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This document summarizes surface molecules found on immune cells and their locations, ligands, and actions. Key molecules include CD3, CD4, and CD8 which are found on T cells and interact with MHC complexes and signal transduction. CD28 and B7 interact to provide costimulation of T cells. Molecules like CCR7, CCL17 direct cell trafficking, while selectins and integrins like LFA-1 mediate adhesion between immune cells and endothelium. FasL induces apoptosis through FasR interactions.
This document summarizes surface molecules found on immune cells and their locations, ligands, and actions. Key molecules include CD3, CD4, and CD8 which are found on T cells and interact with MHC complexes and signal transduction. CD28 and B7 interact to provide costimulation of T cells. Molecules like CCR7, CCL17 direct cell trafficking, while selectins and integrins like LFA-1 mediate adhesion between immune cells and endothelium. FasL induces apoptosis through FasR interactions.
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This document summarizes surface molecules found on immune cells and their locations, ligands, and actions. Key molecules include CD3, CD4, and CD8 which are found on T cells and interact with MHC complexes and signal transduction. CD28 and B7 interact to provide costimulation of T cells. Molecules like CCR7, CCL17 direct cell trafficking, while selectins and integrins like LFA-1 mediate adhesion between immune cells and endothelium. FasL induces apoptosis through FasR interactions.
Copyright:
Attribution Non-Commercial (BY-NC)
Formati disponibili
Scarica in formato DOC, PDF, TXT o leggi online su Scribd
CD3 All T cells Signal transduction by TCR CD4 TH Cells MHC-II Adhesion w/ APCs and signal transduction CD8 CTL MHC-I Adhesion w/ APC, CTL target cells, signal transduction CD28 Naïve T B7 Signal transduction (costimulation) lymphocyte CD40 B cells, APC CD40L Activate MØ via ↑ gene expression “Emeril effect” CD40L T cells CD40 Activate MØ via ↑ gene expression B7 APC CD28, CTLA-4 2nd signal for T cell (+ or -) Expression ↑↑ by IL-2 CTLA-4 T cells B7 ↓ T cell activation (negative Higher affinity regulation) than CD28 CR2 B cells Complement Can provide 2nd signal to activate B bound to Ag cells w/o T cell CCR7 Dendritic cells Drives emigration to lymph node CCR10 Skin-homing T cell CCL17 Vascular endothelium CCL25 Small Intestine CCL27 Skin keratinocytes CCL28 Large Intestine MAdCAM-1 Gut epithelium Bind w/ L-selectin and integrin LFA-1 T cell, MØ, PMN, ICAM on Firm Adhesion w/ APC, endothelium High affinity state dendritic endothelium ↑ T cell response VLA-4 T cell VCAM Firm Adhesion w/ endothelium VLA-5 Monocytes, MØ Fibronectin L-Selectin Naïve T cells L-Selectin Slowing of T cells in High Lost on activated Ligand Endothelial Venules in lymph nodes T cells Trafficking to lymphoid organs E-Selectin Peripheral E-Selectin Slowing of rolling (weak adhesion endothelium Ligand (Sialyl- Lewisx) P-Selectin Peripheral P-Selectin Slowing of rolling (weak adhesion) endothelium and Ligand (PSGL- platelets 1) FasL CTL FasR Activation of death pathway