Human CD Antigens

B Cell Antigens
CD5 CD19 CD20 CD22 CD23 CD25 CD40 CD69 CD70 CD79a CD79b CD80 CD86 CD137 (4-1BB) CD138 (Syndecan) CD252 CD268 Antigen Name CD1a CD1b CD1c CD1d CD1e
CD2 CD2R CD3 CD3 CD3 CD4 CD5 CD6 CD7 CD8 CD8 CD9 CD10 CD11a CD11b CD11c CD12 CD13 CD14 CD15 CD15s CD15u CD16a CD16b CD17 CD18 CD19

Alternate Names T6, Leu-6, R4, HTA1 R1 R7, M241 R3 R2

T11, LFA-2, SRBC-R T11-3 T3D T3E, Leu-4 T3G T4, Leu-3a T1, Tp67, Leu-1 T12 Leu-9, gp40 T8, Leu-2 Leu-2 p24, MRP-1 CALLA, NEP, gp100 LFA-1, integrin L, ITGAL Mac-1, integrin M, CR3, ITGAM p150,95, CR4, integrin X, ITGAX

MW (kD) 49 45 43 49 28
50 50 20 20 25 55 67 100-130 40 32-34 30-32 22-27 100 180 170 150

Distribution cortical thymocytes, Langerhans, DC cortical thymocytes, Langerhans, DC cortical thymocytes, Langerhans, DC, B subset cortical thymocytes, intestinal epithelial cells DC (Golgi compartments, endosomes, and lysosomes) thymocytes, T, NK, B Tact T, thymocyte subset
T, thymocyte subset T, thymocyte subset thymocyte subset, T subset, monocyte thymocytes, T, B subset, B-CLL thymocytes, T, B subset hematopoietic progenitors, thymocytes, T, NK, T-ALL thymocyte subset, T subset, NK thymocyte subset, T subset pre-B, eosinophils, basophils, platelets, Tact B precursors, T precursors, neutrophils lymphocytes, granulocytes, monocytes, macrophages myeloid, NK, monocytes DC, myeloid, NK, B subset, T subset monocytes, granulocytes, platelets myeloid cells, AML monocytes, tissue macrophages granulocytes, neutrophils, eosinophils, monocytes neutrophils, eosinophils, monocytes, memory T, Tact, B, NK, HEV myeloid subset neutrophils, macrophages, NK, mast neutrophils neutrophils, monocytes, platelets, granulocytes, basophils, B subset all leukocytes B, FDC

Function lipid and glycolipid antigen presentation, w/2m lipid and glycolipid antigen presentation, w/2m lipid and glycolipid antigen presentation, w/2m lipid and glycolipid antigen presentation, w/2m lipid and glycolipid antigen presentation, w/2m
adhesion, T cell activation activation-dependent form of CD2 associates with TCR, TCR surface expression, signal transduction associates with TCR, TCR surface expression, signal transduction associates with TCR, TCR surface expression, signal transduction T cell differentiation, activation TCR or BCR signaling, T-B interaction T cell differentiation, costimulation T costimulation T cell differentiation, activation T cell differentiation, activation cellular adhesion and migration zinc-binding metalloproteinase, B cell development intercellular adhesion, T costimulation, heterodimer with CD18 adhesion, migration, heterodimer with CD18 adhesion, migration, heterodimer with CD18 zinc-binding metalloproteinase LPS sensor adhesion adhesion adhesion component of low affinity Fc receptor, phagocytosis and ADCC component of low affinity Fc receptor, phagocytosis and ADCC adhesion, phagocytosis heterodimer with CD11a, b and c, adhesion

Ligand/Receptor CD1 restricted TCR CD1 restricted TCR CD1 restricted TCR CD1 restricted TCR
CD58

Antigen Name Alternate Names CD85k LIR5, ILT3, HM18, LILRB4 CD85l ILT9, LILRP1 CD85m ILT10 CD86 B70, B7-2 CD87 UPA-R, PLAUR
CD88 CD89 CD90 CD91 C5aR C5R1 FcaR, IgA-R Thy-1 2MR, LRP1 p70, CHTL1. CDw92, SLC44A1 C1qRp

MW (kD) Distribution 60 DC, macrophages, monocytes, pDC, endothelial NK, T subset, monocytes, macrophages, DC, B NK, T subset, monocytes, macrophages, DC, B 80 monocytes, DC, Bact and Tact 39-66 monocytes, NK, Tact, endothelial, fibroblasts
43 55-75 25-35 600 70 120 granulocytes, monocytes, macrophages, DC monocytes, macrophages, granulocytes, neutrophils, B subset, T subset HSC, neurons

Function thought to be an inhibitory receptor

associates with FcR associates with FcR T costimulation inflammatory cell invasion, metastasis, extracellular matrix degradation granulocyte activation phagocytosis, degranulation, respiratory burst

Ligand/Receptor

CD28, CD152 uPA, vitronectin C5a receptor IgA1, IgA2 CD11b/CD18 2-macroglobulin, LDLs, HSP96 choline C1q, MBL2, SPA CD178 (FasL) CD155 CD55

Antigen Name CD208 CD209 CDw210a CDw210b CD212 CD213a1 CD213a2 CD215 CD217
CD218a CD218b CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227

Alternate Names LAMP3, DC-LAMP DC-SIGN IL10RA, IL-10R IL10RB, IL-10R IL-12R1, IL12RB1 IL-13R1, IL13RA1 IL-13R2, IL13RA2 IL-15R IL-17R
IL18R1, IL-18R, IL-1Rrp IL-18R, IL18RAP INSR, Insulin-R IGF-1R, IGFR IGF2R, M6P-R LAG-3 GGT1 Leu-13 DNAM-1, PTA-1, TLiSA1 MUC1, EMA MF12, Melanotransferrin Ly-9 PRNP, Prion protein TSPAN7, TALLA-1 PLXNC1, VESP-R

hematopoietic stem cell and neuron differentiation, adhesion, signal transduction monocytes, macrophages, neurons, fibroblasts lipid homeostasis, signal transduction neutrophils, monocytes, granulocytes putative ligand transporter clearance of apoptotic cells, adhesion complex w/ NKG2, inhibits NK function apoptosis adhesion of activated T and NK adhesion, signaling cellular activation, adhesion T cell activation, adhesion isoform of CD99 cell adhesion, cellular activation T cell activation costimulation, adhesion, lymphocyte recirculation heterodimer with 7, lymph homing/retention heterodimer with CD49f, cell adhesion, differentiation, metastasis cellular response to TGF1, adhesion, embryonic angiogenesis leukocyte adhesion, migration, costimulation lysosomal membrane protein lysosomal membrane protein putative role in inflammation negative regulator of TGF in keratinocytes regulates megakaryocyte and platelet formation intercellular adhesion intercellular adhesion adhesion molecule that interacts with afadin myeloid differentiation/proliferation monocytic differentiation/ proliferation associates with CD131, myeloid differentiation/ proliferation hematopoietic progenitor development/ differentiation associates with CD130, signal transduction, soluble form inhibits activity of LIF associates with IFN- AF-1, host defense

MHC class II, HIV CD72 CD166 MHC class I MHC class I CD50, CD54, CD102 CD54, CD102, iC3b, fibrinogen, CD23 CD54, iC3b, fibrinogen, CD23 corona virus receptor LPS receptor CD62L, CD62P aggregated IgG IgG

CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD99R CD100 CD101 CD102 CD103 CD104 CD105 CD106 CD107a CD107b CD108 CD109 CD110 CD111 CD112

