www.keystonesymposia.org Visit www.keystonesymposia.org/meetings or call 1.800.253.0685 or 1.970.262.1230 for the most current information and to register. The 20122013 KeYSTONe SYMPOSIA CONfereNCe SerIeS AT A GlANCe September 2012 Pulmonary Vascular Disease and Right Ventricular Dysfunction: Current Concepts and Future Therapies (S1), Monterey, CA, USA #KSPVD October 2012 Aging and Diseases of Aging (S2), Tokyo, Japan #KSaging December 2012 Immunological Mechanisms of Vaccination (S3), Ottawa, ON, Canada #KSvaccine January 2013 Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1) joint with Pathogenic Processes in Asthma and COPD (J2), Santa fe, NM, USA #KSimmunity / #KSlung Multiple Sclerosis (A1), Big Sky, MT, USA #KSMS New Frontiers in Cardiovascular Genetics Beyond GWAS (A2), Tahoe City, CA, USA #KScardio Frontiers of NMR in Biology (A3), Snowbird, Utah, USA #KSNMr Hematopoiesis (A4), Steamboat Springs, CO, USA #KShema Emerging Topics in Immune System Plasticity: Cellular Networks, Metabolic Control and Regeneration (A5), Santa fe, NM, USA #KSimmunity Plant Abiotic Stress and Sustainable Agriculture: Translating Basic Understanding to Food Production (A6), Taos, NM, USA #KSplant Noncoding RNAs in Development and Cancer (A7), Vancouver, BC, Canada #KSncrNA Malaria (A8), New Orleans, lA, USA #KSmalaria Metabolic Control of Infammation and Immunity (A9), Breckenridge, CO, USA #KSimmunity Antibodies as Drugs (J3) joint with Cancer Immunology and Immunotherapy (J4), Vancouver, BC, Canada #KSdrug / #KScancer Adipose Tissue Biology (J5) joint with Diabetes New Insights into Mechanism of Disease and its Treatment (J6), Keystone, CO, USA #KSadipose / #KSdiabetes February 2013 Mitochondria, Metabolism and Myocardial Function Basic Advances to Translational Studies (B1), Keystone, CO, USA #KSmitochondria Neurogenesis (J7) joint with New Frontiers in Neurodegenerative Disease Research (J8), Santa fe, NM, USA #KSneuro Lung Development, Cancer and Disease (B2), Taos, NM, USA #KSlung The Gut Microbiome: The Effector/Regulatory Immune Network (B3), Taos, NM, USA #KSgut B Cell Development and Function (X1) joint with HIV Vaccines (X2), Keystone, CO, USA #KSbcell / #KShIV Autophagy, Infammation and Immunity (B4), Montreal, QC, Canada #KSautophagy Nutrition, Epigenetics and Human Disease (B5), Santa fe, NM, USA #KSnutrition Myeloid Cells: Regulation and Infammation (B6), Keystone, CO, USA #KSmyeloid February 2013 (continued) Stem Cell Regulation in Homeostasis and Disease (B7), Banff, AB, Canada #KSstemcell PI 3-Kinase and Interplay with Other Signaling Pathways (X3) joint with Tumor Metabolism (X4), Keystone, CO, USA #KSPI3K / #KScancer March 2013 Structural Analysis of Supramolecular Assemblies by Hybrid Methods (C1), Tahoe City, CA, USA #KSsupramolecular Understanding Dendritic Cell Biology to Advance Disease Therapies (C2), Keystone, CO, USA #KSdendritic DNA Replication and Recombination (X5) joint with Genomic Instability and DNA Repair (X6), Banff, AB, Canada #KSDNA Growing to Extremes: Cell Biology and Pathology of Axons (C4), Tahoe City, CA, USA #KSaxon Host Response in Tuberculosis (X7) joint with Tuberculosis: Understanding the Enemy (X8), Whistler, BC, Canada #KSTB Precision Genome Engineering and Synthetic Biology: Designing Genomes and Pathways (C5), Breckenridge, CO, USA #KSgenome Neuronal Control of Appetite, Metabolism and Weight (C6), Banff, AB, Canada #KSobesity RNA Silencing (C7), Whistler, BC, Canada #KSrNA Epigenetic Marks and Cancer Drugs (C8), Santa fe, NM, USA #KScancer April 2013 Molecular Clockworks and the Regulation of Cardio-Metabolic Function (C9), Snowbird, Utah, USA #KScardio Immune Activation in HIV Infection: Basic Mechanisms and Clinical Implications (D2), Breckenridge, CO, USA #KShIV Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction (D3), Alpbach, Austria #KSnuclear Immunopathology of Type 1 Diabetes (Z1) joint with Advances in the Knowledge and Treatment of Autoimmunity (Z2), Whistler, BC, Canada #KSdiabetes / #KSautoimmunity Cardiac Remodeling, Signaling, Matrix and Heart Function (D4), Snowbird, UT, USA #KScardio Plant Immunity: Pathways and Translation (D5), Big Sky, MT, USA #KSplant Positive Strand RNA Viruses (D7), Boston, MA, USA #KSrNA May 2013 The Innate Immune Response in the Pathogenesis of Infectious Disease (E1), Ouro Preto, MG, Brazil #KSimmunity The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer (E2), Monterey, CA, USA #KShippo June 2013 Human Genomics and Personalized Medicine (E3), Stockholm, Sweden #KSgenome PO Box 1630 | 160 US highway 6, Suite 200 Silverthorne, Colorado 80498 | USA 1.970.262.1230 | 1.800.253.0685 (US & Canada) www.keystonesymposia.org/meetings Scan the QR code to the right with your mobile device to view this list online. printed on 10% post-consumer-waste recycled paper Follow us: a 501(c)(3) nonproft educational organization WELCOME TO THE 20122013 KEYSTONE SYMPOSIA CONFERENCE SERIES We are pleased to bring you another season of focused yet cross-disciplinary conferences on exciting, new frontiers in the life sciences. This season gets underway in September please pay close attention to rapidly approaching abstract, scholarship and early/discounted registration deadlines. You will notice that, in response to attendee feedback, the keynotes for many meetings have been moved to the moining of the iist full uay This scheuule allows you moie lexibility foi youi tiavel so that upon arrival you can register for the meeting, settle in to your lodging, and review the program and abstract book before the meeting starts the next morning. Precise schedules vary and are still subject to change; as always inu the most uptouate scheuules on oui website at www.keystonesymposia.org/meetings. NEW LOCATIONS We aie exciteu to announce oui iistevei confeience in South Ameiica The Innate Immune Response in the Pathogenesis of Infectious Disease which will take place in 0uio Pieto Biazil in Nay We aie also looking foiwaiu to ietuining to Stockholm foi a seconu time foi Human Genomics and Personalized Medicine in }une 0thei new locations in oui seiies incluue Tokyo Aging and Diseases of Aging), Montreal Autophagy, Inlammation and Immunity anu New 0ileans Malaria). In addition, we will convene a ulobal Bealth Seiies confeience in 0ttawa in Becembei Immunological Mechanisms of Vaccination). CALL FOR ABSTRACTS Consider submitting an abstract to present during one of the sessions listed on the following pages. Scientiic oiganizeis ieview postei abstiacts to choose piesenteis foi woikshops plenaiy sessions anu poster sessions. Presenting your research in any part of the program is a great opportunity for feedback and collaboration. FINANCIAL AID Keystone Symposia offers a variety of scholarships and travel awards to help offset registration, lodging anu tiavel costs Thanks to many geneious uonois we weie able to awaiu moie than scholaiships to students and postdoctoral fellows as well as travel awards to developing country investigators in our season We uige all eligible canuiuates to ieview oui vaiious oppoitunities foi inancial aiu on page 4 or online at www.keystonesymposia.org/inancialaid. FOLLOW US Follow us on Facebook and Twitter or join our e-mail list to stay abreast of the most recent developments as we head into the new season. We encourage you to post photos, videos or anecdotes throughout the season of your favorite conference moments on our Facebook page at facebook.com/ KeystoneSymposia. Tag us in your tweets using @KeystoneSymp, subscribe to our YouTube channel at youtube.com/KeystoneSymposia and join our group on LinkedIn. TABLE OF CONTENTS Conference Index .......................... pg 3 Submitting an Abstract .................. pg 4 Scholarships and Travel Awards ....... pg 4 Registration Rates ......................... pg 5 Registration Information ................ pg 5 Travel Tips ................................... pg 6 Global Health Series ...................... pg 6 20122013 Conference Programs ..... pg 763 Financial Support .......................... pg 6465 Board of Directors and Staff ............ pg 66 Scientic Advisory Board ................ pg 67 Conference Listings by Month ......... Back Cover 20122013 KEYSTONE SYMPOSIA CONFERENCES 3 Pulmonary Vascular Disease and Right Ventricular Dysfunction:
Current Concepts and Future Therapies (S1) .................................................................................. Monterey, CA, USA ................... Sep 1015 .............. pg 7 Aging and Diseases of Aging (S2) ........................................................................................... Tokyo, Japan .......................... Oct 2227 .............. pg 8 Immunological Mechanisms of Vaccination (S3)
.................................................................... Ottawa, ON, Canada ................. Dec 1318 .............. pg 9
Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1) joint with Pathogenic Processes in Asthma and COPD (J2) .......................................................................... Santa Fe, NM, USA ................... Jan 1015 ........ pg 10-11 Multiple Sclerosis (A1) .......................................................................................................... Big Sky, MT, USA ..................... Jan 1116 .............pg 12 New Frontiers in Cardiovascular Genetics Beyond GWAS (A2) .....................................................Tahoe City, CA, USA ................. Jan 1318 .............pg 13 Frontiers of NMR in Biology (A3) .............................................................................................. Snowbird, UT, USA ................... Jan 1318 .............pg 14 Hematopoiesis (A4) ..................................................................................................................Steamboat Springs, CO, USA ...... Jan 1419 .............pg 15 Emerging Topics in Immune System Plasticity: Cellular Networks, Metabolic Control and Regeneration (A5)..................................................... Santa Fe, NM, USA ................... Jan 1520 .............pg 16 Plant Abiotic Stress and Sustainable Agriculture: Translating Basic Understanding to Food Production (A6) ......................................................... Taos, NM, USA ........................ Jan 1722 .............pg 17 Noncoding RNAs in Development and Cancer (A7) .................................................................... Vancouver, BC, Canada ............. Jan 2025 .............pg 18 Malaria (A8)
...................................................................................................................... New Orleans, LA, USA .............. Jan 2025 .............pg 19
Metabolic Control of Inammation and Immunity (A9) ............................................................ Breckenridge, CO, USA .............. Jan 2126 .............pg 20 Antibodies as Drugs (J3) joint with Cancer Immunology and Immunotherapy (J4) ............................................................................Vancouver, BC, Canada ............. Jan 27Feb 1 .... pg 22-23 Adipose Tissue Biology (J5) joint with Diabetes New Insights into Mechanism of Disease and its Treatment (J6)............................... Keystone, CO, USA ................... Jan 27Feb 1 .... pg 24-25 Mitochondria, Metabolism and Myocardial Function Basic Advances to Translational Studies (B1) ........................................................................... Keystone, CO, USA ................... Feb 38 ................pg 26 Neurogenesis (J7) joint with New Frontiers in Neurodegenerative Disease Research (J8) ...................................................... Santa Fe, NM, USA ................... Feb 38 ........... pg 28-29 Lung Development, Cancer and Disease (B2) ...................................................................................... Taos, NM, USA ........................ Feb 510 ...............pg 30 The Gut Microbiome: The Effector/Regulatory Immune Network (B3)......................................... Taos, NM, USA ........................ Feb 1015 .............pg 31 B Cell Development and Function (X1) joint with HIV Vaccines (X2)
