BACHELOR OF MEDICINE AND BACHELOR OF SURGERY (MBBS) (SECOND YEAR) PHARMACOLOGY TUTORIALS MODULE: FUNDAMENTAL MDC 201 Tutori

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Dr# R $$o% &' Mr#Lo%' M(# S) *+ &i

OCT 201, SESSION

1# What does the term antibiotic mean: a) Non-organic or synthetic substances that selectively kill or inhibit growth of other microorganisms b) Substances produced by microorganisms and their synthetic analogues that selectively kill or inhibit growth of other microorganisms c) Substances produced by microorganisms and their synthetic analogues that inhibit growth of organisms d) Synthetic analogues of natural substances that kill proto oa and helminths 2# !eneral principles of anti-infective therapy are: a) "linical #udgment of microbiological factors b) $efinitive identification of a bacterial infection and the microorganism%s susceptibility c) &ptimal route of administration' dose' dosing fre(uency and duration of treatment d) )ll of the above ,# *ational of using antimicrobial combination is used to: a) +rovide synergism when microorganisms are not effectively eradicated with a single agent alone b) +rovide broad coverage c) +revent the emergence of resistance d) )ll of the above 1# ,echanisms of bacterial resistance to anti-microbial agents are the following' E2CEPT: a) )ctive transport out of a microorganism or-and hydrolysis of an agent via en ymes produced by a microorganism b) .nlarged uptake of the drug by a microorganism c) ,odification of a drug%s target d) *educed uptake by a microorganism "# )ll of the following drugs are antibiotics' E2CEPT: a) Streptomycin b) +enicillin c) "o-trimo/a ole d) "hloramphenicol 3# 0actericidal effect is: a) 1nhibition of bacterial cell division b) 1nhibition of young bacterial cell growth c) $estroying of bacterial cells d) 2ormation of bacterial 3-form 4# Which of the following groups of antimicrobials demonstrate bactericidal effect4 a) 5etracyclines b) ,acrolides c) +enicillins d) )ll of the above 5# 0acteristatic effect is: a) 1nhibition of bacterial cell division b) 1nhibition of young bacterial cells growth c) $estroying of bacterial cells d) 2ormation of bacterial 3-form 6# Which of the following groups of antimicrobials demonstrate bacteristatic effect: a) "arbapenems b) 5etracyclines c) )minoglycosides d) "ephalosporins 10# 5ick the antimicrobial belonging to macrolides: a) Neomycin b) $o/ycycline c) .rythromycin d) "efota/ime

11# 5ick the antimicrobial belonging to carbapenems: a) ) treonam b) )mo/acillin c) 1mipinem d) "larithromycin 12# 5ick the monobactams: a) )mpicillin b) "eftria/one c) ) treonam d) 1mipinem 1,# )ntimicrobials inhibiting the bacterial cell wall synthesis are: a) 0eta-lactam antibiotics b) 5etracyclines c) )minoglycosides d) ,acrolides 11# )ntimicrobials inhibiting bacterial *N) synthesis is: a) .rythromycin b) *ifampin c) "hloramphenicol d) 1mipinem 1"# )ntimicrobials altering permeability of cell membranes are: a) !lycopeptides b) +olymy/ins c) 5etracyclines d) "ephalosporins 13# )ll of the following antimicrobials inhibits bacterial protein synthesis' E2CEPT: a) ,acrolides b) )minoglycosides c) !lycopeptides d) 5etracyclines 14# Which of the following antimicrobial is gastric acid resistant: a) +enicillin ! b) +enicillin 6 c) "arbenicillin d) +rocaine penicillin 15# Which of the following antimicrobial is beta lactamase 7penicillinase) resistant: a) &/acillin b) )mo/acillin c) 0icillin-8 d) +enicillin ! 16# ,echanism of penicillin%s antibacterial effect is: a) 1nhibition of transpeptidation in the bacterial cell wall b) 1nhibition of beta-lactamase in the bacterial cell c) )ctivation of endogenous proteases' that destroy bacterial cell wall d) )ctivation of endogenous phospholipases' which leads to alteration of cell membrane permeability 20# "hoose the characteristic of chloramphenicol: a) 0road-spectum9 $emonstrates bactericidal effect b) 1nfluences the !ram-positive microorganisms9 $emonstrates a bactericidal effect9 c) 1nfluences the !ram-negative microorganisms9 $emonstrates a bactericidal effect9 d) 0road-spectum9 $emonstrates a bacteristatic effect9

21# "hloramphenicol has the following unwanted effects: a) Nephroto/icity b) +ancytopenia c) :epatoto/icity d) &toto/icity 22# "hoose the characteristic of vancomycin: a) 1t is a glycopeptide' inhibits cell wall synthesis active only against !ram-negative bacteria b) 1t is a glycopeptide' that alters permeability of cell membrane and is active against anaerobic bacteria c) 1t is a beta-lactam antibiotic' inhibits cell wall synthesis active only against +seudomonas aeruginosa d) 1t is a glycopeptide' inhibits cell wall synthesis and active only against !ram-positive bacteria 2,# 6ancomicin has the following unwanted effect: a) +seudomembranous colitis b) :epatoto/icity c) *ed neck syndrome d) )ll of the above 21# "ombination of sulfonamides with trimethoprim: a) $ecreases the unwanted effects of sulfonamides b) 1ncreases the antimicrobial activity c) $ecreases the antimicrobial activity d) 1ncreases the elimination of sulfonamides 2"# ./amples of synergism E2CEPT: a9 sulfametho/a ole;trimethoprim b9 amo/icillin;clavulanic acid c9 vancomycin;gentamycin d9 dalfopristin-(uinupristin