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Cellular Bone Matrix

An Introduction to Osteocel Plus

OsteoCel Plus

Osteocel Plus bone graft supplies all of the necessary components for bone growth, promoting your return to daily activities.

For Additional Information


We are pleased that Osteocel Plus might be a viable option for you. Since medical care is tailored to fit individual needs, not all information presented here may apply to your treatment or its outcome. Seek the advice of your physician or other members of your healthcare team for specific information about your medical condition. To find out more, discuss with your physician the reasons he or she believes Osteocel Plus will be helpful in your particular case.

To order reprints, please contact your NuVasive Sales Consultant or Customer Service Representative today at: 7475 Lusk Blvd., San Diego, CA 92121 phone: 800-475-9131 fax: 800-475-9134

www.nuvasive.com

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2009. NuVasive, Inc. All rights reserved. , NuVasive, Creative Spine Technology, and Osteocel are federally registered trademarks of NuVasive, Inc. Covered under U.S. Patent Nos. 5,811,094 and 6,355,239. Other patent(s) pending.

An Introduction to Osteocel Plus

An Introduction to Osteocel Plus

An Introduction to Osteocel Plus

Your Surgeon Has Recommended Osteocel Plus

OSTEOCel PLUS ADVANTAGES

An Advanced Bone-GraftING Solution


Osteocel Plus is an advanced form of allograft bone graft, which differs from traditional allograft in that the native bone cells are preserved.

In preparation for your surgical procedure, your surgeon is planning for your individual case. One consideration is the need for a bone graft material to encourage new bone growth. Because of the unique properties of Osteocel Plus, your surgeon has identified this material as the best option for you. Surgical treatment of spine and orthopaedic conditions often requires the use of a bone graft material. Bone grafts promote growth of new bone for long-term stability. New bone grows and matures over a year or more, depending on the specific surgical procedure and the individual patient.

Osteocel Plus supplies all of the necessary components for bone growth, promoting your return to daily activities. Osteocel Plus was developed to mimic the patients own bone by providing all of the necessary bone-growing components:

Due to strict attention to FDA and American Association of Tissue Banks standards, recorded allograft-related infection rates have been much lower than those associated with the surgical procedures themselves.1,2 Over 1.5 million allografts are now implanted annually, with no recorded disease transmission since 2002 and no recorded HIV transmission in over 20 years.3 Because Osteocel Plus contains living cells, specific processing techniques have been developed to support acceptance and incorporation of the graft by your body: Tissue donors are thoroughly screened and tested to meet or exceed safety standards mandated by the FDA and the American Association of Tissue Banks. Tissue is carefully cleaned and specifically processed to deplete components that could be rejected by your body and retain only elements to support bone growth. Each and every lot of Osteocel Plus is meticulously tested, not only for safety, but also to confirm the presence of active cells for forming new bone.

Cells Osteocel Plus contains living bone cells, including mesenchymal stem cells. These bone cells are naturally present in our bodies and are essential for bone tissue formation and healing. Osteocel Plus retains mesenchymal stem cells from adult tissue donors, avoiding the concerns associated with embryonic cells.

Disadvantages of traditional bone grafting


The standard against which all bone grafts are measured is autograft, which is the patients own bone. Autograft contains all of the components for natural bone healing, including living cells. However, because a second incision is typically necessary to harvest enough bone, some potential drawbacks exist: Longer surgical procedure Harvest-site infection Increased recovery time Long-term pain

Signals Mesenchymal stem cells and other elements of Osteocel Plus are able to send signals to the bodys own cells to involve them in bone formation.

Additionally, not all patients are good candidates for autograft harvesting, due to inadequate bone quantity or quality. For these reasons, alternatives such as allograft, bone graft from a tissue donor, are often used instead. However, conventional allograft lacks living cells and thus does not contain all of the components necessary for bone growth. Scaffold Osteocel Plus also provides a scaffold, or support structure, for new bone to grow on and through.

Osteocel grafts have been used safely since 2005 as an advanced solution for restoring quality of life to over 20,000 patients. To find out more, discuss with your physician the reasons he or she believes Osteocel Plus will be helpful in your particular case.

Osteocel Plus provides a complete bone graft, since it contains all of the necessary components for bone growth: cells, signals, and scaffold. Front cover: Osteocel Plus provides a complete bone graft, since it contains all of the necessary components for bone growth: cells, signals, and scaffold. Patients can now be treated with an advanced bone graft and avoid the limitations of traditional bone graft alternatives.
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Am J Sports Med December 2007 35:2148-2158 (allograft-related infection rate: 0.0004%) NHSN Report, 2008 (spine-surgery related infection rate: 1.57%) AATB. www.aatb.org

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