HISTORY of ACUTE HEART FAILURE

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today are the same as those introduced in the 1970s

4000 BC 2000 BC

2000 BC 475 AD

1500 1900

1900 1970

1970 1990

1990 Present

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1. Ventura. J Card Fail 2005;11:24752; 2. Katz. Circulation 2008;1:6371; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:3940; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499501

HISTORY of ACUTE HEART FAILURE

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today are the same as those introduced in the 1970s

4000 BC 2000 BC

2000 BC 475 AD

1500 1900

1900 1970

1970 1990

1990 Present

The use of diuretic therapy for reducing excess fluid in cases of heart failure, dates back to Ancient Egypt when a mixture of wormwood, elderberries and beer was drunk.

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1. Ventura. J Card Fail 2005;11:24752; 2. Katz. Circulation 2008;1:6371; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:3940; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499501

HISTORY of ACUTE HEART FAILURE

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today are the same as those introduced in the 1970s

4000 BC 2000 BC

2000 BC 475 AD

1500 1900

1900 1970

1970 1990

1990 Present

Ancient Greek physicians characterized the symptoms of heart failure including breathlessness and fluid build-up in the abdomen and around the body.

Click on the timeline for information

1. Ventura. J Card Fail 2005;11:24752; 2. Katz. Circulation 2008;1:6371; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:3940; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499501

HISTORY of ACUTE HEART FAILURE

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today are the same as those introduced in the 1970s

4000 BC 2000 BC

2000 BC 475 AD

1500 1900

1900 1970

1970 1990

1990 Present

William Witherings book in 1785 cited extracts of digitalis, a type of plant, for treating excess fluid build up in the body. Digitalis is the active ingredient in treatments used today such as Digoxin and Digitoxin.

Click on the timeline for information

1. Ventura. J Card Fail 2005;11:24752; 2. Katz. Circulation 2008;1:6371; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:3940; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499501

HISTORY of ACUTE HEART FAILURE

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today are the same as those introduced in the 1970s

4000 BC 2000 BC

2000 BC 475 AD

1500 1900

1900 1970

1970 1990

1990 Present

Click on the timeline for information

The first half of the 20th Century saw the widespread use of diuretics. By 1967, loop diuretics, which block channels in the kidney and vasodilators, which relax blood vessels, were introduced as treatments for the symptoms of heart failure. Both of which are still used today.

1. Ventura. J Card Fail 2005;11:24752; 2. Katz. Circulation 2008;1:6371; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:3940; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499501

HISTORY of ACUTE HEART FAILURE

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today are the same as those introduced in the 1970s

4000 BC 2000 BC

2000 BC 475 AD

1500 1900

1900 1970

1970 1990

1990 Present

IV

Click on the timeline for information

During the 1970s and 1980s, intravenous nitrates and inotropes were approved for patients with AHF. These drugs assist patients by relaxing blood vessels and increasing the number of contractions in the heart, respectively. Nitrates are still used to treat acute heart failure today.

1. Ventura. J Card Fail 2005;11:24752; 2. Katz. Circulation 2008;1:6371; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:3940; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499501

HISTORY of ACUTE HEART FAILURE

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today are the same as those introduced in the 1970s

4000 BC 2000 BC

2000 BC 475 AD

1500 1900

1900 1970

1970 1990

1990 Present

Despite significant progress in treating patients with other heart conditions, patients with AHF havent benefited from a treatment breakthrough in 20 years. Commonly used medicines for AHF treat only the immediate signs and symptoms, such as fluid build up and shortness of breath. There is an urgent need for new treatments that have the potential to increase a patients life expectancy and protect vital organs against the life-threatening an information AHF episode. Click on the damage timelineof for

1. Ventura. J Card Fail 2005;11:24752; 2. Katz. Circulation 2008;1:6371; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:3940; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499501