ica |Ahyearc child presens toa pelican wth ested fim mavrtat. Shes alsa nctdto have core fall features and steal ‘Strammaies Stes agnosod wh a ore conn ae etl na research sti). here eal Heverlee ake er erscme {xamnaen On pabelgleexaminaten oft specimen, ls noted hat ere are characte nui bods senna clas of Indra els. Theeneosen bade stain poste scam poten spor mnvncockamisty por ecabirg tn rece of he sie pay. te physician explains tote patents meter hat her caugher has @ lease resuing om be aberart aralla targeting of pets ‘ii fn folonng cerca steps is scr n patents with is cseas6? 2 Acminaaien of pepe at acazes oe trans og) 65 Faia of targtig pati fr endoeois to tenes . Phoschoniaton of mannose restues ate cis Gol 1. Phosphanyiston of mannan edie the trans Go E_Phosphnfton of ranma osu in ho ‘endoagmi recain F Syrineis of preteen rough endosaenie s @OAca ‘The coreet answer is C.28% chose this doaase i a yrrme i ub @ pstortsuralete phaschnta mannose resdues en arzyes deste fer Fatsumes wince Galatea Gen athe rans Galihas a phoned anne ecopr at specs enynasasysosona. ese fenposptay/atea ‘rajres ae sewed 9 secretary product fam he ole lama ag tine cial syncreredesensed sve, This lodsto te presence cf evaracta2 Incision bodesin be cloplaan of als whih ree est ef ssomal pets ‘acung on he comens of he eyoaasm, ‘Ai not corset 8% chose this. Gvon hale rbtom coe of peeponatanin (82 Cag apepldage targeted tthe tran Gof wail wo eetvey teat he ‘ning patton oF he dene cr woud inalie ote core! area of he serait Bs not comect 5% chose this Falurecftargeing proteins om endcctcls tothe Tac wad oad to peti of poring pans. ot packaging a arena bf rotaine arteaaee wn te cll Lol ease rvs fam presleme ageing rotons rhea wn cal Wiceomes Dis not correct 33% chose ths Ponphorylain of monnne residue pots, fic targets them te yest, takes pace on he cls Gol retihe tans Gl Eis noteorrect. 12% chose this Phosphrylscn of maces resins nots, ‘ac target tum tt yostnes takes cen be Gl appara Iedoes Ml ‘ako place nthe ordcpaemic ecm, F is noteotect. 14% chose ti. The sya of pons on ugh endolasme ‘etalum play rok inte patogeesis fal ‘Bottom Lins: Tal dssase afecs protan tagging provering presphoylen cTmanrere aia cls Gand neg wih Wscsonalsarage Resiced rimevorers 9 symptom, s @Ostuton contr of pons and iter Rote plane menbrne, ees, sector vice 2 Modis Naligonechardes om apricne ‘Ald oligsaechardes to seine and heoine resides, ‘iin of mamoneSphorplale space Iycoaal rte > tet the poten oe meme Ptr amb fo ee pons Sun ef sium in poten a of selected i on ples Vesclartfcking pte ‘COPE nttge, Calg ER COMI senate, RER cnr Chain anole > Teen pon ‘membrane endoonee irceeonmeited| tndeevo ell diene nce Cheoe) ised sc ‘ng deen ed {itn ofoamnosed Pipa bese pole ene ate coed ode te cll intent af being treed the ome) Resin ‘sare fii ates, ouded comes ected joint erent sl big aan eel sa naive, Ofen a in hood. AaTeor ote ol Ina fbi tee to ‘he sume) Rents in coon fail aes, ‘donde comes, etic Fea surement te ai plea lon a ‘ors Ofen ta in ilo|Aciyearse go was bom sthemein aural ates reugt thle cline cause of Jaues. Stes pl slinned shows mated er ‘momtaetarasbn, ae has ust) body ode Ths exer dagnocs or wi 2 dec Wrahysrebopern metab ‘hich tha alin is a cect horapoute asin fortis chi? © A Branched- OP & be Ee ronmen > Ham s @OAca |A30sear-cldman presente amargancy deparmert complain of storress of brea, dziness, nausea. nd vom. He lo says tat NsPearfeol ike tisjumping aut ef my etost"Twodaye ag, ba pasta aburirg heuso ae stopped to lp tha roskorsovacuat He ‘epars inaing » sqneart aut fske,butceclned cca zsetarc ane sane because he hed re smtome. Theor eps Fening vr atgved th dy pro prosoraion ar eayedin efor raat oo ay. phys examina pe eS, Ho pressure i 100160 mmHg, and resco rates Onin wi dep, casing restr, Te rest ie exainaon unremarkable wt te rca of bight oc vostisin bot othe byesand sal obo amar on his boa ‘Whats te mechanism of cin of thetic gent st rest in his pabonts symptoms? | Decreased sed oygencaming cane © estes ny nnn of honest © loner ef cblularespietin . Rosen non Explanations s @OFiica ‘The corectanswar is. C. 60% chose thier a vox compen hat an be famed inte hightemperature combusten af mony ate an 23 Pebywrethan,acylonina, yen we ardent, hs making cyan posenirg Eenmen ne aefng of rake maleon Thermal carmen uae of ean ‘eisonng minded runt is oucohld res Cyanide modtasthn ron wn Stocker cease etacvams a8) the mtachanda, even abel ieruging te elberenraneport chain an aling cal riraton. Tse whe gest onygen demand, such as eft, brat ander, ere mest slgnioany afte baausooyande proven axgan rom bir fo oyochrerooxdaso are Serving ate a elon acocporin he coi. On petal examin rena ‘tenes ar veins are or rex i to absont sun cage nacional, {re paris ere ase of iter amanda cn te beat. These fring ree resent wth carbon nero inane eer oman as acct wh eke [inlaen Tresinentedea iucton of ebernaganenia wa nie, en ‘annisraten of suifae ‘As not cont 32% chose this Caen mes class, odes tats, ‘ening ga predved em he incre combustion cf any caborconairg Imari. Conan cures elude smoke lation nes (apt, Suiarcble exhaust umes, ard ceoy vents charcoal ergas stoves. Carbon Imenenie ids to heme 280 tes ree aongly than cyan, eaiig ‘etuved oenegain sation ond decrases doce ciygerser)ngcxpachy, 36 ‘wll asipairg oxygen delivery at tetseee. The maja of patent eampan of eatace, czas, andnausea:prltged exposure resus m mpaed fink, Sspazpe, cana catlsians, ad death Wh pln i erbon mana poimieg ‘nay nove Erg edvencu lone, ae s2enin ipa) dona ave esl ot terse on her bea Tester i wih 100% oxigen, ber by rte cr ‘yough an endoracheal tube: mn severe cases ahyperbarc chamber maybe Used 1 is pot correct. 3 chose this. Sustncas such as anmenia chr caso ea nyo expeze aoves. Syracuse sates beat, severe Bost s @O‘Bis not correct 2 chose thi. Substanoes euch as ammonia chains cous ‘ioc nyo expered esos. Symptom ras shoazs of reat, svere East pein vonfg, and tamactysi, The col eympams ni paler or nt harcore type of peaning isnot correct 3 chose tia Sarin gos inoversily iss aottpesterase, resign a ead of acelin synapses. AS a esi, ie body frpereraes a parasympathetic vefood en ace! paral Simmons of san Pelsning depend on degree of axpsute aa hfe ethan ey resemble Sere ofthe symptoms i pater xpetendeg Howsver, te cieurstanes of hia in sotto an avers elec cf nbn ae oopoees to poaing wn 2 Naki warfere agent. Es notcorect. 1% chose this Rie oso eats arene results abo ‘abt roten eyes siping bacco oer pune ae sane of he Imes ceter cytosine inet ita igh ln metal abla to afet 1500 ‘eros. ntlson of ne coraonzed by 2 clay finial Teas or up to fours. elowedby fever, thy eyes, cough, congestion, chest phe, dyeprea and ‘ausea Fn s dared fem th sme fart produzae caso al and pozaeing bf ast arenes been aestisec win occupa! isos ‘Bottom Lins: ica [Gyan ates re ror wn cpocrare case us inevng wi he lecon Fanspor hah and celular reapretn hai and orate maicasprat on dyer poset se FAH, cle Uscon ransport_——NADH ecto fo gheais and he TCA cl ie aoshoni via ie @oOoecon transport ‘ha a orate ica [NADH elec fim gba the TCA eee ese itochondi vi the hateaspatste or yor pephate shite FADH, elect ae taser to Phosphoration Completa ker ent fe than NADH), The psig lactones lero proton gent tt coupled ous espn ton dee ‘he product of ATP ATP predced vis ‘MIPvuibee: | UNADH= 3.1P,1 F4DH, + 277 Oxiaivephosphorsation pions lastattanspt Ditty abit econ tampon, using L inhi ton guaeitand Bk of ATP thos ATPaeinuton Diet tbl steer ATP casing ‘0 Tprtngaent NoATP i pode ‘cae lect spe stop ‘Uncouplng aunts Tpemestiiy ofenbrane, crs 1 proton (faded TO, consumption ATP Sot tp, at econ apt odes est Roteone, Nanni, ‘©. Oem LADNP, pines ater ‘ecurae pain