............................................................................................................... Keystone, CO, USA ................... Feb 1015 ........ pg 32-33
Autophagy, Inammation and Immunity (B4) .......................................................................... Montreal, QC, Canada ............... Feb 1722 .............pg 34 Nutrition, Epigenetics and Human Disease (B5).......................................................................... Santa Fe, NM, USA ................... Feb 1924 .............pg 35 Myeloid Cells: Regulation and Inammation (B6) .......................................................................Keystone, CO, USA ................... Feb 1924 .............pg 36 Stem Cell Regulation in Homeostasis and Disease (B7) ............................................................ Banff, AB, Canada ................... Feb 24Mar 1 .........pg 37 PI 3-Kinase and Interplay with Other Signaling Pathways (X3) joint with Tumor Metabolism (X4) ......................................................................................................... Keystone, CO, USA ................... Feb 24Mar 1 .... pg 38-39 Structural Analysis of Supramolecular Assemblies by Hybrid Methods (C1) ................................ Tahoe City, CA, USA ................. Mar 37 ................pg 40 Understanding Dendritic Cell Biology to Advance Disease Therapies (C2) ................................... Keystone, CO, USA ................... Mar 38 ................pg 41 DNA Replication and Recombination (X5) joint with Genomic Instability and DNA Repair (X6) ................................................................................ Banff, AB, Canada ................... Mar 38 ........... pg 42-43 Growing to Extremes: Cell Biology and Pathology of Axons (C4) ................................................ Tahoe City, CA, USA ................. Mar 1015 .............pg 44 Host Response in Tuberculosis (X7) joint with Tuberculosis: Understanding the Enemy (X8)
........................................................................ Whistler, BC, Canada ................ Mar 1318 ........ pg 46-47
Precision Genome Engineering and Synthetic Biology: Designing Genomes and Pathways (C5) ................................................................................... Breckenridge, CO, USA .............. Mar 1722 .............pg 48 Neuronal Control of Appetite, Metabolism and Weight (C6) ...................................................... Banff, AB, Canada ................... Mar 1722 .............pg 49 RNA Silencing (C7) .................................................................................................................... Whistler, BC, Canada ................ Mar 1924 .............pg 50 Epigenetic Marks and Cancer Drugs (C8) .....................................................................................Santa Fe, NM, USA ................... Mar 2025 .............pg 51 Molecular Clockworks and the Regulation of Cardio-Metabolic Function (C9) .............................. Snowbird, UT, USA ................... Apr 37 ................pg 52 Immune Activation in HIV Infection: Basic Mechanisms and Clinical Implications (D2)
............ Breckenridge, CO, USA .............. Apr 38 ................pg 54
Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction (D3) ......................................................... Alpbach, Austria ..................... Apr 38 ................pg 55 Immunopathology of Type 1 Diabetes (Z1) joint with Advances in the Knowledge and Treatment of Autoimmunity (Z2) ............................................. Whistler, BC, Canada ................ Apr 49 ........... pg 56-57 Cardiac Remodeling, Signaling, Matrix and Heart Function (D4) ................................................ Snowbird, UT, USA ................... Apr 712 ...............pg 58 Plant Immunity: Pathways and Translation (D5) ......................................................................... Big Sky, MT, USA ..................... Apr 712 ...............pg 59 Positive Strand RNA Viruses (D7) .............................................................................................. Boston, MA, USA ..................... Apr 28May 3 ........pg 60 The Innate Immune Response in the Pathogenesis of Infectious Disease (E1)
.......................... Ouro Preto, MG, Brazil.............. May 1015 ............pg 61
The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer (E2) .............................................................. Monterey, CA, USA ................... May 1923 ............pg 62 Human Genomics and Personalized Medicine (E3) ...................................................................... Stockholm, Sweden ................. Jun 1721 .............pg 63 GREEN TYPE INDICATES STANDALONE MEETINGS | BLUE TYPE INDICATES JOINT MEETINGS |
PART OF THE KEYSTONE SYMPOSIA GLOBAL HEALTH SERIES
SUBMITTING AN ABSTRACT Keystone Symposia strongly encourages submission of an abstract when registering for a conference; however, abstracts are not required for registration unless you are applying for a scholarship. Presenting your abstract during your conference poster session gives excellent exposure to your work and the opportunity to interact with many different investigators and receive valuable feedback. Organizers also review all submitted abstracts to select oral presenters for plenary sessions and workshops. Selections are made based on quality and relevance to the session, and invitations are issued by Keystone Symposia. To maintain fairness of the selection process, requests to speak will not be accepted. Abstracts will be published in a non-accredited journal which is distributed to conference participants and also available for purchase after the conference. If you do not submit an abstract or submit it too late for publication, you may still be able to display a poster on-site on a space-available basis. You can view our abstract formatting guidelines online at www.keystonesymposia.org/abstracts. Please contact us at 1.800.253.0685 (US & Canada) or 1.970.262.1230 or email us at abstracts@keystonesymposia.org if you have additional questions about abstracts and posters that are not answered here or on our website. Please note that submission of your abstract does not constitute registration. ABSTRACT SUBMISSION RATES Abstracts submitted by the early abstract deadline: 50 USD If your abstract is accepted, the 50 USD will be applied toward your registration payment. Abstracts submitted after the early abstract deadline (before the late-breaking abstract deadline): 100 USD If your abstract is accepted, 50 USD will be applied toward your registration payment; the remaining 50 USD is non-refundable. SPEAKERS AND ORGANIZERS If you are an organizer or invited speaker, please refer to correspondence from the Keystone Symposia Program Implementation Department for registration, abstract submission, travel, lodging and other information. SCHOLARSHIPS AND TRAVEL AWARDS We strive to make our conferences as accessible as possible to new investigators, including students and postdoctoral fellows, as they provide excellent networking anu mentoiing oppoitunities Foui types of inancial assistance aie available in addition to our discounted student registration rates (student rates are listed on the next page): KEYSTONE SYMPOSIA SCHOLARSHIPS These are available for students and postdoctoral fellows; the number varies depending on funding from the National Institutes of Health, the National Science Foundation, Keystone Symposias Future of Science Fund and other sources. Scholarship recipients will be selected based on the quality of science of their submitted abstracts and the relevance of the abstract to the confeience topic Awaius aie up to 0SB in valueApply anu view ueaulines online at www.keystonesymposia.org/scholarships. UNDERREPRESENTED MINORITY SCHOLARSHIPS Scholarships of up to 1,200 USD are available for US citizens or permanent residents who are graduate students or postdoctoral fellows currently enrolled in an academic program and who belong to one of the following ethnic groups: Hispanic/Latino, Black/African American (not of Hispanic origin), American Indian/Alaska Native or Native Hawaiian/ Paciic Islanuei Foi moie infoimation visit www.keystonesymposia.org/URMscholarship. EARLY-CAREER INVESTIGATOR TRAVEL AWARDS A limited number of these awards will be given to fund up to 1,800 USD in conference costs for assistant professors (or the industry equivalent) from an underrepresented minority (URM) background (African-American, LatinoBispanic Paciic Islanuei oi Native AmeiicanAlaska Native who aie 0S citizens oi peimanent iesiuents Canuiuates must be willing to mentor a young URM investigator for one year after the conference. Please visit www.keystonesymposia.org/ EarlyCareerAward to download an application and for more information on the particular deadlines associated with these Awards. GLOBAL HEALTH TRAVEL AWARDS Awards covering meeting registration and travel/lodging expenses are available for students, postdoctoral fellows, investigators and clinicians originating from a nation affected by health problems of the meetings in our ulobal BealthSeiies Piefeience will be given to inuiviuuals tiaveling fiom anu ietuining to affecteu nations oi inuiviuuals cuiiently studying in one country but planning to return to work in an affected nation. The 20122013 Global Health Series meetings are listed on page 6. Visit www.keystonesymposia.org/GlobalHealth to learn more. ATTENDING A KEYSTONE SYMPOSIA CONFERENCE 4 20122013 REGISTRATION RATES CONFERENCES IN THE US AND BRAZIL Four-Day Programs Early/Discounted Registration: 745 USD / 520 USD student Regular Registration: 895 USD / 670 USD student Three-Day Programs Early/Discounted Registration: 695 USD / 470 USD student Regular Registration: 845 USD / 620 USD student CONFERENCES IN CANADA AND EUROPE Early/Discounted Registration: 795 USD / 570 USD student Regular Registration: 945 USD / 720 USD student Note: Pro-rated registration rates are not available. Registration rates include admission to plenary sessions, workshops and poster sessions; one copy of the abstract book; breakfast (in most locations check online programs for speciics; coffee breaks; and social hours. Social hours take place before or during poster sessions and vary from light appetizers to buffets. Registration rates do not include lodging and transportation. Inclusion of lunch or dinner in registration rates varies by site. REGISTERING FOR A KEYSTONE SYMPOSIA CONFERENCE ONLINE The easiest way to register is through our secure website, with payment by credit card. If you have ever attended a Keystone Symposia meeting, you already have an account on our site. After logging in or creating your account, you will be able to register for a conference and submit your abstract online. You will also be able to: Euit youi abstiact view anu piint speakei anu postei abstiacts foi the confeiences foi which you aie