Arthritis and Other Autoimmune Diseases

Envision the internal workings of your body. See your heart pumping blood, pushing it through the more than 10,000 miles of blood vessels each of us possess. See your lungs filling up with oxygen and exchanging it with the carbon dioxide coming out of the "used" blood, and then pushing out the stale air. See your hundreds of muscles working together to produce the finest and most powerful of movements. See the digestion of foods into the building blocks and energy fuel for your marvelous body. See your body producing substances to repair and protect itself from foreign invaders. When everything is perfectly timed, all parts working in unison toward the same goal, you have a description of health. However, with autoimmune diseases, something goes wrong, causing the body to work overtime, and in the wrong direction or in two directions at once. Autoimmune disorders exist when a person's body produces abnormal cells or anti-nuclear antibodies (ANA) which, instead of attacking the legitimate infectious, viral invaders, and mutated cells of the body, turn and attack aspects of the healthy body itself. ANA cells, once they have become wrongly educated, do not recognize healthy cells, tissues and organs as such, and will attack them as though they were invaders. A person's immune system becomes confused, poorly defending against outside invading agents, while attacking healthy tissues and organs. This is a problem with the memory T-cells of the immune system. So it stands to reason that any remedy that does not address the defect in the memory T-cells, but rather only addresses the symptoms caused by the problem, will not work. These symtom remedies may make you feel somewhat better temporarily, but they will not bring you out of the condition. There are many people living with autoimmune diseases and the numbers are increasing quickly. Autoimmune diseases take many forms:

Multiple Sclerosis is present when the immune system attacks the nerve tissues of the central nervous system, destroying the myelin sheath. This usually causes severe disability - blindness, paralysis, and early death. Rheumatoid Arthritis exists when joint linings are directly affected, causing pain, swelling and stiffness and sometimes severe malformation of the joints. Inflammatory Bowel Disease (such as Crohn's and Ulcerative Colitis) results when the immune system attacks the intestinal areas, causing pain, diarrhea, nausea, and abdominal cramps. Systemic Lupus Erythematosus usually exhibits itself with extreme fatigue, rashes and joint pain. A rash on the cheeks across the bridge of the nose is very common. Major organs may also be affected, causing severe problems for the kidneys, brain, or lungs. Psoriasis (and some other skin disorders) affect the skin and sometimes the eyes, nails, and joints. Scleroderma exists when the skin and blood vessels begin to thicken. Raynaud's Syndrome (severe cold in fingers and toes) is often also present. Symptoms may include sensitivity of fingers and toes to the cold, skin color changes, pain, and sometimes ulcers of the fingertips or toes. Fibromyalgia symptoms includes severe fatigue, overall body aches and pains, sleep disorders, stiffness

of body joints, headaches, memory and concentration problems, fluid retention, intestinal problems, and other mixed symptoms. There are usually several "tender points" scattered throughout the body which, when pressure is applied, can cause a person very severe pain, even causing them to double over. Sjogren's Syndrome is a condition affecting the body's fluid-producing glands. These glands reduce their fluid output and eventually run dry, causing a person to suffer from dry eyes, dry mouth, and dry skin. Sometimes sore and aching muscles, extreme fatigue, and other autoimmune and connective tissue diseases will develop. Diabetes - Some diabetes is caused by an autoimmune attack on the islet cells of the pancreas reducing the quantity of insulin released into the blood. ALS (Lou Gehrig's Disease) and AIDS are both massive autoimmune diseases that eventually destroy the entire body. What is common with all these diseases is that they have the same cause. There are other factors that modify the effects of the disease, but the cause is the same. In all forms of treatment expediency is a must. If you have an autoimmune disease, you don't want to wait even one more day before you do something about it. The key is to do the right thing.

The Autoimmune Process

The general health of a person and any essential nutrient deficiency is going to play a role in all of this process. All cells of the immune system are derived from stem cells in bone marrow. The bone marrow is the origin of red blood cells, white cells (including lymphocytes and macrophages), and platelets. In the thymus gland lymphoid cells undergo a process of maturation and education prior to release into the circulation. This process allows the lymphocyte T-cells to develop the important attribute known as self-tolerance. That is, the T-cells are learning to recognize and tolerate "self," meaning any cells that are a normal part of your body! The thymus gland is a place where a potential problem can develop with memory T-cells. Injuries, infections, and wear can affect the condition of our bodies. An injury could be a fall, an automobile crash, or a sports injury. An infection can be rheumatic fever or any virus or bacteria, or it could come from an internal parasite. Wear can come from being overweight, overwork from sports such as tennis, basketball, or golf, or it can be job related, such as excessive use of keyboards or jackhammers. The twisting of a knee one time can cause arthritis to develop many years later, even after the injury is completely healed! The injury, infection, or wear can cause some small part of the body to dislodge, perhaps the myelin surrounding the nerve or perhaps some cartiledge from a joint. And this is where the process starts. The white blood cells known as macrophages play a function in immunity by surrounding, ingesting, and destroying invading bacteria and other foreign organisms in a process called phagocytosis ("cell eating"), which is part of the inflammatory reaction. These macrophages consume the broken off particles and report their activities to the memory T-cells! The dormant memory T-cells activate and develop an aggressive cleanup program. If the memory T-cells do not distinguish between healthy and damaged tissue, as the increased T-cell activity stimulates more macrophage activity which in turn stimulates more memory T-cell activity, the process of self destruction has begun. It can take many years before any noticeable effects are felt. The initiating factor, the injury, infection, or wear may have disappeared long ago. There may be no evidence of a degenerative disease because not enough material has been destroyed by this process to show any symptoms. Arthritis sets in, almost in every case some ten years after an injury or surgery. Because it gradually happens over a long period, people tend to ignore it until it becomes unbearable.

But once you become aware of what's happening, waiting is the worst thing you can do! Why should you let yourself deteriorate more before you decide to do something about it? That would be like letting your house burn down some more before you put out the fire. The only intelligent way is to stop it as soon as possible. You can buy a new house, but you can't buy a new body. An autoimmune disease is self-propagating. It does not depend on the initiating factor to keep it going. The initiating factor may have healed completely a long time ago, but the auto-immune process, once set in motion, keeps going. The process is exacerbated by the fact that the mechanism that is supposed to deactivate the memory T-cells when they have completed their mission fails to respond or work properly. So there are an abundance of memory T-cells directing the macrophages to search the body for more material to consume. The immune system is totally out of control, massive destruction begins, and the symptoms of pain and inflammation appear. The destruction accelerates. Symptoms become more severe. In arthritis for example, pain, inflammation, and joint deformity appear at new sites as they suffer macrophage attacks. Medications may take away the pain temporarily but they can't stop the body's process. The body is just doing what it thinks it should be doing. But even natural ways of dealing with the pain and inflammation do not stop the process, because strengthening the immune system can actually strengthen the disease. Conventional medications take their toll on the kidneys, liver, and heart, and do not stop the process. Products, natural or conventional, that treat the symptoms of an autoimmune disease effectively deceive you because the deterioration is continuing even though you don't feel it anymore. This is like cutting the wire to a warning light on the dashboard of your car, rather than fixing the problem that is activating the light in the first place. The more knowledgeable modern physicians in recent years used products called immunomodulators to correct the autoimmune problem. The only problem was the immunomodulators were not true immunomodulators. What they really were were immunostimulants or immunosuppressants. These natural or synthetic substances can produce onlyone effect each, either stimulate or suppress the immune system. A true immunomodulator would have the ability to correct the defect in the memory T-cells! If you use immunostimulants or immunosuppressants as part of your autoimmune plan you will have to use them until the day you die. If you are at the early stages they may seem to cure the disease because they take care of the symptoms. That is the deception. There are some true immunomodulators. Some are manufactured and some occur in nature. It is always better to use the natural substances. For example: colostrum and spirulina both contain natural immunomodulators.

