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KEYSTONE SYMPOSIA

20122013 Conference Series


www.keystonesymposia.org
Visit www.keystonesymposia.org/meetings or call 1.800.253.0685 or 1.970.262.1230 for the most current information and to register.
The 20122013 KeYSTONe SYMPOSIA CONfereNCe SerIeS AT A GlANCe
September 2012
Pulmonary Vascular Disease and Right Ventricular Dysfunction:
Current Concepts and Future Therapies (S1), Monterey, CA, USA #KSPVD
October 2012
Aging and Diseases of Aging (S2), Tokyo, Japan #KSaging
December 2012
Immunological Mechanisms of Vaccination (S3), Ottawa, ON, Canada
#KSvaccine
January 2013
Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1)
joint with Pathogenic Processes in Asthma and COPD (J2), Santa fe, NM, USA
#KSimmunity / #KSlung
Multiple Sclerosis (A1), Big Sky, MT, USA #KSMS
New Frontiers in Cardiovascular Genetics Beyond GWAS (A2), Tahoe City, CA,
USA #KScardio
Frontiers of NMR in Biology (A3), Snowbird, Utah, USA #KSNMr
Hematopoiesis (A4), Steamboat Springs, CO, USA #KShema
Emerging Topics in Immune System Plasticity: Cellular Networks, Metabolic
Control and Regeneration (A5), Santa fe, NM, USA #KSimmunity
Plant Abiotic Stress and Sustainable Agriculture: Translating Basic
Understanding to Food Production (A6), Taos, NM, USA #KSplant
Noncoding RNAs in Development and Cancer (A7), Vancouver, BC, Canada
#KSncrNA
Malaria (A8), New Orleans, lA, USA #KSmalaria
Metabolic Control of Infammation and Immunity (A9), Breckenridge, CO,
USA #KSimmunity
Antibodies as Drugs (J3) joint with Cancer Immunology and Immunotherapy
(J4), Vancouver, BC, Canada #KSdrug / #KScancer
Adipose Tissue Biology (J5) joint with Diabetes New Insights into Mechanism
of Disease and its Treatment (J6), Keystone, CO, USA #KSadipose / #KSdiabetes
February 2013
Mitochondria, Metabolism and Myocardial Function Basic Advances
to Translational Studies (B1), Keystone, CO, USA #KSmitochondria
Neurogenesis (J7) joint with New Frontiers in Neurodegenerative Disease
Research (J8), Santa fe, NM, USA #KSneuro
Lung Development, Cancer and Disease (B2), Taos, NM, USA #KSlung
The Gut Microbiome: The Effector/Regulatory Immune Network (B3), Taos,
NM, USA #KSgut
B Cell Development and Function (X1) joint with HIV Vaccines (X2), Keystone,
CO, USA #KSbcell / #KShIV
Autophagy, Infammation and Immunity (B4), Montreal, QC, Canada
#KSautophagy
Nutrition, Epigenetics and Human Disease (B5), Santa fe, NM, USA #KSnutrition
Myeloid Cells: Regulation and Infammation (B6), Keystone, CO, USA
#KSmyeloid
February 2013 (continued)
Stem Cell Regulation in Homeostasis and Disease (B7), Banff, AB, Canada
#KSstemcell
PI 3-Kinase and Interplay with Other Signaling Pathways (X3) joint with
Tumor Metabolism (X4), Keystone, CO, USA #KSPI3K / #KScancer
March 2013
Structural Analysis of Supramolecular Assemblies by Hybrid Methods (C1),
Tahoe City, CA, USA #KSsupramolecular
Understanding Dendritic Cell Biology to Advance Disease Therapies (C2),
Keystone, CO, USA #KSdendritic
DNA Replication and Recombination (X5) joint with Genomic Instability
and DNA Repair (X6), Banff, AB, Canada #KSDNA
Growing to Extremes: Cell Biology and Pathology of Axons (C4), Tahoe City,
CA, USA #KSaxon
Host Response in Tuberculosis (X7) joint with Tuberculosis: Understanding
the Enemy (X8), Whistler, BC, Canada #KSTB
Precision Genome Engineering and Synthetic Biology: Designing Genomes
and Pathways (C5), Breckenridge, CO, USA #KSgenome
Neuronal Control of Appetite, Metabolism and Weight (C6), Banff, AB,
Canada #KSobesity
RNA Silencing (C7), Whistler, BC, Canada #KSrNA
Epigenetic Marks and Cancer Drugs (C8), Santa fe, NM, USA #KScancer
April 2013
Molecular Clockworks and the Regulation of Cardio-Metabolic Function (C9),
Snowbird, Utah, USA #KScardio
Immune Activation in HIV Infection: Basic Mechanisms and Clinical
Implications (D2), Breckenridge, CO, USA #KShIV
Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic
Dysfunction (D3), Alpbach, Austria #KSnuclear
Immunopathology of Type 1 Diabetes (Z1) joint with Advances in the
Knowledge and Treatment of Autoimmunity (Z2), Whistler, BC, Canada
#KSdiabetes / #KSautoimmunity
Cardiac Remodeling, Signaling, Matrix and Heart Function (D4), Snowbird,
UT, USA #KScardio
Plant Immunity: Pathways and Translation (D5), Big Sky, MT, USA #KSplant
Positive Strand RNA Viruses (D7), Boston, MA, USA #KSrNA
May 2013
The Innate Immune Response in the Pathogenesis of Infectious Disease (E1),
Ouro Preto, MG, Brazil #KSimmunity
The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells
and Cancer (E2), Monterey, CA, USA #KShippo
June 2013
Human Genomics and Personalized Medicine (E3), Stockholm, Sweden
#KSgenome
PO Box 1630
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160 US highway 6, Suite 200
Silverthorne, Colorado 80498 | USA
1.970.262.1230 | 1.800.253.0685 (US & Canada)
www.keystonesymposia.org/meetings
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WELCOME TO THE 20122013
KEYSTONE SYMPOSIA CONFERENCE SERIES
We are pleased to bring you another season of focused yet cross-disciplinary conferences on exciting,
new frontiers in the life sciences. This season gets underway in September please pay close attention
to rapidly approaching abstract, scholarship and early/discounted registration deadlines.
You will notice that, in response to attendee feedback, the keynotes for many meetings have been moved
to the moining of the iist full uay This scheuule allows you moie lexibility foi youi tiavel so that upon
arrival you can register for the meeting, settle in to your lodging, and review the program and abstract
book before the meeting starts the next morning. Precise schedules vary and are still subject to change;
as always inu the most uptouate scheuules on oui website at www.keystonesymposia.org/meetings.
NEW LOCATIONS
We aie exciteu to announce oui iistevei confeience in South Ameiica The Innate Immune Response
in the Pathogenesis of Infectious Disease which will take place in 0uio Pieto Biazil in Nay
We aie also looking foiwaiu to ietuining to Stockholm foi a seconu time foi Human Genomics and
Personalized Medicine in }une
0thei new locations in oui seiies incluue Tokyo Aging and Diseases of Aging), Montreal
Autophagy, Inlammation and Immunity anu New 0ileans Malaria). In addition, we will convene
a ulobal Bealth Seiies confeience in 0ttawa in Becembei Immunological Mechanisms of
Vaccination).
CALL FOR ABSTRACTS
Consider submitting an abstract to present during one of the sessions listed on the following pages.
Scientiic oiganizeis ieview postei abstiacts to choose piesenteis foi woikshops plenaiy sessions anu
poster sessions. Presenting your research in any part of the program is a great opportunity for feedback
and collaboration.
FINANCIAL AID
Keystone Symposia offers a variety of scholarships and travel awards to help offset registration, lodging
anu tiavel costs Thanks to many geneious uonois we weie able to awaiu moie than scholaiships
to students and postdoctoral fellows as well as travel awards to developing country investigators in our
season We uige all eligible canuiuates to ieview oui vaiious oppoitunities foi inancial aiu
on page 4 or online at www.keystonesymposia.org/inancialaid.
FOLLOW US
Follow us on Facebook and Twitter or join our e-mail list to stay abreast of the most recent
developments as we head into the new season. We encourage you to post photos, videos or anecdotes
throughout the season of your favorite conference moments on our Facebook page at facebook.com/
KeystoneSymposia. Tag us in your tweets using @KeystoneSymp, subscribe to our YouTube channel
at youtube.com/KeystoneSymposia and join our group on LinkedIn.
TABLE OF CONTENTS
Conference Index .......................... pg 3
Submitting an Abstract .................. pg 4
Scholarships and Travel Awards ....... pg 4
Registration Rates ......................... pg 5
Registration Information ................ pg 5
Travel Tips ................................... pg 6
Global Health Series ...................... pg 6
20122013 Conference Programs ..... pg 763
Financial Support .......................... pg 6465
Board of Directors and Staff ............ pg 66
Scientic Advisory Board ................ pg 67
Conference Listings by Month ......... Back Cover
20122013 KEYSTONE SYMPOSIA CONFERENCES
3
Pulmonary Vascular Disease and Right Ventricular Dysfunction:

Current Concepts and Future Therapies (S1) ..................................................................................
Monterey, CA, USA ................... Sep 1015 .............. pg 7
Aging and Diseases of Aging (S2) ........................................................................................... Tokyo, Japan .......................... Oct 2227 .............. pg 8
Immunological Mechanisms of Vaccination (S3)

.................................................................... Ottawa, ON, Canada ................. Dec 1318 .............. pg 9


Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1) joint with
Pathogenic Processes in Asthma and COPD (J2) .......................................................................... Santa Fe, NM, USA ................... Jan 1015 ........ pg 10-11
Multiple Sclerosis (A1) .......................................................................................................... Big Sky, MT, USA ..................... Jan 1116 .............pg 12
New Frontiers in Cardiovascular Genetics Beyond GWAS (A2) .....................................................Tahoe City, CA, USA ................. Jan 1318 .............pg 13
Frontiers of NMR in Biology (A3) .............................................................................................. Snowbird, UT, USA ................... Jan 1318 .............pg 14
Hematopoiesis (A4) ..................................................................................................................Steamboat Springs, CO, USA ...... Jan 1419 .............pg 15
Emerging Topics in Immune System Plasticity:
Cellular Networks, Metabolic Control and Regeneration (A5)..................................................... Santa Fe, NM, USA ................... Jan 1520 .............pg 16
Plant Abiotic Stress and Sustainable Agriculture:
Translating Basic Understanding to Food Production (A6) ......................................................... Taos, NM, USA ........................ Jan 1722 .............pg 17
Noncoding RNAs in Development and Cancer (A7) .................................................................... Vancouver, BC, Canada ............. Jan 2025 .............pg 18
Malaria (A8)

...................................................................................................................... New Orleans, LA, USA .............. Jan 2025 .............pg 19


Metabolic Control of Inammation and Immunity (A9) ............................................................ Breckenridge, CO, USA .............. Jan 2126 .............pg 20
Antibodies as Drugs (J3) joint with
Cancer Immunology and Immunotherapy (J4) ............................................................................Vancouver, BC, Canada ............. Jan 27Feb 1 .... pg 22-23
Adipose Tissue Biology (J5) joint with
Diabetes New Insights into Mechanism of Disease and its Treatment (J6)............................... Keystone, CO, USA ................... Jan 27Feb 1 .... pg 24-25
Mitochondria, Metabolism and Myocardial Function
Basic Advances to Translational Studies (B1) ........................................................................... Keystone, CO, USA ................... Feb 38 ................pg 26
Neurogenesis (J7) joint with
New Frontiers in Neurodegenerative Disease Research (J8) ...................................................... Santa Fe, NM, USA ................... Feb 38 ........... pg 28-29
Lung Development, Cancer and Disease (B2) ...................................................................................... Taos, NM, USA ........................ Feb 510 ...............pg 30
The Gut Microbiome: The Effector/Regulatory Immune Network (B3)......................................... Taos, NM, USA ........................ Feb 1015 .............pg 31
B Cell Development and Function (X1) joint with
HIV Vaccines (X2)

............................................................................................................... Keystone, CO, USA ................... Feb 1015 ........ pg 32-33


Autophagy, Inammation and Immunity (B4) .......................................................................... Montreal, QC, Canada ............... Feb 1722 .............pg 34
Nutrition, Epigenetics and Human Disease (B5).......................................................................... Santa Fe, NM, USA ................... Feb 1924 .............pg 35
Myeloid Cells: Regulation and Inammation (B6) .......................................................................Keystone, CO, USA ................... Feb 1924 .............pg 36
Stem Cell Regulation in Homeostasis and Disease (B7) ............................................................ Banff, AB, Canada ................... Feb 24Mar 1 .........pg 37
PI 3-Kinase and Interplay with Other Signaling Pathways (X3) joint with
Tumor Metabolism (X4) ......................................................................................................... Keystone, CO, USA ................... Feb 24Mar 1 .... pg 38-39
Structural Analysis of Supramolecular Assemblies by Hybrid Methods (C1) ................................ Tahoe City, CA, USA ................. Mar 37 ................pg 40
Understanding Dendritic Cell Biology to Advance Disease Therapies (C2) ................................... Keystone, CO, USA ................... Mar 38 ................pg 41
DNA Replication and Recombination (X5) joint with
Genomic Instability and DNA Repair (X6) ................................................................................ Banff, AB, Canada ................... Mar 38 ........... pg 42-43
Growing to Extremes: Cell Biology and Pathology of Axons (C4) ................................................ Tahoe City, CA, USA ................. Mar 1015 .............pg 44
Host Response in Tuberculosis (X7) joint with
Tuberculosis: Understanding the Enemy (X8)

........................................................................ Whistler, BC, Canada ................ Mar 1318 ........ pg 46-47


Precision Genome Engineering and Synthetic Biology:
Designing Genomes and Pathways (C5) ................................................................................... Breckenridge, CO, USA .............. Mar 1722 .............pg 48
Neuronal Control of Appetite, Metabolism and Weight (C6) ...................................................... Banff, AB, Canada ................... Mar 1722 .............pg 49
RNA Silencing (C7) .................................................................................................................... Whistler, BC, Canada ................ Mar 1924 .............pg 50
Epigenetic Marks and Cancer Drugs (C8) .....................................................................................Santa Fe, NM, USA ................... Mar 2025 .............pg 51
Molecular Clockworks and the Regulation of Cardio-Metabolic Function (C9) .............................. Snowbird, UT, USA ................... Apr 37 ................pg 52
Immune Activation in HIV Infection: Basic Mechanisms and Clinical Implications (D2)

............ Breckenridge, CO, USA .............. Apr 38 ................pg 54


Nuclear Receptors and Friends:
Roles in Energy Homeostasis and Metabolic Dysfunction (D3)
.........................................................
Alpbach, Austria ..................... Apr 38 ................pg 55
Immunopathology of Type 1 Diabetes (Z1) joint with
Advances in the Knowledge and Treatment of Autoimmunity (Z2) ............................................. Whistler, BC, Canada ................ Apr 49 ........... pg 56-57
Cardiac Remodeling, Signaling, Matrix and Heart Function (D4) ................................................ Snowbird, UT, USA ................... Apr 712 ...............pg 58
Plant Immunity: Pathways and Translation (D5) ......................................................................... Big Sky, MT, USA ..................... Apr 712 ...............pg 59
Positive Strand RNA Viruses (D7) .............................................................................................. Boston, MA, USA ..................... Apr 28May 3 ........pg 60
The Innate Immune Response in the Pathogenesis of Infectious Disease (E1)

.......................... Ouro Preto, MG, Brazil.............. May 1015 ............pg 61


The Hippo Tumor Suppressor Network:
From Organ Size Control to Stem Cells and Cancer (E2) .............................................................. Monterey, CA, USA ................... May 1923 ............pg 62
Human Genomics and Personalized Medicine (E3) ...................................................................... Stockholm, Sweden ................. Jun 1721 .............pg 63
GREEN TYPE INDICATES STANDALONE MEETINGS | BLUE TYPE INDICATES JOINT MEETINGS |

PART OF THE KEYSTONE SYMPOSIA GLOBAL HEALTH SERIES


SUBMITTING AN ABSTRACT
Keystone Symposia strongly encourages submission of an abstract when registering for a conference; however, abstracts are not
required for registration unless you are applying for a scholarship. Presenting your abstract during your conference poster session
gives excellent exposure to your work and the opportunity to interact with many different investigators and receive valuable feedback.
Organizers also review all submitted abstracts to select oral presenters for plenary sessions and workshops. Selections are made based
on quality and relevance to the session, and invitations are issued by Keystone Symposia. To maintain fairness of the selection process,
requests to speak will not be accepted.
Abstracts will be published in a non-accredited journal which is distributed to conference participants and also available for purchase
after the conference. If you do not submit an abstract or submit it too late for publication, you may still be able to display a poster
on-site on a space-available basis. You can view our abstract formatting guidelines online at www.keystonesymposia.org/abstracts.
Please contact us at 1.800.253.0685 (US & Canada) or 1.970.262.1230 or email us at abstracts@keystonesymposia.org if you have
additional questions about abstracts and posters that are not answered here or on our website. Please note that submission of your
abstract does not constitute registration.
ABSTRACT SUBMISSION RATES
Abstracts submitted by the early abstract deadline: 50 USD
If your abstract is accepted, the 50 USD will be applied toward
your registration payment.
Abstracts submitted after the early abstract deadline (before the
late-breaking abstract deadline): 100 USD
If your abstract is accepted, 50 USD will be applied toward your
registration payment; the remaining 50 USD is non-refundable.
SPEAKERS AND ORGANIZERS
If you are an organizer or invited speaker, please refer to correspondence from the Keystone Symposia Program Implementation
Department for registration, abstract submission, travel, lodging and other information.
SCHOLARSHIPS AND TRAVEL AWARDS
We strive to make our conferences as accessible as possible to new investigators,
including students and postdoctoral fellows, as they provide excellent networking
anu mentoiing oppoitunities Foui types of inancial assistance aie available in
addition to our discounted student registration rates (student rates are listed on the
next page):
KEYSTONE SYMPOSIA SCHOLARSHIPS These are available for students and
postdoctoral fellows; the number varies depending on funding from the National
Institutes of Health, the National Science Foundation, Keystone Symposias Future of
Science Fund and other sources. Scholarship recipients will be selected based on the
quality of science of their submitted abstracts and the relevance of the abstract to
the confeience topic Awaius aie up to 0SB in valueApply anu view ueaulines
online at www.keystonesymposia.org/scholarships.
UNDERREPRESENTED MINORITY SCHOLARSHIPS Scholarships of up to 1,200 USD are available for US citizens or permanent residents
who are graduate students or postdoctoral fellows currently enrolled in an academic program and who belong to one of the following
ethnic groups: Hispanic/Latino, Black/African American (not of Hispanic origin), American Indian/Alaska Native or Native Hawaiian/
Paciic Islanuei Foi moie infoimation visit www.keystonesymposia.org/URMscholarship.
EARLY-CAREER INVESTIGATOR TRAVEL AWARDS A limited number of these awards will be given to fund up to 1,800 USD in conference
costs for assistant professors (or the industry equivalent) from an underrepresented minority (URM) background (African-American,
LatinoBispanic Paciic Islanuei oi Native AmeiicanAlaska Native who aie 0S citizens oi peimanent iesiuents Canuiuates
must be willing to mentor a young URM investigator for one year after the conference. Please visit www.keystonesymposia.org/
EarlyCareerAward to download an application and for more information on the particular deadlines associated with these Awards.
GLOBAL HEALTH TRAVEL AWARDS Awards covering meeting registration and travel/lodging expenses are available for students,
postdoctoral fellows, investigators and clinicians originating from a nation affected by health problems of the meetings in our
ulobal BealthSeiies Piefeience will be given to inuiviuuals tiaveling fiom anu ietuining to affecteu nations oi inuiviuuals cuiiently
studying in one country but planning to return to work in an affected nation. The 20122013 Global Health Series meetings are listed
on page 6. Visit www.keystonesymposia.org/GlobalHealth to learn more.
ATTENDING A KEYSTONE SYMPOSIA CONFERENCE
4
20122013 REGISTRATION RATES
CONFERENCES IN THE US AND BRAZIL
Four-Day Programs
Early/Discounted Registration: 745 USD / 520 USD student
Regular Registration: 895 USD / 670 USD student
Three-Day Programs
Early/Discounted Registration: 695 USD / 470 USD student
Regular Registration: 845 USD / 620 USD student
CONFERENCES IN CANADA AND EUROPE
Early/Discounted Registration: 795 USD / 570 USD student
Regular Registration: 945 USD / 720 USD student
Note: Pro-rated registration rates are not available.
Registration rates include admission to plenary sessions, workshops and poster sessions; one copy of the abstract book; breakfast (in most locations
check online programs for speciics; coffee breaks; and social hours. Social hours take place before or during poster sessions and vary from light
appetizers to buffets.
Registration rates do not include lodging and transportation. Inclusion of lunch or dinner in registration rates varies by site.
REGISTERING FOR A KEYSTONE SYMPOSIA CONFERENCE
ONLINE The easiest way to register is through our secure website, with payment by credit card. If you have ever attended a Keystone
Symposia meeting, you already have an account on our site. After logging in or creating your account, you will be able to register for a
conference and submit your abstract online. You will also be able to:
Euit youi abstiact
view anu piint speakei anu postei abstiacts foi the confeiences foi which you aie iegisteieu uays befoie penuing authoi
approval) and 30 days after the conference;
view anu piint full paiticipant lists foi the confeiences foi which you aie iegisteieu
Euitupuate youi contact infoimation anu mailemail piefeiences
view anu piint invoices attenuance letteis invitation letteis anu scholaiship status
Access oui ioommate bulletin boaiu
FAX/MAIL Registration forms are available for download on our website. Fax your form to 1.970.262.1525 or mail it to Keystone
Symposia, 160 US Highway 6, Suite 200, PO Box 1630, Silverthorne, CO 80498-1630, USA. Registration form and payment must
be received by the early/discounted registration deadline in order to receive that rate.
PHONE Call our Attendee Services Department at 1.800.253.0685 (US & Canada) or 1.970.262.1230 uuiing iegulai ofice houis
7:30 a.m. to 4:00 p.m. (US Mountain Time). Please have your credit card ready.
ON-SITE You may also register on-site once the conference convenes, although there is a possibility that the conference or some of its
sessions may already be full, and you will also not be eligible for the early/discounted registration rate. On-site registrations must be
paid via credit card.
CANCELLING YOUR REGISTRATION Registrants who do not cancel according to the following guidelines will forfeit all fees.
All cancellations substitutions oi changes must be iequesteu two weeks piioi to the stait of the confeience
Registiations aie tiansfeiable to othei confeiences in the same season 0R to a colleague foi the oiiginal meeting Please see oui
website foi speciic iequiiements
You must email wiite oi fax youi iequest to Keystone Symposia
Louging anu tianspoitation must be cancelleu uiiectly with the iesoit anuoi tianspoitation company
Registiation iefunus will be piocesseu within uays
If you notify Keystone Symposia of youi cancellation at least uays piioi to the confeience stait uate you will ieceive a full
refund minus a 150 USD handling fee, a 50 USD abstract fee (if applicable) and the 50 USD fee for late abstract submission (after
the deadline) if applicable.
If you notify Keystone Symposia of youi cancellation less than uays piioi to the confeience stait uate you will not ieceive
a refund.
ARRANGE FOR LODGING AND TRANSPORTATION Make your lodging arrangements early as space is limited. Keystone Symposia has
contracted discounted conference rates with various lodging establishments; please refer to the meeting page on our website for
louging infoimation speciic to each site anu to view iesoit contact infoimation Naps anu tianspoitation tips aie also available on
our website to aid you in booking your airfare and ground transportation.
ATTENDING A KEYSTONE SYMPOSIA CONFERENCE
5
TRAVEL TIPS
FINDING LODGING All lodging forms and rates are located on our website under the Lodging/Hotels tab on the meeting page or in
the My Account portal once you login to our site. Keystone Symposia is not responsible for lodging arrangements; however, we have
negotiated special group rates and will endeavor to help you resolve related problems you may have.
Please note the following:
Special gioup iates aie typically a package ueal foi the uuiation of the confeience ive nights foi fouiuay confeiences anu
four nights for three-day conferences). If you choose not to stay for all the nights of the package, you will still have to pay the full
package price. If you know you cannot attend the entire conference, your costs may be less by securing a daily rate directly with
the lodging establishment. Identify yourself as part of Keystone Symposia when you reserve your lodging.
Some sitebaseu activity uiscounts may be available to attenuees anu theii guests Such activities aie often weatheiuepenuent
and are not guaranteed. Please call the resort or hotel with questions.
To save on louging expenses consiuei shaiing a ioom visit oui ioommate bulletin boaiu unuei the FAQ tab on oui home page
to inu a ioommate
CANCELLING LODGING Lodging and transportation must be cancelled directly with the resort and/or transportation company.
Cancellation policies vaiy contact youi speciic hotel foi uetails
OBTAINING A CAR RENTAL DISCOUNT Visit our website or contact Avis directly at 1.800.331.1600 (in US & Canada) and reference
the Avis Worldwide Discount (AWD) code T487899. Reservations may also be made online at www.avis.com by entering the same
AWD code under rates and discounts.
PASSPORT AND VISA GUIDELINES Due to the constantly changing nature of travel, we urge attendees to research their own travel
speciications incluuing passpoit anu visa iequiiements uocumentation foi ieentiy into theii countiy of iesiuence anu any othei
iuentiication neeueu Please allow suficient time in auvance of the meeting foi the piocessing of such uocumentation
ADDITIONAL TRAVEL SUGGESTIONS Due to limited ground transportation opportunities at many airports, we recommend that your
light is scheuuleu to aiiive by pm anu to uepait no eailiei than am If aiiiving outsiue of these times please coniim youi
ground transportation prior to booking your airfare. Please note all suggested arrival dates on the meeting pages in this catalog.
Book all giounu tianspoitation in auvance While at the confeience ieconiim youi ietuin ieseivations Infoimation iegaiuing giounu
transportation companies is listed on our website.
Tiavel anu louging infoimation is pioviueu as a couitesy Keystone Symposia has no afiliation with the pioviueis
ATTENDING A KEYSTONE SYMPOSIA CONFERENCE
20122013 GLOBAL HEALTH SERIES Breaking the Cycle of Infectious Disease
6
The Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation, aims to help break the cycle of
infectious uisease thiough meetings on uiffeient uisease topics Keystone Symposia offeis inancial aiu in the foim of ulobal Bealth
Travel Awards to individuals from affected nations, or individuals currently studying in one country but planning to return to work
in an affected nation. Visit www.keystonesymposia.org/GlobalHealth for more information about these Travel Awards including
eligibility and applications.
The 2012-2013 Global Health Series meetings are:
IMMUNOLOGICAL MECHANISMS OF VACCINATION (page 9) Global Health Travel Award Application Deadline: July 17, 2012
MALARIA (page 19) Global Health Travel Award* Application Deadline: August 21, 2012
*Travel award funding provided by Medicines for Malaria Venture Ian Bathurst Global Health Travel Awards in addition to the Bill & Melinda Gates Foundation
HIV VACCINES (page 33) Global Health Travel Award Application Deadline: September 11, 2012
TUBERCULOSIS: UNDERSTANDING THE ENEMY (page 47) Global Health Travel Award Application Deadline: October 16, 2012
IMMUNE ACTIVATION IN HIV INFECTION: BASIC MECHANISMS AND CLINICAL IMPLICATIONS (page 54) Global Health Travel Award
Application Deadline: November 6, 2012
THE INNATE IMMUNE RESPONSE IN THE PATHOGENESIS OF INFECTIOUS DISEASE (page 61) Global Health Travel Award Application
Deadline: December 11, 2012
PULMONARY VASCULAR DISEASE
AND RIGHT VENTRICULAR DYSFUNCTION:
CURRENT CONCEPTS AND FUTURE THERAPIES
SEPTEMBER 1015, 2012
PORTOLA HOTEL & SPA, MONTEREY, CALIFORNIA, USA
(venue information on page 21)
You can still register for this meeting through
September 10, 2012. To inquire about submitting a
late-breaking abstract, please contact our ofce:
abstracts@keystonesymposia.org, 1.800.253.0685
(US & Canada) or 1.970.262.1230.
WWW.KEYSTONESYMPOSIA.ORG/12S1
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/12S1.
MONDAY, SEPTEMBER 10: ARRIVAL & REGISTRATION
TUESDAY, SEPTEMBER 11
Keynote Address
Stefanie Dimmeler, University of Frankfurt, Germany
The Role of Stem Cells in Angiogenesis and Vascular Repair
The Role of Stem Cells, Progenitor and Differentiated Blood Cells
in Pulmonary Vascular Disease and Repair
Duncan Stewart*, Ottawa Hospital Research Institute, Canada
Stella Kourembanas, Childrens Hospital Boston, Harvard Medical School, USA
Role of Bone Marrow Stromal Cells in the Repair of Chronic Lung
and Pulmonary Vascular Disease
Margaret R. MacLean, University of Glasgow, UK
Platelet Function, Serotonin and Pulmonary Vascular Disease
Paul Hassoun, Johns Hopkins University, USA
Cross-Talk between Macrophages, Granulocytes and Vascular Cells
in Pulmonary Arterial Hypertension
Duncan Stewart, Ottawa Hospital Research Institute, Canada
Progenitor Cell Transplantation and Gene Therapy
for Pulmonary Arterial Hypertension
Short Talk Chosen from Abstracts
Workshop 1: How to Translate Basic Research Findings into Improvement
of Patient Care The Role of Industry
Daniel Burkhoff, Columbia University, USA
New Devices for PH-Noninvasive Monitoring of Cardiac Output and RV Assist Devices
Matthew Thomas, Novartis Institutes for BioMedical Research, UK
Anti-Remodeling Therapies for Pulmonary Arterial Hypertension:
Challenges for Drug Discovery
Stuart Rich*, University of Chicago Medical Center, USA (panelist)
Timothy M. Moore, NHLBI, National Institutes of Health, USA (panelist)
Growth Factors, TGF-/BMP Signaling and Pulmonary Vascular Disease
Georg Hansmann*, Childrens Hospital Boston, Harvard Medical School, USA
Paul Hassoun*, Johns Hopkins University, USA
Marc Humbert, Hpital Antoine-Bclre, AP-HP, France
New Insights into the Role of Cytokines, Chemokines and Growth Factors
in Pulmonary Arterial Hypertension
Kenneth D. Bloch, Massachusetts General Hospital, USA
Role of BMPR-2 and BMP Signaling in PAH Lessons from Murine Models
Patricia Thistlethwaite, University of California, San Diego, USA
Notch Signaling in Pulmonary Vascular Disease
Short Talk Chosen from Abstracts
WEDNESDAY, SEPTEMBER 12
Metabolic Regulators in Pulmonary Vascular Disease
Stephen L. Archer*, University of Chicago Medical Center, USA
Peter F. Carmeliet, University of Leuven, Belgium
Vascular Metabolomics
Georg Hansmann, Childrens Hospital Boston, Harvard Medical School, USA
The Protective Role of PPAR in Pulmonary Vascular Disease
Evangelos D. Michelakis, University of Alberta, Canada
Mitochondrial Modulators in Pulmonary Arterial Hypertension
Nicholas Morrell, University of Cambridge, UK
Generation of Patient-Derived Induced Pluripotent Stem Cells
to Study BMP Receptor Dysfunction
Short Talk(s) Chosen from Abstracts
Workshop 2: MicroRNAs and iPS Cells Novel Tools and Targets
in Cardiovascular Biology and Pulmonary Vascular Research
Nicholas Morrell*, University of Cambridge, UK
Short Talks Chosen from Abstracts
The Right Ventricle in Pulmonary Hypertension:
Cardiomyocyte Function and Hemodynamic Performance
Evangelos Michelakis*, University of Alberta, Canada
Kurt R. Stenmark*, University of Colorado Denver, USA
Stephen L. Archer, University of Chicago Medical Center, USA
Right Ventricular Cardiomyocyte Function: Impact of Pressure, Volume Load
and PH Therapy
WEDNESDAY, SEPTEMBER 12 (CONTINUED)
Titus Kuehne, German Heart Institute, Germany
Assessment of Right Ventricular Function by MRI and Pressure-Volume Loops
Andrew Redington, Hospital for Sick Children, Canada
Interactions between Right and Left Ventricle in Pulmonary Hypertension
Short Talk Chosen from Abstracts
THURSDAY, SEPTEMBER 13
MicroRNAs in Proliferative Vascular Disease
Margaret R. MacLean*, University of Glasgow, UK
Andrew H. Baker, University of Glasgow, UK
MicroRNAs in Vascular Remodeling and PAH
Norbert Voelkel, Virginia Commonwealth University, USA
Histone (Deacetylation in the Right Ventricle and Pulmonary Vasculature
Joseph Loscalzo, Brigham and Womens Hospital, Harvard Medical School, USA
Hypoxamirs in the Pulmonary Endothelium
Sebastien Bonnet, Universit Laval, Canada
Role for DNA Repair and miRNAs in the Epigenetics Abnormalities Seen in PAH
Short Talk(s) Chosen from Abstracts
Innovative Clinical PAH Trials
Stuart Rich, University of Chicago Medical Center, USA
Clinical Trial Design for Pulmonary Hypertension
H. Ardeschir Ghofrani, Justus Liebig University Giessen, Germany
Preliminary/Unpublished Results Randomized Controlled Trial
Mark Nicolls, Stanford University School of Medicine, USA
Targeting Immunity in the Treatment of PAH: The Rituximab SSc-PAH Trial
Short Talk Chosen from Abstracts
FRIDAY, SEPTEMBER 14
Pulmonary Hypertension in Parenchymal Lung
and Thromboembolic Diseases
Stella Kourembanas*, Childrens Hospital Boston, Harvard Medical School, USA
Mark A. Krasnow*, Stanford University School of Medicine, USA
Building the Pulmonary Artery
Bernard Thbaud, University of Alberta, Canada
Progenitor Cells in Diaphragmatic Hernia, Pulmonary Hypoplasia and PH Associated
with Neonatal Lung Injury
Jane A. Mitchell, Imperial College London, UK
The Role of PPAR in Pulmonary Hypertension and Idiopathic Pulmonary Fibrosis
Stuart W. Jamieson, University of California, San Diego Medical Center, USA
Unique Features of Chronic Thromboembolic Pulmonary Hypertension
Short Talk(s) Chosen from Abstracts
Workshop 3: Vascular Metabolomics and Proteomics:
Where Are the Novel Biomarkers for Pulmonary Vascular Diseases?
Martin R. Wilkins*, Imperial College London, UK
Short Talks Chosen from Abstracts
Pulmonary Arterial Hypertension
Current Concepts and Future Therapies
Stephen L. Archer*, University of Chicago Medical Center, USA
Georg Hansmann*, Childrens Hospital Boston, Harvard Medical School, USA
Margaret R. MacLean*, University of Glasgow, UK
Short Talk(s) Chosen from Abstracts
Novel Therapeutic Targets for PAH and RV Dysfunction
Kurt R. Stenmark, University of Colorado Denver, USA
The Microenvironment in Vascular Remodeling and Repair:
Inlammatory Fibroblasts and Beyond
Jeffrey Fineman, University of California, San Francisco, USA
Systemic-to-Pulmonary Shunts: How Vascular Gene Expression and Function Depend
on Pulmonary Blood Flow and Pressure
Martin R. Wilkins, Imperial College London, UK
Novel Biomarkers for Pulmonary Vascular Disease and RV Dysfunction
Timothy M. Moore, NHLBI, National Institutes of Health, USA (panelist)
SATURDAY, SEPTEMBER 15: DEPARTURE
*Session Chair
7
Scientic Organizers: Georg Hansmann, Stephen L. Archer and Margaret R. MacLean
Sponsored by Bayer USA Foundation
AGING AND DISEASES OF AGING
OCTOBER 2227, 2012
SHERATON MIYAKO HOTEL TOKYO, TOKYO, JAPAN
(venue information on page 21)
DEADLINES:
ABSTRACT & SCHOLARSHIP CLOSED
LATE-BREAKING ABSTRACT JUL 25, 2012
DISCOUNTED REGISTRATION AUG 22, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/12S2
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/12S2.
MONDAY, OCTOBER 22: ARRIVAL & REGISTRATION
TUESDAY, OCTOBER 23
Keynote Address
David A. Sinclair, Harvard Medical School, USA
Sirtuins, Aging and Diseases of Aging
Cell Signaling I
Leonard P. Guarente, Massachusetts Institute of Technology, USA
Aging and Disease: Connections to Sirtuins
Heidi Tissenbaum, University of Massachusetts Medical School, USA
Regulation of Lifespan by C. elegans FOXO/DAF-16
Eisuke Nishida, Kyoto University, Japan
JNK/AP-1 Signaling and Longevity in C. elegans
Laura Bordone, Genomics Institute of the Novartis Foundation, USA
SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression
in Liver and Muscle Cells
Cell Signaling II
Sean M. Oldham, Sanford-Burnham Medical Research Institute, USA
The Role of the TOR Pathway in Obesity and Aging
Shin-ichiro Imai, Washington University School of Medicine, USA
The Systemic Regulatory Network for Mammalian Aging and Longevity:
The Brain, SIRT1 and the NAD World
Yousin Suh, Albert Einstein College of Medicine, USA
Functional Genomics of Human Aging
Short Talk Chosen from Abstracts
WEDNESDAY, OCTOBER 24
Stem Cells and Aging
Session Sponsored by The Ellison Medical Foundation (Support for these
organizer-selected speakers generously provided by this foundation
*Kazuo Tsubota, Keio University School of Medicine, Japan
Thomas A. Rando, Stanford University School of Medicine, USA
Muscle Stem Cells and Aging
Heinrich Jasper, University of Rochester, USA
Aging of Intestinal Stem Cells in Drosophila
Anne Brunet, Stanford University, USA
Epigenetic Regulation of Neural Stem Cell Aging
Amy J. Wagers, Harvard University, USA
Tissue Maintenance and Stem Cells
Short Talk(s) Chosen from Abstracts
Cell Signaling III
Yo-ichi Nabeshima, Foundation for Biomedical Research
and Innovation, Japan
-Klotho as a Regulator of Calcium Homeostasis
and Aging-Like Phenotype
Noboru Mizushima, Tokyo Medical and Dental University, Japan
Nutrient Signaling and Autophagy
Toren Finkel, NHLBI, National Institutes of Health, USA
Mitochondrial Dysfunction, Oxidative Stress and Autophagy
Short Talk Chosen from Abstracts
THURSDAY, OCTOBER 25
DNA Damage Response, Telomeres and Cellular Senescence
Judith Campisi, Buck Institute for Research on Aging, USA
The DNA Damage Response, Inlammation and Aging
Manuel Serrano, Spanish National Cancer Center (CNIO), Spain
Tumor Suppressors at the Interface between Cancer and Aging
Fuyuki Ishikawa, Kyoto University, Japan
Telomere and Cellular Senescence
Cynthia T. McMurray, Lawrence Berkeley National Laboratory, USA
The Role of DNA Damage Response Signals in Neurodegenerative Diseases
Short Talk(s) Chosen from Abstracts
Age-Related Neurodegenerative Diseases
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Role of Autophagy in Neurodegenerative Diseases
Andrew G. Dillin, The Salk Institute for Biological Studies, USA
Aging as an Event of Proteostasis Collapse
Dale E. Bredesen, Buck Institute for Research on Aging, USA
Role of Cell Death Signaling in Alzheimers Disease
Short Talk Chosen from Abstracts
FRIDAY, OCTOBER 26
Aging and Metabolic Diseases
Takashi Kadowaki, University of Tokyo, Japan
The Role of Adiponectin and Adiponectin Receptors in Type 2 Diabetes
and Metabolic Diseases
Juleen R. Zierath, Karolinska Institutet, Sweden
Gene/Environment Inluence in Skeletal Muscle Insulin Sensitivity
in Type 2 Diabetes Patients
Carlos Canto Alvarez, cole Polytechnique Fdrale
de Lausanne (EPFL), Switzerland
Modulating NAD
+
Levels for Targeting Metabolic Disorders
and Age-Related Physiological Decline
Eric M. Verdin, University of California, San Francisco, USA
SIRT3 Regulates Mitochondrial Protein Acetylation
and Intermediary Metabolism
Short Talk(s) Chosen from Abstracts
Aging and Cardiovascular Diseases
Edward G. Lakatta, NIA, National Institutes of Health, USA
The Stress of Aging Viewed from the Arterial Wall
Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Cardiac Aging in Drosophila
Hiroshi Itoh, Keio University School of Medicine, Japan
Metabolic Syndrome and Vascular Aging
Short Talk Chosen from Abstracts
SATURDAY, OCTOBER 27: DEPARTURE
*Session Chair
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
8
Scientic Organizers: Takashi Kadowaki, Leonard P. Guarente, Judith Campisi and Sean M. Oldham
Sponsored by Astellas Pharma Inc., Novartis Pharma K.K. and Takeda Pharmaceutical Company Limited
IMMUNOLOGICAL MECHANISMS
OF VACCINATION
DECEMBER 1318, 2012
FAIRMONT CHTEAU LAURIER, OTTAWA, ONTARIO, CANADA
(venue information on page 21)
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/12S3.
DEADLINES:
GLOBAL HEALTH TRAVEL AWARD JUL 17, 2012
ABSTRACT & SCHOLARSHIP AUG 13, 2012
LATE-BREAKING ABSTRACT SEP 13, 2012
DISCOUNTED REGISTRATION OCT 11, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/12S3
THURSDAY, DECEMBER 13: ARRIVAL & REGISTRATION
Keynote Address
Bruce A. Beutler, University of Texas Southwestern
Medical Center, USA
Genetics and Innate Immunity
FRIDAY, DECEMBER 14
Innate Sensing of Pathogens and Vaccines
Akiko Iwasaki