iegisteieu uays befoie penuing authoi approval) and 30 days after the conference; view anu piint full paiticipant lists foi the confeiences foi which you aie iegisteieu Euitupuate youi contact infoimation anu mailemail piefeiences view anu piint invoices attenuance letteis invitation letteis anu scholaiship status Access oui ioommate bulletin boaiu FAX/MAIL Registration forms are available for download on our website. Fax your form to 1.970.262.1525 or mail it to Keystone Symposia, 160 US Highway 6, Suite 200, PO Box 1630, Silverthorne, CO 80498-1630, USA. Registration form and payment must be received by the early/discounted registration deadline in order to receive that rate. PHONE Call our Attendee Services Department at 1.800.253.0685 (US & Canada) or 1.970.262.1230 uuiing iegulai ofice houis 7:30 a.m. to 4:00 p.m. (US Mountain Time). Please have your credit card ready. ON-SITE You may also register on-site once the conference convenes, although there is a possibility that the conference or some of its sessions may already be full, and you will also not be eligible for the early/discounted registration rate. On-site registrations must be paid via credit card. CANCELLING YOUR REGISTRATION Registrants who do not cancel according to the following guidelines will forfeit all fees. All cancellations substitutions oi changes must be iequesteu two weeks piioi to the stait of the confeience Registiations aie tiansfeiable to othei confeiences in the same season 0R to a colleague foi the oiiginal meeting Please see oui website foi speciic iequiiements You must email wiite oi fax youi iequest to Keystone Symposia Louging anu tianspoitation must be cancelleu uiiectly with the iesoit anuoi tianspoitation company Registiation iefunus will be piocesseu within uays If you notify Keystone Symposia of youi cancellation at least uays piioi to the confeience stait uate you will ieceive a full refund minus a 150 USD handling fee, a 50 USD abstract fee (if applicable) and the 50 USD fee for late abstract submission (after the deadline) if applicable. If you notify Keystone Symposia of youi cancellation less than uays piioi to the confeience stait uate you will not ieceive a refund. ARRANGE FOR LODGING AND TRANSPORTATION Make your lodging arrangements early as space is limited. Keystone Symposia has contracted discounted conference rates with various lodging establishments; please refer to the meeting page on our website for louging infoimation speciic to each site anu to view iesoit contact infoimation Naps anu tianspoitation tips aie also available on our website to aid you in booking your airfare and ground transportation. ATTENDING A KEYSTONE SYMPOSIA CONFERENCE 5 TRAVEL TIPS FINDING LODGING All lodging forms and rates are located on our website under the Lodging/Hotels tab on the meeting page or in the My Account portal once you login to our site. Keystone Symposia is not responsible for lodging arrangements; however, we have negotiated special group rates and will endeavor to help you resolve related problems you may have. Please note the following: Special gioup iates aie typically a package ueal foi the uuiation of the confeience ive nights foi fouiuay confeiences anu four nights for three-day conferences). If you choose not to stay for all the nights of the package, you will still have to pay the full package price. If you know you cannot attend the entire conference, your costs may be less by securing a daily rate directly with the lodging establishment. Identify yourself as part of Keystone Symposia when you reserve your lodging. Some sitebaseu activity uiscounts may be available to attenuees anu theii guests Such activities aie often weatheiuepenuent and are not guaranteed. Please call the resort or hotel with questions. To save on louging expenses consiuei shaiing a ioom visit oui ioommate bulletin boaiu unuei the FAQ tab on oui home page to inu a ioommate CANCELLING LODGING Lodging and transportation must be cancelled directly with the resort and/or transportation company. Cancellation policies vaiy contact youi speciic hotel foi uetails OBTAINING A CAR RENTAL DISCOUNT Visit our website or contact Avis directly at 1.800.331.1600 (in US & Canada) and reference the Avis Worldwide Discount (AWD) code T487899. Reservations may also be made online at www.avis.com by entering the same AWD code under rates and discounts. PASSPORT AND VISA GUIDELINES Due to the constantly changing nature of travel, we urge attendees to research their own travel speciications incluuing passpoit anu visa iequiiements uocumentation foi ieentiy into theii countiy of iesiuence anu any othei iuentiication neeueu Please allow suficient time in auvance of the meeting foi the piocessing of such uocumentation ADDITIONAL TRAVEL SUGGESTIONS Due to limited ground transportation opportunities at many airports, we recommend that your light is scheuuleu to aiiive by pm anu to uepait no eailiei than am If aiiiving outsiue of these times please coniim youi ground transportation prior to booking your airfare. Please note all suggested arrival dates on the meeting pages in this catalog. Book all giounu tianspoitation in auvance While at the confeience ieconiim youi ietuin ieseivations Infoimation iegaiuing giounu transportation companies is listed on our website. Tiavel anu louging infoimation is pioviueu as a couitesy Keystone Symposia has no afiliation with the pioviueis ATTENDING A KEYSTONE SYMPOSIA CONFERENCE 20122013 GLOBAL HEALTH SERIES Breaking the Cycle of Infectious Disease 6 The Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation, aims to help break the cycle of infectious uisease thiough meetings on uiffeient uisease topics Keystone Symposia offeis inancial aiu in the foim of ulobal Bealth Travel Awards to individuals from affected nations, or individuals currently studying in one country but planning to return to work in an affected nation. Visit www.keystonesymposia.org/GlobalHealth for more information about these Travel Awards including eligibility and applications. The 2012-2013 Global Health Series meetings are: IMMUNOLOGICAL MECHANISMS OF VACCINATION (page 9) Global Health Travel Award Application Deadline: July 17, 2012 MALARIA (page 19) Global Health Travel Award* Application Deadline: August 21, 2012 *Travel award funding provided by Medicines for Malaria Venture Ian Bathurst Global Health Travel Awards in addition to the Bill & Melinda Gates Foundation HIV VACCINES (page 33) Global Health Travel Award Application Deadline: September 11, 2012 TUBERCULOSIS: UNDERSTANDING THE ENEMY (page 47) Global Health Travel Award Application Deadline: October 16, 2012 IMMUNE ACTIVATION IN HIV INFECTION: BASIC MECHANISMS AND CLINICAL IMPLICATIONS (page 54) Global Health Travel Award Application Deadline: November 6, 2012 THE INNATE IMMUNE RESPONSE IN THE PATHOGENESIS OF INFECTIOUS DISEASE (page 61) Global Health Travel Award Application Deadline: December 11, 2012 PULMONARY VASCULAR DISEASE AND RIGHT VENTRICULAR DYSFUNCTION: CURRENT CONCEPTS AND FUTURE THERAPIES SEPTEMBER 1015, 2012 PORTOLA HOTEL & SPA, MONTEREY, CALIFORNIA, USA (venue information on page 21) You can still register for this meeting through September 10, 2012. To inquire about submitting a late-breaking abstract, please contact our ofce: abstracts@keystonesymposia.org, 1.800.253.0685 (US & Canada) or 1.970.262.1230. WWW.KEYSTONESYMPOSIA.ORG/12S1 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/12S1. MONDAY, SEPTEMBER 10: ARRIVAL & REGISTRATION TUESDAY, SEPTEMBER 11 Keynote Address Stefanie Dimmeler, University of Frankfurt, Germany The Role of Stem Cells in Angiogenesis and Vascular Repair The Role of Stem Cells, Progenitor and Differentiated Blood Cells in Pulmonary Vascular Disease and Repair Duncan Stewart*, Ottawa Hospital Research Institute, Canada Stella Kourembanas, Childrens Hospital Boston, Harvard Medical School, USA Role of Bone Marrow Stromal Cells in the Repair of Chronic Lung and Pulmonary Vascular Disease Margaret R. MacLean, University of Glasgow, UK Platelet Function, Serotonin and Pulmonary Vascular Disease Paul Hassoun, Johns Hopkins University, USA Cross-Talk between Macrophages, Granulocytes and Vascular Cells in Pulmonary Arterial Hypertension Duncan Stewart, Ottawa Hospital Research Institute, Canada Progenitor Cell Transplantation and Gene Therapy for Pulmonary Arterial Hypertension Short Talk Chosen from Abstracts Workshop 1: How to Translate Basic Research Findings into Improvement of Patient Care The Role of Industry Daniel Burkhoff, Columbia University, USA New Devices for PH-Noninvasive Monitoring of Cardiac Output and RV Assist Devices Matthew Thomas, Novartis Institutes for BioMedical Research, UK Anti-Remodeling Therapies for Pulmonary Arterial Hypertension: Challenges for Drug Discovery Stuart Rich*, University of Chicago Medical Center, USA (panelist) Timothy M. Moore, NHLBI, National Institutes of Health, USA (panelist) Growth Factors, TGF-/BMP Signaling and Pulmonary Vascular Disease Georg Hansmann*, Childrens Hospital Boston, Harvard Medical School, USA Paul Hassoun*, Johns Hopkins University, USA Marc Humbert, Hpital Antoine-Bclre, AP-HP, France New Insights into the Role of Cytokines, Chemokines and Growth Factors in Pulmonary Arterial Hypertension Kenneth D. Bloch, Massachusetts General Hospital, USA Role of BMPR-2 and BMP Signaling in PAH Lessons from Murine Models Patricia Thistlethwaite, University of California, San Diego, USA Notch Signaling in Pulmonary Vascular Disease Short Talk Chosen from Abstracts WEDNESDAY, SEPTEMBER 12 Metabolic Regulators in Pulmonary Vascular Disease Stephen L. Archer*, University of Chicago Medical Center, USA Peter F. Carmeliet, University of Leuven, Belgium Vascular Metabolomics Georg Hansmann, Childrens Hospital Boston, Harvard Medical School, USA The Protective Role of PPAR in Pulmonary Vascular Disease Evangelos D. Michelakis, University of Alberta, Canada Mitochondrial Modulators in Pulmonary Arterial Hypertension Nicholas Morrell, University of Cambridge, UK Generation of Patient-Derived Induced Pluripotent Stem Cells to Study BMP Receptor Dysfunction Short Talk(s) Chosen from Abstracts Workshop 2: MicroRNAs and iPS Cells Novel Tools and Targets in Cardiovascular Biology and Pulmonary Vascular Research Nicholas Morrell*, University of Cambridge, UK Short Talks Chosen from Abstracts The Right Ventricle in Pulmonary Hypertension: Cardiomyocyte Function and Hemodynamic Performance Evangelos Michelakis*, University of Alberta, Canada Kurt R. Stenmark*, University of Colorado Denver, USA Stephen L. Archer, University of Chicago Medical Center, USA Right Ventricular Cardiomyocyte Function: Impact of Pressure, Volume Load and PH Therapy WEDNESDAY, SEPTEMBER 12 (CONTINUED) Titus Kuehne, German Heart Institute, Germany Assessment of Right Ventricular Function by MRI and Pressure-Volume Loops Andrew Redington, Hospital for Sick Children, Canada Interactions between Right and Left Ventricle in Pulmonary Hypertension Short Talk Chosen from Abstracts THURSDAY, SEPTEMBER 13 MicroRNAs in Proliferative Vascular Disease Margaret R. MacLean*, University of Glasgow, UK Andrew H. Baker, University of Glasgow, UK MicroRNAs in Vascular Remodeling and PAH Norbert Voelkel, Virginia Commonwealth University, USA Histone (Deacetylation in the Right Ventricle and Pulmonary Vasculature Joseph Loscalzo, Brigham and Womens Hospital, Harvard Medical School, USA Hypoxamirs in the Pulmonary Endothelium Sebastien Bonnet, Universit Laval, Canada Role for DNA Repair and miRNAs in the Epigenetics Abnormalities Seen in PAH Short Talk(s) Chosen from