Breakthrough Research on Herbal

Alternative to HRT
The publications by Natural Health International in the International Journal of
Biomedical Science of a post- and peri-menopause double-blind, placebo crossover
clinical trial confirms Femmenessence™ (Maca-GO®) as a safe, effective and natural
alternative to hormone replacement therapy (HRT).

Femmenessence™ (Maca-GO®) is a carefully selected combination of phenotypes of the herb Lepidium

peruvianum (Maca) specific for female biology. With its USDA and EU certified organic origin, the herb then
undergoes a patent pending (U.S. No. 60/819,583) non-chemical process, which delivers the commercial product
known as Femmenessence™. The end result of this patent pending process is an increased concentration and bio
availability of the entire spectrum of active key constituents found in Maca. In contrast, chemical extraction
processes that use a variety of solvents, deliver an end product with an increased concentration of only one or
selected active constituents, yet in lower overall dosages than exist in Maca-GO®. The analysis below compares
Maca-GO® to current maca extracts on the market that have concentrated levels of specific actives 10 or 4 times
that of normal maca powders.

AMINO ACIDS GLUCOSINOLATES

1. Maca-GO® (NHI) 1. Maca-GO® (NHI)

2. Arginin, standard 2. Maca 10:1 extract
3. Maca 10:1 extract 3. Capsules with Maca 10:1 extract
4. Maca 4:1 extract 4. Maca 4:1 extract
5. Prolin, standard 5. Sinigrin - standard
6. Maca-GO® (NHI) 6. Maca-GO® (NHI)

However, Maca-GO® (Femmenessence™) not only contains higher levels of these specific actives which have been
concentrated 4 or 10 times but higher levels of the full spectrum of actives found in maca. This specific phenotype
combination along with increased concentration of the entire spectrum of actives, optimized bioavailability with no
chemicals or excipients used in the process - just the pure powder - in a vegetarian capsule and all in USDA and EU
Organic, Kosher, Halal & GMP certified facilities results, in the highest quality, purest maca-based product currently
available on the market.

The efficacy of Femmenessence™ was confirmed in a double blind, placebo crossover clinical trial on peri- and post-
menopausal women, which demonstrated a statistically significant reduction in menopausal symptoms in 84% of
women. Independent reports by medical practitioners have indicated that over half of the remaining 16% could derive
improvements by adjusting the dose either up or down from the standard 2 capsules in the morning and evening.
Femmenessence™ works primarily as an adaptogen. Through its action on the hypothalamus, pituitary adrenal axis it
stimulates the body to secrete the level of hormones that are appropriate for the woman’s physiological stage of life
and are necessary for optimal health. In other words, it induces each individual woman’s body to secrete the
appropriate balance of hormones for them.

In addition, with the attainment of optimal hormone balance, it has been shown that Femmenessence™ delivers a
number of concurrent health benefits, such as significant reductions in body weight, lower levels of both blood
Triglycerides and Low Density Lipoproteins (LDL) with simultaneous increased levels of High Density Lipoproteins
(HDL) - beneficial to cardio-vascular health. Increases in gastro intestinal absorption were seen through increases in
serum calcium and iron levels. Increases in bone density were also seen in post-menopausal women.

Over 160 post-menopausal women participated in the clinical trials. They demonstrated a statistically significant
increase in E2 (P<0.001) with a statistically significant reduction in FSH levels (P<0.05). Levels of Progesterone also
increased (P>0.05). Femmenessence™ significantly alleviated symptoms (P<0.001) of menopausal discomfort such as
hot flashes, night sweats, vaginal dryness and mood swings as indicated by reductions within two months from 27 to 9
in the Kupperman’s Menopausal Index (KMI). This KMI percentage reduction in menopausal symptoms, specifically hot
flashes and mood swings, after only two months is market leading for an herbal product. This, combined with the
statistically significantly effect hormone and lipid levels, could finally offer women and doctors a natural alternative to
Hormone Replacement Therapy (HRT) or Hormone Therapy (HT).

Furthermore Natural Health International’s pharmacological study showed that when Femmenessence™ was given to
mice and rats at levels of 7.5g and up to 15g/kg body weight, there were no toxic effects determined at the range of
doses used. These studies further showed increases in estrogen levels, a distinctive (P<0.05) antidepressant-like and
sedative effect on surgically-induced “menopausal” (ovariectomized) rats, while there was no anxiolytic activity nor
disturbance of cognitive function observed in both test (ovariectomized) and control (sexually-active, non-
ovariectomized) animals.

Editorial by Dr Henry Meissner: BSc in Agricultural Sciences; MSc in Environmental Sciences; PhD in Nutritional Biochemistry. Henry’s
achievements include one of the “2000 Outstanding Intellectuals of the 21st Century" from The International Bibliographical Center, Cambridge,
England (2001), and "Five Hundred Leaders of Influence" from American Bibliographical Institute (2000). He has served on a variety of boards
throughout his career and worked extensively in the US, Europe and Asia as world renowned scientist. He has published more than 300 research &
technical publications in professional journals and 18 books. His other honors include Chairman of the Therapeutic Research Foundation, CSU-
Australia (1999). Honorary Professor, Hubei Agricultural University, China (1993); Honorary Professor, Chinese Academy of Agric. Science, Beijing,
China (1996); Visiting Professor, Nagoya University, Japan (1992) and Executive Editor, International Journal of Biomedical Science, USA (2005).

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