Dendritic Cell Antigens

CD1a CD1b CD1c CD11c CD14 CD40 CD49d CD80 CD83 CD85g (ILT7)pDC CD86 CD123pDC CD197 (CCR7) CD205 (DEC-205) CD207 (Langerin) CD209 (DC-SIGN) CD273 (B7-DC) CD289 (TLR9) CD303 (BDCA2) CD304 (BDCA4)

90-120 Aminopeptidase N, 150-170 APN, gp150 LPS-R 53-55 Lewis-x, Lex, SSEA-1 Sialyl Lewis X Sulfated Lewis X FcRIIIA FcRIIIB lactosylceramide, LacCer Integrin 2, ITGB2 B4 B1, Bp35 C3DR, CR2, EBV-R BL-CAM, Siglec-2 FcRII BA-1, HSA Tac, p55, IL-2R DPP IV T14, TNFRSF7, S152 Tp44, T44 Integrin 1, platelet GPIIa, ITGB1 Ki-1, Ber-H2 50-65 48 115-165 95 95 33-37 110, 145 150 45 35-45 55 110 50-55 44 130 105-120

neutrophils, monocytes, endothelial, granulocytes, NK, platelets Kp43, KLRD1 43 NK, T subset Apo-1, Fas, TNFRSF6 45 lymphocytesact, monocytes, neutrophils TACTILE 160 Tact, NK BL-KDD/F12 74, 80, 90 Tact, B, monocytes. macrophages, granulocytes, DC 4F2, FRP-1, SLC3A2 40, 80 monocytes, Tact, B, and NK MIC2, E2 32 leukocytes E2 32 T, NK, myeloid cells, thymocytes Sema4D 150 hematopoietic cells except immature BM cells, RBC and platelets V7, P126, IGSF2 120 monocytes, granulocytes, DC, Tact ICAM-2 55-65 monocytes, platelets, endothelial ITGAE, HML-1, 25, 150 intraepithelial lymph, lymph subset, activated integrin E lymph 4 integrin 220 epithelium, Schwann cells, keratinocytes, some tumor cells Endoglin, ENG 95 endothelial, BM stroma, activated monocytes VCAM-1, INCAM-110 110 LAMP-1 110 LAMP-2 SEMA7A, JMH Platelet activation factor, 8As, E123 TPO-R, C-MPL, PRR1, Nectin-1, PVRL1, Hve C1 PRR2, Nectin-2, HVEB PVRL3, Nectin3 G-CSFR, CFS3R M-CSFR, c-fms, CSF-1R GM-CSFRa c-kit, SCFR LIFR, gp190 IFNGR1, IFN-R TNFR-I, TNFRSF1A TNFR-II, TNFRSF1B IL-1R type I, IL1R IL-1R, type II IL2RB IL3RA IL4R IL5RA IL6R IL7R IL9R 120 80 170 82-84 64-72 64-72 83 95, 139 150 70-85 145 190 90-100 50-60 75-85 80 60-70 75 70 140 60 80 65-75 64 endothelialact, FDC plateletsact, T, endothelial, granulocytes, macrophages, DC, metastatic tumors plateletsact, T, endothelial, granulocytes, metastatic tumors erythrocytes, lymphoblasts Tact and platelets, CD34+ subset, endothelial, HUVEC megakaryocytes, platelets, some CD34+ stem cellslow stem cell subset, macrophages, neutrophils

MW (kD) Distribution 70-90 DCact, interdigitating DC 44 DC subset, macrophages T,B, NK, monocytes, macrophages T,B, NK, monocytes, macrophages 100 Tact, NKact 65 B, monocytes, fibroblasts, endothelial 65 B, monocytes, fibroblasts, endothelial T, B 120 B, T, NK, granulocytes, monocytes, macrophages 70 lymphocytes, neutrophils, monocytes, granulocytes, endothelial, NK, DC 70 T, NK and DC 140, 70 leukocytes, fibroblasts, endothelial, epithelial 70, 140 broad expression 250 fibroblasts, granulocytes, lymphocytes and myocytes, 90-95% intracellular 70 Tact and NK 27, 68 lymphocytes, monocytes, granulocytes, endothelial, stem 17 leukocytes, endothelial 65 T, NK, monocytes, platelets, HUVECact
300 80-95 95, 110 35 30-45 200

Function putative role in sorting MHC Class II involved in innate immunity, HIV-1 binding protein signaling
associates with IL-12 receptor 2 associates with CD124 signaling associates with CD132 and CD122 involved in inflammation associates with CD218b associates with CD281a to enhance IL-18 binding signaling signaling, cell proliferation, differentiation adhesion, tumor growth

Ligand/Receptor
CD50, CD102 IL-10 IL-10, IL-22 IL-12 IL-13 IL-13 IL-15 IL-17 IL-18 IL-18 insulin IGF-I, IGF-II, insulin TGF-LAP, plasminogen, proliferin, LIF, IGFII, HSV MHC class II

CD72, plexin B1 CD11a/CD18 E-Cadherin laminin TGF1, TGF3 CD49d/CD29, CD49d/7 galectin-3, CD62L, C62E, CD62P galectin-3, CD62L, C62E, CD62P CD232 thrombopoietin CD112, CD113, CD155, nectin-4 CD111, CD113, CD155 CD111, CD112, CD155 G-CSF M-CSF GM-CSF SCF LIF Ifn TNF, TNF TNF, TNF IL-1, IL-1, IL1ra IL-1, IL-1, IL1ra IL-2, IL-15 IL-3 IL-4, IL-13 IL-5 IL-6 IL-7 IL-9 oncostatin M, IL-6, LIF

CD228 CD229 CD230 CD231 CD232 CD233 CD234 CD235a

lymphocyte activation maintains cellular redox, maintains intracellular glutathione (GSH) concentrations associates with complexes of CD81, CD19 and CD21 intercellular adhesion, lymphocyte signaling, cytotoxicity, associates with CD11a/CD18 epithelial, stem cell subset, FDC, monocytes, B adhesion, signaling subset, some myelomas stem, melanomas iron transport adhesion, costimulation, homophilic interaction protects cells from apoptosis marker for T-ALL associates with CD108 and poxvirus semaphorin-like protein A39R anion exchanger pump, transport of CO2, linking red cell membrane to cytoskeleton chemokine decoy receptor major sialoglycoproteins of the erythrocyte membrane, antigenic determinants for the MN and Ss blood groups major sialoglycoproteins of the erythrocyte membrane, antigenic determinants for the MN and Ss blood groups Gerbich blood group antigen Gerbich blood group antigen zinc endopeptidase adhesion, signaling Rh blood group system Rh blood group system complex with CD47, LW, glycophorin B adhesion, Landsteiner-Wiener blood group ATP-dependent efflux transporter NK activation, T costimulation signal transduction; costimulation of T and NK brain development, implicated in ALK lymphomas

CD112, CD155 CD54, CD169, selectins iron, pro-UPA, plasminogen CD229

Band 3, SLC4A1, EPB3 90 Duffy, DARC Glycophorin A 35-45 36

T, B neurons, FDC T leukemias, neuroblastomas, brain neurons B, NK, DC, neuronal cells, monocytes, granulocytes erythrocytes erythrocytes, endothelial, epithelial erythrocytes, HSC

CXCL1, CXCL5, CXCL8, CCL2, CCL5, CCL7 CD170, influenza virus, erythrocyte binding antigen (EBA-175) of Plasmodium falciparum