Abstracts Innovative Clinical PAH Trials Stuart Rich, University of Chicago Medical Center, USA Clinical Trial Design for Pulmonary Hypertension H. Ardeschir Ghofrani, Justus Liebig University Giessen, Germany Preliminary/Unpublished Results Randomized Controlled Trial Mark Nicolls, Stanford University School of Medicine, USA Targeting Immunity in the Treatment of PAH: The Rituximab SSc-PAH Trial Short Talk Chosen from Abstracts FRIDAY, SEPTEMBER 14 Pulmonary Hypertension in Parenchymal Lung and Thromboembolic Diseases Stella Kourembanas*, Childrens Hospital Boston, Harvard Medical School, USA Mark A. Krasnow*, Stanford University School of Medicine, USA Building the Pulmonary Artery Bernard Thbaud, University of Alberta, Canada Progenitor Cells in Diaphragmatic Hernia, Pulmonary Hypoplasia and PH Associated with Neonatal Lung Injury Jane A. Mitchell, Imperial College London, UK The Role of PPAR in Pulmonary Hypertension and Idiopathic Pulmonary Fibrosis Stuart W. Jamieson, University of California, San Diego Medical Center, USA Unique Features of Chronic Thromboembolic Pulmonary Hypertension Short Talk(s) Chosen from Abstracts Workshop 3: Vascular Metabolomics and Proteomics: Where Are the Novel Biomarkers for Pulmonary Vascular Diseases? Martin R. Wilkins*, Imperial College London, UK Short Talks Chosen from Abstracts Pulmonary Arterial Hypertension Current Concepts and Future Therapies Stephen L. Archer*, University of Chicago Medical Center, USA Georg Hansmann*, Childrens Hospital Boston, Harvard Medical School, USA Margaret R. MacLean*, University of Glasgow, UK Short Talk(s) Chosen from Abstracts Novel Therapeutic Targets for PAH and RV Dysfunction Kurt R. Stenmark, University of Colorado Denver, USA The Microenvironment in Vascular Remodeling and Repair: Inlammatory Fibroblasts and Beyond Jeffrey Fineman, University of California, San Francisco, USA Systemic-to-Pulmonary Shunts: How Vascular Gene Expression and Function Depend on Pulmonary Blood Flow and Pressure Martin R. Wilkins, Imperial College London, UK Novel Biomarkers for Pulmonary Vascular Disease and RV Dysfunction Timothy M. Moore, NHLBI, National Institutes of Health, USA (panelist) SATURDAY, SEPTEMBER 15: DEPARTURE *Session Chair 7 Scientic Organizers: Georg Hansmann, Stephen L. Archer and Margaret R. MacLean Sponsored by Bayer USA Foundation AGING AND DISEASES OF AGING OCTOBER 2227, 2012 SHERATON MIYAKO HOTEL TOKYO, TOKYO, JAPAN (venue information on page 21) DEADLINES: ABSTRACT & SCHOLARSHIP CLOSED LATE-BREAKING ABSTRACT JUL 25, 2012 DISCOUNTED REGISTRATION AUG 22, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/12S2 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/12S2. MONDAY, OCTOBER 22: ARRIVAL & REGISTRATION TUESDAY, OCTOBER 23 Keynote Address David A. Sinclair, Harvard Medical School, USA Sirtuins, Aging and Diseases of Aging Cell Signaling I Leonard P. Guarente, Massachusetts Institute of Technology, USA Aging and Disease: Connections to Sirtuins Heidi Tissenbaum, University of Massachusetts Medical School, USA Regulation of Lifespan by C. elegans FOXO/DAF-16 Eisuke Nishida, Kyoto University, Japan JNK/AP-1 Signaling and Longevity in C. elegans Laura Bordone, Genomics Institute of the Novartis Foundation, USA SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells Cell Signaling II Sean M. Oldham, Sanford-Burnham Medical Research Institute, USA The Role of the TOR Pathway in Obesity and Aging Shin-ichiro Imai, Washington University School of Medicine, USA The Systemic Regulatory Network for Mammalian Aging and Longevity: The Brain, SIRT1 and the NAD World Yousin Suh, Albert Einstein College of Medicine, USA Functional Genomics of Human Aging Short Talk Chosen from Abstracts WEDNESDAY, OCTOBER 24 Stem Cells and Aging Session Sponsored by The Ellison Medical Foundation (Support for these organizer-selected speakers generously provided by this foundation *Kazuo Tsubota, Keio University School of Medicine, Japan Thomas A. Rando, Stanford University School of Medicine, USA Muscle Stem Cells and Aging Heinrich Jasper, University of Rochester, USA Aging of Intestinal Stem Cells in Drosophila Anne Brunet, Stanford University, USA Epigenetic Regulation of Neural Stem Cell Aging Amy J. Wagers, Harvard University, USA Tissue Maintenance and Stem Cells Short Talk(s) Chosen from Abstracts Cell Signaling III Yo-ichi Nabeshima, Foundation for Biomedical Research and Innovation, Japan -Klotho as a Regulator of Calcium Homeostasis and Aging-Like Phenotype Noboru Mizushima, Tokyo Medical and Dental University, Japan Nutrient Signaling and Autophagy Toren Finkel, NHLBI, National Institutes of Health, USA Mitochondrial Dysfunction, Oxidative Stress and Autophagy Short Talk Chosen from Abstracts THURSDAY, OCTOBER 25 DNA Damage Response, Telomeres and Cellular Senescence Judith Campisi, Buck Institute for Research on Aging, USA The DNA Damage Response, Inlammation and Aging Manuel Serrano, Spanish National Cancer Center (CNIO), Spain Tumor Suppressors at the Interface between Cancer and Aging Fuyuki Ishikawa, Kyoto University, Japan Telomere and Cellular Senescence Cynthia T. McMurray, Lawrence Berkeley National Laboratory, USA The Role of DNA Damage Response Signals in Neurodegenerative Diseases Short Talk(s) Chosen from Abstracts Age-Related Neurodegenerative Diseases Ana Maria Cuervo, Albert Einstein College of Medicine, USA Role of Autophagy in Neurodegenerative Diseases Andrew G. Dillin, The Salk Institute for Biological Studies, USA Aging as an Event of Proteostasis Collapse Dale E. Bredesen, Buck Institute for Research on Aging, USA Role of Cell Death Signaling in Alzheimers Disease Short Talk Chosen from Abstracts FRIDAY, OCTOBER 26 Aging and Metabolic Diseases Takashi Kadowaki, University of Tokyo, Japan The Role of Adiponectin and Adiponectin Receptors in Type 2 Diabetes and Metabolic Diseases Juleen R. Zierath, Karolinska Institutet, Sweden Gene/Environment Inluence in Skeletal Muscle Insulin Sensitivity in Type 2 Diabetes Patients Carlos Canto Alvarez, cole Polytechnique Fdrale de Lausanne (EPFL), Switzerland Modulating NAD + Levels for Targeting Metabolic Disorders and Age-Related Physiological Decline Eric M. Verdin, University of California, San Francisco, USA SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism Short Talk(s) Chosen from Abstracts Aging and Cardiovascular Diseases Edward G. Lakatta, NIA, National Institutes of Health, USA The Stress of Aging Viewed from the Arterial Wall Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA Cardiac Aging in Drosophila Hiroshi Itoh, Keio University School of Medicine, Japan Metabolic Syndrome and Vascular Aging Short Talk Chosen from Abstracts SATURDAY, OCTOBER 27: DEPARTURE *Session Chair This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 8 Scientic Organizers: Takashi Kadowaki, Leonard P. Guarente, Judith Campisi and Sean M. Oldham Sponsored by Astellas Pharma Inc., Novartis Pharma K.K. and Takeda Pharmaceutical Company Limited IMMUNOLOGICAL MECHANISMS OF VACCINATION DECEMBER 1318, 2012 FAIRMONT CHTEAU LAURIER, OTTAWA, ONTARIO, CANADA (venue information on page 21) Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/12S3. DEADLINES: GLOBAL HEALTH TRAVEL AWARD JUL 17, 2012 ABSTRACT & SCHOLARSHIP AUG 13, 2012 LATE-BREAKING ABSTRACT SEP 13, 2012 DISCOUNTED REGISTRATION OCT 11, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/12S3 THURSDAY, DECEMBER 13: ARRIVAL & REGISTRATION Keynote Address Bruce A. Beutler, University of Texas Southwestern Medical Center, USA Genetics and Innate Immunity FRIDAY, DECEMBER 14 Innate Sensing of Pathogens and Vaccines Akiko Iwasaki
, Yale University School of Medicine, USA
Talk Title to be Determined Speaker to be Announced Dana Philpott, University of Toronto, Canada NOD Receptors and Adaptive Immunity William R. Heath, University of Melbourne, Australia Dendritic Cells and T Cell Induction Short Talk(s) Chosen from Abstracts Augmenting Immune Responses to Vaccines Robert A. Seder, NIAID, National Institutes of Health, USA Optimizing Adaptive Immunity with Immune Adjuvants Tania H. Watts, University of Toronto, Canada TNF Family Members in Acute and Chronic Infection: Implications for Vaccination Daniel D. Pinschewer, University of Geneva, Switzerland Recombinant LCMV Vaccine Vectors Short Talk Chosen from Abstracts SATURDAY, DECEMBER 15 T Cell Memory to Vaccines Ton N. Schumacher, Netherlands Cancer Institute, Netherlands Technologies for Tracking T Cell Responses John T. Harty, University of Iowa, USA Alternative Strategies for Generating Memory CD8 T Cells by Prime-Boost Immunization Marc K. Jenkins, University of Minnesota Medical School, USA CD4 + T Cell Memory David Masopust, University of Minnesota, USA CD8 T Cell Memory Induced by Heterologous Prime-Boost Vaccination Short Talk(s) Chosen from Abstracts B Cell Memory to Vaccines Antonio Lanzavecchia
, Institute for Research
in Biomedicine, Switzerland Talk Title to be Determined Michel C. Nussenzweig, Rockefeller University, USA Human Antibody Responses to HIV Shane Crotty, La Jolla Institute for Allergy and Immunology, USA Th Cells: Providing T Cell Help for B Cell Responses Short Talk Chosen from Abstracts SUNDAY, DECEMBER 16 Understanding Signatures of Vaccine Protective Eficacy Bali Pulendran, Emory University, USA Systems Vaccinology Ennio De Gregorio, Novartis Vaccines and Diagnostics, Italy Innate Immune Signatures of Vaccine Adjuvants Raick P. Skaly, Vaccine & Gene Therapy Institute, USA RNA Immunoproiling of Vaccines Susan M. Kaech, Yale University School of Medicine, USA Talk Title to be Determined Short Talk(s) Chosen from Abstracts Translating Immunity to Vaccines Dan H. Barouch, Harvard Medical School, Beth Israel Deaconess Medical Center, USA HIV Vaccine Design Helen McShane, University of Oxford, UK Clinical Development of TB Vaccines Speaker to be Announced Short Talk Chosen from Abstracts MONDAY, DECEMBER 17 Immunity and Vaccines Against Global Threats I Adrian V.S. Hill, University of Oxford, UK Malaria Vaccine Challenges Farshad Guirakhoo
Sanoi Pasteui 0SA
New Dengue Vaccines Rai Ahmed, Emory University School of Medicine, USA Immune Mechanisms in Inluenza Vaccination Dennis L. Kasper, Harvard Medical School, USA Immune Responses to Polysaccharide Vaccine Antigens Short Talk(s) Chosen from Abstracts Immunity and Vaccines Against Global Threats II Louis J. Picker, Oregon Health & Science University, USA Cytomegalovirus as a Vector for HIV Vaccines Jerald C. Sadoff, Crucell NV, Netherlands Vaccine Vectors for HIV and Other Global Threats Willem A. Hanekom, University of Cape Town, South Africa Field Studies of TB Vaccines Short Talk Chosen from Abstracts TUESDAY, DECEMBER 18: DEPARTURE
Invited, not yet accepted