, Yale University School of Medicine, USA


Talk Title to be Determined
Speaker to be Announced
Dana Philpott, University of Toronto, Canada
NOD Receptors and Adaptive Immunity
William R. Heath, University of Melbourne, Australia
Dendritic Cells and T Cell Induction
Short Talk(s) Chosen from Abstracts
Augmenting Immune Responses to Vaccines
Robert A. Seder, NIAID, National Institutes of Health, USA
Optimizing Adaptive Immunity with Immune Adjuvants
Tania H. Watts, University of Toronto, Canada
TNF Family Members in Acute and Chronic Infection:
Implications for Vaccination
Daniel D. Pinschewer, University of Geneva, Switzerland
Recombinant LCMV Vaccine Vectors
Short Talk Chosen from Abstracts
SATURDAY, DECEMBER 15
T Cell Memory to Vaccines
Ton N. Schumacher, Netherlands Cancer Institute, Netherlands
Technologies for Tracking T Cell Responses
John T. Harty, University of Iowa, USA
Alternative Strategies for Generating Memory CD8 T Cells
by Prime-Boost Immunization
Marc K. Jenkins, University of Minnesota Medical School, USA
CD4
+
T Cell Memory
David Masopust, University of Minnesota, USA
CD8 T Cell Memory Induced by Heterologous Prime-Boost Vaccination
Short Talk(s) Chosen from Abstracts
B Cell Memory to Vaccines
Antonio Lanzavecchia

, Institute for Research


in Biomedicine, Switzerland
Talk Title to be Determined
Michel C. Nussenzweig, Rockefeller University, USA
Human Antibody Responses to HIV
Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
Th Cells: Providing T Cell Help for B Cell Responses
Short Talk Chosen from Abstracts
SUNDAY, DECEMBER 16
Understanding Signatures of Vaccine Protective Eficacy
Bali Pulendran, Emory University, USA
Systems Vaccinology
Ennio De Gregorio, Novartis Vaccines and Diagnostics, Italy
Innate Immune Signatures of Vaccine Adjuvants
Raick P. Skaly, Vaccine & Gene Therapy Institute, USA
RNA Immunoproiling of Vaccines
Susan M. Kaech, Yale University School of Medicine, USA
Talk Title to be Determined
Short Talk(s) Chosen from Abstracts
Translating Immunity to Vaccines
Dan H. Barouch, Harvard Medical School, Beth Israel Deaconess
Medical Center, USA
HIV Vaccine Design
Helen McShane, University of Oxford, UK
Clinical Development of TB Vaccines
Speaker to be Announced
Short Talk Chosen from Abstracts
MONDAY, DECEMBER 17
Immunity and Vaccines Against Global Threats I
Adrian V.S. Hill, University of Oxford, UK
Malaria Vaccine Challenges
Farshad Guirakhoo

Sanoi Pasteui 0SA


New Dengue Vaccines
Rai Ahmed, Emory University School of Medicine, USA
Immune Mechanisms in Inluenza Vaccination
Dennis L. Kasper, Harvard Medical School, USA
Immune Responses to Polysaccharide Vaccine Antigens
Short Talk(s) Chosen from Abstracts
Immunity and Vaccines Against Global Threats II
Louis J. Picker, Oregon Health & Science University, USA
Cytomegalovirus as a Vector for HIV Vaccines
Jerald C. Sadoff, Crucell NV, Netherlands
Vaccine Vectors for HIV and Other Global Threats
Willem A. Hanekom, University of Cape Town, South Africa
Field Studies of TB Vaccines
Short Talk Chosen from Abstracts
TUESDAY, DECEMBER 18: DEPARTURE

Invited, not yet accepted


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
9
Scientic Organizers: Adrian V.S. Hill, Dan H. Barouch, John T. Harty and Tania H. Watts
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
TYPE 2 IMMUNITY: INITIATION, MAINTENANCE,
HOMEOSTASIS AND PATHOLOGY
JANUARY 1015, 2013
SANTA FE COMMUNITY CONVENTION CENTER, SANTA FE, NEW MEXICO, USA
(venue information on page 21)
Scientic Organizers: Richard M. Locksley and Judith E. Allen
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J1.
JOINT WITH...
THURSDAY, JANUARY 10: ARRIVAL & REGISTRATION
Keynote Address (Joint)
Bart N. Lambrecht, Ghent University, Belgium
The Dendritic Cell Network and the Response to Allergens
FRIDAY, JANUARY 11
Adaptations to Chronic Helminth Infection
Fred D. Finkelman, University of Cincinnati, USA
Overview of Adaptations to Intestinal Helminths
Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
Parasitic Helminths and the Human Immune Response
Ajay Chawla, University of California, San Francisco, USA
Metabolic Consequences of Type 2 Immunity
Speaker to be Announced
Short Talk(s) Chosen from Abstracts
Regulating the Type 2 Cytokines
Dirk E. Smith, Amgen Inc., USA
The Role of IL-33 in Regulating Innate Airway Inlammation
Steven F. Ziegler, Benaroya Research Institute and University
of Washington School of Medicine, USA
TSLP in the Regulation of Type 2 Immunity
Richard M. Maizels, University of Edinburgh, UK
Coaptation of the Host Immune Response by Parasitic Helminths
Short Talk Chosen from Abstracts
SATURDAY, JANUARY 12
Innate Helper Cells in Type 2 Immunity (Joint)
Andrew N.J. McKenzie, Medical Research Council, UK
Nuocytes, IL-33 and Lung Inlammation
Hergen Spits, University of Amsterdam, Netherlands
The Spectrum of Human Innate Lymphoid Cells
Richard M. Locksley, University of California, San Francisco, USA
Function-Marking Innate Helper Type 2 Cells
Shigeo Koyasu, Keio University School of Medicine, Japan
Type 2 Innate Immune Responses and the Natural Helper Cell
Adaptive Th2 and TFH Cells
Speakers to be Announced
Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
Th2 Th Cell Determinants
Short Talk Chosen from Abstracts
SUNDAY, JANUARY 13
Commensals, Immunity and Epithelial Homeostasis
Speaker to be Announced
Wenjun Ouyang, Genentech, Inc., USA
The IL-10/22 Family of Cytokines in Epithelial Health
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Parasites and the Commensal Flora
Sabine Eming, University of Cologne, Germany
Tissue Repair and Type 2 Immunity
Short Talk(s) Chosen from Abstracts
Myeloid Cells in Tissue Homeostasis
Judith E. Allen, University of Edinburgh, UK
AAMs
David Voehringer, University Hospital of Erlangen, Germany
Eosinophils What Have We Learned?
Hajime Karasuyama, Tokyo Medical and Dental University, Japan
Basophils Innate Cells Regulated by the Adaptive Response
Short Talk Chosen from Abstracts
MONDAY, JANUARY 14
Initiating Type 2 Immunity (Joint)
Ruslan M. Medzhitov

, Yale University School of Medicine, USA


Proteases Drive Allergic Inlammation
Jenny P. Ting, University of North Carolina at Chapel Hill, USA
Uric Acid and the Inlammasome
Marco Idzko, University Hospital Freiburg, Germany
ATP and P2X Receptors in Type 2 Immunity
Jack A. Elias, Yale School of Medicine, USA
Chitin and Chitinases
Pathologic Syndromes
Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Lymphocyte Defects in Hyper IgE Syndromes
Thomas A. Wynn, NIAID, National Institutes of Health, USA
Pathogenesis of Type 2 Immunity
Lawren C. Wu, Genentech, Inc., USA
IgE Production and Memory in Health and Disease
Short Talk Chosen from Abstracts
TUESDAY, JANUARY 15: DEPARTURE

Invited, not yet accepted


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
10
10
PATHOGENIC PROCESSES
IN ASTHMA AND COPD
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J2.
DEADLINES FOR BOTH CONFERENCES:
ABSTRACT & SCHOLARSHIP SEP 10, 2012
LATE-BREAKING ABSTRACT OCT 10, 2012
DISCOUNTED REGISTRATION NOV 8, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13J1 or /13J2
Scientic Organizers: Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston
Registering for one conference in a set of joint conferences enables
participation in sessions of the other, pending space availability.
THURSDAY, JANUARY 10: ARRIVAL & REGISTRATION
Keynote Address (Joint)
Bart N. Lambrecht, Ghent University, Belgium
The Dendritic Cell Network and the Response to Allergens
FRIDAY, JANUARY 11
New Insights into the Pathogenesis of Lung Diseases
Sally E. Wenzel, University of Pittsburgh, USA
Emerging Concepts on the Heterogeneity of Asthma
Fernando D. Martinez, University of Arizona, USA
Early-Life Origins of Chronic Obstructive Pulmonary Disease
Avrum Spira, Boston University, USA
Molecular Insights into COPD via Transcriptomic Proiling
Ian M. Adcock, Imperial College London, UK
Epigenetic Regulation of Lung Diseases
Short Talk(s) Chosen from Abstracts
Infectious Origins of Lung Disease
James E. Gern, University of Wisconsin, USA
Virus Infections and Asthma Inception and Exacerbation
Sebastian L. Johnston, Imperial College London, UK
Mechanisms of Rhinovirus-Induced Exacerbations in Asthma
and COPD
Michael J. Holtzman, Washington University, USA
Immune Pathways Translating Viral Infection into Chronic
Airway Disease
Short Talk Chosen from Abstracts
SATURDAY, JANUARY 12
Innate Helper Cells in Type 2 Immunity (Joint)
Andrew N.J. McKenzie, Medical Research Council, UK
Nuocytes, IL-33 and Lung Inlammation
Hergen Spits, University of Amsterdam, Netherlands
The Spectrum of Human Innate Lymphoid Cells
Richard M. Locksley, University of California, San Francisco, USA
Function-Marking Innate Helper Type 2 Cells
Shigeo Koyasu, Keio University School of Medicine, Japan
Type 2 Innate Immune Responses and the Natural Helper Cell
Role of Th17 Cells in the Regulation of Lung Immunity
Jay K. Kolls, University of Pittsburgh School of Medicine, USA
Th17 Cells as Critical Regulators of Host Immunity to Bacterial
and Fungal Infections at Mucosal Surfaces
Susan V. Lynch, University of California, San Francisco, USA
Airway Microbiota and Lung Disease
Marsha Wills-Karp, Johns Hopkins Bloomberg School
of Public Health, USA
Microbiota Regulation of Th17-Mediated Severe Asthma
Short Talk Chosen from Abstracts
SUNDAY, JANUARY 13
Lung Development, Repair and Remodeling
Jeffrey A. Whitsett, Cincinnati Childrens Hospital Medical Center, USA
Transcriptional Networks Linking Mucus Metaplasia and Innate Immunity
in the Respiratory Epithelium
Paul W. Noble, Duke University, USA
Matrix Regulation of Lung Injury, Inlammation and Repair
Darryl Knight, University of British Columbia, Canada
Stem Cells for Repair of the Airways
Joanne L. Wright, University of British Columbia, Canada
Cigarette-Smoke-Induced COPD
Short Talk(s) Chosen from Abstracts
Mechanisms of Chronic Obstructive Pulmonary Disease
Shyam Biswal, Johns Hopkins Bloomberg School of Public Health, USA
Oxidative Stress Regulation of Lung Inlammation in COPD
Augustine Choi, Harvard Medical School, USA
Regulation and Function of Autophagy in COPD
Farrah Kheradmand, Baylor College of Medicine, USA
Autoreactive T Cells in the Pathophysiology of Human
and Mouse Emphysema
Short Talk Chosen from Abstracts
MONDAY, JANUARY 14
Initiating Type 2 Immunity (Joint)
Ruslan M. Medzhitov

, Yale University School of Medicine, USA


Proteases Drive Allergic Inlammation
Jenny P. Ting, University of North Carolina at Chapel Hill, USA
Uric Acid and the Inlammasome
Marco Idzko, University Hospital Freiburg, Germany
ATP and P2X Receptors in Type 2 Immunity
Jack A. Elias, Yale School of Medicine, USA
Chitin and Chitinases
Therapeutic Opportunities in Asthma and COPD
Ruth Tal-Singer, GlaxoSmithKline, USA
Challenges and Opportunities in COPD Drug Development
John G. Matthews, Genentech, Inc., USA
Anti-IL-13 Therapy in Asthma
Alison L. Budelsky, Amgen Inc., USA
Blockade of IL-17RA in Asthma
Short Talk Chosen from Abstracts
TUESDAY, JANUARY 15: DEPARTURE

Invited, not yet accepted


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
11
11
MULTIPLE SCLEROSIS
JANUARY 1116, 2013
BIG SKY RESORT, BIG SKY, MONTANA, USA
(venue information on page 21)
Scientic Organizers: Trevor J. Kilpatrick, Brenda Banwell and Hartmut Wekerle
Sponsored by Biogen Idec and the National Multiple Sclerosis Society
DEADLINES:
ABSTRACT & SCHOLARSHIP SEP 12, 2012
LATE-BREAKING ABSTRACT OCT 11, 2012
DISCOUNTED REGISTRATION NOV 12, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13A1
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A1.
rleee
FRIDAY, JANUARY 11: ARRIVAL & REGISTRATION
SATURDAY, JANUARY 12
Keynote Address
Trevor J. Kilpatrick*, University of Melbourne, Australia
Lawrence Steinman, Beckman Center for Molecular Medicine,
Stanford University, USA
An Integrated and Evolutionary Perspective to Understanding
the Pathogenesis of MS
Nature and Nurture: Insights Beyond GWAS
and Epidemiological Studies
Sreeram Ramagopalan, University of Oxford, UK
Implications of Epigenetic Changes in MS
Justin Rubio, GlaxoSmithKline, UK
Keys to Realizing the Promise of Pharmacogenomics
Speaker to be Announced
Short Talk(s) Chosen from Abstracts
Cellular and Molecular Proiling:
The Road to an Integrated Approach
Hartmut Wekerle*, Max Planck Institut, Germany
Lessons from Pathology
William H. Robinson, Stanford School of Medicine, USA
From Tissue to Proteomics and Lipidomics
Ronald N. Germain, NIAID, National Institutes of Health, USA
A Systems Biology Perspective to Autoimmunity
Short Talk Chosen from Abstracts
SUNDAY, JANUARY 13
Paraclinical Measures of Structural and Functional Change
Elliot Frohman, University of Texas Southwestern Medical Center, USA
Eye-ing a Window of Neuroprotection in the Visual System
for Multiple Sclerosis
John Gore, Vanderbilt University, USA
Recent Developments in MRI
Speaker to be Announced
Martin Kerschensteiner, Ludwig-Maximilians-University
Munich, Germany
Harnessing the Potential of Cellular and Molecular in vivo Imaging
Short Talk(s) Chosen from Abstracts
Immunopathogenesis
Jingwu Zhang Zang*, GlaxoSmithKline, China
Marc Veldhoen, Babraham Institute, UK
The Molecular Control of Immune Homeostasis
Stephen M. Anderton, University of Edinburgh, UK
Immune-Mediated Auto-Aggression and Regulation
Takashi Yamamura, National Institute of Neuroscience, NCNP, Japan
Interrogating Innate Immunity and Key Environmental Interactions
Short Talk Chosen from Abstracts
MONDAY, JANUARY 14
Clinical Controversies
Helen Tremlett, University of British Columbia, Canada
Emerging Concepts of Disease Heterogeneity in MS
Timothy Coetzee, National Multiple Sclerosis Society, USA
Lessons from CCSVI
Jun-ichi Kira, Kyushu University, Japan
Dissecting the Interface between NMO and MS
Brenda Banwell*, University of Toronto, Canada
Negotiating between ADEM, CIS and MS: An Age-Speciic Roadmap?
Short Talk(s) Chosen from Abstracts
Clinical Developments
Richard K. Burt, Northwestern University, USA
Hematopoietic Stem Cell Transplantation for Multiple Sclerosis
Jingwu Zhang Zang, GlaxoSmithKline, China
Optimizing Translational Research Pipelines in MS
Douglas Goodin*

, University of California, San Francisco, USA


The Hitchhikers Guide to Therapeutic Choice
Short Talk Chosen from Abstracts
TUESDAY, JANUARY 15
Neurobiology
Trevor J. Kilpatrick*, University of Melbourne, Australia
Peter K. Stys, University of Calgary, Canada
Axon-Glial Interactions
Ben Emery, University of Melbourne, Australia
Molecular Determinants of Myelination
Catherine Lubetzki, INSERM and UPMC, France
Translational Approaches to Remyelination
Frauke Zipp, Johannes-Gutenberg-Universitt Mainz, Germany
Crosstalk of the Immune System and the Nervous System
Short Talk(s) Chosen from Abstracts
Repair
Catherine Lubetzki*, INSERM and UPMC, France
Gianvito Martino San Raffaele Scientiic Institute Italy
The Role of Neural Stem Cells in Brain Regeneration
Trevor J. Kilpatrick, University of Melbourne, Australia
Targeting the Oligodendrocyte Lineage
Speaker to be Announced
Short Talk Chosen from Abstracts
WEDNESDAY, JANUARY 16: DEPARTURE
*Session Chair

Invited, not yet accepted


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
12
NEW FRONTIERS IN CARDIOVASCULAR
GENETICS BEYOND GWAS
JANUARY 1318, 2013
GRANLIBAKKEN RESORT, TAHOE CITY, CALIFORNIA, USA
(venue information on page 27)
DEADLINES:
ABSTRACT & SCHOLARSHIP SEP 12, 2012
LATE-BREAKING ABSTRACT OCT 11, 2012
DISCOUNTED REGISTRATION NOV 12, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13A2
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A2.
Scientic Organizers: Jennifer Hall and Stephen S. Rich
SUNDAY, JANUARY 13: ARRIVAL & REGISTRATION
MONDAY, JANUARY 14
Keynote Address
Eric D. Green, NHGRI, National Institutes of Health, USA
Entering the Era of Genomic Medicine:
Research Opportunities and Challenges
Breakthroughs in Sequencing and New Approaches
in Applications
Jennifer Hall*, University of Minnesota, USA
Stephen S. Rich*, University of Virginia, USA
Richard Wilson

, Washington University School of Medicine, USA


New Approaches and Challenges in Sequencing
Deborah A. Nickerson, University of Washington, USA
The Next Steps in Sequencing
Speaker to be Announced
Short Talk(s) Chosen from Abstracts
Integrating Brain and Heart
John Hardy*, University College London, UK
Genetic Basis of Alzheimers Disease and Ischemic Stroke
Bruce D. Gelb, Mount Sinai Medical Center, USA
Complex Genetic Networks in Cardiovascular Disease
Rich Bonneau, New York University, USA
Learning Dynamic Genome-Scale Models of Hematopoietic Stem Cell
Differentiation and Function
Short Talk Chosen from Abstracts
TUESDAY, JANUARY 15
Genetics of Coronary Artery Disease
Daniel J. Rader, University of Pennsylvania, USA
Novel Biological Pathways and Therapeutic Targets for Atherosclerosis
Tom Quertermous, Stanford University School of Medicine/
VIA Pharmaceuticals Inc., USA
Mechanisms of Coronary Heart Disease Associated Genetic Risk Loci
Kelly A. Frazer, University of California, San Diego, USA
Identifying and Characterizing Risk Loci for Coronary Artery Disease
Geoffrey S. Ginsburg*, Duke University, USA
How Do Genetic/Genomic Tests Compete?
Short Talk(s) Chosen from Abstracts
Structural Variation
Stephen S. Rich*, University of Virginia, USA
Major Discoveries of Structural Variants on Risk of Human Disease
Marcelo Nobrega, University of Chicago, USA
Regulatory Networks in Heart Development and Heart Disease
Evan E. Eichler, University of Washington, USA
Structural Variation in the Human Genome
Short Talk Chosen from Abstracts
WEDNESDAY, JANUARY 16
State of the Art in Heart Failure (Bench to Bedside)
Jennifer Hall*, University of Minnesota, USA
SNPs in miRNA Binding Sites in a Cohort of Individuals with Heart Failure
Stuart A. Cook, Imperial College London, UK
New Approaches to Understanding Cardiomyopathy
Helen H. Hobbs, University of Texas Southwestern Medical Center, USA
Genomic Approaches to Lipids, Coronary Atherosclerosis
and Metabolic Syndrome
Speaker to be Announced
Short Talk(s) Chosen from Abstracts
The Genetics of Arrhythmias
Emelia J. Benjamin*, Boston University, USA
The Genetics of Atrial Fibrillation
Calum A. MacRae, Brigham & Womens Hospital, USA
High-Throughput in vivo Exploration of Disease Networks in ebraish
Silvia G. Priori, Foundation Salvatore Maugeri, Italy
Personalized Medicine Treatment and Genotyping for Long QT Syndrome:
The Past, Present and Future
Short Talk Chosen from Abstracts
THURSDAY, JANUARY 17
Breakthroughs in Genomics and Personalized Medicine
David R. Bentley, Illumina Cambridge Ltd, UK
Genomes in Medicine
Howard J. Jacob*, Medical College of Wisconsin, USA
Whole Genome Sequencing: Just Another Clinical Lab Diagnostic?
Nola Masterson, Science Futures Inc., USA
What Is Next?
Pierre Cassigneul, XDx Expression Diagnostics, USA
Where Is the Field of Personalized Medicine in Heart Transplant?
Short Talk(s) Chosen from Abstracts
Dificulties in Going from Genotype to Phenotype
Eric A. Boerwinkle*, University of Texas, USA
Genotype to Phenotype with Hypertension: The Challenges
Aravinda Chakravarti, Johns Hopkins University School
of Medicine, USA
From Genome to Function
Nicole Soranzo, Wellcome Trust Sanger Institute, UK
From Genome to Function
Richard P. Lifton

, HHMI/Yale University School of Medicine, USA


Genomics of Personalized Medicine: The Challenges that Lie Ahead
Short Talk Chosen from Abstracts
FRIDAY, JANUARY 18: DEPARTURE
*Session Chair

Invited, not yet accepted


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
13
FRONTIERS OF NMR IN BIOLOGY
JANUARY 1318, 2013
SNOWBIRD RESORT, SNOWBIRD, UTAH, USA
(venue information on page 27)
Scientic Organizers: Gerhard Wagner, Angela M. Gronenborn and Marc Baldus
DEADLINES:
ABSTRACT & SCHOLARSHIP SEP 13, 2012
LATE-BREAKING ABSTRACT OCT 15, 2012
DISCOUNTED REGISTRATION NOV 13, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13A3
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A3.
s
SUNDAY, JANUARY 13: ARRIVAL & REGISTRATION
MONDAY, JANUARY 14
Keynote Address
Michael F. Summers, HHMI/University of Maryland
Baltimore County, USA
NMR Methods for Large RNAs and the Mechanism
of HIV-1 Genome Packaging
New Methods in Solid State NMR
Beat H. Meier, ETH Zrich, Switzerland
Amyloid Structures by Solid State NMR
Tatyana Polenova, University of Delaware, USA
Magic Angle Spinning Studies of HIV-1 Protein Assemblies
Bernd Reif, Technische Universitt Mnchen, Germany
Deuteration in and 1H Detection in Solid State NMR
Chad M. Rienstra, University of Illinois at Urbana-Champaign, USA
High-Resolution Protein Structures by Magic-Angle Spinning NMR
Short Talk Chosen from Abstracts
NMR in Cells and Cell Extracts
Philipp Selenko, FMP Berlin, Germany
Real-Time Characterization of Posttranslational Protein Modiications
in Cellular Environments
Masahiro Shirakawa, Kyoto University, Japan
In-Cell NMR Spectroscopy of Proteins inside Living Cells
Teresa Fan, University of Louisville, USA
Metabolite Flux Measurements in Living Cells
Short Talk Chosen from Abstracts
TUESDAY, JANUARY 15
Elucidating Protein Structure and Function
Kevin H. Gardner, University of Texas Southwestern
Medical Center, USA
Mechanisms of Hypoxic Gene Activation
Mitsuhiko Ikura, Ontario Cancer Institute, Canada
IP3 Receptor Binding and Channel Gating
Angela M. Gronenborn, University of Pittsburgh, USA
HIV Cellular Protein Interactions
Katherine A. Henzler-Wildman, Washington University, USA
Asymmetry and Exchange in the Mechanism of Multidrug Eflux by EmrE
Short Talk(s) Chosen from Abstracts
Workshop: Protein and RNA Production and Labeling
Nucleotides and Nucleotide/Protein Complexes
Juli Feigon, University of California, Los Angeles, USA
The Architecture of Telomerase
Walter J. Chazin, Vanderbilt University, USA
Structure and Dynamics of Integrated DNA Replication,
Damage Response and Repair Machinery
Michael J. Sattler, Technical University Munich and German
Research Center for Environmental Health, Germany
Protein-Nucleic Acid Interactions in Splicing
Short Talk Chosen from Abstracts
WEDNESDAY, JANUARY 16
Membrane Proteins
James Jeiwen Chou, Harvard Medical School, USA
Structure and Mechanism of Mitochondrial Carriers
Linda Columbus, University of Virginia, USA
Structure, Folding and Functional Studies of Opacity-Associated (Opa
Proteins from Neisseria gonorrhoeae
Marc Baldus, Utrecht University, Netherlands
Characterization of Membrane Proteins in the Solid State
Senyon Choe, The Salk Institute, USA
Facile NMR Structure Determination of Human Membrane Proteins
Short Talk(s) Chosen from Abstracts
Drug Targets, NMR in Industry
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
NMR-Based Drug Discovery in Academia
Daniel F. Wyss, Merck & Co., Inc., USA
FBDD on a Tough Target Starts to Yield
Discovery of Orally Active, Brain-Penetrant BACE1 Inhibitors
Teresa Carlomagno, EMBL Heidelberg, Germany
NMR-Based Drug Discovery Methods in Academia
Short Talk Chosen from Abstracts
THURSDAY, JANUARY 17
Solution NMR Methods
Ad Bax, NIDDK, National Institutes of Health, USA
Structures from Chemical Shifts and Databases
Gerhard Wagner, Harvard Medical School, USA
New NMR Experiments for Challenging Proteins
Gottfried Otting, Australian National University, Australia
Paramagnetic Probes for NMR Studies
Bernhard Brutscher, Institut de Biologie Structurale, France
Fast Methods in Biological NMR
Short Talk(s) Chosen from Abstracts
Folding and Disease
David Baker

, University of Washington, USA


Folding Proteins from Sparse NMR Data
Robert Tycko, National Institutes of Health, USA
Amyloid Fibril Structures, in vitro and in vivo
Christopher M. Dobson

, University of Cambridge, UK
Unfolded States, Misfolding and Disease
FRIDAY, JANUARY 18: DEPARTURE

