deri5ati5e. Preparation of penta+O+acetyl+D+glucose from glucose. Preparation of cis and trans cinnamic acid. Preparation of phenoxy acetic acid. Preparation of hippruic acid from glycine. Preparation of p+nitroben<oic acid from p+nitrotoluene 6Oxidation8. Preparation of 1+hydroxy+,+methyl coumarin. Preparation of m+nitroben<oic acid from methyl ben<oate. Preparation of aspirin. Preparation of Tetrahydrocarba<ole from cyclohexanone 6@ischer indole synthesis8. Preparation of 0+Chloro+'+hydroxyacetophenone from ,+chlorophenol 6@ries rearrangement8.

R!$!r!&c!#. '. &. ,.

Kinetics

- Text book of practical organic chemistry H -. ". 9ogel 9ol. ". Practical Organic Chemistry H Mann $ Saunders. Manual of Organic Chemistry H Dey and Seetharaman. -n introduction to practical organic chemistry H %obert; 9ingro5e etc. Hard C r!- 9/'#+ca* C/!0+#%r' 9rac%+ca*
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#. Study of kinetics of hydrolysis of an ester using Cl. 'SO, at t7o different temperatures; determination of rate constants and energy of acti5ation. '. Study of kinetics of reaction bet7een M'S'O) and M"; first order; determination of rate constants at t7o different temperatures and Da. &. Study of kinetics of reaction bet7een M 'S'O) and M"; second order; determination of rate constant and Da. ,. Study of kinetics of reaction bet7een C-T and indigocarmine spectrophotometrically and determination of rate constant. 0. Determination of energy of acti5ation for the bromide+bromate reaction. Conductometry /. Conductometric titration of a mixture of Cl and C &COO against AaO . 1. Determination of eFui5alent conductance at infinite dilution of a strong electrolyte and 5erification of Onsager eFuation. ). Determination of dissociation constant of a 7eak electrolyte by conducti5ity method. I. Conductometric titration of formic acid.oxalic acid against AaO and A ,O . #(. Potentiometric titration of M" 5s MMnO, solution. ##. Determination of dissociation constant of a 7eak acid by potentiometric method. #'. Potentiometric titration of -gAO& 5s MCl. #&. Determination of redox potential and estimation of @e'* ions by potentiometric method. #,. To obtain the absorption spectra of coloured complexes; 5erification of 2eer!s la7 and estimation of metal ions in solution using a spectrophotometer. #0. Spectrophotometric titration of @eSO, against MMnO,. #/. Determination of heat of solution of ben<oic acid.salicylic acid by 5ariable temperature method 6graphical method8. #1. Thermometric titration of an acid 7ith a base.

#). Determination of molecular 7eight of a compound using 2eckmann!s cryoscopic method using ben<ene or.and 7ater as sol5ent. #I. Determination of partial molar 5olume of 6a8 AaCl+ 'O and 6b8 C' 0O + 'O systems. '(. Determination of degree of association of ben<oic acid in ben<ene by distribution method. R!$!r!&c!# #. '. &. ,. 0. /. 1. ). I. Practical Physical Chemistry H -.K. @indlay. Dxperimental Physical Chemistry H@. Daniels et al. Selected Dxperiments in Physical Chemistry H Latham. Dxperiments in Physical Chemistry H Kames and Prichard. Dxperiments in Physical Chemistry H Shoemaker. -d5anced Physico+Chemical Dxperiments HK. %ose. Practical Physical Chemistry HS.%. Palit. Dxperiments in Physical Chemistry H Lada5; :eol Publishing ouse. Dxperiments in Physical Chemistry H Palmer. OC 1.41 S $% c r!- Or.a&+c r!ac%+ &# a&d 0!c/a&+#0 U&+% I S6)#%+%6%+ & r!ac%+ &# H Minetics; mechanism and stereochemical factor affecting the rate of S A#; SA'; S%Ai; SAi; SA#!; SA'!; SA#i; reactions; Aeighbouring group participation. E*!c%r "/+*+c #6)#%+%6%+ & r!ac%+ &# H Minetics; mechanism and stereochemical factor affecting the rate of SD# $ SD' Ar 0a%+c !*!c%r "/+*+c #6)#%+%6%+ & r!ac%+ &#3 Mechanism of nitration; halogenation; sulphonation; @riedel+Crafts alkylation and acylation; Mannich reaction; chloromethylation; 9ilsmeier aack reaction; Dia<onium coupling; :attermannHMoch reaction; Mercuration reaction. Ar 0a%+c &6c*! "/+*+c #6)#%+%6%+ & r!ac%+ &#3 SA#; SA' and ben<yne mechanism; 2ucherer reaction; 5on %ichter reaction. 314 HOURS5 U&+% II Add+%+ & r!ac%+ &#3 -ddition to C+C multiple bonds in5ol5ing electrophiles; nucleophiles and free radicals. Marko7nikoff!s rule and antiMarko7nikoff!s rule; ydroboration. T'"+ca* add+%+ &# % car) &'* c 0" 6&d#3 -ddition of hydride; 7ater; alcohol; thioalcohol; bisulphite; CA; :rignard reagents and amino compounds to carbonyl compounds. A*d * a&d r!*a%!d r!ac%+ &#3 Meto+enol tautomerism; mechanism and synthetic applications of aldol condensations; Claisen reaction; Schmidt reaction; Perkin reaction; Mnoe5enogel; ben<oin; Stobbe and Dar<en!s glysidic ester condensation; Canni<aro reaction; Tishchenko reaction; Michael addition; %obinson!s annulation reactions. M!c/a&+#0 of ester formation and their hydrolysis; formation and hydrolysis of amides; decarboxylation mechanisms. E*+0+&a%+ & r!ac%+ &#3 Mechanism and stereochemistry of eliminationsHD#; D'; D#cb mechanism; cis+elimination; ofmann and Sayt<eff eliminations; competition bet7een elimination and substitution; Chugae5 reaction. 314 HOURS5

%eferences #. '. &. ,. 0. /. 1. ). ". L. @inar; Organic Chemistry; DL2S Longmann; 9ol. " $ ""; #I), K. March; -d5anced Organic Chemistry; Jiley "nterscience; #II,. D. S. :ould; Mechanism and Structure in Organic Chemistry; alt; %inhart $ Jinston; Ae7 Lork; #I/,. @. -. Carey and Sundberg; -d5anced Organic Chemistry H Part - $ 2; &rd edition; Plenum Press; Ae7 Lork; #II(. Comprehensi5e Organic Synthesis H 2. M. Trost and ". @leming series; Pergamon Press; Ae7 Lork; #II#. - :uide book to mechanism in organic chemistry H Petersykes. S. M. :hosh; -d5anced :eneral Organic Chemistry; 2ook and -lleied 6P8 Ltd; #II) %. M. 2ansal; Organic %eaction Mechanism; Jiley Dastern Limited; Ae7 Delhi; #II& OC1. 42 S $% c r!- Car) /'dra%!# a&d "!"%+d!# U&+% I M & #acc/ar+d!#3 "ntroduction; general reactions; ring si<e determination of monosaccharides; configuration and conformations of monosacharides; anomeric effect; udson!s rules; epimeri<ation and mutarotation. Synthesis and biological importance of glycosides; amino sugars; anhydrosugars. D+##acc/ar+d!#3 Structure; synthesis and biological aspects of sucrose; maltose and lactose. "ndustrial applications of sucrose. 9 *'#acc/ar+d!#3 :eneral methods of structure elucidation. (14 HOURS) >nit "" A0+& ac+d#3 :eneral structure; essential amino acids physiological properties; isoelectric points; buffers Ophosphate and acetate buffers8 and t7o methods of synthesis 6:abriel phthalimide synthesis and Strecker synthesis8. 9!"%+d!#3 Peptide bond; structure determination3 -mino acid residue analysis; C and A+terminal determination; selecti5e clea5age of peptide bonds 6t7o chemical and biochemical methods8G Peptide synthesis3 + Protection of amino group 62oc; Cb<; @moc+8; carboxyl group as alkyl and aryl esters and acti5ation of carboxylic groups; solution and solid phase techniFues; use of DCC and Merrifield!s resin; %acemi<ation during peptide synthesis; synthesis of oxytocin; insulin; 5asopressin and gramicidin; brief account of MS ; -CT and O2T. (14 HOURS) R!$!r!&c!# #. ". L. @inar; Organic Chemistry; DL2S Longmann; 9ol. " $ ""; #I),. '. M. -lbert; L. Lehninger; D. L. Aelson; M. M. Cox; Principles of 2iochemistry; C2E publishers; #st edition; Ae7 Delhi; #II&. &. arper!s 2iochemistry; Dd. %. arper; ''nd edition; Prentice all Press; Ae7 Lork; #II(. ,. Dncyclopedia of Chemical technology H Mirck+Othmer series 0. arper!s re5ie7 of biochemistry H P. J. Martin; P. -. Mayer $ 9. J. %odf7ell; 0th edition; Maur<en -sian Ddition; California; #I)#. OC1. 48 S $% c r!- C/r 0a% .ra"/'

U&+% I F6&da0!&%a*# $ c/r 0a% .ra"/'3 :eneral description; definition; terms and parameters used in chromatography; classification of chromatographic methods; criteria for selection of stationary and mobile phase+nature of adsorbents; factors influencing the adsorbents; nature and types of mobile phases and stationary phases. C *60& c/r 0a% .ra"/'3 Theories H plate theory; rate theory; band broadening+eddy diffusion; longitudinal diffusion and resistance to mass transfer; column efficiency; 9an Deemter!s eFuation and its modern 5ersion; optimi<ation column performance; interrelationships+capacity factor; selecti5ity factor; column resolution; distribution constant and applications of con5entional column chromatography; ad5antages and limitations. T/+& *a'!r c/r 0a% .ra"/' (TLC)3 Definition; mechanism; efficiency of TL plates; methodology Hselection of stationary and mobile phases; preparation of micro and macro plates; de5elopment; spray reagents; identification and detection; reproducibility of %f 5alues; Fualitati5e and Fuantitati5e analysis. 9a"!r c/r 0a% .ra"/' (9C)- Definitions; theory and principle; techniFuesG one; t7o+ dimensional and circular PC; mechanism of separation; types of paper; methodology+preparation of sample; choice of sol5ents; location of spots and measurement of %f 5alue; factors affecting %f 5alues; ad5antages and applications 314 HOURS5 U&+% II H+./ "r!##6r! *+>6+d c/r 0a% .ra"/' (H9LC): -pparatus; pumps; column packing; characteristics of liFuid chromatographic detectors+>9; "%; refractometer and fluorescence detectors; ad5antages and applications. Ga# c/r 0a% .ra"/' (GC)3 Principle; instrumentations; columns; study of detectors Hthermal conducti5ity; flame ioni<ation; electron capture and mass spectrometry; factors affecting separation; retention 5olume; retention time; applications. I & !<c/a&.! c/r 0a% .ra"/' (IEC)- Definitions; principle; reFuirements for ion+exchange resin and its synthesis; types of ion+exchange resins; basic features of ion+exchange reactions; resin properties+ion+exchange capacity; resin selecti5ity and factors affecting the selecti5ity; applications of "DC in preparati5e; purification and reco5ery processes. S *2!&% !<%rac%+ &: definition; types; principle and efficiency of extraction; seFuence of extraction process; factors affecting extraction+p and oxidation state; masking and salting out agents; techniFues+batch and continuous extraction; applications. 314 HOURS5 R!$!r!&c! ) 7#3 #. -nalytical Chemistry; :.D. Christian; 0th ed.; Kohn Jiley $ Sons; "nc; "ndia; '((#. '. 9ogel!s Textbook of 4uantitati5e Chemical -nalysis; K. Mendham; %.C. Denney; K.D. 2arnes and M.K.M. Thomas; /th edition; Pearson Dducation P5t. Ltd.; Ae7 Delhi; '((,. &. -nalytical Chemistry Principles; Kohn . Mennedy; 'nd edition; Saunders College Publishing; California; #II(. ,. "nstrumental Methods of -nalysis; obart . Jillard; Lynne L. Merritt; Kr.; Kohn -. Dean $ @rank -. Settle; Kr.; /th edition; C2S Publishers $ Distributors; Delhi; #I)/. 0. Modern -nalytical Chemistry; D. ar5ey; Mc:ra7+ ill "nternational Ddition; Singapore; '(((.