Arthritis and Autoimmune Disorders

Do you suffer with arthritis or any other autoimmune disorder? Have you learned to "live with it?" Have you been told there is nothing you can do about it? Do you believe it? Autoimmune diseases cannot be cured with drugs. But ask yourself, "Is it possible that my body could heal itself of this disorder if my body was supplied with every nutrient it needed so that its systems could function properly?" There are a lot of scientific and biological studies that indicate the answer is yes. Don't resign yourself to failure, even though you have tried many things that have failed. There are new, natural substances that are continually being discovered (not created). Yes, it can be painful to keep trying. Having your hopes dashed again and again can be the most painful thing of all. But one thing for sure, if you quit trying, you will never succeed!

Excerpt reprinted from a memo released by Dr. Len Sands, Director of the San Diego International Immunological Center The Arthritis Process Step-By-Step with CMOT Intervention 1. Infection, trauma, or excessive wear affects some joints. (Usual infections are rheumatic fever, flu, or bacteria. Traumas include auto wrecks, falls, sports injuries, etc. Excessive joint wear comes from being overweight, or from repetitive stress such athletic exertion, use of keyboards, jackhammers, etc.) 2. #1 causes damaged or infected cartilage particles to become dislodged. This happens regardless of whether it's "osteo" or "rheumatoid" or "reactive" arthritis. 3. Macrophages of the immune system begin cleanup of dislodged cartilage particles. 4. Macrophages report their activities to dormant memory T-cells (m/T-cells). 5. Dormant m/T-cells programs activate and develop aggressive anti-cartilage cleanup programs, which do not distinguish between healthy and damaged cartilage. 6. The m/T-cells programs stimulate more macrophage activity, which in turn activates even more dormant m/T-cells. 7. Increased m/T-cell population stimulates even more macrophage activity, and the self-perpetuating cycle of cartilage destruction expands. Because m/T-cell programs don't limit macrophage activity to damaged cartilage only, destruction of healthy cartilage also occurs. It has developed into a destructive autoimmune syndrome. But, until sufficient cartilage has been destroyed, symptoms are not evident. The initiating factor (infection, trauma, or wear) may have disappeard months or even years ago, but the destructive autoimmune process remains active. It is self-perpetuating and no longer dependent upon the initiating factor. 8. The cycle is compounded by the fact that the mechanism which should deactivate certain m/T-cells (those that have completed their mission) fails to function, because the constant restimulation of the m/Tcells keeps them active. So now there is an overabundance of m/T-cells propelling macrophage cartilage destruction. The immune system is totally out of control and massive cartilage destruction begins. Early symptoms of pain and inflammation appear. 9. Cartilage destruction accelerates. The cycle reaches critical mass. Macrophages are now scouring the body to find and destroy any cartilage anywhere it can be found. Symptoms become more severe. Pain, inflammation, and joint deformity appear at new sites as they suffer macrophage attacks. 10. Symptoms of pain, stiffness, swelling, nodules, and deformation often reach intolerable and crippling levels - especially as joint cartilage disappears and bone-on-bone erosion occurs. Conventional arthritis medications take their toll on the liver, kidneys, and heart. Normal life span is often shortened by up to ten or twenty years from both the ravages of arthritis and side effects of medications used.

INTERVENTION (the sooner the better) with CMO can stop the autoimmune process at any point.
Dr. Len Sands, PhD, now deceased, was the clinic director of the San Diego Immunological Center and the author of the books Arthritis Defeated at Last - the REAL Arthritis Cure and Arthritis Beaten Today , which have been translated into five languages so far, including Chinese. After ten years working on classified government projects, Dr. Sands began his direct active participation in clinical matters in 1970, as an associate of Manhattan Fifth Avenue Clinic in New York City. Within the next four years, he opened and became the owner and director of six medical clinics, as well as acquiring Southland General Hospital in Texas. Later, he opened two medical clinics in Mexico. He became involved in medical research projects concerning autoimmune diseases, viral diseases, diabetes, and cancer.

By the mid-1980s, he was thoroughly disillusioned by the limitations of conventional medicine and spent the next ten years traveling the world researching innovative therapies involving both conventional and alternative medicines, especially seeking those which were documented by exacting clinical trials in the major European countries. He also explored many unconventional as well as documented therapies in various Asian, Middle Eastern, Latin American, and Oceanic countries. As clinical director of the San Diego Immunological Center, he encouraged his researchers and medical staff to specialize in what he calls "curing the incurable" - diseases for which convetional medicine offers no hope of remedy. Curing the Incurable was the title of a one-hour interactive weekly radio program Dr. Sands hosted in 1997. Early in his career, he produced scientific and marketing material for industrial corporations, as well as for Parke-Davis and the pharmaceutical division of the Dow Chemical Company and others. It was Dr. Sands' own bone-grinding arthritis that prompted him to relentlessly prod his research associates into finally finding a lasting cure for arthritis. The research resulted in the development of the world's first and only true immunomodulator, a naturally occurring substance that should impact the course of medical history, but probably won't since it is not a patented medicine. However, it certainly is changing the way autoimmune diseases will be addressed in the future. That discovery, CMOT (cerasomal-cis-9-cetylmyristoleate) in 1995, is proving to be of great value for numerous other incurable diseases with strong autoimmune factors, like multiple sclerosis, fibromyalgia, lupus, ALS (Lou Gehrig's Disease), emphysema, Crohn's disease, scleroderma, sarcoidosis, and myasthenia gravis, among others. It is also relieving or curing ankylosing spondylitis, psoriasis, carpal tunnel syndrome, prostate inflammation, Sjogren's syndrome, TMJ, Behcet's syndrome, macular degeneration, Reiter's syndrome, sciatica, tendonitis, and more - all of which have strong autoimmune components. CMOT is now being used to treat autoimmune diseases on every continent in the world. As its phenomenal success with these diseases uncovers more options, the research goes on. Nothing would have pleased Dr. Sands more, including the continuing research and clinical studies on even more diverse incurable diseases. Therapies using CMOT combined with the proper supportive nutritional products and proper diet for a minimum of the first 30 days have been proven to be beneficial for all autoimmune diseases like those mentioned above, plus muscular dystrophy, chronic fatigue syndrome, Alzheimer's, Parkinson's, Raynaud's, hypertension, and heart and vascular diseases, as well as ridding the body of conditions caused by environmental, dental amalgam, medicinal, chemical, metallic, and other toxins. CMOT is the world's first and only true adaptogenic autoimmune immunomodulator product. CMOT is not an immunosuppressant or an immunostimulant. CMOT is considered "adaptogenic", meaning: it is capable of altering the course of a disease in a positive direction, because of its corrective and restorative immunomodulatory properites for autoimmune diseases and inflammatory processes. Other so-called "immunomodulators" are not true immunomodulators. They function as immunosuppressants or immunostimulants. They are capable of one principle action, either temporarily suppressing or stimulating immune function, not correcting or restoring it. CMOT, on the other hand, permanently corrects the programmed autoimmune attacks controlled by the memory T-cell (m/T-cells) themselves. That is why a single 30-day CMOT therapy program of three 90 caplsule bottles (270 caplets) (3 capsules, 3 times a day) ordinarily lasts indefinitely without any need to repeat the therapy or use any additional medications of any kind thereafter. Some practitioners have theorized that, in the case of arthritis for example, CMOT merely acts upon pain receptors at the arthritic site. It that were so, their theory cannot explain why CMOT has the following effects: It It It It It benefits virtually any and all ailments associated with autoimmune diseases. lowers blood sedimentation in lupus patients. relieves certain symptoms of multiple sclerosis. reverses lung inflammation in emphsema. lowers the need for insulin in diabetics.