Invited, not yet accepted


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
14
HEMATOPOIESIS
JANUARY 1419, 2013
SHERATON RESORT STEAMBOAT, STEAMBOAT SPRINGS,
COLORADO, USA (venue information on page 27)
DEADLINES:
ABSTRACT & SCHOLARSHIP SEP 13, 2012
LATE-BREAKING ABSTRACT OCT 16, 2012
DISCOUNTED REGISTRATION NOV 13, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13A4
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A4.
Scientic Organizers: Leonard I. Zon, Stuart H. Orkin and Nancy A. Speck
Sponsored by Celgene Corporation
MONDAY, JANUARY 14: ARRIVAL & REGISTRATION
TUESDAY, JANUARY 15
Developmental Hematopoiesis Including ES and iPS to Blood
Catherine Porcher, University of Oxford, UK
The SCL Complex and Hematopoiesis
Nancy A. Speck, University of Pennsylvania, USA
Hematopoietic Commitment Mediated by Runx1
Elaine A. Dzierzak, Erasmus University, Netherlands
The Developmental Origins of Adult HSCs
Gordon M. Keller, University Health Network, MaRS Centre, Canada
Multiple Waves of Hemogenic Endothelium from ES Cells
Short Talk(s) Chosen from Abstracts
Workshop 1: Stem Cell Self-Renewal
Short Talks Chosen from Abstracts
Novel Hematopoietic Regulators
Leonard I. Zon, HHMI/Childrens Hospital Boston, USA
Pathways Regulating Blood Stem Cell Self-Renewal and Engraftment
David Traver, University of California, San Diego, USA
Novel Signals Controlling Stem Cell Development in ebraish
Sean J. Morrison, HHMI/University of Texas Southwestern
Medical Center, USA
Metabolism and Stem Cells
Short Talk Chosen from Abstracts
Keynote Address
George Q. Daley, Childrens Hospital Boston, USA
Milestones and Barriers in HSC Production from ES or iPS Cells
WEDNESDAY, JANUARY 16
Adult Stem Cell Self-Renewal and Function
Emmanuelle Passegu, University of California, San Francisco, USA
Self-Renewal and DNA Repair
Amy J. Wagers, Harvard University, USA
Local and Systemic Regulation of Blood Stem Cell Function
throughout Life
Margaret A. Goodell, Baylor College of Medicine, USA
HSCs during Stress and Host Defense
Daniel G. Tenen, Harvard Stem Cell Institute, Boston, USA
and Cancer Science Institute, Singapore
Regulation of Myeloid Transcription Factors and Methylation
by Long Noncoding Intragenic RNAs
Short Talk(s) Chosen from Abstracts
Microenvironment
David T. Scadden, Massachusetts General Hospital
and Harvard University, USA
Function of the Niche in Self-Renewal of HSCs
Toshio Suda, Keio University, Japan
A Metabolic Guide to Stem Cell Homeostasis
Michael P. Cooke, Genomics Institute of the Novartis
Research Foundation, USA
Regulation of HSC Self-Renewal by the Aryl Hydrocarbon Receptor
Short Talk Chosen from Abstracts
THURSDAY, JANUARY 17
Erythroid and Megakaryocyte Development
Stuart H. Orkin, Dana-Farber Cancer Institute, USA
Regulation of Globin Gene Switching
Mitchell J. Weiss, Childrens Hospital of Philadelphia, USA
Erythroid and Megakaryocytic Gene Expression and miRNAs
Harvey Lodish, Whitehead Institute for Biomedical Research, USA
The Terminal Stages of Red Cell Development
Hanna K. A. Mikkola, University of California, Los Angeles, USA
Speciication and Self-Renewal of Hematopoietic Stem Cells
Short Talk(s) Chosen from Abstracts
Workshop 2: Differentiation of Hematopoietic Cells
Short Talks Chosen from Abstracts
Hematopoietic Cell Differentiation and Function
Bertie Gottgens, Cambridge Institute for Medical Research, UK
Combinatorial Control of Lineage Commitment
Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Transcriptional Control of Early Lymphopoiesis
Irving L. Weissman, Stanford University, USA
Myeloid Cells and Dont Eat Me Signal
Short Talk Chosen from Abstracts
FRIDAY, JANUARY 18
Leukemogenesis
Ross L. Levine, Memorial Sloan-Kettering Cancer Center, USA
Role of Mutations in Epigenetic Modiiers in Myeloid Malignancies
Scott A. Armstrong, Childrens Hospital Boston, USA
Molecular Characterization of Leukemia Stem Cell Self-Renewal
John E. Dick, Toronto General Research Institute, University Health
Network, Canada
Toward Uniication of the Genetic and Cancer Stem Cell Models
of Leukemia
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Modiication of DNA Cytosine Methylation by TET Proteins
Short Talk(s) Chosen from Abstracts
Lymphoid
Avinash S. Bhandoola, University of Pennsylvania, USA
Establishing T Cell Identity
Sten Erik W. Jacobsen, University of Oxford, UK
Origin of Lymphoid Lineages
Ellen Rothenberg, California Institute of Technology, USA
Sequential Operation of Gene Regulatory Networks in the Stem Cell
to T Cell Commitment Process
Short Talk Chosen from Abstracts
SATURDAY, JANUARY 19: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
15
EMERGING TOPICS IN IMMUNE SYSTEM
PLASTICITY: CELLULAR NETWORKS,
METABOLIC CONTROL AND REGENERATION
JANUARY 1520, 2013
SANTA FE COMMUNITY CONVENTION CENTER, SANTA FE,
NEW MEXICO, USA (venue information on page 21)
Scientic Organizers: Steven L. Reiner, Erika L. Pearce and Yasmine Belkaid
DEADLINES:
ABSTRACT & SCHOLARSHIP SEP 18, 2012
LATE-BREAKING ABSTRACT OCT 17, 2012
DISCOUNTED REGISTRATION NOV 14, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster session or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13A5.
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A5.
TUESDAY, JANUARY 15: ARRIVAL & REGISTRATION
WEDNESDAY, JANUARY 16
Keynote Address
Ruslan M. Medzhitov, Yale University School of Medicine, USA
Signals, Noise and Cell Decisions
Novel Innate and Adaptive Cell Types
Luke A. J. ONeill, Trinity College Dublin, Ireland
Signaling Innate Immunity and Inlammation
Brigitta Stockinger, MRC National Institute for Medical Research, UK
Th17 Variants
David Artis, University of Pennsylvania, School of Medicine, USA
Innate Lymphocytes in Barrier Immunity
Metabolic Regulation of the Immune Response
Erika L. Pearce, Washington University School of Medicine, USA
Metabolism and the Fate of CD8+ T Cells
Douglas R. Green, St. Jude Childrens Research Hospital, USA
Central Metabolic Mechanisms in Cancer and the Immune System
Short Talks Chosen from Abstracts
THURSDAY, JANUARY 17
Targeted Control of Immune Responses
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Immune Regulation in the Intestine
Alexander Y. Rudensky, Memorial Sloan-Kettering Cancer Center, USA
Molecular Control of Regulatory T Cell Plasticity
Akiko Iwasaki, Yale University School of Medicine, USA
Cellular Control of Barrier Immunity
John J. OShea, NIAMS, National Institutes of Health, USA
Therapeutic Application of Jak/Stat Inhibition
Orchestrating Humoral Immunity
Jason G. Cyster, University of California, San Francisco, USA
Germinal Center Dynamics
Kenneth M. Murphy, Washington University School of Medicine, USA
Coordinating Transcriptional Control of T Cells and B Cells
Antonio Lanzavecchia, Institute for Research in Biomedicine,
Switzerland
Human B Cell Memory
FRIDAY, JANUARY 18
Host-Microbe Interface in the Immune Response
Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA
Inlammation and Infectious Diseases
Short Talks Chosen from Abstracts
Aviv Regev, Massachusetts Institute of Technology, USA
Biological Networks in Development and Immunity
Julie Magarian Blander, Mount Sinai School of Medicine, USA
Vita-PAMPs: Signatures of Microbial Viability
Plasticity of the Microenvironment
Marc Veldhoen, Babraham Institute, UK
Aryl Hydrocarbon Receptors as Interpreters and Defenders
of Barrier Integrity
Shannon J. Turley, Dana-Farber Cancer Institute, Harvard Medical
School, USA
Immunological Hallmarks of Inlamed Stroma
Speaker to be Announced
Cutting-Edge Talk on Tumor Microenvironment
SATURDAY, JANUARY 19
Cell Fate Speciication of Lymphocytes
Short Talks Chosen from Abstracts
Amy J. Wagers, Harvard University, USA
Maintenance and Renewal of Tissue-Speciic Stem Cells
Steven L. Reiner, Columbia University, USA
Generating Cellular Diversity through Asymmetric Division
Alexander (Sasha) Tarakhovsky, Rockefeller University, USA
Regulation of Cell Identity by Histone Methylation
Network Analysis across Evolution
Eric H. Davidson, California Institute of Technology, USA
Evolution of Gene Networks Controlling Development
Keynote Address
Elaine Fuchs, HHMI/Rockefeller University, USA
Crosstalk between Stem Cells and their Microenvironment
SUNDAY, JANUARY 20: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
16
PLANT ABIOTIC STRESS AND SUSTAINABLE
AGRICULTURE: TRANSLATING BASIC
UNDERSTANDING TO FOOD PRODUCTION
JANUARY 1722, 2013
SAGEBRUSH INN & CONFERENCE CENTER, TAOS, NEW MEXICO, USA
(venue information on page 27)
DEADLINES:
ABSTRACT & SCHOLARSHIP SEP 19, 2012
LATE-BREAKING ABSTRACT OCT 18, 2012
DISCOUNTED REGISTRATION NOV 14, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13A6
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A6.
Scientic Organizers: Julia Bailey-Serres and Paul Michael Hasegawa
Sponsored by Monsanto Company
THURSDAY, JANUARY 17: ARRIVAL & REGISTRATION
FRIDAY, JANUARY 18
Keynote Address
Marc Van Montagu, Ghent University, Belgium
Embracing Global Challenges in Agriculture
Harnessing Genetic Diversity to Improve
Crop Stress Tolerance
Mark Tester, University of Adelaide, Australia
Harnessing Diversity for Salt and Drought Tolerance in Cereals
Julia Bailey-Serres, University of California, Riverside, USA
Mechanisms of Flooding Tolerance in Rice
Sigrid Heuer, International Rice Research Institute, Philippines
Molecular Breeding and Genes for Rice with Low-Phosphorus Tolerance
Short Talks Chosen from Abstracts
Extremes in Water Availability: From Genes to Field
Rens Voesenek, Utrecht University, Netherlands
Submergence Coping Mechanisms in Wild Species
Kazuo Shinozaki, RIKEN Plant Science Center, Japan
Omics of Abiotic Stresses: Networks and Responses
Michael L. Nuccio, Syngenta Biotechnology, Inc., USA
Improvement of Drought Tolerance in Crops
Short Talk Chosen from Abstracts
SATURDAY, JANUARY 19
Understanding and Improving Water Use Eficiency
Michael V. Mickelbart, Purdue University, USA
Mechanisms Underlying Water Use Eficiency
Alistair Hetherington, University of Bristol, UK
Environmental Regulation of Stomatal Dynamics
Dominique Bergmann, Stanford University, USA
Regulation of Stomatal Development and Performance
in Reference Monocot and Dicot Species
Short Talks Chosen from Abstracts
Stress Sensing, Signaling and Response Networks
Sean Cutler, University of California, Riverside, USA
Structure and Function of ABA Receptors
Jian-Kang Zhu, Purdue University, USA
Osmotic Stress Sensing and Signaling in Arabidopsis
Ron Mittler, University of North Texas, USA
Dissecting the Rapid Systemic Signaling Pathway of Plants
Short Talk Chosen from Abstracts
SUNDAY, JANUARY 20
Roots and their Environment
Luis Herrera-Estrella, Cinvestav, Mexico
Root Architecture Remodeling for Nutrient Acquisition
Leon V. Kochian, Cornell University, USA
How Do Plants Tolerate Toxic Metals in the Soil?
Aluminum Tolerance as an Example
Mary Lou Guerinot, Dartmouth College, USA
From the Soil to the Seed: Metal Homeostasis in Plants
Maria J. Harrison, Boyce Thompson Institute for Plant Research, USA
Interrelationship between Plant Phosphate Acquisition and Mycorrhizae
Stress Systems Biology to Genetic Variation
Jerzy Paszkowski, University of Geneva, Switzerland
Epigenetics Regulation of Abiotic Stress Responses
Philip N. Benfey, Duke University, USA
Systems Integrating Root Development and Environmental Cues
Dirk Inz, Ghent University-VIB, Belgium
Impact of Stress on Growth and Development
Short Talk Chosen from Abstracts
MONDAY, JANUARY 21
Challenges and Solutions in the Field
Donald E. Nelson, Monsanto Company, USA
Advances in Engineering Abiotic Tolerance in Key Crops
Mitch R. Tuinstra, Purdue University, USA
Prospects for Adapting Maize to Drought and High-Temperature Stresses
Richard James, CSIRO, Australia
Development and Evaluation of Salt-Tolerant Wheat
Short Talks Chosen from Abstracts
Global Climate Change: CO
2
and Temperature
Philip Wigge, John Innes Centre, UK
Temperature Sensing Pathways in Plants
Lisa Ainsworth, USDA ARS, University of Illinois
at Urbana-Champaign, USA
Maximizing Soybean Production in a High CO
2
World
Susan von Caemmerer, Australian National University, Australia
Impacts of Elevated CO
2
on Photosynthesis and Other Processes
Short Talk Chosen from Abstracts
TUESDAY, JANUARY 22: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
17
NONCODING RNAS
IN DEVELOPMENT AND CANCER
JANUARY 2025, 2013
FAIRMONT HOTEL VANCOUVER, VANCOUVER,
BRITISH COLUMBIA, CANADA (venue information on page 21)
DEADLINES:
ABSTRACT & SCHOLARSHIP SEP 20, 2012
LATE-BREAKING ABSTRACT OCT 22, 2012
DISCOUNTED REGISTRATION NOV 15, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster session or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13A7
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A7.
Scientic Organizers: Joshua T. Mendell, Phillip A. Sharp, Judy Lieberman and Howard Y. Chang
Sponsored by Isis Pharmaceuticals, Inc.
SUNDAY, JANUARY 20: ARRIVAL & REGISTRATION
Keynote Session
Jeannie T. Lee, Massachusetts General Hospital, USA
X-Chromosome Inactivation as a Model for Regulation
by Long Noncoding RNA
V. Narry Kim, Seoul National University, South Korea
miRNA Processing and Mechanism
MONDAY, JANUARY 21
MicroRNAs in Development
Victor R. Ambros, University of Massachusetts, USA
miRNAs in Developmental Timing
Antonio J. Giraldez, Yale University, School of Medicine, USA
miRNAs in ebraish Development
Eric N. Olson, University of Texas Southwestern Medical Center, USA
miRNAs in Cardiac Development and Disease
Andrea Ventura, Memorial Sloan-Kettering Cancer Center, USA
miRNAs in Mammalian Development and Disease
Short Talk(s) Chosen from Abstracts
Mechanisms of Small RNA Functions
Phillip A. Sharp, Massachusetts Institute of Technology, USA
Regulation and Function of Small RNA Pathways
Judy Lieberman, Immune Disease Institute, USA
A Systems Approach to Understanding Gene Networks Regulated
by Oncomirs
Irene Bozzoni, University La Sapienza, Rome, Italy
Regulation of miRNA Function by Competing Endogenous RNAs
Short Talk Chosen from Abstracts
TUESDAY, JANUARY 22
Long Noncoding RNAs in Development
Peter Fraser, Babraham Institute, UK
LncRNA and Higher-Order Chromatin and Chromosome Structure
Caroline Dean, John Innes Centre, UK
LncRNAs and Flowering Control in Plants
Genevive Almouzni, Centre National
ue la Recheiche Scientiique Fiance
LncRNA and Centrometric Heterochromatin
Kathrin Plath, University of California, Los Angeles, USA
X Inactivation and Reactivation in Induced Pluripotency
Short Talk(s) Chosen from Abstracts
Small RNAs in Pluripotent Cells
Gregory J. Hannon, Cold Spring Harbor Laboratory, USA
Talk Title to be Determined
Robert H. Blelloch, University of California, San Francisco, USA
Small RNA Regulation of Pluripotency
George Q. Daley, Childrens Hospital Boston, USA
Lin28 in Development and Disease
Short Talk Chosen from Abstracts
WEDNESDAY, JANUARY 23
MicroRNAs in Cancer
Tyler Jacks, Massachusetts Institute of Technology, USA
miRNA Expression and Function in Cancer
Joshua T. Mendell, University of Texas Southwestern Medical Center, USA
miRNAs in Cancer Signaling Pathways
Frank J. Slack, Yale University, USA
miRNAs as Oncogenes and Tumor Suppressors
Chang-Zheng Chen, Stanford University, USA
miRNAs in Lymphocytes and Leukemias
Short Talk(s) Chosen from Abstracts
Workshop: Therapeutic Applications of Noncoding RNAs
Sakari Kauppinen, Santaris Pharma A/S, Denmark
LNA-Based Anti-miRNA Therapeutics
Eric G. Marcusson, Regulus Therapeutics, USA
Discovery and Development of Anti-miRNA Therapeutics
Andreas G. Bader, Mirna Therapeutics Inc., USA
miRNA Replacement Therapy
Eva van Rooij, miRagen Therapeutics, USA
Targeting miRNAs in Cardiovascular Disease
Processing of Noncoding RNAs
Manel Esteller, IDIBELL, Spain
Mechanisms of Altered miRNA Processing in Cancer
Richard Iain Gregory, Harvard Medical School, Childrens Hospital, USA
Regulation of miRNA Processing by Lin28
Alexei A. Aravin, California Institute of Technology, USA
Regulation of piRNA Processing
Short Talk Chosen from Abstracts
THURSDAY, JANUARY 24
Long Noncoding RNAs in Cancer
Howard Y. Chang, Stanford University, USA
Long Noncoding RNAs and Cancer Progression
Arul M. Chinnaiyan, University of Michigan, USA
LncRNAs Discovery and Use as Noninvasive Biomarkers in Prostate Cancer
John S. Mattick, Garvan Institute of Medical Research, Australia
The Role of Regulatory RNA in Human Development
Michael G. Rosenfeld, HHMI/University of California, San Diego, USA
Moving Stories about lncRNA
Short Talk(s) Chosen from Abstracts
ncRNAs in Transcriptional Control and Chromatin
Antonin Morillon, Institut Curie, France
Yeast Cryptic ncRNAs and Chromatin Regulation
Gary Felsenfeld, NIDDK, National Institutes of Health, USA
ncRNA and Organization of Chromatin Domains
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
The RNAi Pathway in Chromatin Regulation
Short Talk Chosen from Abstracts
FRIDAY, JANUARY 25: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
18
MALARIA
JANUARY 2025, 2013
JW MARRIOTT NEW ORLEANS, NEW ORLEANS, LOUISIANA, USA
(venue information on page 27)
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A8.
Scientic Organizers: Fidel P. Zavala, Andrew P. Waters, Kevin Marsh
and Carolina V. Barillas-Mury
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Additional support from Medicines for Malaria Venture Ian Bathurst Global Health Travel Awards
SUNDAY, JANUARY 20: ARRIVAL & REGISTRATION
MONDAY, JANUARY 21
Keynote Address
Alan Cowman, Walter and Eliza Hall Institute
of Medical Research, Australia
Mechanisms of Merozoite Invasion of Erythrocytes
Understanding Protective Immunity Against Plasmodium
Kevin Marsh, Kenya Medical Research Institute/Wellcome Trust
Research Program, Kenya
Immune Responses to Malaria in Endemic Areas
Susan K. Pierce, NIAID, National Institutes of Health, USA
Antibody Responses and Development of B-Cell Memory, or Lack of It
Jean Langhorne, National Institute for Medical Research, UK
CD4 T Cells as Regulators and Effectors in the Immune Response
to Malaria
William R. Heath, University of Melbourne, Australia
Innate Immune Responses: Role of Dendritic Cells in Protection
and Pathogenesis
Fidel P. Zavala, Johns Hopkins Bloomberg School of Public Health, USA
Effector Liver-Resident CD8+ T Cells
New Approaches to Vaccination
Robert Sauerwein, Radboud University, Netherlands
Experimental Vaccination of Humans with Sporozites
Simon J. Draper, University of Oxford, UK
Combinatorial Vaccines Against Blood Stages
Sarah Reece, University of Edinburgh, UK
The Private Life of Parasites: Implications for Blocking Transmission
Short Talk Chosen from Abstracts
TUESDAY, JANUARY 22
Cellular and Molecular Biology of Plasmodium
Robert Mnard, Institut Pasteur, France
Molecular Basis of Plasmodium zoite Invasion into Host Cells
Volker Heussler, Institute of Cell Biology, Switzerland
Biology of Plasmodium Liver Stage
Maria M. Mota, Instituto de Medicina Molecular, Portugal
Development of Malaria Liver Stages
Manoj Duraisingh, Harvard School of Public Health, USA
Parasite Invasion in Genetically Modiied Erythrocytes
Short Talk(s) Chosen from Abstracts
Integrating Genomic Science and Population Biology
Speaker to be Announced
Gilean McVean, University of Oxford, UK
Using de novo Assembly to Track Hypervariable Genes
in Malaria Parasites
Michael T. Ferdig, Notre Dame University, USA
How Does the Parasite Fight Back?
Short Talk Chosen from Abstracts
WEDNESDAY, JANUARY 23
Vector Biology and Malaria Transmission
Carolina V. Barillas-Mury, NIAID, National Institutes of Health, USA
Biology of Vector-Parasite Interactions
George Dimopoulos, Johns Hopkins University, USA
Anopheles Functional Genomics
Flaminia Catteruccia, Harvard School of Public Health, USA
Reproductive Biology of Anopheles Mosquitoes and Malaria Transmission
Luciano Andrade Moreira, Instituto de Pesquisas Ren
Rachou-Fiocruz, Brazil
Use of Wolbachia for Control of Vector-Borne Diseases
Short Talk(s) Chosen from Abstracts
Biology of Plasmodium Transmission Stages
Andrew P. Waters, University of Glasgow, UK
RNA Biology and Zygote Development
Oliver Billker, Wellcome Trust Sanger Institute, UK
Signaling and Zygote Development
Jake Baum, Walter and Eliza Hall Institute of Medical Research, Australia
Cell Motility and Parasite Transmission
Short Talk Chosen from Abstracts
THURSDAY, JANUARY 24
Epidemiology and Pathogenesis of Severe Malaria
Emelda Okiro, Kenya Medical Research Institute/Wellcome Trust
Research Programme, Kenya
Epidemiology and Populational Aspects of Severe Disease
Terrie E. Taylor, Michigan State University, USA
Current Understanding of Pathogenesis of Severe Malaria in Humans
Christian Engwerda Queenslanu Institute of Neuical Reseaich Austialia
Mechanisms of Pathogenesis in Experimental Models
Dominic Kwiatkowski, Oxford University and Wellcome Trust
Sanger Institute, UK
Genetics of Disease Susceptibility
Short Talk(s) Chosen from Abstracts
Mechanisms of Drug Resistance
David A. Fidock, Columbia University, USA
Cellular and Molecular Basis of Drug Resistance
Dyann F. Wirth, Harvard University, USA
Genetics Analysis of Drug Resistance
Xin-Zhuan Su, NIAID, National Institutes of Health, USA
Whole Genome Approaches to Identify Drugs that Work
and Why Others Dont
Short Talk Chosen from Abstracts
FRIDAY, JANUARY 25: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
DEADLINES:
GLOBAL HEALTH TRAVEL AWARD AUG 21, 2012
ABSTRACT & SCHOLARSHIP SEP 20, 2012
LATE-BREAKING ABSTRACT OCT 23, 2012
DISCOUNTED REGISTRATION NOV 15, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13A8
19
METABOLIC CONTROL OF
INFLAMMATION AND IMMUNITY
JANUARY 2126, 2013
BEAVER RUN RESORT, BRECKENRIDGE, COLORADO, USA
(venue information on page 27)
DEADLINES:
ABSTRACT & SCHOLARSHIP SEP 24, 2012
LATE-BREAKING ABSTRACT OCT 24, 2012
DISCOUNTED REGISTRATION NOV 19, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13A9
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A9.
Scientic Organizers: Vishva M. Dixit, Douglas R. Green and Maya Saleh
MONDAY, JANUARY 21: ARRIVAL & REGISTRATION
TUESDAY, JANUARY 22
Keynote Address
Richard A. Flavell, Yale University School of Medicine, USA
Microbiota, NLRs and the Inlammasome
Metabolism and Signaling
Ronald M. Evans, The Salk Institute, USA
PPAR and Circadian Rhythm
Matthew G. Vander Heiden, Massachusetts Institute
of Technology, USA
Talk Title to be Determined
Ajay Chawla, University of California, San Francisco, USA
Innate Control of Metabolism
Mitchell A. Lazar, University of Pennsylvania School
of Medicine, USA
PPARs, Diabetes and Inlammation
The Inlammasome and Metabolism I
Vishva M. Dixit, Genentech, Inc., USA
New Components: Caspase-11 and Beyond
Jenny P. Ting, University of North Carolina at Chapel Hill, USA
Fatty Acid-Induced NLRP3 Inlammasome Activation
Thirumala-Devi Kanneganti, St. Jude Childrens
Research Hospital, USA
Nlrp3 Inlammasome in Diabetes
Eicke Latz, University of Massachusetts Medical School, USA
The Inlammasome in Atherosclerosis
WEDNESDAY, JANUARY 23
The Inlammasome and Metabolism II
Charles A. Dinarello, University of Colorado Health
Sciences Center, USA
How Does the IL-1 Family Control its Own Members?
Luke A. J. ONeill, Trinity College Dublin, Ireland
Metabolic Control of IL-1b Signaling
Marc Y. Donath, University Hospital Basel, Switzerland
IL-1b and Diabetes
Vishwa Deep Dixit, Pennington Biomedical Research Center,
LSU System, USA
The NLRP3 Inlammasome and Obesity-Associated Co-Morbidities
Inlammation and Metabolism
Gkhan S. Hotamisligil, Harvard University, USA
Metabolism, ER Stress and Inlammation
Speaker to be Announced
Steven E. Shoelson, Harvard Medical School,
Joslin Diabetes Center, USA
Targeting Inlammation in Insulin Resistance and Diabetes
THURSDAY, JANUARY 24
NOD, Microbiota and Metabolism
Maya Saleh, McGill University, Canada
NOD-Mediated Inlammation
Stephen E. Girardin, University of Toronto, Canada
NOD2, Autophagy and Inlammation
Herbert (Skip) W. Virgin IV, Washington University School
of Medicine, USA
Autophagy in Inlammation and Disease
Gabriel Nuez, University of Michigan, USA
Inlammasome Inluence on Microbiota
Mitochondria, Inlammation and Metabolism
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Cytosolic Immune Surveillance
Speaker to be Announced
Richard M. Siegel, NIAMS, National Institutes of Health, USA
Mitochondrial ROS: Fuel for the Fire of Autoinlammation
FRIDAY, JANUARY 25
Metabolic Control of Adaptive Immunity
Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
HIF1 in the Treg/Th17 Axis
Jonathan D. Powell, Johns Hopkins University School of Medicine, USA
mTOR Regulation of T Cell Function
Douglas R. Green, St. Jude Childrens Research Hospital, USA
Metabolic Reprogramming in Activated T Cells
Jeffrey C. Rathmell, Duke University, USA
Glucose Metabolism in T Cell Activation and CD4 Subsets
Cell Death, Immunity and Metabolism
Michael Karin, University of California, San Diego, USA
NF-B, Inlammation and Metabolism
Kodi S. Ravichandran, University of Virginia, USA
Apoptotic Cell Clearance and the Phagocyte Metabolism
Nika N. Danial, Dana-Farber Cancer Institute, USA
A Role for Bcl2 Family Members in Diabetes
SATURDAY, JANUARY 26: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
20
PORTOLA HOTEL & SPA
MONTEREY, CALIFORNIA, USA
Local elevation: 40 (12 m)
Local airports/distances to venue: Monterey Penninsula (MRY)/4 mi (6 km);
San Jose International (SJC)/74 mi (119 km)
SHERATON MIYAKO HOTEL TOKYO
TOKYO, JAPAN
Local elevation: 59 (18 m)
Local airports/distances to venue: Narita International (NRT)/49 mi
(79 km); Tokyo International/Haneda (HND)/8 mi (13 km)
FAIRMONT CHTEAU LAURIER
OTTAWA, ONTARIO, CANADA
SANTA FE COMMUNITY CONVENTION CENTER
SANTA FE, NEW MEXICO, USA
BIG SKY RESORT
BIG SKY, MONTANA, USA
Local elevation: 50 (18 m)
Local airport/distance to venue: Ottawa MacDonald-Cartier (YOW)/9 mi
(15 km)
Local elevation: 7000 (2134 m)
Local airports/distances to venue: Albuquerque International Sunport
ABQ mi km Santa Fe Nunicipal SAF mi km
Local elevation: 7500 (2286 m)
Local airport/distance to venue: Bozeman Gallatin Field (BZN)/
49 mi (79 km)
FAIRMONT HOTEL VANCOUVER
VANCOUVER, BRITISH COLUMBIA, CANADA
Local elevation: 108 (33 m)
Local airport/distance to venue: Vancouver International (YVR)/9 mi
(14 km)
21
ANTIBODIES AS DRUGS
JANUARY 27FEBRUARY 1, 2013
FAIRMONT HOTEL VANCOUVER, VANCOUVER, BRITISH COLUMBIA, CANADA
(venue information on page 21)
Scientic Organizers: Paul Carter and Andreas G. Plckthun
Sponsored by Abbott Laboratories and Astellas Pharma Inc.
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J3.
JOINT WITH...
SUNDAY, JANUARY 27: ARRIVAL & REGISTRATION
Keynote Address
Jeffrey V. Ravetch, Rockefeller University, USA
Remodeling Antibody Glycans for Immunomodulation
MONDAY, JANUARY 28
Tumor Targeting From Understanding Mechanisms
to New Targeting Agents (Joint)
Karl Dane Wittrup, Massachusetts Institute of Technology, USA
Synergistic Antibody and Cytokine Effects in Cancer Immunotherapy
Kerry Chester, University College London Cancer Institute, UK
Antibody-Targeted Iron Oxide Nanoparticles for Cancer
Dario Neri, ETH Zrich, Switzerland
Armed Antibodies for Vascular Targeting
Anna M. Wu, University of California, Los Angeles, USA
Engineered Antibodies for Molecular Imaging of Cancer
Short Talk(s) Chosen from Abstracts
Workshop 1: Emerging Antibody Generation Methods
Short Talks Chosen from Abstracts
Payloaded Antibodies for Cancer Treatment
Peter D. Senter, Seattle Genetics Inc., USA
Antibody-Drug Conjugates with Auristatins: From ADC Optimization
to a Clinically Approved Drug and Beyond
John M. Lambert, ImmunoGen, Inc., USA
Antibody-Drug Conjugates with Maytansinoids
Paul G. Polakis, Genentech, Inc., USA
Target Selection for Antibody-Drug Conjugates
Short Talk Chosen from Abstracts
TUESDAY, JANUARY 29
Antibodies in Infectious Diseases
Antonio Lanzavecchia, Institute for Research
in Biomedicine, Switzerland
Human Antibodies to Infectious Disease Targets
Dennis R. Burton, The Scripps Research Institute, USA
HIV Reverse Vaccinology
Gary J. Nabel, NIAID, National Institutes of Health, USA
Broadly Neutralizing Antibodies to HIV
Erica Ollmann Saphire, The Scripps Research Institute, USA
Antibodies Against Ebola
Short Talk(s) Chosen from Abstracts
New Technologies for Generating Proteins
with Novel Functions
David Baker, University of Washington, USA
Computational Design/Redesign of Proteins
Speaker to be Announced
Julia Shifman, Hebrew University of Jerusalem, Israel
Computational Design of Protein-Protein Interactions
Short Talk Chosen from Abstracts
WEDNESDAY, JANUARY 30
Bispeciic and Multispeciic Targeting Agents
Carlos F. Barbas III, The Scripps Research Institute, USA
Multifunctional and Multispeciic Antibodies: New Strategies and Activities
Kaspar H. Binz, Molecular Partners, Switzerland
Exploiting Novel Therapeutic Mechanisms Using Multi-Speciic DARPins
James D. Marks, University of California, San Francisco, USA
Antibody Combinations for Treatment of Botulism
Lutz Jermutus, MedImmune Ltd, UK
Bispeciic Antibodies from Phenotypic Selections Targeting
Pseudomonas aeruginosa
Short Talk(s) Chosen from Abstracts
Workshop 2: Enhancing Effector Functions
and Extending Half-Life
Short Talks Chosen from Abstracts
Modulating the Activity of Growth Factor Receptors
Andreas G. Plckthun, University of Zurich, Switzerland
New Approaches to Receptor Antagonism
Ermanno Gherardi

, Medical Research Council Laboratory


of Molecular Biology, UK
Met Biology and Structural Biochemistry
Thi-Sau Migone, Human Genome Sciences, USA
Belimumab A Human MAb Against BLys for the Treatment of SLE
Short Talk Chosen from Abstracts
THURSDAY, JANUARY 31
Immunmodulatory Antibody Therapies (Joint)
Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA
PD-1 Blockade in Cancer Therapy
Nils Lonberg, Bristol-Myers Squibb, USA
Development Hurdles for Immuno-Oncology Antibody Drugs
Patrick A. Baeuerle, Micromet GmbH, Germany
Cancer Therapy by Bispeciic, T Cell-Engaging Antibodies
Speaker to be Announced
Challenges and New Opportunities with Antibody Drugs
Ryan J. Watts, Genentech, Inc., USA
Bispeciic Antibodies to Deliver Therapeutics across
the Blood-Brain Barrier
Leo James, University of Cambridge, UK
Intracellular Immunity and TRIM21
Erkki Ruoslahti, Sanford-Burnham Medical Research Institute, USA
Increasing Extravasation with Peptides
Short Talk Chosen from Abstracts
FRIDAY, FEBRUARY 1: DEPARTURE

Invited, not yet accepted


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
22
CANCER IMMUNOLOGY
AND IMMUNOTHERAPY
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J4.
DEADLINES FOR BOTH CONFERENCES:
ABSTRACT & SCHOLARSHIP SEP 25, 2012
LATE-BREAKING ABSTRACT OCT 25, 2012
DISCOUNTED REGISTRATION NOV 27, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13J3 or /13J4
Scientic Organizers: Glenn Dranoff, Carl H. June and Suzanne L. Topalian
Sponsored by Bayer USA Foundation
Registering for one conference in a set of joint conferences enables
participation in sessions of the other, pending space availability.
SUNDAY, JANUARY 27: ARRIVAL & REGISTRATION
Keynote Address
James P. Allison, Memorial Sloan-Kettering Cancer Center, USA
Checkpoint Blockade
MONDAY, JANUARY 28
Tumor Targeting From Understanding Mechanisms
to New Targeting Agents (Joint)
Karl Dane Wittrup, Massachusetts Institute of Technology, USA
Synergistic Antibody and Cytokine Effects in Cancer Immunotherapy
Kerry Chester, University College London Cancer Institute, UK
Antibody-Targeting Iron Oxide Nanoparticles from Cancer
Dario Neri, ETH Zrich, Switzerland
Armed Antibodies for Vascular Targeting
Anna M. Wu, University of California, Los Angeles, USA
Engineered Antibodies for Molecular Imaging of Cancer
Short Talk(s) Chosen from Abstracts
Tumor Microenvironment
Wolf-Herman Fridman, Hpital Europen Georges-Pompidou, France
The Immune Microenvironment of Primary and Metastatic
Human Tumors
Robert D. Schreiber, Washington University School of Medicine, USA
Cancer Immunoediting Mechanisms and Therapeutic Opportunities
Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
Inlammation and Cancer
Short Talk Chosen from Abstracts
TUESDAY, JANUARY 29
Engineering and Immunotherapy
David J. Mooney, Harvard University, USA
Polymer Scaffolds for Immunotherapy
Darrell J. Irvine, Massachusetts Institute of Technology, USA
Nanoparticles for Cellular Therapy
Carl H. June, University of Pennsylvania, USA
Engineered T Cells for Adoptive Therapy
Laurence J.N. Cooper, University of Texas MD Anderson
Cancer Center, USA
Sleeping Beauty Transposase for Engineered T Cells
Short Talk(s) Chosen from Abstracts
Cancer Vaccines
Cornelis J. M. Melief, Leiden University Medical Center, Netherlands
Long Peptides
Cornelia L. Trimble, Johns Hopkins University School
of Medicine, USA
Talk Title to be Determined
Speaker to be Announced
Short Talk Chosen from Abstracts
WEDNESDAY, JANUARY 30
Adoptive Cellular Therapy
Stanley R. Riddell, Fred Hutchinson Cancer Research Center, USA
T Cell Subsets in Adoptive Therapy
Nicholas P. Restifo, NCI, National Institutes of Health, USA
Self-Renewal and Persistence of T Cell Subsets
Catherine M. Bollard, Baylor College of Medicine, USA
Adoptive T Cell Therapy Moving Beyond Phase I Studies
Robert S. Negrin, Stanford University, USA
Allogenic Bone Marrow Transplantation
Short Talk(s) Chosen from Abstracts
Metabolism and Cancer
Laurence Zitvogel, Institut Gustave Roussy, France
ATP and Tumor Cell Immunogenicity
Vincenzo Bronte, University of Verona, Italy
Myeloid Suppressive Mechanisms
George C. Prendergast, Lankenau Institute for Medical Research, USA
IDO/IDO2 Genetics and Therapeutic Correction of the IDO Pathway
Short Talk Chosen from Abstracts
THURSDAY, JANUARY 31
Immunomodulatory Antibody Therapies (Joint)
Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA
PD-1 Blockade in Cancer Therapy
Nils Lonberg, Bristol-Myers Squibb, USA
Development Hurdles for Immuno-Oncology Antibody Drugs
Patrick A. Baeuerle, Micromet GmbH, Germany
Cancer Therapy by Bispeciic, T Cell-Engaging Antibodies
Speaker to be Announced
Short Talk(s) Chosen from Abstracts
Anti-Cancer Antibodies
George J. Weiner, University of Iowa, USA
Therapeutic Mechanisms of Monoclonal Antibodies
Mark J. Smyth, Peter MacCallum Cancer Centre, Australia
Monoclonal Antibody-Based Combinatorial Therapies
Glenn Dranoff, Dana-Farber Cancer Institute, USA
Therapy-Induced Antibody Responses
Short Talk Chosen from Abstracts
FRIDAY, FEBRUARY 1: DEPARTURE

Invited, not yet accepted


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
23
ADIPOSE TISSUE BIOLOGY
JANUARY 27FEBRUARY 1, 2013
KEYSTONE RESORT, KEYSTONE, COLORADO, USA
(venue information on page 45)
Scientic Organizers: Susan K. Fried and Anthony W. Ferrante
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J5.
JOINT WITH...
SUNDAY, JANUARY 27: ARRIVAL & REGISTRATION
MONDAY, JANUARY 28
Keynote Address (Joint)
Craig B. Thompson, Memorial Sloan-Kettering Cancer Center, USA
Metabolic Regulation in Cancer Biology
Mechanisms of Metabolic Dysfunction and New
Therapeutic Targets for Diabetes (Joint)
Bruce M. Spiegelman, Harvard Medical School, USA
PPAR Non-Agonists as Anti-Diabetic Therapy
David J. Mangelsdorf, University of Texas Southwestern
Medical Center, USA
FGF-19 in Metabolic Control
Michael R. Jirousek, Catabasis Pharmaceuticals, Inc., USA
Dual-Action Anti-Inlammatory Insulin Sensitizers
Workshop 1: Measurement of Mitochondrial Function
in vitro and in vivo
Short Talks Chosen from Abstracts
Losing Fat: Dynamics of Adipocyte Lipid Turnover
Rudolf Zechner, University of Graz, Austria
Molecular Regulation of Lipolysis
Paul F. Pilch, Boston University School of Medicine, USA
Caveolins and Lipolysis
Richard N. Bergman, Cedars-Sinai Medical Center, USA
Physiology: Oscillations in Adipocyte Lipolysis
Short Talk Chosen from Abstracts
TUESDAY, JANUARY 29
Remodeling a Healthy Adipose Tissue
Silvia Corvera, University of Massachusetts Medical School, USA
Feeding Fat and Vascular Remodeling
Rajat Singh, Albert Einstein College of Medicine, USA
When Fat Is Self-Absorbed Autophagy and Lipid Metabolism
Chad A. Cowan, Harvard University, USA
Adipocyte Ontogeny and Turnover
Speaker to be Announced
Short Talk(s) Chosen from Abstracts
Epigenetics and Perinatal Imprinting in Diabetes
and Obesity (Joint)
C. Ronald Kahn, Joslin Diabetes Center
and Harvard Medical School, USA
Diabetes and Obesity Nature vs. Nurture
Anne Ferguson-Smith, University of Cambridge, UK
Mechanisms of Genetic Imprinting
Paolo Sassone-Corsi, University of California, Irvine, USA
Epigenetic Control of Circadian Rhythms and Metabolism
WEDNESDAY, JANUARY 30
Signaling Defects and Inlammation
in Insulin Resistance (Joint)
Diane J. Mathis, Harvard Medical School, USA
T-Cell Function in Adipose Tissue Depots
Anthony W. Ferrante, Columbia University, USA
Macrophages in Insulin Resistance
Ruslan M. Medzhitov, Yale University School of Medicine, USA
Inlammation and Metabolism
Ajay Chawla, University of California, San Francisco, USA
Innate Control of Metabolism
Workshop 2: Assessing Immune Cell Populations
in Adipose Tissue: What Are the FACS?
Short Talks Chosen from Abstracts
Variation in the Biology of Adipose Depots
Susan K. Fried, Boston Medical Center, USA
Genes Regulating Fat Distribution in Men and Women
James L. Kirkland, Mayo Clinic, USA
Cellular Senescence and Adipocyte Tissue
Speaker to be Announced
Short Talk Chosen from Abstracts
THURSDAY, JANUARY 31
Brown Adipose Tissue: Where There Is Smoke...
Stephen R. Farmer, Boston University School of Medicine, USA
Brite Fat-Molecular Mechanisms
Sheila Collins, Sanford-Burnham Medical Research Institute, USA
Converging Hormonal Signals that Spark the Brown-in-White
Adipocyte Transformation
Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA
Developmental Control of Brown Adipose Tissue
Short Talks Chosen from Abstracts
Beyond Diabetes Complications of Obesity
Kathryn J. Moore, New York University Medical Center, USA
Atherosclerosis and Lipid Metabolism
Mikhail G. Kolonin, University of Texas, USA
Regulation of Tumor Progression by Adipose Tissue
Speaker to be Announced
Short Talk Chosen from Abstracts
FRIDAY, FEBRUARY 1: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
24
DIABETES NEW INSIGHTS
INTO MECHANISM OF DISEASE
AND ITS TREATMENT
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J6.
DEADLINES FOR BOTH CONFERENCES:
ABSTRACT & SCHOLARSHIP SEP 27, 2012
LATE-BREAKING ABSTRACT OCT 29, 2012
DISCOUNTED REGISTRATION NOV 28, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13J5 or /13J6
Scientic Organizers: C. Ronald Kahn, Jens C. Brning and Gerald I. Shulman
Sponsored by MedImmune
Registering for one conference in a set of joint conferences enables
participation in sessions of the other, pending space availability.
SUNDAY, JANUARY 27: ARRIVAL & REGISTRATION
MONDAY, JANUARY 28
Keynote Address (Joint)
Craig B. Thompson, Memorial Sloan-Kettering Cancer Center, USA
Metabolic Regulation in Cancer Biology
Mechanisms of Metabolic Dysfunction and New
Therapeutic Targets for Diabetes (Joint)
Bruce M. Spiegelman, Harvard Medical School, USA
PPAR Non-Agonists as Anti-Diabetic Therapy
David J. Mangelsdorf, University of Texas Southwestern
Medical Center, USA
FGF-19 in Metabolic Control
Michael R. Jirousek, Catabasis Pharmaceuticals, Inc., USA
Dual-Action Anti-Inlammatory Insulin Sensitizers
miRNAs and Metabolic Disease
Markus Stoffel, Institute of Molecular Systems Biology, Switzerland
miRNAs in Control of -Cell Function
Jens C. Brning, Institute for Genetics, University of Cologne, Germany
miRNAs in Control of Liver Metabolism
Anna Krook, Karolinska Institutet, Sweden
Role of miRNA Let7 in Diabetes-Related Inlammation
TUESDAY, JANUARY 29
Aging, Mitochondria and Control of Metabolism
Andrew G. Dillin, The Salk Institute for Biological Studies, USA
Humoral Control of Mitochondrial Form and Function
Kitt F. Petersen, Yale University School of Medicine, USA
Altered Mitochondrial Function in Muscle in Aging and Disease
Eric M. Verdin, University of California, San Francisco, USA
Reversible Acetylation in Regulation of Mitochondrial Function
and Aging
Domenico Accili, Columbia University, USA
Talk Title to be Determined
Epigenetics and Perinatal Imprinting in Diabetes
and Obesity (Joint)
C. Ronald Kahn, Joslin Diabetes Center
and Harvard Medical School, USA
Diabetes and Obesity Nature vs. Nurture
Anne Ferguson-Smith, University of Cambridge, UK
Mechanisms of Genetic Imprinting
Paolo Sassone-Corsi, University of California, Irvine, USA
Epigenetic Control of Circadian Rhythms and Metabolism
WEDNESDAY, JANUARY 30
Signaling Defects and Inlammation
in Insulin Resistance (Joint)
Diane J. Mathis, Harvard Medical School, USA
T-Cell Function in Adipose Tissue Depots
Anthony W. Ferrante, Columbia University, USA
Macrophages in Insulin Resistance
Ruslan M. Medzhitov, Yale University School of Medicine, USA
Inlammation and Metabolism
Ajay Chawla, University of California, San Francisco, USA
Innate Control of Metabolism
Gastric Bypass Surgery and the Gut
in Control of Metabolism
David E. Cummings, University of Washington, USA
Metabolic Surgery: Endocrine Mechanisms of Diabetes Remission
after Bariatric Operations
Jin-Long Chen, NGM Biopharmaceuticals, Inc., USA
New Gut Mediators of Bypass Surgery
Lee M. Kaplan, Massachusetts General Hospital, USA
Physiological Responses to Bariatric Surgery
THURSDAY, JANUARY 31
Metabolic Mediators of Insulin Resistance
Philipp E. Scherer, University of Texas Southwestern Medical
Center, USA
Ceramides as Mediators of Insulin Resistance
Gerald I. Shulman, HHMI/Yale University School of Medicine, USA
Novel PKCs as Mediators of Insulin Resistance
Gkhan S. Hotamisligil, Harvard University, USA
ER Stress as a Mediator of Insulin Resistance
Reuben J. Shaw, The Salk Institute, USA
AMPK Signaling Modulates Insulin Resistance
CNS Control of Metabolism
Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
CNS Control of Energy Balance and Peripheral Metabolism
Christoph Buettner, Mount Sinai School of Medicine, USA
Brain Control of Adipose Tissue Metabolism
Richard M. Caprioli, Vanderbilt University Medical Center, USA
Molecular Imaging of Tissue by Mass Spectrometry:
Looking Beyond the Microscope
FRIDAY, FEBRUARY 1: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
25
MITOCHONDRIA, METABOLISM AND
MYOCARDIAL FUNCTION BASIC ADVANCES
TO TRANSLATIONAL STUDIES
FEBRUARY 38, 2013
KEYSTONE RESORT, KEYSTONE, COLORADO, USA
(venue information on page 45)
DEADLINES:
ABSTRACT & SCHOLARSHIP OCT 3, 2012
LATE-BREAKING ABSTRACT OCT 31, 2012
DISCOUNTED REGISTRATION DEC 3, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13B1
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B1.
Scientic Organizers: Michael N. Sack and Roberta Gottlieb
SUNDAY, FEBRUARY 3: ARRIVAL & REGISTRATION
MONDAY, FEBRUARY 4
Keynote Address
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Autophagy in Cellular Energy Balance
The Biology of Mitochondrial Homeostatic Regulatory
Programs and Cardiac Disease
Roberta Gottlieb, San Diego State University, USA
The Role of Mitophagy in Mitochondrial Biogenesis
Orian S. Shirihai, Boston University, USA
The Interplay between Mitochondrial Dynamics and Autophagy
Kinya Otsu, Osaka University, Japan
Mitochondrial DNA in the Development of Cardiac Inlammation
and Dysfunction
Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Autophagy and the Failing Heart
Short Talk Chosen from Abstracts
Regulation of Redox Stress in Cardiovascular Disease
Junichi Sadoshima, University of Medicine and Dentistry
of New Jersey, USA
The Role of NADPH Oxidases in Mediating Oxidative Stress
in Mitochondria
Gerald S. Shadel, Yale University, USA
Mitochondrial ROS Signaling in Disease and Aging
Jeffery D. Molkentin

, Cincinnati Children's Hospital


Medical Center, USA
Novel Pathways to Augment ER Stress Protection in the Heart
Short Talk Chosen from Abstracts
TUESDAY, FEBRUARY 5
Metabolic Modulation in the Pathogenesis and Treatment
of Cardiac Hypertrophy and Heart Failure
Jan F. Glatz, Maastricht University, Netherlands
Novel Signaling Pathways Regulating Substrate Switching in the Heart
Martin E. Young, University of Alabama at Birmingham, USA
The Circadian Clock, Metabolic Regulation and Cardiac Pathology
Gary D. Lopaschuk, University of Alberta, Canada
Modulation of Malonyl-CoA and Cardiac Metabolic Consequences
William C. Stanley, University of Maryland, USA
Mitochondrial Pathology in Heart Failure: Novel Therapeutic Approaches
Short Talk(s) Chosen from Abstracts
Emerging Regulatory Programs in the Control
of Mitochondria and Metabolism
Elizabeth Murphy, NHLBI, National Institutes of Health, USA
S-nitrosylation in the Control of Mitochondrial Stress Response
Michael N. Sack, NHLBI, National Institutes of Health, USA
Mitochondrial Protein Acetylation and the Control
of Mitochondrial Metabolism
Eric N. Olson, University of Texas Southwestern Medical Center, USA
The Role of MED13 in Regulating Cardiac Mitochondrial Metabolism
and Systemic Insulin Resistance
Short Talk Chosen from Abstracts
WEDNESDAY, FEBRUARY 6
Nutrient Stressors and the Modulation
of Cardiovascular Function
Gkhan S. Hotamisligil, Harvard University, USA
ER Stress, Obesity and Atherosclerosis
E. Dale Abel, University of Utah School of Medicine, USA
Obesity-Mediated Disruption of Cardiac Mitochondrial Function
Jason Dyck, University of Alberta, Canada
Caloric Restriction and Cardiovascular Function
Daniel P. Kelly, Sanford-Burnham Medical Research Institute, USA
Myocyte Lipotoxicity Screening to Delineate Mechanisms and Drug Targets
Short Talk(s) Chosen from Abstracts
Emerging Technologies to Characterize Mitochondrial
and Metabolic Functioning
Robert S. Balaban, NHLBI, National Institutes of Health, USA
Systems Biology of Mitochondria
Peipei Ping, University of California, Los Angeles, USA
Metabolic Lessons from Unbiased Large-Scale Proteomic Studies
Christopher B. Newgard, Duke University Medical Center, USA
Metabolomics Applied to Cardiovascular Diseases
Short Talk Chosen from Abstracts
THURSDAY, FEBRUARY 7
Novel Programs Controlling Mitochondria and Metabolism
Vamsi K. Mootha, Massachusetts General Hospital, USA
Identiication of the Mitochondrial Calcium Uniporter
Christine Des Rosiers, Montreal Heart Institute (MHI), Canada
Metabolomics: What Have We Learned from Heart Failure Patients?
Johan Auwerx, cole Polytechnique Fdrale de Lausanne (EPFL),
Switzerland
Transcriptional Corepressors in the Control of Mitochondrial Homeostasis
Thomas Langer, University of Cologne, Germany
Quality Control of Mitochondrial Proteostasis
Short Talk(s) Chosen from Abstracts
Clinical Studies to Advance Biological Insight
and Therapeutic Targets
Lawrence Young, Yale University, USA
AMPK and the Modulation of Mitochondrial Function
Patrick Schrauwen, Maastricht University, Netherlands
Lipotoxicity, Mitochondria and Cardiac Function:
Insight from Human Clinical Intervention Studies
Anthony J. Muslin, Novartis Institutes for BioMedical Research, Inc., USA
Modulation of Signaling Pathways to Treat Cardiovascular Disease
Short Talk Chosen from Abstracts
FRIDAY, FEBRUARY 8: DEPARTURE

Invited, not yet accepted.


