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Morpholine (cas 110-91-8) MSDS

1. 1.1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product identifiers
Product name Product Number Brand Index-No. CAS-No. : : : : : :

morpholine
252360 Anonymous-Anonymous 613-028-00-9 110-91-8 Laboratory chemicals, Manufacture of substances

1.2 2. 2.1

Relevant identified uses of the substance or mixture and uses advised against
Identified uses

HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Flammable liquids (Category 3) Acute toxicity, Inhalation (Category 4) Acute toxicity, Dermal (Category 4) Acute toxicity, Oral (Category 4) Skin corrosion (Category 1B)

Classification according to EU Directives 67/548/EEC or 1999/45/EC

Causes burns. Flammable. Harmful by inhalation, in contact with skin and if swallowed.

2.2

Label elements Labelling according Regulation (EC) No 1272/2008 [CLP]

Pictogram Signal word Hazard statement(s) H226 H302 H312 H314 H332 Precautionary statement(s) P280 P305 + P351 + P338 P310 Supplemental Hazard Statements Hazard symbol(s) R-phrase(s) R10 R20/21/22 R34 S-phrase(s) S23 S36 S45 Danger Flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Causes severe skin burns and eye damage. Harmful if inhaled.

Wear protective gloves/ protective clothing/ eye protection/ face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/ physician. none

According to European Directive 67/548/EEC as amended.

Flammable. Harmful by inhalation, in contact with skin and if swallowed. Causes burns. Do not breathe gas/fumes/vapour/spray. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

2.3 3.

Other hazards - none COMPOSITION/INFORMATION ON INGREDIENTS

3.1

Substances
Synonyms Formula Molecular Weight Component : : : Tetrahydro-1,4-oxazine C4H9NO 87,12 g/mol Concentration 110-91-8 203-815-1 613-028-00-9 -

Morpholine
CAS-No. EC-No. Index-No.

4. 4.1

FIRST AID MEASURES Description of first aid measures General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2

Most important symptoms and effects, both acute and delayed

Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, Nausea

4.3 5. 5.1

Indication of any immediate medical attention and special treatment needed

no data available

FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 5.3 5.4 6. 6.1

Special hazards arising from the substance or mixture

Carbon oxides, nitrogen oxides (NOx)

Advice for firefighters

Wear self contained breathing apparatus for fire fighting if necessary.

Further information
Use water spray to cool unopened containers.

ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.

6.2 6.3

Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Methods and materials for containment and cleaning up

Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 7. 7.1

Reference to other sections

For disposal see section 13.

HANDLING AND STORAGE Precautions for safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.

7.2

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Hygroscopic.

7.3 8. 8.1 8.2

Specific end uses

no data available

EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment Eye/face protection

Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

9. 9.1

PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties
a) Appearance b) Odour c) Odour Threshold d) pH e) Melting point/freezing point f) Initial boiling point and boiling range Form: liquid Colour: colourless unpleasant no data available 10,6 at 5 g/l at 20 C Melting point/range: -7 - -5 C - lit. 126,0 - 130,0 C

g) Flash point 31 C - closed cup h) Evaporation rate no data available i) Flammability (solid, gas) no data available j) Upper/lower flammability or explosive limits k) Vapour pressure l) Vapour density m) Relative density n) Water solubility o) Partition coefficient: noctanol/water p) Autoignition temperature q) Decomposition temperature Upper explosion limit: 10,8 %(V) Lower explosion limit: 1,8 %(V) 41 hPa at 38 C 9 hPa at 20 C 3,01 - (Air = 1.0) 0,996 g/cm3 at 25 C completely miscible log Pow: -2,55 no data available no data available

r)

Viscosity

no data available no data available no data available

s) Explosive properties t) Oxidizing properties

9.2

Other safety information

no data available

10. STABILITY AND REACTIVITY 10.1 Reactivity

no data available

10.2 Chemical stability

no data available

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

Heat, flames and sparks.

10.5 Incompatible materials

Strong oxidizing agents

10.6 Hazardous decomposition products

Other decomposition products - no data available

11. TOXICOLOGICAL INFORMATION 11.1 Information on toxicological effects Acute toxicity

LD50 Oral - rat - 1.450 mg/kg LC50 Inhalation - rat - 8 h - 8000 ppm LD50 Dermal - rabbit - 500 mg/kg

Skin corrosion/irritation
Skin - rabbit - Severe skin irritation - 24 h

Serious eye damage/eye irritation

Eyes - rabbit - Severe eye irritation

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

Genotoxicity in vitro - mouse - lymphocyte Morphological transformation. Genotoxicity in vitro - Hamster - ovary Sister chromatid exchange

Carcinogenicity
Carcinogenicity - mouse - Oral Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax, or Respiration:Bronchiogenic carcinoma. Liver:Tumors. This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification. IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Morpholine)

Reproductive toxicity
no data available

Specific target organ toxicity - single exposure

no data available

Specific target organ toxicity - repeated exposure

no data available

Aspiration hazard
no data available

Potential health effects Inhalation Ingestion Skin Eyes

May be harmful if inhaled. Material is extremely destructive to the tissue of the mucous membranes and upper respiratory tract. Harmful if swallowed. Causes burns. Toxic if absorbed through skin. Causes skin burns. Causes eye burns.

Signs and Symptoms of Exposure

Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, Nausea

Additional Information
RTECS: QD6475000

12. ECOLOGICAL INFORMATION 12.1 Toxicity

Toxicity to fish Toxicity to daphnia and other aquatic invertebrates Toxicity to algae LC50 - Oncorhynchus mykiss (rainbow trout) - 180 - 380 mg/l - 96 h EC50 - Daphnia magna (Water flea) - 100 mg/l - 24 h

Growth inhibition LOEC - Desmodesmus subspicatus (green algae) - 80 mg/l 72 h EC50 - Desmodesmus subspicatus (green algae) - > 310 mg/l - 72 h

12.2 Persistence and degradability

Biodegradability

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Results of PBT and vPvB assessment

no data available

12.6 Other adverse effects

no data available

13. DISPOSAL CONSIDERATIONS 13.1 Waste treatment methods Product

Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging
Dispose of as unused product.

14. TRANSPORT INFORMATION 14.1 UN number

ADR/RID: 2054 IMDG: 2054 IATA: 2054

14.2 UN proper shipping name

ADR/RID: MORPHOLINE IMDG: MORPHOLINE IATA: Morpholine

14.3 Transport hazard class(es)

ADR/RID: 8 (3) IMDG: 8 (3) IMDG: I IMDG Marine pollutant: no IATA: 8 (3) IATA: I IATA: no

14.4 Packaging group

ADR/RID: I

14.5 Environmental hazards

ADR/RID: no

14.6 Special precautions for user

no data available

15.

REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available

15.2 Chemical Safety Assessment

no data available

16.

OTHER INFORMATION Further information

The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information this document is based on the resent state of our knowledge and is applicable to the product with regard to appropriate safety precautions.

of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. guidechem shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.