BIS101/Martin Homework #1 (Due Week 2) Suggested problems: Problems suggested for the whole class these are not

t to be turned in, but are for practice/study aid. The following problems are on Mendelian genetics: 9th edition: Ch. 2: 22, 28, 30; Ch. 3: 26 10th edition: Ch. 2: 36, 42, 44; Ch. 3: 37 The following problems are on pedigree analysis: 9th edition: Ch. 2: 38, 40, 42, 31 10th edition: Ch. 2: 52, 54, 56, 45 The following problems are on sex-linkage: 9th edition: Ch. 2: 48, 52 10th edition: Ch. 2: 62, 66 Homework problems: 1. In mice, a recessive mutation in gene T results in tail-less animals and a second unlinked recessive mutation in gene F results in fat animals. Indicate the genotypes of the parents of the following crosses, a-d, in the space below. Phenotype of Progeny: Phenotype of Parents Tail Tail tail-less tail-less Slim fat Slim fat (a) Tail, Slim x tail-less, fat 24 0 25 0 (b) Tail, Slim x tail-less, Slim 30 10 29 11 (c) Tail, Slim x Tail, fat 15 14 4 5 (d) Tail, fat x tail-less, Slim 8 9 9 9 a)

b)

c)

d)

2. You have discovered a gene controlling tail wagging in dogs, where wagging is dominant to non-wagging. You are trying to isolate pure-breeding strains, and so cross all of your wagging dogs to a non-wagging dog and look at the progeny. Which of the following is a potential phenotypic ratio from this cross? A. 1:1 wagging:non-wagging B. all non-wagging C. 3:1 wagging:non-wagging D. 9:7 wagging:non-wagging E. none of the above are correct

3. What is the probability that each of the following pairs of parents will produce the indicated offspring? Parents A. aaBbCC X AaBbcc B. AABBcc X AaBbCc C. aabbcC X AaBbCc Offspring AaBbCc either AABbcc or AaBBcc aabbcc Probability

4. Huntington disease is a late-onset disease caused by a single, autosomal dominant mutation. The following pedigree is for a family with a history of Huntington disease. Those individuals who are already suffering from the disease are shaded black. However, some additional individuals in generations II and III also carry the Huntington allele and will develop Huntington disease but have not yet shown symptoms. Assume that individuals marrying into the family have no history of Huntington disease (that is, they are homozygous recessive for the gene). Also assume that the diseased male in generation I is heterozygous for the disease gene. I II III a b c d e f g h i j k l m a b c d e f g

a. If individuals IIIg and IIa had a child together, what is the probability that the child would develop Huntington disease?

b. If you were told that individual IId also developed Huntington Disease, would the probability calculated in (a) change? If so, what is the new probability?

c. If you were told that individuals IId, IIIe, IIIg, IIIk, and IIIm all had Huntington disease, what would be the probability of the event described in (b)?