It It It It It

reverses prostate inflammation. corrects Crohn's disease. reverses fibromyalgia. improves the health of ALS (Lou Gehrig's Disease) patients. lowers high blood pressure, yet elevates low blood pressure.

CMOT is a general remedial immunomodulator that acts upon the memory T-cells, which control the autoimmune processes within our bodies. It is also important to understand the CMOT acts only upon memory T-cells and does not inhibit the activities of any of the several other types of T-cells that are responsible for combating infective microorganisms or invading substances. Unlike the immunosuppressants commonly used to try to temporarily control the symptoms of autoimmune diseases, CMOT does not leave the body vulnerable to attack by disease-causing agents. Neither does it inhibit the body's resistance to tumor formation, as do the dangerous new tumor necrosis factor (TNF) suppressants of some new arthritis drugs. Authentic CMOT, as reasearched and developed by the San Diego Immunological Center is the primary ingredient of Dr. Jeff's Joint Health Click here for Dr. Jeff's Joint Health Dr. Jeff's Joint HealthT which combines CMOT and MSM was developed using the combined research of Dr. Sands, Dr. Grange, Dr. Bennert, and a host of other professionals, who collectively believe this is the most effective combination of ingredients available on the market today to combat and prevent autoimmune disfunctions. It is important to follow the directions. Take 3 bottles, 90 count each, totalling 270 caplets for the first 30 days, three upon waking, one hour before eating, three one hour before lunch, and three before dinner. Dr. Jeff's Joint CreamT will help for immediate pain and dull aches. For full effectiveness follow the recommended diet, and on an ongoing basis supplement Dr. Jeff's Joint HealthT by drinking at least 1 1/2 quarts of Marine Bio Coral Calcium (scroll down the products list to "Sango Coral Calcium") treated distilled water daily and taking digestive enzymes RBC's Digestion Formula (Scroll down the list to "Digestion Formula" ) , Omega 3 Oil RBC's IQ (Scroll down the list to "I.Q."), anti-oxidants RBC's Microhydrin Plus ( Scroll down the products list to "Microhydrin Plus") and Dr. Jeff's BioPro with SBOs (soil-based organisms). After your condition is reversed, to maintain your health on a monthly basis, we recommend one bottle of Dr. Jeff's Joint HealthT and a monthly supply of the other support ingredients mentioned above. The San Diego International Immunological Center (SDC) is a research and treatment facility and does not sell or benefit from the sale of CMOT or any other product. We do, of course, dispense CMOT and the supporting nutritionals to subjects enrolled in our studies and to clinic patients who may be part of our diagnosis and treatment programs. CMOT counterfeiters seem to show up every week. Most are hit and run artists and quickly disappear. CMOT is made in 6%, 11%, 40%, 50%, 80%, and 100%. It is difficult and confusing to know if you have found the real 100% authentic CMOT source or some ineffectivbe imitation. The reliable sourse for authentic CMOT is Dr. Jeff's Joint HealthT and Dr. Jeff's Joint CreamT Use the "Products" link on the upper left of this page or the links within this article to find these products. NOTE: This document is supplied for information and educational purposes only. It is not intended to recommend or prescribe any treatment for any condition or illness. Contact a doctor or medical professional who is trained in natural nutritional supplements before adding any new protocol or when starting any health or exercise program. Dr. Len Sands. All rights reserved

It is important to recognize that CMO+ is the first product of its kind in history.
The first dietary joint supplement to guarantee results after 10 days of use. That is what makes CMO+ so very special. CMO+ is a truly important discovery and it may well revolutionize joint health worldwide, using only dietary supplements. Natural products are slow to be applauded in the world of healthcare. When this one becomes as well known as vitamin C or baby powder, we won't be able to keep up with the demand.

Click here for Arthritis Studies

The discovery of cetylmyristoleate

The effect of cetylmyristoleate on joints was discovered by U.S.National Institutes of Health chemist H. W. Diehl and an article describing its discovery was published in Journal of Pharmaceutical Sciences [83(3):296298]. Cetylmyristoleate, however, had to be injected to be effective. Like other liquid waxes it is composed of large molecules that tend on clumping together forming large impenetrable masses which resists absorption and pass through the digestive system virtually undigested.

Making the indigestible digestible

Aware of the great potential of the substance, the San Diego Clinic Immunological Center under Dr. Len Sands , invented an exclusive way to change the liquid was into a waxy solid named cerasomal-cis-9-cetylmyristoleate (CMO). As a solid, CMO has a crystalline structure that shatters in the alkaline environment of the small intestine forming a mesh of small particles that is readily absorbed and digested by the intestines. The exclusive process is responsible for CMO's greater bioavailability and efficacy.

Making the digestible even more digestible

For several years, companies have advised users to take a mixture of digestive enzymes along with the CMO to make it even more digestible. Nutritional Health Services has incorporated 2 lipase enzymes into each CMO+ capsule. To the best of our knowledge, CMO+ is the first and only CMO supplement to contain these two enzymes which are specific in amount and type for optimal digestion of the content of each CMO+ capsule. The built-in enzymes increase both the absorption and the efficacy of CMO+.

Products to look out for:

Cetylmyristate: Without the "oleate", signifying a salt of oleic acid, the compound is incapable of supporting the natural functions of joints. While these products are cheap and may retail for $3 or $4 a bottle wholesale, they are worthless as joint supplements. Vegetable sources: Beware of products that claim to be "cetylmyristoleates" from "vegetable sources". In order to

make any form of myristoleate, including cetylmyristoleate, you have to start with myristoleic acid. The biochemist's bible Baily's Industrial Oil and Fat Products 5th Edition, lists only four sources for myristoleic acid, namely beef tallow, butter fat, chicken fat, and sheep tallow. There are no vegetable sources. Any claim that cetylmyristoleate came from a vegetable source -- including coconut oil or soybean oil -- is fraudulent . Watch out for dangerous synthetics: Synthetic cetylmyristoleate is not the same as natural cetylmyristoleate. The structure of the synthetic molecules is different. Roughly half of the synthetic molecules are what is known as 'trans' molecules (as opposed to 'cis' molecules). The trans molecules are unnatural to the body and cause physical damage by disrupting cell membranes. Because CMO+ is an all-natural product, it contains absolutely no trans molecules . The word 'cis' in cerasomal-cis-9-cetylmyristoleate is your assurance that CMO+ is 100% free of the unnatural, harmful trans molecules found in all of the synthetics.