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
26
SNOWBIRD RESORT
SNOWBIRD, UTAH, USA
Local elevation: 8150 (2484 m)
Local airport/distance to venue: Salt Lake City International (SLC)/
32 mi (52 km)
SHERATON STEAMBOAT RESORT
STEAMBOAT SPRINGS, COLORADO, USA
SAGEBRUSH INN & CONFERENCE CENTER
TAOS, NEW MEXICO, USA
GRANLIBAKKEN RESORT
TAHOE CITY, CALIFORNIA, USA
Local elevation: 6900 (2103 m)
Local airports/distances to venue: Yampa Valley Regional (HDN)/27 mi
(43 km); Denver International (DEN)/178 mi (286 km)
Local elevation: 6950 (2118 m)
Local airports/distances to venue: Albuquerque International Sunport
ABQ mi km Santa Fe Nunicipal SAF mi km
Local elevation: 6900 (2103 m)
Local airport/distance to venue: Reno/Tahoe International (RNO)/
52 mi (84 km)
JW MARRIOTT NEW ORLEANS
NEW ORLEANS, LOUISIANA, USA
Local elevation: 1 (0.3 m)
Local airport/distance to venue: Louis Armstrong New Orleans
International (MSY)/13 mi (21 km)
BEAVER RUN RESORT
BRECKENRIDGE, COLORADO, USA
Local elevation: 9600 (2926 m)
Local airport/distance to venue: Denver International (DEN)/
100 mi (161 km)
27
NEUROGENESIS
FEBRUARY 38, 2013
SANTA FE COMMUNITY CONVENTION CENTER, SANTA FE, NEW MEXICO, USA
(venue information on page 21)
Scientic Organizers: Hongjun Song, Yukiko Gotoh, Yi Eve Sun and Gerd Kempermann
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J7.
JOINT WITH...
SUNDAY, FEBRUARY 3: ARRIVAL & REGISTRATION
MONDAY, FEBRUARY 4
Keynote Address
Fred H. Gage, The Salk Institute for Biological Studies, USA
Neurogenesis and Neurological Disorders: Lessons from Studies
of Adult Neurogenesis and Patient-Derived iPSCs
Neurogenesis and Gliogenesis
Gordon J. Fishell, New York University Medical Center, USA
The Role of Genetics and Activity in the Generation
of Cortical Neuron Subtypes
Jonas Frisn, Karolinska Institutet, Sweden
Gliogenesis in Postnatal CNS
Dwight E. Bergles, Johns Hopkins University School of Medicine, USA
NG2+ OPCs and Role in ALS
Patrik Ernfors, Karolinska Institutet, Sweden
Cell Type Speciiciation in the Neural Crest
Short Talk Chosen from Abstracts
Model Systems
Tzumin Lee, HHMI/Janelia Farm Research Campus, USA
Lineage Analysis with Twin-Spot MARCM in Drosophila
Arnold Kriegstein, University of California, San Francisco, USA
oSVZ Neurogenesis in Developing Mouse and Human Cortex
Su-Chun Zhang, University of Wisconsin-Madison, USA
Generation of Diverse Neural Subtypes from Pluripotent
Human Stem Cells
Short Talk Chosen from Abstracts
TUESDAY, FEBRUARY 5
Neurogenesis and Development: Molecular Mechanisms
Yukiko Gotoh, University of Tokyo, Japan
Regulation of Neural Stem/Progenitor Cell Fate
during Mouse Development
Soo-Kyung Lee, Oregon Health & Science University, USA
Gene Regulatory Networks in Spinal Cord Neurogenesis
Francois Guillemot, National Institute for Medical Research, UK
Transcriptional Control of Stem Cell Fates in the Embryonic
and Adult Brain
Jenny Hsieh, University of Texas Southwestern Medical Center, USA
Signaling Mechanism in Adult Neurogenesis
Short Talk(s) Chosen from Abstracts
Stem Cell Niches in the Developing and Adult Brain
Christopher A. Walsh, Childrens Hospital Boston, USA
Niche for Embryonic Cortical Neurogenesis
Andrea Brand, University of Cambridge, UK
Nutrient Control of Neural Stem Cells
Chay T. Kuo, Duke University Medical Center, USA
Sustaining New Neuron Production in the SVZ Niche
Short Talk Chosen from Abstracts
WEDNESDAY, FEBRUARY 6
Epigenetics and Genomics (Joint)
Yi Eve Sun, University of California, Los Angeles, USA
DNA Methylome during Developmental Neurogenesis
Andr Fischer, European Neuroscience Institute Gttingen, Germany
Histone Modiications in Degenerative Neurological Disorders
Daniel H. Geschwind, University of California, Los Angeles, USA
Functional Genomic Analyses of Pathways Dysregulated
in Frontal Temporal Dementia
Hongjun Song, Johns Hopkins University School of Medicine, USA
Activity-Induced Modiication of Neuronal DNA Methylome
Short Talk(s) Chosen from Abstracts
Adult Neurogenesis: Regulation and Functions
Gerd Kempermann, Technische Universitt Dresden, Germany
Systems Biology of Adult Neurogenesis and its Function
Pierre-Marie Lledo, Pasteur Institute, France
Adult Neurogenesis and Olfaction
Shaoyu Ge, SUNY Stony Brook, USA
Optogenetic Probing of Adult Neurogenesis Function
Short Talk Chosen from Abstracts
THURSDAY, FEBRUARY 7
Adult Neurogenesis under Pathological Conditions
Xinyu Zhao, University of Wisconsin, USA
Adult Neurogenesis and Fragile X Syndrome
Heather A. Cameron, NIMH, National Institutes of Health, USA
Adult Neurogenesis, Stress and Depression
Randall Reed, Johns Hopkins University, USA
Olfactory Epithelium Neurogenesis after Injury
Jack M. Parent, University of Michigan, USA
Adult Neurogenesis after Injury
Short Talk(s) Chosen from Abstracts
iPSC Modeling of Developmental and Degenerative
Neurological Diseases (Joint)
Guo-li Ming, Johns Hopkins University, USA
iPSCs Derived from Schizophrenia Patients with a DISC1 Mutation
Anirvan Ghosh, Hoffmann-La Roche, Switzerland
Small Molecule Screen of hESCs and Patient-Derived iPSCs
Kevin C. Eggan, Harvard University, USA
Modeling ALS Using iPSCs
Short Talk Chosen from Abstracts
FRIDAY, FEBRUARY 8: DEPARTURE

This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
28
NEW FRONTIERS
IN NEURODEGENERATIVE
DISEASE RESEARCH
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J8.
DEADLINES FOR BOTH CONFERENCES:
ABSTRACT & SCHOLARSHIP OCT 4, 2012
LATE-BREAKING ABSTRACT NOV 1, 2012
DISCOUNTED REGISTRATION DEC 4, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13J7 or /13J8
Scientic Organizers: Li-Huei Tsai, Steven M. Paul and Michael Hutton
Sponsored by Vertex Pharmaceuticals Incorporated
Registering for one conference in a set of joint conferences enables
participation in sessions of the other, pending space availability.
SUNDAY, FEBRUARY 3: ARRIVAL & REGISTRATION
MONDAY, FEBRUARY 4
Keynote Address
Susan Lindquist, HHMI/Whitehead Institute
for Biomedical Research, USA
Modeling Pathology in Simpler Cells
Protein Aggregation and Propagation of Misfolded Proteins
in the Brain
Virginia M. Y. Lee, University of Pennsylvania School of Medicine, USA
Protein Aggregation in Alzheimers Disease and Frontal
Temporal Dementia
John Collinge, Institute of Neurology, University College London, UK
Prion Disease
Mathias Jucker, Universitt Tbingen, Germany
Propagation of Misfolded Proteins in the Brain
Jeffery W. Kelly, The Scripps Research Institute, USA
Strategies to Ameliorate Neurodegenerative Diseases by Adapting
the Proteostasis Network
Short Talk Chosen from Abstracts
Mechanisms of Early Disease Intervention and Biomarkers
John Q. Trojanowski, University of Pennsylvania, USA
Alzheimers Biomarkers and Tau-Focused Therapies
Ronald B. DeMattos, Lilly Research Laboratories, USA
The Use of Biomarkers in the Development of AD Therapies
Rosa Rademakers, Mayo Clinic, USA
Frontal Temporal Dementia and Amyotrophic Lateral Sclerosis
Short Talk Chosen from Abstracts
TUESDAY, FEBRUARY 5
Molecular Mechanisms of Neuronal Vulnerability
Myriam Heiman, Massachusetts Institute of Technology, USA
TRAPping Parkinsons and Huntingtons Diseases
Michael R. Hayden, University of British Columbia, Canada
Huntingtons Disease
Valina L. Dawson, Johns Hopkins University School of Medicine, USA
Mechanisms of Cell Death in Neurodegeneration
Steven M. Paul, Weill Cornell Medical College, USA
ApoE, Amyloid Deposition and A Clearance
Short Talk(s) Chosen from Abstracts
Novel Approaches for the Therapeutic Intervention
of Neurodegenerative Disease
Anders Bjorklund, Lund University, Sweden
Blockade of -Synuclein-Induced Neurodegeneration by Gene
Therapy Approaches
Ryan J. Watts, Genentech, Inc., USA
Targeting Neurodegeneration by Boosting Antibody Uptake in Brain
Michael Hutton, Lilly UK, UK
Clearance of Tau
Short Talk Chosen from Abstracts
WEDNESDAY, FEBRUARY 6
Epigenetics and Genomics (Joint)
Yi Eve Sun, University of California, Los Angeles, USA
DNA Methylome during Developmental Neurogenesis
Andr Fischer, European Neuroscience Institute Gttingen, Germany
Histone Modiications in Degenerative Neurological Disorders
Daniel H. Geschwind, University of California, Los Angeles, USA
Functional Genomic Analyses of Pathways Dysregulated
in Frontal Temporal Dementia
Hongjun Song, Johns Hopkins University School of Medicine, USA
Activity-Induced Modiication of Neuronal DNA Methylome
Short Talk(s) Chosen from Abstracts
Aging and Genome Integrity
Bruce A. Yankner, Harvard Medical School, USA
DNA Damage in Aging and Neurodegenerative Disorders
Peter J. McKinnon, St. Jude Childrens Research Hospital, USA
Defective DNA Damage Signaling and Neurodegeneration
Li-Huei Tsai, Massachusetts Institute of Technology, USA
Genome Integrity, Chromatin Remodeling
and Neurodegenerative Disorders
Short Talk Chosen from Abstracts
THURSDAY, FEBRUARY 7
Neurobiology of Disease
David M. Holtzman, Washington University, USA
Regulation of -Amyloid by Neuronal Activity
Ted M. Dawson, Johns Hopkins School of Medicine, USA
Molecular Basis of Parkinsons Disease
Li Gan, University of California, San Francisco, USA
Adult Stem Cells in Aging and Neurodegenerative Disorders
Marc Tessier-Lavigne, Rockefeller University, USA
Axon Degeneration in Development and Disease
Short Talk(s) Chosen from Abstracts
iPSC Modeling of Developmental and Degenerative
Neurological Diseases (Joint)
Guo-li Ming, Johns Hopkins University, USA
iPSCs Derived from Schizophrenia Patients with a DISC1 Mutation
Anirvan Ghosh, Hoffmann-La Roche, Switzerland
Small Molecule Screen of hESCs and Patient-Derived iPSCs
Kevin C. Eggan, Harvard University, USA
Modeling ALS Using iPSCs
Short Talk Chosen from Abstracts
FRIDAY, FEBRUARY 8: DEPARTURE

This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
29
LUNG DEVELOPMENT, CANCER
AND DISEASE
FEBRUARY 510, 2013
SAGEBRUSH INN AND CONFERENCE CENTER, TAOS,
NEW MEXICO, USA (venue information on page 27)
DEADLINES:
ABSTRACT & SCHOLARSHIP OCT 8, 2012
LATE-BREAKING ABSTRACT NOV 5, 2012
DISCOUNTED REGISTRATION DEC 5, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13B2
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B2.
TUESDAY, FEBRUARY 5: ARRIVAL & REGISTRATION
WEDNESDAY, FEBRUARY 6
Keynote Address
Anton J.M. Berns, Netherlands Cancer Institute, Netherlands
Cell of Origin of Lung Cancer
Lung Development
Mark A. Krasnow, Stanford University School of Medicine, USA
Genetic Dissection of Lung Development and Disease
James M. Wells, Cincinnati Childrens Hospital Research
Foundation, USA
Speciication and Patterning of Foregut Endoderm
Xin Sun, University of Wisconsin, USA
Branching Morphogenesis of the Lung
Emma Rawlins, University of Cambridge, UK
Multipotent Epithelial Progenitor Cells in the Developing Lung
Short Talk Chosen from Abstracts
Workshop 1: Lung Cell Replacement
Short Talks Chosen from Abstracts
Speciication, Differentiation and Patterning of Airway
Epithelial Cell Lineages
Jeffrey A. Whitsett, Cincinnati Childrens Hospital Medical Center, USA
Transcription Factors in Lung Development and Disease
Eszter Katalin Vladar, Stanford University School of Medicine, USA
Mechanisms Regulating Epithelial Planar Cell Polarity
in the Developing Lung
John F. Engelhardt, University of Iowa, USA
Development and Maintenance of the Submucosal Gland Stem/
Progenitor Cell Niche
Short Talk Chosen from Abstracts
THURSDAY, FEBRUARY 7
Lung Cancer and COPD
David M. Ornitz, Washington University School of Medicine, USA
FGF Signaling Pathways in Lung Development and Cancer
Christin S. Kuo, Stanford University, USA
Neuroendocrine Cell Development and Small Cell Lung Cancer
Speaker to be Announced
Avrum Spira, Boston University, USA
The Airway Field of Injury in Lung Cancer and COPD
Short Talk(s) Chosen from Abstracts
Lung Mesodermal Lineages and Vascularization
Patrick E. Bogard, Stanford University School of Medicine, USA
Development and the Lung Vasculature
Maya Kumar, Stanford University, USA
Embryonic Origin of Mesodermal Lineages in the Lung
Bruce C. Trapnell, University of Cincinnati College of Medicine, USA
GM-CSF, Lung Macrophages and PAP
Short Talk Chosen from Abstracts
FRIDAY, FEBRUARY 8
Alveolar Development, Vascular Remodeling
and Alveolar Disease
Tushar Desai, Stanford University, USA
Lung Adenocarcinoma and Alveolar Remodeling
Daniel B. Rikin, New York University, USA
TGF- Signaling, Extracellular Matrix and Lung Development
Mark Looney, University of California, San Francisco, USA
Real-Time Imaging of Cell Traficking in Lung Alveoli
Vladimir V. Kalinichenko, Cincinnati Childrens Hospital
Medical Center, USA
Transcriptional Regulation of Endothelial Cells during Lung Development
and Alveolar Disease
Short Talk(s) Chosen from Abstracts
Workshop 2: Models of Injury and Repair in the Lung:
Basic Science and Novel Therapeutics
Short Talks Chosen from Abstracts
Lung Progenitor Cells and Lung Disease
Brigid L.M. Hogan, Duke University Medical Center, USA
Airway Stem Cells
Frank McKeon, A

STAR/Harvard Medical School, USA


Lung Regeneration
Henry Danahay, Novartis Institutes for BioMedical Research, UK
Regulation of Cell Fate Decisions in the Airway
Short Talk Chosen from Abstracts
SATURDAY, FEBRUARY 9
Lung and Tissue Fibrosis
Christine Kim Garcia, University of Texas Southwestern Medical
Center, USA
Cellular Stress and Lung Fibrosis
Andreas Gnther, University of Giessen Lung Center, Germany
Signaling Mechanisms in Lung Fibrosis
Jeremy S. Dufield, University of Washington, USA
Pericytes and Tissue Fibrosis
Steven R. Ledbetter, Genzyme Corporation, USA
TGF- Signaling in Chronic Disease
Short Talk(s) Chosen from Abstracts
New Insights from Genetic Analysis of Rare Lung Diseases
Enid R. Neptune, Johns Hopkins University, USA
Cellular Mechanisms Associated with Cutis laxa, Fibulins,
TGF- and Lung Disease
Speaker to be Announced
Esteban Carlos DellAngelica, University of California, Los Angeles, USA
Molecular Basis of Hermansky-Pudlak Syndrome
Short Talk Chosen from Abstracts
SUNDAY, FEBRUARY 10: DEPARTURE

This conference will also feature poster sessions, providing excellent opportunities to
network and discuss your research. Submit your abstract online by the deadlines listed
above for the chance to present during one of these poster sessions, or a plenary session
or workshop.
30
Scientic Organizers: Brigid L.M. Hogan, Jeffrey A. Whitsett and Christine Kim Garcia
Sponsored by Innity Pharmaceuticals
THE GUT MICROBIOME: THE EFFECTOR/
REGULATORY IMMUNE NETWORK
FEBRUARY 1015, 2013
SAGEBRUSH INN AND CONFERENCE CENTER, TAOS,
NEW MEXICO, USA (venue information on page 27)
DEADLINES:
ABSTRACT & SCHOLARSHIP OCT 9, 2012
LATE-BREAKING ABSTRACT NOV 8, 2012
DISCOUNTED REGISTRATION DEC 5, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13B3
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B3.
SUNDAY, FEBRUARY 10: ARRIVAL & REGISTRATION
MONDAY, FEBRUARY 11
Keynote Address
Dan R. Littman, New York University School of Medicine, USA
The Gut Commensal Microbiotas Effects on Systemic Autoimmunity
The Gut Microbiome
Curtis Huttenhower, Harvard School of Public Health, USA
Large-Scale Genomic Data Mining of the Human Microbiome
David A. Relman, Stanford University, USA
Assembly, Stability and Resilience of the Human Microbiome
S. Dusko Ehrlich, Institut National de la Recherche Agronomique
(INRA), France
The Human Metagenome
Short Talk(s) Chosen from Abstracts
Gut Microbiome and Immune Development
Chyi-Song Hsieh, Washington University, USA
Education of the Immune System by Commensal Microbiota
Ruth E. Ley, Cornell University, USA
Adaptive Immune Regulation of Bacterial Motility
and Community Structure
Susan V. Lynch, University of California, San Francisco, USA
Gastrointestinal Microbiome and Pediatric Asthma Development
Short Talk Chosen from Abstracts
TUESDAY, FEBRUARY 12
Gut Microbiome-APC Interactions
B. Brett Finlay, University of British Columbia, Canada
The Interface between the Immune System and Microbiota
in Infectious and Allergic Diseases
Dennis L. Kasper, Harvard Medical School, USA
Modulation of Immune Responses by Commensal Microbes
Brian L. Kelsall, NIAID, National Institutes of Health, USA
A Focus on Dendritic Cells and Macrophages as Key Regulators
of Mucosal Immunity
Grard Eberl, Institut Pasteur, France
Development and Function of Intestinal Innate Lymphoid Cells
Short Talk(s) Chosen from Abstracts
Experimental Colitis/IBD: Regulator Networks
Sarkis K. Mazmanian, California Institute of Technology, USA
Learning to Tolerate Our Microbial Self
Richard S. Blumberg, Brigham and Womens Hospital, USA
Microbial Exposure during Early Life Has Persistent Effects
on Natural Killer T Cell Function
David Artis, University of Pennsylvania School of Medicine, USA
CD4(+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity
in the Gut
Short Talk Chosen from Abstracts
WEDNESDAY, FEBRUARY 13
Gut Bacteria Modulation of Effector Networks
Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA
Regulation of Innate and Adaptive Immunity by the Commensal Microbiota
Nadine Cerf-Bensussan, Universit Paris Descartes, France
The Variable Trade-Off between Commensal Bacteria
and the Gut Immune System
Gabriel Nuez, University of Michigan, USA
In Development of Natural Th17 Cell in the Intestine through IL-1b
Fiona M. Powrie, University of Oxford NDM, UK
Interleukin-23 Drives Intestinal Inlammation through Direct Activity
on T Cells
Short Talk(s) Chosen from Abstracts
Gut Modulation of Effector/Regulatory Networks
in CNS Disease
Gurumoorthy Krishnamoorthy, Max Planck Institute
of Neurobiology, Germany
Commensal Microbiota as a Trigger of Spontaneous
Autoimmune Demyelination
Yun Kyung Lee, California Institute of Technology, USA
Proinlammatory T-Cell Responses to Gut Microbiota Promote Experimental
Autoimmune Encephalomyelitis
Lloyd H. Kasper, Dartmouth Medical School, USA
Role of Commensal Bacteria in the Regulation of Central Nervous System
Disease Demyelination
Short Talk Chosen from Abstracts
THURSDAY, FEBRUARY 14
Modulation of Gut Microbiota and Autoimmunity
Peter J. Turnbaugh, Harvard University, USA
The Effect of Diet on the Human Gut Microbiome:
A Metagenomic Analysis in Humanized Gnotobiotic Mice
Duccio Cavalieri, Universit di Firenze, Italy
Microbiota in Children of Divergent Cultures
Fergus Shanahan, National University of Ireland, Ireland
Diet, Microbes and Metabolic Health
Javier Ochoa-Repraz, EMD Serono, Inc., USA
The Gut as a Source of Small Molecule Therapeutics
Short Talk(s) Chosen from Abstracts
Gut Bacteria Modulation of Autoimmunity
Mogens Jakobsen, University of Copenhagen, Denmark
Gut Microbiota and Diabetes
Alexander Chervonsky, University of Chicago, USA
Innate Immune Signaling and the Gut Microbiota in Type 1 Diabetes
Diane J. Mathis, Harvard Medical School, USA
Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis
via T Helper 17 Cell
FRIDAY, FEBRUARY 15: DEPARTURE
This conference will also feature poster sessions, providing excellent opportunities to
network and discuss your research. Submit your abstract online by the deadlines listed
above for the chance to present during a poster or plenary session.
31
Scientic Organizers: Lloyd H. Kasper, Javier Ochoa-Repraz and Sarkis K. Mazmanian
Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc.
B CELL DEVELOPMENT
AND FUNCTION
FEBRUARY 1015, 2013
KEYSTONE RESORT, KEYSTONE, COLORADO, USA
(venue information on page 45)
Scientic Organizers: Max D. Cooper, Andrea Cerutti and Carola G. Vinuesa
Sponsored by Onyx Pharmaceuticals, Inc.
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X1.
JOINT WITH...
SUNDAY, FEBRUARY 10: ARRIVAL & REGISTRATION
Keynote Session (Joint)
Myron S. Cohen, University of North Carolina at Chapel Hill, USA
HIV Prevention: Lessons Learned and the Changing Landscape
for HIV Vaccines
Michel C. Nussenzweig, Rockefeller University, USA
The Human Antibody Response to HIV
MONDAY, FEBRUARY 11
B Cell Genesis
Ana Cumano, Institut Pasteur, France
Mechanisms for B Cell Commitment of Hematopoietic Progenitors
Thomas Graf, Center for Genomic Regulation, Spain
Factors Regulating B Cell to Myeloid Cell Conversion
Rudolf Grosschedl, Max Planck Institute of Immunobiology
and Epigenetics, Germany
Mechanisms Underlying Transcriptional Control of B Cell Differentiation
Frederick W. Alt, HHMI/Childrens Hospital Boston and Immune
Disease Institute, USA
Regulation and Dysregulation of V(DJ Gene Recombination
Early Events in B Cell Activation
Facundo D. Batista, Cancer Research UK London Research Institute, UK
Dynamic Imaging of Lymphocyte Activation From Single Molecule
to Living Tissue
Michael Reth, Max Planck Institute of Immunobiology and
Epigenetics, Germany
Role of Protein Islands for the Activation of B Cells
Susan K. Pierce, NIAID, National Institutes of Health, USA
Molecular Assembly of BCR Oligomers
Short Talk Chosen from Abstracts
TUESDAY, FEBRUARY 12
B Cell Evolution and Repertoire Selection
Max D. Cooper, Emory University, USA
Evolution of Adaptive Immunity in Vertebrates
Garnett H. Kelsoe, Duke University Medical Center, USA
Genetic Control of the First Tolerance Checkpoint in B Cells
Hedda Wardemann, Max Planck Institute for Infection Biology, Germany
V(DJ Gene Repertoire in Adult B Cells
Michael S. Neuberger, Medical Research Council, UK
Mechanisms of Somatic Hypermutation and Class Switch Recombination
via AID
Short Talk(s) Chosen from Abstracts
Mucosal Antibody Responses (Joint)
Andrea Cerutti, Mount Sinai School of Medicine, USA
Regulation and Function of Mucosal IgA and IgD in Humans
Sidonia Fagarasan, RIKEN Research Center for Allergy
and Immunology, Japan
IgA Class Switching in Intestinal Follicles
Andrew J. Macpherson, University of Bern, Switzerland
IgA Against Commensal Intestinal Microbes Induction and Function
Short Talk Chosen fro m Abstracts
WEDNESDAY, FEBRUARY 13
Germinal Center, Plasma Cell and Memory B Cell Differentiation
Carola G. Vinuesa, Australian National University, Australia
Role of T Follicular Helper Cells in the Germinal Center Reaction
Jason G. Cyster, University of California, San Francisco, USA
In vivo Traficking of Follicular B Cells
Jacques F. Banchereau, Hoffmann-La Roche Inc., USA
Regulation of Human Plasma Cell Differentiation
Tomohiro Kurosaki, WPI Immunology Frontier Research Center,
Osaka University, Japan
In vivo Traficking of Follicular B Cells
Short Talk(s) Chosen from Abstracts
Protective Antibody Responses Against HIV (Joint)
Barton F. Haynes, Duke University Medical Center, USA
Mechanisms of Protection by Broadly Reactive Neutralizing Antibodies
to HIV Envelope
Peter D. Kwong, NIAID, National Institutes of Health, USA
Structural Biology of Neutralizing Epitopes on HIV Envelope
Dennis R. Burton, The Scripps Research Institute, USA
Antibody Protection Against HIV
Georgia D. Tomaras, Duke University Medical Center, USA
Spectrum of Vaccine-Elicited Humoral Immune Responses
THURSDAY, FEBRUARY 14
MicroRNAs and B Cell Neoplasias
Louis M. Staudt, NCI, National Institutes of Health, USA
Biology and Treatment of B Cell Lymphoma
David Baltimore, California Institute of Technology, USA
MicroRNAs, Inlammation and Cancer
Riccardo Dalla-Favera, Columbia University, USA
Molecular Pathogenesis of B Cell Lymphoma
Klaus Rajewsky, Max Delbrck Center for Molecular Medicine, Germany
MicroRNAs in Normal and Neoplastic B Cells
Short Talk(s) Chosen from Abstracts
Autoimmunity and Regulatory B Cells
Betty Diamond, Feinstein Institute for Medical Research, USA
Negative Regulation of Peripheral Autoreactive B Cells
Robert Brink, Garvan Institute of Medical Research, Australia
New Mechanisms for the Activation of Autoreactive B Cells
Edgar G. Engleman, Stanford University, USA
B Cells and Insulin Resistance
Short Talk Chosen from Abstracts
FRIDAY, FEBRUARY 15: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
32
HIV VACCINES
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X2.
DEADLINES FOR BOTH CONFERENCES:
GLOBAL HEALTH TRAVEL AWARD SEP 11, 2012
ABSTRACT & SCHOLARSHIP OCT 10, 2012
LATE-BREAKING ABSTRACT NOV 12, 2012
DISCOUNTED REGISTRATION DEC 10, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13X1 or /13X2
Scientic Organizers: Georgia D. Tomaras, Quentin J. Sattentau
and Barbara L. Shacklett
Supported by the Ofce of AIDS Research, NIH; Sponsored by Gilead Sciences, Inc.
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Registering for one conference in a set of joint conferences enables
participation in sessions of the other, pending space availability.
SUNDAY, FEBRUARY 10: ARRIVAL & REGISTRATION
Keynote Session (Joint)
Myron S. Cohen, University of North Carolina at Chapel Hill, USA
HIV Prevention: Lessons Learned and the Changing Landscape
for HIV Vaccines
Michel C. Nussenzweig, Rockefeller University, USA
The Human Antibody Response to HIV
MONDAY, FEBRUARY 11
Protective Responses in Animal Models
David H. OConnor, University of Wisconsin-Madison, USA
Genetics and SIV Protection
Genoveffa Franchini, NCI, National Institutes of Health, USA
Correlates of Protection in NHP
Kevin O. Saunders, NIAID, National Institutes of Health, USA
Short Talk: The Passive Immunization and Transfer of VRC01
in Rhesus Macaques
Ruth M. Ruprecht, Dana-Farber Cancer Institute, USA
Passive Immunization Against Mucosal R5 SHIV Transmission
Sallie Permar, Duke University Medical Center, USA
Immune Protection Against Postnatal HIV/SIV Transmission
Short Talk Chosen from Abstracts
Workshop 1: Vaccine-Elicited Immune Responses
and Potential Correlates
Short Talks Chosen from Abstracts
Potentially Protective Responses in Human Clinical Trials
Merlin L. Robb, Walter Reed Army Institute of Research, USA
Key Findings from RV Studies
Glenda Gray, University of the Witwatersrand, South Africa
Key Findings from South African Trials
Barney S. Graham, NIAID, National Institutes of Health, USA
Active and Passive Immunity Against HIV
Short Talk Chosen from Abstracts
TUESDAY, FEBRUARY 12
Quality of Immune Response (Immune Geography and Memory)
Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging Immune Cell Dynamics and Function
Jacob D. Estes, NCI, National Institutes of Health, USA
Early Events following SIV Challenge
Mario Roederer, NIAID, National Institutes of Health, USA
Determination of Immune Response Quality
Speaker Chosen from Abstracts
Short Talk(s) Chosen from Abstracts
Mucosal Antibody Responses (Joint)
Andrea Cerutti, Mount Sinai School of Medicine, USA
Regulation and Function of Mucosal IgA and IgD in Humans
Sidonia Fagarasan, RIKEN Research Center for Allergy
and Immunology, Japan
IgA Class Switching in Intestinal Follicles
Andrew J. Macpherson, University of Bern, Switzerland
IgA Against Commensal Intestinal Microbes Induction and Function
Short Talk Chosen from Abstracts
WEDNESDAY, FEBRUARY 13
CD8 and CD4 T Cell Immunity
Hendrik Streeck, Massachusetts General Hospital,
Harvard Medical School, USA
Impact of CD4 T Cell Help/TFH Cells
Olivier Lambotte, INSERM U1012, France
Cellular Control of HIV-1 Infection
Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Properties of Protective CD8 T Cell Responses
Barbara L. Shacklett, University of California, Davis, USA
T Cell Immunity: Systemic and Mucosal
Short Talk(s) Chosen from Abstracts
Workshop 2: Immune Memory
Short Talks Chosen from Abstracts
Protective Antibody Responses Against HIV (Joint)
Barton F. Haynes, Duke University Medical Center, USA
Mechanisms of Protection by Broadly Reactive Neutralizing Antibodies
to HIV Envelope
Peter D. Kwong, NIAID, National Institutes of Health, USA
Structural Biology of Neutralizing Epitopes on HIV Envelope
Dennis R. Burton, The Scripps Research Institute, USA
Antibody Protection Against HIV
Georgia D. Tomaras, Duke University Medical Center, USA
Spectrum of Vaccine-Elicited Humoral Immune Responses
THURSDAY, FEBRUARY 14
New Concepts in Innate Immunity and Stimulation
Nina Bhardwaj, New York University School of Medicine, USA
Innate Stimulation
Steven Reed, Infectious Disease Research Institute, USA
Novel Adjuvants and Immune Stimulation
Karin Lor, Karolinska Institutet, Sweden
Innate Stimulation for Generating Potent HIV Immune Responses
Short Talks Chosen from Abstracts
Antibody Genomics and Immunogen Design
John R. Mascola, NIAID, National Institutes of Health, USA
Genetics of Antibody Elicitation
William Schief, The Scripps Research Institute, USA
Structure-Based HIV Vaccine Design
Susan W. Barnett, Novartis Vaccines and Diagnostics, Inc., USA
Selection of Envs and Adjuvants for Vaccine Evaluation
Quentin J. Sattentau, Sir William Dunn School of Pathology, UK
Chemical Modiications of Env for Vaccine Design
FRIDAY, FEBRUARY 15: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
33
AUTOPHAGY, INFLAMMATION
AND IMMUNITY
FEBRUARY 1722, 2013
FAIRMONT THE QUEEN ELIZABETH, MONTREAL, QUEBEC, CANADA
(venue information on page 45)
DEADLINES:
ABSTRACT & SCHOLARSHIP OCT 16, 2012
LATE-BREAKING ABSTRACT NOV 15, 2012
DISCOUNTED REGISTRATION DEC 13, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13B4
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B4.
SUNDAY, FEBRUARY 17: ARRIVAL & REGISTRATION
MONDAY, FEBRUARY 18
Keynote Address
Douglas R. Green, St. Jude Childrens Research Hospital, USA
Autophagy and the Immunological Impact of Dying Cells
Mechanisms of Autophagy
Noboru Mizushima, Tokyo Medical and Dental University, Japan
Mammalian Atg Proteins in Autophagosome Formation
Sharon A. Tooze, London Research Institute, UK
Initiation of the Autophagosomal Membrane
Mark J. Daly

, Harvard Medical School, USA


Autophagy Genes in Human Disease
Short Talk(s) Chosen from Abstracts
Selective Autophagy and Infection
Ivan Dikic, Goethe University Medical School, Germany
Autophagy Receptors and Bacterial Autophagy
Beth Levine, University of Texas Southwestern Medical Center, USA
Novel Mediators of Selective Virophagy and Mitophagy
Tamotsu Yoshimori, Osaka University, Japan
Mechanisms of Membrane Dynamics in Selective
and Non-Selective Autophagy
Short Talk Chosen from Abstracts
TUESDAY, FEBRUARY 19
Autophagy and Infection
Pascale Cossart, Institut Pasteur, France
Autophagy and Cytosolic Bacteria
Robert L. Modlin, University of California, Los Angeles, USA
Vitamin D, Autophagy and Tuberculosis
Vojo Deretic, University of New Mexico, USA
Autophagy, Host Defense and Inlammation in Tuberculosis
Fulvio Reggiori, University Medical Centre Utrecht, Netherlands
The Autophagosomal Membrane and LC3-Positive Membranes Involved
in Viral Infection
Short Talk(s) Chosen from Abstracts
Workshop
Short Talks Chosen from Abstracts
Autophagy and Immunity
Speaker to be Announced
Late-Breaking Research
Herbert (Skip) W. Virgin IV, Washington University School
of Medicine, USA
Autophagy Proteins and Macrophage-Based Immunity to Infection
Tatsuya Saitoh, Osaka University, Japan
Role of Atg14L1 in Autophagy and Immunity
Short Talk Chosen from Abstracts
WEDNESDAY, FEBRUARY 20
Autophagy and the Inlammasome
Gkhan S. Hotamisligil, Harvard University, USA
Metabolic Inlammasome
Jenny P. Ting, University of North Carolina at Chapel Hill, USA
Fatty Acid Regulation of the Inlammasome
Augustine Choi, Harvard Medical School, USA
Autophagy, Mitochondria and the Inlammasome
Nobuhiko Kayagaki, Genentech, Inc., USA
The Non-Canonical Inlammasome and Caspase 11
Short Talk(s) Chosen from Abstracts
Autophagy and Inlammatory Signaling
Masaaki Komatsu, Tokyo Metropolitan Institute of Medical
Science, Japan
Autophagy and the Nrf2-Keap 1 Pathway in Stress Response
Jorge Moscat, Sanford-Burnham Medical Research Institute, USA
p62: A Multifunctional Signaling Molecule in Cancer Metabolism
Sergio Grinstein, Hospital for Sick Children, Canada
PI3 Kinases and Reactive Oxygen Species in Phagosome Maturation
Short Talk Chosen from Abstracts
THURSDAY, FEBRUARY 21
Autophagy in Metabolic and Inlammatory Disease
Mark J. Czaja, Albert Einstein College of Medicine, USA
Autophagy and Lipid Metabolism
Ramnik Xavier, Massachusetts General/Broad Institute, USA
Autophagy Genes and Inlammatory Bowel Disease
Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Intestinal Epithelial Cell Autophagy and the Microbiota
Thaddeus S. Stappenbeck, Washington University School
of Medicine, USA
Autophagy Proteins and Regulation of Intestinal Inlammation
Short Talk(s) Chosen from Abstracts
Autophagy in Cell Death and Cancer Immunity
Eileen P. White, Rutgers University, USA
Autophagy in Tumor Cell Survival
Guido Kroemer, Institut Gustave Roussy, France
Autophagy-Dependent Anti-Tumor Immunity
Speaker to be Announced
Late-Breaking Research
Short Talk Chosen from Abstracts
FRIDAY, FEBRUARY 22: DEPARTURE