ede, (ermogenin it bern s @OUncouplng agents 1) ‘esa econ mip tp, pererhiyofmenbnee, cing Upton Povketand TOs consumption, AUP “hs tps bit secon rant ois, Prados ht Speclc antidotes Taxin 1 2 5 4 i ‘ Aestannopben Sate Aphtanins bse) Auicelieteee, gmp Aime atichie ant [Bicker Dist 8. hoe Tent Maca, seni gold Corp amen, gd ‘oymnide Matnebin Caen monde atl tiglne so antiteeze) ica DADNP, pin Feve fen seca iin ord ‘hermogeninin hewn Antidtietinent ‘Naceteteine NalICO, laine wine), ats NH{CI acu) Alpine, prldxime Phowmigmine teyete hers Stop da noize KS [Beane aii Fab GHEDTA dine, sci penne Dimes BAL Penelaine ite Beeson, thie Medien Uti Wu 0, pete, ona is file a me)Aphataines hai) Amholinedetese, ozmophorpates tino, atic ge Bilder Digtale Macy, sen gold Copper anemic, ld Comide Mathenodbin Caen occa tana, eile shea ntcse) Opiate Benzodiazepines Tek Hepa Warn PA sueplciane ‘Theophline ica opine, praioxine Plosnigmie sine Chore Stop dg normalize KY, Tenn ati Fab fgets, Mg Daernamine (CHET dimercepel, sce, eniclaine Dime BAL Penelaine [Nis eens, ‘inte Methyone be, itanin W070, ppc: ‘hana das omepizle Naloenconlecone Flue NAC, (um albanien Protamine iain Kesh ren past ‘ninecpmieaid Pocee s @OAca |A22.yearol woman presents ar faly physician because of iceasng fatgueandbecause se locks pale" despite spending many hers tude asa camp casolr Si ale slate at her ume ok “cele sa rl gosto te bar teaming Tho pao, feels wellatanise. Bood analyss stows ow lates cut, ow RBC cur. and lou WEC cout. The patent's ECs are mixed wih ‘ct ral snim ard cared a ronal RBCs a xm emperstire anda 37°C (Fy, oth iemperatres cae to pao, Bunt thera RICE oe Beso on is lial plete andthe aberatary tess, span mst hay has which ofthe folonng sere? (© A Alkan © 8 oystauta © © Hemaphiia A © 0 Maplesyup ute dscase (© E Parowyanat mcumal hemoglobin os s @Oa The corect answers E. 810 chose this Parccysmal necumal hemogltinuta [PMH] eaueed by a defect neymbess ofthe call anchor usd ona! race frotsistotiecllmembranes of RECe WECs, and sles Tees leads bre inical manfacare oft disorder. anemia caved by ntavosrr Ferns ang terogichuta and he deerec ui) rembosesnunsual ens, nd fomalepsebe coenens acing taparcytpan Thabemngeeocirealdy, bt the conenated ume ome ovemigt shows an anes car cargo. The Ham est [ring he patorte RECE wacked sorum fused fo dagreea PRN Lysis oF fo ators RBCs inicates PN ‘Ais not corse. 17% chose this. Akapinutaprosnis wih ip thot dations aor frpuntetearas 8 reat of kapon bodes (ecsumulton of honegertii a), ‘eal as carkeing of cmos fssie Paonte may alsa have ata Bs not correct. chose this Oystinyis a dueta a det in he ular amin aks aneprer nse bnys Peta can fom eyine cn sans to igoee ete teu Cis not comect. 1% chose hisHemephlia Asan Yulked dase characerzee [octal sovrs cefione) by spontaneous losing, easy burg lest ses, an ramarovous ito wobfaenng an fp. hr, ané ar) Dis not corroct. 3% chose ths Moo syrup uno soa is casa bya dofcioncy fehatosald dehytogerase Patents reer leur, seb, faluete the, mortal retaresten and urna tat srl ko mle. oom Line: er Pisa derdor of honsioponic lncion caused bya ceacin fa eynhos of GP ajeannhaandyinsnia) anchor [ctaractrzad by hravescl heros, paieyooeis, and vera hvonones in atypical es otine Wi AaGARD avicleney Prt kine ceney sie call ens ica Deep nrg ih RBC oe lan penne icesmbyncbnd Seco ‘rape ex mente ener sl nd oud RBC ih no cen pl {TSICHE: TDW panne eal RECS pn. anyone pte ae wt Hoel ih be res ae “nose Lae te coma agin iia Dectn APD ~ {dts TRAC smc oon tes Feng: ows enfield, too ens 1.80 Wl near sh RBC wh Hes ie elle ‘tomatoe, Dentin pnt nan “> ATP 9 HG RBC Frees hac seni nests So Aan mtn aye HES es. hn te dee Select cence RBC Cen et" onc ma xeon fm ethos an ‘hier Newbury soni ong tT HOF and LS. ‘Mun wala ne open Pichia bon mags wt) tens de BS pletbs Lae Oo deat eit “et acetic it ne eine Compton hana cl em Tape cs de pains Bin) 2 Aatlcectny> fe neon wth cnepae onpine 2 Sumit rolPrt kine ceney sie call ens MC det Parma octal Tenaga ica a a ens 1.80 Wl near sh RBC wh Hes ie elle ‘tomatoe, Dentin pnt nan “> ATP 9 HG RBC Frees hac seni nests So Aan mtn aye HES es. hn te dee Select cence RBC Cen et" onc ma xeon fm ethos an ‘hier Newbury soni ong tT HOF and LS. ‘Mun wala ne open Pichia bon mags wt) tens de BS pletbs Lae Oo deat eit “et acetic it ne eine Compton hana cl em Tape cs de pains Bin) 2 Aatlcectny> fe neon wth cnepae onpine 2 Sumit areal 4. Pattern amccene) 3 Renan neces O in pile 6. Spent eqetion cbs nage) “eer doy BF) an oe ma tpn. ‘Sct Bain ton puns al NC SE Oe chat ee ve lor den than dh pen Pings nmi home dts complemented RBCs ‘imstedsntesn of GP anchoring urn RBC wens) Lie Tanne best, s @OAca ‘A yaeroi boy a reugit his amy hyscln by his ater because ae cerca abot is "ace waking” Physical evarinston revels ‘tara rusia spasm, ad Foros. To paolo hae ait of gonad eae ae sexing a doereasng abit oop Up mn enol Famiyheay incase pislre on moter ae ce fry sce Spy srave sargerizes ard ieguar mule fre Ho iste eco inert? (© A Autssaldoiaat (© 8 Autosanalaseaive © 6 rachael hertones (© 0 Sematc mutation OE Kine rcessve os s @OAca The corect answer is C 49% choo ths: This patent i prosontng wit myosenc eplepsy ragged ed fhe (MER) a rifachntely vans disease In ‘ioc nentnce al chen (ria and fom) ofan afer mahor may {ni te lsase. The ay foun he caret awe fos gust tfsrrg ote mother ar aflected. Th disease snot raneritied fom faters ni Ina Yenmssn ocr MER is cto a pat mutant be milocnenaal prone Patorts exhib rucce spans, myopathy, alana, gnerazcd soir, Imatesuol deteorain, and eating ese MERRE Uva presents chon or oy adtoos| ‘As not corset 9% chose hi Atsconeldominat haranas shows elscoseln ray governs th batt mals and females fetes Bot maos and females ay rans te deecive gone oe feng Is a ben soso dint Innetaca, he ofspng of maternal uncos wu alsa show evidence of sease ‘Atcoomeldominat iscrers nase myotonic dystephy, which characte by Iyoteia, muscle wastng, feria beng, cetaracs, end ancpstoninsubeecuet erations Bs not correct. 7 chose thin autseral rsesehe actane, «detec one from each carr parents tanemt tobe offspring i causa oxproston of Fa "Matos and femal are equal hal tobe alee, are genertans of csea86 Sar irtorspereed bebe sfferod rifuns Ine ce bth neon ae chi 6 iaang disease symptoms Dis not correct. 1% chose this Somatic accrn he sat sng) ‘ses thy are ol vanamited in sig an en occur inns dials ina amy Wales and fabs are oqullysscopble to sora mitatons Es not eottect. 34% chose thi. X inked cose hese shows affected nal Indhcualsinherang a detective copy of he X chromosome fer hetor=yecus (asymptomatic) mots. Thetels no maleto-malevansnisakn Ouchenr 3 muscular Cheep le Xsnked recess, end characorasbypogresie muscle wasknese resetting in chidaod asaced win Cowes maneuver an call‘reseringinchithood asccted wih Gowers! manmuver and al sudarypencay ica [Sispecttachonatinvarianceln diseases passed cxhivelyBvaagh Haid mata (ey MERE) Modes ot inheritance Aaoma omiant ten eto defects in stra genes Many ecto, bth ean ae, ode 15% of fiping mn Laie ped ae afl. (en dc renee defitenser Un en in (Ofer peop ann may a, peat che fe suber Fa ise ral te dagios Commonly resent than ‘dinar odor patients ‘on pret in chlo s @OSiosofhetaygous motes havea 57% ance of Taingafetl No naletoadetinasion inked dominant Tinsel ugh both pace Fler malar fem ofpemg the sci other a bated wt al nating the Mt tor ae deed “Tian ony though ther A psig of feted females ny show sig of dee ica Common wore sexete a ‘mls Htso2gn els tiny bealfetal Mepopbonpatenic che ‘ome ee ar Dereshant kts Inet Ahonder wang T Phophat ast pron fue, Rea ico Vorb agteion ‘platen dete Leber beet optic searopalhy = depeneion of ‘inal emgion sella ‘one Least ute eto ‘also,|Awaman of reprduave age hs has rheumatoid ats stars aking metctesate, an arietabelteapet, because cffuther rogression of ror deeace Sosed on maltese’: mechanism of acon which fh flowing cal pes is mast aly tobe adver alate? O A Hepatceves © 8 testinal muccal els © GNeuens 0 0 overs O Recs (Esenato er A @oOoAca ‘The coreet answer is 60% chose this Mathonoxate 8 fale ac! onlay tat binds to ane neces dhyrtlate edurtase, ereby nig pune syns. As ‘re, cals are suscep o mthresse ding he phase cf be cal cyte “hart, cls at have shart i phase etd protec reply othe Space wl be met aiszalble Oe cls std, muzzle of he Mester the els et Uncergo te met repean an il threes bathe most secs by mathe ‘Ais not coroct. 