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Dr. ROXAS
6/18/09
Stress it is stimulus that entails any form response coming from the environment
(Internal/External)
Oxidative Stress O2 + RBC (hgb Fe) :O2 + Fe+2 ---> Fe+3 (ferric) (free
radicals) that damages the cell membrane.
Response of Stress:
a. Physical
1. Chemical Mediators (TNF alpha, INTERLEUKINS)
2. Viruses/bacteria/fungi/parasites
3. Diseases
4. Aging
b. Psychological
1. Feelings (Fear, happiness)
2. Thoughts
3. Spiritual
c. Environmental
1. Physical Agents (Chemicals, Radiation)
2. Temperature (Cold, heat)
3. Pollution
4. Microbes (Influenza A H1N1 2009)
a. Thermoreceptors
b. Mechanoreceptos
c. Nociceptors (Pain)
d. Afferent Nerves (sensory)
e. Optic nerve/Olfaction/Vestibulo-cochlear
Receptors (Immunologic)
BRAIN:
CORTEX
Effects Vasoconstriction:
1. Increase the peripheral resistance to flow
2. Increase blood pressure
3. Can damage Endothelial cell wall (pressure and flow changes
Phospholipase A2 release and Arachidonic acid activation clot
formation (some cases only, chronic)
4. Kidney (Afferent arteriole) decrease renal blood flow release of JG
cells’s RENNIN
Epinephrine also triggers the release of RENNIN
EFFECTS of ANGIOTENSIN 2:
1. AT 1 receptor (Angiotensin Receptor 1) :
a. VASOCONSTRICTION
b. Activation of the Vasopressin Release Pituitary (Thirst
Activation)
c. Activation of ADH in the Zona Glomerulosa (Adrenal Cortex)
d. AT 2 receptor VASODILATION
STEROIDS: CORTISOL
1. Acute Energy (catabolism)
2. Chronic Immuno-suppression by decreasing lymphocytic activity
HOW?
ARACHIDONIC ACID
1. Leukotrine Pathway Leukotrines (LTD1 – LTD4),Histamine Release
(Mast cells, Macrophages, Platelets)
Effects of Histamine:
a. Broncho-constriction: Binds to H1 Receptor
b. Vasodilation: Binds H1 Receptor
c. Hypersecretion Goblet cells : Alveoli mucus production
(obstruction)
d. Increases the production of HCl (parietal cell) H2 receptor
binding (Risk Ulcer)
2. Cyclooxigenase Pathway (COX)
a. COX 1
1.a. Thromboxane A2 (Platelet Aggregation/Potent
Vasoconstrictor)
2.a. Prostaglandins (PGE1 & PGE 2)
3.a. Prostacycline (Vasodilator, Vasodilation) smooth surface
b. COX2