sham poo shampoo

o o p m a h am poo Sh S

Innovative kerato-regulating and emollient shampoo with antifungal properties

N O I T A L U M R O INNOVATIVE F
1. 10% Urea 2. 5% Lactic Acid 3. 2% Salicylic Acid 4. 1% Octopirox

Effective Desquamation Antifungal properties

The ideal Partner in adjunctive scalp seborrheic dermatitis and psoriasis therapy. penetration of Rx products.
Note: RAXAL Shampoo is not a medicine

o mpo a h S is

o mpo a h S provides desquamation, which may enhance

Control

Octopirox

The with Octopirox 1% 2 effective is highly against Malassezia species which are 1 considered to be The main cause of 0 dandruff
Fungus growth (score) 0,001% 0,002%

poo m a Sh

In Vitro activity of Octopirox towards Malassezia sp.

4
Control Octopirox

7 6 5 4 3

Fungus growth (score)

2
0

0,001%

0,002%

0,004%

0,008%

0,016%

1 0

Concentration of active ingredient

0,004%

0,008%
Dandru severity Score

0,016%
+ Zinc Pyrithione 1%

15 Concentration of active ingredient

Octopirox 0,75% / Salycilic Acid 2%

N: 19 PATIENTS Use twice weekly

Octopirox and 2% Salicylic acid work synergistically

15

10

+ Zinc Pyrithione 1%

Octopirox 0,75% / Salycilic Acid 2%

N: 19 PATIENTS Use twice weekly

Dandru severity Score

0 0

-71% with the The shampoo combination of

5 10

10

-71%
0 5 10 15 20 25

Octopirox + Salicylic acid appears more effective

Days
15 20 25

than zinc pyrithione shampoo

Days

M. Loden and C. Wessman: The antidandruff efficacy of a shampoo containing piroctone olamine and salicylic acid in comparison to that of a zinc pyrithione shampoo: Int.Journ.of Cosm. Science: 22: 2000: pp 285-289

Density Malassezia yeast - 1% Octopirox Vs 1% Ketoconazole

Malassezia sp. (N/mm-2)

N: 21 Volunteers with severe dandruff Day 1 (before shampoo) Day 1 (after shampoo) Day 4

5 min residence time

. 1% Ketoconazole shampoo
159 (98-206) 90 (35-145) 96 (64-179)

. 1% Octopirox shampoo
159 (120-230) 77 (27-162) 110 (55-155)

C. Pierard-Franchimont et al: Effect of residence time on the efficacy of antidandruff shampoos: Int. Journ. Of Cosm. Science: 25: 2003: pp267-271

The 1% Octopirox shampoo shows comparable efficacy to 1% Ketoconazole 80 shampoo. 70

o o p m a h S

60 50 40

sham poo shampoo

o o p m a h am poo Sh S

Effective dandruff management Effective desquamation Antifungal properties Reliefs from scalp itch Can be combined with other scalp topical therapies and may accelerate treatment outcomes Restores balance and shine of the hair
Directions:
m Wet hair and gently massage a small amount of Sha into hair and scalp. Leave 3-4 minutes before rinsing. Repeat 2-3 per week. o mpo once per After optimal results achieved use Sha week. poo

200 ml

the touch of uniqueness

28-30 Hansen str., 111 44 Athens, Greece el.: (++30) 210 2110614 info@cheironpharma.com www.cheironpharma.com