CD235b CD236 CD236R CD238 CD239 CD240CE CD240D CD241 CD242 CD243 CD244 CD245 CD246 CD247 CD248 CD249 CD252 CD253 CD254 CD255 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD270 CD271 CD272 CD273 CD274 CD275 CD276 CD277 CD278 CD279 CD280

Glycophorin B Glycophorin C/D Glycophorin C Kell B-CAM Rh30CE, RHCE Rh30D, RhD, RH1 RhAg, Rh50 ICAM-4 MDR-1, p170, P-gp 2B4, p38 , NKLR2B4 p220/240, DY12, DY35 ALK TCR, CD3 TEM1, Endosialin Aminopeptidase A OX-40 Ligand, gp34, TNFSF4 TRAIL, APO-2L, TL2, TNFSF10 TRANCE, RANKL, TNFSF11 TNFSF12, TWEAK, APO3L APRIL, TALL-2, TNFSF13 BLyS, BAFF, TNFSF13b LIGHT, TNFSF14 TRAIL-R1, DR4, TNFRSF10a TRAIL-R2, DR5, TNFRSF10b TRAIL-R3, DcR1, LIT, TNFRSF10c TRAIL-R4, TRUNDD, DcR2, TNFRSF10D RANK, TRANCE-R, ODFR, TNFRSF11A TWEAK-R, FGFinducible 14, TNFRSF12A TACI, TNFRSF13B BAFFR, TR13C, TNFRSF13C BCMA, TNFRSF17 TNFRSF14, HVEM NGFR, TNFRSF16 BTLA B7DC, PD-L2, PDCD1L2, PDCD1LG2 B7-H1, PD-L1, PDCD1LG1 B7-H2, ICOSL, B7RP1, GL50, ICOSLG B7-H3 BT3.1, BTF5, BTN3A1 ICOS, AILIM PD1, SLEB2, PDC1 UPARAP, MRC2 TLR1 TLR2 TLR3 TLR4 TLR6 TLR8 TLR9 TLR10 BMPR1A, ALK3 BMPR1B, ALK6 CRTH2. GPR44 LeptinR, LEPR ART1, RT6, ART2 ART4, dombrock blood group, DOK1 ATP13 DC-SIGN-related, LSIGN, DC-SIGN2, CLEC4M CMRF35H, IRC1, IRp60 CMRF35A, LIR CMRF35L IREM1, MAIR-V MGL, HML, CLEC10A DCL1, BIMLEC BDCA2, HECL BDCA4, neuropilin 1, NRP1 LAIR1 LAIR2 FCRL1 FCRL2 FCRL3 FCRL4 FCRL5 VEGFR2, KDR EMR2 NKG2D, KLRK1 CD9P1, SMAP6, FPRP, PTGFRN EWI2, PGRL, CD81P3, KASP, IGSF8 BST2, HM1.24 CDCP1, SIMA135 CRACC, SLAMF7 8D6A, 8D6 JAM1, F11R JAM2, VE-JAM E-Cadherin, CDH1 N-Cadherin, NCAD, CDH2 EpCAM, TACSTD1 SIGLEC6 SIGLEC7, AIRM-1 SIGLEC9 FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM FGFR2, BEK, KGFR FGFR3, ACH, CEK2 FGFR4, JTK2, TKF NKp46, NCR1

20 32, 23 32 93 78-85 30-32 30-32 50 42 180 70 220-240 80 16 175 160 34 32 35

erythrocytes erythrocytes, stem cell subset erythrocytes, stem cell subset erythrocytes, stem cell subset erythrocytes, stem cell subset, fibroblasts erythrocytes erythrocytes erythrocytes erythrocytes stem cells, endothelial, epithelial T subset, monocytes, basophils, NK lymphocytes, platelets, monocytes, granulocytes, NK anaplastic T cell leukemias, small intestine, testis, brain T, NK subset endothelial tissue, stromal fibroblasts epithelial, endothelial B, DC, mast, endothelial, cardiac myocytes T, DC, Bact, NK, monocytes

CD50, CD54, CD102, iC3b, fibrinogen

Endothelial Cell Antigens

CD31 (PECAM-1) CD34 CD54 CD61 CD62E (E-Selectin) CD105 (Endoglin) CD106 (VCAM-1) CD144 (VE-Cadherin) CD146 CD202b (Tie2) CD309 (FLK1)

CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 CD33

complex w/ CD21 and CD81, BCR co-receptor, B cell activation/ differentiation B, T subset B cell activation B, FDC, T subset complex w/ CD19 and CD81, BCR co-receptor B adhesion, B-mono, B-T interactions B, macrophagesact, eosinophils, FDC, platelets signal transduction B, granulocytes, T subset, epithelial B cell differentiation marker Tact, Bact, Treg, lymphoid progenitors forms high affinity IL-2 receptor with CD122 and CD132 mature thymocytes, Tact, B, macrophages, NK dipeptidyl peptidase, T costimulation medullary thymocytes, T, B subset, NK subset, T costimulation HSC most T, thymocytes, plasma T costimulation All leukocytes, fibroblasts, endothial, epithelial Associates with integrin subunits (CD49a-f, C D51) Bact, T and NK cells , Reed-Sternberg cells, anaplastic large cell lymphoma leukocytes, platelets, endothelial monocytes, granulocytes, B, platelets, macrophages myeloid progenitors, monocytes, granulocytes, DC, macrophages hematopoietic precursors, capillary endothelial, embryonic fibroblasts erythrocytes, B, monocytes, neutrophils, eosinophils, FDC, T subset platelets, monocytes, macrophages, endothelial B, B-CLL, HCL, B-NHL, Low on: T, granulocytes, monocytes, neutrophils, variable levels on majority of hematopoietic cells, high expression on plasma cells, B and Tact NK, macrophages, Langerhans cells, DC, Bact, Treg B, macrophages, FDC, endothelial, T subset platelets, megakaryocytes platelets, megakaryocytes platelets, megakaryocytes platelets, megakaryocytes platelets, megakaryocytes leukocytes, except resting B, plateletslow leukocytes, endothelial, epithelial leukocytes, endothelial, epithelial heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact all leukocytes B, Tact B, nave T, monocytes B, T subset, monocytes, macrophages, granulocytes B, T subset, NK Tact, memory T, B subset, monocytes, macrophages, granulocytes nucleated cells hematopoietic cells, epithelial, endothelial, fibroblasts new designation for CDw149, similar distribution as CD47 but dimmer all leukocytes Tact, monocytes B, monocytes, platelets, Tact, megakaryocytes B and Tlow, most adherent cell lines lymphocyte proliferation, apoptosis adhesion, signal transduction low affinity Fc receptor, B cell activation adhesion stem cell marker, adhesion adhesion, phagocytosis adhesion, phagocytosis signal transduction ecto-ADP-ribosyl cyclase, cell activation, signal transduction B cell adhesion, ecto-apyrase B differentiation/ costimulation, isotype-switching, rescues B cells from apoptosis heterodimer with CD61, platelet activation and aggregation complex w/ CD42b, c and d, platelet adhesion/ activation complex w/ CD42a, c and d, platelet adhesion/ activation complex w/ CD42a, b, d, platelet adhesion/ activation complex w/ CD42a-c inhibits adhesion adhesion, migration adhesion, migration adhesion, metastasis adhesion, metastasis adhesion, metastasis adhesion, metastasis adhesion, metastasis adhesion, metastasis adhesion, metastasis adhesion, metastasis tyrosine phosphatase, signaling exon A isoforms of CD45 exon B isoforms of CD45 exon C isoforms of CD45 isoform of CD45 lacking A, B, C exons membrane cofactor protein leukocyte adhesion, migration, activation

laminin 5 chain

C3d, CD23, EBV BPCNeuAc IgE, CD21, CD11b, CD11c IL-2 FAP, HIV Tat, collagen CD70 CD80, CD86 VCAM-1, MAdCAM-1, ECM proteins CD153 CD31, CD38 polymeric or aggregated IgG CD62L C3b, C4b collagen (I, IV, V), thrombospondin, oxidized LDL CD31, hyaluronic acid

CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120a CD120b CD121a CD121b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130

CD34+ subset, megakaryocytes, endothelial, epithelial testis, placenta, epithelial granulocytes, monocytes, platelets, endothelial monocytes, macrophages, osteoclasts, DC, monocytic progenitors monocytes, granulocytes, DC, endothelial, neutrophils, fibroblasts hematopoietic stem cells and progenitors, fibroblasts, mast epithelial cells in adult and embryo

CD11a/CD18, CD11b/ CD18, CD51, CD29, integrin 5 CD48 pleiotrophin, midkine

PECAM-1, endocam, 130-140 GPIIa FcRII 40 p67, Siglec-3, My9 My10, Mucosialin, gp105-120 CR1, C3b/C4bR, Immune adherence receptor GPIV, GPIIIb, OKM5 antigen, PASIV gp52-40, Tspan-26 T10, ADP-ribosyl cyclase ENTPD-1, gp80, EC3.6.1.5 TNFRSF5, Bp50 gpIIb, ITGA2B GPIX, GP9 GPIba GPIbb GPV Leukosialin, sialophorin, gpL115 H-CAM, Pgp-1, Hermes antigen, ECMRIII H-CAM, Pgp-1, Hermes antigen, ECMRIII CD44 variant 1-10 CD44 variant 1-10 67 105-120 250 88 40-52 45 78 48 22, 125 22 145 24 82 115-135 80-95 80-95

Granulocyte Antigens
CD10 CD11b CD11c CD14low CD15 CD16b CD31 CD33 CD66b CD88 CD181 (CXCR1) CD182 (CXCR2) CD217 (IL-17RA)

CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42a CD42b

IL-6R, gp130, IL6ST 130 CFS2RB, IL-3R common Common , IL2RG AC133, prominin-like 1, PROM1 OX-40, TNFRSF4 Flt3/Flk-2 MSP-R, RON, MST1R 4-1BB, TNFRSF9 Syndecan-1 95-120 64 120 48-50 130-150 180 30 80-150 228 PDGFRA, PDGFR PDGFRB, PDGFR Thrombomodulin, THBD Tissue Factor, TF, F3 ACE VE-Cadherin, Cadherin-5 MUC18, S-endo, MCAM, Mel-CAM Neurothelin, basoglin, EMMPRIN, BSG HPTP-eta, PTPRJ, DEP-1 SLAM, IPO-3 PETA-3, Tspan-24, RAPH CTLA-4 CD30L, TNFSF8 CD40L, gp39, TRAP, TNFSF5 PVR, NECL5 ADAM8, MS2 TACE/ADAM 17 ADAM10 BST-1 KIR2DL1, p58.1 KIR2DL2, p58.2 KIR2DL3, p58.2 KIR2DL4 KIR3DL1 KIR2DL5A KIR2DS5 KIR2DS1 KIR2DS4 KIR2DS2 KIR3DL2 KIR3DL3 NKG2A, KLRC1 NKG2C, KLRC2 BY55,NK1, NK28 NKR-P1A, KLRB1 PSGL-1 PEN-5 M130, GHI/61, D11, RM3/1 MGC-24, MUC-24 AD2, gp37 ALCAM DDR1 RHAMM 43 40 27 40 120 110-140 130 80 42 105 120 84-88 50 35, 58 50 70 180 180 100 45 170 130 90, 110 113-118 28 240-260 75-95 32 33 40 32-39 80-90 69 100 98 42-45 50-58 50-58 50-58 41 70 50-58

CD154 vitronectin, fibrinogen, fibronectin, vWF, thrombospondin vWF and thrombin vWF and thrombin vWF and thrombin vWF and thrombin CD54, hyaluronic acid hyaluronin, osteopontin, fibronectin hyaluronin, osteopontin, fibronectin hyaluronin hyaluronin hyaluronin hyaluronin hyaluronin hyaluronin hyaluronin hyaluronin

CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD139 CD140a CD140b CD141 CD142 CD143 CD144 CDw145 CD146 CD147 CD148 CD150 CD151 CD152 CD153 CD154 CD155 CD156a CD156b CD156c

Macrophage/Monocyte Antigens
CD11a CD11b CD11c CD14 CD15low CD33 CD64 CD68 CD80 CD85 (ILT) family CD86 CD105 (Endoglin) CD115 CD163 CD195 (CCR5) CD282 (TLR2) CD284 (TLR4)

CD42c CD42d CD43 CD44 CD44std CD44var (v4) CD44var (v10)

macrophages, monocytes, B, T, NK, neutrophils, endothelial, epithelial, fibroblasts nucleated cells mediates pro-inflammatory cellular responses, programmed cell death and anti-viral activity nucleated cells mediates pro-inflammatory cellular responses, programmed cell death and anti-viral activity T cells, thymocytes,chondrocytes, synovial IL-1 signaling cells, hepatocytes, endothelial, keratinocytes B cells, monocytes, macrophages, neutrophils IL-1 signaling, decoy receptor for IL-1b NK, T, B, monocytes, macrophages associates with CD25, CD132 and CD215, signal transduction lymphocyte subset, basophils, hematopoietic associates with CD131 progenitors, macrophages, DC, megakaryocytes mature T and B, hematopoietic precursors, associates with CD132 and IL-13R, T cell growth/ fibroblast, epithelial, endothelial differentiation eosinophils, basophils, B, mast associates with CD131 Bact, T, monocytes, fibroblasts associates with CD130 T, B cell precursors, thymocytes associates with CD132, B and T cell development T, B, erythroid and myeloid precursors, mast, associates with CD132, B and T cell development macrophages, epithelial Bact, plasma cells, T, monocytes, endothelial associates with CD126, LIF-R, OSMRb, signal transduction monocytes, granulocytes, early B associates with CD123, CD125, CD116, signal transduction T, B, NK, monocytes, macrophages, associates with CD25, CD122, CD124, CD127, CD129, granulocytes and CD215, signal transduction HSC and progenitors, epithelial and endothelial precursors Tact, Treg T cell activation, differentiation, apoptosis myelomonocytic, primitive B progenitors receptor tyrosine kinase, early lymph development epithelial , CNS, PNS, hematopoietic subset migration, morphological change and proliferation of different target cells Tact, Bact plasma cells, pre-B, basolateral surface of epithium, neurons B, monocytes, granulocytes, erythrocyteslow, FDC mesenchymal, fibroblasts, glial cells, monocytes, endothelial mesenchymal, endothelial, stromal cells monocytes, neutrophils, endothelial, smooth muscle cells monocytes, endothelial, keratinocytes, epithelial endothelial, epithelial, neurons, fibroblasts, macrophagesact endothelial, stem cells endothelial endothelial, melanoma, FDC, Tact T costimulation cell morphology, adhesion and migration