/. @undamental of -nalytical Chemistry; D.-. Skoog; D.M. Jest and @.K. oller; / th edition; Saunders College Publishing; Ae7 Lork; #II' OC#./, Soft core paper3 A*7a* +d# a&d #%!r +d# U&+% I S%!r +d#3 "ntroduction; Structural elucidation of cholesterol; bile acids; Drgosterol and its irradiation products. Sex hormones and corticosteroids3 Synthesis of estrone; progesterone; androsterone; testosterone. 2arton reaction for the synthesis of aldosterone. 2rief discussion of homosteroids; norsteroids and oral contracepti5es. 2iological significance of anabolic steroids (14 HOURS) U&+% II A*7a* +d#3 "ntroduction; classification; isolation and general methods of structural elucidation. 2iological importance of alkaloids. Structure and synthesis of nicotine; papa5arine; Fuinine; morphine and reserpine. (14 HOURS) R!$!r!&c!# #. ". L. @inar; Organic Chemistry; DL2S Longmann; 9ol. " $ ""; #I),. '. M. -lbert; L. Lehninger; D. L. Aelson; M. M. Cox; Principles of 2iochemistry; C2E publishers; #st edition; Ae7 Delhi; #II&. &. arper!s 2iochemistry; Dd. %. arper; ''nd edition; Prentice all Press; Ae7 Lork; #II(. ,. Dncyclopedia of Chemical technology H Mirck+Othmer series 0. "ntroduction to alkaloids H :. -. S7an. /. The alkaloids+ M. J. 2ently. 1. Steroids H L. @ischer $ M. @isher. ). Steroids HShoppe Cr ## B rd!r 9a"!r OC1.?1 Ba#+c c &c!"%# +& Or.a&+c C/!0+#%r'3 >nit " -cids and bases; electrophiles and nucleophiles; hybridi<ation in carbon compounds; inducti5e effect; resonance effect; hydrogen bonding Otypes of hydrogen bonding; hydrogen bonding in @; 7ater; alcohols; acids; nitrophenols8 bond angle and bond length. 96r+$+ca%+ &3+ Crystalli<ation; sublimation; fractional crystalli<ation; distillation techniFues 6simple distillation; steam distillation; distillation under reduced pressure; fractional distillation8. S!"ara%+ & %!c/&+>6!#3+Sol5ent extraction; continuous extraction; chromatography 6principles of TLC; PC; column; :C; ion exchange chromatography8 and electrophoresis C/arac%!r+@a%+ &3 Detection of elements; estimation of carbon; hydrogen; halogens; sulphur; nitrogen and phosphourous. Detection of functional groups 6hydroxyl; carboxyl; keto; ester; amino; nitro; amide; thiol; ether etc8 in the unkno7n samples. 2asic principles for the determination of hydroxyl; carboxyl; keto; ester; amino; nitro groups. Dstimation of sugars; aminoacids and proteins. (14 HOURS) U&+% II

Ba#+c# $ r.a&+c r!ac%+ &#3+ Meaning and importance of reaction mechanism; classification and examples for each classes. S%r6c%6ra* d!%!r0+&a%+ & $ r.a&+c c 0" 6&d# by3 UV #"!c%r #c "' Habsorption maxima for simple organic moleculesG IR #"!c%r #c "' Habsorption freFuencies for functional groups in simple organic moleculesG NMR-#"!c%r #c "' H Chemical shift 6P+scale8; spin+spin coupling; coupling constants; applications to simple molecules. ?@or all spectroscopic methods; simple molecules like ethyl alcohol; methyl cyanide; ethane; propane; ethylene; ben<ene; methyl amine; aniline; acetone; acetophenone and other simple molecules are consideredB. (14 HOURS) R!$!r!&c!# #. '. ". L. @inar; Organic Chemistry; DL2S Longmann; 9ol. " $ ""; #I),. S. M. :hosh; -d5anced :eneral Organic Chemistry; 2ook and -lleied 6P8 Ltd; #II) OC 1.?2 CHEMISTRY FOR BIOLOGISTS
UNIT-I

L+$!3 Jhat is lifeQ "ts chemical definition in the perspecti5e of modern scientific progress. Or+.+& $ *+$!3 spontaneous generation of life and its failureG abiotic origin of life3 >rey+ Miller!s experiment; Oparin+ aldane concept of origin of life; panaspermic origin of life and genetic code. life material has come from extra+ terrestrial source through meteorites. Jhat is the first important polymer in the e5olution of lifeQ %A- based origin of life. Aa%!r H the ma=or constituent of life; its physical and chemical nature that makes it 5ersatile as a sol5ent. "s life possible 7ithout 7aterQ C!** H the constituent of life3 Chemical composition of the cell3 brief chemical introduction to the biopolymers like DA-; %A-; protein and polysaccharidesG important small molecules like -TP; glucose 6their structure and chemistry8. Mechanism of organic reactions that are useful in understanding chemical processes inside the cell like addition polymeri<ation 7ith the elimination of 7ater; hydrolysis of ester; Schiff!s base formation; decarboxylation reaction; transamination reaction. 314 HOURS5 UNIT-II 2asic organic chemistry concepts like nucleophilicity; electrophilicity; different types of addition; substitution and elimination reactions; kinetic isotope effects; proximity effects; stereospecificity and stereoselecti5ity. Synthetic organic chemistry as employed in biology like formation of ne7 C+C; C+A; C+O bonds etc. Chemical %ole of metal ions in the cellular processes 6like Mg'*; Ca'*; @e&*; M* and Aa*8 ? from the perspecti5e of Organic ChemistryB. Molecular en<ymology3 simple kinetics; en<yme mechanism from the perspecti5e of organic chemistry; allosterism in en<yme mechanism. Chemical basis of the biomolecular recognition3 Lock and key hypothesis and "nduced @it theory. 2asic non+co5alent forces responsible for the specificity in structure and interaction bet7een biomolecules. 2rief introduction to chemical thermodynamics and kinetics to understand the chemistry of biological processes 7ith an introduction to different methodologies to study them. Self recognition in biological

processes and chemical basis of biological self+assembly 7ith examples of nucleic acid; ribosome and chromatin. 4uantitati5e chemical and physico+chemical approaches to understand biological processes. 314 HOURS5 REFERENCES #. '. &. ,. 0. 2iochemistry + 9oet and 9oet Molecular 2iology of the cell H -lberts et al. 2iochemistry + Stryer Organic chemistry H Paula 2ruice The 2iological Chemistry of the Dlements H K. K. %. @rausto da Sil5a and %. K. P. Jilliams /. @oundations of Chemical 2iology 6Oxford Chemistry Primers8 ++ C. M. Dobson; K. -. :errard; -. K. Pratt 1. Chemical 2iology3 - Practical Course by erbert Jaldmann onors 'nd semester OC 2.1 Hard C r!- S"!c%r #c "' >nit " N6c*!ar 0a.&!%+c r!# &a&c! #"!c%r #c "'3 :eneral introduction and definition; magnetic properties of nuclei 6magnetic moment; g factor8 and theory of nuclear resonance. Larmor precession freFuency; resonance condition and relaxation processes. C/!0+ca* #/+$%3 Standards employed in AM%; factors affecting chemical shift; electronegati5ity; shielding and deshielding mechanism; 9ander 7aals deshielding; +bonding; diamagnetic and paramagnetic anisotropics. Spin+spin coupling; chemical shift 5alues and correlation for protons bonded to carbon and other nuclei. "nstrumentation and sample handling. DFui5alence and magnetic eFui5alence proton exchange reactions; effects of chiral center; complex spin+spin interaction; Marplus cur5e+5ariation of coupling constants 7ith dihedral angles. Simplification of complex spectra3 isotopic substitution; increasing magnetic field strength; double resonance; spin decoupling; constant shift reagents; sol5ent effect; @ourier+transfer techniFue; 5ariable temperature profile; nuclear o5erhauser effect 6AOD8. 314 HOURS5 U&+% II
18

C-NMR #"!c%r #c "'3 comparison of # +AM% and #&C+AM%. Multiplicity+proton decoupling; noise decoupling; off resonance decoupling; selecti5e proton decoupling; noise decoupling by @T mode; chemical shift; application of #&C+AM%. AM% of &#P and #0A. -pplication of AM%3 structural diagnosis; T( d+0!&#+ &a* NMR #"!c%r #c "' 3 COSL; AODSL; "ADO% and SP"; DDPT spectra. C"DAP techniFues and magnetic resonance imaging 6M%"8. C 0" #+%! "r )*!0# Problems in5ol5ing the application of the abo5e spectroscopic techniFues for structural elucidation of organic molecules. 314 HOURS5 R!$!r!&c!#

#. Spectroscopy by 2. P. Straughan and S. Jalker; Kohn Jiley $ Sons "nc.; Ae7 Lork; 9ol. '; #I1/. '. Organic spectroscopy by Jilliam Memp; DL2S Society; MacMillan; #I)1. &. -pplication of absorption spectroscopy of organic compounds by Kohn %. Dyer; Prentic+ all of "ndia Pri5ate Ltd.; Ae7 Delhi; #I1,. ,. Organic spectroscopy by 9. %. Dhani; Tata Mc:ro7+ all publishing company Ltd.; Ae7 Delhi; #II0. 0. 2. P. Straughan; S. Jalker; Chapman and all; Kohn Jiley $ Sons "nc.; Ae7 Lork; 9ol. #; #I1/. /. Spectrometric identification of organic compounds; ,th edition; %obert M. Sil5erstein; :. Clayton 2assler and Terence C. Morrill; Kohn Jiley $ Sons "nc.; Ae7 Lork; 9ol. #; #I)#. 1. "nterpretation of carbon+#& AM% spectra; @. J. Jehrli and T. Jirthlin; eyden; London; #I1/. OC 2.2 Hard C r!- R!a.!&%# B S'&%/!#+# U&+% I 9r %!c%+&. .r 6"#3 protection of hydroxyl; carboxyl; carbonyl; thiol; amino groups;. "llustration of protection and deprotection in synthesis. @unctional group transformations R!a.!&%# +& r.a&+c #'&%/!#+#3 >se of follo7ing reagents in organic synthesis and functional group transformations3 dicyclohexyl carbodiimide; DD4; trimethyl silyl halides; trimethyl silyl cyanide; T2DMS+chloride; phase transfer catalyst; chiral PTC; cro7n ethers; cyclodextrins; mercuric acetate; nickel chloride; -luminium oxide; @enton!s reagent; 2aker!s yeast; dia<omethane; stannous chloride; La7esson reagent and thiourea. Na0! r!ac%+ &#3 Sharpless epoxidation; Sharpless dihydroxylation and aminohydroxylation; Jood7ard and PrR5ost hydroxylation; Mitshinobou reaction; Aormant reaction 6E selecti5e alkene synthesis8; Aoyori catalyst; olefin metathesis; -symmetric hydrogenation; asymmetric hydroxylation using chiral oxa<olidone.. Click chemistry 6drug deli5ery system83 ?#/ hrsB UNIT II 9*a&&+&. a&d E<!c6%+ & $ M6*%+#%!" S'&%/!#+# 2asic principles and technologies used in disconnection approach; synthons and synthetic eFui5alents; "ntercon5ersion of functional groups; one group C+S and t7o group C+S disconnections. Protecting groups+Principles of protection of hydroxyl; amino; carboxylic and carbonyl groups. >se of C+C one group and C+C t7o group disconnections in the synthesis of #;'G #;&G #;,G #;0 and #;/+difunctionalised compounds. %etrosynthetic analysis of alcohols; carbonyl compounds; cyclic and acyclic alkanes; ben<ocaine; p+methoxyacetophenone; acetocyanohydrin; '+methyl+/+methoxy+indole+&+acetic acid; /+ methylFuinoline. "llustrati5e synthesis of Ku5abione; Longifolene; Prelog+D=erassi lactone; Taxol and Dpothilone -. Solid phase synthesis of polypeptides and oligonucleotides. ?#/ hrsB UNIT IIIA#'00!%r+c #'&%/!#+#3 Definition; importance; mechanism; energy consideration; ad5antages and limitations; methods of determination of enantiomeric excess.

