DMS - A MULTIFUNCTIONAL LAMELLAR SYSTEM FOR BARRIER IMPROVEMENT IN DRY AND VERY DRY SKIN

- short summary; y for further details p please contact birgit.gertchen@kuhs.com -

In-Cosmetics Asia, October 13, 2009

A Agenda d
The lipid p barrier intercellular lipids p Disruptive effects on the lipid barrier and their manifestations DMS - delivering to the skin what it needs DMS - efficacy studies and handling aspects Summary

Ending Problem Dry Skin A Never Never Ending

Dry Skin

Emulsification of SC Lipids / Barrier Disruption

Conventional Moisturizer / Occlusion

Contact with Water / Detergent

Concept for an ideal cosmetic preparation

Physiological ingredients
membrane lipids p naturally y found in the skin

Physiological structure
lamellar arrangement of water and oil phase

Target
High tolerance by all skin types Product safety combined with highest possible efficacy Targeted delivery of actives (where desired)

DMS - Derma Membrane b Structure t t Platform Technology

Structure forming base concentrate for creams & lotions Lipid composition of DMS follows the physiological
formation of the epidermal intercellular lipids

Lamellar microstructure of the concentrate

similar to the bilayer organization of the stratum corneum

Barrier strengthening effect Adjustable to numerous final formulations

Comparison C i of f Composition C ii

skin lipids
triglycerids squalen ceramides cholesterol phospholipids

DMS cream
caprylic/capric triglycerids squalane ceramide 3 phytosterols p y phospholipids (plant.) (plant ) (plant.) (yeast) (plant.) (p ) (plant.)

Structures Compared

DMS Cream
(Freeze fracture EM)

O/W cream
(1000 x LM)

Stratum Corneum
(Freeze fracture EM)

Avoiding A idi potentially t ti ll critical excipients p

emulsifiers preservatives mineral oils fragrance dimethicones dyes

Claim Substantiation
Prolonged Moisturization Clinical effect in AD (Physiogel AI ATOPA) Barrier enhancement
Protection against hydro hydro-& lipophilic irritants Comparative barrier integrity study DMS vs. conventional emulsifier

DMS Handling Aspects

Typical use level

Creams: 20-30% Lotions: i 10-15% %

DMS / lipid ratio > 10% DMS 1:1 app. > 20% DMS 1:1 1:1,5 app. No further surfactants / emulsifiers in the final formula Electrolytes may have an impact on the DMS stability, stability max. 5% recommended

Summary: y Using g DMS,

Formulators
Respect the nature and requirements of the skin Pay the attention necessary to a safe and efficient formulation base Dispose of a robust and versatile platform technology adaptable to numerous application fields Rely R l on safety f t and d efficacy ffi proven clinically Have a tool for the truly innovative treatment of dry, sensitive and even damaged skin

Consumers
Of all ages will no longer suffer from dry skin Will be pleased with the smooth and non-sticky non sticky texture of the formulations Will appreciate the strict avoidance of all ingredients with potentially irritating effects Will never give up a DMSbased product again!