8% chose this. Atha mmtoteaato imation yh vor, eps dora ofan replae op.ly aroas pat of We vee rem., romping hepa regeneration. Thee ee case te vane provided, tortor (ental mos oa sv beter snawer Cis not comect 6% chose ths Nevers repeats exemety only an weuld havea lang Gt pso. Three toy wi bo oss avers afforted an inssal masa calc repeat quck Dis not corroct. 6% chose this.Ooey9 of ho alt woman do ot ndergo mie ‘Therefore ooeyes waukibe unfece by metoexate, whichis ding he S oreo calc isnot correct 20% chose this Ca da at die, which means they have no fate ane wl ote secs by metrenat ‘Bottom Lins: atcevai sa le ac avaog a in pute sed, ening ih tony to cae Watopleae cayrae Myclnaprenion hich ecaeed levcoonin ine eid) see” eee hang ie ‘cot ergo rindi slog ‘onto SEAUMP, wich corey complnes eee “Tiscomples nie Upmidlateyatiane lat LDN, sr Lp ati Measiprsion which ‘not reerbl ith eae eee ‘bymine Potent Paros (hi) aloe eee al Ther Meablsnd Ip sahine oxide: ths osiay with lepine ‘ihcaonine TG) ‘Bone mano depen, a me)‘thcannine 61)|AS0searaldman'e clagresacwin ype fama cjloisemiaRecertlaberstny stds show an elvete igen eval but ronal LDL and OL ctoestor lve ‘hich fh along explains te patcphsiogy of hisclsease? © A ApaipeprotinE aelorcy (© © LDL enlastee rcepterceflancy © C.Upereeinliosse defeleney © D.VipL etolsira clearance cecleney (© E-vintetaesteseveeoduon (Esenato er A @oOoAca ‘The corect answer fs 6.61% chose ti Type dystpenia(a onl poeta lipase defsorey}ls caused by a decency of pepe pase. Ts orzsr xs Imeapiany wall of adpese and muse sue and cleaves thats a ee ty {es and hero, The erzyt Is actvateaby apopepean Cl wich found co ‘VLDL eter snd ehyanirans. Type dsm characterized by sn ‘ccumulaten of ighcete-ich popes inte plasma, Defer In apelpoprten Col produses a sino rest ‘Als ntcorect. 15% choss this. VLDL chleterslrrmars se enced fe he Crelaony apalpopreten Ese Th, apolipoprotein €deceney (cjsoetlpcprotanams)resutsin an sleated VLU chattel gon, a {nostra nels Olen is dscrder manfests wih alr coon fal aise ‘ypersdem such asclabetos Xerdemae ae often present iis not correct. 10% chose hisL.DL choos recap dyson ie ‘horasetate of ania Nypebetaipopetsineia, ase kan 23 ype yperindem intse caso, plasma LDL ctstero aves is, ich auras an Inereaae in plata cestr genre eel remain naa. Dis not conect 9% chose this ved hyperighcecema (ype Visa \jslindoma characerzedby exten high Welyondo fol and vil eary plasma, Unies pe Vf charactergedby seveed VLDL ener aves Sandie ght be ote VLDL caesar learn roam Es noteotect i chose thi. VLDL. chitstarel oveproducton is anaer Characters of V dlgdemaa, a3 wel es ps lo cmtnes hypen cera, ‘Bottom Lin: Fjpe1 Tara jsp iste rsikofipaved Wacyghenol degradsicn duo a deicleey of eer Ipoprata pace cr palpepraia ch s @OLipoprotein anctions ry Lpoprtin te compan af aig reparins cf cholerae (TOs), the phomlipie LDL. and IDI cam met cho LDLitmpaiecholstol fn bere tious. EDLit Ln. [HDI nop tom psp ne TDL ea untion and route Avatpapmtins Devers detry TCs pepe ue BAS ANCHE ‘Dave cholera ier nthe fom clylamicron remnants hich re morly ‘kptd of steel Seca by ‘nk pel eels Deters heatc To pepo ane 100,64 na Sette by Het. ormed inthe deedion VLDL Delnere Bland ighcrds a baat hen they sre dened LD Detiversheptc choles topper es med by poproinipae modioation of VLDL inthe peripheral sae Taken yp by tet celleiaeceportnedated endoeone adits see cele tanpot fo arg oer At aa ropa fo poC and apo (obich re needed fon loloniton od VEDL metal Seccted fon bth rand intr. s erica ripe oer, At aa repo fo poC and apo (obich re needed fon loloniton od VEDL metal Seccted fon bth rand intr. Fail dsipdemis Heated tye Bo esels Pathophysiology TIypentplomicrnenss TGelelotesl Lipepri ane deciey ‘raleedsplpptein CA Gamer parent, ‘epneplenonweny, nd pte tonas lo Ts or atherslro). Hs tasia Atom onan set Tepercholeerlis TLDL-rceton Cates scdlted sows (ead Achilles rations, acre soe epic weprtcion ef VLDL, ‘Canes pert eta tlt tye pepe deo dicen in pe 10 scape BAS “mrad ete Spins appar ne torment es, tet Bop sho acumnltion win etc ew ably espa ips Solomons iad teeters sco ta gt don, s @OFiica ‘Anew smalbmatcule dug fete weabrent of HV has ust been discovered This sal olcula apperst id te a reuly Gecupodsutece prot recoper, TTY2, ne ot oa cascaring sal at oad oapepoas oft col Tha TTYZrcopor i express ost havo boon Inet by HV but no npressodin-rennfeted cel. Using invive exponents, scioistshave bean alto show hat bang ofthe TN ‘rene lads to anincreaeemnaclr ahi ‘The TTV2 recap is sia fo which of ha falling empl? ae O80 ocr Opp O E Dopamine; (Esenato s @OAca ‘The corect mswor is A. 69% chose this.hon acted tha Gy case of S- ‘iupled pote recspas rate inacalon of protein nase C and an tena in ineacoblr calcium Ths, ke to TTY2 rooney, ho a-adrenongc recap is (iyiaes Coupled pron rceer Ofer Ceca recep nude muscaie, scares, ae histamine Bs not corect 8 chose thi The o2odrensgicvecop sa icless C-xusled frotinreceptar When achate, na Gretna toa detest nyse ‘nkzrosne Morophasp and a subsequent detease in prsain Khas A. Ober Gs Claes receptors nt museannic2 ana dopamine cepa. Cis not correct 17% chose this-Tafi-ackornpirecapor ea Gr-clase feupled etait rena The Gs ecxplracvtes aden cya hich cavers [MTP cei atorcsine neophcspateandeadsto ta achetin of proton kinase ‘ROter Geos ecoptay clude #2. dopamine, sndhistarane? Dis not coset 5% chose thse f2-acreergercerterisa Gs-less G-xuled rotor Th Ge enor asso aden cel, wich eaves ATP to {ele adrosine merophaphat ad lect te acta of pce nse A, E isnot correct. 6% choss this. Tho dopamine srroricrecapioris a Ge-caes feupled pts ramp The Ge recsplr aclales aden cyan, wah ents [MTP o cei atorcsine meraphusphao and eae ita achvatin of proton kas Bottom Line (Gy auas ceptors ncuae mscoiney, muscarne® and isarinstGq-Gasseaapios scale pooopalpane ©, causing aa avene rests weneptate (ohicn lacs caleum laos ine cal) and layers, when eadso pete nase C acvaten, s @O‘An Byearolt boys reghto his pedir fra schoo physi. Hs paren rap hte isin goodheath, They ave cncemed,howover, tocateecorascraly ty frida roan una ne fet ate he fon forges fush Unnaljees rderec ho hs ume nay appear roxal suum care air tania. ‘hich oft olonng enzymes is defsctvein ts cls? (© A Branched hain aetna dehydrogenase © 8 Hemogenisle act tase © 6. Phanyblaninehydaelose © 0 Pane acts nase (© E Thrasnese os a er A @oOoFiica 75% chose this.Thispatort srs ram fo aioe ‘eons daeer aera, dfeeney mhomogarise aed tase Ths ney is oeponbi for ogradaien fires. Ae aoc hs decoy, eros Sn accurlaln of akaplon botles (agente ac) nutes cartiage The ack bf aragoréac oxidase Boks ha etabcem of proryiinno-yesne at ha vel of femnagetse ac The hamogentele ec aecumdlates od alge ara a ‘acrotc pari 3 ac eno ni alowed a stand and ander osiaon Dark spol ear abe ctaened nthe eyes of cma patr Aflac patria ste ‘ily appara in chichood ote ante change nue clo pon standing Inatuttons the but of lent in carlge and scales can cause ae ‘hargosByar unknown mchanisn th part causoe te cariage oes realty at becca bite and baoed Me ertuapahy dew only ad ‘ily doer not aries uh pat eS yar old. Alban et Swoatning, may be severly sabre ‘Als ntcorect. 