Avian influenza (bird flu) is an infectious disease of birds caused by type A strains of the influenza virus.

The infection can cause a wide spectrum of symptoms in birds, ranging from mild illness, which may pass unnoticed, to a rapidly fatal disease that can cause severe epidemics. Avian influenza viruses do not normally infect humans. However, there have been instances of certain highly pathogenic strains causing severe respiratory disease in humans. In most cases, the people infected had been in close contact with infected poultry or with objects contaminated by their faeces. Nevertheless, there is concern that the virus could mutate to become more easily transmissible between humans, raising the possibility of an influenza pandemic. -Who antigenic drift. These are small changes in the virus that happen continually over time. Antigenic drift produces new virus strains that may not be recognized by the body's immune system. This process works as follows: a person infected with a particular flu virus strain develops antibody against that virus. As newer virus strains appear, the antibodies against the older strains no longer recognize the newer virus, and reinfection can occur. This is one of the main reasons why people can get the flu more than one time. In most years, one or two of the three virus strains in the influenza vaccine are updated to keep up with the changes in the circulating flu viruses. So, people who want to be protected from flu need to get a flu shot every year. The other type of change is called antigenic shift. Antigenic shift is an abrupt, major change in the influenza A viruses, resulting in new hemagglutinin and/or new hemagglutinin and neuraminidase proteins in influenza viruses that infect humans. Shift results in a new influenza A subtype or a virus with a hemagglutinin or a hemagglutinin and neuraminidase combination that has emerged from an animal population that is so different from the same subtype in humans that most people do not have immunity to the new (e.g. novel) virus. Such a shift occurred in the spring of 2009, when a new H1N1 virus with a new combination of genes emerged to infect people and quickly spread, causing a pandemic. When shift happens, most people have little or no protection against the new virus. While influenza viruses are changing by antigenic drift all the time, antigenic shift happens only occasionally. Type A viruses undergo both kinds of changes; influenza type B viruses change only by the more gradual process of antigenic drift. cdc Vaccination is the administration of antigenic material (a vaccine) to stimulate an individual's immune system to develop adaptive immunity to apathogen. Vaccines can prevent or ameliorate morbidity from infection.

A pandemic is an epidemic of infectious disease that has spread through human populations across a large region; for instance multiplecontinents, or even worldwide. Morbidity refers to the state of being diseased or unhealthy. It is an incidence of ill health in a population. It reprted by: World Health Statistics (compiled by WHO), MMWR (Morbidity and Mortality Weekly Report, by Center for Disease Control and Prevention, USA), EMDB (European hospital Morbidity Database, Europe), NHMD (National hospital morbidity Database, Australia). Mortality is the term used for the number of people who died within a population. It refers to the incidence of death or the number of deaths in a population. The Human Mortality Database developed by for example: the Department of Demography at the University of California, Berkeley and the Max Planck Institute for Demographic Research in Rostock Germany.

How Influenza Viruses Change: Drift and Shift

Influenza viruses are dynamic and are continuously evolving. Influenza viruses can change in two different ways: antigenic drift and antigenic shift. Influenza viruses are changing by antigenic drift all the time, but antigenic shift happens only occasionally. Influenza type A viruses undergo both kinds of changes; influenza type B viruses change only by the more gradual process of antigenic drift. Antigenic drift refers to small, gradual changes that occur through point mutations in the two genes that contain the genetic material to produce the main surface proteins, hemagglutinin, and neuraminidase. These point mutations occur unpredictably and result in minor changes to these surface proteins. Antigenic drift produces new virus strains that may not be recognized by antibodies to earlier influenza strains. This process works as follows: a person infected with a particular influenza virus strain develops antibody against that strain. As newer virus strains appear, the antibodies against the older strains might not recognize the "newer" virus, and infection with a new strain can occur. This is one of the main reasons why people can become infected with influenza viruses more than one time and why global surveillance is critical in order to monitor the evolution of human influenza virus stains for selection of which strains should be included in the annual production of influenza vaccine. In most years, one or two of the three virus strains in the influenza vaccine are updated to keep up with the changes in the circulating influenza viruses. For this reason, people who want to be immunized against influenza need to be vaccinated every year. Antigenic shift refers to an abrupt, major change to produce a novel influenza A virus subtype in humans that was not currently circulating among people (see more information below under Influenza Type A and Its Subtypes). Antigenic shift can occur either through direct animal (poultry)-to-human transmission or through mixing of human influenza A and animal influenza A virus genes to create a new human influenza A subtype virus through a process called genetic reassortment. Antigenic shift results in a new human influenza A subtype. A global influenza pandemic (worldwide spread) may occur if three conditions are met: a. A new subtype of influenza A virus is introduced into the human population. b. The virus causes serious illness in humans. c. The virus can spread easily from person to person in a sustained manner.

Tanya? how to overcome the outbreaks of avian influenza? How Influenza Viruses Change: Drift and Shift