TCR complex subunit, coupling of antigen recognition to signaling tumor angiogenesis associates with angiotensin II and cholecystokinin-8 T costimulation CD134 CD261, CD262, CD263, CD264, OPG osteoclast differentiation, enhances DC stimulation of CD265,OPG nave T proliferation induces apoptosis, promotes angiogenesis CD266 CD267, CD269 apoptosis

lymph node and BM stroma, Tact, osteoblasts, osteoclasts 18, 30-35 endothelial cells, smooth muscle, fibroblasts 16 31 28 57 60 65 35 97 14 32 25 20 30 45 33 25 33 60 40-45 56 55-60 55 180 90 90 100 100 90 110 120 90 57 57 55-70 132 37 38 52 45 60 23 45 60 38 19-28 38 130 32-40 16 55-105

monocytes, macrophages, leukocytes,myeloid B proliferation, apoptosis DC, monocytesact, B, macrophages, myeloid cells Tact, monocytesact Tact leukocytes T,B, NK, macrophages, monocytes, granulocytes T,B, NK, macrophages, monocytes, granulocytes broad expression, DC, osteoclasts vascular endothelial and epithelial cells, keratinocyte B, myeloma B, T subset mature B (membrane and perinuclear), plasma cells T, monocytes, DC neurons (Schwann cells), BM mesenchymal cells, DC subset, monocytes Tact, Bact , Th1, macrophages, DC DC subset, monocytes, macrophages macrophages, epithelial, DC, NK, monocytesact, Tact, Bact endothelial, macrophages, DC, T, B, monocytesact epithelial, NK, monocytesact, B, T, DC subset B, T, NK, DC, monocytes, endothelial, stem cell subsets Tact, Th2 Tact , Bact, thymocytes chondrocytes, osteoclasts, osteocytes, endothelial, macrophages DC, keratinocytes, macrophages, monocytes, neutrophils monocytes, macrophages, granulocytes, keratinocytes, DC, neutrophils fibroblasts, epithelial, myeloid DC (may be intracellular) monocytes, DC, macrophages, granulocytes, endothelial, Tact macrophages, monocytes, epithelial, endothelial leukocytes, monocytes, DC pDC (intracellular), Bact pDC, Bact bone progenitor cells, chondrocytes, epithelial epithelial, mesenchymaland bone progenitors Th2, eosinophils, basophils hematopoieticcells heart and skeletal muscle, T subset, NK, neutrophils, epithelial erythroid, T, monocytesact all leukocytes endothelial subset T subset, B, monocytes, mast, granulocytes, NK, neutrophils, DC monocytes, neutrophils, NK, DC, B and T subsets monocytes, macrophages, neutrophils myeloid immature DC, macrophages macrophages, granulocytes, monocytes, DC pDC, neutrophils, macrophages neurons, Treg, DC, endothelial NK, B, T, monocytes, DC monocytes, T B subset, B lymphoma B subset B subset B subset B subset

B cell growth factor and costimulator of Ig production CD267, CD268, CD269 B cell survival and activation induces apoptosis via FADD and caspase 8 induces apoptosis via FADD and caspase 8 inhibits CD253 mediated apoptosis decoy receptor, inhibits apoptosis osteoclastogenesis, T-DC interactions cell-matrix interactions and endothelial growth and migration involved in the stimulation of T cell function mature B survival B survival and proliferation stimulatory and inhibitory signaling mediates cell survival as well as cell death attenuation of T-cell activation costimulation or suppression of T proliferation costimulation or suppression for T cells costimulation, cytokine production regulation of T cell-mediated immune response regulator of T cell activation and function T costimulation CD275 associated with apoptotic programmed cell death and CD273, CD274 the inhibition of T cell proliferation collagen matrix remodeling and endocytic recycling collagen pathogen recognition, activation of innate immunity, associates with CD282 pathogen recognition, activation of innate immunity, associates with CD281 and CD286 pathogen recognition, activation of innate immunity innate immune response to bacterial LPS, associates with MD2 and CD14 innate immune response to bacterial LPS, associates with MD2 and CD14 pathogen recognition, activation of innate immunity pathogen recognition, activation of innate immunity pathogen recognition, activation of innate immunity bone development bone development stimulatory effects on Th2, allergic inflammation adipose metabolism, immune dysfunction in obesity ADP ribosylation of target proteins, associates with PDGF, integrins and defensin ADP ribosylation of target proteins transport sodium and potassium ions across membrane pathogen recognition receptor proposed inhibitory receptor proposed activating receptor proposed activating receptor inhibitory receptor uptake of glycosylated antigens fusion protein in Hodgkins lymphoma with CD205 inhibit IFN-/ production angiogenesis and cell survival, migration and invasion semaphorin-3A, vascular endothelial growth factor A, plexin-1 inhibitor of cell function soluble, mucosal tolerance, thought to inhibit cellular activation and inflammation regulating B cell activation, development and differentiation may have a regulatory role in normal and neoplastic B cell development may play a role in regulation of the immune system may function as an inhibitor of the B cell receptor signaling may be involved in B cell development and differentiation regulates adhesion and cell signaling, angiogenesis VEGF chondroitin sulfate, glycosaminoglycan, CD55 MICA, MICB, ULBP1, ULBP2, ULBP3 lipoprotein, lipopeptide lipoproteins and glycans dsRNA LPS LPS bacterial diacyllipopeptides CpG-DNA BMP-2, BMP-4 BMP-7, GDF5 binds prostaglandin D2 leptin CD270, LTR CD253 CD253 CD253 CD253 CD254 CD255 CD256, CD257 CD257 CD256, CD257 CD258, CD272, HSV-1, HSV-2 NGF, BDNF, NT-3, NT-4 CD270 CD279 CD279 CD278

CD252 FLT3 ligand MSP, HGF1 4-1BB ligand ECM

tyrosine kinase receptor tyrosine kinase receptor initiation of protein C anticoagulant signal initiator of clotting angiotensin converting enzyme adhesion, endothelium biology adhesion

PDGF-A, PDGF-B, PDGF-C PDGF-B thrombin factor VIIa angiotensin I, bradykinin CD144, -catenin

CD44var (v7-v8) CD44 variant 1-10 CD44 (v6) CD44 (v3) CD44 (v6) CD44 (v5) CD44 (v7) CD44 variant 1-10 CD44 variant 1-10 CD44 variant 1-10 CD44 variant 1-10 CD44 variant 1-10 LCA, PTPRC, T200 B220 180-240 220 205-220 190-220 190-220 180 MCP IAP, neurophilin MEM-133 Blast-1, Hulym3 VLA-1, Integrin 1, ITGA1 VLA-2, Integrin 2, ITGA2 VLA-3, Integrin 3, ITGA3 VLA-4, Integrin 4, ITGA4 VLA-5, Integrin 5, ITGA5 VLA-6, Integrin 6, ITGA6 ICAM-3 56-76 45-60 120 45 210 165 125 150 25, 135 125 110-120

leukocytes, erythrocytes, platelets, endothelial adhesion granulocytes, monocytes, DC, Tact T subset (high upon activation), B, DC, endothelial endothelial, megakaryocytes, platelets, epithelial Tact and B Tact, macrophages, netrophils, B Tact, B, macrophages, DC monocytes, macrophages neutrophils, monocytes, granulocytes T, neutrophils, monocytes, macrophages, DC, enothelial neural precursors, fibroblasts, leukocytes tyrosine phosphatase R Type III, signaling costimulation, proliferation, Ig production, measles virus receptor, T and B cell activation cell adhesion, associates with integrins negative regulation of T cell activation T costimulation B and DC costimulation