10% chose ths.Adeclecyof branched-chain aktoacé \ohycroganase wat resin maple sp uw cscs, an ably obreak wn tranched-nein mio acs Cis not corroct. 7% chose thisPhny/tolorura is cause by a deconcyin Penilanne neroniase, Dis not corract. 2% chose ths Refsurs seas ea cefelaey of shytaic ace ‘idee aris characoreed yan natty lo baak down ranches cha ay ck E is noteotect. Ye ehose this Triage sth anya reponse one synthase yen. Tis dtoency resus in alanism because peters are unable 2 dale of rosieica [defaoncy have depcetin of fanegenise ack cartiage an heart valve and fle od jan and vale rplacemen, Haragersie ace! ‘nouns tums Sec un strana ST AID ‘Ahaptomaia Congenital diene fhomogentii aid nis inthe dete pty of (ochronoss) one Atoms ceive Regn dese. Find: di contectve tne, pigenled ses, wine rs Macken std, ‘Mayas debiatng alse Maple sypurine lok dagption ofbranched amino ais eens {eke Val dct Loreto debdogense Case Teta in he lod special Lan (Caos sree CNS decree etadaon and ea Conga dfciene ef either be floning: Tree Gina to sytsize wen Ii nosie)—asiownadrsevive 2. Defense amportn (Lameunt of one and hae en) Can emia ack of ign of su crest, Urine mel ke maple sp. ane Venn male frm np teeth ‘ral Lack of mann sin an kof cance ‘able ier dct Toots terogent (cco albinion~ lnk rosie. @oOoA Sosearcldman grsers to line forts frst ta Hehas ret een a dockerin yee url few merns ap, when te prsariag one forgery dopant ah 9 saver fiatache He urenwor losing bran siren ade om wart ao Deer car fhe hat: On {raminao, yu roles neha eb sana cele: ir, ae walla abundance of brass al ver hebody When eee, be 20 thos fhngs-tnin he fami a ave never sed any probi Hi metic his x ihrie unremarkable ‘What det is mcetkelycrtatng otis patent's desaee process? © A Type catapen © 8.7ype calgon © 6.76 tt catagen 2 DHyaine © E Fein (Esenato A @oOoThe corect amewor is C.4Z% chose hs This ran ily hs Elan sytome (EDS) a dsease of ely colagensyesis ost on caused by deecve ‘yp I calagen. Pants wih EDS havo yporexteneto sk, hypor@bio fants, an hay lading mandated by excessive bring, Hala maybe abocted wot Gilocaten gan np, or boyy aneurysm ich ha ie a his a, ‘eesatating emergency reusnugery. EDS can exist sucsomel dont or ‘eens infarc, an nial avery can vary greatly Typ Il cage (retain) mokas yp thes deed vessel, wists fet ase, ard gnu tue ‘Alls nt correct. 12% chose tls. Tc IV ealagen makes vs the basement ‘mombrao of hoy eas and eyos Roos rat ext fo palo of E05 Alps srarme an Kank recessive cra resus om ceecbe pe Eagan: Cine! manestaane of pars ede neocon auary subareas alg with ephs Bis not correct. chose this.Tpe calla makoe up cals, th rere ey and emacs pont, hl generally doa ot ate oe pabalgy ef es Dis not correct 7 chose tia yal ison of he aia prise compares af ype lealagen atte up caiage ard oer seucures AS discussed. pel cellagan defect tenth oa anne cause of EDS Els noteorrect. 319% chose ths Fini responsiio frie cress nrg oat fn dtc fein ihe case of Martane syne, Pabortsth Mota: Sypctee ae general tlw ng exremies and aracinedacyy. The fein ‘aon neo 9 nereazodprevalone of ste ae al vale nempetenca in terse Marans snea, ‘Bottom Lin: EDS isa disorder of alagan srteasleacng io hyprerenabl sr, hypermoblejants, and Ineased Weeding Twervostconmen eooay of EDS is efetno yp I elon s @O‘Men sbdat pon ithe ha by [Be So Totalh) Cool, Read enim ‘oak: Oana sentence ata ‘Type 90%} —Bone, Sui, Teo, det, ‘Type BONE. Tc comea Inte wound epic “TyellCarge nlons Waie,sitous Type WOhae ody alan gulp “Type Metoin}si, Boo recs ots, alto, ganlaton tinue ‘ype Underthe Hoor Teen nenbuae) Fay coltgen sis ens ‘Type collagen ino 1. Thpeetes les gue sect 2 Tendeney teed (ey bsg) 3. Tapenade jets ‘ype Ineitace and ee Can be ‘tonal dominator reat, Me be ected na jt slr seaman apm hee Seely poten wis lang ge tein, asic "gamete cod igen ars comet serebe > ei aid athe contain). [Rech in pce and ghenenongyesltd fens “opoctsin ah easel Maris syndome caine a me)Teco ne wd epic ‘Typell Cage clad aie), vous Tipe eT WOlage ody mel pelo ‘Type etc), Hood rues tr, eases, gorlition ne ‘Tye IV—Baemestembnne or bul amina. Type Under oe Tenet mean) Fly cltgen yess suing Tipe cllagen sno 1 Thpeestensble sin suey ace 2 Tendeney tote oy bruising) 5 peace fae ‘nypes nhetince and eey vay Can be "loon denn oe see, My be ‘ined nh ji lcm, bey seus, an ryt Tignes, voea crt inet a connect ‘elelae— lied andthe conan) Rech iaprclieand ghcine, nxt fra ‘rpoctsin sth lin cling Man's androme—cnned ‘ren do by line, which sno Iya det in Buin. Inhibit by wats apna bcd (ntti deen resign exces clate-Anovel medicston hs ben dvelped at ibis bacterial grow by ager he same crganalo as ertromyci, ‘Wich fh alot eukanc cl wl be ma cera flected by te nw mada? OA Apoooicboces © 6 Cellwtin tha etm crraum © 6 Cote wih a nucousin kanye 0 0 Enveyive 2 E mytos ceo A @oOoEnjremycin frets pokanctc norco (SS), hich arsmiarte miler ants can also be affeced by realmrt wh tase agers [he mtacreataaytazes RNA ar NA, roteinsyathesis US inhibitor: “Bo AT 30, OCELL eh inhibitors, A Aminghcosdesonetomycin gentamicin, 850" ‘wage saci act T =Tetacelie lactose, 508 inhibioee {C= Chlorphnio, Cindy lactose) F-Fthionen lacoste) comic] abies sae s @OSUS inkibioee {C= Chlorphnio, Cindy lactose) F-Fthionen lacoste) Linear fcteratte] abies sae Init 505 poptenee atiy:Bactentate eins Elaemoplr inflata, Nein enn, Stepuccecepsumcis) Canserative we ing olin Anemia se pene) aplatc anemia dou independent ga baby dome in Pratt inn hci the ec er UDP tae) Aa“Temiotion Actoted by GTP bis nition ict el) Tapas he 48 hom bith Into RNA al at eed whe the mRNA sndthe coma satiate with th engl “KminensARNA bind Ate ect for instr eine) ‘ibn RNA “hy” ales epic bond aonb, ter going. pabpeptide amine sad a Aste 3. Rikers advances? moles mand ¥ end of RNA, moving ppt RNA Pate lesion) Gonphial pein selese fan nism ough ale Ids id soi, Taare 1S + 618 = 508 ten Paka 5S + 508-57 ‘048, ATP=IRNA Aton — GTP ANS Gaping and Goi lost), Thank of ng APE ‘ite =ncoingAnsncne} ma Pate ~ accom, ing Papi steels apy RNA ita ‘Many ano ae pin ‘ys aio Amines it Team of the nition comple and eae moteading of RNA Coram iis 38 peptone Mace: bind 80S, Mosking tection, inden ios 50, cing tadocston @oOoLpesygenatepthoay lis Lekarenes Lr Liposgenm nd Lit, es net chemotactic gem Teulon LETC, Dy and Ey fron nbronchosontricon, —Neophikanbe BA thn, ‘eancominction, concen ef cc nel, sad Tsar poreabi PGI inhale gaepiion nd promotes late Gatheing Iie soins ern 9 eens) =e) eaten 7 Fit AaZaman, Mn Moawponne Te ‘montelukast ‘- reapers ce re |e Sa eres (bn in tar ee Sty and nn Shed a pn torn aspirin ‘Mecano Increribly iit cckengense by coment bing which Jsythess fb Hhvmbosneand peta tinal we ov doe (700 mp) pet aepaton. Intense dave (300-2400 mg snipe manage igh dove 24S10W mis) anlar “esc (Gua ast Choise anna act eal falta neh ond per len Rees ame i ule with sa ition inland oleic acs icounaeste dependent ‘chidoniai iliac isbn sil ty[An efectos isasecincan sends a serum sample cine abratzy technician fo HV dlegesics. Te cn a postive erzymeinked Inmmurssatort assay osu te oencin peers a Wstom io, akeayirg ero proganco of anibodiaso too dere HW ets n Be ators sum. The mage shows the resus: Tbe sth colo postes, ube 2 Is the colo nopabves, and ube 3 ibe patent's Se ‘ih of ho along is tho st appropriate nox sep fer to cian? s @O(© A Bein is patent on AZT therapy O 8 Protetis patent's T cals (© 6. Repost Westem blot because of tamination © 0 Repeat westam let because of fale posine ret (© E Tre pation does nt hove HY s @oOo‘The coreet answer is. 18% chose thi. Erayreticke immuresorbant 2830) hes 4 hgh fase-postie rat. and tru rust ba conte oy Weer et. Te ‘Weslem itis Why spec tes la ery alae poe rata such ta esti reactn fro of thes commonly ested HIV angen nates disease Poalve sid ragave contol are crnanly ded inh sare batch to erste Dat he assay was access The mest porpi ext ie Is estas an pret for Ds patent by eblaning he CDA cunt ‘Als nt corect. 