Direct Agonists Muscarinics = Methacholine Affect = Acetylcholine Cardiac = Carbachol Pulse = Pilocarpene But = Bethanechol Nicotinics = Nicotine Clench

= Cevimeline **This one's a two for one since it also hints at how the diff receptors work (muscarinics affect the heart rate, while nicotinics affect the neuromuscular junction). Anti AchE's: New Physicians Endure Pimping = Neostigmine = Physostigmine = Edrophonium = Pyridostigmine

Alzheimer's Drugs (also Anti-AChE's): Grandma = Galantamine Doesn't = Donepezil Remember = Rivastigmine Today = Tacrine Hints: 1. For the Ach antagonists, just remember that most of them look similar to atropine (they have trop, rop, or pine in them). Exceptions are scopolamine, tolterodine, and oxybutynin. 2. For skeletal muscle relaxants (neuromuscular inhibitors), they all look similar to tubocurarine (have a cur in them). Exception is mecamylamine, which has a different mechanism anyways. 3. ACh agonists generally elicit the "rest and digest" response from the body, such as slower HR, increased secretions, increased GI motility, etc. 4. ACh antagonists (atropine) do the opposite: the "fight or flight" response. This includes increased HR, decreased secretions and motility, pupil dilation, etc.