Friday, November 22, 2013

We realize that those who do not respond well to CMO+ do not write to say so. They simple request a refund. This is true of 810 % of our customers. Therefore it is important for you to understand that the grateful CMO+ users who wrote these testimonials represent the remaining 90 -92% of our customers. One way or another, we guarantee you'll be happy with our company. Good results speak for themselves. Customers who feel they did not receive beneficial results, although disappointed with our product, are happy to receive a refund. What determines who can get a refund? We believe people are honest and would not ask for money back if they benefited from our products. Therefore, all you have to do is request a refund in writing, either e-mail or snail mail. Do wait at least 30 days after finishing the capsules before requesting a refund if you need one. Beneficial results are sometimes subtle at first and may be slow to appear. However, for most, the improvement continues for months and results are usually very long lasting. All bodies repair at different rates.

Date: Sun, 17 Jun 2003 23:02:26 EDT From: Audrey Travis. Dear Marge , I've used CMO a couple of years ago, and I must say I am a true believer. I no longer have the pain in my neck or feet and the ugly knots and swollen joints are gone. I tell everyone I know that suffers from the same kind of pain about my wonderful results. Thank you! Audrey Travis (Texas) From: Wendy Thronburg <wmhs@trib.com> To: Marge Berger <info@bestcmo.com> Sent: Monday, February 05, 2003 01:46 PM Subject: Re: Sarcoidosis Hi Marge! I wasn't sure the CMO would work for Steve, but it did! He has given me permission to write you his testimonial. In October of 2000, my boyfriend Steve Wiecki (from Thermopolis, WY) was given the temporary diagnosis of Sarcoidosis. He was given anti-inflammatory drugs and pain medication, and was told to return in about 5 weeks for a check-up, and to return sooner if symptoms got worse. Well, he gradually showed a decline in his health and eventually, in December had to return. At that time, he was referred to a Pulmonologist. He met with the doctor and found out that he had to have a biopsy done. There was concern about if it was cancer, or indeed Sarcoidosis. Well, the biopsy went well and it was determined that he did have Sarcoidosis. At the time, it was affecting his lymph nodes and breathing. He had lost 20 lbs., had difficulty eating, swallowing, and his overall health was declining. He used to lift weights and was very physically fit and in a matter of months felt tired, was weak, and felt very ill. When he was in the hospital for the biopsy, I began doing more research on alternative methods to treat Sarcoidosis. The information that I had read

on steroids was troubling and I just didn't want him to have to go through that. I discovered your web-page on CMO+ and I felt like it was an answered prayer! Steve was not only struggling with his health, but having no medical insurance through where he works, he was paying for all medical expenses himself. He felt terrible, and he was discouraged and depressed regarding his circumstances. I printed the information from your web-page and discussed it with him. After awhile, we decided that it would be something worth trying. His attitude was that it couldn't hurt and that if it didn't work, he would just have to take the steroids. Well...after day 3 of taking the CMO+, he started feeling better. He could breathe again without pain! He continued for the entire 10 days and I am sooooo happy to report that he feels great! He is eating again, he can swallow, he can breathe, he has no chest pain, etc. All of his symptoms are gone! I am praying that the results are lasting, but if they aren't, we know where to go to get more! Thank you for your product...it has been a blessing! I have given your product information to several people that have arthritis and Crohn's that I know and I am encouraging them to try it. Steve is a walking testimonial and all that know him have seen the incredible results. Thank You AgainWendy Thronburg, (Worland, WY)

Date: Fri, 12 Jan 2003 14:08:28 -0800 Subject: CMO From: Mark Howell howell@harmonyexchange.com To: info@bestcmo.com Hello Marge, In September of '00 I was diagnosed with Sarcoidosis. This diagnosis was finally achieved after a year's worth of terrible symptoms & many, many tests. This mysterious disease can attack the body in so many different ways and from everything I learned during this ordeal, the medical community has only scratched the surface in understanding this illness. The current trends are to treat the disease with drugs such as Prednisone or Methatrexate and I, personally, was too worried about the side effects of those drugs to go that route. I don't want to discourage others from taking those drugs but I wanted to explore other options for myself before I made that decision. While on the internet I happened upon your site. I was very skeptical but intrigued by your information and I decided that I had nothing to lose by giving it a try. I am glad that I overcame my skepticism and ordered the product. I noticed an improvement in my symptoms within 3-4 weeks after starting the product. One of the major problems I had was a grossly enlarged spleen, 4-5 times normal size. I noticed a reduction in the size of my spleen and when I commented about this to my doctor he did an examination and was surprised at the difference. It is still enlarged but seems to be shrinking daily. I had experienced extreme, debilitating fatigue during the course of the illness and my appetite was severely depressed. I had lost 40 pounds in about 4 months time. I've noticed a terrific increase in my energy levels and my appetite has returned. I've gained back about 10 pounds and have starting participating again in the sports that I missed so much. I would like to mention that the doctors have told me that about 70% of patients with Sarcoidosis go into remission at some point. That may be the case with me, but I personally believe that the CMO played a major part in my recovery. This is the first time I have ever felt strongly enough about any product to give a testimonial but I have been extremely pleased and thankful for the experience that I had with your product.

Best Regards, Mark Howell (North Carolina)

Nov. 21, 2000 Dear Marge, I've procrastinated far too long, so I'm taking this opportunity to tell you what a wonderful relief of pain I have had from your products. The CMO products are like a miracle from God. My neck, hips and lower spine have improved 100%. It took one month and a half to feel some relief but in another month I am honestly 100%! My testimonial should encourage those who suffer today from joint pain and swelling, to use these products. They work! I owe these pain free days to CMO. Yours Truly, M. Stephanie Whaley (Surprise, AZ) Note: Ms. Whaley used CMO capsules in Feb. 2000. Her November testimonial is indicative of the many who report they are still pain free 8 or more months after using CMO products.

January 5, 2000 Dear Marge, I first ordered CMO Cream for my granddaughter who has an inherited condition on her feet that no doctor has been able to clear up. Within a few days of applying the cream her feet look perfect and don't itch. My two sons who also have the same trouble (inherited from their father) started using the CMO cream and after just three applications saw a marked improvement and kept telling me they can't believe the condition their feet are in now. Thank you, Pauline M. Harrington paulmlh@aol.com (New Jersey)

Date: Tue, 14 Dec 1999 06:31:56 +0000 From: Fredette arkdette@earthlink.net Subject: cmo/sarcoid This morn I took my last dose of CMO+...my husband asked me the other morning, "How do you feel?" and I said, "Good!" He said he couldn't remember the last time I had said that! Last week was my "3-day" teaching week and usually I am a wet noodle on Thursday from teaching 3 days in a row...but this Thursday I enjoyed putting Christmas decorations up! I still have been trying to take it easy, although my bevery impulse is to dive back into 'normal' life. I have some stiffness in my ankles in the morning, still, but since that was the first place I ever felt pain, perhaps that will be the last to go. I have taken 1 motrin over the past ten days...I used to take 3 every 4-6 hours! But I could have lived with the pain...the thing that was the hardest for me was the extreme fatigue that literally took me out of life. I must admit, I am still in a tentative, waiting sort of posture...I just want to see that I really am healing, rather than in body-self attack mode. Kathleen Fredette (Palmdale, CA) Note: Kathleen had a sarcoidosis flare up in May, 2000 and another one in Oct. 2000. Both times she took one bottle of CMO+ and then returned to her normal routine without needing pain medication or other drugs. Kathleen is thirty something and the mother of 4 young sons as well as a teacher.