i. T " c+%' - 9r c/+ra*+%'+ Substrate selecti5ity + Diastereoselecti5ity and enantio+selecti5ity+ Substrate controlled methods+use of chiral substrates + examples ii. A6<+*+ar' c &%r **!d 0!%/ d#+ >se of chiral auxiliaries+Chiral enolates+alkylation of chiral imines + -symmetric Diels + -lder reaction R!a.!&% c &%r **!d 0!%/ d#+ >se of chiral reagents + -symmetric oxidation HSharpless epoxidation + -symmetric reduction + >se of lithium aluminium hydride and borate reagents. Synthesis and applications of oxa<aborolidines; "PC+22A; "PC '2 ; 6S8+2"A-P+D"-M"AD and 6%8+2"A-L+ . >se of 6%;%8+D"P-MP; 6S;S8+C "%-P OS; 6%;%8+D"OP; S-MP; %-MP; S+ Proline; S+P2MgCl; 6+8+2O-lCl'; 6*8 and 6+8+DDT. %eferences3 a. Organic Synthesis+Special TechniFues; 9.M.-hlu7alia and %. -ggar7al; Aarosa; Ae7 Delhi; '((#. b. Organic Synthesis; %.D."reland; Prentice all "ndia; #I/I. c. -d5anced Organic Chemistry; "9 Dd.; Part - $2; @.K.Carrey $ %.K.Sundberg; Mlu7er; '((#. d. Organic Synthesis+ - Disconnection -pproach; Stuart e. -rt in Organic Synthesis; -nand; 2indra $ %anganath; Jiley; Ae7 Delhi; #I1(. f. Modern Methods of Organic Synthesis; A. Carruthers; Cambridge >ni5ersity; #II/. g. Organic %eaction Mechanisms; 9.M.-hlu7alia $ %.M.Parashar; Aarosa; '((/ h. Stereochemistry+ Conformation and Mechanism; P.S.Malsi; Jiley Dastern; Ae7 Delhi; #II&. i. Stereochemistry of Carbon Compounds; D. L. Dlliel; Tata Mc:ra7 ill; Ae7 Delhi; #II,. =. Organic chemistry; K. Clayden; A. :ree5es; S. Jarren $ P. Jothers; Oxford >ni5ersity Press. ?#/ hrsB OC2.8 Hard C r! C r!- 9r+&c+"*!# $ 9/'#+ca* C/!0+#%r' U&+% I C &c!"%# $ !&%r "' a&d $r!! !&!r.' 3 Dntropy as a measure of una5ailable energy. Dntropy change during spontaneous process. elmholt< and :ibbs free energies. Thermodynamic criteria of eFuilibrium and spontaneity. 9ariation of free energy 7ith temperature and pressure. Max7ell!s relations. 9on!t off!s reaction isotherm and isochore; :ibbs+ elmholt< eFuation. Determination of free energy changes. Aernst heat theorm and "; "" $ """ la7 of thermodynamics H calculation of absolute entropies. 9ar%+a* 0 *ar "r "!r%+!#3 Partial molar 5olumes and their determination by density measurements. Chemical potential and its significance. 9ariation of chemical potential 7ith temperature and pressure. Principles of :ibbs+Duhem eFuation and de5iation of Duhem+Margules eFuation. F6.ac+%'- Determination of fugacity of gases. 9ariation of fugacity 7ith temperature and pressure. -cti5ity and acti5ity coefficients. 9ariation of acti5ity 7ith temperature and pressure. Determination of acti5ity coefficients by 5apour pressure; depression in free<ing point; solubility measurements and by electrical methods. 314 HOURS5

U&+% II Chemical Minetics3 Parallel; consecuti5e and re5ersible reactions. -rrehenius eFuation; energy of acti5ation and its experimental determination. Simple collision theory+mechanism of bimolecular reaction. Lindemann!s theory for unimolecular reaction. -cti5ated complex theory of reaction rate; classical thermodynamic treatment; partition function; statistical thermodynamic treatment. Minetics of reactions in solution3+ Collision theory and the acti5ated complex theory. Salt effect; effect of dielectric constant 6single sphere and double sphere model8; effect of pressure; 5olume and entropy change on reaction rates. Cage effect 7ith an example. Minetics of heterogeneous reactions3 + Langmuir!s theory; unimolecular and bimolecular surface reactions. @ast reaction kinetics3 @lo7 method; relaxation method 6@lash photolysis; pulse radiolysis; Shock tube method8. 314 HOURS5 %eferences #. '. &. ,. 0. /. 1. ). I. #(. Thermodynamics for chemists by S. :lasstone; -ffiliated Dast+Jest press; Ae7 Delhi 6#I/08 Chemical thermodynamics by ". M. Molt<; J. -. 2en<amin "nc. Ae7 Lork; -msterdam 6#I/,8 2asic Physical Chemistry by J. K. Moore; Prentic all of "ndia P5t. Ltd.; Ae7 Delhi 6#I)/8 Text book of Physical Chemistry by S. :lasstone; McMillan "ndian Ltd.; 6"" edition8; 6#I1,8 Chemical kinetics by M. K. Laidler Chemical kinetics by @rost and Pearson Chemical kinetics by L. M. Kain Chemical kinetics by 2enson Dlements of Physical Chemistry by Le7is and :lasstone Physical Chemistry by P.J. -tkins; DL2S; ,th Ddition; Oxford >ni5ersity Press 6#II(8.
?/( hrsB

OC2.: Hard C r!- Or.a&+c C/!0+#%r' 9rac%+ca* 1 ,6a*+%a%+2! a&a*'#+#

,6a*+%a%+2! a&a*'#+#- Separation of binary mixtures; identification of functional groups and preparation of suitable solid deri5ati5es. R!$!r!&c!#. '. &. ,. - Text book of practical organic chemistry H -. ". 9ogel 9ol. ". Semimicro Fualitati5e organic analysis by Cheronis; Dntrikin and odnet. K. A. :uthru $ %. Mapoor; -d5ance experimental chemistry; S. Chand Company; Ae7 Delhi; #II#. %. M. 2ansal; Laboratory Manual of Organic Chemistry; Ae7 P:D "nternational 6P8 Ltd. London; &rd edition; #II/. OC2.= Hard C r!- Or.a&+c C/!0+#%r' 9rac%+ca* 1 I# *a%+ & $ &a%6ra* "r d6c%#
?/( hrsB

#.

@ractional crystalli<ation3 separation of mixture of naphthalene and biphenyl

'. &. ,. 0. /. 1. ). I. #(. ##. #'. #&. #,.

@ractional distillation3 Separation of mixture of hexane and toluene. -<eotropic distillation and remo5al of 7ater. Thin layer chromatography3 Separation of plant pigments Column chromatography3 Separation of mixture of o $ p+nitro anilines Paper chromatography3 Separation of amino acids "solation of piperine from pepper "solation of caffeine from tea "solation of cysteine from hair "solation of hesperidiene from orange peal "solation of a<eleic acid from castor oil "solation and spectroscopic characteri<ation of Lycopene "solation of lipids from egg yolks Dxtraction of nicotine from Tobacco Lea5es

%eferences #. '. &. Manual of Organic Chemistry H Dey and Seetharaman Aatural Products Chemistry by %aphel "khan Modern experimental organic chemistry by Kohn . Miller and D. @. Aeugil; p ')I. OC './# Soft Core3 9r+&c+"*!# $ A&a*'%+ca* C/!0+#%r' U&+% I S%a%+#%+ca* %r!a%0!&% $ a&a*'%+ca* da%a3 Types of errors+ determinate and indeterminate errors; accuracy and precision; distribution of random errors+freFuency distributions; the normal error cur5e; statistical treatment of finite samples; measures of central tendency H mean; median; measure of 5ariability; range; a5erage de5iation; relati5e a5erage de5iation; standard de5iation and 5ariance; testing for significance H comparison of t7o means and t7o standard de5iations; criteria for re=ection of an obser5ation H 4 test; control charts; propagation of errors; figures; least sFuare method of deri5ing calibration plots; correlation coefficient. 9r+&c+"*!# $ #a0"*+&.3 The sampling step; methods for sampling of solid; liFuid and gaseous samples; effects of sampling uncertainties; sampling ha<ards. U&+% II Hard a&d # $% ac+d# a&d )a#!#. Lux+@lood and >sano5ich concepts; sol5ent system and le5eling effect. ard HSoft -cids and 2ases Classification and Theoretical backgrounds. Ac+d )a#! %+%ra%+ &#3 Principles of titrimetric analysis; titration cur5es for strong acid+strong base; 7eak acid+strong base and 7eak base+strong acid titrations; polyprotic acids; poly eFui5alent bases; determining the eFui5alence point+theory of acid base indicators; colour change range of indicator; selection of proper indicator; indicator errors; feasibility of acid+base titrations+ magnitude of the eFuilibrium constant; effect of concentration. A""*+ca%+ &# $ ac+d-)a#! %+%ra%+ &#3 Determination of nitrogen; sulphur; ammonium salts; nitrates and nitrites; carbonates and bicarbonates and organic functional groups like carboxylic acid; sulphonic acid; amines; ester; hydroxyl; carbonyl group; air pollutants like SO'. Ac+d-)a#! %+%ra%+ &# +& & &-a>6! 6# # *2!&%# 3 Sol5ents for non+aFueous titrations; characteristics of amphiphilic sol5ents+autoprotolysis; dielectric constant; meaning of p ; aprotic sol5ents; choosing a sol5ent; some selected sol5ents; titrant and standards; titration cur5es; effect

of 7ater; determining the eFui5alence point; typical applications3 determination of carboxylic acids; phenols and amines. 314 HOURS5 R!$!r!&c! ) 7#3 #. -nalytical Chemistry; :.D. Christian; 0th ed.; Kohn Jiley $ Sons; "nc; "ndia; '((#. '. 9ogel!s Textbook of 4uantitati5e Chemical -nalysis; K. Mendham; %.C. Denney; K.D. 2arnes and M.K.M. Thomas; /th edition; Pearson Dducation P5t. Ltd.; Ae7 Delhi; '((,. &. -nalytical Chemistry Principles; Kohn . Mennedy; 'nd edition; Saunders College Publishing; California; #II(. ,. "nstrumental Methods of -nalysis; obart . Jillard; Lynne L. Merritt; Kr.; Kohn -. Dean $ @rank -. Settle; Kr.; /th edition; C2S Publishers $ Distributors; Delhi; #I)/. 0. Modern -nalytical Chemistry; D. ar5ey; Mc:ra7+ ill "nternational Ddition; Singapore; '(((. /. @undamental of -nalytical Chemistry; D.-. Skoog; D.M. Jest and @.K. oller; / th edition; Saunders College Publishing; Ae7 Lork; #II' OC2.42 S $% C r!- L+"+d# a&d V+%a0+&# U&+% I L+"+d#3 Aomenclature; classification; purification; structure and synthesis of fatty acids; phospholipids; sphingolipids. 2iological importance of lipids 6Lecithin; sphingolipids; oils and fats8. 9r #%a.*a&d+&#3 "ntroduction; classification and biological importance of P:!s. Constitution of P:D#. Synthesis of P:D $ @ series. T!r"!& +d#3 "ntroduction; classification and general methods of structural elucidation. 2iological importance of terpenoids. Chemistry of pinene; camphor; caryophyllene; santonin; abietic acid and 5eti5one. (14 HOURS) U&+% II V+%a0+&#3 "ntroduction; constitution; synthesis and biological significance of thiamine; ribofla5in; pyridoxine; biotin; ascorbic acid; 5itamin -; D and M groups. (14 HOURS) R!$!r!&c!# #. '. &. ,. 0. ". L. @inar; Organic Chemistry; DL2S Longmann; 9ol. " $ ""; #I),. M. -lbert; L. Lehninger; D. L. Aelson; M. M. Cox; Principles of 2iochemistry; C2E publishers; #st edition; Ae7 Delhi; #II&. arper!s 2iochemistry; Dd. %. arper; ''nd edition; Prentice all Press; Ae7 Lork; #II(. Dncyclopedia of Chemical technology H Mirck+Othmer series arper!s re5ie7 of biochemistry H P. J. Martin; P. -. Mayer $ 9. J. %odf7ell; 0th edition; Maur<en -sian Ddition; California; #I)#. OC2.48 S $% c r!- H!%!r c'c*+c c/!0+#%r'