20% chose thi.Orce © CO4* cute setablehed an ial eae cola ptont stu! begin appematopephyaetic oaimet or exper Inecons such as Praurnceysts rover reurri, For anbrerovtal reat. 8 temowtonothipty ace aie erapy (alsa emu as HAART) he appropiet approach, net AZT renterap. Cis not corrct. 6 chose this. Tero reason oboe ential hae ecued Info, ihe postive crt anbodias wore mistacel aed ne Paton sample lane, ora weld expect at tare woul be toe bard resotin at Dis not comeet 42 chose this. Sch he postive and nagetveeorels werd wal, astivaobands are clearly prosorin te posi eal ae, and bans a ‘cent in negate cone ae Eis not orect. 8% chose this. Tha West otis confalay fo Hl ‘Bottom Lins: [a Westar tis pace for HV Wits reine asive of vee conrinlyisied HV arigans.Obtaing a ODWr cain Tapa assay Ihopatort's nok epparuniicrfoctens Swen s @ONor bt Westen at ADNA ample iccleenoporeed en ean thon ttf oiler Te rte ed iv ‘kata and sibel exposed oa ed DNA probe ta wegen anne ois complementary rnd The reins dbl ‘ted labled ice of DNA eve hen the iter espase to Sint eg cet ht Nore Biting ‘mle aductve DNA probe binding simple NA, Sle poten separated via gl eecooreis ‘dtu ta le Lala aids ‘el tid to ler protein, Avid imnsog technique teting for “neni ect Faents tnd spl pce wither 1 Tetanges emped oke genet cme) tose finns een 2. Tea oupad cao-geveaing cite) toni ean agen the tn stance pee nthe ne, the in wi ne nn cle ‘esti eng ae est eh SNA RP, Southim= DNA, [Noon RNA Warten Passi (se in ma orto to dstennte whether parc ato es, SEI poet ns atent ood seme. Boh he sensity and he ‘pest of ELISA approach 100%, but oh be pte snl beneptve es Soccw a me)[A year boy presents tothe pelican wth ever, fal tedemess, and a green, outselig nasal scharge. The patertsegresed wit Sinus andthe physican rats athe has aise ofrcurertepcode of arusis Xray oft cst dare bocaea of Tove ‘eves sume iste anh an ons te eet ssi ner Which ober fing well this patent be ost kayo have? © A Deteave ahd vanspart © 8 Elevated blood auger © 6 lterty © 0 Reactive airway daease © E Tetngy of Flot os ofhisbody. Acegental serdar is cagrsec A @oOoThe corect anwar is. 74% chose this Kartagora's sya, ono cha, Is gous by adele In dln hat prevent elective move af sia Pel ‘ype ie caracenzed by sists, broeerad, sever, and male info. Cia play aninportan rea mag mucus serge away ond clang etre abeene of hs unten cnt fo piney Bing fhe Spat Cli re ls ety ora f leukosyie oer! ar phageyts Inert sprorortin mast patent ooo ircia iia, ‘is nt corset 15% chose this Destve cla tarps he cause oye fbroas. Cyste ftrosis fequeny eases brenchatsl, tts fot assecated wih Bis not correct. chose tls Paterte wt abet are prociaosecto ‘veloping eno firgal sats: Howaver, te orchard es ors re roteandetrt tn cables Dis not corroct. 7% chose this Mucus plugin mrad airway esbaso can cause etc ahe bing bases Aneay fimo chat of a pant wit acta ‘ira desace wcll evel hypenisie ings wth area of tls, ot ronchecaa, Es not correct. 3% chose this Taalogy of Flt is congenital near defect. unt Tol ssencaled th ifecinet cars mversen Patan wt his eandion vp at cjarsis beeuseof te malformed ightiode hurt Tha fou comperens of tre toratigy are [1] verter opal def, (2) evening aaa, noir ulnar staosis, na (4) gk wenbclarhypereopy. ‘Bottom Lins: [Kenagerars aprons caused by a fein nan at raves ace movement fella fle characarasd by sua, orca sus invereus, ae malin s @O942 anangement of wire, ‘sonal den ATP tks pore uence bending it spe hdgot dntt (Clini arch compe fa hea ara ‘pabmeied dere nd bon Each ‘ime 2GTP bond Input agli, oe opines Grove ou celles que Abo aed in lew ‘oplsni trsport in neon Molecule nt potsins tsps cla arg toad opie end fmt teks Broce eerie omer =) [ines =amtergac mcraile(- Kertagenr eome ‘moe lt do men tm defect Resin ale th eal fry per ote) bonlietn, nd mene cite (faces nc pile ot sbetot eciated ith Dig that at mires T Mtendsthitedale lannbeteniey 2 Geneon anifang) 3. Vintineinatine larteaneer 4 Pace Cant-tasteanen 5. Cabbie at goat) Chediak iguh ayo ~micminle Dameron dct(india racine compos of hls a Pulser iow of and tun Each ‘hiner ne 2CTP bound oped nt Sng cli mites pindes Gems y, cella qe Ak aed in slow ‘sophie trsportio neu “Maleelar mtr poten top cla can lonard epee end fmictaletl ‘Dyncine regi mirmbule >) Kishan to mcrae +4, ‘cytoskeletal elements (hacen a patie ot probed outs scien rogsthat at on mina 1 Meberdintitedale (anew) 2 Gch tif) 3. Vinciinehinblatine (antes 4. Pace, (antctrent cance) 5 Colchicine arog) Cink ish sone ict abner Sect ouling ia phage ema rctent pyngeie wtp bn pep neaopli ‘tnd mein Moi, nse conto, exons atheros janis, Micrombule ii els ties neurons, ends Interne Vieni dena keri, ly 2 prlian(OFAD), near “smn_Areabctonfegment lagi palmornim anaes ane pedlaee of amy lagued wth cyst feo haan Ose Sat ua generation, ‘nly th qrandnotordencrtrates symptom of isaee. Te grandatwr naa carer. Tha sand gore carr sane onoon, Aloft tire generators clssas srs cureny uncon -Acoucing te resticen Faget length pclymerphism anhss below, fz member of te thie gereraten has a chi wh a parner domensbaing symptoms of eye first, whi porsanhasa 50% chao of reduc acd elncalyafecod by oye Mc? a ae)denerevaing syncs eee frst, whl parsn fase 50% evens of pedueing ach elncalyefacesoyoyete Rrcle?The corect answer is 0.65% chose his Cystic Hbesis san auicenral ross dbease rast preva ne white population. The most amen gore cause ‘elon oft pony sanina ros te 908h prion oftwe CFTR gore Fora chit ‘Stave 9 80% chance of demarsainy skal irs an exam ces tieeare one pare must be camera hehe cre mist be arceygns otha nua Because be perm outde pare leaks be Synaral De tare membor ofthe third ganoraion must bean aaymptanaie carer. Grandhis D IS carter erty ease Te grandmeer nos he 2b reason fern er ‘lyme (RFLP), and to grancaeras lh tok and SK ot to RELP Thus, he lace wl acca fet archi has el the Kb Pagar A ‘arnerwl have al too RFLP (12K), ore 2K it comtaatn wth eon ne ‘arth kb ragmant Araneane can have Ikon Kte bath, Male KD, the cae of Grancht D, sh asa trae 1.20 ogres ‘Als ntcorect. 19% choee this. GrandchisrenA and ar affected bythe os ‘hey fave oly 2 2KD grt Tey have need two capes oft mata gore frombar pares, bot cfanom are caries Bothuculé have 100% chance ot Prodng an acted fering with he parr doecnbed Bs pot corect.t chose thi Grandi Bie untate by h disease She has "ik ano agen ony. She hoe hard to epee ote renra gene omer povent Cie not correct 13% chose the ranachlsren A ane Care aictd byte “hey have oly 9 2KD grt: Tey have need two capes oft mata gore frombar pares, bot cfanom are caries Bothuculé have 100% chance ot Prodng an acted fering with he parr doecnbed Es noteottect. 