Invited, not yet accepted


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
Scientic Organizers: Herbert (Skip) W. Virgin IV, Beth Levine and Gkhan S. Hotamisligil
Sponsored by Abbott Laboratories and Vertex Pharmaceuticals Incorporated
34
NUTRITION, EPIGENETICS
AND HUMAN DISEASE
FEBRUARY 1924, 2013
HILTON SANTA FE HISTORIC PLAZA HOTEL, SANTA FE,
NEW MEXICO, USA (venue information on page 45)
DEADLINES:
ABSTRACT & SCHOLARSHIP OCT 17, 2012
LATE-BREAKING ABSTRACT NOV 19, 2012
DISCOUNTED REGISTRATION DEC 17, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13B5
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B5.
Scientic Organizers: Robert A. Waterland, David S. Rosenblatt and Patrick J. Stover
TUESDAY, FEBRUARY 19: ARRIVAL & REGISTRATION
WEDNESDAY, FEBRUARY 20
Keynote Address
Ezra S. Susser, Columbia University, USA
The Developmental Origins of Neurodevelopmental Disorders
Nutrition and Epigenetics in Development and Disease
of the CNS
Arthur L. Beaudet, Baylor College of Medicine, USA
The Role of Epigenetics and Carnitine Metabolism in Autism
Peng Jin, Emory University School of Medicine, USA
Epigenetic Mechanisms in Neural Development and Disease
Ryszard Maleszka, Australian National University, Australia
Nutritional Regulation of Differential Methylation in Development
and Behavior of Honeybees
Short Talk(s) Chosen from Abstracts
Nutrient Regulation of the Epigenetic Machinery
Roderick Dashwood, Oregon State University, USA
Mechanisms Underlying Non-Nutritive Bioactive Food Components
and Histone Modiications
Paolo Sassone-Corsi, University of California, Irvine, USA
SIRT1: The Link between Energy Balance, Chromatin Remodeling
and Circadian Physiology
Speaker to be Announced
Nutrient Regulation of DNA Methylase and Demethylase Activity
THURSDAY, FEBRUARY 21
Nutrition and Epigenetics in Obesity
Richard B. Simerly, Childrens Hospital Los Angeles, University
of Southern California, USA
Nutritional-Endocrine Interactions in Postnatal Hypothalamic
Development
Joseph H. Nadeau, Institute for Systems Biology, USA
Ancestral Paternal Genotype Affects Body Weight and Food Intake
Transgenerationally
Short Talk(s) Chosen from Abstracts
Robert A. Waterland, Baylor College of Medicine, USA
Nutritional Inluences on Hypothalamic Developmental Epigenetics
Speaker to be Announced
Epigenetic Factors in Adipose Tissue Endocrine Dysregulation in Obesity
Nutrient, Methyl Metabolism and Epigenetic Interactions
David S. Rosenblatt, McGill University, Canada
Discovering New Genes in the One Carbon Pathway
Using Exome Sequencing
Patrick J. Stover, Cornell University, USA
Regulation of the Folate Metabolic Network during Mouse Development,
and its Impact on Genome Methylation and Stability
Rima Rozen, McGill University, Canada
Impact of Genetic and Nutritional Variation in Folate Metabolism on
Cellular Methylation Capacity
FRIDAY, FEBRUARY 22
Nutrition and Developmental Epigenetics
in the Endocrine Pancreas
Miguel Constancia, University of Cambridge, UK
Maternal Dietary Effects on Epigenetic Regulation of Enhancers
in Pancreatic Islets
Frans C. Schuit, Katholieke Universiteit Leuven, Belgium
-Cell Speciic Epigenetic Repression of Disallowed Genes:
Implications for Development and Disease
Short Talk(s) Chosen from Abstracts
Speaker to be Announced
Epigenetic Mechanisms in Lipotoxicity in the Endocrine Pancreas
Jorge Ferrer, Institut dInvestigacions Biomediques Auguts Pi i Sunyer
(IDIBAPS), Spain
Regulation of the Epigenome in Human Pancreatic Islet Cells
Nutrients and Allelic Targeting of Epigenetic Signatures
J. Kim Kemper, University of Illinois at Urbana-Champaign, USA
Nuclear Receptor and Small Heterodimer Partner Recruitment of
Chromatin Remodeling in the Regulation of Lipid and Glucose Metabolism
Chen-Yu Zhang, Nanjing University, China
Regulation of Human Gene Expression by Dietary miRNAs
Speaker to be Announced
siRNA Targeting of Genes for Site-Speciic Methylation
SATURDAY, FEBRUARY 23
Nutritional Modulation of Stem Cell Programming
Sir John B. Gurdon, University of Cambridge, UK
Epigenetics and Nuclear Reprogramming by Eggs and Oocytes
Yi Eve Sun, University of California, Los Angeles, USA
Development Plasticity in Differentiation of Neural Stem Cells
Implications for Development Programming
Short Talk(s) Chosen from Abstracts
Lanlan Shen, Baylor College of Medicine, USA
Nutritional Inluences on Stem Cell Developmental Epigenetics
in the Colonic Crypt
Speaker to be Announced
Epigenomic Analysis of Hematopoietic Stem Cells
Undergoing Differentiation
Present and Future: Pressing Issues
in Environmental Epigenetics
Jean-Pierre Issa, Temple University School of Medicine, USA
Nutrition, Epigenetics and Cancer
Andrew M. Prentice, London School of Hygiene and Tropical Medicine, UK
Long-Term Consequences of Maternal and Child Nutrition
in Developing Countries
Scott F. Gilbert, Swarthmore College, USA
The Global Environment and Ecological Developmental Biology
SUNDAY, FEBRUARY 24: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
35
MYELOID CELLS:
REGULATION AND INFLAMMATION
FEBRUARY 1924, 2013
KEYSTONE RESORT, KEYSTONE, COLORADO, USA
(venue information on page 45)
DEADLINES:
ABSTRACT & SCHOLARSHIP OCT 18, 2012
LATE-BREAKING ABSTRACT NOV 19, 2012
DISCOUNTED REGISTRATION DEC 17, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13B6
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B6.
Scientic Organizers: Vincenzo Cerundolo, Gwendalyn J. Randolph and David M. Mosser
TUESDAY, FEBRUARY 19: ARRIVAL & REGISTRATION
WEDNESDAY, FEBRUARY 20
Keynote Address
Siamon Gordon, University of Oxford, UK
Pro- and Anti-Inlammatory Role of Myeloid Cells
Myeloid Lineage Differentiation
Irving L. Weissman, Stanford University, USA
Differentiation of GMP into Granulocytes and Monocytes
Paul S. Frenette, Albert Einstein College of Medicine, USA
Mobilization from the Bone Marrow of Myeloid Cells
Paresh Vyas, University of Oxford, UK
Lineage Differentiation of AML
Michael H. Sieweke, Centre dImmunologic Marseille-Luming, France
Transcriptional Control of Myeloid Cell Fate and Self Renewal
Short Talk Chosen from Abstracts
Plasticity of Myeloid Cells
David M. Mosser, University of Maryland, USA
Macrophage Plasticity
Vincenzo Cerundolo, University of Oxford, UK
Plasticity of PMN in Cancer
Judith E. Allen, University of Edinburgh, UK
Local Macrophage Proliferation
THURSDAY, FEBRUARY 21
Myeloid Cells during Inlammation
Ajay Chawla, University of California, San Francisco, USA
Monocyte Subsets and Metabolic Disease
Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA
Pathogens and Mucosal Immunity
Christopher K. Glass, University of California, San Diego, USA
A Genome-Wide View of Macrophage Activation
Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany
NETs From Infection to Autoimmunity
Short Talk(s) Chosen from Abstracts
Workshop 1: Inlammation and Chemokine Receptors
Short Talks Chosen from Abstracts
Myeloid Cell Migration and Traficking
Gwendalyn J. Randolph, Washington University, USA
Monocyte Migration
Paul Kubes, University of Calgary, Faculty of Medicine, Canada
Traficking of Neutrophils
Frederic Geissmann, Kings College London, UK
Inlammatory Monocytes
FRIDAY, FEBRUARY 22
Signaling Events
Luke A. J. ONeill, Trinity College Dublin, Ireland
MicroRNAs in TLR Signaling Events
Caetano Reis e Sousa, Cancer Research UK London Research
Institute, UK
Innate Immune Recognition of Cell Death
Alan Aderem, Seattle BioMed, USA
Innate Mechanisms for Intracellular Bacteric
Jenny P. Ting, University of North Carolina at Chapel Hill, USA
Inlammasomes
Short Talk(s) Chosen from Abstracts
Workshop 2: Myeloid Regulatory Cells
Short Talks Chosen from Abstracts
Myeloid Cells during Pathogen Infections
Denise M. Monack, Stanford University, USA
Inlammasome Activation and Bacterial Infections
Bali Pulendran, Emory University, USA
Immunlogical Signatures
John Schoggins, Rockefeller University, USA
Interferon Antiviral Responses
SATURDAY, FEBRUARY 23
Myeloid Cells Modulating Adaptive Immune Responses
Miriam Merad, Mount Sinai Medical Center, USA
Cutaneous DC and T Cells
Ronald N. Germain, NIAID, National Institutes of Health, USA
Myeloid Cell Localization, Interactions and Traficking in Tissues
Kenneth M. Murphy, Washington University School of Medicine, USA
DC and Adaptive Immune Response
Matteo Iannacone San Raffaele Scientiic Institute Italy
Lymph Node Macrophages and Antiviral Immune Responses
Short Talk(s) Chosen from Abstracts
Myeloid Cells in Pathologies and in the Clinic
Virginia Pascual, Baylor Institute for Immunology Research, USA
Neutrophils and SLE
Jeffrey W. Pollard, Albert Einstein College of Medicine, USA
Macrophages and Tumor Progression
Alan Sher, NIAID, National Institutes of Health, USA
Talk Title to be Determined
SUNDAY, FEBRUARY 24: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
36
STEM CELL REGULATION
IN HOMEOSTASIS AND DISEASE
FEBRUARY 24MARCH 1, 2013
FAIRMONT BANFF SPRINGS, BANFF, ALBERTA, CANADA
(venue information on page 45)
DEADLINES:
ABSTRACT & SCHOLARSHIP OCT 24, 2012
LATE-BREAKING ABSTRACT NOV 27, 2012
DISCOUNTED REGISTRATION DEC 18, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13B7
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B7.
Scientic Organizers: Sean J. Morrison, Iannis Aifantis and Yukiko M. Yamashita
SUNDAY, FEBRUARY 24: ARRIVAL & REGISTRATION
MONDAY, FEBRUARY 25
Keynote Address
George Q. Daley, Childrens Hospital Boston, USA
Disease Modeling in iPS Cells
Pluripotency and Disease Modeling
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
DNA Methylation, TET Proteins and Pluripotency
Konrad Hochedlinger, Massachusetts General Hospital, USA
Sox2(+ Adult Stem and Progenitor Cells Are Important for Tissue
Regeneration and Survival of Mice
Kathrin Plath, University of California, Los Angeles, USA
Insights into Reprogramming Mechanisms
Deepak Srivastava, Gladstone Institute of Cardiovascular Disease, USA
Talk Title to be Determined
Short Talk(s) Chosen from Abstracts
Stem Cells and Regeneration
Trista E. North, Beth Israel Deaconess Medical Center, USA
Metabolic Regulation of Hematopoietic Stem Cell Formation
Alejandro Snchez Alvarado, HHMI/Stowers Institute
for Medical Research, USA
Planaria
David T. Scadden, MGH/Harvard University, USA
The Pysiological Function of Mesenchymal Stem Cells
Short Talk Chosen from Abstracts
TUESDAY, FEBRUARY 26
Niche Regulation of Stem Cell Function
Allan C. Spradling, HHMI/Carnegie Institute, USA
Stem Cells and Tissue Homeostasis
Valerie Horsley, Yale University, USA
Skin Stem Cell Niche
Fiona Doetsch, Columbia University, USA
Stem Cells and their Niche in the Adult Mammalian Brain
Sean J. Morrison, HHMI/University of Texas Southwestern
Medical Center, USA
Hematopoietic Stem Cell Niche
Short Talk(s) Chosen from Abstracts
Emerging Regulatory Mechanisms
Iannis Aifantis, HHMI/New York University School of Medicine, USA
E3 Ligases in HSC Differentiation
K. J. Patel, MRC Laboratory of Molecular Biology, UK
Mechanisms to Prevent DNA Damage by Metabolites in Stem Cells
Yukiko M. Yamashita, University of Michigan, Ann Arbor, USA
Cellular Polarity, Germline Stem Cell Maintenance and Aging
Short Talk Chosen from Abstracts
WEDNESDAY, FEBRUARY 27
RNA Regulation and Stem Cells
Haifan Lin, Yale University, USA
RNA Stability in Fly Stem Cells
Robert H. Blelloch, University of California, San Francisco, USA
MicroRNA Regulation of Pluripotency
Richard Iain Gregory, Harvard Medical School, Childrens Hospital, USA
Lin28, Let-7 and Stem Cells
Judith E. Kimble, University of Wisconsin-Madison, USA
Notch Signaling and an RNA Regulatory Network Control C. elegans
Germline Stem Cells
Short Talk(s) Chosen from Abstracts
Stem Cells and Cancer
Richard J. Gilbertson, St. Jude Childrens Research Hospital, USA
Lineage Tracing in Normal Stem Cells and Cancer
Austin Gurney, OncoMed Pharmaceuticals, USA
Targeting Stem Cell Pathways in Cancer
Luis F. Parada, University of Texas Southwestern Medical Center, USA
Lineage Tracing in Brain Tumors
Short Talk Chosen from Abstracts
THURSDAY, FEBRUARY 28
The Aging of Mitotic Cells
Andrew G. Dillin, The Salk Institute for Biological Studies, USA
Protein Quality Control in Stem Cells and Aging
Anne Brunet, Stanford University, USA
The Regulation of Stem Cell Aging
Manuel Serrano, Spanish National Cancer Center (CNIO), Spain
Tumor Suppressors and Lifespan
Norman E. Sharpless, University of North Carolina School
of Medicine, USA
Regeneration and Aging
Short Talk(s) Chosen from Abstracts
Self-Renewal Pathways and Disease
Alexandra Joyner, Memorial Sloan-Kettering Institute, USA
Sonic Hedgehog and the Regulation of Neural Stem Cells
Frederic J. de Sauvage, Genentech, Inc., USA
Targeting Sonic Hedgehog Signaling in Cancer
Fernando D. Camargo, Childrens Hospital Boston, USA
Hippo Signaling
FRIDAY, MARCH 1: DEPARTURE

This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
37
PI 3-KINASE AND INTERPLAY
WITH OTHER SIGNALING PATHWAYS
FEBRUARY 24MARCH 1, 2013
KEYSTONE RESORT, KEYSTONE, COLORADO, USA
(venue information on page 45)
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X3.
JOINT WITH...
SUNDAY, FEBRUARY 24: ARRIVAL & REGISTRATION
Keynote Session
Kevan M. Shokat*, University of California, San Francisco, USA
Jose Baselga*, Massachusetts General Hospital, USA
Christian Rommel*, USA
Peter K. Vogt, The Scripps Research Institute, USA
Oncogenes in the PI3K Pathway
Roger L. Williams, Medical Research Council, UK
The PI3K Pathway by Protein Structures
MONDAY, FEBRUARY 25
PI3K/Akt/mTOR Pathway in Cancer (Clinical Part 1)
Jose Baselga*, Massachusetts General Hospital, USA
Breast Cancer
Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA
Overcoming Resistance to Targeted Therapies
Vito J. Palombella Ininity Phaimaceuticals Inc 0SA
Development of Potent PI3K-/ Inhibitors
Yardena Samuels, NHGRI, National Institutes of Health, USA
Human Cancer Genetics
Short Talk(s) Chosen from Abstracts
PI3K/Akt/mTOR Pathway (Clinical Part 2)
William R. Sellers*, Novartis Institutes for BioMedical Research, USA
PI3K
Kui Lin, Genentech, Inc, USA
Akt
Christian Rommel, USA
TORC1/2
TUESDAY, FEBRUARY 26
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
Jeffrey Adam Engelman*, Massachusetts General Hospital, USA
Resistance Mechanisms
Sebastian Nijman, CeMM, Austria
Resistance Mechanisms
Lori Friedman*, Genentech, Inc., USA
Combination Therapies
Short Talk(s) Chosen from Abstracts
PI3K/mTOR Pathway Signaling Networks (Preclinical)
Kevan M. Shokat*, University of California, San Francisco, USA
Polypharmacological Targeting of The P13K/mTOR
and Raf/Mek Pathways of Cancer
John Blenis, Harvard University Medical School, USA
mTOR Complex 1, Metabolism and Cell Growth Control
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Regulation of Growth by the mTOR Pathway
Short Talk Chosen from Abstracts
WEDNESDAY, FEBRUARY 27
PI3K-Related Pathways (Preclinical)
Lewis C. Cantley*, Harvard Medical School, USA
PI3K and Cancer Metabolism
Judith A. Varner, University of California, San Diego, USA
PI3K Control of Innate Immunity in Cancer
Karen M. Cichowski, Brigham and Women's Hospital, Harvard
Medical School, USA
Developing Combination Therapies with PI 3-K/mTOR Pathway Inhibitors
Hong Wu, University of California, Los Angeles, USA
Hormone Cross-Talk Signaling
Short Talk(s) Chosen from Abstracts
PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical)
Christian Rommel*, USA
Julian H. Downward, Cancer Research UK, UK
Links between RAS Family GTPases and PI3K Signaling
Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA
Interplay Signaling
Pier Paolo Pandoli, Beth Israel Deaconess Medical Center/Harvard
Medical School, USA
Talk Title to be Determined
Short Talk Chosen from Abstracts
THURSDAY, FEBRUARY 28
PI3K-Related Pathways (Preclinical)
Bart Vanhaesebroeck*, Barts and The London School of Medicine, UK
PI3K and Mitosis
Davide Ruggero, University of California, San Francisco, USA
Ribosome Signaling
Jonathan Hart, The Scripps Research Institute, USA
PI3K/mTOR/STAT Signaling
William A. Weiss, University of California, San Francisco, USA
Autophagy
Short Talk(s) Chosen from Abstracts
PI3K-Related Pathways (Preclinical)
David A. Fruman, University of California, Irvine, USA
Mechanism of mTOR Inhibitor Action in Lymphocytes
Brendan D. Manning, Harvard School of Public Health, USA
The TSC-mTOR Network in Cancer and Metabolism
Ramon Parsons, Columbia University, USA
PTEN Signaling
FRIDAY, MARCH 1: DEPARTURE
*Session Chair
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
38
Scientic Organizers: Christian Rommel, Kevan M. Shokat and Jose Baselga
Sponsored by Bayer USA Foundation, Gilead Sciences, Inc. and Innity Pharmaceuticals
TUMOR METABOLISM
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X4.
DEADLINES FOR BOTH CONFERENCES:
ABSTRACT & SCHOLARSHIP OCT 25, 2012
LATE-BREAKING ABSTRACT NOV 28, 2012
DISCOUNTED REGISTRATION DEC 19, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13X3 or /13X4
Scientic Organizers: Matthew G. Vander Heiden and Karen H. Vousden
Sponsored by Bayer USA Foundation
Registering for one conference in a set of joint conferences enables
participation in sessions of the other, pending space availability.
SUNDAY, FEBRUARY 24: ARRIVAL & REGISTRATION
MONDAY, FEBRUARY 25
Keynote Address
Craig B. Thompson, Memorial Sloan-Kettering Cancer Center, USA
Metabolic Control of Tumor Cell Growth and Survival
Metabolic Regulation
Almut Schulze, Cancer Research UK, UK
The Role of Glucose and Lipid Metabolism in Growth and Survival
of Cancer Cells
Sally A. Kornbluth, Duke University Medical Center, USA
Metabolic Control of Cell Physiology
Linda Z. Penn, Ontario Cancer Institute, Canada
Understanding and Exploiting the Oncogenic Capacity
of the Mevalonate Pathway
Short Talk(s) Chosen from Abstracts
Nutrient Sensing
Eileen P. White, Rutgers University, USA
Autophagy as a Response to Nutrient Deprivation
Reuben J. Shaw, The Salk Institute, USA
Signaling Events to Cope with Energy Stress
David M. Sabatini, Whitehead Institute for Biomedical
Research, USA
Amino Acid Sensing Mechanisms
TUESDAY, FEBRUARY 26
Metabolic Adaptation
Chi Van Dang, University of Pennsylvania, USA
Glutamine and Cellular Energetics
Karen H. Vousden, Beatson Institute for Cancer Research, UK
Metabolic Adaptation Controlled by p53
Eyal Gottlieb, Beatson Institute for Cancer Research, UK
Revealing New Metabolic Networks in Cancer
Matthew G. Vander Heiden, Massachusetts Institute
of Technology, USA
Metabolic Pathways Important for Cell Growth
Short Talk(s) Chosen from Abstracts
Understanding the Metabolic Network
Eytan Ruppin, Tel Aviv University, Israel
Harnessing Genome-Scale Metabolic Modeling
to Study Cancer Metabolism
Joshua D. Rabinowitz, Princeton University, USA
Measuring Metabolic Flux
Benjamin F. Cravatt III, The Scripps Research Institute, USA
Functional Enzyme Characterization
WEDNESDAY, FEBRUARY 27
Inluence of the Microenvironment on Metabolism
Jacques Pouyssgur, University of Nice, France
Role of Oxygen in Controlling Cancer Metabolism
M. Celeste Simon, University of Pennsylvania, USA
Tumor Cell Adaptation to the Microenvironment
Amato J. Giaccia, Stanford University, USA
Oxygen Sensing and Metabolic Control
Salvador Moncada, University College London, UK
Sensing the Microenvironment to Inluence Metabolism
Short Talk(s) Chosen from Abstracts
Insights from in vivo Experiments
Tak W. Mak, Campbell Family Institute for Breast Cancer Research
at Princess Margaret Hospital, UHN, Canada
Tumor Metabolism Insight from Mouse Models
Yanping Zhang, University of North Carolina at Chapel Hill, USA
Ribosomal Protein-Mdm2-p53 Signaling and Energy Metabolism
Ralph J. DeBerardinis, University of Texas Southwestern
Medical Center, USA
Measuring Metabolism and Metabolites in vivo
Speaker to be Announced
Imaging Glutamine Metabolism in Patient Tumors Using PET
THURSDAY, FEBRUARY 28
Targeting Metabolism
Bing Lim, Genome Institute of Singapore, Singapore
Targeting Glycine Metabolism for Cancer Therapy
Speaker to be Announced
Targeting Fatty Acid Metabolism
Susan Critchlow, AstraZeneca, UK
Targeting Lactate Metabolism
Joan S. Brugge, Harvard Medical School, USA
Use of 3D Culture Models to Understand the Impact of Targeted
Therapy on Metabolism
Short Talk(s) Chosen from Abstracts
Inluence of Metabolism on Epigenetic Regulation
Yue Xiong, University of North Carolina at Chapel Hill, USA
Inluence of Metabolism on Signal Transduction
Kathryn E. Wellen, University of Pennsylvania, USA
Use of Metabolic Pathways to Sense Cell State
Katherine Yen, Agios Pharmaceuticals, USA
Inluence of IDH Mutations on the Epigenetic State of Cells
FRIDAY, MARCH 1: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
39
STRUCTURAL ANALYSIS
OF SUPRAMOLECULAR ASSEMBLIES
BY HYBRID METHODS
MARCH 37, 2013
GRANLIBAKKEN RESORT, TAHOE CITY, CALIFORNIA, USA
(venue information on page 27)
DEADLINES:
ABSTRACT & SCHOLARSHIP NOV 5, 2012
LATE-BREAKING ABSTRACT DEC 3, 2012
DISCOUNTED REGISTRATION DEC 19, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13C1
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C1.
Scientic Organizers: Andrej Sali, Brian T. Chait and David Baker
SUNDAY, MARCH 3: ARRIVAL & REGISTRATION
MONDAY, MARCH 4
Keynote Address
Robert T. Tjian, HHMI/University of California, Berkeley, USA
Integrative Approaches to Studying the Cell
Computation for Hybrid Approaches
Andrej Sali, University of California, San Francisco, USA
Integrative Structure Determination of Macromolecular Assemblies
David Baker, University of Washington, USA
Hybrid Methods for Atomic Structure Determination
Gregory A. Voth, University of Chicago, USA
Multi-Scale Models of Biological Macromolecules
Zaida (Zan) Luthey-Schulten, University of Illinois at Urbana-
Champaign, USA
Whole Cell Simulations
Short Talk Chosen from Abstracts
Hybrid Approaches to Studying Dynamic Systems
James R. Williamson, The Scripps Research Institute, USA
Hybrid Studies of Ribosome Assembly in Cells
Joseph D. Puglisi, Stanford University, USA
Hybrid Studies of the Ribosome Function
Klaus Schulten, University of Illinois at Urbana-Champaign, USA
Simulation of Dynamics of Large Macromolecular Systems
Short Talk Chosen from Abstracts
TUESDAY, MARCH 5
Hybrid Approaches to Studying
Macromolecular Structures
Ian A. Wilson, The Scripps Research Institute, USA
Hybrid Approaches to Antibody Virus Systems
Holger Stark, Max Planck Institute for Biophysical
Chemistry, Germany
Hybrid Structural Studies of the Splicing Machinery
Wolfgang P. Baumeister, Max Planck Institute
of Biochemistry, Germany
Hybrid Studies of the Structure and Function of the 26S Proteasome
David A. Agard, University of California, San Francisco, USA
Hybrid Approaches to Tubulin Assembly
Short Talk(s) Chosen from Abstracts
Workshop and Panel 1: Key Bottlenecks in Hybrid
Method Development
Short Talks Chosen from Abstracts
Hybrid Approaches to Studying Cellular Organization
Benjamin Geiger, Weizmann Institute of Science, Israel
Talk Title to be Determined
Frank Alber, University of Southern California, USA
Genome Organization by Integrative Structure Determination
Graham Johnson, University of California, San Francisco, USA
Modeling and Animating the Cellular Mesoscale
Short Talk Chosen from Abstracts
WEDNESDAY, MARCH 6
Single Molecule Methods
Stefan W. Hell, Max Planck Institute for Biophysical Chemistry, Germany
Nanoscopy with Focused Light
Jennifer A. Lippincott-Schwartz, NICHD, National Institutes
of Health, USA
Use of Photoactivated Localization Microscopy (PALM for High-Density
Mapping of Single Molecules and their Trajectories at the Nanoscale
Scott C. Blanchard, Weill Cornell Medical College, USA
Single-Molecule Imaging of Biological Systems
X. Sunney Xie, Harvard University, USA
Single Molecule Enzymology
Short Talk(s) Chosen from Abstracts
Workshop and Panel 2: Latest Advances in Hybrid Methods
Short Talks Chosen from Abstracts
Latest Advances in Hybrid Methods
Brian T. Chait, Rockefeller University, USA
Mass Spectrometry and Proteomics for Hybrid Structure Determination
Carolyn A. Larabell, University of California, San Francisco, USA
X-Ray Tomography of Cells
Michael Nilges, Institut Pasteur, France
Inferential Structure Determination
Short Talk Chosen from Abstracts
THURSDAY, MARCH 7: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract online
by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
40
UNDERSTANDING DENDRITIC CELL BIOLOGY
TO ADVANCE DISEASE THERAPIES
MARCH 38, 2013
KEYSTONE RESORT, KEYSTONE, COLORADO, USA
(venue information on page 45)
DEADLINES:
ABSTRACT & SCHOLARSHIP NOV 6, 2012
LATE-BREAKING ABSTRACT DEC 3, 2012
DISCOUNTED REGISTRATION DEC 20, 2012
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13C2
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C2.
Scientic Organizers: Miriam Merad and Bart N. Lambrecht
SUNDAY, MARCH 3: ARRIVAL & REGISTRATION
MONDAY, MARCH 4
Keynote Address
Michel C. Nussenzweig, Rockefeller University, USA
Ralph Steinman and the Dendritic Cell Discovery
Development of Tissue-Resident and Inlammatory DC
Miriam Merad*, Mount Sinai Medical Center, USA
The DC Lineage
Boris Reizis, Columbia University, USA
Regulation of DC and PDC Development
Bernard Malissen, Centre dImmunologie de Marseille-Luminy, France
Transcriptional Proiling of DC Subsets
Kenneth M. Murphy*, Washington University School of Medicine, USA
Transcriptional Control of DC Development
Short Talk Chosen from Abstracts
Workshop 1: DC and Macrophage Genomics
Bernard Malissen*, Centre dImmunologie de Marseille-Luminy, France
Short Talks Chosen from Abstracts
Transcriptional Control of DC Development and Function
Hideki Ueno, Baylor Institute for Immunology Research, USA
Functional Specialization of Human DC Subsets
Nir Hacohen, Massachusetts General Hospital, USA
Regulatory Networks Underlying Dendritic Cell Activation
Bali Pulendran*, Emory University, USA
Systems Analysis of Immune Response in Humans
Short Talk Chosen from Abstracts
TUESDAY, MARCH 5
Cell Biology and Antigen Processing
Bart N. Lambrecht*, Ghent University, Belgium
ER Stress and DC Function
Averil I. Ma, University of California, San Francisco, USA
Ubiquitination and DC Function
Sebastian Amigorena*, Institut Curie, France
Control of Antigen Presentatation by Human DC
Akiko Iwasaki

, Yale University School of Medicine, USA


Autophagy and Antigen Presentation
Short Talk(s) to be Announced
Workshop 2: Regulation of DC Function
Peter T. Lee*, Cell Press, USA
Caetano Reis e Sousa*, Cancer Research UK London Research
Institute, UK
Short Talks Chosen from Abstracts
Molecular and Functional Aspects of DC Migration
Speaker to be Announced
Reinhold Frster, Hannover Medical School, Germany
Intranodal Behavior of DC
Michael Sixt, Institute of Science and Technology Austria, Austria
Cytoskeletal Dynamics of Dendritic Cells
Short Talk Chosen from Abstracts
WEDNESDAY, MARCH 6
DC Sensing of the Environment
Eicke Latz, Institute of Innate Immunity, Bonn University, Germany
Inlammasome Activation in Macrophages and DC
Monsef Benkirane, Institut de Genetique Humaine, France
DC HIV Interaction
Caetano Reis e Sousa*, Cancer Research UK London Research
Institute, UK
Cell Death Receptors for Cross-Presentation
Laurence Zitvogel*, Institut Gustave Roussy, France
DC Sensing of Cell Death
Short Talk(s) Chosen from Abstracts
Role of PDC in Immunity and Disease
Yong-Jun Liu*, Baylor Research Institute, USA
DNA Sensors in PDC
Marco Colonna, Washington University School of Medicine, USA
PDC in Host Defense
Toshiaki Ohteki, Tokyo Medical and Dental University, Japan
PDC Control of Mucosal Immunity
Short Talk Chosen from Abstracts
THURSDAY, MARCH 7
Role of DC in Pathogenesis
Speaker to be Announced
William R. Heath*, University of Melbourne, Australia
DC Control of Viral Immunity
Steffen Jung*, Weizmann Institute of Science, Israel
Control of Mucosal Immunity by DCs and Macrophages
Hamida Hammad, Ghent University, Belgium
Role of Dendritic Cells in the Pathogenesis of Asthma
Short Talk(s) Chosen from Abstracts
Workshop 3: Role of DC in Pathogenesis
Zoltan Fehervari*, Nature Publishing Group, UK
Short Talks Chosen from Abstracts
Harnessing DC Biology to Advance Disease Therapies
Bana Jabri, University of Chicago, USA
DC in Celiac Disease
Franck J. Barrat*, Dynavax Technologies, USA
DC Control of Autoimmunity
A. Karolina Palucka, Baylor Institute for Immunology Research, USA
DC Vaccine and Target Against Cancer
Concluding Remarks
Ira Mellman, Genentech, Inc., USA
Translating DC Biology into Medicine
FRIDAY, MARCH 8: DEPARTURE
*Session Chair