U&+% I Aomenclature of heterocyclic systemsG Structure; reacti5ity; synthesis and reactions of furan; pyrrole; thiophene; indole; pyridine; Fuinoline; isoFuinoline; pyra<ole; imida<ole; pyrone; coumarin; chromones; pyrimidines and purines. (14 HOURS) U&+% II Synthesis and synthetic applications of a<irines $ a<iridines; oxa<olines; isoxa<olines; isoxa<ole; oxa<ines; di<ines; tria<ole and a<epines and ben<odia<epines. "ntercon5ersion of furan to pyra<ole; pyrrole to pyridine; pyra<ole to pyridine; "satin to Fuinoline; furans to pyridines. >ses of heterocycles in the synthesis of nonheterocycles. (14 HOURS) %eferences3 #. '. &. ,. eterocyclic Chemistry HKoule $ Smith eterocyclic chemistry H -chaeson 2asic Principles of heterocyclic chemistry H L. -. PacFuette Comprehensi5e heterocyclic chemistry HMartrit<ky series; Pergamon Press; Ae7 Lork; #I),. OC2.4: S $% C r!- M!d+c+&a* c/!0+#%r'-I :eneral pharmacological principles3 Definitions of3 pharmacology; pharmadynamics; pharmakinetics; pharmatherapeutics; chemotherapy $ toxicology. %outes of drug administration; factors affecting choice of routes. -dsorption; distribution and excretion of drugs. @actors modifying drug action; drug ad5erse effects. -ntimicrobial drugs3 Classification 7ith example; problems that arose in the antimicrobials. Sulphonamides3 Mechanism of action; resistance to sulphonamides; examples and uses of any three sulphonamides. 2etalactum antibiotics; Pencillin :; chloramphinicol; mode of action; ad5erse effects. Drugs on gastro intestinal tract3 Drugs for peptic ulcer+ approaches for the treatment; # receptor antagonists and proton pump inhibitors; antacids; systemic and non+systamic antacids; role of antacid in peptic ulcer. Mechanism of drug absorption; passi5e diffusion; acti5e transport; connecti5e adsorption; ion+pair adsorption. Polymorphism in drug molecule and effect on drug adsorption. Purgati5es H classification; examples and uses; mechanism of action; dangers of purgati5es abuse. Drugs acting on ner5ous systems3 ypnotics and sedati5es+ definition; classification 7ith examples. 2arbiturates+pharmalogical action; pharmacokinetics; ad5erse effects and treatment. Salicylates+pharmcological action; ad5erse effects. Paracetamol+ action; toxicity. Opiod analgesics+examples. Morphine+ pharmacological action; ad5erse effects and precautions. Local anaesthetics3 Definition; classification; mechanism of action; local action; systemic action; pharmacokinetics; ad5erse effects and techniFues of local anesthetics. Cocaine and its deri5ati5es.

:eneral anesthetics+ Properties of ideal anesthetics; classification; properties of A'O; Complications of anesthetics. Dthyl alcohol3 pharmacological action; pharmacokinetics; food 5alues; clinical use; contradictions; toxicity. R!$!r!&c!#G #. '. &. ,. 0. /. 1. ). I. #(. ##. "ntroduction to medicinal chemistry; - :ringuage; Jiley+9C . Jilson and :is5oldTs Text 2ook of organic medicinal and pharmaceutical chemistry; Dd %obert @. Dorge. -n introduction to drug design; S.S. Pandey and K.%. Dimmock; Ae7 -ge "nternational. 2urgerTs medicinal chemistry and drug disco5ery; 9ol+# 6Chapter+I and Ch+#,8; Dd. M.D. Jolff; Kohn Jiley. :oodman and :ilmanTs pharmacological basis of therapeutics; Mc:ra7+ ill. The organic chemistry of drug design and drug action; %. 2. Sil5erman; -cademic Press. Strategies for organic drug synthesis and design; D. Lednicer; Kohn Jiley. Medicinal Chemistry; - Mar; Jiley; '(((. Synthetic drugs; :. %. Chat7al; imalaya; Ae7 Delhi; #II0. Comprehensi5e organic chemistry; 9ol. 0 6-ntibiotics8; D. .%. 2arton; J. D. Ollis; Pergamon Press; AL; #I1I. "nstant Aotes Medicinal Chemistry; P :raham; 9i5a; Ae7 Delhi; '(('. Cross 2order Paper3 OC2.?1 C/!0+#%r' $ &a%6ra* "r d6c%# Fa%# a&d +*#- "solation; purification; structure and biological importance. E##!&%+a* +*#3 Source; constituents; isolation $ uses. 9/ #"/ *+"+d#3 "solation; structure and biological significance of lecithin and cephalin S"/+&. *+"+d#3 Dxamples 7ith structure and biological importance. 9r #%a.*a&d+&#3 Classification; source; structure; nomenclature and its significance. T!r"!& +d#3 "ntroduction; classification; source; structure of biologically important terpenoids 6antihelmentic; anticancer terpenoids; etc8 S%!r +d#3 Structure and biological significance of cholesterol; bile acids; androgen; estrone; progesterone and anabolic steroids. Flavonoids and Isoflavonoids: Occurrence; nomenclature; structure and their biological importance. 9 r"/'r+&#3 "ntroduction; structure and biological functions of haemin. 9itamin 2 #' 3 structure and as coen<yme in molecular rearrangement reactionsG Chlorophyll3 structure and biological importance. Car %!& +d#3 Methods of isolation; structure and their biological importance.. A*7a* +d#3 "ntroduction; source; structure and biological significance of 5inca alkaloids; chincona alkaloids; LSD; reserpine; morphine; codeine; strychnine; brucine; nicotine; yohimbine; V+%a0+&#3 structure and biological functions of 5itamin -; C; D; D; M; biotin; pyridoxine; thiamine. ?&' hrsB R!$!r!&c!# #. ". L. @inar; Organic Chemistry; DL2S Longmann; 9ol. " $ ""; #I),. ' Dssentials of physiological chemistry H -nderson; Kohn Jiley $ Sons; Ae7 Lork; #I0&.

& , 0 /

M. -lbert; L. Lehninger; D. L. Aelson; M. M. Cox; Principles of 2iochemistry; C2E publishers; #st edition; Ae7 Delhi; #II&. arper!s 2iochemistry; Dd. %. arper; ''nd edition; Prentice all Press; Ae7 Lork; #II(. Dncyclopedia of Chemical technology H Mirck+Othmer series arper!s re5ie7 of biochemistry H P. J. Martin; P. -. Mayer $ 9. J. %odf7ell; #0th edition; Maur<en -sian Ddition; California; #I)#. OC 2.?2 MATERIAL CHEMISTRY UNIT I

M!%a* Car)+d!#3 Salt+like; co5alent and interstitial carbides. "ntercalation compounds of graphite; alkali metals. "ndustrially important reactions of oxides 7ith carbon. S+*+c &! " *'0!r#3 "ntroduction; nature of chemical bonds containing silicon; general methods of preparation 6fluids and resins8 and properties of silicones. -pplications. "ndustrial uses of silicon; silicon carbide and silicon dioxide. M+caC C*a' a&d @! *+%!# H Structures and applications. >ses of asbestos. -luminium alloys+>ses. C/!0+ca* r!ac%+2+%' a&d .r 6" %r!&d# $ .!r0a&+60C %+& a&d *!ad H -pplications. Metallic tin and alloys; lead alloys and oxides of lead. 314 HOURS5 UNIT II 9!%r c/!0+ca*#3 Petroleum refining; constituents of petroleum and their separation. Con5ersion processes 6cracking; reforming; alkylation etc8 for precursors of petrochemicals. 2rief description of the chemistry of manufacture of methane; ethane; ethylene; propylene; butylenes; acetylenes; ben<ene and some of its deri5ati5es and their con5ersion to some useful products. I&#!c%+c+d!#3 "ntroduction; classification; mode of action and synthesis of chlorinated insecticides 6DDT; chlordane; heptachlor and hexachlorocyclohexane8. Organophosphorous insecticides3 Malathion; parathion; DD9P; dia<enon. Carbamate insecticides3 Se5in; carbofluron; aldicab; beygon. "nsect Pheromones3 "ntroduction; classification; use in insect pest control. (14 HOURS) REFERENCES #. Chemistry of the elements H A.A. :reen7ood and -. Darnsha7; Pergamon press; #I)0 '. "norganic chemistry H K.D. uheey. &. "norganic polymers H :.%. Chat7al; imalaya Publishing ouse; Ae7 Delhi. ,. Solid state chemistry and its applications+ -.%.Jest. Kohn Jiley and Sons. 0. Chemistry of pesticides H Melniko5 /. Dncyclopedia of Chemical technology H Mirck+Othmer series Masters " Semester OC&.# ard Core3 Molecular rearrangements and :reen chemistry

U&+% I M *!c6*ar r!arra&.!0!&%#3 "ntroduction; Car) & % car) & 0+.ra%+ &#3 Pinacol+pinacolone; Jagner+Meer7ein; 2en<idine; Demyano5; 2en<ylic acid; @a5orskii; -rndt+Distert synthesis; @ries rearrangement; Ste5ens rearrangement. Car) &-% &+%r .!& 0+.ra%+ &#3 ofmann; Curtius; Lossen; Schmidt and 2eckmann rearrangement. M+#c!**a&! 6# r!arra&.!0!&%3 Sommelet+ auser; Jittig; Smiles; Aeber; %upe; Kap+ Mlingermann rearrangement; Meisenheimer rearrangements; 2ayer+9illeger rearrangement. -llylic rearrangements. ?#/ hrsB U&+% II ?#/ hrsB Gr!!& C/!0+#%r' Definition and principles; planning a green synthesis in a chemical laboratory; :reen preparation+ -Fueous phase reactions; solid state 6sol5ent less8 reactions; photochemical reactions; Phase transfer catalyst cataly<ed reactions; en<ymatic transformations $ reactions in ionic liFuids. Micro7a5e induced organic synthesis3 "ntroduction; reaction 5essel and reaction medium; concept; specific effect; atom efficiency; U atom utili<ation; ad5antages and limitations; A+ alkylation and alkylation of acti5e methylene compounds 7ith aldehydes; synthesis of "buprofen by 2 C and 2OOTS approaches; Diels+-lder reaction; Leuckardt reducti5e amination of ketones; oxidation of alcohols and sulfides. Organic process research; process de5elopment; process optimi<ation. 2asics of en5ironmental health safety; basics of intellectual property rights. (14 HOURS) R!$!r!&c!##. '. &. ,. 0. /. 1. ). I. #(. K. March; -d5anced Organic Chemistry; Jilley "nterscience; #II,. @. -. Carey and Sundberg; -d5anced Organic Chemistry H Part - $ 2; &rd edition; Plenum Press; Ae7 Lork; #II(. Comprehensi5e Organic Chemistry; Pergamon Press; Ae7 Lork; 9ol #; #II/; . Pine; endrickson; Cram and ammond; Organic Chemistry; Mac :ro7 ill; Ae7 Lork; #I)1. ". ". @inar; Organic Chemistry; DL2S Longmann; 9ol. " $ ""; #I), @. -. Carey and Sundberg; -d5anced Organic Chemistry H Part - $ 2; &rd edition; Plenum Press; Ae7 Lork; #II( Comprehensi5e Organic Synthesis H 2. M. Trost and ". @leming series; Pergamon Press; Ae7 Lork; #II#. S. M. :hosh; -d5anced :eneral Organic Chemistry; 2ook and -lleied 6P8 Ltd; #II) :reen Chemistry+Dn5ironment friendly alternati5es; %.Sanghi $ M.M.Sri5atsa5a; Aarosa; '((&. :reen Chemistry+Dn5ironment benign reactions; 9.M.-hlu7alia; -ne 2ooks "ndia; '((/. OC8.2 Hard C r!- B &d+&.C 9/ % c/!0+#%r' a&d 9!r+c'c*+c r!ac%+ &#