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 9 Scientic Organizers: Adrian V.S. Hill, Dan H. Barouch, John T. Harty and Tania H. Watts Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation TYPE 2 IMMUNITY: INITIATION, MAINTENANCE, HOMEOSTASIS AND PATHOLOGY JANUARY 1015, 2013 SANTA FE COMMUNITY CONVENTION CENTER, SANTA FE, NEW MEXICO, USA (venue information on page 21) Scientic Organizers: Richard M. Locksley and Judith E. Allen Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J1. JOINT WITH... THURSDAY, JANUARY 10: ARRIVAL & REGISTRATION Keynote Address (Joint) Bart N. Lambrecht, Ghent University, Belgium The Dendritic Cell Network and the Response to Allergens FRIDAY, JANUARY 11 Adaptations to Chronic Helminth Infection Fred D. Finkelman, University of Cincinnati, USA Overview of Adaptations to Intestinal Helminths Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands Parasitic Helminths and the Human Immune Response Ajay Chawla, University of California, San Francisco, USA Metabolic Consequences of Type 2 Immunity Speaker to be Announced Short Talk(s) Chosen from Abstracts Regulating the Type 2 Cytokines Dirk E. Smith, Amgen Inc., USA The Role of IL-33 in Regulating Innate Airway Inlammation Steven F. Ziegler, Benaroya Research Institute and University of Washington School of Medicine, USA TSLP in the Regulation of Type 2 Immunity Richard M. Maizels, University of Edinburgh, UK Coaptation of the Host Immune Response by Parasitic Helminths Short Talk Chosen from Abstracts SATURDAY, JANUARY 12 Innate Helper Cells in Type 2 Immunity (Joint) Andrew N.J. McKenzie, Medical Research Council, UK Nuocytes, IL-33 and Lung Inlammation Hergen Spits, University of Amsterdam, Netherlands The Spectrum of Human Innate Lymphoid Cells Richard M. Locksley, University of California, San Francisco, USA Function-Marking Innate Helper Type 2 Cells Shigeo Koyasu, Keio University School of Medicine, Japan Type 2 Innate Immune Responses and the Natural Helper Cell Adaptive Th2 and TFH Cells Speakers to be Announced Shane Crotty, La Jolla Institute for Allergy and Immunology, USA Th2 Th Cell Determinants Short Talk Chosen from Abstracts SUNDAY, JANUARY 13 Commensals, Immunity and Epithelial Homeostasis Speaker to be Announced Wenjun Ouyang, Genentech, Inc., USA The IL-10/22 Family of Cytokines in Epithelial Health Yasmine Belkaid, NIAID, National Institutes of Health, USA Parasites and the Commensal Flora Sabine Eming, University of Cologne, Germany Tissue Repair and Type 2 Immunity Short Talk(s) Chosen from Abstracts Myeloid Cells in Tissue Homeostasis Judith E. Allen, University of Edinburgh, UK AAMs David Voehringer, University Hospital of Erlangen, Germany Eosinophils What Have We Learned? Hajime Karasuyama, Tokyo Medical and Dental University, Japan Basophils Innate Cells Regulated by the Adaptive Response Short Talk Chosen from Abstracts MONDAY, JANUARY 14 Initiating Type 2 Immunity (Joint) Ruslan M. Medzhitov
, Yale University School of Medicine, USA
Proteases Drive Allergic Inlammation Jenny P. Ting, University of North Carolina at Chapel Hill, USA Uric Acid and the Inlammasome Marco Idzko, University Hospital Freiburg, Germany ATP and P2X Receptors in Type 2 Immunity Jack A. Elias, Yale School of Medicine, USA Chitin and Chitinases Pathologic Syndromes Stuart G. Tangye, Garvan Institute of Medical Research, Australia Lymphocyte Defects in Hyper IgE Syndromes Thomas A. Wynn, NIAID, National Institutes of Health, USA Pathogenesis of Type 2 Immunity Lawren C. Wu, Genentech, Inc., USA IgE Production and Memory in Health and Disease Short Talk Chosen from Abstracts TUESDAY, JANUARY 15: DEPARTURE
Invited, not yet accepted
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 10 10 PATHOGENIC PROCESSES IN ASTHMA AND COPD Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J2. DEADLINES FOR BOTH CONFERENCES: ABSTRACT & SCHOLARSHIP SEP 10, 2012 LATE-BREAKING ABSTRACT OCT 10, 2012 DISCOUNTED REGISTRATION NOV 8, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13J1 or /13J2 Scientic Organizers: Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston Registering for one conference in a set of joint conferences enables participation in sessions of the other, pending space availability. THURSDAY, JANUARY 10: ARRIVAL & REGISTRATION Keynote Address (Joint) Bart N. Lambrecht, Ghent University, Belgium The Dendritic Cell Network and the Response to Allergens FRIDAY, JANUARY 11 New Insights into the Pathogenesis of Lung Diseases Sally E. Wenzel, University of Pittsburgh, USA Emerging Concepts on the Heterogeneity of Asthma Fernando D. Martinez, University of Arizona, USA Early-Life Origins of Chronic Obstructive Pulmonary Disease Avrum Spira, Boston University, USA Molecular Insights into COPD via Transcriptomic Proiling Ian M. Adcock, Imperial College London, UK Epigenetic Regulation of Lung Diseases Short Talk(s) Chosen from Abstracts Infectious Origins of Lung Disease James E. Gern, University of Wisconsin, USA Virus Infections and Asthma Inception and Exacerbation Sebastian L. Johnston, Imperial College London, UK Mechanisms of Rhinovirus-Induced Exacerbations in Asthma and COPD Michael J. Holtzman, Washington University, USA Immune Pathways Translating Viral Infection into Chronic Airway Disease Short Talk Chosen from Abstracts SATURDAY, JANUARY 12 Innate Helper Cells in Type 2 Immunity (Joint) Andrew N.J. McKenzie, Medical Research Council, UK Nuocytes, IL-33 and Lung Inlammation Hergen Spits, University of Amsterdam, Netherlands The Spectrum of Human Innate Lymphoid Cells Richard M. Locksley, University of California, San Francisco, USA Function-Marking Innate Helper Type 2 Cells Shigeo Koyasu, Keio University School of Medicine, Japan Type 2 Innate Immune Responses and the Natural Helper Cell Role of Th17 Cells in the Regulation of Lung Immunity Jay K. Kolls, University of Pittsburgh School of Medicine, USA Th17 Cells as Critical Regulators of Host Immunity to Bacterial and Fungal Infections at Mucosal Surfaces Susan V. Lynch, University of California, San Francisco, USA Airway Microbiota and Lung Disease Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA Microbiota Regulation of Th17-Mediated Severe Asthma Short Talk Chosen from Abstracts SUNDAY, JANUARY 13 Lung Development, Repair and Remodeling Jeffrey A. Whitsett, Cincinnati Childrens Hospital Medical Center, USA Transcriptional Networks Linking Mucus Metaplasia and Innate Immunity in the Respiratory Epithelium Paul W. Noble, Duke University, USA Matrix Regulation of Lung Injury, Inlammation and Repair Darryl Knight, University of British Columbia, Canada Stem Cells for Repair of the Airways Joanne L. Wright, University of British Columbia, Canada Cigarette-Smoke-Induced COPD Short Talk(s) Chosen from Abstracts Mechanisms of Chronic Obstructive Pulmonary Disease Shyam Biswal, Johns Hopkins Bloomberg School of Public Health, USA Oxidative Stress Regulation of Lung Inlammation in COPD Augustine Choi, Harvard Medical School, USA Regulation and Function of Autophagy in COPD Farrah Kheradmand, Baylor College of Medicine, USA Autoreactive T Cells in the Pathophysiology of Human and Mouse Emphysema Short Talk Chosen from Abstracts MONDAY, JANUARY 14 Initiating Type 2 Immunity (Joint) Ruslan M. Medzhitov
, Yale University School of Medicine, USA
Proteases Drive Allergic Inlammation Jenny P. Ting, University of North Carolina at Chapel Hill, USA Uric Acid and the Inlammasome Marco Idzko, University Hospital Freiburg, Germany ATP and P2X Receptors in Type 2 Immunity Jack A. Elias, Yale School of Medicine, USA Chitin and Chitinases Therapeutic Opportunities in Asthma and COPD Ruth Tal-Singer, GlaxoSmithKline, USA Challenges and Opportunities in COPD Drug Development John G. Matthews, Genentech, Inc., USA Anti-IL-13 Therapy in Asthma Alison L. Budelsky, Amgen Inc., USA Blockade of IL-17RA in Asthma Short Talk Chosen from Abstracts TUESDAY, JANUARY 15: DEPARTURE
Invited, not yet accepted
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 11 11 MULTIPLE SCLEROSIS JANUARY 1116, 2013 BIG SKY RESORT, BIG SKY, MONTANA, USA (venue information on page 21) Scientic Organizers: Trevor J. Kilpatrick, Brenda Banwell and Hartmut Wekerle Sponsored by Biogen Idec and the National Multiple Sclerosis Society DEADLINES: ABSTRACT & SCHOLARSHIP SEP 12, 2012 LATE-BREAKING ABSTRACT OCT 11, 2012 DISCOUNTED REGISTRATION NOV 12, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13A1 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A1. rleee FRIDAY, JANUARY 11: ARRIVAL & REGISTRATION SATURDAY, JANUARY 12 Keynote Address Trevor J. Kilpatrick*, University of Melbourne, Australia Lawrence Steinman, Beckman Center for Molecular Medicine, Stanford University, USA An Integrated and Evolutionary Perspective to Understanding the Pathogenesis of MS Nature and Nurture: Insights Beyond GWAS and Epidemiological Studies Sreeram Ramagopalan, University of Oxford, UK Implications of Epigenetic Changes in MS Justin Rubio, GlaxoSmithKline, UK Keys to Realizing the Promise of Pharmacogenomics Speaker to be Announced Short Talk(s) Chosen from Abstracts Cellular and Molecular Proiling: The Road to an Integrated Approach Hartmut Wekerle*, Max Planck Institut, Germany Lessons from Pathology William H. Robinson, Stanford School of Medicine, USA From Tissue to Proteomics and Lipidomics Ronald N. Germain, NIAID, National Institutes of Health, USA A Systems Biology Perspective to Autoimmunity Short Talk Chosen from Abstracts SUNDAY, JANUARY 13 Paraclinical Measures of Structural and Functional Change Elliot Frohman, University of Texas Southwestern Medical Center, USA Eye-ing a Window of Neuroprotection in the Visual System for Multiple Sclerosis John Gore, Vanderbilt University, USA Recent Developments in MRI Speaker to be Announced Martin Kerschensteiner, Ludwig-Maximilians-University Munich, Germany Harnessing the Potential of Cellular and Molecular in vivo Imaging Short Talk(s) Chosen from Abstracts Immunopathogenesis Jingwu Zhang Zang*, GlaxoSmithKline, China Marc Veldhoen, Babraham Institute, UK The Molecular Control of Immune Homeostasis Stephen M. Anderton, University of Edinburgh, UK Immune-Mediated Auto-Aggression and Regulation Takashi Yamamura, National Institute of Neuroscience, NCNP, Japan Interrogating Innate Immunity and Key Environmental Interactions Short Talk Chosen from Abstracts MONDAY, JANUARY 14 Clinical Controversies Helen Tremlett, University of British Columbia, Canada Emerging Concepts of Disease Heterogeneity in MS Timothy Coetzee, National Multiple Sclerosis Society, USA Lessons from CCSVI Jun-ichi Kira, Kyushu University, Japan Dissecting the Interface between NMO and MS Brenda Banwell*, University of Toronto, Canada Negotiating between ADEM, CIS and MS: An Age-Speciic Roadmap? Short Talk(s) Chosen from Abstracts Clinical Developments Richard K. Burt, Northwestern University, USA Hematopoietic Stem Cell Transplantation for Multiple Sclerosis Jingwu Zhang Zang, GlaxoSmithKline, China Optimizing Translational Research Pipelines in MS Douglas Goodin*
, University of California, San Francisco, USA
The Hitchhikers Guide to Therapeutic Choice Short Talk Chosen from Abstracts TUESDAY, JANUARY 15 Neurobiology Trevor J. Kilpatrick*, University of Melbourne, Australia Peter K. Stys, University of Calgary, Canada Axon-Glial Interactions Ben Emery, University of Melbourne, Australia Molecular Determinants of Myelination Catherine Lubetzki, INSERM and UPMC, France Translational Approaches to Remyelination Frauke Zipp, Johannes-Gutenberg-Universitt Mainz, Germany Crosstalk of the Immune System and the Nervous System Short Talk(s) Chosen from Abstracts Repair Catherine Lubetzki*, INSERM and UPMC, France Gianvito Martino San Raffaele Scientiic Institute Italy The Role of Neural Stem Cells in Brain Regeneration Trevor J. Kilpatrick, University of Melbourne, Australia Targeting the Oligodendrocyte Lineage Speaker to be Announced Short Talk Chosen from Abstracts WEDNESDAY, JANUARY 16: DEPARTURE *Session Chair
Invited, not yet accepted
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 12 NEW FRONTIERS IN CARDIOVASCULAR GENETICS BEYOND GWAS JANUARY 1318, 2013 GRANLIBAKKEN RESORT, TAHOE CITY, CALIFORNIA, USA (venue information on page 27) DEADLINES: ABSTRACT & SCHOLARSHIP SEP 12, 2012 LATE-BREAKING ABSTRACT OCT 11, 2012 DISCOUNTED REGISTRATION NOV 12, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13A2 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A2. Scientic Organizers: Jennifer Hall and Stephen S. Rich SUNDAY, JANUARY 13: ARRIVAL & REGISTRATION MONDAY, JANUARY 14 Keynote Address Eric D. Green, NHGRI, National Institutes of Health, USA Entering the Era of Genomic Medicine: Research Opportunities and Challenges Breakthroughs in Sequencing and New Approaches in Applications Jennifer Hall*, University of Minnesota, USA Stephen S. Rich*, University of Virginia, USA Richard Wilson