Date: Wed, 22 Sep 1999 12:14:35 -0400 From: Viva J. McKinney vmckinne@bellsouth.net Dear Marge, I am writing a testimonial about my husband's experience with CMO+. I would very

much appreciate it if you would pass this information along to others that may have any doubts about its curative powers. In January of this year (1999) my husband was diagnosed with rheumatoid arthritis by three doctors at our nearby clinic. This disease hit him very hard and very fast. At first he was put on Prednisone to ease his pain and swelling while we waited for test results. In the meantime, I got on the internet to find out more about the disease and what treatments are available. I was rather alarmed about the facts I was reading on the toxicity of medications like Prednisone and Methotrexate. Methotrexate was described as one of the most toxic drugs on the planet. That's when I "happened" across Marge Berger and CMO. I contacted Marge for further information and read the book giving details of how CMO came into being, along with many testimonials. We went back to the clinic at that time and the "Specialist" wanted to put him on Methotrexate and launched into a diatribe of how safe a drug it is! We left the clinic with pills in hand, but I'm happy to say he never took them. We decided it would be worth it to take the CMO capsules before contaminating his body with toxic drugs. He was in great pain and had to wear three pairs of socks and wrist braces just to be able to continue working. He would literally drag himself out of the car and hobble into the house after work and collapse on the bed until the next morning. Because of our finances he was forced to continue working but was only able to endure about 20 hours per week. Then came the miracle of CMO! The four bottles my husband took have brought him back to 90-95% of what he was before he became ill. Now he can work a full day with no braces or extra socks. Through the four treatments the pain and swelling would come and go. He had good days and bad days and there were times we wondered if it was really working at all. But he stuck with it and now we are looking forward to his retirement and freedom from this crippling, life altering disease. An extra bonus is that his lower back problem of many, many years has also benefited from the CMO. We look forward to a hopeful future in our retiring years. Sincerely, WT and Jean McKinney (Georgia) Date: Tue, 29 Jun 1999 12:18:02 -0500 (EST) From: grants@mail.zimlink.com Dear Marge, It's Mavis Grant from Zimbabwe. Just a little note to share the good news with you about Beverley Scrooby. She has finished the courses of the CMO and has since had blood tests which show that she now has no trace of arthritis! I also wanted to thank you for all your help over the last couple of months! Thanks again. Regards Mavis Grant

From: EEJR1@aol.com Subject: Re: Sarcoid update - July, 1999 Dear Marge, Just wanted to email you and let you know that David is still fine. You recall I wrote you when he recovered from that horrible sarcoidosis in December of last year. Well, it has been seven months now, and he is still at 100 percent fine. We have told so many people about this wonderful product, CMO! Many have tried the product based on actually SEEING the wonderful recovery from what was a near-death situation! I still have trouble understanding that he only took the CMO for ten days and on the eleventh day, he felt about 80 percent recovered. Within the next few days, he was out roller-blading with the kids! I ordered another bottle of CMO for him, but he has never needed to take it. So we are keeping it on hand if any of us should ever have

a similar disorder (as insurance!.) Just wanted to give you an update, Marge! Thanks again, Elizabeth Rawlins ( Pensacola, Flordia)

Date: Mon, 10 May 1999 20:20:52 -0400 From: Terry Hicks kegler@cybergap.net Just wanted to let you know I have seen an 80 percent improvement since taking your CMO. My hand and wrist pain is down to a small ache after bowling whereas after 3 games before I couldn't even pick up a ball the next day. Now I can bowl back to back days and even more if needed. My knees which had cartilage removed and ached during walks have improved also. I really doubted CMO's claims but was desperate and it really did work. I tried MSM but seen no improvement with them alone but I did continue taking them with the CMO. Terry Hicks (Pensylvania)

Date: Thu, 11 Mar 1999 12:50:50 +0800 From: Alicen Spencer alicenjohn@telstra.easymail.com.au Dear Marge, Just a quick note to thank you for sending over the CMO product to us, my fiance has appeared to have recovered extremely well and to this date has had no pain whatsoever for the past 2 weeks solid. This result is after having taken the second dosage of what we ordered from you. We would just like to thank you very much and state that it is quite like a miracle product. For your information, we have passed on several of your brochures and details and so far 5 other acquaintances of ours have purchase and commenced using CMO. Nothing better than 'word of mouth' promoting. Good luck with an excellent product. Thanks again. Alicen Spencer [ on behalf of John Bosco ] (Australia) Note: John is a young man whose chronic joint pain and stiffness was secondary to a major auto accident a few years before. 6 months after the message he was still pain free. Have not heard from him since.

Notice: Not all users have the same results as the authors of these testimonials. Human response can vary greatly due to a variety of complex health and human genetic factors. Those taking immune suppressing medication, those with liver disease and those with a low thyroid condition (untreated) usually do not benefit from CMO+ products.
The statements on this web site have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. who we are | cmo+ facts | testimonials | order

Friday, November 22, 2013

My name is Marge Berger. My company, PermaHEALTH Inc, was originally set up 14 years ago as a company for nutritional consultations generated primarily by MD referrals. However, due to the overwhelming response to our CMO product line, the company focus has shifted to managing our web generated nutrition marketing business. We evolved into an internet company in 1996 after discovering CMO for our uncle who was an 84 year old widower at the time. He had painful crippled hands and could not take any medication other than NSAIDs due to his glaucoma. The NSAIDs no longer worked and his doctor said immune suppressants were out of the question. He asked me to use my nutrition training to find help for his pain. A tough assignment! I found CMO on one obscure web site. I was very skeptical. At that time (1996) CMO cost $275.00 for 50 capsules. WOW! Uncle Wilbur said any price was not too high if it helped. Three days after the CMO arrived in his home in PA he called to say his hands had not felt this good in 20 years. He told me he was able to use the wrench that had been sitting on his desk for 2 years waiting to fix a loose bolt on his lamp. Every other time he had tried to squeeze the wrench (even after soaking his hands in hot water) the pain would not allow him to complete this simple task. He finished 2 bottles of CMO, though after only one bottle he was able to return to all his chores and hobbies that had been put 'on hold' when NSAIDS no longer worked. He was able to hang his laundry outside on the line again (he claimed dryers were a luxury that used too much electricity). He opted for the second bottle for what he said was "insurance". The 2 bottles cost him $550 - 3 times what 2 bottles cost today in the year 2000. He told me 2 years later that it was worth every penny. Before we bought the product for our beloved uncle, we checked the article written by scientist, Dr. Harry Diehl, who was working at the National Institutes of Health at the time (early 1970's) he discovered the benefits of injectable CMO on the arthritic joints of mice. His article appeared in the Journal of Pharmaceutical Sciences,(VOL 83, #3, March 1994, pages 296299) and had been written at the insistence of his doctor who was amazed at the researcher's personal results when he had inject his own arthritic joints from CMO he extracted in his home lab long after he retired from NHI. Then we called Dr. Sands who reported that, yes, he and his researchers had indeed created the oral analog of CMO from Diehl's research. He said he himself had taken the CMO capsules for his knees the year