U&+% I B &d+&. +& r.a&+c #'#%!0#3 Theories of bonding+ 9alence and molecular orbital approaches. uckel molecular orbital theory and its application to simple +systems3 ethylene; allyl; cyclopropyl; butadienyl; cyclopentadienyl; pentadienyl; hexatrienyl; cyclohexatrienyl; heptatrienyl; cycloheptatrienyl systems. Calculation of the total +energy; delocali<ation energy; bond order and M.O. coefficients of the systems. Ar 0a%+c+%'3 Concept of aromaticity; uckel!s rule; Polygon rule; annulenes; heteroannulenes and polycyclic systems. -romaticity and bonding in fullerenes. 314 HOURS5 U&+% II 9/ % c/!0+#%r'- :eneral consideration3 -cti5ation in thermal and photochemical reactions. Light absorption and excitation. Singlet and triplet states. Morse cur5e; @ranck+Condon principle. Deexcitation3 Physical process; Kablonski diagram. Photosensiti<ation 6donor acceptor concept; resonance and collision transfer8. Chemical process; Fuantum efficiency; Fuantum and chemical yields. Photochemistry of functional groups3 i8 Olefins3 Cis-trans isomerism; ?'*'B cycloaddition; rearrangements. %eaction of con=ugated olefinsG di++methane rearrangement. ii8 Ketones3 Dxcited state of CCO. Aorrish type+" and type+"" clea5ages. Paterno+2uchi reaction. ;+unsaturated ketones. ?'*'B addition; cis-trans isomerisation. %earrangements of cyclohexadienones. iii8 Aromatic compounds3 Photorearrangement of ben<ene and its deri5ati5es; cycloaddition of ben<ene. i58 Photochemical oxidations and reductions3 Cycloaddition of singlet molecular oxygen. Oxidati5e coupling of aromatic compounds; photoreduction by hydrogen absorptions. 9/ % d!.rada%+ &3 Photocatalyst HEnO; TiO'; principle; application of EnO.TiO' in the phodegradation of dyes 6"C8; pesticides 6DDT; CC ( and in industrial affluents. Dffect of photodegradation on COD 5alues. (14 HOURS) >nit """ 9!r+c'c*+c r!ac%+ &#- Classification of pericyclic reactions. Molecular orbital symmetry; @rontier orbitals of ethylene; #;&+butadiene; #;&;0+hexatriene and allyl system. E*!c%r c'c*+c r!ac%+ &#3 Jood7ard+ ofmann rules for electrocyclic reactions; @MO theory of electrocyclic reactions; correlation diagram for cyclobutadiene and cyclohexadiene systems. C'c* add+%+ & r!ac%+ &#3 ?'*'B; ?&*'B and ?,*'B cycloadditions; analysis by @MO and correlation diagram method. Cycloadditions + antarafacial and suprafacial additions; ?'*'B additions of ketenes. 1C8-d+" *ar c'c* add+%+ &#3 in5ol5ing nitrile oxide; nitrile imine; nitrile ylide cycloaddition. "ntra and intermolecular &*' cycloaddition and their application in organic synthesis. 3:D25 c'c* add+%+ & r!ac%+ &#3 Deil!s+-lder reaction; hetero Diel!s+-lder reaction and their applications.

S+.0a%r "+c r!arra&.!0!&%# + Classification; stereochemistry and mechanisms. suprafacial and antarafacial shifts of ; sigmatropic shifts in5ol5ing carbon moieties. ?&;&B+ and ?0;0B+ sigmatropic rearrangement; Claisen; Cope and a<a+Cope rearrangements. C/!* %r "+c r!ac%+ &#3 (14 HOURS) R!$!r!&c! ) 7# #. '. &. , 0. / 1. ). @. -. Carey and Sundberg; -d5anced Organic Chemistry H Part - $ 2; &rd edition; Plenum Press; Ae7 Lork; #II(. Dupey and Chapmann; Molecular reactions and Photochemistry; Prentic all+ "nternational; Tokyo; #I1'. "ntroduction to physical organic chemistry H Moso7er Molecular orbital calculations H K. D. %oberts A. K. Turro; Modern molecular photochemistry; The 2en<amin Cummings Publishing Co. Ltd; Menlo Park; #I1). M. Lates; uckel!s Molecular Orbital Theory; -cademic Press; Ae7 Lork; #I1). T. L. :ilchrist $ %. C. Storr; Organic reaction and orbital symmetry; Cambridge >ni5. Press; London; #I1I. D. C. Aeckers; Mechanistic Organic Photochemistry; %einhold; Ae7 Lork; #I/1. OC8.8 Hard c r!- Or.a& 0!%a**+c# a&d r.a& & &0!%a**+c# >nit " Or.a& ) r & c 0" 6&d#3 "ntroduction and preparations. ydroboration and its applications. Reactions of organoboranes3 isomeri<ation reactions; oxidation; protonolysis; carbonylation; cyanidation. Reaction of nonallylic boron stabilized carbanions3 -lkylation reactions; -cylation reaction; %eactions 7ith aldehydes or ketones 6D and E+alkenes8. Or.a& #6*"/6r c 0" 6&d#3 "ntroduction. Preparations; reactions; mechanism and synthetic applications of important sulphur containing reagents like dithiane; sulphur ylides etc. Or.a& #+*+c & c 0" 6&d#3 "ntroduction; preparations and reactions; Peterson reaction. Or.a& "/ #"/ r 6# c 0" 6&d#3 Aomenclature; synthesis and reactions of trialkyl phosphine; triarylphosphine; trialkyl phosphite; triaryl phosphite; trialkyl phosphate; triaryl phosphates. Jittig reaction and Jittig+ orner reactions3 + mechanisms and synthetic uses. -rbaso5 reaction; transesterification. Organofluorine compounds (14 HOURS) U&+% II C/!0+#%r' $ r.a& 0!%a**+c c 0" 6&d#3 Synthesis and reactions of organolithium 6n+2uLi; PhLiV; organocadmium; organomagnesium 6:rignard reagent8; organomanganese; organoselenium and organotellurium. Or.a& a*60+&+60 r!a.!&%#3 Preparation; site selecti5e and stereoselcti5e additions of nucleophiles mediated by organoaluminum reagents; reaction 7ith acid chlorides; allyl 5inyl ethers; #;'+addition to imines and application in the synthesis of natural products.

Or.a& c ""!r r!a.!&%#3 :ilman reagent; preparation; reactions 7ith aldehydes; ketones and imines. -pplication in the synthesis of bre5icomin; Or.a& "a**ad+60 c 0" 6&d#3 Su<uki coupling; eck reaction. Or.a& @+&c r!a.!&%#3 Preparation + oxidati5e addition and transmetallation; addition reactions of alkyl; aryl; allylic and propargylic <inc reagents; diastereoselecti5e and enantioselecti5e addition reaction 7ith aldehydes; %eformatsky reaction. Or.a& #a0ar+60 r!a.!&%#3 %eactions promoted by samarium diiodide and dicyclopentadienyl samarium H 2arbier type reaction; %eformatsky type reactions; ketyl+alkene coupling reactions; pinacolic coupling reactions; acyl anion reactions. Or.a& %+& r!a.!&%#3 tributyltin hydride; 2arton decarboxylation reaction; 2arton deoxygenation reaction; Stille coupling; Stille+Melley coupling reactions; 2arton McCombie reaction; Meck stereoselecti5e allylation and other applications. (14 HOURS) R!$!r!&c!##. K. March; -d5anced Organic Chemistry; Jilley "nterscience; #II,. '. @. -. Carey and Sundberg; -d5anced Organic Chemistry H Part - $ 2; &rd edition; Plenum Press; Ae7 Lork; #II(. &. Comprehensi5e Organic Chemistry; Pergamon Press; Ae7 Lork; 9ol #; #II/; ,. Comprehensi5e Organic Synthesis H 2. M. Trost and ". @leming series; Pergamon Press; Ae7 Lork; #II#. 0. S. M. :hosh; -d5anced :eneral Organic Chemistry; 2ook and -lleied 6P8 Ltd; #II) OC8.: Hard C r!- M6*%' #%!" #'&%/!#+#
?/( hrsB

Oxidation of alcohols3 Oxidation of cyclohexanol to adipic acid 5ia cyclohexanone #. Dsterification3 Preparation of ben<occaine from p+nitrotoluene '. Dia<oti<ation 6Sandmeyer!s reaction83 Preparation of p+chloroben<oic acid from p+ toluidine &. Molecular rearrangement3 i. Preparation of o+chloroben<oic acid from phthalic anhydride ii. Preparation ben<ilic acid from ben<aldehyde iii. Preparation of o+hydroxy ben<ophenone 5ia @ries rearrangment i5. Prepartion of ben<anilide from ben<ophenone oxime. ,. :rignard reaction3 Prepearation of triphenyl carbinol 0. Preparation of luminol from phthalic anhydride /. Preparation of paracetomol. 1. Synthesis of isoxa<olines and pyra<olines 5ia #;&+dipolar cycloadditions. ). Synthesis of malemides and pthalimides using micro7a5e techniFues I. Synthesis of ben<ophenone deri5ati5es 5ia @ries rearrangement. #(. Sol5othermal synthesis ##. Synthesis of tetralones starting from aryl aldehydes. #'. Synthesis of metachloroiodoben<ene from dinitroben<ene OC&.0 ard core3 4uantitati5e anaylsis #. '. DFui5alent 7eight of acids by sil5er salt method "odine 5alue of an oil and fats by chloramine+T
?/( hrsB

&. ,. 0. /. 1. ). I. #(. ##. #'.

Saponification 5alue of an oil or fats Dstimation of sugars by @ehlings method Determination of enol content by Meyer!s method Determination hydroxyl groups Determination of 5icinal hydroxyl groups Dstimation of ketones by haloform reaction Dstimation of sugars by 2ertrand!s method Dstimation of nitro groups Dstimation of amino acids Dstimation of ketones by oxime method R!$!r!&c! B 7#-

#. '. &. ,. 0. /. 1.