, Washington University School of Medicine, USA
New Approaches and Challenges in Sequencing Deborah A. Nickerson, University of Washington, USA The Next Steps in Sequencing Speaker to be Announced Short Talk(s) Chosen from Abstracts Integrating Brain and Heart John Hardy*, University College London, UK Genetic Basis of Alzheimers Disease and Ischemic Stroke Bruce D. Gelb, Mount Sinai Medical Center, USA Complex Genetic Networks in Cardiovascular Disease Rich Bonneau, New York University, USA Learning Dynamic Genome-Scale Models of Hematopoietic Stem Cell Differentiation and Function Short Talk Chosen from Abstracts TUESDAY, JANUARY 15 Genetics of Coronary Artery Disease Daniel J. Rader, University of Pennsylvania, USA Novel Biological Pathways and Therapeutic Targets for Atherosclerosis Tom Quertermous, Stanford University School of Medicine/ VIA Pharmaceuticals Inc., USA Mechanisms of Coronary Heart Disease Associated Genetic Risk Loci Kelly A. Frazer, University of California, San Diego, USA Identifying and Characterizing Risk Loci for Coronary Artery Disease Geoffrey S. Ginsburg*, Duke University, USA How Do Genetic/Genomic Tests Compete? Short Talk(s) Chosen from Abstracts Structural Variation Stephen S. Rich*, University of Virginia, USA Major Discoveries of Structural Variants on Risk of Human Disease Marcelo Nobrega, University of Chicago, USA Regulatory Networks in Heart Development and Heart Disease Evan E. Eichler, University of Washington, USA Structural Variation in the Human Genome Short Talk Chosen from Abstracts WEDNESDAY, JANUARY 16 State of the Art in Heart Failure (Bench to Bedside) Jennifer Hall*, University of Minnesota, USA SNPs in miRNA Binding Sites in a Cohort of Individuals with Heart Failure Stuart A. Cook, Imperial College London, UK New Approaches to Understanding Cardiomyopathy Helen H. Hobbs, University of Texas Southwestern Medical Center, USA Genomic Approaches to Lipids, Coronary Atherosclerosis and Metabolic Syndrome Speaker to be Announced Short Talk(s) Chosen from Abstracts The Genetics of Arrhythmias Emelia J. Benjamin*, Boston University, USA The Genetics of Atrial Fibrillation Calum A. MacRae, Brigham & Womens Hospital, USA High-Throughput in vivo Exploration of Disease Networks in ebraish Silvia G. Priori, Foundation Salvatore Maugeri, Italy Personalized Medicine Treatment and Genotyping for Long QT Syndrome: The Past, Present and Future Short Talk Chosen from Abstracts THURSDAY, JANUARY 17 Breakthroughs in Genomics and Personalized Medicine David R. Bentley, Illumina Cambridge Ltd, UK Genomes in Medicine Howard J. Jacob*, Medical College of Wisconsin, USA Whole Genome Sequencing: Just Another Clinical Lab Diagnostic? Nola Masterson, Science Futures Inc., USA What Is Next? Pierre Cassigneul, XDx Expression Diagnostics, USA Where Is the Field of Personalized Medicine in Heart Transplant? Short Talk(s) Chosen from Abstracts Dificulties in Going from Genotype to Phenotype Eric A. Boerwinkle*, University of Texas, USA Genotype to Phenotype with Hypertension: The Challenges Aravinda Chakravarti, Johns Hopkins University School of Medicine, USA From Genome to Function Nicole Soranzo, Wellcome Trust Sanger Institute, UK From Genome to Function Richard P. Lifton
, HHMI/Yale University School of Medicine, USA
Genomics of Personalized Medicine: The Challenges that Lie Ahead Short Talk Chosen from Abstracts FRIDAY, JANUARY 18: DEPARTURE *Session Chair
Invited, not yet accepted
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 13 FRONTIERS OF NMR IN BIOLOGY JANUARY 1318, 2013 SNOWBIRD RESORT, SNOWBIRD, UTAH, USA (venue information on page 27) Scientic Organizers: Gerhard Wagner, Angela M. Gronenborn and Marc Baldus DEADLINES: ABSTRACT & SCHOLARSHIP SEP 13, 2012 LATE-BREAKING ABSTRACT OCT 15, 2012 DISCOUNTED REGISTRATION NOV 13, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13A3 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A3. s SUNDAY, JANUARY 13: ARRIVAL & REGISTRATION MONDAY, JANUARY 14 Keynote Address Michael F. Summers, HHMI/University of Maryland Baltimore County, USA NMR Methods for Large RNAs and the Mechanism of HIV-1 Genome Packaging New Methods in Solid State NMR Beat H. Meier, ETH Zrich, Switzerland Amyloid Structures by Solid State NMR Tatyana Polenova, University of Delaware, USA Magic Angle Spinning Studies of HIV-1 Protein Assemblies Bernd Reif, Technische Universitt Mnchen, Germany Deuteration in and 1H Detection in Solid State NMR Chad M. Rienstra, University of Illinois at Urbana-Champaign, USA High-Resolution Protein Structures by Magic-Angle Spinning NMR Short Talk Chosen from Abstracts NMR in Cells and Cell Extracts Philipp Selenko, FMP Berlin, Germany Real-Time Characterization of Posttranslational Protein Modiications in Cellular Environments Masahiro Shirakawa, Kyoto University, Japan In-Cell NMR Spectroscopy of Proteins inside Living Cells Teresa Fan, University of Louisville, USA Metabolite Flux Measurements in Living Cells Short Talk Chosen from Abstracts TUESDAY, JANUARY 15 Elucidating Protein Structure and Function Kevin H. Gardner, University of Texas Southwestern Medical Center, USA Mechanisms of Hypoxic Gene Activation Mitsuhiko Ikura, Ontario Cancer Institute, Canada IP3 Receptor Binding and Channel Gating Angela M. Gronenborn, University of Pittsburgh, USA HIV Cellular Protein Interactions Katherine A. Henzler-Wildman, Washington University, USA Asymmetry and Exchange in the Mechanism of Multidrug Eflux by EmrE Short Talk(s) Chosen from Abstracts Workshop: Protein and RNA Production and Labeling Nucleotides and Nucleotide/Protein Complexes Juli Feigon, University of California, Los Angeles, USA The Architecture of Telomerase Walter J. Chazin, Vanderbilt University, USA Structure and Dynamics of Integrated DNA Replication, Damage Response and Repair Machinery Michael J. Sattler, Technical University Munich and German Research Center for Environmental Health, Germany Protein-Nucleic Acid Interactions in Splicing Short Talk Chosen from Abstracts WEDNESDAY, JANUARY 16 Membrane Proteins James Jeiwen Chou, Harvard Medical School, USA Structure and Mechanism of Mitochondrial Carriers Linda Columbus, University of Virginia, USA Structure, Folding and Functional Studies of Opacity-Associated (Opa Proteins from Neisseria gonorrhoeae Marc Baldus, Utrecht University, Netherlands Characterization of Membrane Proteins in the Solid State Senyon Choe, The Salk Institute, USA Facile NMR Structure Determination of Human Membrane Proteins Short Talk(s) Chosen from Abstracts Drug Targets, NMR in Industry Stephen W. Fesik, Vanderbilt University School of Medicine, USA NMR-Based Drug Discovery in Academia Daniel F. Wyss, Merck & Co., Inc., USA FBDD on a Tough Target Starts to Yield Discovery of Orally Active, Brain-Penetrant BACE1 Inhibitors Teresa Carlomagno, EMBL Heidelberg, Germany NMR-Based Drug Discovery Methods in Academia Short Talk Chosen from Abstracts THURSDAY, JANUARY 17 Solution NMR Methods Ad Bax, NIDDK, National Institutes of Health, USA Structures from Chemical Shifts and Databases Gerhard Wagner, Harvard Medical School, USA New NMR Experiments for Challenging Proteins Gottfried Otting, Australian National University, Australia Paramagnetic Probes for NMR Studies Bernhard Brutscher, Institut de Biologie Structurale, France Fast Methods in Biological NMR Short Talk(s) Chosen from Abstracts Folding and Disease David Baker
, University of Washington, USA
Folding Proteins from Sparse NMR Data Robert Tycko, National Institutes of Health, USA Amyloid Fibril Structures, in vitro and in vivo Christopher M. Dobson
, University of Cambridge, UK Unfolded States, Misfolding and Disease FRIDAY, JANUARY 18: DEPARTURE
Invited, not yet accepted
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 14 HEMATOPOIESIS JANUARY 1419, 2013 SHERATON RESORT STEAMBOAT, STEAMBOAT SPRINGS, COLORADO, USA (venue information on page 27) DEADLINES: ABSTRACT & SCHOLARSHIP SEP 13, 2012 LATE-BREAKING ABSTRACT OCT 16, 2012 DISCOUNTED REGISTRATION NOV 13, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13A4 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A4. Scientic Organizers: Leonard I. Zon, Stuart H. Orkin and Nancy A. Speck Sponsored by Celgene Corporation MONDAY, JANUARY 14: ARRIVAL & REGISTRATION TUESDAY, JANUARY 15 Developmental Hematopoiesis Including ES and iPS to Blood Catherine Porcher, University of Oxford, UK The SCL Complex and Hematopoiesis Nancy A. Speck, University of Pennsylvania, USA Hematopoietic Commitment Mediated by Runx1 Elaine A. Dzierzak, Erasmus University, Netherlands The Developmental Origins of Adult HSCs Gordon M. Keller, University Health Network, MaRS Centre, Canada Multiple Waves of Hemogenic Endothelium from ES Cells Short Talk(s) Chosen from Abstracts Workshop 1: Stem Cell Self-Renewal Short Talks Chosen from Abstracts Novel Hematopoietic Regulators Leonard I. Zon, HHMI/Childrens Hospital Boston, USA Pathways Regulating Blood Stem Cell Self-Renewal and Engraftment David Traver, University of California, San Diego, USA Novel Signals Controlling Stem Cell Development in ebraish Sean J. Morrison, HHMI/University of Texas Southwestern Medical Center, USA Metabolism and Stem Cells Short Talk Chosen from Abstracts Keynote Address George Q. Daley, Childrens Hospital Boston, USA Milestones and Barriers in HSC Production from ES or iPS Cells WEDNESDAY, JANUARY 16 Adult Stem Cell Self-Renewal and Function Emmanuelle Passegu, University of California, San Francisco, USA Self-Renewal and DNA Repair Amy J. Wagers, Harvard University, USA Local and Systemic Regulation of Blood Stem Cell Function throughout Life Margaret A. Goodell, Baylor College of Medicine, USA HSCs during Stress and Host Defense Daniel G. Tenen, Harvard Stem Cell Institute, Boston, USA and Cancer Science Institute, Singapore Regulation of Myeloid Transcription Factors and Methylation by Long Noncoding Intragenic RNAs Short Talk(s) Chosen from Abstracts Microenvironment David T. Scadden, Massachusetts General Hospital and Harvard University, USA Function of the Niche in Self-Renewal of HSCs Toshio Suda, Keio University, Japan A Metabolic Guide to Stem Cell Homeostasis Michael P. Cooke, Genomics Institute of the Novartis Research Foundation, USA Regulation of HSC Self-Renewal by the Aryl Hydrocarbon Receptor Short Talk Chosen from Abstracts THURSDAY, JANUARY 17 Erythroid and Megakaryocyte Development Stuart H. Orkin, Dana-Farber Cancer Institute, USA Regulation of Globin Gene Switching Mitchell J. Weiss, Childrens Hospital of Philadelphia, USA Erythroid and Megakaryocytic Gene Expression and miRNAs Harvey Lodish, Whitehead Institute for Biomedical Research, USA The Terminal Stages of Red Cell Development Hanna K. A. Mikkola, University of California, Los Angeles, USA Speciication and Self-Renewal of Hematopoietic Stem Cells Short Talk(s) Chosen from Abstracts Workshop 2: Differentiation of Hematopoietic Cells Short Talks Chosen from Abstracts Hematopoietic Cell Differentiation and Function Bertie Gottgens, Cambridge Institute for Medical Research, UK Combinatorial Control of Lineage Commitment Meinrad Busslinger, Research Institute of Molecular Pathology, Austria Transcriptional Control of Early Lymphopoiesis Irving L. Weissman, Stanford University, USA Myeloid Cells and Dont Eat Me Signal Short Talk Chosen from Abstracts FRIDAY, JANUARY 18 Leukemogenesis Ross L. Levine, Memorial Sloan-Kettering Cancer Center, USA Role of Mutations in Epigenetic Modiiers in Myeloid Malignancies Scott A. Armstrong, Childrens Hospital Boston, USA Molecular Characterization of Leukemia Stem Cell Self-Renewal John E. Dick, Toronto General Research Institute, University Health Network, Canada Toward Uniication of the Genetic and Cancer Stem Cell Models of Leukemia Anjana Rao, La Jolla Institute for Allergy and Immunology, USA Modiication of DNA Cytosine Methylation by TET Proteins Short Talk(s) Chosen from Abstracts Lymphoid Avinash S. Bhandoola, University of Pennsylvania, USA Establishing T Cell Identity Sten Erik W. Jacobsen, University of Oxford, UK Origin of Lymphoid Lineages Ellen Rothenberg, California Institute of Technology, USA Sequential Operation of Gene Regulatory Networks in the Stem Cell to T Cell Commitment Process Short Talk Chosen from Abstracts SATURDAY, JANUARY 19: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 15 EMERGING TOPICS IN IMMUNE SYSTEM PLASTICITY: CELLULAR NETWORKS, METABOLIC CONTROL AND REGENERATION JANUARY 1520, 2013 SANTA FE COMMUNITY CONVENTION CENTER, SANTA FE, NEW MEXICO, USA (venue information on page 21) Scientic Organizers: Steven L. Reiner, Erika L. Pearce and Yasmine Belkaid DEADLINES: ABSTRACT & SCHOLARSHIP SEP 18, 2012 LATE-BREAKING ABSTRACT OCT 17, 2012 DISCOUNTED REGISTRATION NOV 14, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster session or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13A5. Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A5. TUESDAY, JANUARY 15: ARRIVAL & REGISTRATION WEDNESDAY, JANUARY 16 Keynote Address Ruslan M. Medzhitov, Yale University School of Medicine, USA Signals, Noise and Cell Decisions Novel Innate and Adaptive Cell Types Luke A. J. ONeill, Trinity College Dublin, Ireland Signaling Innate Immunity and Inlammation Brigitta Stockinger, MRC National Institute for Medical Research, UK Th17 Variants David Artis, University of Pennsylvania, School of Medicine, USA Innate Lymphocytes in Barrier Immunity Metabolic Regulation of the Immune Response Erika L. Pearce, Washington University School of Medicine, USA Metabolism and the Fate of CD8+ T Cells Douglas R. Green, St. Jude Childrens Research Hospital, USA Central Metabolic Mechanisms in Cancer and the Immune System Short Talks Chosen from Abstracts THURSDAY, JANUARY 17 Targeted Control of Immune Responses Yasmine Belkaid, NIAID, National Institutes of Health, USA Immune Regulation in the Intestine Alexander Y. Rudensky, Memorial Sloan-Kettering Cancer Center, USA Molecular Control of Regulatory T Cell Plasticity Akiko Iwasaki, Yale University School of Medicine, USA Cellular Control of Barrier Immunity John J. OShea, NIAMS, National Institutes of Health, USA Therapeutic Application of Jak/Stat Inhibition Orchestrating Humoral Immunity Jason G. Cyster, University of California, San Francisco, USA Germinal Center Dynamics Kenneth M. Murphy, Washington University School of Medicine, USA Coordinating Transcriptional Control of T Cells and B Cells Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland Human B Cell Memory FRIDAY, JANUARY 18 Host-Microbe Interface in the Immune Response Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA Inlammation and Infectious Diseases Short Talks Chosen from Abstracts Aviv Regev, Massachusetts Institute of Technology, USA Biological Networks in Development and Immunity Julie Magarian Blander, Mount Sinai School of Medicine, USA Vita-PAMPs: Signatures of Microbial Viability Plasticity of the Microenvironment Marc Veldhoen, Babraham Institute, UK Aryl Hydrocarbon Receptors as Interpreters and Defenders of Barrier Integrity Shannon J. Turley, Dana-Farber Cancer Institute, Harvard Medical School, USA Immunological Hallmarks of Inlamed Stroma Speaker to be Announced Cutting-Edge Talk on Tumor Microenvironment SATURDAY, JANUARY 19 Cell Fate Speciication of Lymphocytes Short Talks Chosen from Abstracts Amy J. Wagers, Harvard University, USA Maintenance and Renewal of Tissue-Speciic Stem Cells Steven L. Reiner, Columbia University, USA Generating Cellular Diversity through Asymmetric Division Alexander (Sasha) Tarakhovsky, Rockefeller University, USA Regulation of Cell Identity by Histone Methylation Network Analysis across Evolution Eric H. Davidson, California Institute of Technology, USA Evolution of Gene Networks Controlling Development Keynote Address Elaine Fuchs, HHMI/Rockefeller University, USA Crosstalk between Stem Cells and their Microenvironment SUNDAY, JANUARY 20: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 16 PLANT ABIOTIC STRESS AND SUSTAINABLE AGRICULTURE: TRANSLATING BASIC UNDERSTANDING TO FOOD PRODUCTION JANUARY 1722, 2013 SAGEBRUSH INN & CONFERENCE CENTER, TAOS, NEW MEXICO, USA (venue information on page 27) DEADLINES: ABSTRACT & SCHOLARSHIP SEP 19, 2012 LATE-BREAKING ABSTRACT OCT 18, 2012 DISCOUNTED REGISTRATION NOV 14, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13A6 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A6. Scientic Organizers: Julia Bailey-Serres and Paul Michael Hasegawa Sponsored by Monsanto Company THURSDAY, JANUARY 17: ARRIVAL & REGISTRATION FRIDAY, JANUARY 18 Keynote Address Marc Van Montagu, Ghent University, Belgium Embracing Global Challenges in Agriculture Harnessing Genetic Diversity to Improve Crop Stress Tolerance Mark Tester, University of Adelaide, Australia Harnessing Diversity for Salt and Drought Tolerance in Cereals Julia Bailey-Serres, University of California, Riverside, USA Mechanisms of Flooding Tolerance in Rice Sigrid Heuer, International Rice Research Institute, Philippines Molecular Breeding and Genes for Rice with Low-Phosphorus Tolerance Short Talks Chosen from Abstracts Extremes in Water Availability: From Genes to Field Rens Voesenek, Utrecht University, Netherlands Submergence Coping Mechanisms in Wild Species Kazuo Shinozaki, RIKEN Plant Science Center, Japan Omics of Abiotic Stresses: Networks and Responses Michael L. Nuccio, Syngenta Biotechnology, Inc., USA Improvement of Drought Tolerance in Crops Short Talk Chosen from Abstracts SATURDAY, JANUARY 19 Understanding and Improving Water Use Eficiency Michael V. Mickelbart, Purdue University, USA Mechanisms Underlying Water Use Eficiency Alistair Hetherington, University of Bristol, UK Environmental Regulation of Stomatal Dynamics Dominique Bergmann, Stanford University, USA Regulation of Stomatal Development and Performance in Reference Monocot and Dicot Species Short Talks Chosen from Abstracts Stress Sensing, Signaling and Response Networks Sean Cutler, University of California, Riverside, USA Structure and Function of ABA Receptors Jian-Kang Zhu, Purdue University, USA Osmotic Stress Sensing and Signaling in Arabidopsis Ron Mittler, University of North Texas, USA Dissecting the Rapid Systemic Signaling Pathway of Plants Short Talk Chosen from Abstracts SUNDAY, JANUARY 20 Roots and their Environment Luis Herrera-Estrella, Cinvestav, Mexico Root Architecture Remodeling for Nutrient Acquisition Leon V. Kochian, Cornell University, USA How Do Plants Tolerate Toxic Metals in the Soil? Aluminum Tolerance as an Example Mary Lou Guerinot, Dartmouth College, USA From the Soil to the Seed: Metal Homeostasis in Plants Maria J. Harrison, Boyce Thompson Institute for Plant Research, USA Interrelationship between Plant Phosphate Acquisition and Mycorrhizae Stress Systems Biology to Genetic Variation Jerzy Paszkowski, University of Geneva, Switzerland Epigenetics Regulation of Abiotic Stress Responses Philip N. Benfey, Duke University, USA Systems Integrating Root Development and Environmental Cues Dirk Inz, Ghent University-VIB, Belgium Impact of Stress on Growth and Development Short Talk Chosen from Abstracts MONDAY, JANUARY 21 Challenges and Solutions in the Field Donald E. Nelson, Monsanto Company, USA Advances in Engineering Abiotic Tolerance in Key Crops Mitch R. Tuinstra, Purdue University, USA Prospects for Adapting Maize to Drought and High-Temperature Stresses Richard James, CSIRO, Australia Development and Evaluation of Salt-Tolerant Wheat Short Talks Chosen from Abstracts Global Climate Change: CO 2 and Temperature Philip Wigge, John Innes Centre, UK Temperature Sensing Pathways in Plants Lisa Ainsworth, USDA ARS, University of Illinois at Urbana-Champaign, USA Maximizing Soybean Production in a High CO 2 World Susan von Caemmerer, Australian National University, Australia Impacts of Elevated CO 2 on Photosynthesis and Other Processes Short Talk Chosen from Abstracts TUESDAY, JANUARY 22: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 17 NONCODING RNAS IN DEVELOPMENT AND CANCER JANUARY 2025, 2013 FAIRMONT HOTEL VANCOUVER, VANCOUVER, BRITISH COLUMBIA, CANADA (venue information on page 21) DEADLINES: ABSTRACT & SCHOLARSHIP SEP 20, 2012 LATE-BREAKING ABSTRACT OCT 22, 2012 DISCOUNTED REGISTRATION NOV 15, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster session or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13A7 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A7. Scientic Organizers: Joshua T. Mendell, Phillip A. Sharp, Judy Lieberman and Howard Y. Chang Sponsored by Isis Pharmaceuticals, Inc. SUNDAY, JANUARY 20: ARRIVAL & REGISTRATION Keynote Session Jeannie T. Lee, Massachusetts General Hospital, USA X-Chromosome Inactivation as a Model for Regulation by Long Noncoding RNA V. Narry Kim, Seoul National University, South Korea miRNA Processing and Mechanism MONDAY, JANUARY 21 MicroRNAs in Development Victor R. Ambros, University of Massachusetts, USA miRNAs in Developmental Timing Antonio J. Giraldez, Yale University, School of Medicine, USA miRNAs in ebraish Development Eric N. Olson, University of Texas Southwestern Medical Center, USA miRNAs in Cardiac Development and Disease Andrea Ventura, Memorial Sloan-Kettering Cancer Center, USA miRNAs in Mammalian Development and Disease Short Talk(s) Chosen from Abstracts Mechanisms of Small RNA Functions Phillip A. Sharp, Massachusetts Institute of Technology, USA Regulation and Function of Small RNA Pathways Judy Lieberman, Immune Disease Institute, USA A Systems Approach to Understanding Gene Networks Regulated by Oncomirs Irene Bozzoni, University La Sapienza, Rome, Italy Regulation of miRNA Function by Competing Endogenous RNAs Short Talk Chosen from Abstracts TUESDAY, JANUARY 22 Long Noncoding RNAs in Development Peter Fraser, Babraham Institute, UK LncRNA and Higher-Order Chromatin and Chromosome Structure Caroline Dean, John Innes Centre, UK LncRNAs and Flowering Control in Plants Genevive Almouzni, Centre National ue la Recheiche Scientiique Fiance LncRNA and Centrometric Heterochromatin Kathrin Plath, University of California, Los Angeles, USA X Inactivation and Reactivation in Induced Pluripotency Short Talk(s) Chosen from Abstracts Small RNAs in Pluripotent Cells Gregory J. Hannon, Cold Spring Harbor Laboratory, USA Talk Title to be Determined Robert H. Blelloch, University of California, San Francisco, USA Small RNA Regulation of Pluripotency George Q. Daley, Childrens Hospital Boston, USA Lin28 in Development and Disease Short Talk Chosen from Abstracts WEDNESDAY, JANUARY 23 MicroRNAs in Cancer Tyler Jacks, Massachusetts Institute of Technology, USA miRNA Expression and Function in Cancer Joshua T. Mendell, University of Texas Southwestern Medical Center, USA miRNAs in Cancer Signaling Pathways Frank J. Slack, Yale