CD62E

CD281 CD282 CD283

Megakaryocyte/Platelet Antigens
CD9 CD31 (PECAM-1) CD41 CD42b CD51 CD61 CD62P (P-Selectin)

CD45 CD45R CD45RA CD45RB CD45RC CD45R0 CD46 CD47 CD47R CD48 CD49a CD49b CD49c

CD150

CD284 CD286

CD22 C3b, C4b, measles virus receptor thrombospondin

CD80, CD86 CD30 CD40 polio virus, CD96

CD288 CD289 CD290 CD292 CD293 CD294 CD295 CD296 CD297

cell adhesion CD2 (low affinity), CD244 adhesion, signal transduction, heterodimer with CD29 collagen, laminin 1 adhesion, signal transduction, heterodimer with CD29 collagen, laminin

CD157 CD158a CD158b1 CD158b2 CD158d CD158e CD158f CD158g CD158h CD158i CD158j CD158k CD158z CD159a CD159c CD160 CD161 CD162 CD162R CD163 CD164 CD165 CD166 CD167a CD168 CD169 CD170 CD171

NK Cell Antigens
CD11b CD16a CD25 CD56 CD57 CD69 CD94 CD122 CD158 (KIR) family CD161 CD244 CD314 (NKG2D) CD319 (CRACC) CD328 (Siglec-7)

CD49d CD49e CD49f CD50 CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD60a CD60b CD60c CD61 CD62E CD62L CD62P CD63 CD64 CD65 CD65s CD66a CD66b

adhesion, signal transduction, heterodimer with CD29 collagen, laminin, fibronectin T, B, NK, thymocytes, monocytes, eosinophils, adhesion, signal transduction, heterodimer with CD29 CD106, fibronectin, mast, DC or ITGB7 (integrin 7) MAdCAM-1 thymocytes, T, monocytes, platelets, and Bact adhesion, signal transduction, heterodimer with CD29 fibronectin memory T, thymocytes, monocytes, platelets, megakaryocytes, epithelial hematopoietic, endothelial, epidermal Langerhans plateletslow, endothelial, osteoblasts, melanomas thymocytes, lymphocytes, monocytes, macrophages leukocytes, DC, osteoblasts, osteoclasts endothelial, monocytes, lymphocytesact adhesion, signal transduction, heterodimer with CD29 laminin, merosin or CD104 adhesion, costimulation CD11a/CD18, integrin d/ CD18, CD209 adhesion, signal transduction, heterodimer with CD29, vitronectin, CD61, ITGB5, ITGB6, or ITGB8 vWF, fibrinogen, thrombospondin unknown signal transduction adhesion, signal transduction CD11a/CD18, CD11b/CD18, rhinovirus C3b, C4b, CD97, echovirus, coxsackie B chondroitin sulphate proteoglycans CD62L, CD62P CD2 C8, C9

Vitronectin receptor, 24, 125 ITGAV CAMPATH-1, HES MCR, Tspan-25 ICAM-1 DAF 21-28 35-42 90-110 60-70

hematopoietic, endothelial, soluble in plasma complement regulation NK, T subset, neurons, some large granular lymphocyte leukemias, myeloid leukemias NK subset, T subset, neural tissue all nucleated cells all nucleated cells T subset, platelets, thymic epithelium, astrocytes T subset, Bact T subset platelets, megakaryocytes, macrophages, endothelial activated endothelium B, nave T, memory T, monocytes, granulocytes, NK, thymocytes plateletsact, endothelial, megakaryocytes plateletsact, monocytes, macrophages, endothelial monocytes, macrophages, DC granulocytes, monocyte subset, myeloid leukemias granulocytes, monocytes, myeloid leukemias granulocytes, epithelial granulocytes granulocytes, epithelial granulocytes epithelial placental syncytiotrophoblasts, fetal liver monocytes, macrophages, neutrophils, basophils, mast, DC, myeloid progenitors, liver, B subset Tact, B, NK and granulocytes, thymocytes, platelets, Langerhans Bact and Tact, NK adhesion adhesion adhesion regulates complement-mediated cell lysis costimulation

NCAM, Leu-19, NKH1 175-220 HNK-1, Leu-7 LFA-3 Protectin, MIRL, MACIF, P-18 GD3 9-O-acetyl GD3 7-O-acetyl GD3 GPIIIa, Integrin 3 E-selectin, ELAM-1 110 55-70 19 90-120

Stem Cell Antigens

CD34 CD38low CD90 CD105 (Endoglin) CD110 CD111 CD117 (c-Kit) CD133 CD135 (Flt3) CD184 (CXCR4) CD202b (Tie1) CD243 (MDR1) CD309 (FLK1) CD338 (ABCG2)

105

97, 107115 L-selectin, LECAM-1, 74, 95 Leu-8, LAM-1 P-selectin, PADGEM 140 LIMP, LAMP-3, ME491 FcRI, FcRI VIM2 53 72

adhesion, signal transduction, heterodimer with CD41 vitronectin, vWF, or CD51 fibrinogen and fibronectin adhesion, cell rolling, metastasis binds CD15s, CD162 adhesion, leukocyte homing and rolling adhesion, leukocyte rolling, platelet-neutrophil and platelet-mono interactions lysosomal membrane protein, expressed on cell surface after activation phagocytosis and ADCC CD15s,CD34, CD57, CD162, GlyCAM-1, MAdCAM-1 CD15s, CD162

cell migration and adhesion, associates with CD113 leukocyte extravasation, adhesion cleaves membrane proteins (TNF, TGF) to generate soluble forms proteolytic cleavage of cell-surface molecules including Notch, TNF-, APP and ephrin-A2 granulocytes, monocytes, B progenitors, ADP-ribosyl-cyclic ADP-ribose hydrolase activities, endothelial pre-B cell growth NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset activation of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset activation of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset activation of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset activation of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor T subset, NK associates with CD94, inhibition of NK cell cytolytic activity T subset, NK associates with CD94, inhibition of NK cell cytolytic activity NK subset, T subset costimulation of CD8 T T subset, NK NK cell-mediated cytotoxicity monocytes, granulocytes, most lymphocytes, leukocyte adhesion, rolling HSC NK subset homing receptor for NK cells monocytes, macrophages hemoglobin/haptoglobin scavenger receptor HSC, embryonal tissue, monocytes, stromal cells lymphocytes, thymocytes, platelets, epithelial neurons, monocytes, epithelial, fibroblasts, Tact epithelial, DC myelomonocytic lineage and DC putative role in intracellular adhesion, hematopoietic progenitor cell-stromal cell interaction adhesion, thymocyte-thymic epithelium interaction migration, adhesion tyrosine kinase, adhesion associates with CD44, adhesion, tumor migration, metastasis adhesion, cell-cell and cell-matrix interactions adhesion

HLA-C HLA-C HLA-C HLA-G HLA-B HLA-B

CD298 CD299 CD300a CD300c CD300e CD300f CD301 CD302 CD303 CD304 CD305 CD306 CD307a CD307b

CD50, HIV-1 gp120

HLA-C HLA-C HLA-C

HLA-E HLA-E HLA-C CD62P, CD62E, CD62L CD62L

CD307c CD307d CD307e CD309 CD312 CD314 CD315

230 90 42 135 63-75 30-36 135 66 30 35 43 120 140 35-40 49 75 50 30 115-135 115 110 46

CD6 collagen CD43, CD206, CD227 2,3- and 2,6-linked sialic acid CD9, CD24, CD56, CD142, CD166, CD171, neurocan, phosphocan, laminin CD47