- Text book of practical organic chemistry H -. ". 9ogel 9ol. " Practical Organic Chemistry H Mann $ Saunders Manual of Organic Chemistry H Dey and Seetharaman -n introduction to practical organic chemistry H %obert; 9ingro5e etc. Semimicro Fualitati5e organic analysis by Cheronis; Dntrikin and odnet %. M. 2ansal; Laboratory Manual of Organic Chemistry; Ae7 -:D "nternational 6P8 Ltd. London; &rd edition; #II/ A. M. 9isno; Practical Organic Chemistry; Ae7 -:D "nternational 6P8 Ltd. London; &rd edition; #II/ OC8.41 S $% C r!- 9/'#+ca* C/!0+#%r' UNIT-I

ENEYME FINETICSDffect of substrate concentration; Dffect of p ; effect of catalysts and inhibitors 6substrate; <eoliter; Cr&*; @e'* EnO; >.9 light8 and effect of temperature. - brief kinetic and mechanistic applications of glucose oxidase and L+amino oxidase in the oxidation of glucose and L+amino acids. 2iological significance of Donnan membrane phenomenon. Micelles and in5ol5ement during digestion and absorption of dietary lipids. Diffusion of solutes across bio+membranes and its application in the mechanism of respiratory Dxchange. WSalting "nX and WSalting outX of proteins. Osmotic beha5iour of cells and osmo+regulation and its application in the e5olution of excretory systems of organisms. Significance of 5isulity in biological systems+mechanism of muscle contraction; detection of in trastrand disulfide bonds in proteins; polymeri<ation of DA- and nature of blood flo7 tarongu different 5essels. Dffect of temperature solute concentration 6amino acids8 in surface tension. 2iological significance of surface tension; stability of -l5eoli in lungs; interfacial tension in li5ing cells 6Danielle and Da5son model8. "n metabolism studiesG %adioimmuno and assay 6cabeling of antigens8 "mmune radiometry. 6#/ ours8 UNIT-II 9HARMOCOFINETICS- Plasma concentration time cur5e; drug dissolution rate; phyiso+ chemical factors effecting bioa5ailability. Pharmocokinetics applied to one component open model. Calculation of elimination rate constant and metabolism constant apparent 5olume of drug distribution and kinetics of drug clearance. Protein binding of drugs; 2ioa5ailability and bio

eFui5alence. @actors affecting bioa5ailability route of drug administration and kinetics of protein binding. C/!0+ca* )+ * .'3 Jhat is lifeQ "ts chemical definition in the perspecti5e of modern scientific progress. Or+.+& $ *+$!3 spontaneous generation of life and its failureG abiotic origin of life3 >rey+ Miller!s experiment; Oparin+ aldane concept of origin of life; panaspermic origin of life and genetic code 6 life material has come from extra+ terrestrial source through meteorites. Jhat is the first important polymer in the e5olution of lifeQ %A- based origin of life. Aa%!r H the ma=or constituent of life; its physical and chemical nature that makes it 5ersatile as a sol5ent. "s life possible 7ithout 7aterQ (14 HOURS) %eferences #. Thermodynamics for chemists by S. :lasstone; -ffiliated Dast+7est press; Ae7 Delhi; 6#I/08. '. Chemical Thrmodynamics by ".M. Mlot<; J.-. 2en<amin "nc. Ae7 Lork; -msterdam; 6#I/,8. &. 2asic Physical Chemistry by J.K. Moore; Prentice all of "ndia P5t. Ltd.; Ae7 Delhi; 6#I)/8. OC8.42 S $% C r!- B+ +& r.a&+c C/!0+#%r' >A"T H" B+ c/!0+#%r' $ Ca*c+60- 2inding; transport and accumulation of Ca'*; calcium and muscle contraction; calcium in blood cloting mechanisms. B+ c/!0+#%r' $ C )a*%- 9itamin 2#' and 2#' coen<ymes; Coen<yme -; en<yme co+factor; A-D; @MA and @-D. B+ !&!r.!%+c#- Dnergy in biology; energy transfer; the energy of -TP; Minetic stability of -TP; standard free energy change entropy. igh energy compounds; mitochondrial flo7 of electrons from A-D to O'. B+ +& r.a&+c C/!0+#%r' $ 9/ #"/ r 6#- Phosphates; oxidati5e phosphorylation+substrate le5el phosphorylation; respiratory chair phosphorylation; mechanism of oxidati5e phosphorylation. Tra&#" r% a&d S% ra.! $ Ir &- @erretin; transferrin; phos5itin and gastroferrin. Ir & Tra&#" r% +& M+cr )!#- Siderophores; in vivo microbial transport of iron. 314 HOURS5 >A"T H"" D+ <'.!& 0!%a* c 0"*!<!# +& )+ * .+ca* #'#%!0- %eactions of molecular oxygen; acti5ation of dioxygen molecule in transition metal complexes. O<'.!& Carr'+&. 9r %!+&#- "ntroduction to porphyrin system; substituent effects on porphyrin rings; hemoglobin and myoglobin; model compounds for oxygen carriers 6cobalt; iridium; iron and nickel8. emerythrin and hemocyanin. E*!c%r & Tra&#" r% 9r %!+&#- "ron+sulphur proteins 6rubredoxins and ferredoxins8 and cytochromes including cytochrome P,0(. Ir & a&d C ""!r C &%a+&+&. r!d < !&@'0!#- Catalase and peroxidase. Superoxide dismutase. E+&c c &%a+&+&. !&@'0!#- -lcohol dehydrogenase; carboxypeptidase -. M *')d!&60 c &%a+&+&. !&@'0!#- -spects of molybdenum chemistry; xanthine oxidase; aldehyde oxidase; sulphite oxidase; nitrogenase and nitrate reductase.

314 HOURS5 R!$!r!&c!##. '. &. ,. 0. /. 2iochemistry H -.L. Lehninger 2ioinorganic Chemistry + %.J. ay The "norganic Chemistry of 2iological Processes H 'nd edition; M.A. ughes 2ioinorganic Chemistry HM. Satake and L. Mido. 2ioinorganic Chemistry H :.%. Chat7al and -=aykumar 2hagi. 2iological aspects of "norganic Chemistry H -.J. -ddison; J.%. Cullen; D. Dolphin and 2.%. Kames. 1. Principles of drug action3 The basis of pharmacology; 'nd edition H -. :oldstein; L. -rono7 and S. M. Malman. ). -d5anced "norganic Chemistry+"" H :urdeep %a=. I. Organometallic Chemistry H %.C. Mehrothra and -. Singh. #(. @undamental Transition metal Organometallic Chemistry H Charles M. Lukehart. ##. Modern -spects of "norganic Chemistry HDmeleus and Sharpe. #'. "norganic Chemistry H Purcell and Mot<. #&. "norganic chemistry+ K.D. uheey. #,. Organometallic chemistry by Aayori. Cr ## B rd!r "a"!r OC 8.?1 C/!0+#%r' $ )+ 0 *!c6*!# ?82 / 6r#B Car) /'dra%!#3 "ntroduction; classification; carbohydrate as energy source; structure of polysaccharides 6chitin; cellulose; starch; glycogen; dextrin8. "mportance of cell 7all polysaccharides; "ndustrial application of cellulose. 9r %!+&#3 Classification; methods of isolation and purification; denaturation and renaturation. 2iological and industrial importance of silk; casein; gelatin; seed protein; single cell protein. E&@'0!#3 Classification and biological significance. The mechanistic role of the follo7ing co+ en<ymes in the li5ing systems3+ i. Thiamine pyrophosphate 6TPP8 in oxidati5e and non+oxidati5e decarboxylation of +keto acids and formation of ketolsG ii. Pyridoxal phosphate3+ transamination; decarboxylation; dealdoli<ation and elimination reactions of amino acidsG iii. Lipoic acid in the transfer of acyl group and oxidation reactionsG i5. Co+en<yme -3 generation and transfer of acyl groupsG 5. biotin H in the addition of carboxyl groups to saturated carbon atoms and in transcarboxylation reactionsG tetrahydrofolic acid H in one carbon transfer reactions at all oxidation le5els except that of CO'G Aicotenamide and fla5in coen<ymes H in biological oxidation+reduction reactions. N6c*!+c ac+d#3 classification and biological importance; L+.&+&3 Different process of isolation; structure; importance of delignification in paper industry; biodegradation of lignins. A&%+)+ %+c#3 "ntroduction and biological importance. R!$!r!&c!# #. ". L. @inar; Organic Chemistry; DL2S Longmann; 9ol. " $ ""; #I),. '. M. -lbert; L. Lehninger; D. L. Aelson; M. M. Cox; Principles of 2iochemistry; C2E publishers; #st edition; Ae7 Delhi; #II&.

arper!s 2iochemistry; Dd. %. arper; ''nd edition; Prentice all Press; Ae7 Lork; #II(. ,. Dncyclopedia of Chemical technology H Mirck+Othmer series 0. arper!s re5ie7 of biochemistry H P. J. Martin; P. -. Mayer $ 9. J. %odf7ell; #0th edition; Maur<en -sian Ddition; California; #I)#. &. OC 8.?2 R *! $ C/!0+#%r' +& A&+0a* H!a*%/ a&d Gr (%/ UNIT I Citric acid cycle+Mrebs cycle; >ric acid formationG -ntinutritional factors present in feed components and degradation methods; -ntioxidants+ %ole of antioxidants in animals; Mechanism of actionsG Proteins+Metabolism of proteins in animals+Sources of proteins for animals; Protein deterioration due to stress; %ole of amino acids for gro7th and de5elopmentG Toxins+ Toxins found in feed ingredients; Origin of toxins; Dffects of toxins on animal producti5ity; -dsorption techniFues for irre5ersible toxin binding. Lipids+Storage of lipids in animals; Structural lipids in membranes; Oxidation of fatty acids; Metabolism of lipid in animals. 14 /r# UNIT II Dairy Chemistry+%umen metabolism; role of ruminants in global 7armingG -ntibiotics+%ole of antibiotics in animal gro7th; commonly used antibiotics; structure $ acti5ity relationship; "mplications of use of antibiotics in the food chainG Dn<ymes+%ole of en<ymes in animal gro7th $ de5elopment; en<ymes kinetics; regulatory en<ymesG Probiotics+%ole of probiotics in animal gro7th $ de5elopmentG 9itamins $ minerals+%ole of 5itamins in animals; "mportance trace minerals $ their role in animal nutrition 14 /r# R!$!r!&c!# #. Dairy chemistry and animal nutrition; 9.M. Chho<llani '. Principles of -nimal nutrition and @eed technology Part " and ""; D.9 %eddy &. @eeds and Principles of animal nutrition; :.C.2aner=ee. ,. Source book of fla5ors; eath. Masters "" Semester OC,.# ard Core3 2iomolecules >nit+" Aucleic acids3 "ntroduction; structure and synthesis of nucleosides and nucleotides; protecting groups for hydroxy group in sugar; amino group in the base and phosphate functions. Methods of formation of internucleotide bonds3 DCC; phosphodiester approach; phosphite triester and phosphoramide methods. Solid phase synthesis of oligonucleotides. Structure of %A- and DA-; Crick+Jatson model; role of nucleic acids in the biosynthesis of proteins. :enetic code; replication of DA-; (14 HOURS) U&+% II B+ " *'0!r#3 2iological importance of cellulose; starch; glycogen; dextran; hemicellulose; pectin; agar+agar. Photosynthesis and biosynthesis of other sugars. "ndustrial importance of cellulose.