before and was now no longer dependent on pain medication and could walk anywhere and even climb stairs. After seeing Uncle Wilbur's continued joy in living and after giving a few more bottles to friends and relatives who had similar results, I decided to market CMO. The results reported by the early users were generally excellent. This product was indeed a marvel! Hence our website http://www.bestcmo.com evolved. I visited Dr. Sands in his clinic in Oct. 2000. He was still mostly free from pain, and more importantly ddi not need to constantly take pain medication (even 6 years after he originally took CMO). I cannot promise you that our Duoflex CMO+HPR will work the same way for you because all bodies are complex and respond differently to products. I can promise you that if you are not satisfied with your results, I will refund your product purchase price. To date we have a 10% refund rate. That says that 90% of our customers are happy with their results. We have improved on the original product by adding appropriate proprietary digestive enzymes to aid in better assimilation of the CMO joint formula. We have also combined it with the fantastic homeopathic pain reliever, HPR. Together Duoflex CMO+HPR are helping many arthritics who had resigned themselves to daily pain medication and limited lifestyles. This new combination of products is rapidly becoming the leader in this field. If you need a refund please wait 30 days after finishing our products to evaluate your overall results.

Why should I wait 30 days?

For some customers the response is slow but just as rewarding. Because Duoflex CMO+HPR is not a pain relief drug, the benefits can be subtle at first. As days go by you may begin to notice your "quality of life" is back. You smile and realize you are feeling younger, moving faster, walking farther, sleeping better, and forgetting to swallow those pain pills. All in all, life is good again. Thank you for considering our product and please contact me if I can be of help as you continue to research to make an informed decision. Wishing you healthy and happy days ahead.

Marge Berger, Nutritionist

PermaHealth Inc P.O. Box 653 Emmaus,PA 18049 USA 843.838.4672 - 800.224.8912 email: info@bestcmo.com
The statements on this web site have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. who we are | cmo+ facts | testimonials | order

SAN DIEGO CLINIC

THE FIRST TRIALS THE SAN DIEGO STUDY: An informal human study was undertaken at a facility called the San Diego Clinic in late 1995. It was conducted by Dr. Len Sands, Ph.D. It started with some stated objectives: THE QUESTIONS TO BE ANSWERED WERE: 1. What are the optimum dosage levels for treating the various types of arthritis with CMO? 2. Are different dosages important relative to the different types of arthritis? 3. What is the lag time between the start of the treatment and the expected relief of symptoms? 4. What percentage of patients respond to the treatment? 5. What factors, if any, contribute to non-responsiveness? The study was conducted with 48 volunteer patients who had (OA) osteoarthritis, (RA) rheumatoid, and (PA) psoriatic arthritis. The group was comprised of 28 females and 20 males ranging from 32 to 82 years of age. All races and all ethnic backgrounds were represented. Age, gender, race and ethnic background appeared to be irrelevant to the results of the program. CMO was administered orally in the form of 385 mg capsules. The number of capsules and duration of treatment varied for each group. The final protocol will be found later in this study. At the end of each trial an evaluation was made using three parameters; inflammation, pain and motion. All but four of the subjects in the studies reported 80% to 100% return of articular mobility as well as 70% to 100% decrease in pain. Probably the most interesting finding was that the relief of inflammation frequently resulted in partial correcting of the deformities. In some cases it resulted in complete corrections. At the end of the entire study, only two subjects said they had failed to notice any change. An examination confirmed no changes in the pair. These two non-responders had prior hepatic problems, one from alcohol abuse resulting in cirrhosis of the liver and the other had abused steroids for the purpose of bodybuilding. It was concluded, then, that liver damage may have been the cause of the failures. This could, at least, be a working hypothesis for future study. Two other patients showed less than 75% return of articular mobility. During the entire study and follow-up, there were no discernible side effects. This was an informal and independent trial at a private medical clinic. It was undertaken by an individual doctor and other professionals without funding from the government or drug companies. Clinical studies such as these point out fruitful directions for future studies. GROUP 1 Eleven (11) subjects, was comprised of mild to moderately severe osteoarthritis, including one case of reactive psoriatic arthritis. The eleven subjects took two capsules of CMO twice daily for five days and quit. That was the entire treatment. Nine of the patients reported 20% to 30% improvement in articulation and inflammation and about 40% to 50% relief of arthritic pain within 36 hours. Improvements, in the same nine, continued rapidly for the next 60 hours, reaching 80% to 100% overall relief by the end of four days. The two remaining subjects reported a 70% to 80% improvement by the end of the fourth day, and both of them continued to see improvements over the next week even though they were no longer on the capsules. Half of this entire group experienced a return of some mild arthritic symptoms after about 3 to 5 weeks following the study. All of them were re The patient with reactive psoriatic arthritis also experienced an almost complete reversal of his arthritis as well as his associated severe psoriatic skin condition which affected about 20% of his total skin area.

GROUP 2 Nine patients (9) with severe rheumatoid arthritis were grouped together for a second study. Four patients in this group required wheelchairs. One of the patients was on crutches because of a hip fusion. The remaining 4 needed walkers or canes. All of them had pain, inflammation and marked deformations of all the joints in the fingers as well as restriction of motion. Five had some permanent lower back flexion as well as back pain. All of the patients in this study had difficulty grasping and manipulation common objects. The dosage schedule was two 385 mg capsules twice a day for 7 days, then stop for 7 days and then resume for 5 and 1/2 days. Within three days, six in this group reported a 30% to 50% decrease in pain. Three of the six noticed increased joint mobility, and another three subjects reported little change. In 7 days, five of the patients had a 70% to 90% decrease in pain and 70% to 80% improvement in joint mobility. Three reported themselves to be totally free of pain with almost complete return of joint mobility. The joint deformations which were previously severe seemed to show marked improvement. Only one failed to show changes. After they had been off treatment for a week, roughly half said they had seen further improvements, but most of it was minor. Two of the patients stayed the same. There was no improvement in the individual who had not seen improvement from the start. They were then re-treated for another 5 days. By the end of the treatment period all but two subjects reported themselves to be 90% free of pain, with 70% to 90% improvement in joint mobility. The non GROUP 3 Group 3 consisted of 14 subjects with severe rheumatoid arthritis. They were given two 385 mg capsules of CMO twice a day for six days and then nothing. After three days, eleven out of this group had 40% to 50% improvement in articulation and inflammation and 40% to 50% improvement in arthritic pain. All improved rapidly over the next four days, approaching 80% to 100% level. The remaining three had 70% to 80% improvement after seven days, Most of the subjects continued to experience minor improvement during the first week off the treatment. Six patients, however, noticed some minor recurrence three or four weeks after the treatment and were retreated in the same manner. Their symptoms disappeared. GROUP 4 The fourth group organized contained 14 subjects severely crippled with osteoarthritis. They each took two 385 mg capsules of CMO twice a day for seven days, then off seven days, then back on for five and a half days. At the onset, three of this group were unable to walk and required wheelchairs. The other eleven used walkers, canes or crutches. All of the patients in this group had pain, inflammation and deformations throughout their hands and fingers. Four of the patients had severely limited movement of their backs and lower back pain. Ten had difficulty grasping and holding objects. Four days later, ten of the patients reported a 30% to 50% improvement in movement and lessening of inflammation. 40% to 50% of their pain was gone. Ten of them continued to see Improvement over the next 3 days. In seven days they were 80% to 100% better. One subject showed no change. On the 14th day, at the end of their week off treatment, 9 had continued to feel improvements. Four stayed the same and the one who had failed to improve before stayed the same. They re-started the CMO again for five and a half more days. At the end of the treatment, eleven had 80% to 100% improvement in pain and mobility. Two had 70% to 80% improvement in mobility and 70% to 90% lessening of pain. One patient, the same as before, experienced no relief. CONCLUSIONS OF THE STUDY The optimal dosage level appears to be equal for all three types of arthritis:

