PREDISPOSING FACTORS

Modifiable Non Modifiable

Alcohol drinker

Excessive eating of fatty foods

Smoker

Male

Hx of CVA

Family Hx of HPN

Age ( 53 yrs)

Accumulation of fats into the blood

Presence of nicotine in the blood

Adherence of fat plaques in the aortic knob Nicotine adheres to the blood vessels causing narrowing of vessels

Blood vessels thickens in diameter

Blood vessels narrow

Decrease blood vessel elasticity

Fat dislodge and circulate in the general circulation of blood Fats adhere to the blood vessels

Lodge on the R occipital lobe of the brain

Blood vessels narrows

Infarction

Hypertension BP= 180/140 mm Hg

Decrease cardiac output

Decrease O2 supply in the right occipital lobe Activation of renin-angiotensin-aldosterone system ischemia angiotensinogen Energy failure Increased aldosterone level Acidosis Ion imbalance Increase capillary permeability causing shift of sodium from the intracellular spaces to extracellular spaces Sodium retention Angiotensin II Angiotensin I

Increase glutamate Intracellular Ca increase

Depolarization

Water retention

Brain membranes and protein breakdown Formation of free radicals Protein production decreases

Cell injury on right occipital lobe of the brain

edema Impaired vision hallucination