CD316 CD317 CD318 CD319 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331

endothelial, megakaryocytes, platelets, primitive stem cell subsets monocytes, macrophages, monocyte-derived cell adhesion and migration for phagocytosis DC NK, T subset activates cytolysis and cytokine production, costimulation B subset, monocytesact, endothelial, epithelial associates with CD81 and CD9, regulates cell motility and polarity B, T, NK associates with CD81 and CD9 B cell growth and development cell adhesion with ECM regulates T and NK cells development of germinal centers and proliferation of B cells endothelial, epithelial, erythrocytes, platelets, formation of tight junctions neutrophils, monocytes, lymphocytes HEV, endothelial, B, monocytes, T subsets cell adhesion, lymphocyte homing to secondary lymphoid organs, formation of tight junctions non-neural epithelial, stem cells, cell adhesion, homotypic interaction erythroblasts, keratinocytes, trophoblasts, platelets endothelial , stem cells, muscle cells, forms a complex with catenins that is linked to the osteoblasts, neurons, BM stromal cells actin cytoskeleton epthelial cell adhesion, metastatic carcinoma cell marker placenta, spleen, B, neutrophils, granulocytes adhesion, cell-cell interactions trophoblasts may inhibit regulation of T cell and NK cell activation resting and activated NK, granulocytes, monocytes, T neutrophils, monocytes negative regulation of immune responses fibroblasts, epithelial, endothelial fibroblasts, epithelial, mesenchymal cells fibroblasts, epithelial lymphocytes, macrophages, fibroblasts, skeletal muscle, epithelial NK NK NK stem cell subset (side population) BM stroma, epithelial BM, mesenchymal stem, tumor adult kidney, lung, brain, liver, neuronal progenitors adult and fetal brain, testis, eye, skeletal muscle, kidney, BM mesenchymal stem placenta and kidney; fetal lung and brain B, T, NK, monocytes, DC, BM stromal cells HSC (subset of CD34+), epithelial Bact and DC subset, NK FDC, germinal centers

monomeric and aggregated IgG

sialoadhesin, Siglec-1 185 Siglec-5, CD33-like2 140 L1 SIRPa, SHPS-1 SIRP1 SIRP, SIRP2 Blood group H type 2, blood group type O Lewis Y, FUT3, LeY TN antigen Sialyl-Tn TF, Thomson Friedrenreich Ag NB1, HNA-2A FasL, CD95L VPREB1, IGVPB IGLL1, IGO RP-105, LY64 CXCR1, IL-8RA CXCR2, IL-8RB CXCR3 CXCR4, fusin CXCR5, BLR1 CXCR6, BONZO CCR1, MIP-1R, RANTES-R CCR2, MCP-1-R CCR3, CKR3 CCR5 CCR6, LARC receptor, DRY6 CCR7, EBI-1 CCR8, GPRCY6, TER1 CCR9, GPR-9-6 OX-2 OX-2R EPC-R, PROCR Tie2, Tek ENPP3, PDNP3, PD-1b MSR-1, SRA DEC-205 MRC1 Langerin 200-210 110 50 45-50

tissue macrophage subset macrophage subset, neutrophils, DC, monocytes glial cells, monocytes, T subset, B, DC, neurons adhesion and migration monocytes, macrophages, granulocytes T subset, stem monocytes, granulocytes, DC T, NK, B erythrocytes, stem cell subset stem cell subset, epithelial stem cell subset erythroblasts, epithelial, endothelial stem cell subset,erythrocytes, endothelial adhesion, signaling

CD319 CD11a/CD18, reovirus PAR-3, CD49d/CD29 CD103, PS1, catenins, internalin N-Cadherin, catenins, FGFR, PS1 CD305, CD306 sialyl-Tn motifs, leptin

T Cell Antigens
CD2 CD3 CD4 CD5 CD7 CD8 CD25 CD27 CD28 CD39 CD45RA CD45RO CD62L (L-Selectin) CD69 CD73 CD101 CD127 CD134 CD137 (4-1BB) CD152 CD154 CD197 (CCR7) CD272 (BTLA) CD278 (ICOS) CD279 (PD-1)

CD66c CD66d CD66e CD66f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD75 CD75s CD77

VIM2 BGP-1, NCA-160, CEACAM1 CD67, CGM6, NCA95, CEACAM8 NCA, NCA-50/90, CEACAM6 CGM1, CEACAM3 CEA, CEACAM5 PSG1, Sp-1 Macrosialin, gp110 AIM, MLR3, VEA Ki-24, CD27L T9, TFRC Ly-32.2, Ly-19.2 NT5E Ii, invariant chain lactosamines sialylated lactosamines Gb3, Pk blood groupBLA, CTH Iga, MB1 Igb, B29 B7, B7-1, BB1 TAPA-1 R2, 4F9, C33, IA4 HB15 GR6, SLAMF5 LIR-3, ILT5, HL-9, LILRB3 ILT8, LILRA6 LIR8, LILRB5 LIR2, ILT4, MIR10, LILRB2 ILT6, LIR4, LILRA3 ILT11, LIR9, LILRA5 LIR4, ILT7 LIR7, ILT1, LILRA2 ILR6, LILRA1 LIR1, ILT2, MIR-7, LILRB1

160-180 95-100 90 35 180-200 54-72 110 28, 32 50, 70, 90, 160 95 42 69 33, 35, 41, 43 67, 85 1 33, 45 37 60 26 50-53 43 73 110

phagocytosis cell adhesion cell adhesion cell adhesion putative role in cell adhesion and signaling cell adhesion immune regulation, protects fetus from maternal immune system scavenger receptor signal transduction T and B cell costimulation

CD62E, CD66a, CD66c, CD66e CD66c CD62E, CD66a, CD66b, CD66c, CD66e CD66a, CD66c, CD66e oxidized LDL

CD172a CD172b CD172g CD173 CD174 CD175 CD175s CD176 CD177 CD178 CD179a CD179b CD180 CD181 CD182 CD183

negative regulation of RTK-coupled signaling, associates with DAP12 negative regulation of RTK-coupled signaling biosynthetic precursor of the A and B antigens putative role as co-factor to pro-coagulant y precursor for ABO antigens putative role in tumor metastasis putative role in tumor metastasis induces apoptosis B cell differentiation/signaling, associates with CD179b and IgM B cell differentiation/signaling, associates with CD179a and IgM B cell activation, LPS signaling, associates with MD-1 neutrophil chemotaxis, phospholipase D activation, repiratory burst chemotaxis of neutrophils associates with CXCL-10 (IP10), CXCL9 (Mig) and CXCL11 (I-TAC), chemotaxis of T cells cell migration and HIV entry cell migration

CD47

CD27 transferrin receptor CD5, CD100

56-62 38-42 16-18 22 95-105 39 40 40 45 45 40 39 40 45 45 45 45 50 43 45-50 48 50 150 130-150 220 205 180 40

neutrophil subset Tact, testis, neutrophil, monocytes, NK pro- and pre-B pro- and pre-B B subset, monocytes, DC neutrophils, basophils, NK, T subset, monocytes neutrophils, basophils, NK, T subset, monocytes eosinophils, Tact, NK, GM-CSF activated CD34+ progenitors B, DC, T subset, monocytes, endothelial, epithelial, granulocytes mature B, T subset, monocytes and Burkitt Lymphoma cells Tact, B subset, NK subset T, monocytes, macrophages, NK, DC, stem cell subset NKact, monocytesact, basophils, macrophages, T subset, B, endothelial eosinophils, basophils, T subset lymphocytes, monocytes, macrophages and immature DC T subset, B, DC subset, Langerhans T subset, DC subset, B T, high in Th2, NK, monocytes subset of memory T, lamina propria mononuclear cells thymocytes, endothelial, Bact, Tact myeloid lineage endothelial subset stem cells, endothelial basophils, mast, glioma cells, HSC macrophages, DC DC, thymic epithelial DC subset, macrophages Langerhans, DC