Osteoarthritis, Rheumatoid and Psoriatic Arthritis. This is evidenced by the gradual return of minor arthritic symptoms in several of those treated with only 16 to 24 capsules, and no regression in those treated with 50 capsules in two series separated by one week without treatment. Dosage level requirements appear to be equal irrespective of the severity of the subject's condition. Initial response time for minor improvement appears to vary from two to seven days irrespective of the severity of the subject's condition. The time for maximum attainable response appears to be from seven to twenty-one days, resulting in 70% to 100% overall improvement. (Apart from the study three of the most severely afflicted subjects were treated again after a five week interval resulting in an additional 10% to 20% overall improvement.) The two non-responding subjects both proved to have suffered previous damage to the liver from steroid or alcohol abuse, indicating that impaired liver function may preclude success with this protocol. In addition, it was evident that for many subjects the relief of inflammation resulted in marked improvement in joint deformation. There were no side effects of the treatment noted by the subjects or the doctors. Some of the patients were not entirely happy with 70% improvement and so were re-treated 5 weeks later. In general, they benefited another 10% to 20%. There are, in addition to these studies, hundreds of testimonials and success stories. And the success rate in most cases, if you count success as being a substantial improvement in symptoms, is an astonishing 98% and all of this without risk to the patient. This concludes these studies and their results.

SAN DIEGO CLINIC

MEMORANDUM Subject: Heart Disease Relative to CMO There have been no formal studies conducted with respect to the effects of CMO on individuals with heart disease. However, considering that CMO is a naturally derived nutritional supplement that has shown to help normalize various physiological and immunological body processes in humans, and since it appears to be completely non On the contrary, we have received interesting reports regarding persons with certain other ailments who have taken CMO for arthritis as recommended by their physicians and other health care professionals. 1. There have been reports on individuals suffering from hypertension (high blood pressure) whose blood pressure has completely normalized or lowered substantially. 2. There have been reports of individuals suffering from hypotension (low blood pressure) whose blood pressure has completely normalized or raised substantially. 3. There have been reports of individuals with high and even extremely high blood sedi-mentation rates whose sed rates have normalized, even in Lupus patients. 4. There have been reports of individuals with cardiac arrhythmia (abnormal heartbeat rhythm) whose arrhythmia has disappeared. Those reports are not the result of any formal study. They have been noted from comments provided to us by professionals who have been surprised at these secondary benefits of CMO which they have encountered in their patients during the treatment for arthritis. This tendency by CMO to normalize body processes confirms that it functions as an immunomodulator. It must not be assumed that other patients will enjoy these same secondary benefits. No formal studies have been conducted to confirm that these benefits are repeatable on a consistent basis.

It must be emphasized that any individual with a serious ailment or condition of any sort should consult with and be closely monitored by their relevant health care professional any time that person undertakes any sort of therapeutic or even nutritional program. January 1997

SAN DIEGO CLINIC

MEMORANDUM Subject: CMOTM . and Horses Our very first experience with horses involved a 19-year-old dressage stallion who is considered to be the best stud horse of that kind on the East Coast. The owners were distressed that the stallion was so severely afflicted with arthritis that he was unable to move out of his stall, much less participate in dressage practice or performances. In addition, the horse was not able to rest well because of the arthritic pain. Equally distressing was the fact that he could no longer perform his breeding duties without resorting to complicated artificial insemination procedures. We are happy to report that after the administration of four bottles of CMO the stallion was waking in the morning refreshed and free of pain and able to practice its dressage maneuvers. Furthermore tic returned quite comfortably to breeding in the natural way. Needless to say, the owners were overjoyed - and we bet the stallion was too. Another interesting case involved a 14-year-old mare who had become too lame to walk. In all three years of working with the horse, her trainer found that she had never been able to canter and sometimes just barely managed to trot. The mare had very distinct bulging in the tendons her lower front legs. After two bottles of CMO, the horse was no longer lame and the swollen bulges had disappeared. The mare was able to trot comfortably and even canter again for the first time in years. On a ten point scale estimating pain relief and mobility, the trainer estimated that the horse had improved form a 2.5 level before CMO to a 7.5 level after. More subtle improvements were evident in a case involving another dressage horse that was progressively becoming more and more resistant to a right lead. In this instance the trainer had already experienced great results with CMO for her own neck and shoulder problems, probably the result of being hauled around an arena by 1000 pound animals for so many years. So why not try CMO on the horse as well? Even before finishing the second bottle the horse lost all resistance to the right lead and showed a marked increase in fluidity of motion which is so important in dressage work. One horse was conclusively diagnosed as suffering from arthritis by x-ray which clearly revealed the presence of arthritic bone spurs. After administering three bottles of CMO the owner reports that the bone spurs have decreased in size and are disappearing. We are hoping soon to support the visual evaluation with X-Ray confirmation as well. We recently submitted blood samples of a horse undergoing treatment with CMO for the standard analysis required on the show horse circuit in California. Nothing unusual appeared in the analysis. Administering CMO to horses call sometimes be a problem with finicky caters. Some owners use a ball gun with great success, but some owners prefer to mix the contents of the capsules in with something of which the horse is particularly fond. Some find that applesauce works well. Others like grated carrots and apples. A commercial oat and molasses mixture often works well too. About 20 capsules a day seem to work well for an average size horse. CMO has been effective an cats, dogs, hamsters, and pot-bellied pigs for arthritis and hip dysplasia as well. Small animals need only one capsule daily. Two capsules daily for each 50 pounds of body weight.

Other Studies:
San Diego Clinic: The First Trials CMO Testing by Medisure A Randomized Clinical Trial The Effects of Fish Oil on Rheumatoid Arthritis What Is Psoriatic Arthritis?

