Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Coronary Arteries
Coronary Arteries
Only 0.1 mm of the endocardial surface of the heart can get its supply of nutrients directly from the blood inside the chambers of the heart.
4
Coronary Arteries
The Right & the Left Coronary arteries arise at the root of the Aorta, from the two Aortic sinuses just above the Aortic valve.
Coronary Arteries
The Left Coronary artery supplies the anterior and left lateral portions of the heart
Coronary Arteries
The Right Coronary artery supplies: Most of the Right Ventricle as well as Most of the posterior part of the Left Ventricle.
7
Cardiac Veins
Most of the Coronary venous blood from the Left Ventricle returns to the Right Atrium by way of the Coronary sinus (about 75 % of the total venous return)
Cardiac Veins
The remaining 25 % 30 % of the blood returns through two different pathways;
Cardiac Veins
Most of the coronary venous blood from the right ventricle returns by the small Anterior Cardiac veins directly to the Right Atrium.
10
Cardiac Veins
The rest returns directly to the various chambers of the heart through the various small Thebesian veins.
11
12
13
14
Intramural vessels
15
17
19
20
22
24
25
26
27
28
29
30
31
Collateral Circulation
In the normal heart, there are communications between the smaller branches of the Coronaries.
32
Collateral Circulation
When sudden occlusion occurs in one of the larger Coronary arteries, the small anastomoses dilate and compensate for the loss of blood supply.
33
Collateral Circulation
If the ischemic area is small enough, these collaterals may suffice. In moderately larger ischemic areas, the diameter of the collaterals open up further in a span of 8 24 hours.
34
Collateral Circulation
In larger ischemic areas or where the collaterals do not or cannot compensate the loss, there is death of the myocardium Myocardial infarction.
35
Myocardial Infarction
The local vessels supplying the ischemic area get disgorged despite lack of blood. Soon the area has seepage of stagnant blood from the collaterals.
36
Myocardial Infarction
The ischemic myocardium sucks up the last of the O2 present in this stagnant pool and the hemoglobin gets totally reduced. This imparts a bluish brown hue to the infarcted myocardium.
37
Myocardial Infarction
Finally the disgorged vessels become very leaky and result in tissue edema. The cardiac muscle cell begins to swell because of diminished cellular metabolism Within a few hours of almost no blood supply, the cardiac muscle cells die.
38
Myocardial Infarction
Normal resting cardiac muscle is supplied 8 ml of O2 / 100 gms of muscle / min. For survival, the myocardial cell needs just 1.3 ml of O2 / 100 gms of muscle / min. (15 30 % of the normal resting supply)
39
Myocardial Infarction
The subendocardial surface has extra difficulty in getting its normal share of blood supply. The subendocardial surface is the first to undergo infarction. The damage then spreads outward towards the epicardium.
40
41
Systolic Stretch
When the normal portion contracts, the ischemic portion is forced outwards.
This may result in insufficient blood supply to the peripheral tissues Coronary / Cardiogenic Shock.
42
Pulmonary Edema
Inadequate pumping of the heart results in: Increase in the Right and Left Atrial pressures Increase in capillary pressure in the lungs Cardiac output Kidney failure blood volume congestion in the lungs.
43
Rapid depletion of intracellular K+ ions. Ischemic part can generate abnormal impulses (Current of Injury). Powerful Sympathetic stimulation. Cardiac muscle weakness resulting in dilatation of the heart Circus movement.
44
Circus Movement
45
46
47
48
Angina Pectoris
Progressive constriction of the coronaries can result in Cardiac pain (Angina Pectoris) whenever the load on the heart becomes too great. There is retro-sternal pain which is described as constricting, pressing or hot.
50
Angina Pectoris
It often radiates to the tip of the left shoulder, left arm or side of the face. This distribution of pain is due to the embryonic origin of the heart.
51
Angina Pectoris
Treatment: Rest Oxygen Vasodilator drugs (Nitroglycerine) Beta blocker (Propranolol) Surgical treatment (Aortic Coronary Bypass, Coronary angioplasty)
52