2% chose this. Gandhi Ele untae by the sense She hos nly Ho and 2Kb Fragman. Se hae ners vo copa th ermal gre fo nt poten, She come! produce a sympiomatc oeping ny esata s @O[Cyc trons autosomal recessive csease caused by dela of ha FOS rc of he GFTR gro, A carafe disease souks nave an RFLP signature arespanding oan tame alte an ano aed aol ‘loting procedures Souhembot ADNAampeisclemophorseden sgl and hen ttre oiler Te rte sed iv katt ad sibseqieny exposed toa ed DNA probe ta ecg ta anne ois complementary rnd The reins dbl ‘ted labled ice of DNA eve hen the iter espse to i Nonhaablot —Stnfateague,aeep st Noe ting ‘ale eaductve DNA probe binding simple NA, Westen at Sng psn separated via gel eectoporeis ‘dtu a le Lal atid el tobi to leat protein Modes of inertonce Aakomal ominant Ofer dco dees in sus genes Many ‘eneston, both mle and rl, SNA RP, Seuthim= DNA, Notuan= RNA Ware Passi (Oe peop adn ay cen peer clincaly er bor Fa soy xxl a dai @oOoAuta ecenive ‘tink domino Ofer eto deft in ssl genes Many ‘eneston, both mle and rl, 25% of ofiprngfom cae pane fk (Oe de tense deers Usually sen ony Tgeeion Scosefhetmmgous mote haves SO chance of nga No males anion “Tasted Song bs pres iter ale or Female open ef le feted ale ty (Oe peop adn ay cen peer clincaly er bor Fa soy ‘nate dag, Cannon eset than ‘onan dod patent lien prownt in hdbod, Hipophosphatemi ices emery own rin Binka dominant Tass shough ot arn Esher maleor —Uhpophosphatmi ket ene fying the eect wate ay former vo a Leafected wll al ons Aging fe Dees es, need Mkt fer ae deed Aborler ruling ‘heat asin poral {ube Ree innit ie esentiion Mioshonl ‘Trani ely though wither Allepeige Vidal teion i ‘hence ete rales show sis dese ‘plation doto sigh Mitchel mopatio, aber sheet optic seaopathy=degenetion ‘eal anion aisan son, Least ote eo ‘ental so, Poljmerase chin ‘Mele skey Mbt ocelot welts ied gue DNA, reaction a) Sep T Denattion DNA deat heating to gnente pate ana 2 Anmeing—doing cong ex petals DNA pinesann oa pci sence on each tnd to be aie 3. Elplias—beastae DIA pee ele the DNA sequen ch primes ‘Thee apt are pated lp iesforDNA sence agian a me!Teall hall ems pring of ie Mkt fer ae deed ‘heat asin poral {ube Ree innit ie esentiion Mioshonl ‘Trani ely though wither Allepeige Vidal teion i ‘hence ete rales show sis dese ‘plation doto sigh Mitchel mopatio, aber sheet optic seaopathy=degenetion ‘eal anion aisan son, Least ote eo ‘ental so, Mala isles Ebro racer welt snl ied gue f DNA, See T Denattion DNA deat heating to gnente pate ana 2 Anmeing—doing cong ex petals DNA pinesann oa pci sence on each tnd to be aie 3. Elplias—beastae DIA pee ele the DNA sequen ch primes ‘Thee apt are pated lp iesforDNA sence agian Aan gl etn ghocs—se fron urine PCR jess oles ‘ee te conmpated agus DNA edd, a me)[AGrnenhot ifs treught to her pednconberaus Whats te msi otogy of heals condi? of espratry ane feeding difcutes. On examiatn te iets wo ‘anc evahaten roves of verse onargonent wih ona act mon and way creas ae A ocld-Ghuosdese cefelaney Ajo“ S-gucosase decency . Galactose phoshateuiytransferese ‘ney 0 Glucne€ pophatse dtleny , Glycogen pspanfasedetcerey os A @oOoorga casas caueedy a Goiceney in i ieneamel ore a -osdaee “he cond characierzc by the atcumulten of cage neve, Ne ane helt misle, cate armel and ober yeni digs, sich ae ‘woshrec and mypotoni. Early deah ensues cit crcorespaey alr 1 is not correct. 7 chose this. Cas cieac0 ype gyogan tra sansa sautea bya deter nthe debranching enaye aro-18ghaoaiose. Te tanto causes the acamuaion of yong he hr, eat, ae keel mas, fda clay rales aa mie fama ype" gegen strage disease ‘haractrzod by std gem, hepatomegaly, hypogean mal ood Cis not comect 9 chose this Galeciee-tshsgheo utytranstrase san nay iolod in i exrersbn of galas to ucso--oxpha hich can then enter vat of tccaricel aetways such as geass or lccreogeesis. A ‘ofcioncy nh eneyna caus caste goalosoma, a conden characte the accumu eee substances (rluig galact) Na cause ifarsie Cataract hepatesplencregay, fare ine, and rata earn. reatrent Invests exclisn of galactose and core forthe it. Dis not correct. 9% chose thine shosphalae isa enya tat caaijeos tna sp af guconeogenei to produce gucse fam luce Shosphate Deficiency oh enzyme causes vn Gerke's dso, a hp 1 ghengon sarge tteease characteed by sinermal hyngenmtsbolsm ar an accumu ct ‘honpen hin or ols Syma rehoe saver arb hypapyama, epatmegay dus to neeoded angen lees in he ver a teased boo bata Es notcottect 10% chose this. sales dase so ype gheagen starage Aseabe caused by a defclency oft skeletal msce nye gizonen peephaylae. This ander causes an nd o break awn lysagen sores alta muscle reautng neil musta comps ana rysclocinute wt cuEls noteocect, 10) chose th \cAceles dissse i ype ghoogen serge tieeaen cased by 3 dnfoncy oho skloal musce ony gage respctylse Ths conden causes an ably o break coun ghsopen sees in "fetta isle, rosin nail msc ermps ana years wh rons ‘Bottom Lins: Fanpat dseare lead hypolaia, of vec evlargenent, and fea Talure ds san accurlaton cf henge secondary tency lot tunsdac, ‘cope storage 121) ll elise osm Ver Poor Cay eer tal an a action of een Metab valine, Disewe Fins Deficentnzsine Comets VouCiaies doene Sowteftinglnpephcenia,1T Glacae ‘oe “dhecgen ner! oad Sphere It hepatoma Popes Cadanga and yteni Uncut + Pompstasthe ‘oe Trdg leadagtoend death lusnudne etd Pap thet, be, allan) andmete, Coie dene Mile famoftpe wih emal —Debonshing sname Glaconngrnesie ‘ie ‘ct ee leriahicslie) it Teleogn intunck, bute Skeet mae Motutes= Mins, s @OBottom Line Pompas aeons leads a hypo lor aeoseace, Tavera enargemet, ST AID cope storage es 12 ppe alee in nen gheopen ncaa usta o ee hin cal Finding Seecrfatinginpegeemis, 1 ‘dyecgen ne Hod Ist tay (Carns and yt Ting leading en dent Miles fan fp ona ‘loll el 1 gheegen mace, batcamet Freedom nndrgto pal sce eps, myelin ‘thts ie Defic nena Chace ‘begat Lyman ‘cde id lls) Debraching enn (eigen) Shel nee shee phone Ver Poot Cade Metals, Cons Pore tabethe Pp he Ie, andmssley lieonrgen | Matus Mise @oOoAaiyearse boy rents that has boon soo bya doer Hie motor vague) roca hor shaving simiarprelens wor No wa a chi As parc os ‘skp the paterthes e ngetueevazclum dye eductn ost which iat wm Bue ile fn fang is oes in patent 1 Abana faces, engin hear defect, hypeparatyisn 15 beat response tnmnizaton 6. Paral aliism ae papal rouepathy 1. Recarontinfockns wih suscoptily ‘aati! aa ungelrgarisme E.Recurentpygericinfecton,eczaa, and trombeeyapene pupa os A @oOose anX Ind dre eauedty a doecin payin by nero ing oa ack oF ‘edad ncotnamig adenine dnuleode ghcspate (NADPH) cxdase actly. This Srey is oeponbi forth rsp bur! et procucse sparen (02am releculr oxygen (02), sig HADPH asa elcan dena. Supeerteproauced by [NADPH onsen im gies st 3 wd vray of eacve oxygen spies tat tae an important lena os’ defense agaist bacetalinecsors. Pater wh thi disease hve 2 med sop fo pera infockre wba ‘sepia Stopnyecaneus aureus Escherichia el ad Aeperiue. Tey mest cen resort under he ape of with ecuror psoas of mourn, oslo, Sbscasses ar citar sever ifociers Dogri Isbased on a negathe nice ferasium dypracicion for eth esi his tote poten ral ‘Ais not corset 9% chose hi These faoures ae ol hare iGoarge's arcmaly 2 congentlimmutodetcency discrdr ede, patents often faporeras hypocalcemia due to typopsrativoMior and a creased assay lnfecors. Ts aera caused by abromal enbnelegle developer ce anngeal actos and pauches, ans fen aac wih elena of acters 22911 is not correct. 4% chose his. Comincn vale mmunaciency is defer of Symphacjte msturaten Patents have pour or absent espanse to nun, 35 ‘all slow creations of gS, if, alr IgM Thay slr rom ein bactorl Inaction st oan sncpulronary act Thy ray alo present wih chic lung dicoas of asvaniosonel disoaee Cis mot correct As ehose thi. ChodakHgaci synirome a aasder of repens unton in when tar sa oft n ysosaal empsing of rego els {hs euteeomalecoslve dcr characeaed by recur ecto, prs abisn, ad pepral rurpaty. is depresed wih pepral toed sear demensvatng abomnal gat genes inreutoehis s toEs noteorrect. 