CMO Testing by Medisure

Medisure supplied sufficient IMUNALL (brand of CMO) to Advanced Medical Systems & Design, Ltd. for a two year field study on the effectiveness of their "natural nutritional compound", Cerasomal-cis-9-cetylmyristoleate (CMO), which had after earlier research and testing by Medisure, shown to be effective in relieving the adverse symptoms of arthritis and perhaps other immune system disorders. The main thrust of this battery of tests was primarily focused on arthritis. The study involved 888 female subjects ranging in age from 28 to 82, and 926 male subjects ranging in age from 29 - 74. All races and many ethnic backgrounds were represented. Age, gender, race, and ethnological background appeared to be irrelevant to patient response in this study. However, younger subjects seemed to respond earlier to the regimen program. CMO was administered orally in the form of three capsules each morning and evening until the 96 capsules were consumed for 16 days. The subjects were examined on the eighth and sixteenth day for evaluation regarding pain, swelling and inflammation. Encouraging results were found after testing the 1,814 subjects. The results showed that over 87% of the subjects had greater than 50% recovery and over 65% of those showed from 75% 100% recovery following a sixteen day regimen. All types of arthritis were positively affected by CMO. Studies showed improvement in all subjects except those who had suffered liver damage or those with digestive problems or disorders. Otherwise, every patient benefited. Initial response times for minor improvement varied from two to seven days irrespective of the subject's condition. Approximately 95% of the subjects who had favorable response did so within the first 10-day period. The other approximately 5% showed favorable results after a regimen of 16 days and therefore would derive the greatest benefit from a full 20-day regimen of two bottles (120 capsules). It is the opinion of Dr. Ricky Allen,(managing director of Advanced Medical Systems and Design, Ltd.), that the new dosage/regimen recommendation be a 60 capsule, 10-day program. This new regimen would give maximum benefit for the greatest percentage of subjects.

Other Studies:
San Diego Clinic: The First Trials CMO Testing by Medisure A Randomized Clinical Trial The Effects of Fish Oil on Rheumatoid Arthritis What Is Psoriatic Arthritis?

Long-Term Fish Oil Supplementation Benefits RA Patients

LEUVEN, BELGIUM. Belgian researchers have released the results of a major study aimed at determining the long-term effects of fish oil supplementation in rheumatoid arthritis patients. Sixty patients completed the year-long, double-blind, randomized study. The participants were divided into 3 groups with 1 group receiving a daily supplement of 6 capsules containing 1 gram of olive oil each (placebo); another group receiving 3 olive oil capsules plus 3 fish oil capsules (containing 1 gram of fish oil each); and the third group receiving 6 fish oil capsules daily (corresponding to 2.6 grams/day of omega-3 fatty acid). All patients continued on their regular arthritis medications.

Three months into the study it became clear that the patients on fish oil alone had improved considerably when compared to the other 2 groups and this improvement became even more pronounced after 12 months of supplementation. Fifty-three per cent of the patients in the fish oil group showed significant overall (global) improvement as compared to 10% in the placebo group and 33% in the fish oil plus olive oil group. Fortyseven per cent of the patients in the fish oil group were also able to reduce their intake of NSAIDs and disease-modifying anti-rheumatic drugs as compared to 15% in the placebo group and 29% in the olive oil plus fish oil group. The researchers conclude that long-term supplementation with fish oils benefits rheumatoid arthritis patients significantly and may lessen their need for NSAIDs and other RA medications. Geusens, Piet, et al. Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis. Arthritis & Rheumatism, Vol. 37, June 1994, pp. 824-29

Borage and Fish Oils Go Together

JACKSONVILLE, FLORIDA. Supplementation with gammalinolenic acid (GLA) found in borage and evening primrose oils reduces the symptoms of chronic inflammatory diseases such as rheumatoid arthritis and atopic dermatitis. It is believed that the transformation of GLA to DGLA (dihomo-gamma- linolenic acid) in the inflammatory cells (white blood cells) helps dampen the inflammatory effects of AA (arachidonic acid). Unfortunately, there is a fly in the ointment. While GLA supplementation results in a decrease in AA in the inflammatory cells it also causes, somewhat paradoxically, a very significant increase in AA in the blood serum itself. A high blood level of AA is associated with an increased risk of blood clotting and is a potent risk factor for heart disease.

Researchers at the Mayo Clinic now report that the potentially harmful effects of GLA supplementation can be eliminated by simultaneous supplementation with fish oil. Their small clinical trial involved a control group of 2 healthy men and 2 healthy women who consumed a controlled diet while supplementing with 3 grams/day of GLA (5 capsules of borage oil morning and evening). The active treatment group (5 women and 7 men) followed the same protocol with the addition of 3 grams/day of EPA (eicosapentaenoic acid) taken in the form of 5 capsules of concentrated fish oil (each capsule containing 600 mg of EPA and 280 mg of DHA (docosahexaenoic acid). After 3 weeks of supplementation samples of white blood cells and samples of blood serum were analyzed to determine fatty acid profiles. Both groups experienced a marked increase in beneficial DGLA in their white blood cells. The control group (GLA supplementation only) also saw a significant increase in detrimental AA in their blood serum, but no such increase was observed in the group taking fish oil as well. The researchers conclude that the detrimental effects of GLA supplementation can be avoided by adding fish oils to the supplementation regimen. Barham, J. Brooke, et al. Addition of eicosapentaenoic acid to gamma-linolenic acid: supplemented diets prevent serum arachidonic acid accumulation in humans. Journal of Nutrition, Vol. 130, 2000, pp. 1925-31

Fish Oils Recommended For Rheumatoid Arthritis

NEWCASTLE, AUSTRALIA . At least 13 published randomized, controlled clinical trials have reported significant benefits of fish oil supplementation in rheumatoid arthritis patients. Now researchers at the University of Newcastle weight in with the additional evidence to support these earlier findings. Their 15week study involved 50 patients who had been diagnosed with rheumatoid arthritis. The patients were all consuming a diet which contained less than 10 grams/day of omega-6 fatty acids. These fats are known to promote inflammation through their eicosanoid metabolites. Half the patients were given fish oil capsules to provide a daily intake of 40 mg/kg body weight (about 2.8 grams for a 70 kg person); the other half received placebo capsules containing 50/50 corn/olive oil. All subjects continued with their regular diet and medications. About half the patients dropped out during the experiment, mainly due to changes in their medications. Complete clinical evaluations were carried out at baseline, 4, 8 and 15 weeks. There were no significant changes after 4 or 8 weeks, but at the 15-week evaluation major improvements were noted in the group receiving fish oil. Particularly impressive were the improvements in the duration of morning stiffness and the overall assessment of disease activity (by both patients and physicians). Significant improvements were noted in 6 of the 9 evaluation parameters in the fish oil group; no improvements were noted in the control group. Only the total number of joints affected, the erythrocyte sedimentation rate (ESR), and the Creactive protein level were unaffected by supplementation.

In an accompanying editorial Drs. Cleland and James of the Royal Adelaide Hospital emphasize the importance of maintaining a low intake of omega-6 fatty acids in order to keep the ratio of omega-6 to omega-3 as low as possible. They conclude that "dietary fish oil supplements should now be regarded as part of standard therapy for rheumatoid arthritis". Volker, Dianne, et al. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis. Journal of Rheumatology, Vol. 27, October 2000, pp. 2343-46 Cleland, Leslie G. and James, Michael J. Fish oil and rheumatoid arthritis: antiinflammatory and collateral health benefits. Journal of Rheumatology, Vol. 27, October 2000, pp. 2305-06 (editorial)