Invited, not yet accepted


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or a workshop.
41
DNA REPLICATION
AND RECOMBINATION
MARCH 38, 2013
FAIRMONT BANFF SPRINGS, BANFF, ALBERTA, CANADA
(venue information on page 45)
Scientic Organizers: James M. Berger, Wolf-Dietrich Heyer and Julia Promisel Cooper
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X5.
JOINT WITH...
SUNDAY, MARCH 3: ARRIVAL & REGISTRATION
Keynote Session (Joint)
Frederick W. Alt, HHMI/Childrens Hospital Boston and Immune Disease
Institute, USA
Mechanisms of Normal and Aberrant Recombination and Repair Processes
in Lymphocytes
Kenneth J. Marians, Memorial Sloan-Kettering Cancer Center, USA
Mechanisms of Replication Restart
MONDAY, MARCH 4
Mechanisms and Control of DNA Repair/Mechanisms
of Homologous Recombination (Joint)
Stephen C. Kowalczykowski, University of California, Davis, USA
Single-Molecule Analysis of Recombination
Maria Jasin, Memorial Sloan-Kettering Cancer Center, USA
Control of DNA Repair by BRCA1 and BRCA2
Wolf-Dietrich Heyer, University of California, Davis, USA
Mechanisms of Regulating Recombination
Roland Kanaar, Erasmus University, Netherlands
Mechanism and Control of Homologous Recombination
Short Talk(s) Chosen from Abstracts
Workshop 1: Regulation of DNA Superstructure
Short Talks Chosen from Abstracts
Postreplication Repair/Restart
Johannes C. Walter, Harvard Medical School, USA
The Mechanism of Replication-Coupled DNA Interstrand Cross-Link Repair
James E. Haber, Brandeis University, USA
Repair of Broken Yeast Chromosomes by Recombination
Wei Yang, NIDDK, National Institutes of Health, USA
Repair Polymerase Mechanisms
Short Talk Chosen from Abstracts
TUESDAY, MARCH 5
Replication Initiation Strategies across Species
Stephen P. Bell*, Massachusetts Institute of Technology, USA
Activation of the Eukaryotic Replicative DNA Helicase
Terry L. Orr-Weaver, Massachusetts Institute of Technology, USA
Changes in Gene Copy Number as a Developmental Strategy
and DNA Replication Model
Leemor Joshua-Tor, Cold Spring Harbor Laboratory, USA
Viral Initiation Mechanisns
James M. Berger, University of California, Berkeley, USA
Bacterial Initiation Mechanisms
Short Talk(s) Chosen from Abstracts
Workshop 2: DNA Repair Processes
Short Talks Chosen from Abstracts
Workshop 3: DNA Replication Processes
Short Talks Chosen from Abstracts
Replication, Chromatin and Genome Instability (Joint)
Genevive Almouzni Centie National ue la Recheiche Scientiique Fiance
Recombinational Repair and Heterochromatin
Ian D. Hickson, University of Copenhagen, Denmark
Processing of Late Replication Intermediates
Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research,
Switzerland
Chromatin, DNA Damage and DNA Replication
Short Talk Chosen from Abstracts
WEDNESDAY, MARCH 6
Genome Structure and Maintenance
Lorraine S. Symington*, Columbia University, USA
Control of Crossover Formation
Simon J. Boulton*, London Research Institute, Clare Hall Laboratories, UK
Genome Stability and the Regulation of Recombination
Stephen C. West, Cancer Research UK, UK
Making and Breaking Recombination Intermediates
Richard D. Kolodner, Ludwig Institute for Cancer Research, USA
Mechanisms of Gross Chromosomal Rearrangements
Short Talk(s) Chosen from Abstracts
Topological Transformations in DNA
Phoebe Rice*, University of Chicago, USA
Structure and Function of Site-Speciic Resolvases
Camilla Sjgren, Karolinska Institutet, Sweden
Regulation of DNA Topology
Claire Wyman, Erasmus Medical Center, Netherlands
Single-Molecule Analysis of DNA Pairing
Short Talk Chosen from Abstracts
THURSDAY, MARCH 7
Replication Elongation Machineries
David J. Sherratt, University of Oxford, UK
High-Resolution in vivo Analysis of Bacterial Chromosome Replication
and Recombination
Peter M. Burgers*, Washington University School of Medicine, USA
Structure and Fidelity of DNA Polymerases at the Replication Fork
Stephen D. Bell, University of Oxford, UK
Archaeal DNA Replication
Linda B. Bloom, University of Florida, USA
Clamp Loading Mechanisms
Short Talk(s) Chosen from Abstracts
Workshop 4: Enzymes Acting on Nucleic Acids (Joint)
Short Talks Chosen from Abstracts
Replicating Challenging Regions
Julia Promisel Cooper, London Research Institute, UK
Coordination of Telomeric Replication Fork Passage and Telomerase Activity
Virginia A. Zakian*, Princeton University, USA
Helicases that Promote Fork Progression
Joachim Lingner, EPFL, Switzerland
Telomeres and the Regulation of Telomerase
Short Talk Chosen from Abstracts
FRIDAY, MARCH 8: DEPARTURE
*Session Chair
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract online
by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
42
GENOMIC INSTABILITY
AND DNA REPAIR
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X6.
DEADLINES FOR BOTH CONFERENCES:
ABSTRACT & SCHOLARSHIP NOV 7, 2012
LATE-BREAKING ABSTRACT DEC 4, 2012
DISCOUNTED REGISTRATION JAN 7, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13X5 or /13X6
Scientic Organizers: Stephen P. Jackson, Alan D. DAndrea and Susan M. Gasser
Registering for one conference in a set of joint conferences enables
participation in sessions of the other, pending space availability.
SUNDAY, MARCH 3: ARRIVAL & REGISTRATION
Keynote Session (Joint)
Frederick W. Alt, HHMI/Childrens Hospital Boston and Immune Disease
Institute, USA
Mechanisms of Normal and Aberrant Recombination and Repair Processes
in Lymphocytes
Kenneth J. Marians, Memorial Sloan-Kettering Cancer Center, USA
Mechanisms of Replication Restart
MONDAY, MARCH 4
Mechanisms and Control of DNA Repair/Mechanisms
of Homologous Recombination (Joint)
Stephen C. Kowalczykowski, University of California, Davis, USA
Single-Molecule Analysis of Recombination
Maria Jasin, Memorial Sloan-Kettering Cancer Center, USA
Control of DNA Repair by BRCA1 and BRCA2
Wolf-Dietrich Heyer, University of California, Davis, USA
Mechanisms of Regulating Recombination
Roland Kanaar, Erasmus University, Netherlands
Mechanism and Control of Homologous Recombination
Short Talk(s) Chosen from Abstracts
Chromosomal Stability, Instability and Nuclear Architecture
Jiri Lukas, Danish Cancer Society, Denmark
DNA Repair and Chromosomal Fragility
Evi Soutoglou, Institute of Genetics and Molecular and Cellular
Biology, France
Nuclear Architecture and Responses to DNA Damage
Speaker to be Announced
Short Talk Chosen from Abstracts
TUESDAY, MARCH 5
Controlling DNA Damage Responses by Ubiquitylation
and Sumoylation
Daniel Durocher, Samuel Lunenfeld Research Institute,
Mount Sinai Hospital, Canada
Ubiquitylation Control of Double-Strand Break Responses
Stephen P. Jackson, University of Cambridge, UK
Assembly and Disassembly of DNA Repair Complexes
by Regulated Ubiquitylation
Dana Branzei, FIRC Institute of Molecular Oncology, Italy
Sumoylation at the DNA Replication Fork
Alan D. DAndrea, Dana-Farber Cancer Institute, USA
Fanconi Anemia Pathway and its Control by Ubiquitylation
Short Talk(s) Chosen from Abstracts
Workshop 1: DNA-Damage Checkpoint Signaling
Short Talks Chosen from Abstracts
Replication, Chromatin and Genome Instability (Joint)
Genevive Almouzni Centie National ue la Recheiche Scientiique Fiance
Recombinational Repair and Heterochromatin
Ian D. Hickson, University of Copenhagen, Denmark
Processing of Late Replication Intermediates
Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research,
Switzerland
Chromatin, DNA Damage and DNA Replication
Short Talk Chosen from Abstracts
WEDNESDAY, MARCH 6
Genome Instability, Telomeres, Disease and Aging
Titia de Lange, Rockefeller University, USA
Telomeres and Responses to DNA Damage
Jan H. J. Hoeijmakers, Erasmus, Netherlands
The Central Role of DNA in Cancer, Aging and Longevity
Laura J. Niedernhofer, University of Pittsburgh Cancer Institute, USA
XPF and its Links to Cancer and Aging
Keith W. Caldecott, University of Sussex, UK
DNA Repair Defects Associated with Neurodegenerative Diseases
Short Talk(s) Chosen from Abstracts
DNA Damage and Links to Transcription, RNA Metabolism
and Other Processes
Andrs Aguilera, Andalusian Molecular Biology and Regenerative Medicine
Centre, Spain
Transcription-Induced DNA Damage and Recombination
Michael B. Yaffe, Massachusetts Institute of Technology, USA
RNA and RNA Binding Proteins in the DNA Damage Response
Karlene A. Cimprich, Stanford University, USA
Transcription-Induced Genome Instability
Short Talk Chosen from Abstracts
THURSDAY, MARCH 7
Genomic and Genome-Wide Studies
Michael Stratton, Wellcome Trust Sanger Institute, UK
Genome Instability in Cancer
David Cortez, Vanderbilt University Medical Center, USA
Identiication and Characterization of Mammalian Genome Maintenance
Proteins
Marcel Tijsterman, Leiden University Medical Center, Netherlands
C. elegans Screens for Genome Instability and DNA Repair Factors
Trey Ideker, University of California, San Diego, USA
A Conserved Map of Genetic Interactions Induced by DNA Damage
Short Talk(s) Chosen from Abstracts
Workshop 2: Enzymes Acting on Nucleic Acids (Joint)
Short Talks Chosen from Abstracts
Diagnostic and Therapeutic Applications
Thomas Helleday, Karolinska Institutet, Sweden
Therapeutic Strategies for Cancer Based on DNA Repair Inhibition
Jos Jonkers, Netherlands Cancer Institute, Netherlands
DDR-Based Therapeutic Strategies and Resistance Mechanisms
scar Fernndez-Capetillo, Centro Nacional de Investigaciones
Oncologicas, Spain
Targeting Oncogene-Induced Replication Stress for Cancer Therapy
Short Talk Chosen from Abstracts
FRIDAY, MARCH 8: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract online
by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
43
GROWING TO EXTREMES:
CELL BIOLOGY AND PATHOLOGY OF AXONS
MARCH 1015, 2013
GRANLIBAKKEN RESORT, TAHOE CITY, CALIFORNIA, USA
(venue information on page 27)
DEADLINES:
ABSTRACT & SCHOLARSHIP NOV 8, 2012
LATE-BREAKING ABSTRACT DEC 10, 2012
DISCOUNTED REGISTRATION JAN 10, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13C4
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C4.
Scientic Organizers: Valeria Cavalli, Michael Fainzilber and Jeffery L. Twiss
SUNDAY, MARCH 10: ARRIVAL & REGISTRATION
MONDAY, MARCH 11
Axonal Speciication, Cytoskeleton
and Compartmentalization
Frank Bradke, German Center for Neurodegenerative
Diseases, Germany
Intracellular Mechanisms of Axonal Growth and Regeneration
Matthew N. Rasband, Baylor College of Medicine, USA
The Axon Initial Segment and the Maintenance of Neuronal Polarity
Franck Polleux, The Scripps Research Institute, USA
Molecular Mechanisms Specifying Cortical Neuron Polarity in vivo
Kozo Kaibuchi, Nagoya University Graduate School of Medicine, Japan
Neuronal Polarity in vitro and in vivo
Short Talk(s) Chosen from Abstracts
Axonal Growth Modalities
Michael Fainzilber, Weizmann Institute of Science, Israel
Motor-Driven Frequency-Based Mechanisms for Axon Growth Control
Douglas H. Smith, University of Pennsylvania, USA
The Role of Dynamic Stretch Injury in Growth and Degeneration
Britta J. Eickholt, Charit Universittsmedizin Berlin, Germany
Talk Title to be Determined
Short Talk Chosen from Abstracts
TUESDAY, MARCH 12
Molecular Motors and Axonal Transport Regulation
Richard Vallee, Columbia University, USA
Regulation of Cytoplasmic Dynein Motor Function
Erika Holzbaur, University of Pennsylvania, USA
Regulation of Dynein-Dependent Retrograde Transport in Health
and Disease Models
Valeria Cavalli, Washington University, USA
Kinesin-1-Dependent Transport in Axon Growth and Regeneration
Frdric Saudou, Institut Curie, France
Role of Huntingtin in Vesicular Traficking along Axons
Short Talk(s) Chosen from Abstracts
Workshop
Short Talks Chosen from Abstracts
Axonal Membrane Dynamics and Organelle Transport
Giampietro Schiavo, London Research Institute, UK
In vivo Imaging of Axonal Transport in Health and Disease
Rejji Kuruvilla, Johns Hopkins University, USA
Regulation of Neuronal Development by Traficking of Neurotrophins
and their Receptors
Thomas L. Schwarz, Childrens Hospital Boston and Harvard
Medical School, USA
Regulating Mitochondrial Movement along Axons in Health and Disease
Short Talk Chosen from Abstracts
WEDNESDAY, MARCH 13
RNA Targeting and Local Translation
Jeffery L. Twiss, Drexel University, USA
mRNAs Compete for Limited Quantities of Transport Machinery
Antonella Riccio, University College London, UK
Neurotrophin-Dependent RNA Transport in Axons
James Fawcett, University of Cambridge, UK
Developmental Regulation of the Axonal mRNA Repertoire
Mustafa Sahin, Childrens Hospital Boston, USA
TSC-mTOR Signaling Regulates Axonal mRNA Translation
Short Talk(s) Chosen from Abstracts
Axonal Signaling
David G. Ginty, Johns Hopkins University School of Medicine, USA
Organization and Development of Neurons that Underlie the Sense of Touch
Gary R. Lewin, Max Delbrck Center for Molecular Medicine, Germany
Signaling Touch and Pain in the Peripheral Nervous System
Mark H. Tuszynski, University of California, San Diego, USA
From Neuronal Signaling to Axon Regeneration
Short Talk Chosen from Abstracts
THURSDAY, MARCH 14
Axonal Maintenance
Christine Beattie, Ohio State University, USA
Mechanisms of Motoneuron Dysfunction from Zebraish to Humans
Avraham Yaron, Weizmann Institute of Science, Israel
Mechanisms of Axonal Maintenance and Degeneration
Joe Lewcock, Genentech, Inc., USA
Intracellular Pathways that Underlie Neurodegeneration
in Development and Disease
Guo-li Ming, Johns Hopkins University, USA
Talk Title to be Determined
Short Talk(s) Chosen from Abstracts
Axon-Glia Interactions
Klaus-Armin Nave, Max Planck Institute of Experimental
Medicine, Germany
The Role of Glia in Axonal Development and Maintenance
Bruce D. Carter, Vanderbilt University School of Medicine, USA
Molecular Mechanisms of Peripheral Myelin Formation
Short Talk Chosen from Abstracts
Closing Keynote Address
Martin E. Schwab, University of Zurich, Switzerland
Axon Growth and Regeneration, from Basic to Clinic
FRIDAY, MARCH 15: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
44
KEYSTONE RESORT
KEYSTONE, COLORADO, USA
FAIRMONT THE QUEEN ELIZABETH
MONTREAL, QUEBEC, CANADA
HILTON SANTA FE HISTORIC PLAZA HOTEL
SANTA FE, NEW MEXICO, USA
Local elevation: 9280 (2828 m)
Local airport/distance to venue: Denver International (DEN)/
90 mi (145 km)
Local elevation: 130 (40 m)
Local airport/distance to venue: Montreal-Pierre Elliott Trudeau
International (YUL)/12 mi (19 km)
Local elevation: 7000 (2134 m)
Local airports/distances to venue: Albuquerque International Sunport
ABQ mi km Santa Fe Nunicipal SAF mi km
FAIRMONT BANFF SPRINGS
BANFF, ALBERTA, CANADA
Local elevation: 4593 (1400 m)
Local airport/distance to venue: Calgary International (YYC)/
90 mi (144 km)
WHISTLER CONFERENCE CENTRE
WHISTLER, BRITISH COLUMBIA, CANADA
Local elevation: 2200 (671 m)
Local airport/distance to venue: Vancouver International (YVR)/
70 mi (115 km)
ELDORADO HOTEL & SPA
SANTA FE, NEW MEXICO, USA
Local elevation: 7000 (2134 m)
Local airports/distances to venue: Albuquerque International Sunport
ABQ mi km Santa Fe Nunicipal SAF mi km
45
HOST RESPONSE
IN TUBERCULOSIS
MARCH 1318, 2013
WHISTLER CONFERENCE CENTRE, WHISTLER, BRITISH COLUMBIA, CANADA
(venue information on page 45)
Scientic Organizers: Andrea M. Cooper and Robert J. Wilkinson
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X7.
JOINT WITH...
WEDNESDAY, MARCH 13: ARRIVAL & REGISTRATION
THURSDAY, MARCH 14
How Do Innate Cells Respond to Mtb (I)
Larry S. Schlesinger, Ohio State University, USA
Early Lung Responses
Jennifer Philips, New York University School of Medicine, USA
EsxH ESCRTs TB to Safety by Arresting Phagosome Maturation
Speaker to be Announced
Short Talks Chosen from Abstracts
Keynote Address TB: The Continuing Challenge (Joint)
Chris Dye, World Health Organization, Switzerland
Population Dynamics and Control of Tuberculosis
How Do Innate Cells Respond to Mtb (II) (Joint)
Carl F. Nathan, Weill Cornell Medical College, USA
Mtb Needs a Strong Host Immune Response But Not Too Strong:
Mechanisms of Mycobacterial Immunomodulation
Anne OGarra, MRC National Institute for Medical Research, UK
Immune Responses in Tuberculosis:
From Mouse Models to Human Disease
David G. Russell, Cornell University, USA
Intracellular Survival by Mycobacterium: No Pressure!
FRIDAY, MARCH 15
Acquired Immunity Beyond the CD4 T Cell/
Macrophage Paradigm?
Peter Andersen, Statens Serum Institut, Denmark
Vaccine-Induced Protection
Samuel M. Behar, Brigham and Womens Hospital, USA
CD8 T Cells in TB
Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA
Innate and Acquired Response to Pathogenic Organisms
Short Talks Chosen from Abstracts
Workshop 1: Host
Short Talks Chosen from Abstracts
Vaccination Against Mtb (Joint)
Daniel A. Portnoy, University of California, Berkeley, USA
Vaccines for Intracellular Pathogens
Thomas G. Evans, Aeras Global TB Vaccine Foundation, USA
Early Results of Vaccine Trials in Humans
Stefan H.E. Kaufmann, Max Planck Institute for Infection
Biology-Berlin, Germany
Current Vaccines
SATURDAY, MARCH 16
The Consequences of the Immune Response in the Lung
Denise Kirschner, University of Michigan, USA
A Systems Biology Approach to Uncovering Mechanisms Governing
Host-Mycobacterial Interactions during TB Infection
Jon Friedland, Imperial College London, UK
Matrix Metalloproteinases in TB
Clifton E. Barry III, NIAID, National Institutes of Health, USA
The Dynamics of Human Tuberculosis
Short Talks Chosen from Abstracts
Workshop 2: Bacteria
Short Talks Chosen from Abstracts
A Global View of Infection (Joint)
Sebastien Gagneux, Swiss Tropical and Public Health Institute,
Switzerland
Evolution of TB
Speaker to be Announced
Kanury V. S. Rao, International Centre for Genetic Engineering
and Biotechnology, India
Host Factors in Resistance
SUNDAY, MARCH 17
Tuberculosis and HIV
Robert J. Wilkinson, University of Cape Town, South Africa
The Effect of HIV-1 Infection on the Human Immune Response to
Mycobacterium tuberculosis
JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Modeling HIV-TB Immune Interaction in Non-Human Primates
Daniel L. Barber, NIAID, National Institutes of Health, USA
Experimental Models of Pathogenic Immune Restoration in Tuberculosis
Richard A. Koup, NIAID, National Institutes of Health, USA
HIV-Tuberculosis Interaction
Short Talk(s) Chosen from Abstracts
Host Susceptibility to Disease (Joint)
Hardy Kornfeld, University of Massachusetts Medical School, USA
Diabetes and TB
Erwin Schurr, Montreal General Hospital, McGill University, Canada
Host Susceptibility to Mtb
Jean-Laurent Casanova, Rockefeller University, USA
Mendelian Susceptibilty to Mycobacteria
MONDAY, MARCH 18: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
46
TUBERCULOSIS:
UNDERSTANDING THE ENEMY
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X8.
DEADLINES FOR BOTH CONFERENCES:
GLOBAL HEALTH TRAVEL AWARD OCT 16, 2012
ABSTRACT & SCHOLARSHIP NOV 13, 2012
LATE-BREAKING ABSTRACT DEC 11, 2012
DISCOUNTED REGISTRATION JAN 14, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13X7 or /13X8
Scientic Organizers: Eric J. Rubin, Sebastien Gagneux and Heran Darwin
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Registering for one conference in a set of joint conferences enables
participation in sessions of the other, pending space availability.
WEDNESDAY, MARCH 13: ARRIVAL & REGISTRATION
THURSDAY, MARCH 14
Mycobacterium tuberculosis From Single Cells to Systems
John D. McKinney, cole Polytechnique Fdrale de Lausanne,
Switzerland
Single Cell Division Cycle Dynamics and Stress Responses
Veronique Anne Dartois, Novartis Institute of Tropical Diseases,
Singapore
Pharmacology, from Single Cells to Organisms
Johnjoe McFadden, University of Surrey, UK
Systems-Based Metabolic Analysis of Intracellular Growth
Short Talks Chosen from Abstracts
Keynote Address TB: The Continuing Challenge (Joint)
Chris Dye, World Health Organization, Switzerland
Population Dynamics and Control of Tuberculosis
How Do Innate Cells Respond to Mtb (II) (Joint)
Carl F. Nathan, Weill Cornell Medical College, USA
Mtb Needs a Strong Host Immune Response But Not Too Strong:
Mechanisms of Mycobacterial Immunomodulation
Anne OGarra, MRC National Institute for Medical Research, UK
Immune Responses in Tuberculosis:
From Mouse Models to Human Disease
David G. Russell, Cornell University, USA
Intracellular Survival by Mycobacterium: No Pressure!
FRIDAY, MARCH 15
Mycobacterial Diversity and Disease
Nico C. Gey van Pittius, University of Stellenbosch, South Africa
Evolution of the PE/PPE Proteins in Mycobacteria
Thomas Ioerger, Texas A&M University, USA
What Comparative Genomics of Mycobacteria Can Tell Us About
Drug Resistance
Jeffery S. Cox, University of California, San Francisco, USA
Toxin-Anti-Toxin Systems and Persistence
Short Talks Chosen from Abstracts
Vaccination Against Mtb (Joint)
Daniel A. Portnoy, University of California, Berkeley, USA
Vaccines for Intracellular Pathogens
Thomas G. Evans, Aeras Global TB Vaccine Foundation, USA
Early Results of Vaccine Trials in Humans
Stefan H.E. Kaufmann, Max Planck Institute for Infection
Biology-Berlin, Germany
Current Vaccines
SATURDAY, MARCH 16
Life and Death in Mycobacteria
Eric J. Rubin, Harvard School of Public Health, USA
Protein Degradation and Pathogenesis
Valerie Mizrahi, University of Cape Town, South Africa
Vitamin B12 Metabolism in Mycobacteria
Heran Darwin, New York University School of Medicine, USA
Pedal to the Metal: Copper Resistance during Mtb Infections
Graham F. Hatfull, University of Pittsburgh, USA
Phages as Probes for Mycobacterial Physiology
A Global View of Infection (Joint)
Sebastien Gagneux, Swiss Tropical and Public Health Institute,
Switzerland
Evolution of TB
Speaker to be Announced
Kanury V. S. Rao, International Centre for Genetic Engineering
and Biotechnology, India
Host Factors in Resistance
SUNDAY, MARCH 17
The Bacterial Surface and its Interaction with the Host
Mary Jackson, Colorado State University, USA
Lipid and Carbohydrate Metabolism in Mycobacteria
Keith M. Derbyshire, Wadsworth Center, New York State Department
of Health, USA
Mycobacterial Protein Secretion
Michael Niederweis, University of Alabama at Birmingham, USA
Mycobacterial Porins
Short Talks Chosen from Abstracts
Host Susceptibility to Disease (Joint)
Hardy Kornfeld, University of Massachusetts Medical School, USA
Diabetes and TB
Erwin Schurr, Montreal General Hospital, McGill University, Canada
Host Susceptibility to Mtb
Jean-Laurent Casanova, Rockefeller University, USA
Mendelian Susceptibilty to Mycobacteria
MONDAY, MARCH 18: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
47
PRECISION GENOME ENGINEERING
AND SYNTHETIC BIOLOGY:
DESIGNING GENOMES AND PATHWAYS
MARCH 1722, 2013
BEAVER RUN RESORT, BRECKENRIDGE, COLORADO, USA
(venue information on page 27)
DEADLINES:
ABSTRACT & SCHOLARSHIP NOV 14, 2012
LATE-BREAKING ABSTRACT DEC 19, 2012
DISCOUNTED REGISTRATION JAN 17, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13C5
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C5.
Scientic Organizers: Dana Carroll and Jef D. Boeke
Sponsored by Sangamo BioSciences, Inc.
SUNDAY, MARCH 17: ARRIVAL & REGISTRATION
MONDAY, MARCH 18
Keynote Address
Frances H. Arnold, California Institute of Technology, USA
Evolutionary Engineering of Proteins and Pathways
Pathway Engineering
Douglas Densmore, Boston University, USA
Clotho CAD for Synthetic Biology
Stephen del Cardayre, LS9, Inc., USA
Engineering E. coli Fatty Acid Metabolism for Sustainable Fuel
and Chemical Production
Ron Weiss, Massachusetts Institute of Technology, USA
Synthetic Biology: From Parts to Modules to Therapeutic Systems
Short Talk(s) Chosen from Abstracts
Zinc-Finger Nucleases and TALENs
Dana Carroll, University of Utah School of Medicine, USA
Parameters Affecting ZFN- and TALEN-Mediated Gene Targeting
Daniel Voytas, University of Minnesota, USA
ZFNs and TALENs in Plants
Thomas Lahaye, Ludwig-Maximilians-University Munich, Germany
TALEs and TALENs: New Tools for Genome Editing
and Transcriptome Modulation
Toni Cathomen, Hannover Medical School, Germany
Comparing ZFNs and TALENs
TUESDAY, MARCH 19
Engineering Genomes
Daniel Gibson, J. Craig Venter Institute, USA
Synthetic Microbial Genomes
Farren Isaacs, Yale University, USA
Programming Genomes to Re-Engineer Lifes Functional Repertoire
Sriram Kosuri, Wyss Institute, USA
Reading and Writing DNA
Jef D. Boeke, Johns Hopkins University School of Medicine, USA
Synthetic Yeast Genome
Short Talk(s) Chosen from Abstracts
Genome Engineering in Humans and Other Animals
Philip D. Gregory, Sangamo BioSciences, Inc., USA
Clincal Trials with ZFNs
Detlev Arendt, EMBL Heidelberg, Germany
ZFN-Mediated Gene Targeting in Platynereis, a New Marine
Molecular Model Organism
Scott C. Fahrenkrug, University of Minnesota, USA
Engineering of Food Animal Genomes
Luigi M. Naldini, San Raffaele Telethon Institute, Italy
Gene Targeting in Human Stem Cells by ZFNs
WEDNESDAY, MARCH 20
Design in Synthetic Biology
Tanja Kortemme, University of California, San Francisco, USA
Computational Design of Proteins, Interactions and Networks
Petra Schwille, Institute of Biophysics, Germany
Design Features of Protein Gradient and Pattern Formation
Jason Chin, MRC, Laboratory of Molecular Biology, UK
Building on Orthogonal Translational Apparatus
Yaakov (Kobi) Benenson, ETH Zrich, Switzerland
Designing Anti-Cancer Circuits Based on miRNA Expression Patterns
Short Talk(s) Chosen from Abstracts
Targeting with Transposons, Integrases
and Homing Endonucleases
Nancy L. Craig, Johns Hopkins University School of Medicine, USA
Transposon Target Selection
Michele P. Calos, Stanford University School of Medicine, USA
Integrase-Mediated Gene Addition to Create and Correct Induced
Pluripotent Stem Cells
Barry Stoddard, Fred Hutchinson Cancer Research Center, USA
Engineered Homing Endonucleases for Gene Targeting via Single- and
Double-Strand Breaks
Short Talk Chosen from Abstracts
THURSDAY, MARCH 21
Programming Organismal Behavior
Virginia W. Cornish, Columbia University, USA
Co-Opting Cells for Directed Evolution
Jeff Hasty, University of California, San Diego, USA
Engineered Gene Circuits: From Oscillators to Synchronized Clocks
and Biopixels
Christopher Voigt, University of California, San Francisco, USA
Programming Devices and Networks
June I. Medford, Colorado State University, USA
Synthetic Signal Transduction and Design of New Traits
Short Talk(s) Chosen from Abstracts
Engineering Biofuel and Specialty Chemical Production
Sang Yup Lee, Korea Advanced Institute of Science and Technology
(KAIST), South Korea
Redesigning Cellular Metabolism for Chemicals Production
Edward M. Rubin, Lawrence Berkeley National Laboratory, USA
Synthetic Metagenomics
Zach Serber, Amyris, USA
Engineering Biofuel and Specialty Chemical Platforms in Yeast
Short Talk Chosen from Abstracts
FRIDAY, MARCH 22: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
48
NEURONAL CONTROL OF APPETITE,
METABOLISM AND WEIGHT
MARCH 1722, 2013
FAIRMONT BANFF SPRINGS, BANFF, ALBERTA, CANADA
(venue information on page 45)
DEADLINES:
ABSTRACT & SCHOLARSHIP NOV 14, 2012
LATE-BREAKING ABSTRACT DEC 19, 2012
DISCOUNTED REGISTRATION JAN 17, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13C6
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C6.
Scientic Organizers: Tony K.T. Lam and Matthias H. Tschp
SUNDAY, MARCH 17: ARRIVAL & REGISTRATION
MONDAY, MARCH 18
Keynote Address
Richard Palmiter, University of Washington, USA
Hypothalamic Inlammation, ER Stress
and Mitochondrial Function
Gkhan S. Hotamisligil, Harvard University, USA
ER Stress and Control of Metabolism
Dongsheng Cai, Albert Einstein College of Medicine, USA
Autophagy and Inlammation in Hypothalamic Neurons and Central
Control of Metabolism
Umut Ozcan, Childrens Hospital Boston, Harvard Medical School, USA
Hypothalamic Inlammation, ER Stress and Metabolic Control
Jens C. Brning, Institute for Genetics, University of Cologne, Germany
Insulin Receptors in the Brain: Where Do They Matter?
Short Talk(s) Chosen from Abstracts
Workshop 1: Is the CNS Still a Relevant Pharmaceutical
Target for Metabolic Disease?
Addiction and Reward in the CNS Control of Metabolism
Jeffrey M. Friedman, Rockefeller University, USA
Neuroendocrine Control of Hedonic Feeding Behavior
Tamas L. Horvath, Yale University School of Medicine, USA
A Role for the Arcute Nucleus in Reward and Complex Behaviors
Dana M. Small, Yale University School of Medicine, USA
Imaging Addiction to Food in Humans
Short Talk Chosen from Abstracts
TUESDAY, MARCH 19
Nutrient Sensing and the Brain
Daniele Piomelli, University of California, Irvine, USA
Lipid Sensing and the Gut-Brain Axis
Tony K.T. Lam, University of Toronto, Canada
Nutrient Sensing in the Gut and the Brain
Bradford B. Lowell, Beth Israel Deaconess Medical Center, USA
Circuits Regulating Energy Balance Functional Dissection and Role
of Synaptic Mechanisms
Sabrina Diano, Yale University School of Medicine, USA
Glucose Sensing and Hypothalamic Neuropeptide Processing
Short Talk(s) Chosen from Abstracts
Workshop 2: Challenges of the Publishing Process:
How to Write a Scientiic Masterpiece
Dissecting CNS Control of Metabolism I
Kendra K. Bence, University of Pennsylvania, USA
The Role of Phosphatase in the Neuronal Control of Energy Balance
Christoph Buettner, Mount Sinai School of Medicine, USA
CNS Control of Fat Metabolism
Scott Sternson, HHMI/Janelia Farm Research Campus, USA
A Novel Hypothalamic Memory Switch in the Regulation
of Energy Homeostasis
Short Talk Chosen from Abstracts
WEDNESDAY, MARCH 20
Gut-Brain Interactions in the Control of Systemic Metabolism
Daniel J. Drucker, Samuel Lunenfeld Research Institute, Canada
The Biology of Incretins: Pleiotropic Metabolic Actions in Health
and Disease
Remy G. Burcelin, Institute of Molecular Medicine, France
The Role of GLP-1 for the Gut-Brain Axis
Richard D. DiMarchi, Indiana University, USA
Novel Drug Treatments for Metabolic Disease:
From Gut Hormones to Polypharmacy
Rachel L. Batterham, University College London, UK
Gut Peptide and Gastric Bypass Surgeries in Type 2 Diabetes
Short Talk(s) Chosen from Abstracts
Workshop 3: Novel Methodological Approaches to the Study
of CNS Control of Metabolism
Short Talks Chosen from Abstracts
Dissecting CNS Control of Metabolism II
Domenico Accili, Columbia University, USA
FoxO1 Targets Regulating Energy Balance in the Central Nervous System
Randy J. Seeley, University of Cincinnati, USA
CNS PPAR-
Markus Stoffel, Institute of Molecular Systems Biology, Switzerland
CNS Foxa2
Short Talk Chosen from Abstracts
THURSDAY, MARCH 21
Neurocircuitry and Systemic Control of Metabolism
Lori M. Zeltser, Columbia University, USA
Hypothalamic Development and Systemic Control of Metabolism
Martin G. Myers, Jr., University of Michigan, USA
Leptin Receptors in the Brain: Where Do They Matter?
Michael A. Cowley, Monash University, Australia
Leptin Modulation of DMH Circuits Controlling the Sympathetic
Nervous System
Roberto Coppari, University of Texas Southwestern Medical Center, USA
Metabolic Actions of Hypothalamic SIRT1
Short Talk(s) Chosen from Abstracts
Glia Cells and CNS Control of Metabolism
Michael W. Schwartz, University of Washington, USA
Hypothalamic Inlammation:
"Primum movens of the Metabolic Syndrome?
Matthias H. Tschp, University of Cincinnati Genome Research
Institute Obesity Research Center, USA
A Role for Hypothalamic Astrocytes in Obesity and Diabetes
Licio A. Velloso, University of Campinas, Brazil
A Role for Hypothalamic Microglia in Obesity and Diabetes
Short Talk Chosen from Abstracts
FRIDAY, MARCH 22: DEPARTURE
This conference will also feature poster sessions, providing excellent opportunities
to network and discuss your research. Submit your abstract online by the
deadlines listed above for the chance to present during one of these poster
sessions, or a plenary session or workshop.
49
RNA SILENCING
MARCH 1924, 2013
WHISTLER CONFERENCE CENTRE, WHISTLER,
BRITISH COLUMBIA, CANADA (venue information on page 45)
DEADLINES:
ABSTRACT & SCHOLARSHIP NOV 15, 2012
LATE-BREAKING ABSTRACT DEC 20, 2012
DISCOUNTED REGISTRATION JAN 18, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13C7
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C7.
Scientic Organizers: David C. Baulcombe and Irene Bozzoni
TUESDAY, MARCH 19: ARRIVAL & REGISTRATION
WEDNESDAY, MARCH 20
Keynote Address
Gary B. Ruvkun, Massachusetts General Hospital, Harvard
Medical School, USA
Posttranscriptional RNA Silencing Pathways
in Diverse Organisms
Elisa Izaurralde, Max Planck Institute for Developmental
Biology, Germany
Mechanisms of miRNA-Mediated Gene Silencing
A. Harel-Bellan, CEA, France
siRNA and Splicing
Craig P. Hunter, Harvard University, USA
Mobile sRNA in C. elegans
Olivier Voinnet, ETH Zrich, Switzerland
RNA Silencing Pathways in Plants
Short Talk Chosen from Abstracts
piRNAs and RNA-Mediated Epigenetic Modiication I
Phillip D. Zamore, University of Massachusetts Medical School, USA
What Fruit Flies Teach Us About RNA Silencing
Haifan Lin, Yale University, USA
Cell Biology Suppression of Phenotypic Variation
Ren F. Ketting, Hubrecht Institute, Netherlands
piRNAs Zebraish
Short Talk Chosen from Abstracts
THURSDAY, MARCH 21
piRNAs and RNA-Mediated Epigenetic Modiication II
Eric A. Miska, University of Cambridge, UK
Small RNA and Transgenerational Effects in Worms
David C. Baulcombe, University of Cambridge, UK
Mobile RNA and Epigenetics in Plants
Nicholas J. Proudfoot, University of Oxford, UK
RNA and Epigenetic Modiication in Mammals
Steven E. Jacobsen, HHMI/University of California, Los Angeles, USA
Plants and Epigenetic Mechanisms
Short Talk(s) Chosen from Abstracts
Long ncRNA
John L. Rinn, Harvard University, USA
Linking RNA to Human Health and Disease
Gordon Simpson, University of Dundee, UK
Long Noncoding RNA in Plants
Speaker to be Announced
Short Talk Chosen from Abstracts
FRIDAY, MARCH 22
ncRNA in Development and Disease I
Speaker to be Announced
Pier Paolo Pandoli, Beth Israel Deaconess Medical Center/Harvard
Medical School, USA
ceRNA Hypothesis
Irene Bozzoni, University La Sapienza, Rome, Italy
Role of Noncoding RNAs in Muscle Differentiation
and in Neuromuscular Disorders
Xavier Estivill, Center for Genomic Regulation and University Pompeu
Fabra, Spain
Neurodegenerative Disease
Short Talk(s) Chosen from Abstracts
ncRNA in Development and Disease II
Robert A. Weinberg

, Whitehead Institute for Biomedical Research, USA


miRNA and Metastasis and Therapeutic Approaches
Speaker to be Announced
Klaus Pantel, Universittsklinikum Hamburg-Eppendorf, Germany
Circulating MicroRNAs as Biomarkers in Cancer Patients
Short Talk Chosen from Abstracts
SATURDAY, MARCH 23
ncRNA in Development and Disease III
Valerio Orlando, Dulbecco Telethon Institute at IRCCS Santa Lucia, Italy
Dicer and Transcription Mechanisms
Lin He, University of California, Berkeley, USA
miRNAs at the Crossroad between Cancer and Reprogramming
Jrgen Kjems, University of Aarhus, Denmark
miRNA Sponges in Human Diseases
Reuven Agami, Netherlands Cancer Institute, Netherlands
miRNA Regulation by RNA-Binding Proteins and Cancer
Short Talk(s) Chosen from Abstracts
RNA Silencing in Virus Disease
Shou-Wei Ding, University of California, Riverside, USA
Induction and Suppression of RNA Silencing during Virus Infection
Bryan R. Cullen, Duke University Medical Center, USA
Viruses and microRNAs
John J. Rossi, Beckman Research Institute of the City of Hope, USA
Small Noncoding RNA Therapies for HIV-1
Short Talk Chosen from Abstracts
SUNDAY, MARCH 24: DEPARTURE

Invited, not yet accepted


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
50
EPIGENETIC MARKS
AND CANCER DRUGS
MARCH 2025, 2013
ELDORADO HOTEL & SPA, SANTA FE, NEW MEXICO, USA
(venue information on page 45)
DEADLINES:
ABSTRACT & SCHOLARSHIP NOV 19, 2012
LATE-BREAKING ABSTRACT DEC 21, 2012
DISCOUNTED REGISTRATION JAN 22, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13C8
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C8.
Scientic Organizer: Ali Shilatifard
Sponsored by Celgene Corporation
WEDNESDAY, MARCH 20: ARRIVAL & REGISTRATION
THURSDAY, MARCH 21
Keynote Address
Stuart L. Schreiber, Harvard University, USA
Linking Genetic Features of Human Cancers and Histone-Modifying
Enzymes for Future Cancer Therapies
Chromosome, Chromatin and Transcription I
Shelley L. Berger*, University of Pennsylvania, USA
B. Franklin Pugh, Pennsylvania State University, USA
Nucleosomal Positioning and the Regulation of Gene Expression
Patrick Cramer, University of Munich (LMU), Germany
Structural Insight into the Transcribing RNA Polymerase II
Anne Brunet, Stanford University, USA
Epigenetic Regulation of Aging
Short Talk(s) Chosen from Abstracts
Chromosome, Chromatin and Transcription II
Ali Shilatifard*, Stowers Institute for Medical Research, USA
C. David Allis, Rockefeller University, USA
Beyond the Double Helix: Varying the Histone Code
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Connecting Transcription, Chromatin and Cancer
Bradley R. Cairns, University of Utah, USA
Chromatin Architecture in Gene Expression and Epigenetics
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
RNAi-Dependent Formation of Heterochromatin
FRIDAY, MARCH 22
Polycomb and Trithorax in Gene Expression and Cancer
B. Franklin Pugh*, Pennsylvania State University, USA
Ali Shilatifard, Stowers Institute for Medical Research, USA
Active Chromatin Marks and Human Cancer
Danny F. Reinberg, HHMI/New York University, USA
Repressive Chromatin Marks in Epigenetics and Cancer
Jrg Mller, Max Planck Institute of Biochemistry, Germany
Polycomb Family in Transcriptional Repression and Development
Peter Verrijzer, Erasmus University Medical Center, Netherlands
Polycomb Family of Transcriptional Regulators in Development
Short Talk(s) Chosen from Abstracts
Histone Marks in Development and Cancer
Ramin Shiekhattar*, Wistar Institute, USA
Thomas Jenuwein, Max Planck Institute of Immunobiology
and Epigenetics, Germany
Talk Title to be Determined
Tony Kouzarides, University of Cambridge, UK
Histone Acetylation, Brd4 and Human Leukemia
Alexander (Sasha) Tarakhovsky, Rockefeller University, USA
Ezh2, Histone Methylation and Prostate Cancer
Shelley L. Berger, University of Pennsylvania, USA
Chromatin, Aging and Cancer