10% chose ths. This iad of symatons(aogencirectens ‘ese, and thrombacypenc pupa} sand Wisk Ach sya Elovated IgA noma! gE now gh eves aro characte of Worth "ys, anXlnked tin te say 9 aun an igh responce caper Dlyscchaides of batter ators present wih e ted of symptoms, inccing Fecion! pyogenes, irenboryapeic papa, and zuma tom Line: [50's an inked eeerdorroeiigin aoc oF NADPH ox avy respon fr a pry bat Preeti tats Perea ‘Socal oper ieee Teepe iment ‘enamon inked), coeetoreeed {eins fade putes MHC sigs TReconentv bacterl, “np and pes infection deo Th Band Tea {een Tree ce ‘nl no alegt rekon TIL Vea 1 adenine = te to 8 snd Teal, Want, Loa, ‘yates Ditectin DNA par "Ti oebataree De eee eA decency. — lect ata), spider angiomas feta) eeseey ‘Water | Minka eoeave dea | Tia HIE THe aA TNL ‘ym Progrsiedltion of 8 tnd Teele, Phagte Tiloeyeaaheon | Defetin LFA nein] Resumen Boat] Neavopila Aefeescy(npet) | (CDIS)prtsinom | fection sent gos. ‘pe mest, {ely separation af ‘wnbie Ca ig Anesmal eases | Recon! poze ‘omone “fet wicetublar | ncn ty fini wih L stupoeoeciand Hugo Splococc patil aise peer seorop ‘Choc gamslamtoor | Lack NADIE Tracie ‘Negaive Niobe a= rece eee | erie ‘erszlom de oogunspece eg, | omnis ee, feito te opera) anda | Sever Ee, ere ee erat sceneRespiratory burst Lncbes the astaton sf meen ound NADP oie. neta, (orate bust acopag). lean important lei the nae spose rls i the ‘ap cles facie cngen intermediates (ROM) WHC fats th CGD can ie HO, ent by ding ogists ad ome ito RO, Pats tf rk forint yc potine specie, Sceuns Apagilni bees they teat hora Oy, evi WECS stat ROL fer hing nection s @O‘A Tyeero its babysting er sister, when sh ‘Tyearol gi cancer abouther posi PoSces that seas developed chy clusters of vesicular and crusted papular sins one faco, nk an am flung? daye of aero an over Alfani ss fmnvredcopletsy win 3 nook om fe eae ies, hich ott olor tess saul be used tei fis patents immune sta tote causev agant this infection? © A Blcodeutare © 8 Emymeinked nmuncenient 30) (© Nero nr © 0 Paymerase can eaten (© E Sout et os A @oOoThe corect mewsr is B12 chose ts.Enzyre-nkod nmurosorbot 3553) (ELISAs en mma nanque used obras determine he preseree of a parculr arity. nhs caso, ho patos srum woul bo exosod to vancala Zale angen paz ot on ELISA pte Labelod arr igG abodes are used ‘otetig6 abot agains ha vancala zoster vine ‘As not cone. 68% chose this Sod cares af the test fehl whan one Suspects a oclzad or systomic acta ifcicnncling sepsis, exeonyels, Imenngi and peumena Blood cures can detec be presence of ecais trgansms inte boos however. te prover norton about the paterts Immuratoscrespanse hat anise Cie not correct. 9% chose this Nora lets ae slarto Sou bit, xcept {hat Netom los akc or epee MRNA soguncos the past ator ha DNA, -Atough abodes ar encoded oy mRNA, each antibody bears aulaus niles Soqiore rood tay aforate gno ad mRNA sping. Hoes, Hora os antl be used detect te presence of anodes. Dis not corrct. 3% chose this Poljmraso chain roacton sa abr ochiquo ‘ose produce nary copie o 9 sagment of DNA. Ts tatiiqus canst e used 9 test wheter paral anbody spree Es not cotect. Me chose tis The gl fhe Stor toy i tdertty a Specie DNA sequen. Ins preccure, DNAs separated accorang 2 sing ‘lecropereaa desired rnatemed toa ter, al ybaed wih beled ONA, robe. Regons ene patents ONA but base-par wi te abeled DNA pcbes can be dena Since srtboties are rotens, nl DNA ts ecique camo! be used test wheher a pariculrantody preset n a petonts ood ‘Bottom Lins: ELISA an unsiegie tohnave used iabaraas to detarmina woeera pericarp (is cate an anibod fe present ina [patonts tos s @Onymetinted Ani inmunaleg tenis teting er immunosorbent fanigen antibod ech Seer GSA) Pasta se mpl thse feyg I Tokai engl eects . - enzyme) to ef fmmane ern tas 2. Test antibody (coupled to color genera agen Hmph cei) tenis ean antigen lithe targetancets rent nthe ample, Ne the tet sol me an nee clo Se, retin, ndesting patie test ws Eee ‘ting procedures Soubaublt DNA amples clctophoroedon 3 gel nd hen treme nate Te rte ood in leat ad abegaeny epoed oa bled DNA probe tat ceo tad anal ois couplanetay stent The roulng doble ‘usted abled pce of DNAs vtzed ‘hen thefts expe Nonharn blot Sinatehnige, capt Noten bling Involves tadintve DNA pode binding saiple NA, Wester et Sele pin scpnted vi eller tte ns lor Labeled antibody (se in ma orto to detente whether parc atiboy es, SEI poet n= fatent ood ser. Boh he sensiy and he speci of ELISA approach TO0%, tuto be pote and benepatve es a a me)Sot bt otha bla Westen bat ADNAumpleiscestopnresed on ageand then SNoW DROP. teamed oiler Te ler ithon sued ina Seuthmn= DNA, Alenterant sd oubegueny epee aided Nopbeam= RNA DNA poke tat meegnses and nein Wester = tin completa set The resuling dvb ‘tanded abled pice of DNA sized ‘whe teers expe el. Sinlrlechnige, cee hat Norn Mating ‘moles saute DN pre nding ple RNA, Somlepoe sepurted via gelesen ‘dune a lle, Cable nid ‘edt oe praten Malco prose ee anf ie ign of DNA, Sep 1 Dentrtion DNA. denature esting ogee 2p de 2 Anmelng—tingcolng ete remade DNA panes anneal toa pectic sesence tn cach tnd be amie 3. Fhe DNA plmense paste DNA sequence ing exchprine Tee tesa repeated malig tines for DNA sequence agian, Agate el clasnghoess—se forse epaton of PUR pect ale males aver compat agaist DNA s @OAmarth infant fam ase iigrated ails rough the erargercy deparment by hs mater, whois concerned because the chi ‘ae mol been fodng wal The rear ha sso riod tat ron Moe an sal odo, which she doses dan shy "Se ar hal She aid not rece ary prenatal care but ds a here wee no comlcaor cr te progtancy. On pyscl examination te irar appears {Sto mtomely pla an he skin soem dy ar ak Hoan soe lear The pater neg nd weigh area he 4h percent fr hs 208 “roement ofthis patort li os ky incu etary supcemertten wth which of the flung? 1 Aging 8 Ghtamate teasing 1 Tiyan E Tyrosine Q e e e e e F Valine os A @oOoThe corect sewer €, 60% chose hs Ths san nant wih pony (PkU} annum ar ef metabclam ha enue na defenoy of penylaine hyeroxjae, This enzo analy converte phenyl ne yrane. As rest of "ie defenoy,paylanine scouts, causing ea retarean, fare oh, ‘3 musty boo der, ae fas, arg ber ealiros infor wih PRU raquo Spel dt at hn yin and des ot eal eating ‘Alls ntconeet. 3% chose his.Argine sa bese amin acl that is ot lected in Pau Bs pot correct 1% cose tia. Gitomet at td to PKU Site el anemia resis fom apart mutation at canvers gutameo to vainein te B chain of enogacn Cie not comet S% chose this elaine anerpler emir acs that ot afodadin PRU Howove,sdbucr plas 2 ele mmapio yp uins5a50 Dis not comrct. 16% chose this. Tryopsn snd yes are easy conse hs Important ie remember at pteylalenne i converted to rosne, no oye, F isnot eorect. 15% chose ths. Vane sh amin a that eis om pant fiualon ste tal anomie le na elated Wo PRU Bottom Lins PRL a caused by a dacnay of pylons hycayae, wich canara phanjaanne a hrs Aa aeauh_phenjalanine accra, [esubing manta cetarsten fluro tive, ond a mst Sy acer Basse scene canna enger oe made om fis pay, became an lessoral amino eid an must be supolementd by th s @Ooot phnlnine yds or L Tenlydbioptrin cotton, Tyee ees natal pen bane lea ace hemletnes nae ge ment tration roth ciao, ‘sia fbi, cata tty dy en, ‘Teese penlnine ented ‘spate g,NulaSved) ad 1 enone inde Mate PRU lc of pope tary tory hg presancy. Fntis fn tcrceal ental retardation ont ‘etrdation, congetal at deecs Serna fn 23d sith luonmalat beh eease lel ee ding feta ie) Pherfcanes—phameste, ‘hen and hela Aula eee Tneience= 10,0 Diane of renting ‘eid metabo ny Tod odor: i ti tinal jhe ns ae a Ee pounm —> tame = s @O“The lneopren segues for the angpor and mateblem oases n Escher el and oer bactera The ibe arene regula by sera aca, ring ho avaltily of eatin substrates hat are dooce avec agent sch as Baodiets eaiton ‘hich fh along sbstancas wil alo be realy tect by Bendis ein? OA Celueee © 8 Mannos 0 esta 0 0 Sucrose (Esenato A @oOo‘The corect answer Is B. 20% chose ths.Te le aperanecomsceed three acerca genes a promos terns person tha proses Succes, na lac operon eum , Honavar. hte abuerce cf qhows end roserea ef lacne, th operon shined ch so hal fa bacora can now reaboize lactose. Sot gusoe ard tose sre ein agers, meaning thy eee ‘ith Boras colon to prods a bik rod propia Of answer eso, only Inennse seducing agen. Reducing sgar certain an alehyde grou, woh ‘ous Ci2+ inte Boned sion Gr Kamo tnt canary ‘autamarator tobe aos confgureton sich as fuses ar astern, can Seo ace eacing agen ‘Ata ot comet. 