Tammemagi Lung Cancer Risk Prediction Calculator Calculator predicting 6-year risk of lung cancer by the Tammemagi (PLCOM2012)

) model.* Instructions: For the characteristics described in Column A fill in the individual's values in Colum Note: Values in columns C to F can be ignored and should not be changed. Enter Centered or Characteristics to be entered Values referent group Age in years Education (enter the highest level obtained) 1 = less than high school grad; 2 = high school grad; 3 = Post high school training; 4 = Some college; 5 = College grad; 6 = Postgraduate/professional. Body Mass Index (BMI, weight in kg/height in meters^2) COPD, emphysema or chronic bronchitis (0=No; 1=Yes) Personal history of cancer (0=No; 1=Yes) Family history of lung cancer (0=No; 1=Yes) Race/ethnicity White (referent group) (0=No; 1=Yes) Black (non-Hispanic) (0=No; 1=Yes) Hispanic (0=No; 1=Yes) Asian (0=No; 1=Yes) American Indian/Alaskan Native (0=No; 1=Yes) Native Hawaiian/Pacific Islander (0=No; 1=Yes) Smoking status, 0 = Former-smoker 1 = Current-smoker Average number of cigarettes smoked per day** Duration smoked (years) Years ago quit smoking. Enter zero for current smokers. Model constant 1 0 0 0 0 0 0 20 30 15 0.097845839 27 10 55 62

28 0 0 0

27 0 0 0

Probability of lung cancer =

0.005

* Reference: Tammemagi et al. Selection Criteria for Lung-Cancer Screening . NEJM. 2013;368(8):728-3 ** Transformation of smoking intensity =(((H_smokdday/10)^-1)-0.4021541613) Example: The 6-year risk of lung cancer in a white individual who is 55 years old, has some college education, a BMI of 28, who is a former smoker who quit 15 years ago and smoked on average 20 cigarettes per day for 30 years is estimated to be 0.005 or 0.5%. NOTE: This calculator was developed and tested in Microsoft Excel for Mac 2011 version 14.0.0.

Version 22FEB13MT COM2012) model.* dividual's values in Column B. Coefficient 0.0778868 Contribution to estimate -0.5452076 ORs 1.08

-0.0812744

0.92

-0.0274194 0.3553063 0.4589971 0.587185

-0.0274194 0 0 0

0.97 1.43 1.58 1.80

0 0.3944778 -0.7434744 -0.466585 0 1.027152 0.2597431 -1.822606 0.0317321 -0.0308572 -4.532506 xb = EXP(xb) =

0 0 0 0 0 0 0 -0.178334413 0.0951963 -0.154286 -4.532506 -5.342557113 0.0048 2.79 1.30 nonlinear 1.03 0.97 1.48 0.48 0.63

g . NEJM. 2013;368(8):728-36.

ac 2011 version 14.0.0.

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