9r %!+&#3 "solation; purification and classification; primary; secondary and tertiary structure; denaturation and renaturation; biological and industrial importance of silk; casein; gelatin; seed protein; single cell protein. L+.&+&3 Different process of isolation; structure; importance of delignification in paper industry; biodegradation of lignins. (14 HOURS) U&+% III E&@'0!#3 "ntroduction; nomenclature; classification 7ith examples and their functions. The mechanistic role of the follo7ing co+en<ymes in the li5ing systems3+ i. Thiamine pyrophosphate 6TPP8 in oxidati5e and non+oxidati5e decarboxylation of +keto acids and formation of ketolsG ii. Pyridoxal phosphate3+ transamination; decarboxylation; dealdoli<ation and elimination reactions of amino acidsG iii. Lipoic acid in the transfer of acyl group and oxidation reactionsG i5. Co+en<yme -3 generation and transfer of acyl groupsG 5. biotin H in the addition of carboxyl groups to saturated carbon atoms and in transcarboxylation reactionsG tetrahydrofolic acid H in one carbon transfer reactions at all oxidation le5els except that of CO 'G Aicotenamide and fla5in coen<ymes H in biological oxidation+reduction reactions. 2iogenesis of fatty acids; terpenoids 6mono and sesFuiterpenoids8; steroids; aminoacids; alkaloids. (14 HOURS) %eferences3 #. ". L. @inar; Organic Chemistry; DL2S Longmann; 9ol. " $ ""; #I),. '. M. -lbert; L. Lehninger; D. L. Aelson; M. M. Cox; Principles of 2iochemistry; C2E publishers; #st edition; Ae7 Delhi; #II&. &. arper!s 2iochemistry; Dd. %. arper; ''nd edition; Prentice all Press; Ae7 Lork; #II(. ,. Dncyclopedia of Chemical technology H Mirck+Othmer series 0. arper!s re5ie7 of biochemistry H P. J. Martin; P. -. Mayer $ 9. J. %odf7ell; #0th edition; Maur<en -sian Ddition; California; #I)#. OC:.2 Hard C r!- M!d+c+&a* C/!0+#%r' 1II U&+% I A&%+&! "*a#%+c A.!&%#3 "ntroduction; cancer chemotherapy; role of alkylating agents and antimetabolites in treatment of cancer. Mention of carcinolytic antibiotics and mitotic inhibitors. Synthesis of mechlorethamine; cyclophosphamide; melphalan; mustards and mercaptopurine. %ecent de5elopment in cancer chemothery H podophyllotoxin and its deri5ati5es; taxol. Card+ 2a#c6*ar dr6.#3 "ntroduction; cardio5ascular diseases; drug inhibitors of peripheral symphatetic function; central inter5ention of cardio5ascular output direct acting arteriolar dilators; synthesis of dithia<em; 5erapamil; methyldopa; atenolol; oxprenolol; antihypertensi5e drugs; lipid lo7ering agents 6ator5astatin; statin deri5ati5es8. L ca* a&%++&$!c%+2! dr6.#3 "ntroduction and general mode of action; structure of sulphonamides; fora<alidione; nalidixic acid; ciprofloxacin; norfloxicin; dapsone; aminosalicylic acid; isonia<id; ethionamide; ethambutal; flucona<ole; griseoful5in; chloroFuine and primoFuine. (14 HOURS) U&+% II

9#'c/ ac%+2! dr6.#3 "ntroduction; neurotransmitters; CAS depressants; general anesthetics; mode of action of hypnotics; sedati5es; anti+anxiety drugs; ben<odia<apines; buspirone; neurochemistry of mental diseases; antipsychotic drugs; the neuroleptics; antidepressants; butyrophenones; serendipity and drugs de5elopment; stereochemical aspects of psychotropic drugs; structure of ben<odia<epine drugs 6dia<epam; oxa<epam; chlora<epam8; %ecent de5elopment in CAS drugs +.theroxetine; carbano<apine; sertalins; cetalopram. (14 HOURS) R!$!r!&c!#G #. "ntroduction to medicinal chemistry; - :ringuage; Jiley+9C . '. Jilson and :is5oldTs Text 2ook of organic medicinal and pharmaceutical chemistry; Dd %obert @. Dorge. &. -n introduction to drug design; S.S. Pandey and K.%. Dimmock; Ae7 -ge "nternational. ,. 2urgerTs medicinal chemistry and drug disco5ery; 9ol+# 6Chapter+I and Ch+#,8; Dd. M.D. Jolff; Kohn Jiley. 0. :oodman and :ilmanTs pharmacological basis of therapeutics; Mc:ra7+ ill. /. The organic chemistry of drug design and drug action; %. 2. Sil5erman; -cademic Press. 1. Strategies for organic drug synthesis and design; D. Lednicer; Kohn Jiley. ). Medicinal Chemistry; - Mar; Jiley; '(((. I. Synthetic drugs; :. %. Chat7al; imalaya; Ae7 Delhi; #II0. #(. Comprehensi5e organic chemistry; 9ol. 0 6-ntibiotics8; D. .%. 2arton; J. D. Ollis; Pergamon Press; AL; #I1I. ##. "nstant Aotes Medicinal Chemistry; P :raham; 9i5a; Ae7 Delhi; '(('. OC:.8 Hard C r!- D'!# B 9 *'0!r# U&+% I D'!#3 "ntroduction; modern theories of colour and chemical constitution. - general study of the follo7ing3 Direct a<o dyes 6congored; rosanthrene O; procion dyes8; acid a<o dyes 6ponceau'%; Aaphthol blue black /28; basic a<o dyes 6chrysoidin :; bismark bro7n8; de5eloped dyes; mordent dyes; 5at dyes; disperse dyes; fibre reacti5e dyes; sulphur dyes and sol5ent dyes. @luoroscent brightening agents 6tinopal 2.98; cyanine dyes 6classification; application in photography; Fuinoline blue and sensitol8; chemistry of colour de5eloper; and instant colour processes. Synthesis and applications of malachite green; rhodamine+2; phenolphthalein and methyl orange. Triphenylmethane dyes3 crystal 5iolet; pararosaniline; aurin; chrome5iolet. -pplication of dyes3 i. photography; ii. D9D; CD and LCD; iii. 2iological studies and i5. Dlectronics. (14 HOURS) I&#!c%+c+d!#3 "ntroduction; classification; mode of action and synthesis of chlorinated insecticides 6DDT; chlordane; heptachlor and hexachlorocyclohexane8; Aaturally occurring insecticides+ pyrethroids+natural pyrethrins+isolation and structures; synthetic pyrethroids; allethrin; cypermethrin; phen5alerate. Organophosphorous insecticides3 Malathion; parathion; DD9P; dia<enon. Carbamate insecticides3 Se5in; carbofluron; aldicab; beygon. "nsect Pheromones3 "ntroduction; classification; use in insect pest control. Synthesis of disparlure; faranol; grandisol; bre5icomin and bomykol.

F6&.+c+d!#3 "ntroduction; "norganic $ organic fungicides; Systemic fungicides+types $ examples. H!r)+c+d!#- "ntroduction; study of sulfonyl ureas; heterocyclic sulfonamides; heterocyclic amines; dihydropyrano?';&+bBpyridylimida<olinones;pyrrolopyridylimida<olinones;#;';,+tria<ine+ &;0+diones; hydroxyoxa<olidinones $ hydroxypyrrolidinones; pyridine herbicides $ #;&;,+ oxadia<oles. Mechanism of action and toxicities of insecticides; fungicides and herbicides. ?#/ hrsB R!$!r!&c!# #. - Text 2ook of @ertili<ers; %an=an Mumar 2asak. '. -gronomy + Theory $ Digest; 2idhan Chandra; Mrishi 9ish7a5idyalaya; Mohanpur. &. @undamentals of -gronomy; S.S.Cheema; M.Dhali7al; T.S. Shota; Pun=ab -gricultural >ni5ersity. ,. Principles and Practices of -gronomy; Shri.S.S.Singh; -llahabad -gricultural "nstitute. 0. Principles of -gronomy; T.Lellamanda %eddy; -gricultural %esearch Station; -nantapur. /. @ertili<ers; Organic Manures $ 2iofertili<ersH- Product 4uality :uide for Ma=or $ Micronutrients; LS Tandon; @ertili<er De5elopment and Consultation Organisation; Ae7 Delhi. 1. andbook on @ertili<er Technology; 2ham S7aminathan $ Manish :os7ami; The @ertili<er -ssociation of "ndia; Ae7 Delhi. ). Outlines of Chemical Technology; Charles D. Dryden; -ffiliated Dast+Jest Press; Ae7 Delhi. I. Synthetic Organic Chemistry; :. %. Chat7al; imalaya Publishing ouse. #(. Synthesis and Chemistry of -grochemicals; 9ol " $ ""; -CS; Jahington. ##. Chemistry of Pesticides; M 2uchel. #'. -d5ances in Pesticide @ormulation Technology; -CS. #&. Chemicals for Crop Protection and Pest Managements; M 2 :reen; :.S. artley Jest; Pergamon. #0. Chemistry of "nsecticides and @ungicides; Sree %amulu; Oxford $ "2 ; #I)0. OC:.: S $% C r!- 9 *'0!r c/!0+#%r' 9 *'0!r# "mportance of polymers. 2asic concepts3 Monomers; repeat units; degree of polymeri<ation; linear; branched and net7ork polymers. Classification and nomenclature of polymers. Properties of polymers 6brief explanation of molecular 7eight; glass transition temperature + Tg ; solubility and 5isco+elasticity8. Methods of polymeri<ation+addition and condensation polymeri<ation; ionic and free+radical polymeri<ation processes; polymeri<ation 7ith complex catalysts 6Eiegler+Aatta catalysis8; co+ polymeri<ation and their mechanisms. TechniFues of polymeri<ation + bulk; emulsion etc.; Stereospecific Polymers + Preparation and significance+ classification of polymers based on physical properties + Thermoplastics + Thermosetting plastics + @ibers and elastomers +.:eneral applications. Preparation of Polymers - Preparation of Polymers based on different types of monomers +"ndustrial applications+olefin polymers + Diene polymers+ nylons + :lyptal resins + >rea+ formaldehyde; phenol + formaldehyde and melamine resins + Dpoxy resins + "on exchange resins; polycarbonates and its applications. %ubber3 Aatural and synthetic rubbers; structure elucidation of natural rubber.

Polymer degradation reactions3 Thermal; oxidati5e and radiati5e processes. Synthesis and properties of 2una+S and butyl rubbers. Conducting Polymers3 Polyanilines 9 *'0!r C/arac%!r+@a%+ &#3 "solation and purification of polymers+@ractional precipitation; partial dissolution; gradient elution and :el permeation chromatography. Principles of determination of molecular 7eights+Dnd group analysis; 5iscosity; light scattering; osmometry; cryoscopy; ebulliometry and ultracentrifugation method. Thermal characteri<ation+ "sothermal gra5imetric analysis; Thermogra5imetry ; Differential Thermal -nalysis and Differential Scanning Calorimetry. Mechanical properties+Tensile; "mpact and @lexural strengths. @lammability and Limiting Oxygen "ndex. Characteri<ation and structural analysis of polymers + "%; AM%; DS%; S+%ay Diffraction and Scanning Dlectron Microscopic Methods. ?&' hrsB REFERENCES #. Text book of polymer Science. @.J. 2illmeyer; Kr.; Kohn Jiley. London 6#II,8. '. Polymer Science. 9. %. :o7rikar; A. 9. 9ish7anathan and K. Srreedhar; Jiley Dastern; Ae7 Delhi 6#II(8. &. @undamentals of Polymer Science and Dngineering. -. Mumar and S.M. :upta. Tata HMc:ra7 ill Ae7 Delhi 6#I1)8. ,. Polymer Characteri<ation; D. Campbell and K. %. Jhite; Chapman and all; Ae7 Lork. 0. @undamental Principles of Polymer materials; %. L. %osen; Kohn Jiley and Sons; Ae7 Lork. /. "nfrared spectroscopy by %. T. Conley; -llyn and 2acon; "nc. 1. @unctional monomers and polymers by M. Takemoto; L. "naki and P. M. Ottenbrite; Marcel dekker; "nc.; Ae7 Lork; #I)1. ). Progress in "norganic Chemistry; by Stephen K. Lippard; Kohn Jiley and Sons; "nc.;Ae7 Lork; 5ol. 20; #I1/. OC:.= Hard C r!- D+#!r%a%+ & OC,./# Soft Core3 Life style chemicals U !" ! Perfumery3 "ntroduction; Compounds used in perfumery and their classification; methods of preparation and importance of phenyl ethanol; Lara yara; "onone musk ketone; musk ambrette; musk xylene; phenyl acetic acid and its esters; ben<yl acetate; synthetic musks and =asmine. @la5ours3 "ntroduction; classification; Chemical basis for fla5our; fla5ours in diary products; fla5ours formed by heating or cooking+caramelisation $ Maillard reaction; fla5our degradation by oxidation+rancidity; molecular structure $ odour.taste; s7eetness; acidity $ sourness; saltness; bitterness; synthetic chemicals; Aatural fla5ouring materials $ classification. @la5ouring materials+-cidulants; s7eeteners; potentiators; enhancers $ sodium+restricted food fla5ourings. Organic chemicals used in fla5orings $ food colorants. Dssential oils3 Source; constituents; isolation $ uses. Cosmetics3 Detailed study of formulations and manufacturing of cream and lotions; lipstick and nail polish; shampoos; hair dyes and tooth pastes. - formulary of cosmetic preparation+ :od7in. ?#/ hrsB

