Deba P Sarma, MD Omaha

ACANTHOLYTIC ACTINIC KERATOSIS

M 67, right forehead

Hyperkeratosis, acanthosis, suprabasal acantholysis

Atypical, pleomorphic keratinocytes along the base, acantholysis, dyskeratotic cells

Marked basal keratinocytic atypia, acantholysis, clefting

Basal keratinocyte atypia, acantholysis, clefts, dyskeratotic cells

Acantholytic actinic keratosis

Site: Any chronically sun-exposed skin (head and neck, forearms, dorsal hands). Often multiple lesions. Acantholytic dermatoses such as Dariers disease does not show basal keratinocyte dysplasia.