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butox
Intervet Egypt, S.A.E. 53, Abd Allah Ibn Taher st., Nasr city, Cairo - Egypt Tel.: +(202) 275 1102 - 275 1103 Fax: +(202) 275 1104

Tel.: 02 3350638 / Ref. B20504

NAGADA Graphics

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butox

The security of a long-lasting protection

DELTAMETHRIN, ACTIVE INGREDIENT OF

(It is one the pyrethroid group)

butox

butox

TECHNICAL DATA

butox

IN PRACTICE

butox is active against ticks, the mites responsible for mange, lice, flies and other insects that: impair the health of animals and reduce their yield. butox works on all parasitic stages of the life- cycle.
A PURE ANTIPARASITIC AGENT The pyrethroids are characterised by: their potency , markedly greater than of classical antiparasitic agents. their safety, resulting from the specificity of their antiparasitic action. their environmentally satisfactory biodegradability. It should be noted, however, that the products made available to stock- breeders do not constitute a well-defined homogenous group. With the exception of deltamethrin, every currently available pyrethroid is actually a mixture of molecules. These molecules are made up of the same constituent atoms, but have different arrangements in space. Chemists call this a mixture of isomers.

Composition: CHEMICAL NAME: (1R .3R)-3(2.2-dibromovinyl) -2,2 dimethylcyclopropane carboxylate of (s)--cyano-3- phenoxybenzyle. GENERIC NAME : deltamethrin. Each 1 ml of butox 50 EC contains 50 mg of Deltamethrin TOXICOLOGY The LD 50 of any product depends on the animal species tested and in any given species, on the solvent used. Pyrethroids are soluble in mineral and vegetable oils ,and practically insoluble in water , Orally they are most toxic when administered as an oily solution. They are not toxic at all , however, when administered in the from of an aqueous suspension. This phenomenon is illustrated in the following table. which shows in particular , that over 50% of the the treated animals survived the highest dose administered in aqueous suspension ,i.e. the LD 50 was not attained.
Acute oral LD 50 in the rat (Vegtable oil) 430 mg/kg 251 mg/kg 139 mg/kg Acute oral LD 50 in the rat (aqueous suspension) > 4000 mg/kg > 4000 mg/kg > 5000 mg/kg

Unlike other pyrethroids, DELTAMETHRIN is not a mixture of isomers : it consists exclusively of one pure isomer : the d- cis isomer.

Product Permethrin Cypermethrin Deltamethrin

PRINCIPAL CURRENTLY AVAILABLE PYRETHROIDS The following table shows the number of chemically possible isomers for the principal pyrethroids in use today, and also the number of isomers actually present in the commercially available products.
Number of possible isomers 4 4 8 8 Number of isomers in the commercial product 4 4 8 1 Number of isomers in the commercial product 2 1 2 1

The WHO has classified deltamethrin as a technical product that does not cause acute intoxication under normal conditions of use (Table 5 of Guidelines to the use of the WHO recommended classification of pesticides by hazard Document WHO/VBC/78.1 , 3rd revision, July 1982). The WHO classification takes into account not only the favourable LD 50 in aqueous suspension, but also the low dermal toxicity of the product. and its safety as demonstrated in practice. SAFETY butox is markedly safer than classical antiparasitic agents. Thus . whereas the therapeutic index of butox is 5.400 ( ratio of LD 50 in the common house fly). that of DDT is 11, butox offers a wide safety margin both for the user and for the animals treated.
LD 50 in the house fly (mg/g of insect) (topical application) 10 5 10 8 1.315 0.833 0.238 0.025 Acute oral LD 50 in the rate (mg/g) 113 300 129 80 415 430 251 139 Therapeutic index (rate LD 50 rate/ LD 50 fly) 11 60 13 10 342 516 1054 5400 Ticks Mange a) Routine b) Curative Lice

DOSAGE: butox is used in the following doses for the control of different ectoparasites:
Parasites to be treated UOKOHD u Quantity of butox needed for 1 litre of water U d 1 qJ W fuuO WOL Spray treatment dU WUFL qOG dI d WOMO WUF FK qLI 0.50 ml 0.60 ml 1.00 ml 0.25 ml 0.50 ml Plunge dip treatment fODGU WUFL Charging w_ ULF W 0.50 ml 0.60 ml 1.00 ml 0.25 ml 0.50 ml Topping up fDGL iuF 0.75 ml 0.90 ml 1.50 ml 0.375 ml 0.75 ml

Active ingredient Permethrin Fenvalerate Cypermethrin Deltamethrin (butox)

Product DDT Diazinon Propoxur Dichlorvos Fenvalerate Permethrin Cypermethrin Deltamethrin (butox)

* Only butox consists of one pure isomer, the most active isomer.

Flies and other insects d dA Uc

A HIGHLY EFFECTIVE ANTIPARASITIC AGENT butox has a wide spectrum of activity: it is effective against ticks having one or many hosts, the mites responsible for mange, lice, flies and other insects. butox is active against strains resistant to organophosphorus compounds. butox has a highly consistent action. A LONG-ACTING ANTIPARASITIC AGENT The duration of action is function of the natural level of infestation. Because DELTAMETHRIN is extremely lipophilic, treatment is unaffected by rain.

A SAFE ANTIPARASITIC AGENT butox is extremely safe, both for those who apply it and for animals treated with it. butox is equally safe for the consumer : the meat and milk obtained from treated animals may be consumed immediately There is no Withdrawal Period. A PRACTICAL ANTIPARASITIC AGENT butox - is very simple to use. - is stable under normal conditions for use. - is neither volatile nor corrosive.

* in oily solution (Reference pesticide manual, CRBA) TREATMENT SCHEDULE AND METHOD OF ADMINISTRATION The directions printed on the label of the butox bottle should be followed.
2300

MODE OF ACTION butox acts by contact (principal mode of action ) and by ingestion Deltamethrin is active at the following sites. nerve cell membrane synapse neurosecretory cells. BIOLOGICAL ACTIVITY of butox It is interesting to compare the biological activity of DELTAMETHRIN , the active ingredient of butox with that of other currently available insecticides. The table summarises the relative activity of insecticides sprayed directly on Musca domestica.
60

160

WITHDRAWAL TIME: In the absence of local regulations, the milk and meat obtained from animals treated with butox may be consumed immediately (NO waiting period). PRECAUTIONS: Do not eat, drink or smoke during treatment. Wash the hands thoroughly once treatment is completed. In the event of contact with the solution, wash with soap and cold water. Do not pour unused solution into rivers or ponds. Follow the directions on the label.

4
Propoxur

5-10
DDT

7 DDVP
Permethrin Ciper methrin Delta methrin (butox )