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More information: http://www.guidechem.com/cas-443/443-48-1.

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More information: http://www.guidechem.com/cas-443/443-48-1.html

Metronidazole Information
Metronidazole (CAS NO.443-48-1) is a prodrug. It is converted in anaerobic organisms by the redox enzyme pyruvate-ferredoxin oxidoreductase. The nitro group of metronidazole is chemically reduced by ferredoxin and the products are responsible for disrupting the DNA helical structure, thus inhibiting nucleic acid synthesis. Metronidazole is selectively taken up by anaerobic bacteria and sensitive protozoal organisms because of the ability of these organisms to reduce metronidazole to its active form intracellularly.

Metronidazole is an antibiotic especially effective against anaerobic infections (infections that grow without the presence of oxygen.) With the CAS NO. 443-48-1, it also can be called Acromona; Anagiardil; Arilin; Atrivyl. It should be stored below 25C and protect from light. Metronidazole suppositories should be stored below 20C.A nitroimidazole used to treat amebiasis ; vaginitis ; trichomonas infections ;giardiasis ; anaerobic bacteria; and treponema infections . It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens this substance may reasonably be anticipated to be a carcinogen.

Uses of Metronidazole:

Metronidazole is used also as a gel preparation in the treatment of the dermatological conditions such as rosacea (Rozex and MetroGel by Galderma) and fungating tumours (Anabact, Cambridge Healthcare Supplies).

Physical properties about Metronidazole:

Name:Metronidazole EINECS:207-136-1 Molecular Formula:C6H9N3O3

More information: http://www.guidechem.com/cas-443/443-48-1.html

CAS Registry Number:443-48-1 InChI:InChI=1/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3 HS Code:29332990 Appearance:White to slightly yellow crystalline powder. Molecular Weight:171.15 Density:1.45 g/cm3 Boiling Point:405.4 C at 760 mmHg Melting Point:159-163 Flash Point:199 C Storage Temperature:2-8C Refractive index:1.612 Solubility:<0.1 g/100 mL at 20 C in water Stability:Stable. Incompatible with strong oxidizing agents. Usage:Microbiocide When you are using Metronidazole, please be cautious about it as the following: 1. Wear suitable protective clothing and gloves; 2. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible); 3. Avoid exposure - obtain special instruction before use.

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