CD95

2,3- and 2,6-linked sialic acid 2,3- and 2,6-linked sialic acid cell division, regulation of cell growth and maturation, aFGF, bFGF formation of blood vessels aFGF, bFGF aFGF, bFGF aFGF, bFGF

CD332 CD333 CD334

Other Cell-Type Antigens

Epithelial Cell CD24 CD44R CD49f CD66a CD75 CD104 CD121a CD133 CD167a CD326 (EpCAM) Erythrocyte CD45 negative CD235a Fibroblast CD10 CD29 CD47 CD81 CD91 CD121a Mast Cell CD23 CD117 CD203c Neuron CD6 CD24 CD90 CD143 CD166 CD171 CD200 CD230 (Prion Protein) CD271 (NGFR) CD304 (Neuropilin) Stromal Cell CD10 CD34 CD157

CD79a CD79b CD80 CD81 CD82 CD83 CD84 CD85a CD85b CD85c CD85d Cd85e CD85f CD85g CD85h CD85i CD85j

110

55 53

110

proliferating cells, reticulocytes, erythroid iron uptake precursors B, FDC, macrophages B proliferation B subset, T subset, FDC, epithelial, endothelial ecto-5-nucleotidase, nucleoside uptake, T costimulation, lymph adhesion B, macrophages, monocytes, Langerhans, MHC class II traffic and function, maturation of DC, Tact follicular B cells B subset, epithelial lactosamines B subset, T subset a-2,6-sialylated lactosamines (previously CDw75 and CDw76) germinal center B, Burkitts lymphomashigh, apoptosis follicular lymphomaslow B component of BCR, BCR surface expression and signal transduction B component of BCR, BCR surface expression and signal transduction Bact and Tact, macrophages, DC T costimulation B, T, NK, thymocytes, DC, endothelial, complex w/ CD19, CD21 and CD225, signaling, T fibroblast, neuroblastomas, melanomas costimulation leukocytes, fibroblast, epithelial, endothelial signal transduction, associates with MHC-I, MHC-II, CD37, CD52, CD81 and 1 integrins mature DC, Langerhans, Bact and Tact dendritic cell marker thymocytes, monocytes, plateletslow, B, T putative role in adhesion, costimulation subset, tissue macrophages monocytes, macrophages, DC, granulocytes, suppression of NK cell-mediated cytotoxicity T subset NK, T subset, monocytes, macrophages, DC, B activation of NK-mediated cytotoxicity, associates with FcR NK, T subset, monocytes, macrophages, DC, B activation of NK-mediated cytotoxicity, associates with FcR NK, monocytes, macrophages suppression of NK cell-mediated cytotoxicity, associates with HLA -G, -B, -G1 B, NK activation of NK-mediated cytotoxicity, associates with FcR monocytes, neutrophils, macrophages, DC activation of NK-mediated cytotoxicity, associates with FcR pDC signaling for cytokine production monocytes activation of NK-mediated cytotoxicity, associates with FcR T subset, monocytes, macrophages, DC, B activation of NK-mediated cytotoxicity, associates with FcR DC, monocytes., T, mature B suppression of NK cell-mediated cytotoxicity, associates with HLA -A, -B, -C

IL-8 IL-8, GRO-, , and NAP-2 CXCL12, HIV-1 CXCL13

CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350 CD351 CD352 CD353 CD354 CD355 CD357 CD358 CD360 CD361 CD362 CD363

NKp44, Ly-95 44 homolog, NCR2 NKp30, Ly-117, NCR3 30 ABCG2, BCRP, Bcrp1, MXR Jagged-1, JAG1, JAGL1, hJ1 HER2/neu, ERBB2, p185HER2 FZD4, frizzled-4, Fz-4, hFz-4, FzE4 FZD9, frizzled-9, Fz-9, hFz-9 FZD10, frizzled-10, Fz-10, hFz-10 Fca/mR, FCAMR SLAMF6 SLAMF8, BLAME TREM-1 CRTAM TNFRSF18, GITR, AITR TNFRSF21 IL-21R EVI2b, EVDB Syndecan-2 S1PR1 73 135 185 59 65 65 58

Shiga toxin, verotoxin 1

CD184 CD185 CD186 CD191

CD28, CD152

CD192 CD193 CD195 CD196 CD197 CDw198 CDw199 CD200 CD200R CD201 CD202b CD203c CD204 CD205 CD206 CD207

coreceptor for SIV, strains of HIV-2 and m-tropic HIV-1 CXCL16 binds C-C type chemokines CCL4, CCL5, CCL6, CCL14, CCL15, CCL16, CCL23 alternative coreceptor for HIV-1 CCL2, CCL8, CCL16 alternative coreceptor for HIV-1 coreceptor for HIV-1 binds -defensins CCL11, CCL26, CCL7, CCL13, CCL15, CCL24, CCL5, CCL28 CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, CCL16 CCL20

viral HA, heparan sulfate proteoglycans delivers activating signals via association with DAP12/ viral HA KARAP delivers activating signals via association with CD3 membrane-associated heparan sulphate proteoglycans multi-drug resistance transporter, transport of molecules across cell membranes cell fate decisions during hematopoiesis Notch 1, Notch 2, Notch 3 member of the ERBB family of receptor tyrosine kinases activation of the Wnt/-catenin pathway activation of the Wnt/-catenin pathway activation of the Wnt/-catenin pathway

cell division, regulation of cell growth and maturation, formation of blood vessels cell division, regulation of cell growth and maturation, formation of blood vessels cell division, regulation of cell growth and maturation, formation of blood vessels delivers activating signals via association with CD3

Wnt, norrin Wnt-2, Wnt-7a. Wnt IgA, IgM

cell migration to secondary lymphoid tissue CCL19, CCL21 allergic inflammation, alternative coreceptor for HIV-1 CCL1 cell migration, alternative coreceptor for HIV-1 CCL25 inhibition of immune response inhibitory receptor, inhibits TNF secretion involved in blood coagulation receptor tyrosine kinase involved in angiogenesis ectoenzyme, binding to and clearance of extracellular nucleotides endocytosis of macromolecules endocytic receptor for antigen up-take/processing phagocytosis and pinocytosis of mannose containing molecules endocytic receptor OX-2R CD200 protein C angiopoietin-1 nucleotides LDL oligomannose-containing carbohydrates mannose-bearing glycoproteins and glycolipids

NK, T, B monocytes, macrophages, B, DC monocytes, macrophages, neutrophils, granulocytes, DC, NK NK act, CD8 Tact, B Tact, Treg hematopoietic and non-hematopoietic cells, tumor cells NK, monocytes, granulocytes, B, T widely expressed in hematopoietic cells granulocytes, monocytes, T subset, B subset NK, B, T

enhances cytokine production and proliferation associates with DAP12, mediates pro-inflammatory signaling adhesion participates in dominant immunological selftolerance apoptosis associates with CD132, activation, proliferation, development, apoptosis adhesion, migration adhesion, migration, cytoskeletal organization Necl-2 TNFSF18 APP IL-21

CD267 S1P

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Q310070h_CDAntigens

Human CD Antigens
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