SATURDAY, MARCH 23
DNA Methylation in Development and Cancer
Yi Zhang, University of North Carolina at Chapel Hill, USA
DNA Demethylation and Epigenetics
Peter A. Jones, University of Southern California, USA
DNA Methylation and Cancer Therapy
Jean-Pierre Issa, Temple University School of Medicine, USA
Epigenetic Therapy from Bedside to Bench
Short Talks Chosen from Abstracts
Enhancers and ncRNAs in Development and Cancer
Ramin Shiekhattar, Wistar Institute, USA
Long Noncoding RNAs, and Enhancer and Gene Expression
Jeannie T. Lee, Massachusetts General Hospital, USA
Long Noncoding RNAs in Development
Robert Martienssen, Cold Spring Harbor Laboratory, USA
Talk Title to be Determined
Short Talk Chosen from Abstracts
SUNDAY, MARCH 24
Myc, Transcriptional Regulation and Development
Robert N. Eisenman*, Fred Hutchinson Cancer Research Center, USA
Regulation of Cell Function through the Myc Network
Michael D. Cole, Dartmouth Medical School, USA
An Epigenetic Model for Myc-Mediated Repression
Bruno Amati, Italian Institute of Technology, Italy
Epigenome Regulation in Myc-Driven Tumors
James E. Bradner, Dana-Farber Cancer Institute, USA
BET Bromodomain Inhibitors Targeting c-Myc
Short Talk(s) Chosen from Abstracts
Transcription, Chromatin and Epigenetics in Cancer Therapy
Robert N. Eisenman*, Fred Hutchinson Cancer Research Center, USA
Laurie A. Boyer, Massachusetts Institute of Technology, USA
Noncoding Elements and Cell Fate
Robert Gould, Epizyme, Inc., USA
Epigenetic Therapy I
Patrick Trojer, Constellation Pharmaceuticals, USA
Targeting Histone Lysine Methylation in Cancer
Short Talk Chosen from Abstracts
MONDAY, MARCH 25: DEPARTURE
*Session Chair
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
51
MOLECULAR CLOCKWORKS
AND THE REGULATION
OF CARDIO-METABOLIC FUNCTION
APRIL 37, 2013
SNOWBIRD RESORT, SNOWBIRD, UTAH, USA
(venue information on page 27)
DEADLINES:
ABSTRACT & SCHOLARSHIP DEC 3, 2012
LATE-BREAKING ABSTRACT JAN 3, 2013
DISCOUNTED REGISTRATION JAN 28, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13C9
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C9.
Scientic Organizers: Garret A. FitzGerald and Joseph S. Takahashi
WEDNESDAY, APRIL 3: ARRIVAL & REGISTRATION
THURSDAY, APRIL 4
Keynote Address
Eric Schadt Paciic BiosciencesNount Sinai School of Neuicine 0SA
Systems Integration by the Molecular Clock
Clockworks I
Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical
Center, USA
The Molecular Clock
John Hogenesch, University of Pennsylvania School of Medicine, USA
Systems Biology of the Molecular Clock
Michael M. Rosbash, Brandeis University, USA
Regulation of Clock Function in Drosophila
Speaker to be Announced
Clockworks II
Ueli Schibler, University of Geneva, Switzerland
Signaling to Peripheral Clocks
Felix Naef, EPFL, Switzerland
Genome-Wide Regulation of the Mammalian Metabolic Clock
Martha Merrow, University of Groningen, Netherlands
A Molecular Clock in Yeast
FRIDAY, APRIL 5
Cardio-Metabolic I
Speakers to be Announced
Carla B. Green, University of Texas Southwestern Medical Center, USA
Circadian Post-Transcriptional Regulation of Metabolic Pathways
Clockworks III
Erin K. OShea, Harvard University, USA
Timekeeping with a Three-Protein Circadian Clock
Akhilesh Basi Reddy, University of Cambridge, UK
Clockworks Outside the Nucleus
Steve A. Kay, University of California, San Diego, USA
Drug-Dependent Regulation of Clock Function
SATURDAY, APRIL 6
Cardio-Metabolic II
R. Daniel Rudic, Georgia Health Sciences University, USA
The Vascular Biology of the Molecular Clock
Speakers to be Announced
Frank A.J.L. Scheer, Harvard Medical School, USA
Endogenous Biological Rhythms of Cardiovascular Function in Humans
Cardio-Metabolic III
Joseph T. Bass, Northwestern University, USA
Metabolic Consequences of Clock Dysfunction
Amita Sehgal, University of Pennsylvania, USA
Central and Metabolic Impacts of Clock Function in Drosophila
Garret A. FitzGerald, University of Pennsylvania, USA
Cardiometabolic Implications of Peripheral Clocks
SUNDAY, APRIL 7: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
52
ALPBACH CONGRESS CENTRUM
ALPBACH, AUSTRIA
FAIRMONT CHATEAU WHISTLER
WHISTLER, BRITISH COLUMBIA, CANADA
Local elevation: 3280 (1000 m)
Local airports/distances to venue: Innsbruck Kranebitten (INN)/
37 mi (60 km); Munich International (MUC)/105 mi (169 km)
Local elevation: 2200 (671 m)
Local airport/distance to venue: Vancouver International (YVR)/
70 mi (115 km)
BOSTON PARK PLAZA & TOWERS
BOSTON, MASSACHUSETTS, USA
Local elevation: 20 (6 m)
Local airport/distance to venue: Logan International (BOS)/3 mi (5 km)
OURO PRETO, MINAS GERAIS, BRAZIL
VENUE TO BE DETERMINED
Local elevation: 3871 (1180 m)
Local airport/distance to venue: Belo Horizonte/Pampulha Carlos
Drummond de Andrade (PLU)/71 mi (114 km)
CLARION HOTEL SIGN
STOCKHOLM, SWEDEN
HYATT REGENCY MONTEREY
MONTEREY, CALIFORNIA, USA
Local elevation: 35 (11 m)
Local airport/distance to venue: Stockholm Arlanda (ARN)/26 mi (41 km)
Local elevation: 40 (12 m)
Local airports/distances to venue: Monterey Peninsula (MRY)/2 mi
(3 km); San Jose International (SJC)/72 mi (116 km)
53
IMMUNE ACTIVATION IN HIV INFECTION: BASIC
MECHANISMS AND CLINICAL IMPLICATIONS
APRIL 38, 2013
BEAVER RUN RESORT, BRECKENRIDGE, COLORADO, USA (venue information on page 27)
DEADLINES:
GLOBAL HEALTH TRAVEL AWARD NOV 6, 2012
ABSTRACT & SCHOLARSHIP DEC 3, 2012
LATE-BREAKING ABSTRACT JAN 3, 2013
DISCOUNTED REGISTRATION JAN 29, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13D2
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13D2.
Scientic Organizers: Irini Sereti, Michaela Mller-Trutwin,
Damian F.J. Purcell and Mauro Schechter
Supported by the Ofce of AIDS Research, NIH; Sponsored by Sangamo BioSciences, Inc.
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
WEDNESDAY, APRIL 3: ARRIVAL & REGISTRATION
Keynote Session
Mary Carrington, Frederick National Laboratory
for Cancer Research, USA
The Inluence of Immunogenetic Variation on HIV Disease
Michael M. Lederman, Case Western Reserve University, USA
Immune Activation in HIV: Its Not Just the Virus, or Is It?
THURSDAY, APRIL 4
Molecular and Cellular Biology of Immune Activation
Charles R. Mackay, Monash University, Australia
Diet and Gut Microbiota in the Regulation of Immunity
and Gut Epithelial Permeability
Susan Moir, NIAID, National Institutes of Health, USA
B Cells in HIV Pathogenesis
George Kassiotis, National Institute for Medical Research, UK
Mechanisms of Lymphocyte Activation and T Cell-Mediated Pathology
in Mice Infected by Retroviruses
Frank Kirchhoff, University of Ulm, Germany
Possible Role of Viral Properties in HIV-Induced Immune Activation
Short Talk(s) Chosen from Abstracts
Workshop 1: Therapeutic Targets of IA
Short Talks Chosen from Abstracts
HIV Transmission and Acute Infection
Thomas J. Hope, Northwestern University, Feinberg School
of Medicine, USA
Imaging of Viral Dissemination in Cervical Mucus and Role of Ab
Gabriella Scarlatti San Raffaele Scientiic Institute Italy
Early Events of Transmission at the Intestinal Mucosal and Role
of Dendritic Cells
Michaela Mller-Trutwin, Institut Pasteur, France
Innate Immune Responses in the Acute Phase of Non-Pathogenic
SIVagm Infection
Short Talk Chosen from Abstracts
FRIDAY, APRIL 5
Viral Reservoirs and Immune Dysfunction
Michael H. Malim, Kings College London School of Medicine, UK
HIV and Innate Anti-Viral Factors
Monsef Benkirane, Institut de Genetique Humaine, France
Regulation of Cellular Factors Involved in HIV Virus Gene Expression
Damian F.J. Purcell, University of Melbourne, Australia
Mechanisms Taking Virus from Latency to T-Cell Activation
Una ODoherty, University of Pennsylvania Medical Center, USA
Important Differences between HIV Infection of Resting
versus Activated T Cells
Short Talk(s) Chosen from Abstracts
Mucosal Immunity and HIV
Mirko Paiardini, Emory University, YNPRC, USA
Homeostasis of CD4
+
T Cell Subsets in SIV Infection
Jacob D. Estes, SAIC-Frederick, Inc., NCI-Frederick, USA
GI Damage and Immune Activation in SIV
FRIDAY, APRIL 5 (CONTINUED)
Frederic D. Bushman, University of Pennsylvania School
of Medicine, USA
Deep Sequence of the Microbiome in HIV
Short Talk Chosen from Abstracts
SATURDAY, APRIL 6
Immune Activation and Co-Infections
Nina Bhardwaj, New York University School of Medicine, USA
Role of Dendritic Cells and Type I Interferons in HIV Pathogenesis and
Immune Activation
Michael L. Dustin, New York University School of Medicine, USA
Imaging of Immune Synapses, Kinapses vs. Synapses, and Role
in Inlammation
Martyn French, University of Western Australia, Australia
Immune Reconstitution Inlammatory Syndrome in HIV Infection
Richard A. Koup, NIAID, National Institutes of Health, USA
Role of Co-Pathogens in HIV Immune Dysfunction
Short Talk(s) Chosen from Abstracts
Workshop 2: HIV and Aging
Short Talks Chosen from Abstracts
Viral and Host Genes and Genomics
Nabila Seddiki, Vaccine Research Institute and Universit Paris-Est Crteil
(UPEC), France
Role of Treg in HIV Pathogenesis
Javier Martinez-Picado, ICREA and irsiCaixa Foundation, Spain
HIV Persistence and Immune Activation
Philip Tarr, University of Basel, Switzerland
Genetic Associations of Non-Infectious Complications of HIV
Short Talk Chosen from Abstracts
SUNDAY, APRIL 7
Viral and Cellular Aspects of Immune Activation
and Aging under Antiretroviral Therapy
Alan J. Korman, Bristol-Myers Squibb, USA
Immunostimulatory Monoclonal Ab to Reverse Immunosuppression
Irini Sereti, NIAID, National Institutes of Health, USA
Biomarkers in HIV Infection
Ivona Pandrea, University of Pittsburgh, USA
Lessons from Non-Human Primate Models
Speaker to be Announced
Short Talk(s) Chosen from Abstracts
Future Directions in Immune Interventions
Sharon R. Lewin, Alfred Hospital and Monash University, Australia
Bench to Bedside: Where Do We Go from Here?
Mauro Schechter, Universidade Federal do Rio de Janeiro, Brazil
Preventive Efforts, New Directions Beyond Vaccines
Steven G. Deeks, University of California, San Francisco, USA
HIV and Aging: Novel Therapeutic Approaches
MONDAY, APRIL 8: DEPARTURE
This conference will also feature poster sessions, providing excellent opportunities
to network and discuss your research. Submit your abstract online by the
deadlines listed above for the chance to present during one of these poster
sessions, or a plenary session or workshop.
54
NUCLEAR RECEPTORS AND FRIENDS:
ROLES IN ENERGY HOMEOSTASIS
AND METABOLIC DYSFUNCTION
APRIL 38, 2013
ALPBACH CONGRESS CENTRUM, ALPBACH, AUSTRIA
(venue information on page 53)
DEADLINES:
ABSTRACT & SCHOLARSHIP DEC 4, 2012
LATE-BREAKING ABSTRACT JAN 4, 2013
DISCOUNTED REGISTRATION JAN 31, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13D3
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13D3.
Scientic Organizers: Antonio J. Vidal-Puig, Antonio Moschetta and Anastasia Kralli
WEDNESDAY, APRIL 3: ARRIVAL & REGISTRATION
THURSDAY, APRIL 4
Keynote Address
Helen H. Hobbs, University of Texas Southwestern Medical Center, USA
Role of ABC Transporters in Lipid Transport
Nuclear Receptors and Metabolism: Liver and Gut Pathways
Antonio Moschetta, Consorzio Mario Negri Sud, Italy
Regulation of Enterocyte Aging via PGC1
David J. Mangelsdorf, University of Texas Southwestern Medical
Center, USA
Nuclear Receptor/FGF Endocrine Signaling and Metabolism
David D. Moore, Baylor College of Medicine, USA
LRH1, the Gut and the Liver
Michela Plateroti, Universit Claude Bernard Lyon 1, France
Thyroid Receptor and Intestinal Stemness
Nuclear Receptors and Control of Food Intake
Miguel Lpez, Universidad de Santiago de Compostela, Spain
Oestrogen Receptors and Energy Balance
Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
SF1 in VMN and Energy Balance
Tony K.T. Lam, University of Toronto, Canada
Nutrient and Hypothalamus Sensing
Short Talk Chosen from Abstracts
FRIDAY, APRIL 5
Nuclear Receptors and Energy Expenditure Pathways
Anastasia Kralli, The Scripps Research Institute, USA
The Role of The PGC-1/ERR Network in Mitochondrial Function
and BAT Physiology
Antonio J. Vidal-Puig, University of Cambridge, UK
Brown Fat Activity Sensitizers
Krishna Chatterjee, University of Cambridge, UK
Nuclear Receptors and Metabolic Dysfunction:
Insights from Human Genetics
Beatrice Desvergne, University of Lausanne, Switzerland
Too Much or Too Little Fat: Same Metabolic Consequences,
Same Mechanisms?
Short Talk(s) Chosen from Abstracts
Workshop and Round-Table Discussion:
Targeting NRs for the Treatment of Metabolic Disease
Short Talks Chosen from Abstracts
Adipogenesis and Energy Storage
Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard
University, USA
Systems Approaches to Adipogenesis
Juro Sakai, University of Tokyo, Japan
Epigenomic Regulation of Inlammation, Energy Metabolism
and Adipogenesis
Lluis Fajas, INSERM, France
Cell Cycle and Energy Homeostasis
Short Talk Chosen from Abstracts
SATURDAY, APRIL 6
Lipid Metabolic Sensors
Peter Tontonoz, University of California, Los Angeles, USA
Idolizing the LDL Receptor
Karen Reue, University of California, Los Angeles, USA
Lipin Proteins and Cellular Lipid Homeostasis
David Shapiro, Intercept Pharmaceuticals Inc., USA
FXR Agonism From Theory to Practice
Carl S. Thummel, University of Utah School of Medicine, USA
Lipid Metabolism in Flies
Short Talk(s) Chosen from Abstracts
Workshop 2
Short Talks Chosen from Abstracts
Immune System and Metabolism
Mercedes Ricote, Centro Nacional de Investigaciones
Cardiovasculares, Spain
Emerging Roles of RXRs in Macrophage Biology
Ajay Chawla, University of California, San Francisco, USA
Innate Immunity and Metabolism
Inez Rogatsky, Weill Medical College of Cornell University, USA
A Transcriptional Coregulator GRIP1 at the Intersection of Pro-
and Anti-Inlammatory Pathways
Short Talk Chosen from Abstracts
SUNDAY, APRIL 7
Skeletal Muscle, Exercise and Diet
Daniel P. Kelly, Sanford-Burnham Medical Research Institute, USA
Nuclear Receptor miRNA Regulatory Networks
Juleen R. Zierath, Karolinska Institutet, Sweden
Epigenetic Regulation in Response to Exercise
Ronald M. Evans, The Salk Institute, USA
PPARs, ERRs, Muscle
Vincent Gigure, McGill University, Canada
Estrogen-Related Receptors and Control of Energy Metabolic Pathways
Short Talk(s) Chosen from Abstracts
Circadian Clock and Metabolism
Katja A. Lamia, The Scripps Research Institute, USA
Cryptochromes Are NR Co-Repressors
Thomas P. Burris, The Scripps Research Institute, USA
ROR and REV-ERB Regulation of Immune Function and Metabolism
Paolo Sassone-Corsi, University of California, Irvine, USA
Metabolism Control of the Circadian Clock
Short Talk Chosen from Abstracts
MONDAY, APRIL 8: DEPARTURE
This conference will also feature poster sessions, providing excellent opportunities
to network and discuss your research. Submit your abstract online by the
deadlines listed above for the chance to present during one of these poster
sessions, or a plenary session or workshop.
55
IMMUNOPATHOLOGY
OF TYPE 1 DIABETES
APRIL 49, 2013
FAIRMONT CHATEAU WHISTLER, WHISTLER, BRITISH COLUMBIA, CANADA
(venue information on page 53)
Scientic Organizers: Kevan C. Herold, Dario A.A. Vignali, Jeffrey A. Bluestone and Anne Cooke
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13Z1.
JOINT WITH...
THURSDAY, APRIL 4: ARRIVAL & REGISTRATION
Keynote Session (Joint)
Luke A. J. ONeill, Trinity College Dublin, Ireland
Innate Immunity, Inlammation and Autoimmunity
Diane J. Mathis, Harvard Medical School, USA
Control of Autoimmune Diabetes
FRIDAY, APRIL 5
Modulation of Immunity toward Autoimmune Therapy:
From Mouse to Man (Joint)
Dario A. A. Vignali, St. Jude Childrens Research Hospital, USA
Molecular Control of Regulatory Networks in Autoimmunity
Jeffrey A. Bluestone, University of California, San Francisco, USA
Treg Plasticity and Function: Mechanisms and Therapeutic Implications
Richard A. Flavell, Yale University School of Medicine, USA
Humanized Mouse Models in the Study of Autoimmune Diseases
Stephen D. Miller, Northwestern University Medical School, USA
Induction of Immune Tolerance in the Treatment of Autoimmunity
Maria Grazia Roncarolo San Raffaele Scientiic Institute Italy
Disregulation of Immune Response in Genetic
and Acquired Autoimmune Diseases
Short Talk Chosen from Abstracts
Immune Effector/Autoantigens in T1DM
Gerald T. Nepom, Benaroya Research Institute, USA
The T Cell Repertoire in Human Autoimmune Diabetes
Teresa P. DiLorenzo, Albert Einstein College of Medicine, USA
Antigen-Speciic T Cells in NOD Diabetes
Mark Peakman, Kings College London, UK
Pathogenic T Cells in Human T1D
Short Talk Chosen from Abstracts
SATURDAY, APRIL 6
Regulatory and Developmental Control of T1DM
Mark Anderson, University of California, San Francisco, USA
Peripheral Tolerance-AIRE: Whats New, Whats Next?
Steven F. Ziegler, Benaroya Research Institute and University
of Washington School of Medicine, USA
Transcriptional Control of Tregs
Pere Santamaria, University of Calgary, Canada
Maturation and Modulation of CD8+ T Effector Cells
Jane H. Buckner, Benaroya Research Institute at Virginia Mason, USA
T Cell Deregulation in Human T1DM
David A. Haler, Yale School of Medicine, USA
Human Autoimmunity, a Common Genetic Disease(s
Short Talk Chosen from Abstracts
Workshop 1: Basic Research Advances
Short Talks Chosen from Abstracts
Workshop 2: Translational/Clinical Research Advances
Short Talks Chosen from Abstracts
SUNDAY, APRIL 7
The Microlora in the Regulation of Immunity
and Autoimmunity (Joint)
Karen E. Nelson, J. Craig Venter Institute, USA
The Makeup of the Human Microbiome
Alexander Chervonsky, University of Chicago, USA
Microbial Inluence on T1D
Fiona M. Powrie, University of Oxford NDM, UK
Regulation of Colitis by the Gut Microbiome
Mark A. Atkinson, University of Florida, USA
The Gut Microbiome in Diabetes
Lloyd H. Kasper, Dartmouth Medical School, USA
Gut, Bugs and the Brain: The Role of Commensal Bacteria
in CNS Demyelination
Short Talk Chosen from Abstracts
Immune Modulation and Effects of Immune Modulators
on T1DM
Matthias G. von Herrath, La Jolla Institute for Allergy and Immunology, USA
Autoreactive CD8 Cells How Do We Best Control Them to Treat T1D?
Lucienne Chatenoud, INSERM U1013, Hpital Necker-Enfants
Malades, France
Anti-CD3 Therapy
Bart O. Roep, Leiden University Medical Center, Netherlands
Methods and Mechanisms of Immune Modulation in Humans
Short Talk Chosen from Abstracts
MONDAY, APRIL 8
Cellular and Environmental Networks in T1DM
Li Wen, Yale University, USA
Role of TLRs in Regulation of Autoimmunity and Cells in Type 1 Diabetes
Anne Cooke, University of Cambridge, UK
Th17 Cells in T1DM
Agns C. Lehuen, Hpital Saint Vincent de Paul, France
Viral Infections and NKT Cells in Type 1 Diabetes
David V. Serreze, The Jackson Laboratory, USA
To Be or Not to Be: Challenges in B-Lymphocyte-Directed Interventions
for Type 1 Diabetes
George S. Eisenbarth, University of Colorado Health Sciences Center, USA
Autoantigen Presentation in Type 1 Diabetes:
Opportunity for Antigen-Speciic Interventions?
Short Talk Chosen from Abstracts
The Future of T1DM Research and Clinical Translation
Linda S. Wicker, University of Cambridge, UK
IL-2 Therapy for Type 1 Diabetes
Kevan C. Herold, Yale University, USA
Combination Therapies for Type 1 Diabetes
Megan K. Levings, University of British Columbia, Canada
Regulatory T Cell Therapy in Autoimmunity and Transplantation
Short Talk Chosen from Abstracts
TUESDAY, APRIL 9: DEPARTURE
This conference will also feature poster sessions, providing excellent opportunities
to network and discuss your research. Submit your abstract online by the
deadlines listed above for the chance to present during one of these poster
sessions, or a plenary session or workshop.
56
ADVANCES IN THE KNOWLEDGE
AND TREATMENT OF AUTOIMMUNITY
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13Z2.
DEADLINES FOR BOTH CONFERENCES:
ABSTRACT & SCHOLARSHIP DEC 4, 2012
LATE-BREAKING ABSTRACT JAN 4, 2013
DISCOUNTED REGISTRATION FEB 4, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13Z1 or /13Z2
Scientic Organizers: Juan Rivera, Virginia Pascual and David M. Lee
Sponsored by Biogen Idec and MedImmune
Registering for one conference in a set of joint conferences enables
participation in sessions of the other, pending space availability.
THURSDAY, APRIL 4: ARRIVAL & REGISTRATION
Keynote Session (Joint)
Luke A. J. ONeill, Trinity College Dublin, Ireland
Innate Immunity, Inlammation and Autoimmunity
Diane J. Mathis, Harvard Medical School, USA
Control of Autoimmune Diabetes
FRIDAY, APRIL 5
Modulation of Immunity toward Autoimmune Therapy:
From Mouse to Man (Joint)
Dario A. A. Vignali, St. Jude Childrens Research Hospital, USA
Molecular Control of Regulatory Networks in Autoimmunity
Jeffrey A. Bluestone, University of California, San Francisco, USA
Treg Plasticity and Function: Mechanisms and Therapeutic Implications
Richard A. Flavell, Yale University School of Medicine, USA
Humanized Mouse Models in the Study of Autoimmune Diseases
Stephen D. Miller, Northwestern University Medical School, USA
Induction of Immune Tolerance in the Treatment of Autoimmunity
Maria Grazia Roncarolo San Raffaele Scientiic Institute Italy
Disregulation of Immune Response in Genetic and Acquired
Autoimmune Diseases
Short Talk Chosen from Abstracts
Mechanisms of Peripheral and Central Tolerance
John W. Kappler, National Jewish Health, USA
MHC Peptide Registers-MHC Complexity Beyond Peptide
Kristin Tarbell*, NIDDK, National Institutes of Health, USA
The Role of DCs for Antigen-Speciic Tolerance Induction in the Context
of Autoimmune Diabetes
Shannon J. Turley, Dana-Farber Cancer Institute,
Harvard Medical School, USA
Regulation of Dendritic Cell and T Cell Function
by Nonhematopoietic Stroma
Short Talk Chosen from Abstracts
SATURDAY, APRIL 6
Innate Immunity and Autoimmune Disease
Silvia Bolland*, NIAID, National Institutes of Health, USA
TLR7 and Autoimmunity
Virginia Pascual, Baylor Institute for Immunology Research, USA
pDCs and IFN Signature in SLE
Juan Rivera, NIAMS, National Institutes of Health, USA
Basophils in the Ampliication of SLE
Melissa A. Brown, Northwestern University, USA
Mast Cells and Neutrophils in CNS Disease
Short Talk(s) Chosen from Abstracts
Challenges and Lessons from Immunotherapy
Timothy W. Behrens*, Genentech, Inc., USA
Biomarkers for Clinical Trials and the Clinic Where to Next?
Thi-Sau Migone, Human Genome Sciences, USA
Belimumab: What Are We Learning from the Treatment of Lupus?
Robert P. Anderson, Walter and Eliza Hall Institute of Medical
Research, Australia
Celiac Disease Can We Transition from Peptides to Treatment?
Short Talk Chosen from Abstracts
SUNDAY, APRIL 7
The Microlora in the Regulation of Immunity
and Autoimmunity (Joint)
Karen E. Nelson, J. Craig Venter Institute, USA
The Makeup of the Human Microbiome
Alexander Chervonsky, University of Chicago, USA
Microbial Inluence on T1D
Fiona M. Powrie, University of Oxford NDM, UK
Regulation of Colitis by the Gut Microbiome
Mark A. Atkinson, University of Florida, USA
The Gut Microbiome in Diabetes
Lloyd H. Kasper, Dartmouth Medical School, USA
Gut, Bugs and the Brain: The Role of Commensal Bacteria
in CNS Demyelination
Short Talk Chosen from Abstracts
Workshop 1: Basic Mechanisms in Autoimmunity
Short Talk(s) Chosen from Abstracts
Workshop 2: Clinical and Translational Aspects of Autoimmunity
Short Talk(s) Chosen from Abstracts
Lymphocytes in Autoimmunity I B Cells
Eric Meffre, Yale University School of Medicine, USA
Autoreactive B Cells Who, What, Where?
Andreas Radbruch, Deutsches Rheuma-Forschungszentrum,
Berlin, Germany
Plasmablasts vs. Plasma Cells Roles in Autoantibody Production
Thomas F. Tedder, Duke University Medical Center, USA
B Cell Regulation of Immune Responses
Short Talk Chosen from Abstracts
MONDAY, APRIL 8
Lymphocytes in Autoimmunity II T Cells
Federica Sallusto, Institute for Research in Biomedicine, Switzerland
T Cell Subsets in Human Disease
Shigeo Koyasu, Keio University School of Medicine, Japan
Natural Helper Cells in Th2-Type Innate Immunity
Carola G. Vinuesa, Australian National University, Australia
T Follicular Helper Cells during Immunity and Tolerance
Vijay K. Kuchroo, Brigham and Womens Hospital,
Harvard Medical School, USA
Th17 Cells in Tissue Inlammation and Autoimmunity
Short Talk(s) Chosen from Abstracts
Systems Approaches to Autoimmunity
Speaker to be Announced
Edward K. Wakeland, University of Texas Southwestern Medical Center, USA
Genomic Analysis of Systemic Autoimmunity
Atul J. Butte, Stanford University, USA
Personalized and Systems Medicine
Short Talk Chosen from Abstracts
TUESDAY, APRIL 9: DEPARTURE
*Session Chair
This conference will also feature poster sessions, providing excellent opportunities
to network and discuss your research. Submit your abstract online by the
deadlines listed above for the chance to present during one of these poster
sessions, or a plenary session or workshop.
57
CARDIAC REMODELING, SIGNALING,
MATRIX AND HEART FUNCTION
APRIL 712, 2013
SNOWBIRD RESORT, SNOWBIRD, UTAH, USA
(venue information on page 27)
DEADLINES:
ABSTRACT & SCHOLARSHIP DEC 5, 2012
LATE-BREAKING ABSTRACT JAN 9, 2013
DISCOUNTED REGISTRATION FEB 6, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13D4
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13D4.
Scientic Organizers: Anthony J. Muslin, Jil C. Tardiff and Steven R. Houser
Sponsored by Bayer USA Foundation
SUNDAY, APRIL 7: ARRIVAL & REGISTRATION
MONDAY, APRIL 8
Keynote Address
Bruce M. Spiegelman, Harvard Medical School, USA
The Regulation of Physiologic Cardiac Growth by C/EBP
Transcription Factors
Regenerating Injured Myocardium
Deepak Srivastava, Gladstone Institute of Cardiovascular Disease, USA
Genetic Reprogramming of Fibroblasts in the Myocardium
Eric N. Olson, University of Texas Southwestern Medical Center, USA
In situ Generation of Cardiac Myocytes
William T. Pu, Childrens Hospital, Harvard Medical School, USA
Transcriptional Pathways in Cardiac Regeneration
Issei Komuro, Osaka University Graduate School, Japan
Cardiac Angiogenesis and Myogenesis
Bioengineering and Tissue Repair
Joseph C. Wu, Stanford University, USA
Imaging Cardiac Stem Cell Therapy
Richard T. Lee, Harvard University, USA
Bioengineering to Promote Cardiac Regeneration
Josef M. Penninger, Institute of Molecular Biotechnology
GmbH, Austria
Apelin and ACE2 Regulate Cardiac Fibrosis and Function
TUESDAY, APRIL 9
Genetic Causes of Cardiomyopathy
Elizabeth M. McNally, University of Chicago, USA
Modiier Genes for Heart and Muscle Disease
Christine E. Seidman, Harvard Medical School, USA
Cardiac Fibrosis in Hypertrophic Cardiomyopathy
Howard A. Rockman, Duke University Medical Center, USA
The Use of Drosophila Genetic Screens to Investigate Cardiomyopathy
Xuejun Wang, University of South Dakota, USA
Protein Quality Control in Cardiac Proteinopathies
Workshop: Developing Novel Therapeutic Agents
for Heart Failure
Short Talks Chosen from Abstracts
MicroRNA Regulation of Cardiac Function
Gerald W. Dorn, II, Washington University School of Medicine, USA
MicroRNA Regulation of Cardiac Hypertrophy and Failure
Edward E. Morrisey, University of Pennsylvania, USA
MicroRNA-Mediated Programming and Reprogramming
of Somatic Cells
Walter J. Koch, Temple University School of Medicine, USA
Regulation of Cardiac Hypertrophy by GRKs
WEDNESDAY, APRIL 10
Calcium Signaling, Protein Kinases and Cardiac Dysfunction
Joan Heller Brown, University of California, San Diego, USA
Localized Calcium Signaling and CamKII
Steven R. Houser, Temple University School of Medicine, USA
Calcium Inlux Pathways that Regulate Hypertrophy
Jeffery D. Molkentin, Cincinnati Childrens Hospital Medical Center, USA
Calcium Signaling Pathways that Regulate Cardiac Growth
Mark E. Anderson, University of Iowa, USA
Calcium Signaling in Cardiac Arrhythmias
Cardiac Autophagy and Proteolysis
Norbert Perrimon, Harvard Medical School, USA
FoxO and 4EBP Regulation of Drosophila Muscle Physiology
Roberta Gottlieb, San Diego State University, USA
Mitophagy and Cardioprotection
Asa B. Gustafsson, University of California, San Diego, USA
Mitochondrial Autophagy in Ischemic Myocardium
THURSDAY, APRIL 11
Cardiac Mechanics
Fady Malik, Cytokinetics Inc., USA
Cardiac Myosin Activators for the Treatment of Heart Failure
Jil C. Tardiff, University of Arizona, USA
Thin Filament Function in Cardiac Physiology
Henk Granzier, University of Arizona, USA
The Role of Titin in Cardiac Function and Disease
Samantha Harris, University of California, Davis, USA
Cardiac Myosin Binding Protein-C
Cardiac Extracellular Matrix in Disease
Ronglih Liao, Brigham and Womens Hospital, USA
New Insights into Amyloid Cardiomyopathy
Thomas Eschenhagen, University Medical Center Hamburg
Eppendorf, Germany
Cardiac Tissue Engineering
Anthony J. Muslin, Novartis Institutes for BioMedical Research, Inc., USA
Developing Drugs to Reduce Cardiac Fibrosis and Improve Function
FRIDAY, APRIL 12: DEPARTURE
This conference will also feature poster sessions, providing excellent opportunities
to network and discuss your research. Submit your abstract online by the
deadlines listed above for the chance to present during one of these poster
sessions, or a plenary session or workshop.
58
PLANT IMMUNITY:
PATHWAYS AND TRANSLATION
APRIL 712, 2013
BIG SKY RESORT, BIG SKY, MONTANA, USA
(venue information on page 21)
DEADLINES:
ABSTRACT & SCHOLARSHIP DEC 6, 2012
LATE-BREAKING ABSTRACT JAN 10, 2013
DISCOUNTED REGISTRATION FEB 7, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13D5
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13D5.
Scientic Organizers: Sophien Kamoun and Ken Shirasu
SUNDAY, APRIL 7: ARRIVAL & REGISTRATION
MONDAY, APRIL 8
Keynote Address
Paul M. Schulze-Lefert, Max Planck Institute for Plant Breeding
Research, Germany
Structure and Functions of the Plant Bacterial Microbiome
Surface Receptor-Mediated Immunity Recognition
Georg Felix, University of Tbingen, Germany
Recognition of PAMPs and Other Danger Signals by Surface Receptors
Pamela C. Ronald, University of California, Davis, USA
Recognition of Ax21 by Rice Receptor Xa21
Naoto Shibuya, Meiji University, Japan
Chitin Perception in Rice and Arabidopsis
Short Talk(s) Chosen from Abstracts
Workshop 1: Systems Approaches to Plant Immunity
Fumiaki Katagiri*, University of Minnesota, USA
Short Talks Chosen from Abstracts
Surface Receptor-Mediated Immunity Signaling
Cyril Zipfel, Sainsbury Laboratory, UK
PAMP-Triggered Immunity Signaling
Birgit Kemmerling, University of Tbingen, Germany
PAMP-Triggered Immunity Signaling
Hirofumi Yoshioka, Nagoya University, Japan
Roles of MAPK and CDPK in PAMP-Triggered Immunity
TUESDAY, APRIL 9
Intracellular Immunity Recognition
Peter N. Dodds, CSIRO Plant Industry, Australia
Recognition of Rust Effectors by NBS-LRR Proteins
Gitta L. Coaker, University of California, Davis, USA
Activation of Effector Triggered Immunity
Jeffery L. Dangl, University of North Carolina at Chapel Hill, USA
The Plant Immune System: Response to Infection
and Maintenance of Homeostasis
Speaker to be Announced
Short Talk(s) Chosen from Abstracts
Intracellular Immunity Signaling
Peter Moffett, University of Sherbrooke, Canada
NB-LRR-Mediated Anti-Viral Responses
Xin Li, University of British Columbia, Canada
NBS-LRR Signaling
Jonathan D.G. Jones, Sainsbury Laboratory, UK
Disease Resistance Mediated by NB-LRR Pairs
WEDNESDAY, APRIL 10
Suppression of Immunity
Jianmin Zhou, National Institute of Biological Sciences, China
Suppression of PAMP-Triggered Immunity by Bacterial Effectors
Bart P.J. Thomma, Wageningen University, Netherlands
Suppression of Chitin Response
Sophien Kamoun, Sainsbury Laboratory, UK
Suppression of Immunity by Oomycete Effectors
Speaker to be Announced
Short Talk(s) Chosen from Abstracts
Workshop 2: Emerging Pathogens and Pests
Short Talks Chosen from Abstracts
Evolutionary Plant-Microbe Interactions
Detlef Weigel, Max Planck Institute for Developmental Biology, Germany
The Plant Immune System at the Nexus of Trade-Offs Affecting Fitness
and Gene Flow
Wenbo Ma, University of California, Riverside, USA
Effectors of Plant Pathogens
Short Talks Chosen from Abstracts
THURSDAY, APRIL 11
Translating Plant Immunity
Brian J. Staskawicz, University of California, Berkeley, USA
Resistance to Xanthomonads
Eric R. Ward, Two Blades Foundation, USA
Resistance to Rusts
Ken Shirasu, RIKEN, Japan
Striga-Host Interactions
Vivianne Vleeshouwers, Wageningen University, Netherlands
Exploiting Effectors in Resistance Breeding
Short Talk(s) Chosen from Abstracts
Emerging Topics in Plant Immunity
Thomas J. Wolpert, Oregon State University, USA
Victoria Blight: When Defense Becomes Defenseless
Renier A.L. Van der Hoorn, Max Planck Institute for Plant Breeding
Research, Germany
Apoplastic Enzymes and Defense
Silke Robatzek, Sainsbury Laboratory, UK
Cell Biology of Plant Immune Response
FRIDAY, APRIL 12: DEPARTURE
*Session Chair
This conference will also feature poster sessions, providing excellent opportunities
to network and discuss your research. Submit your abstract online by the
deadlines listed above for the chance to present during one of these poster
sessions, or a plenary session or workshop.
59
POSITIVE STRAND
RNA VIRUSES
APRIL 28MAY 3, 2013
BOSTON PARK PLAZA & TOWERS, BOSTON, MASSACHUSETTS, USA
(venue information on page 53)
DEADLINES:
ABSTRACT & SCHOLARSHIP DEC 20, 2012
LATE-BREAKING ABSTRACT JAN 31, 2013
DISCOUNTED REGISTRATION FEB 28, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13D7
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13D7.
SUNDAY, APRIL 28: ARRIVAL & REGISTRATION
MONDAY, APRIL 29
Keynote Address
Herbert (Skip) W. Virgin IV, Washington University School
of Medicine, USA
The Virome and Disease Susceptibility:
More Than One Way To Be a Pathogen (or a friend
Innate Immunity: Sensing and Defending
Takashi Fujita, Institute for Virus Research, Kyoto University, Japan
Sensing Viral RNA and Antiviral Responses
John Schoggins, Rockefeller University, USA
Antiviral Type I Interferon Effectors Targeting RNA Viruses
Margo A. Brinton, Georgia State University, USA
Flavivirus RNA Structure
Short Talk(s) Chosen from Abstracts
Evolution of Viruses in the Environment
Marco Vignuzzi, Pasteur Institut, France
Virus Micro-Evolution and Subpopulations within the Infected Host
Marilyn Roossinck, Pennsylvania State University, USA
The Big Unknown: Plant Virus Biodiversity and Ecosystem Impacts
Raul Andino, University of California, San Francisco, USA
RNA Virus Evolution
Short Talk Chosen from Abstracts
TUESDAY, APRIL 30
Systems Biology of +RNA Virus-Host Interaction
Carolyn B. Coyne, University of Pittsburgh, USA
siRNA Screens for Enteroviruses
Peter D. Nagy, University of Kentucky, USA
Reprogramming Cellular Pathways by Tombusviruses
to Facilitate Replication
Ralf Bartenschlager, University of Heidelberg, Germany
Host Factors in Flavivirus Replication
Lucas Pelkmans, University of Zurich, Switzerland
Systems Biology of Virus-Host Interaction
Short Talk(s) Chosen from Abstracts
Workshop 1
Short Talks Chosen from Abstracts
Entry and Assembly
Sara R. Cherry, University of Pennsylvania School of Medicine, USA
Alphavirus Entry
William M. Gelbart, University of California, Los Angeles, USA
Assembly of Bromo and Alpha Viruses and their Hybrids
Glenn C. Randall, University of Chicago, USA
Mechanisms of Hepatitis C Virus Assembly and Egress
Short Talk Chosen from Abstracts
WEDNESDAY, MAY 1
Adaptive Immunity and Vaccines
Kim Y. Green, NIAID, National Institutes of Health, USA
Norovirus Pathogenesis and Vaccines
Robert Thimme, University Medical Center Freiburg, Germany
Failure of Adaptive Immunity to Clear HCV Infection
Christian W. Mandl, Novartis Vaccines and Diagnostics, Inc, USA
Alphavirus-Vectored Vaccines
Diane E. Grifin, Johns Hopkins Bloomberg School of Public Health, USA
Alphavirus Encephalitis: Mechanisms of Virus Clearance
Short Talk(s) Chosen from Abstracts
RNA Structure and Function
Andrea Gamarnik, Fundacin Instituto Leloir, Argentina
Dynamics, Plasticity and Functions of the Dengue Virus Genome
Peter Sarnow, Stanford University School of Medicine, USA
MicroRNAs and their Role in Regulating HCV Replication
Ian Brierley, University of Cambridge, UK
Translational Gymnastics of RNA Viruses
Short Talk(s) Chosen from Abstracts
THURSDAY, MAY 2
Replication Enzymes and their Inhibition
Bruno Canard, AFMB ESIL Case 925, France
The Interplay of RNA Synthesis, Fidelity and RNA Capping in Coronaviruses
Eric J. Snijder, Leiden University Medical Center, Netherlands
The Versatility of Arterivirus NSP2
Nuria Verdaguer, Institut de Biologia Molecular de Barcelona
(CSIC), Spain
FMDV RdRp: Structure and Fidelity
John O. Link, Gilead Sciences, Inc, USA
Inhibitors of Hepatitis C Virus Replication: Viral and Host Cell Targets
Short Talk(s) Chosen from Abstracts
Workshop 2
Short Talks Chosen from Abstracts
Pathogenesis (Includes UPR, Stress Responses, Autophagy)
Beth Levine, University of Texas Southwestern Medical Center, USA
Selective Autophagy in Antiviral Immunity
Stanley M. Lemon, University of North Carolina at Chapel Hill, USA
Pathogenesis of HCV and HAV
Jari Valkonen, University of Helsinki, Finland
Plant RNA Virus-Host Interactions
Short Talk Chosen from Abstracts
FRIDAY, MAY 3: DEPARTURE
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
60
Scientic Organizers: Eric J. Snijder and Ralf Bartenschlager
THE INNATE IMMUNE RESPONSE
IN THE PATHOGENESIS OF INFECTIOUS DISEASE
MAY 1015, 2013
OURO PRETO, MINAS GERAIS, BRAZIL (venue information on page 53)
DEADLINES:
GLOBAL HEALTH TRAVEL AWARD DEC 11, 2012
ABSTRACT & SCHOLARSHIP JAN 7, 2013
LATE-BREAKING ABSTRACT FEB 4, 2013
DISCOUNTED REGISTRATION MAR 5, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster session, plenary session
or workshop.
WWW.KEYSTONESYMPOSIA.ORG/13E1
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13E1.
FRIDAY, MAY 10: ARRIVAL & REGISTRATION
Keynote Session
Rodrigo Corra-Oliveira*, FIOCRUZ Minas, Brazil
Keystone Brazil and the Challenges of Global Tropical Diseases
Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
Innate Immune Pathways in Drosophila
Jean-Laurent Casanova, Rockefeller University, USA
Toward a Genetic Theory of Infectious Diseases
SATURDAY, MAY 11
Innate Immune Recognition
Caetano Reis e Sousa, Cancer Research UK London Research
Institute, UK
Myeloid C-Type Lectin Receptors in Pathogen Recognition and Host Defense
Vishva M. Dixit, Genentech, Inc., USA
Inlammasome Activation
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Immune Surveillance from the Cytosol
Julie Magarian Blander, Mount Sinai School of Medicine, USA
Detecting and Responding to Microbial Viability
Short Talk(s) Chosen from Abstracts
Workshop 1: Innate Recognition and Microbial Pathogenesis
Short Talks Chosen from Abstracts
Innate Immunity in Vectors
Elena A. Levashina*, Max Planck Institute for Infection
Biology, Germany
Mechanisms of Innate Resistance to Malaria Parasites in the Mosquito
George Dimopoulos, Johns Hopkins University, USA
Innate and Microbiota-Mediated Control of Dengue Virus in Mosquitoes
David L. Sacks, NIAID, National Institutes of Health, USA
Inluence of Vector Transmission on the Innate Immune Response
to Leishmania major
Short Talk Chosen from Abstracts
SUNDAY, MAY 12
Innate Lymphoid Cells (ILC) and Mucosal Immunity
Fiona M. Powrie*, University of Oxford NDM, UK
Innate Regulation of Intestinal Mucosal Inlammation
David Artis, University of Pennsylvania, School of Medicine, USA
ILC in Regulation of Mucosal Immune Responses
Dan R. Littman, New York University School of Medicine, USA
Immune Homeostasis and Host Protection by Commensal Bacteria
Marco Colonna, Washington University School of Medicine, USA
NK Cells in Innate Immune Responses in Mucosal Sites
Short Talk(s) Chosen from Abstracts
Workshop 2: Cytokine, Inlammation and Pathogenesis
Short Talks Chosen from Abstracts
Effector Mechanisms
Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany
DNA Nets, a Potent Anti-Microbial Effector Function of Neutrophils
Speaker to be Announced
Jonathan Howard, University of Cologne, Germany
IFN--Inducible GTPases in Control of Intracellular Parasites
Short Talk Chosen from Abstracts
MONDAY, MAY 13
Innate Cytokines Inluencing Adaptive Immunity
and Inlammation
Richard M. Locksley*, University of California, San Francisco, USA
Innate Determinants of Th2 Responses
Alan Sher, NIAID, National Institutes of Health, USA
Innate Regulation of Th1 Responses
Kingston H. G. Mills, Trinity College Dublin, Ireland
Innate Determinants of Th17 Responses
Edgar M. Carvalho, Universidade Federal da Bahia, Brazil
Innate Determinants of T Lymphocyte Responses in Human Leishmaniasis
Short Talk(s) Chosen from Abstracts
Workshop 3: Cell Death and Pathogenesis
Short Talks Chosen from Abstracts
Innate Signals in Disease Pathogenesis
Speaker to be Announced
Douglas Golenbock, University of Massachusetts Medical School, USA
DNA Sensing Drives the Innate Immune Response in Malaria
Anne OGarra*, MRC National Institute for Medical Research, UK
Cytokines and Pathogenesis in TB
Short Talk Chosen from Abstracts
TUESDAY, MAY 14
Cell Death in Host Resistance and Pathogenesis
of Infectious Diseases
Douglas R. Green, St. Jude Childrens Research Hospital, USA
Pathogen-Induced Necrosis
Ricardo T. Gazzineli CPQRRFiociuz Biazil
Pyroptosis in Malaria
Speaker to be Announced
Maya Saleh, McGill University, Canada
Role of Caspases in the Regulation of Inlammation and Immunity
Short Talk(s) Chosen from Abstracts
Immunological Adjuvants and Vaccines
Jorge Kalil*, Universidade de So Paolo, Brazil
Dengue Vaccine Candidates
Robert L. Coffman, Dynavax Technologies, USA
Clinical Applications of Innate Immune Signals
Bali Pulendran, Emory University, USA
Long-Term Immune Responses Induced by Adjuvants
Closing Keynote Address
Michel C. Nussenzweig, Rockefeller University, USA
Targeting Dendritic Cells in Malaria Vaccine
WEDNESDAY, MAY 15: DEPARTURE

