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I. Physical Laws Governing Blood Flow, Blood Volume, Blood Pressure, and Resistance
A. Blood Flow – the volume of blood flowing through a vessel, or organ, or the entire circulation
in a given period of time (ml/min).
1. If entire circulation, then blood flow = cardiac output
2. Fluid flow is directly related to a pressure gradient (∆P = P1 – P2); F ∝ ΔP
3. Flow is laminar through long, smooth-walled tubes.
4. Flow is turbulent through vessel constrictions, or over rough surfaces.
B. Blood Pressure – the force blood exerts against the blood vessel walls; expressed in mm Hg
C. Resistance – the opposition to flow
1. Blood flow encounters friction from vessel walls and blood cell collisions
2. Most friction encountered in peripheral circulation; therefore, aka Peripheral resistance
3. Increased resistance ------> decreased blood flow
a. Flow ∝ 1/R :(i.e., Flow is inversely proportional to resistance)
As resistance increases, flow decreases
As resistance decreases, flow increases
4. Three (3) parameters determine resistance for fluid flowing through a vessel
a. Vessel length (L) – longer vessels have greater resistance than shorter vessels
b. Fluid viscosity ( n ) – thicker fluids have greater resistance than thinner fluids
c. Vessel radius (r) – changes more often than length or viscosity
As radius increases, resistance decreases
As radius decreases, resistance decreases.
In humans, R ∝ 1/r4 ; i.e., resistance varies inversely with the fourth power
of the vessel radius (one-half the diameter).
• Reducing the radius increases the resistance 16 times and therefore
decreases flow through the vessel 16 fold
• Doubling the radius decreases resistance 16 times and therefore increases
flow through the vessel 16 fold.
Therefore, blood vessel radius becomes main determinant in resistance
• Vasoconstriction----->increased resistance-----> decreased flow
• Vasodilation--->decreased resistance-----> increased flow
D. Relationship between Flow, Pressure, and Resistance
1. Shown by the formula: F = ΔP / R , where ∆P = P1 – P2 and R is the resistance
a. When ΔP increases, flow increases and when ΔP decreases, flow decreases.
b. When R (peripheral resistance) increases, flow decreases; if R decreases, flow ↑
II. Physiology of Systemic Circulation
A. Cross-sectional area of blood vessels
1. Velocity of blood flow is affected by total cross-sectional area of the blood vessel
a. Aorta = 5 cm2 vs. Capillaries = 2500 cm2
b. Therefore, blood flow is slowest in capillaries (0.3 mm/sec) and fastest in aorta (33 cm/sec
B. Pressures and Resistances in the Various Portions of the Systemic Circulation (see Fig. 21.33)
1. Pressure of the blood falls from from 100 mm Hg in aorta to 0 mm Hg at right atrium
2. This decrease in arterial pressure in each segment of the systemic circulation is directly
proportional to the vascular resistance in the segment (aorta, arterioles, capillaries, venules,
vena cavae).
C. Capillary Exchange and Regulation of Interstitial Fluid Volume
1. Forces affecting fluid movement across capillary walls
a. Capillary hydrostatic pressure – moves fluid outward through capillary membrane
b. Interstitial fluid pressure – moves fluid inward through the capillary membrane
c. Plasma colloid osmotic pressure – causes osmosis of fluid inward through the membrane
d. Interstitial fluid colloid osmotic pressure –causes osmosis of fluid outward thru membrane
2. Net filtration pressure (NFP) = Net hydrostatic pressure – Net osmotic pressure
a. Net hydrostatic pressure = CHP – IFP ( a - b above)
b. Net osmotic pressure = PCOP - ICOP ( c – d above)
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c. Hormones EPI and NE also cause vasoconstriction; in skeletal muscle EP binds to
β-adrenergic receptors causing vasodilation
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VI. Blood Flow in Special Areas
A. Blood flow to the skeletal muscles
1. Skeletal arterioles have high vascular resistance due to alpha-adrenergic sympa-
thetic stimulation. Produces relatively low blood flow
2. Sympathetic cholinergic fibers stimulate vasodilation as part of fight-or-flight
3. Stimulation of beta-adrenergic fibers by hormone epinephrine also vasodilates
4. Increased blood flow during exercise due largely to intrinsic metabolic control
a. Latter may increase blood flow to 85% of total blood flow during exercise
B. Blood flow to the Brain
1. Cerebral blood flow NOT normally influenced by sympathetic nerve activity
a. Becomes active only when MAP rises to about 200 mmHg
2. Regulated almost exclusively by local control mechanisms (‘autoregulation”)
a. Myogenic regulation
• ↓ BP → Vasodilation and ↑ BP → Vasoconstriction (Maintains constant flo
b. Metabolic regulation
• ↑ Carbon dioxide (due to hypoventilation) → Vasodilation (and vice versa
C. Blood flow to the heart
1. Coronary arterioles contain both alpha and beta adrenergic receptors which
promote vasoconstriction and vasodilation, respectively
2. Most vasodilation is due to intrinsic metabolic control