30% chose this Clluose ea pyascchaie caning of repeaing unis of Peres common fund in lant, aso rect ocr wh Benaditscaon Cis not comect. 1% chose this. Starch sa poysaccharde costing of repeating Unie guns Wreacte pot th Benet atonal. oe ‘eat ms numberof euig mote reser each carchyat's chains Dis not corrct. 32% chose this Siro naecng deaccharda consi oF !guamoe and fetose meee covalent by ayaa bad hich proves titer suger exmpanent ram reacting wh Bone son Bottom Line: Thc aperoneregilaled by he pesenon or abeoron of guces and lcceasvbeaes, oh agar are examples of educingeaScandas, meen By react reducing ages auch as Benet chon, Oe ediolng ages ude fctae, hyeradehyce,eabincee, end Ina s @OTha ke aparor is opuaieby he preseice or absrico of gicoea and lacove subsea, Boh spa ae examples of educag saccanias, nearing fey ract at redicing agers sich as Gane! schon, Ot rediong ageie ee ice, honradehye,aratinces, and rates ST AID Regulation of gene expression Trmater ‘Shewhere RNA peers and mil aber Tearcrpton facts bind DNA upton om, ge lous Ach ypstean sequence with ‘TATA nd CAAT bons Uinkancer Strch f DNA that her: gene epeion by ng ancien tr Slee Se shete mee eal pes bind Faction organization of the gone ‘mater miton como ests drama Aunt of ene nse, Linkancen and slenco may Ye leeted lee fom, ree within fina non Beg wee capo tegen @oOoA Syearaldboyprsens wn prolonged fague are ridjeunle follwing ase icon, Slo ters revel namin of 105 lek end Sn obvaedotlcyte count A porperal oad soar eveais Heine bode ‘hich fh along best doses th al action associated wth his patents metalic defect? [A To generate gluose- phosphate inal cls 5 To georate glucose-6phespate In ABCs ony To generate mucopaysaccharées 1. Toreganerte reduced ncoramie adenine ‘inyekones psa acl E To egorerate educa riconami adenine ‘inuloce phsonetsin RBCs cy ceo A @oOo“The coreetanawer fs DAT chose the lies Stays dehydrogenase (EPO) deter ohn mantessin young adutton or eclescons alsa sercus lnfecton Gente tan vars have been destbed ing te carmen (CePA end. G2°0 Mactanensen both oftich are Xinwed Henna SEP ‘erates rened nalearne adenine oletle phage NADPH) ern {liee lcoznamie aden crurleoe poschat NADP) which used > ‘eye gltatiane Reduced guahlone sed to deta) ealzing agent (ring agent are foun at mes cf facton, #8 ih can drugs such 36 Penaqine, and wih ngeton fava baa ead avem when syle, ‘Alls ntcorect. 12% chose tis Guzose-&shcephate is geerated tom luces by swlsnase ial High el of gus are prooess by glia ner Calls an panreste Boos Bis pot corroct. 15% chose this.lunso phosphatic goeraa fom glues by eweloase all cla Cie not comrct. chose thie Hus ease an Xinked ruropolysacchrkstat ross om a cteny of munmcysacchande reakaoun tisretosscoee wis patent pesernton E isnot eorect 20% chose this. The crverscn of hres hina (SOP) 6- phoaiuata (BPG) ee st te ne parse asp pata) (0. nm asthe nex mnophospate sunt) Ths para st procene NADPH (reducad NADP.) aflon a uoed losin areduoed pool of tations ls alsa so sto ft aes ane tras to gana to cyochera PED enaymo Soto, are ghogoayiags. 6G can bis caerted fo ibose5 assaf ue DRI synhnss,Thee processor coc nal el, ut defonoy oF GP has ho (tet etc cr Ea, wtih ave akame eon Yoda ang as Bottom Line [GEPD catcancyw an Ylnkad cawder af REC hat ana oh aocruaion ol reacive aygen apis het abeeqiery cave damagele ma C00 is atpanabl for acuing NADP? Ye NADP nn esos mere hur and husrmianng = eouee ct s @O[GIPO cefcency an Xlnkod coder of RBCe at lands oe aocuTuaion of reacive oxygen spaces fat sabeeniory cause dame ese cle. The ee GAPO segpnable fr teducing NADPY a NADPH es Neose merase Shut ard hus Malang @sovreeoF rccod gttncre clone NADPH isnacsny thee dushione duel, Nike weesie dle phosphate ‘whch te deter erate ad ‘to cen ume Setndrogenase Dpemsiee INADIH in RECs lendetohomolte eae define more ‘efceney ‘remade to por RBC dene sit pralentamongeels foidaingnget ef bea silfonmids, Tapa reste prise stabs dp Ist Can abo pect hems fe als stented vn nfm sep em ie {no RECs aden xiv dmg). ie cre fo the phagocytierenva ef Hee oe ee s @OReaction Oude a Nonoiatie ‘reveie) Paper so provide source of NADPH fa a sbundaniy ale han ‘howpate|NADHIL nro fr ects eins gtthone ection lade RBCs), Adina hisptay yl eo macotide tes ae sjcobtintrmedes 2 dnt piss fide and nonsidaie) bth o which ccuria the ejuplnn No ATP wed or produced, Stes ctatng mama gn Une nal on (ite of ty acd ort sts BCs Keynes Prades p_2Msone denyaogeane 02, em em ee Ree, rerLysosomal tomge eee Discas Sphilipidses Tb case Grichers doe (ot conc) Naan ek ‘iene te eee “Tyla dene Kutt die Metatuoratie Teak [Ea mney adden inone the may hana nes Resin tchrmalina of somal tbo Frings Dasicica cnnine espa napa | Tae geen, cadocscubteal deans Hepstencmea Sel eects far, tome er Couche set [scpge that ke cramped te opt Pragereneweteeorabon, Sphingamylase Tepaplenemei cher lpaton cal, fume placid Palaccerone Pragevenewedenabon, ‘event dl, ‘her sed spt oa masa, Janet aon sie epoca ‘eww Peper naa, drelemenl dy, ie sty, lle cl (cot at pepo elton ih i, Cahetoebrote Anatase A Accom te Insite Cenmide xn ‘ian Chcncertbrrde AR Sphingonyein GN omehse Cabtcenbroe Cochise s @Osnes wa nion s, pater Noman ik Kibbvidiene ephemera, “clipe deb ee ao lke cl Metacuoutic Conta nd epee Teuktophydeumelnatn wh tab, ‘mene ‘Macopenaceons Huttssivinne Delgo dey, aun ‘remiss Situcton, coed ‘hating euenemey Hutetsniome MidHukfsagosve lune sline "who oc ching scram zee mt ae ene Hagar lite, “enta sie Noma ps Nisan Pick ‘iene ih behing (phangeeyetincd, Teale se es na comeal ‘ning| sin to (Slinkedraeae) Vince oT Sac, Nini and ove foms ‘i Couchers den ‘Renae_AGmantlé bose tought oth pysoen,becauee he saeme slr te iri is eg8 andes sastnal vaingaseclate ih toed ik endings. Onc exaninaton, he pao ound have audio, istorl caucngcFeyelbnes, ard hapatonegay. The Patera shows signs of deveepmertal ely hich ote folonirg enzymes i ikey tobe detective in his condion? © A ey Hverayase © 8 Aldse © © Galactose phonateulytransterase © 0 aurnesutase OE Tansmemerane coppertansporting ATPase os A @oOo‘The coreet answer is. 51% osetia Tis boy's preseriaon sugges classe gslaccrenia Classic galactsemia has autosomal acess ihetance and resus Ietlenay of galotne- tose uanalerage Wit is enzyme respond galactose comet ccrvatd to phosphite lucseto be usedin (holy and guconoajeness As a eau golcset-arpte saurules in “aros gars nooo cui he cel reneus stam Wer, ana ees. Glucose an istse (rl suis be avean patent wh his canton Giactoknase deficiency resign galactose is als a psi nfs case However, te presen symptoms wal bss sews, cus only ft ‘atari ana developer delays related 0 sit Jack a devakpment fe soc ‘ead tabity tak et) ‘Alls nt coreet 31% chose this.ot Hyéroiase converts call clei. and operates nth pros itua oft Woy Rie ossonia for ereabg 125101 ‘amin hs absence may be associated wit mypocalcemle ar nceased partir homano formar. Hypealcomi i asacal associat wietny and euruscuar aby 1 is pot correct. 10% chose this Akins B dain causes cen incor, ‘ealtngnucee-ghanphate acumaltan, Ava rosy avalabe reapate drop, ana tom guccroegensi ar gjcopeeyss aro inhisted. Te cna manfosaions ince hypogemafundcs, sates, and vanity This 9 a resemaon or ‘otha of aesc galactosomi, but cataracts aolypcaly nota preston oat n fase 8 defen. 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