*Session Chair
This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during one
of these poster sessions, or a plenary session or workshop.
61
Scientic Organizers: Ricardo T. Gazzineli,
Gustavo P. Amarante-Mendes, Anne OGarra and Alan Sher
Organized as an international collaboration and with generous support from CNPq
the National Council for Scientic and Technological Development, Brazil, and FAPEMIG Minas Gerais State Agency for Research
Development. Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill & Melinda Gates Foundation.
THE HIPPO TUMOR SUPPRESSOR NETWORK:
FROM ORGAN SIZE CONTROL TO STEM CELLS
AND CANCER
MAY 1923, 2013
HYATT REGENCY MONTEREY, MONTEREY, CALIFORNIA, USA
(venue information on page 53)
DEADLINES:
ABSTRACT & SCHOLARSHIP JAN 17, 2013
LATE-BREAKING ABSTRACT FEB 18, 2013
DISCOUNTED REGISTRATION MAR 19, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13E2
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13E2.
Scientic Organizers: Marius Sudol, Helen McNeill, Georg A. Halder and Giovanni Blandino
SUNDAY, MAY 19: ARRIVAL & REGISTRATION
MONDAY, MAY 20
Keynote Address
Joseph Avruch, Massachusetts General Hospital, USA
How Does the Core Kinase Cassette of the Hippo Pathway Control
the Yki, YAP and TAZ Effectors?
Membrane and Upstream Signals
Helen McNeill, Samuel Lunenfeld Research Institute, Canada
Signals from FAT Receptors in Flies and in Mammals
Fernando D. Camargo, Childrens Hospital Boston, USA
Hippo Pathway Models in Mice: Stem Cells, Diseases and Emerging
Strategies for Therapies
Xaralabos Varelas, Boston University, USA
Cross-Talk between Hippo, TGF- and Wnt Signaling Pathways
Short Talk(s) Chosen from Abstracts
Hippo in Flies and Mammals: Orthology and Diversity
Duojia (DJ) Pan, Johns Hopkins University School of Medicine, USA
Crumbs and Merlin Signaling in Flies and Mammals
Nicolas Tapon, Cancer Research UK London Research Institute, UK
New Approaches to Deine the Extended Network of the Hippo Pathway
in Drosophila Fly Implications for the Mammalian Pathway
Joan S. Brugge, Harvard Medical School, USA
The Role of YAP Oncogene in Cytokinesis
Short Talk Chosen from Abstracts
TUESDAY, MAY 21
Junctional Complexes and the Hippo Pathway
Joseph L. Kissil, Wistar Institute, USA
Angiomotins, Merlin and Tumor Suppression Mechanisms in Mice
and Men
Wan Jin Hong, Institute of Molecular and Cell Biology, Singapore
Angiomotins Use YAP/TAZ as a Shuttle between Junctional Complexes
and Nuclear Signaling
Georg A. Halder, University of Texas MD Anderson Cancer
Center, USA
Regulation of the Hippo Pathway by Cell Polarity and Mechanical Forces
Hiroshi Sasaki, Kumamoto University, Institute of Molecular
Embryology and Genetics, Japan
The Role of YAP and Hippo Pathway in Early Mouse Development
Short Talk(s) Chosen from Abstracts
Hippo Network in Organ Size Control
Junichi Sadoshima, University of Medicine and Dentistry
of New Jersey, USA
Hippo-Lats and YAP in Heart Development
Laura Johnston, Columbia University, USA
Organ Size Homeostasis Regulated by Myc and Yki
Muhammad Al-Hajj, GlaxoSmithKline, USA
Hippo Pathway in Cancer Drug Discovery
Short Talk Chosen from Abstracts
WEDNESDAY, MAY 22
Deregulation of Hippo Pathway in Cancer
Kieran Harvey, Peter MacCallum Cancer Centre, Australia
The Hippo Pathway, Tissue Growth and Cancer
Yael Aylon, Weizmann Institute of Science, Israel
Cooperation between ASPP1 and LATS2 in Tumor Suppression
Giovanni Blandino, Regina Elena Cancer Institute, Italy
Mechanisms by which cis-platin Treatment of Tumors Affects Hippo
Pathway Signaling
Stefano Piccolo, University of Padua, Italy
Regulation of YAP and TAZ by Tissue Architecture
Short Talk(s) Chosen from Abstracts
From Structure-Function Analysis to Details
of the Mechanisms that Govern Hippo Signaling
Tony Pawson, Samuel Lunenfeld Research Institute, Canada
Regulation of Rho GTPases and Kinases in Hippo Signaling
Kun-Liang Guan, University of California, San Diego, USA
YAP/TAZ-TEAD Complex and Transcriptional Program of Proliferation
Marius Sudol, Weis Center for Research, USA
Hippo Pathway as the WW Domain-Mediated Network of Signals
THURSDAY, MAY 23: DEPARTURE

This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
62
HUMAN GENOMICS
AND PERSONALIZED MEDICINE
JUNE 1721, 2013
CLARION HOTEL SIGN, STOCKHOLM, SWEDEN
(venue information on page 53)
DEADLINES:
ABSTRACT & SCHOLARSHIP FEB 20, 2013
LATE-BREAKING ABSTRACT MAR 19, 2013
DISCOUNTED REGISTRATION APR 16, 2013
Submit your abstract for the opportunity to be selected
as a presenter during a poster or plenary session.
WWW.KEYSTONESYMPOSIA.ORG/13E3
Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13E3.
Scientic Organizers: Kelly A. Frazer and Geoffrey S. Ginsburg
Organized in collaboration with Knut and Alice Wallenberg Foundation and Science for Life Laboratory Stockholm
Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc. and Onyx Pharmaceuticals, Inc.
MONDAY, JUNE 17: ARRIVAL & REGISTRATION
Keynote Address
John Bell, University of Oxford, UK
Breakthroughs in Genomic and Personalized Medicine
Peter Mueller, Vertex Pharmaceuticals Incorporated, USA
Target Therapy for Cystic Fibrosis: From Gene to Patient
Geoffrey S. Ginsburg, Duke University, USA
Novel Host-Based Approaches to the Diagnosis of Infectious Disease
Speaker to be Announced
Late-Breaking Findings
TUESDAY, JUNE 18
Genomes and Biology
Richard P. Lifton

, HHMI/Yale University School of Medicine, USA


Talk Title to be Determined
Kelly A. Frazer, University of California, San Diego, USA
The Role of Regulatory Variants in Disease
Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA
The Epigenetic Basis of Common Human Disease
Speaker to be Announced
Cancer Genomics and Applications
Paul S. Mischel, University of California, Los Angeles, USA
The Cancer Genome Atlas and the Future of Cancer Diagnosis
and Treatment
Steven Shak, Genomic Health Inc., USA
Translating Genomics into Clinical Practice: Lessons from Oncotype DX
Thomas J. Hudson, Ontario Institute for Cancer Research, Canada
Linking Cancer Treatment Decisions with Large-Scale Mutation Surveys
Hiroyuki Mano, University of Tokyo/Jichi Medical University, Japan
Targeted Therapies in Cancer
WEDNESDAY, JUNE 19
Advances and Challenges in the Field
Janet Woodcock, US Food and Drug Administration, USA
A Regulatory Pathway to Personalized Medicine
Jill Mesirov, Broad Institute, USA
The Complexity of Complex Data
Dan M. Roden, Vanderbilt University School of Medicine, USA
Integration and Implementation of Genetic Information
into Health Systems
Howard J. Jacob, Medical College of Wisconsin, USA
Advances in Clinical Sequencing
Pharmacogenomics
Alan R. Shuldiner, University of Maryland School of Medicine, USA
Genomic Management of Anti-Platelet Therapeutics
Howard McLeod, University of North Carolina at Chapel Hill, USA
Pharmacogenetics of Cancer Therapeutics
Keith J. Johnson, Novartis Institutes for BioMedical Research, Inc., USA
Innovations in Pharmacogenomics-Enabled Drug Development
Y.T. Chen, Duke University, USA
Realizing the Promise of Personalized Medicine: HLA-B*1502
Screen in Preventing Carbamazepine-Induced Toxic Effects
WEDNESDAY, JUNE 19 CONTINUED
Personalized Genomes
Michael Snyder, Stanford University School of Medicine, USA
Adventures in Personal Genomics: iPOP of Healthy and Disease States
William A. Gahl, NHGRI, National Institutes of Health, USA
Whole Exome Sequencing for Undiagnosed Diseases
George M. Church, Harvard Medical School, USA
The Personal Genome Project and the Future of Medicine
THURSDAY, JUNE 20
Policy
Susanne B. Haga, Duke University, USA
Introducing Genomics in the Clinic: Development of New Delivery Systems
Laura Lyman Rodriguez, NHGRI, National Institutes of Health, USA
Bringing Genomics into Medicine: Advancing the Policy Agenda
Katherine Payne, University of Manchester, UK
Quantifying the Economic Value of Personalized Medicine
Jane Kaye, University of Oxford, UK
Privacy, Data-Sharing Frameworks, Global Governance
and Translational Research
Translating Biomarkers to Personalized Medicine
Michelle Penny, Eli Lilly and Company, USA
Integration of Genomic Technologies into Drug Discovery and Development
Jonathan K.C. Knowles, cole Polytechnique Fdrale de Lausanne
(EPFL), Switzerland
Developing Diagnostics from Biomarkers
Thomas Metcalfe, Oncotest GmbH Institute for Experimental
Oncology, Germany
Co-Development of Therapeutics and Companion Diagnostics
FRIDAY, JUNE 21: DEPARTURE

Invited, not yet accepted


This conference will also feature poster sessions, providing excellent
opportunities to network and discuss your research. Submit your abstract
online by the deadlines listed above for the chance to present during a
poster or plenary session.
63
CHAMPIONS Highest-tier donors, contributing $100,000+ annually
Bill & Melinda Gates Foundation
Merck & Co., Inc.
Minas Gerais State Agency for Research Development (FAPEMIG) Brazil
National Institute of Diabetes and Digestive and Kidney Diseases, NIH
National Council foi Scientiic anu Technological
Development (CNPq) Brazil
SUSTAINING BENEFACTORS Donors making a three-year or ongoing commitment of $50,000$99,999 per year
Bayer USA Foundation
Takeda Pharmaceutical Company Limited
BENEFACTORS Donating $50,000$99,999
Educational donation provided by Amgen
Genentech, Inc.
National Multiple Sclerosis Society
SUSTAINING SPONSORS Donors making a three-year commitment of $25,000$49,999 per year
Abbott Laboratories
Astellas Pharma Inc.
Biogen Idec
Boehringer Ingelheim Pharmaceuticals, Inc.
Celgene Corporation
Gilead Sciences, Inc.
Hoffmann-La Roche Inc.
SPONSORS Contributing $25,000$49,999
AstraZeneca Pharmaceuticals, L.P.
Bristol-Myers Squibb
GlaxoSmithKline
Isis Pharmaceuticals, Inc.
Janssen Pharmaceuticals, Inc.
Educational grant from Lilly USA, LLC
PARTNERS ($10,000$24,999)
Cell Signaling Technology, Inc.
The Ellison Medical Foundation
PATRONS ($5,000$9,999)
AdipoGen International
Avanti Polar Lipids
CEDARLANE Laboratories
DONORS ($2,500$4,999)
Agilent Technologies
American Heart Association's Council on Cardiopulmonary,
Critical Care, Perioperative and Resuscitation
BioVentures, Inc.
Bruker Biospin Corp.
ChemoCentryx, Inc.
Chroma Technology Corporation
Cubist Pharmaceuticals, Inc.
Essential Pharmaceuticals, LLC
CONTRIBUTORS (up to $2,499)
American Heart Association's Council
on Cardiovascular Disease in the Young
Echelon Biosciences Incorporated
64
THANK YOU FOR YOUR SUPPORT OF THE 20122013 CONFERENCE SERIES
National Institute of General Medical Sciences, NIH
Minority Access to Research Careers (MARC)
Novartis Institutes for BioMedical Research
0fice of AIBS Reseaich NIB
Science for Life Laboratory Stockholm
Knut and Alice Wallenberg Foundation
Nestl Institute of Health Sciences
Novo Nordisk A/S
Pizei Inc
Ininity Phaimaceuticals
MedImmune
Onyx Pharmaceuticals, Inc.
Regulus Therapeutics Inc.
Sangamo BioSciences, Inc.
Vertex Pharmaceuticals Incorporated
Medicines for Malaria Venture Ian Bathurst Global Health
Travel Awards
Monsanto Company
Novartis Pharma K.K.
Sanoi 0S
ISOTEC, a member of the Sigma-Aldrich Group
Opsona Therapeutics Ltd
Promega Corporation
The Rockefeller University Press
The Journal of Experimental Medicine
Sigma Life Science
STEMCELL Technologies
Syngenta Biotechnology, Inc.
Novus Biologicals
Seahorse Bioscience, Inc.
New Era Enterprises, Inc.
Rigaku Americas Corporation
Landes Bioscience
THANK YOU FOR YOUR SUPPORT OF THE 20122013 CONFERENCE SERIES
DIRECTORS FUND SPONSORS Donors with unrestricted gifts of at least $25,000. These generous gifts allow our Directors to schedule
meetings in a wide variety of important areas, many of which are in the early stages of research.
Abbott Laboratories
Educational donation provided by Amgen
Astellas Pharma Inc.
Bayer USA Foundation
Biogen Idec
Boehringer Ingelheim Pharmaceuticals, Inc.
Bristol-Myers Squibb
Celgene Corporation
Genentech, Inc.
Gilead Sciences, Inc.
GlaxoSmithKline
Hoffmann-La Roche Inc.
Ininity Phaimaceuticals
Isis Pharmaceuticals, Inc.
Janssen Pharmaceuticals, Inc.
DIRECTORS FUND Gifts made to the Directors Fund are used at the discretion of Keystone Symposias President/CEO and Directors.
We gratefully acknowledge the following donors, whose gifts allow Keystone Symposia to subsidize a wide variety of meetings and provide scholarships
to talented graduate students and postdoctoral fellows.
AdipoGen International
Agilent Technologies
Avanti Polar Lipids
BioVentures, Inc.
Bruker Biospin Corp.
CEDARLANE Laboratories
ChemoCentryx, Inc.
Chroma Technology Corporation
Cubist Pharmaceuticals, Inc.
Echelon Biosciences Incorporated
Essential Pharmaceuticals, LLC
ISOTEC, a member of the Sigma-Aldrich Group
KEYSTONE SYMPOSIA FUTURE OF SCIENCE FUND Gifts from individuals provide funding for general and underrepresented
minority scholarships and travel awards for investigators from countries most affected by topics of specic meetings. Funds can also be designated to
support general meeting program expenses, as well as program costs for specic meetings of choice. The donors below gave during the 12 months ending
June 18, 2012.
PRESIDENTS CIRCLE ($10,000+)
The Elkes Foundation
FOUNDERS SOCIETY ($5,000$9,999)
A.J. Miller
KEYSTONE CHAMPIONS ($1,000$4,999)
Jim & Sue Aiken
Christopher Atwood
Kenneth W. Bair
Edward A. Dennis
Margaret Liu, Robert Johnson
Masaru Okabe
Anthony Pawson
Alessanuio Pocai Naico anu Soia Pocai
with matching gift from Merck Partnership for Giving
Roy G. Michell Charitable Foundation and Trust
Sidney E. Frank Foundation
Craig B. Thompson
David and Marcy Woodland
Juleen Zierath
Anonymous (3)
Please visit www.keystonesymposia.org for a list of our Future
of Science Fund donors at the Patron and Contributor levels and to
learn more about becoming a donor in support of our mission.
KEYSTONE BENEFACTORS ($500$999)
Raymond N. DuBois
Joseph Heitman
Laura L. Kiessling, Ronald T. Raines
Michinori Kohara
Suraj P. Manrao
Terry J. Opgenorth
Andrew D. Robertson
Kazuo Tsubota
Sally Wenzel
Ian Wilson
Masayuki Yamamoto
Anonymous (3)
65
Educational grant from Lilly USA, LLC
MedImmune
Merck & Co., Inc.
Monsanto Company
Novartis Institutes for BioMedical Research
Novo Nordisk A/S
Onyx Pharmaceuticals, Inc.
Pizei Inc
Regulus Therapeutics Inc.
Sangamo BioSciences, Inc.
Sanoi 0S
Takeda Pharmaceutical Company Limited
Vertex Pharmaceuticals Incorporated
Landes Bioscience
Novus Biologicals
Opsona Therapeutics Ltd
Promega Corporation
Rigaku Americas Corporation
The Rockefeller University Press The Journal
of Experimental Medicine
Seahorse Bioscience, Inc.
Sigma Life Science
STEMCELL Technologies
Syngenta Biotechnology, Inc.
KEYSTONE SYMPOSIA BOARD AND STAFF (as of June 18, 2012)
BOARD OF DIRECTORS
Juleen R. Zierath, Ph.D.
Chair of the Board, Keystone Symposia
Professor, Molecular Medicine and Surgery
Karolinska Institutet
Craig B. Thompson, M.D.
Secretary of the Board
Chair, Scientiic Advisory Board
Keystone Symposia
Piesiuent anu Chief Executive 0ficei
Memorial Sloan-Kettering Cancer Center
Terry J. Opgenorth, Ph.D.
Treasurer of the Board
Chair, Finance Committee, Keystone Symposia
Vice President
CSU Ventures
James W. Aiken, Ph.D.
Piesiuent anu Chief Executive 0ficei
Keystone Symposia on Molecular
and Cellular Biology
Kenneth W. Bair, Ph.D.
Chair, Audit Committee, Keystone Symposia
Senior Vice President and Head
Reseaich anuBevelopment
Forma Therapeutics, Inc.
Beverly M. Emerson, Ph.D.
Chair, Personnel Committee
Keystone Symposia
Professor, Regulatory Biology Laboratory
The Salk Institute
Peter M. Finan, Ph.D.
Associate Disease Area Head
Respiratory Diseases
Novartis Institutes for BioMedical Research
Heidi E. Hamm, Ph.D.
Professor and Chair
Department of Pharmacology
Vanderbilt University School of Medicine
Edison T. Liu, M.D.
Piesiuent anu Chief Executive 0ficei
The Jackson Laboratory
Margaret A. Liu, M.D.
Chair, Development Committee
Keystone Symposia
ProTherImmune
Visiting Professor, Karolinska Institutet
Gary J. Nabel, M.D., Ph.D.
Bethesda, Maryland
Tony Pawson, Ph.D.
Senior Investigator
Centre for Systems Biology
Samuel Lunenfeld Research Institute
Mount Sinai Hospital, Toronto
Alan Sher, Ph.D.
Chair, Nominating Committee
Keystone Symposia
Bethesda, Maryland
Ian A. Wilson, Ph.D., Sc.D., FRS
Professor
Department of Molecular Biology and
The Skaggs Institute for Chemical Biology
The Scripps Research Institute
EMERITUS BOARD MEMBERS:
Ralph A. Bradshaw, Ph.D.
Professor Emeritus, Physiology and
Biophysics
College of Medicine
University of California, Irvine
Professor in Pharmaceutical Chemistry
and Deputy Director of Mass
Spectrometry Facility
University of California, San Francisco
Robert W. Craig
President Emeritus, The Keystone Center
Edward A. Dennis, Ph.D.
Professor, Chemistry, Biochemistry
and Pharmacology
School of Medicine
0niveisity of CalifoiniaSan Biego
Curtis C. Harris, M.D.
Chief, Laboratory of Human Carcinogenesis
NCI, National Institutes of Health
All Board and Emeritus Board Members are
also members of Keystone Symposias Scientiic
Advisory Board.
KEYSTONE SYMPOSIA STAFF
James Aiken, Chief Executive Oficer
Pamela Daugherty, Chief Financial Oficer
David Woodland, Chief Scientiic Oficer
Jeannie Dalrymple, Senior Director, Program Development
& Implementation
Linda Hrycaj, Senior Director, Strategic Planning
Christopher Atwood, Director, Development
Heidi Daetwyler-Simpson, Director, Meeting Management
Laina King, Director, Diversity in Life Science Programs
Tanya Muller, Director, Information Technology
Yvonne Psaila, Director, Marketing &Communications
Mary Jo Roal, Director, Human Resources
David Adamson, On-Site Staff Representative
Arne Ahlstrom, On-Site Staff Representative
Cathy Banks, Web Developer/Systems Analyst
Carol Bosserman, On-Site Staff Representative
Mary Brown, On-Site Staff Representative
Caroline Brendel, Executive Administrative Assistant
Melissa Carrera, Assistant Director of Development
Linda Cooper, Publications Assistant
Amanda Deem, Assistant Director of Development
Heather Gerhart, Senior Grant Coordinator & Program Analyst
Susan Gunn, Seasonal Logistics Representative
Lindsey Heilmann, Conference Coordinator
Jenny Hindorff, Program Implementation Associate
Kellan Hoover, Marketing Associate
Mike Lachata, Information TechnologyProgrammer
Sarah Lavicka, Administrative & Research Assistant, Development
Jeff Lehman, Scholarship Coordinator
Phyllis McNeil, Attendee Services Specialist
Allison Ogdon, Program Development Coordinator
Annie Page, On-Site Staff Representative
McKennzie Rains, IT Support/Assistant
Grace Roath, Ofice Manager
Julie Roll, On-Site Staff Representative
David Sanchez, Manager, Attendee Services
Barbara Schmid-Miller, Program Implementation Assistant
Gwyn Schmude, Attendee Services Specialist
Dawn Shafer, Accounting Clerk
Bridget Stacy, Administrative Assistant, Diversity
Kathy Tavares, Program Implementation Supervisor
Rebecca Wilkerson, Finance Assistant
66
E. Dale Abel, M.D., Ph.D.
Professor of Medicine, Biochemistry
and Human Genetics
Chief, Division of Endocrinology
Metabolism and Diabetes
Investigator, Program in Molecular Medicine
Josie I. Johnson Professorship in Molecular Biology
Medicine and Biochemistry
The University of Utah School of Medicine
Jacques F. Banchereau, Ph.D.
Senioi vice Piesiuent anu Chief Scientiic 0ficei
Inlammation anu viiology
Hoffmann-La Roche Inc.
Stephen L. Brenner, Ph.D.
Vice President of Molecular Biosciences
Bristol-Myers Squibb Company
Leslie J. Browne, Ph.D.
Piesiuent anu CE0
Senesco Technologies, Inc.
Thomas F. Bumol, Ph.D.
Vice President, BioTechnology Research
Lilly Research Laboratories
President and Site Head
Applied Molecular Evolution, Inc.
and Lilly Biotechnology Center San Diego
Judith Campisi, Ph.D.
Professor
Buck Institute for Research on Aging
Arturo Casadevall, M.D.
Professor and Chair
Microbiology and Immunology
Albert Einstein College of Medicine
Hubert C. Chen, M.D.
Vice President, Translational Medicine
Regulus Therapeutics Inc.
Robert L. Coffman, Ph.D.
vice Piesiuent anu Chief Scientiic 0ficei
Dynavax Technologies
Max D. Cooper, M.D.
Georgia Research Alliance Eminent Scholar
Professor of Pathology and Laboratory Medicine
Emory University School of Medicine
Alan J. Cross, Ph.D.
Chief Scientist, CNS and Pain Innovative Medicines
AstraZeneca Pharmaceuticals
Manoj C. Desai, Ph.D.
Vice President, Medicinal Chemistry
Gilead Sciences, Inc.
Vishva M. Dixit, M.D.
Vice President, Research
Physiological Chemistry
Genentech, Inc.
Robert H. Eckel, M.D.
Charles A. Boettcher Endowed Chair in Atherosclerosis
Professor of Medicine and of Physiology and Biophysics
Program Director, Adult GCRC
Medicine/Endocrinology
University of Colorado Denver
Anschutz Medical Campus
Martin P. Edwards, Ph.D.
Vice President, Cancer Chemistry
Pizei La }olla
Lee M. Ellis, M.D.
Professor
Cancei Biology anu Suigical 0ncology
The University of Texas MD Anderson
Cancer Center
I. Sadaf Farooqi, Ph.D., FRCP
Wellcome Trust Senior Clinical Fellow
and Reader in Human Metabolism
Metabolic Research Laboratories
University of Cambridge
Curt R. Freed, M.D.
Professor and Head
Division of Clinical Pharmacology and Toxicology
University of Colorado Denver School of Medicine
Adolfo Garcia-Sastre, Ph.D.
Professor, Department of Microbiology
Co-Director, Emerging Pathogens Institute
Mount Sinai School of Medicine
Tariq Ghayur, Ph.D.
Research Fellow
Abbott Bioresearch Center
Margaret Peggy A. Goodell, Ph.D.
Piofessoi Peuiatiics Bematology0ncology
Director, Star Center
Center for Cell and Gene Therapy
Baylor College of Medicine
Douglas R. Green, Ph.D.
Doherty Chair of Immunology
Department of Immunology
St. Jude Childrens Research Hospital
Philip D. Gregory, Ph.D.
Chief Scientiic 0ficei Reseaich
Sangamo Biosciences, Inc.
Diane E. Grifin, M.D., Ph.D.
Professor and Chair
Molecular Microbiology and Immunology
Johns Hopkins Bloomberg School of Public Health
Jacqueline E. Heard, Ph.D.
Venture Capital Principal
Global Strategy and R&D Investment
Monsanto Company
Kim A. Heidenreich, Ph.D.
Professor, Department of Pharmacology
University of Colorado Denver (UCHSC)
Christopher L. Karp, MD
Deputy Director
Vaccines & Host-Pathogen Biology
Global Health Discovery & Translational Sciences
Bill & Melinda Gates Foundation
Elliott D. Kieff, M.D., Ph.D.
Albee Professor
Medicine, Microbiology and Molecular Genetics
Harvard University
Laura L. Kiessling, Ph.D.
Hilldale Professor of Chemistry
Laurens Anderson Professor of Biochemistry
Department of Chemistry and Biochemistry
University of Wisconsin-Madison
Jacqueline Kirchner, Ph.D.
Scientiic Biiectoi Inlammation
Amgen Inc.
Christopher Kirk, Ph.D.
Vice President, Research
0nyx Phaimaceuticals Inc
Jan E. Leach, Ph.D.
University Distinguished Professor
Bioagricultural Sciences
Colorado State University
Karolin Luger, Ph.D.
HHMI Investigator and Professor
Department of Molecular Biology and Biochemistry
Colorado State University
Lamine MBow, Ph.D.
Director
Immunology anu Inlammation
Boehringer Ingelheim
Elizabeth M. McNally, M.D., Ph.D.
Professor
Department of Medicine and Human Genetics
University of Chicago
Juanita L. Merchant, M.D., Ph.D.
Departments of Internal Medicine
and Molecular and Integrative Physiology
University of Michigan
Tara Mirzadegan, Ph.D.
Team Leader, Computational Chemistry
Johnson & Johnson Pharmaceutical
Research & Development, L.L.C.
Hiroyuki Odaka, Ph.D.
General Manager, Pharmaceutical Research Division
Takeda Pharmaceutical Company Limited
Anne OGarra, Ph.D., FRS, FMedSci
Head, Division of Immunoregulation
MRC National Institute for Medical Research
Vito J. Palombella, Ph.D.
Chief Scientiic 0ficei
Ininity Phaimaceuticals Inc
Eric M. Parker, Ph.D.
Senior Director and Neuroscience Site Lead
Neuioscience anu 0phthalmology
Merck Research Laboratories
Catherine E. Peishoff, Ph.D.
Vice President
Computational and Structural Chemistry
GlaxoSmithKline Pharmaceuticals
Ronald T. Raines, Ph.D.
Professor, Departments of Biochemistry and Chemistry
University of WisconsinMadison
Greg Reyes, M.D., Ph.D.
Senior Vice President
Drug Discovery
Celgene Corporation
Roger R. Reddel, Ph.D.
Director
Childrens Medical Research Institute, Sydney
Juan Rivera, Ph.D.
Deputy Director, Intramural Research Program
Chief, Laboratory of Molecular Immunogenetics
and Molecular Immunology Section
NIAMS, National Institutes of Health
Cristina M. Rondinone, Ph.D.
Vice President, Research & Development
Head, Cardiovascular & Metabolic Diseases
MedImmune
Nadia A. Rosenthal, Ph.D.
Director of EMBL Monterotondo
Mouse Biology Unit
European Molecular Biology Laboratory
Andrej Sali, Ph.D.
Professor, Bioengineering and Therapeutic Sciences
University of California, San Francisco
Martin Schneider, Ph.D.
Senior Vice President, Global Therapeutical Research
Professor, Global Drug Discovery
Bayer HealthCare AG
Stephen J. Simpson, Ph.D.
Life Sciences Directorate
Science Foundation Ireland
Frank J. Slack, Ph.D.
Professor, Molecular, Cellular
and Developmental Biology
Yale University
Didier Y.R. Stainier, Ph.D.
Professor, Department of Biochemistry and Biophysics
School of Medicine
University of California, San Francisco
Eric E. Swayze, Ph.D.
Vice President, Medicinal Chemistry
Isis Pharmaceuticals, Inc.
Doris A. Taylor, Ph.D.
Director
Regenerative Medicine Research
Texas Heart Institute
Thomas Tuschl, Ph.D.
HHMI Investigator and Associate Professor
Laboratory of RNA Molecular Biology
The Rockefeller Institute
Joanne Jo L. Viney, Ph.D.
Vice President, Immunology Research
Biogen Idec
Nicolai R. Wagtmann, Ph.D.
vice Piesiuent anu Beau of Inlammation
Biology
Biopharmaceuticals Research Unit
Novo Nordisk A/S
Michael J.O. Wakelam, Ph.D.
Institute Director
The Babraham Institute
Andrew Ward, Ph.D.
Assistant Professor
Molecular Biology
The Scripps Research Institute
David R. Webb, Ph.D.
Adjunct Professor
Department of Molecular Biology
The Scripps Research Institute
Kenneth F. Wertman, Ph.D.
Scientiic Biiectoi Tucson
Associate Vice President
Discovery Research
Chemical and Analytical Sciences
Sanoi 0S
David L. Woodland, Ph.D.
Chief Scientiic 0ficei
Keystone Symposia on Molecular and Cellular Biology
KEYSTONE SYMPOSIA SCIENTIFIC ADVISORY BOARD (as of June 18, 2012)
67
KEYSTONE SYMPOSIA
20122013 Conference Series
www.keystonesymposia.org
Visit www.keystonesymposia.org/meetings or call 1.800.253.0685 or 1.970.262.1230 for the most current information and to register.
The 20122013 KeYSTONe SYMPOSIA CONfereNCe SerIeS AT A GlANCe
September 2012
Pulmonary Vascular Disease and Right Ventricular Dysfunction:
Current Concepts and Future Therapies (S1), Monterey, CA, USA #KSPVD
October 2012
Aging and Diseases of Aging (S2), Tokyo, Japan #KSaging
December 2012
Immunological Mechanisms of Vaccination (S3), Ottawa, ON, Canada
#KSvaccine
January 2013
Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1)
joint with Pathogenic Processes in Asthma and COPD (J2), Santa fe, NM, USA
#KSimmunity / #KSlung
Multiple Sclerosis (A1), Big Sky, MT, USA #KSMS
New Frontiers in Cardiovascular Genetics Beyond GWAS (A2), Tahoe City, CA,
USA #KScardio
Frontiers of NMR in Biology (A3), Snowbird, Utah, USA #KSNMr
Hematopoiesis (A4), Steamboat Springs, CO, USA #KShema
Emerging Topics in Immune System Plasticity: Cellular Networks, Metabolic
Control and Regeneration (A5), Santa fe, NM, USA #KSimmunity
Plant Abiotic Stress and Sustainable Agriculture: Translating Basic
Understanding to Food Production (A6), Taos, NM, USA #KSplant
Noncoding RNAs in Development and Cancer (A7), Vancouver, BC, Canada
#KSncrNA
Malaria (A8), New Orleans, lA, USA #KSmalaria
Metabolic Control of Infammation and Immunity (A9), Breckenridge, CO,
USA #KSimmunity
Antibodies as Drugs (J3) joint with Cancer Immunology and Immunotherapy
(J4), Vancouver, BC, Canada #KSdrug / #KScancer
Adipose Tissue Biology (J5) joint with Diabetes New Insights into Mechanism
of Disease and its Treatment (J6), Keystone, CO, USA #KSadipose / #KSdiabetes
February 2013
Mitochondria, Metabolism and Myocardial Function Basic Advances
to Translational Studies (B1), Keystone, CO, USA #KSmitochondria
Neurogenesis (J7) joint with New Frontiers in Neurodegenerative Disease
Research (J8), Santa fe, NM, USA #KSneuro
Lung Development, Cancer and Disease (B2), Taos, NM, USA #KSlung
The Gut Microbiome: The Effector/Regulatory Immune Network (B3), Taos,
NM, USA #KSgut
B Cell Development and Function (X1) joint with HIV Vaccines (X2), Keystone,
CO, USA #KSbcell / #KShIV
Autophagy, Infammation and Immunity (B4), Montreal, QC, Canada
#KSautophagy
Nutrition, Epigenetics and Human Disease (B5), Santa fe, NM, USA #KSnutrition
Myeloid Cells: Regulation and Infammation (B6), Keystone, CO, USA
#KSmyeloid
February 2013 (continued)
Stem Cell Regulation in Homeostasis and Disease (B7), Banff, AB, Canada
#KSstemcell
PI 3-Kinase and Interplay with Other Signaling Pathways (X3) joint with
Tumor Metabolism (X4), Keystone, CO, USA #KSPI3K / #KScancer
March 2013
Structural Analysis of Supramolecular Assemblies by Hybrid Methods (C1),
Tahoe City, CA, USA #KSsupramolecular
Understanding Dendritic Cell Biology to Advance Disease Therapies (C2),
Keystone, CO, USA #KSdendritic
DNA Replication and Recombination (X5) joint with Genomic Instability
and DNA Repair (X6), Banff, AB, Canada #KSDNA
Growing to Extremes: Cell Biology and Pathology of Axons (C4), Tahoe City,
CA, USA #KSaxon
Host Response in Tuberculosis (X7) joint with Tuberculosis: Understanding
the Enemy (X8), Whistler, BC, Canada #KSTB
Precision Genome Engineering and Synthetic Biology: Designing Genomes
and Pathways (C5), Breckenridge, CO, USA #KSgenome
Neuronal Control of Appetite, Metabolism and Weight (C6), Banff, AB,
Canada #KSobesity
RNA Silencing (C7), Whistler, BC, Canada #KSrNA
Epigenetic Marks and Cancer Drugs (C8), Santa fe, NM, USA #KScancer
April 2013
Molecular Clockworks and the Regulation of Cardio-Metabolic Function (C9),
Snowbird, Utah, USA #KScardio
Immune Activation in HIV Infection: Basic Mechanisms and Clinical
Implications (D2), Breckenridge, CO, USA #KShIV
Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic
Dysfunction (D3), Alpbach, Austria #KSnuclear
Immunopathology of Type 1 Diabetes (Z1) joint with Advances in the
Knowledge and Treatment of Autoimmunity (Z2), Whistler, BC, Canada
#KSdiabetes / #KSautoimmunity
Cardiac Remodeling, Signaling, Matrix and Heart Function (D4), Snowbird,
UT, USA #KScardio
Plant Immunity: Pathways and Translation (D5), Big Sky, MT, USA #KSplant
Positive Strand RNA Viruses (D7), Boston, MA, USA #KSrNA
May 2013
The Innate Immune Response in the Pathogenesis of Infectious Disease (E1),
Ouro Preto, MG, Brazil #KSimmunity
The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells
and Cancer (E2), Monterey, CA, USA #KShippo
June 2013
Human Genomics and Personalized Medicine (E3), Stockholm, Sweden
#KSgenome
PO Box 1630
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Silverthorne, Colorado 80498 | USA
1.970.262.1230 | 1.800.253.0685 (US & Canada)
www.keystonesymposia.org/meetings
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