Domingo, Jerick G.

N3A A1

Drug analysis

Drug Name:

Brand Name:

Indications:

Side Effects:

Contraindications:

Nursing Implications: Assess mental status prior to and periodically during therapy. Monitor BP and pulse prior to and frequently during the period of dosage adjustment. Observe patient carefully when administering medication, to ensure that medication is actually taken and not hoarded. Monitor I &O ratios and daily eight. Assess patient for signs and symptoms of dehydration. Monitor for development of neuroleptic malignant syndrome

Haloperidol Route Oral

Haldol

Haldol (haloperidol) is indicated for use in the treatment of schizophrenia.

0.5-5 mgs 2 or 3 times a day. In severe cases upto 100 mgs/day can be used. Parenteral

Actions: Alters the effects of dopamine in the CNS Also has anticholinergic and alpha-adrenergic 2-5 mgs repeated blocking activity. every 4-8 hours. Diminished signs In severely disturbed and symptoms of patients upto 30 mgs psychoses may be needed. Maintenance dose: 1 to 30 mg/day in 2 to 3 divided doses. Daily doses of up to 100 mg

CNS: extrapyramidal symptom such as muscle rigidity or spasm, shuffling gait, posture leaning forward, drooling, masklike facial appearance, dysphagia, akathisia, tardive dyskinesia, headache, seizures. CV: tachycardia, arrhythmias, hypertension, orthostatic hypertension. EENT: blurred vision, glaucoma GI: dry mouth, anorexia, nausea, vomiting, constipation,

Haldol (haloperidol) is contraindicated in severe toxic central nervous system depression or comatose states from any cause and in individuals who are hypersensitive to this drug or have Parkinson's disease.

Domingo, Jerick G. N3A A1

diarrhea, weight gain. GU: urinary frequency, urine retention, impotence.

Clozapine

Clozaril

Route: PO Usual dose range is 25mg-300mg daily. Starting dose is usually 12.5mg daily.

Clozapine is indicated for use in the treatment of schizophrenia. Action Binds to dopamine receptors in the CNS. Also has anticholinergic and alpha-adrenergic blocking activity . Produces fewer extrapyramidal reactions and less tardive dyskinesia than standard antipsychotics but carries high risk of hematologic abnormalities.

CNS: NEUROLEPTIC MALIGNANT SYNDROME, SEIZURES, dizziness, sedation. EENT: visual disturbances. CV: MYOCARDITIS, hypotension, tachycardia, ECG changes, hypertension. GI: constipation, abdominal discomfort, dry mouth, increased salivation, nausea, vomiting, weight gain. Derm: rash, sweating

CLOZARIL (clozapine) is contraindicated in patients with a previous hypersensitivity to clozapine or any other component of this drug, in patients with myeloproliferative disorders, uncontrolled epilepsy, paralytic ileus, or a history of As with more typical antipsychotic drugs, CLOZARIL is contraindicated in severe central nervous system depression or comatose.

Monitor patients mental status (orientation, mood, behavior) before and periodically during therapy. Monitor blood pressure (sitting, standing, lying) and pulse rate before and frequently during initial dose titration. Observe patient carefully when administering medication to ensure that medication is actually taken and not hoarded or

Domingo, Jerick G. N3A A1

cheeked. Clozapine lowers the seizure threshold. Institute seizure precautions for patients with history of seizure disorder. Monitor for development of neuroleptic malignant syndrome (fever, respiratory distress, tachycardia, seizures). Notify health care professional immediately if these symptoms occur.

STN: Domingo Jerick G. N3A A1