UNIT II Oils; soaps and Detergents3 %efining of edible oils; manufacturing of soaps; detergents+ classification+anionic; cationic; non+ionic and amphoteric detergents; comparison of soaps and detergents; detergent builders and additi5es; liFuid soaps. Manufacturing of fatty acids and glycerol; greases from fatty acids; turkey red oil. Paints; 5arnishes and inks+constitutions; examples of preparation and applications. @ood -nalysis3 Moisture; ash; crude protein; crude fiber; fat; carbohydrate; calcium; potassium; sodium and phosphates; food adultration+common adulteration in food; contamination of food stuffs; microscopic examination of food for adulterants; pesticide analysis in food products. ?#/ hrsB R!$!r!&c!# 1. Synthetic organic chemistry; : % Chat7al; imalaya publishing house. '. - formulary of paints and other coatings; M -sh $ " -sh &. Dncyclopedia of Chemical Technology; Miik $ others. ,. Perfumary Technology;2. 2illot and @. 9. Jells 0. Lehninger principles of 2iochemistry; Da5id .L Aelson and Michael M Cox /. Dairy chemistry and animal nutrition; 9.M. Chho<llani 1. Principles of -nimal nutrition and @eed technology Part " and ""; D.9 %eddy ). @eeds and Principles of animal nutrition; :.C.2aner=ee. I. Source book of fla5ors; eath. OC :.=2 S $% c r!- Medicinal chemistry """ >nit " A&%+)+ %+c#3 "ntroduction; cell 7all biosynthesis; inhibitors; +lactum group of antibiotics + Penicillin; -mpicillin and -moxycillin; amoxicillin; chloramphenicol; cephalosporin analogs; tetracycline; streptomycin; Drythromycin analogs and Ciprofloxacin. ANTI9ROTOEOAL DRUGS 1 Metronida<ole ANTIHELMENTHICS 1 Mebenda<ole.albenda<ole ANTIVIRALS - -<othymidine6-ET8; -cyclo5ir ANTITUBERCULAR DRUGS - Dthambutol ANTIFUNGALS - :riseoful5in AU"ACO!#$3 D!$+&+%+ &C Occ6rr!&c!C I# *a%+ &C C*a##+$+ca%+ &C S%!r! c/!0+ca* S%6d+!#C S'&%/!#+#C B+ * .+ca* a&d T/!ra"!6%+c $6&c%+ &# H+#%a0+&!# -H+#%a0+&! a&%a. &+#%#C -H1 )* c7!r# - C/* r"/!&!ra0+&!C -H2 )* c7!r# Ra&+%+d+&! 0+ T Seratonin; 0+ T receptor antagonist H Metaclopramide Computational chemistry and combinatorial chemistry. (#/ O>%S)
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A-T>%-L P%OD>CTS -S LD-DS @O% ADJ D%>:S Occurrence; Structure and therapeutic uses 6Synthesis Aot Dxpected8 of -8 Drugs acting on Central Aer5ous System + i8 alkaloids 6 eroin; pethidine8 i8. Cannabinoids ?I cannabinol 6T C8 28 Aeuromuscular 2locking -gents H Curare; Decamethonium

C8 -nticancer Drugs + 9inca -lkaloids 69incristin and 5inblastine8; Taxol and Taxotere; Podophyllotoxin; Dtoposide; Teniposide. D8 Cardio5ascular Drugs+Lo5astatin; Sim5astatin; Pra5astatin; Dicoumarol; Jarfarin and Mhellin R!$!r!&c!#G #. "ntroduction to medicinal chemistry; - :ringuage; Jiley+9C . '. Jilson and :is5oldTs Text 2ook of organic medicinal and pharmaceutical chemistry; Dd %obert @. Dorge. &. -n introduction to drug design; S.S. Pandey and K.%. Dimmock; Ae7 -ge "nternational. ,. 2urgerTs medicinal chemistry and drug disco5ery; 9ol+# 6Chapter+I and Ch+#,8; Dd.M.D. Jolff; Kohn Jiley. 0. :oodman and :ilmanTs pharmacological basis of therapeutics; Mc:ra7+ ill. /. The organic chemistry of drug design and drug action; %. 2. Sil5erman; -cademic Press. 1. Strategies for organic drug synthesis and design; D. Lednicer; Kohn Jiley. ). Medicinal Chemistry; - Mar; Jiley; '(((. I. Synthetic drugs; :. %. Chat7al; imalaya; Ae7 Delhi; #II0. #(. Comprehensi5e organic chemistry; 9ol. 0 6-ntibiotics8; D. .%. 2arton; J. D. Ollis; Pergamon Press; AL; #I1I. ##. "nstant Aotes Medicinal Chemistry; P :raham; 9i5a; Ae7 Delhi; '(('. Cr ## B rd!r "a"!r OC :.41 CHEMISTRY OF SOIL B FERTILIEERS UNIT I S +* C/!0+#%r'- Dssential elements for plants; @unction of essential elements+ Aitrogen; Phosphorus; Potassium; Calcium; Magnesium; Sulphur; "ron; Einc; Molybdenum; Manganese; Copper; 2oron; Chlorine; Sodium; Cobalt; F r0# $ &6%r+!&%# 6#!d )' "*a&%#- "on Dxchange in soils-Cation exchange; Cation exchange capacity 6CDC8; -nion exchange. N+%r .!& +& S +*#@orms of Aitrogen in soils; @orms of Aitrogen absorbed by plants; Aitrogen content of soils; Minerali<ation of organic nitrogen compounds; :ains of nitrogen in soils; Losses of nitrogen from soils; 9/ #"/ r6# +& # +*#-@orms of phosphorus in soils; @orms of phosphorus absorbed by plants; :ains of phosphorus in soils; Losses of phosphorus from soils; %eactions of phosphorus in soils; 9 %a##+60 +& # +*#-@orms of potassium in soils; @orm of potassium absorbed by plants; :ains of potassium in soils; Losses of potassium from soil solution; Potassium a5ailability to plants. -nalysis of soil+moisture; p ; total nitrogen; phosphorous; silica; lime; magnesia; manganese; sulphur; alkali salts and micronutrients. ?14 /r#5 UNIT II F!r%+*+#!r#- "ntroduction; Dssential plant Autrients; Classification of Dssential Autrients; Primary Autrients; Secondary Autrients; Micronutrients; Macronutrients; C*a##+$+ca%+ & $ F!r%+*+@!r#Straight @ertili<ers; Compound.Complex @ertili<ers; @ertili<er Mixtures; F!!d S% c7; Ra( 0a%!r+a*#- Aitrogenous @ertili<ers; Phosphatic @ertili<ers; Potassic @ertili<ers; Ma&6$ac%6r! a&d .!&!ra* "r "!r%+!# $ F!r%+*+@!r "r d6c%#- "ntermediates- -mmonia; Aitric -cid; Sulphuric -cid; Phosphoric -cid; Aitrogenous @ertili<ers+ -mmonium Sulphate; -mmonium Aitrate; Calcium -mmonium Aitrate; Calcium Aitrate; -mmonium Chloride; >rea; Phosphatic

@ertili<ers% :round %ock Phosphate; Single Superphosphate; Triple Superphosphate; Potassic @ertili<ers- Potassium Chloride 6Muriate of Potash8; Potassium Sulphate 6Sulphate of Potash8; Potassium Aitrate; Complex @ertili<ers - -mmonium Phosphate Sulphate; -mmonium Phosphates; Mono -mmonium Phosphate 6M-P8; Di+-mmonium Phosphate 6D-P8; Aitrophosphates; >rea -mmonium Phosphates; APM Complex @ertili<ers; @ertili<er mixtures+ Physical Mixtures; :ranulated Mixtures. ?14 /r#5 R!$!r!&c!# #. - Text 2ook of @ertili<ers; %an=an Mumar 2asak. '. -gronomy + Theory $ Digest; 2idhan Chandra; Mrishi 9ish7a5idyalaya; Mohanpur. &. @undamentals of -gronomy; S.S.Cheema; M.Dhali7al; T.S. Shota; Pun=ab -gricultural >ni5ersity. ,. Principles and Practices of -gronomy; Shri.S.S.Singh; -llahabad -gricultural "nstitute. 0. Principles of -gronomy; T.Lellamanda %eddy; -gricultural %esearch Station; -nantapur. /. @ertili<ers; Organic Manures $ 2iofertili<ersH- Product 4uality :uide for Ma=or $ Micronutrients; LS Tandon; @ertili<er De5elopment and Consultation Organisation; Ae7 Delhi. 1. andbook on @ertili<er Technology; 2ham S7aminathan $ Manish :os7ami; The @ertili<er -ssociation of "ndia; Ae7 Delhi. ). Outlines of Chemical Technology; Charles D. Dryden; -ffiliated Dast+Jest Press; Ae7 Delhi. I. Synthetic Organic Chemistry; :. %. Chat7al; imalaya Publishing ouse. OC:.42 A""*+ca%+ &# $ #'&%/!%+c "r d6c%#3 D'!#3 Colour and constitution; classification; method dyeing and their industrial importance. Dr6.#3 2asic concepts; classification; structures of 7ell kno7n drugs and their medicinal properties. 9 *'0!r#3 "ntroduction; biodegradable and non+biodegradable polymers and their industrial importance; plastics 6uses and effects on en5iornment8; natural and synthetic rubbers; polyamides and poly esters like nylon; decron; terelyne.Thermoplastics+ poly carbonates; poly acrylates in lens applications; polyurethanes and conducting polymers. S a"# a&d d!%!r.!&%#3 Production and their cleansing action. L+>6+d cr'#%a*# and their applications. S6r$ac%a&%#3 C #0!%+c#3 Detailed study of formulations and manufacturing of cream and lotions; lipstick and nail polish; shampoos; hair dyes and tooth pastes. F*a2 6r#- Aatural fla5ouring materials $ classification S(!!%&!r#3 Aatural and synthetic s7eetners. I&#!c%+c+d!#3 "ntroduction; classification; applications and their effect on en5ironment. 9/!r 0 &!#3 "ntroduction; Sources; biological importance. E<"* #+2!#3 "ntroduction; %DS; :un po7der. 6&' HOURS8 R!$!r!&c!# #. ". L. @inar; Organic Chemistry; DL2S Longmann; 9ol. " $ ""; #I),. ' M. -lbert; L. Lehninger; D. L. Aelson; M. M. Cox; Principles of 2iochemistry; C2E publishers; #st edition; Ae7 Delhi; #II&. & arper!s 2iochemistry; Dd. %. arper; ''nd edition; Prentice all Press; Ae7 Lork; #II(. , Dncyclopedia of Chemical technology H Mirck+Othmer series

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