University, USA miRNAs as Oncogenes and Tumor Suppressors Chang-Zheng Chen, Stanford University, USA miRNAs in Lymphocytes and Leukemias Short Talk(s) Chosen from Abstracts Workshop: Therapeutic Applications of Noncoding RNAs Sakari Kauppinen, Santaris Pharma A/S, Denmark LNA-Based Anti-miRNA Therapeutics Eric G. Marcusson, Regulus Therapeutics, USA Discovery and Development of Anti-miRNA Therapeutics Andreas G. Bader, Mirna Therapeutics Inc., USA miRNA Replacement Therapy Eva van Rooij, miRagen Therapeutics, USA Targeting miRNAs in Cardiovascular Disease Processing of Noncoding RNAs Manel Esteller, IDIBELL, Spain Mechanisms of Altered miRNA Processing in Cancer Richard Iain Gregory, Harvard Medical School, Childrens Hospital, USA Regulation of miRNA Processing by Lin28 Alexei A. Aravin, California Institute of Technology, USA Regulation of piRNA Processing Short Talk Chosen from Abstracts THURSDAY, JANUARY 24 Long Noncoding RNAs in Cancer Howard Y. Chang, Stanford University, USA Long Noncoding RNAs and Cancer Progression Arul M. Chinnaiyan, University of Michigan, USA LncRNAs Discovery and Use as Noninvasive Biomarkers in Prostate Cancer John S. Mattick, Garvan Institute of Medical Research, Australia The Role of Regulatory RNA in Human Development Michael G. Rosenfeld, HHMI/University of California, San Diego, USA Moving Stories about lncRNA Short Talk(s) Chosen from Abstracts ncRNAs in Transcriptional Control and Chromatin Antonin Morillon, Institut Curie, France Yeast Cryptic ncRNAs and Chromatin Regulation Gary Felsenfeld, NIDDK, National Institutes of Health, USA ncRNA and Organization of Chromatin Domains Shiv I. S. Grewal, NCI, National Institutes of Health, USA The RNAi Pathway in Chromatin Regulation Short Talk Chosen from Abstracts FRIDAY, JANUARY 25: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 18 MALARIA JANUARY 2025, 2013 JW MARRIOTT NEW ORLEANS, NEW ORLEANS, LOUISIANA, USA (venue information on page 27) Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A8. Scientic Organizers: Fidel P. Zavala, Andrew P. Waters, Kevin Marsh and Carolina V. Barillas-Mury Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation Additional support from Medicines for Malaria Venture Ian Bathurst Global Health Travel Awards SUNDAY, JANUARY 20: ARRIVAL & REGISTRATION MONDAY, JANUARY 21 Keynote Address Alan Cowman, Walter and Eliza Hall Institute of Medical Research, Australia Mechanisms of Merozoite Invasion of Erythrocytes Understanding Protective Immunity Against Plasmodium Kevin Marsh, Kenya Medical Research Institute/Wellcome Trust Research Program, Kenya Immune Responses to Malaria in Endemic Areas Susan K. Pierce, NIAID, National Institutes of Health, USA Antibody Responses and Development of B-Cell Memory, or Lack of It Jean Langhorne, National Institute for Medical Research, UK CD4 T Cells as Regulators and Effectors in the Immune Response to Malaria William R. Heath, University of Melbourne, Australia Innate Immune Responses: Role of Dendritic Cells in Protection and Pathogenesis Fidel P. Zavala, Johns Hopkins Bloomberg School of Public Health, USA Effector Liver-Resident CD8+ T Cells New Approaches to Vaccination Robert Sauerwein, Radboud University, Netherlands Experimental Vaccination of Humans with Sporozites Simon J. Draper, University of Oxford, UK Combinatorial Vaccines Against Blood Stages Sarah Reece, University of Edinburgh, UK The Private Life of Parasites: Implications for Blocking Transmission Short Talk Chosen from Abstracts TUESDAY, JANUARY 22 Cellular and Molecular Biology of Plasmodium Robert Mnard, Institut Pasteur, France Molecular Basis of Plasmodium zoite Invasion into Host Cells Volker Heussler, Institute of Cell Biology, Switzerland Biology of Plasmodium Liver Stage Maria M. Mota, Instituto de Medicina Molecular, Portugal Development of Malaria Liver Stages Manoj Duraisingh, Harvard School of Public Health, USA Parasite Invasion in Genetically Modiied Erythrocytes Short Talk(s) Chosen from Abstracts Integrating Genomic Science and Population Biology Speaker to be Announced Gilean McVean, University of Oxford, UK Using de novo Assembly to Track Hypervariable Genes in Malaria Parasites Michael T. Ferdig, Notre Dame University, USA How Does the Parasite Fight Back? Short Talk Chosen from Abstracts WEDNESDAY, JANUARY 23 Vector Biology and Malaria Transmission Carolina V. Barillas-Mury, NIAID, National Institutes of Health, USA Biology of Vector-Parasite Interactions George Dimopoulos, Johns Hopkins University, USA Anopheles Functional Genomics Flaminia Catteruccia, Harvard School of Public Health, USA Reproductive Biology of Anopheles Mosquitoes and Malaria Transmission Luciano Andrade Moreira, Instituto de Pesquisas Ren Rachou-Fiocruz, Brazil Use of Wolbachia for Control of Vector-Borne Diseases Short Talk(s) Chosen from Abstracts Biology of Plasmodium Transmission Stages Andrew P. Waters, University of Glasgow, UK RNA Biology and Zygote Development Oliver Billker, Wellcome Trust Sanger Institute, UK Signaling and Zygote Development Jake Baum, Walter and Eliza Hall Institute of Medical Research, Australia Cell Motility and Parasite Transmission Short Talk Chosen from Abstracts THURSDAY, JANUARY 24 Epidemiology and Pathogenesis of Severe Malaria Emelda Okiro, Kenya Medical Research Institute/Wellcome Trust Research Programme, Kenya Epidemiology and Populational Aspects of Severe Disease Terrie E. Taylor, Michigan State University, USA Current Understanding of Pathogenesis of Severe Malaria in Humans Christian Engwerda Queenslanu Institute of Neuical Reseaich Austialia Mechanisms of Pathogenesis in Experimental Models Dominic Kwiatkowski, Oxford University and Wellcome Trust Sanger Institute, UK Genetics of Disease Susceptibility Short Talk(s) Chosen from Abstracts Mechanisms of Drug Resistance David A. Fidock, Columbia University, USA Cellular and Molecular Basis of Drug Resistance Dyann F. Wirth, Harvard University, USA Genetics Analysis of Drug Resistance Xin-Zhuan Su, NIAID, National Institutes of Health, USA Whole Genome Approaches to Identify Drugs that Work and Why Others Dont Short Talk Chosen from Abstracts FRIDAY, JANUARY 25: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. DEADLINES: GLOBAL HEALTH TRAVEL AWARD AUG 21, 2012 ABSTRACT & SCHOLARSHIP SEP 20, 2012 LATE-BREAKING ABSTRACT OCT 23, 2012 DISCOUNTED REGISTRATION NOV 15, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13A8 19 METABOLIC CONTROL OF INFLAMMATION AND IMMUNITY JANUARY 2126, 2013 BEAVER RUN RESORT, BRECKENRIDGE, COLORADO, USA (venue information on page 27) DEADLINES: ABSTRACT & SCHOLARSHIP SEP 24, 2012 LATE-BREAKING ABSTRACT OCT 24, 2012 DISCOUNTED REGISTRATION NOV 19, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13A9 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13A9. Scientic Organizers: Vishva M. Dixit, Douglas R. Green and Maya Saleh MONDAY, JANUARY 21: ARRIVAL & REGISTRATION TUESDAY, JANUARY 22 Keynote Address Richard A. Flavell, Yale University School of Medicine, USA Microbiota, NLRs and the Inlammasome Metabolism and Signaling Ronald M. Evans, The Salk Institute, USA PPAR and Circadian Rhythm Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA Talk Title to be Determined Ajay Chawla, University of California, San Francisco, USA Innate Control of Metabolism Mitchell A. Lazar, University of Pennsylvania School of Medicine, USA PPARs, Diabetes and Inlammation The Inlammasome and Metabolism I Vishva M. Dixit, Genentech, Inc., USA New Components: Caspase-11 and Beyond Jenny P. Ting, University of North Carolina at Chapel Hill, USA Fatty Acid-Induced NLRP3 Inlammasome Activation Thirumala-Devi Kanneganti, St. Jude Childrens Research Hospital, USA Nlrp3 Inlammasome in Diabetes Eicke Latz, University of Massachusetts Medical School, USA The Inlammasome in Atherosclerosis WEDNESDAY, JANUARY 23 The Inlammasome and Metabolism II Charles A. Dinarello, University of Colorado Health Sciences Center, USA How Does the IL-1 Family Control its Own Members? Luke A. J. ONeill, Trinity College Dublin, Ireland Metabolic Control of IL-1b Signaling Marc Y. Donath, University Hospital Basel, Switzerland IL-1b and Diabetes Vishwa Deep Dixit, Pennington Biomedical Research Center, LSU System, USA The NLRP3 Inlammasome and Obesity-Associated Co-Morbidities Inlammation and Metabolism Gkhan S. Hotamisligil, Harvard University, USA Metabolism, ER Stress and Inlammation Speaker to be Announced Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA Targeting Inlammation in Insulin Resistance and Diabetes THURSDAY, JANUARY 24 NOD, Microbiota and Metabolism Maya Saleh, McGill University, Canada NOD-Mediated Inlammation Stephen E. Girardin, University of Toronto, Canada NOD2, Autophagy and Inlammation Herbert (Skip) W. Virgin IV, Washington University School of Medicine, USA Autophagy in Inlammation and Disease Gabriel Nuez, University of Michigan, USA Inlammasome Inluence on Microbiota Mitochondria, Inlammation and Metabolism Kate A. Fitzgerald, University of Massachusetts Medical School, USA Cytosolic Immune Surveillance Speaker to be Announced Richard M. Siegel, NIAMS, National Institutes of Health, USA Mitochondrial ROS: Fuel for the Fire of Autoinlammation FRIDAY, JANUARY 25 Metabolic Control of Adaptive Immunity Drew M. Pardoll, Johns Hopkins University School of Medicine, USA HIF1 in the Treg/Th17 Axis Jonathan D. Powell, Johns Hopkins University School of Medicine, USA mTOR Regulation of T Cell Function Douglas R. Green, St. Jude Childrens Research Hospital, USA Metabolic Reprogramming in Activated T Cells Jeffrey C. Rathmell, Duke University, USA Glucose Metabolism in T Cell Activation and CD4 Subsets Cell Death, Immunity and Metabolism Michael Karin, University of California, San Diego, USA NF-B, Inlammation and Metabolism Kodi S. Ravichandran, University of Virginia, USA Apoptotic Cell Clearance and the Phagocyte Metabolism Nika N. Danial, Dana-Farber Cancer Institute, USA A Role for Bcl2 Family Members in Diabetes SATURDAY, JANUARY 26: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 20 PORTOLA HOTEL & SPA MONTEREY, CALIFORNIA, USA Local elevation: 40 (12 m) Local airports/distances to venue: Monterey Penninsula (MRY)/4 mi (6 km); San Jose International (SJC)/74 mi (119 km) SHERATON MIYAKO HOTEL TOKYO TOKYO, JAPAN Local elevation: 59 (18 m) Local airports/distances to venue: Narita International (NRT)/49 mi (79 km); Tokyo International/Haneda (HND)/8 mi (13 km) FAIRMONT CHTEAU LAURIER OTTAWA, ONTARIO, CANADA SANTA FE COMMUNITY CONVENTION CENTER SANTA FE, NEW MEXICO, USA BIG SKY RESORT BIG SKY, MONTANA, USA Local elevation: 50 (18 m) Local airport/distance to venue: Ottawa MacDonald-Cartier (YOW)/9 mi (15 km) Local elevation: 7000 (2134 m) Local airports/distances to venue: Albuquerque International Sunport ABQ mi km Santa Fe Nunicipal SAF mi km Local elevation: 7500 (2286 m) Local airport/distance to venue: Bozeman Gallatin Field (BZN)/ 49 mi (79 km) FAIRMONT HOTEL VANCOUVER VANCOUVER, BRITISH COLUMBIA, CANADA Local elevation: 108 (33 m) Local airport/distance to venue: Vancouver International (YVR)/9 mi (14 km) 21 ANTIBODIES AS DRUGS JANUARY 27FEBRUARY 1, 2013 FAIRMONT HOTEL VANCOUVER, VANCOUVER, BRITISH COLUMBIA, CANADA (venue information on page 21) Scientic Organizers: Paul Carter and Andreas G. Plckthun Sponsored by Abbott Laboratories and Astellas Pharma Inc. Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J3. JOINT WITH... SUNDAY, JANUARY 27: ARRIVAL & REGISTRATION Keynote Address Jeffrey V. Ravetch, Rockefeller University, USA Remodeling Antibody Glycans for Immunomodulation MONDAY, JANUARY 28 Tumor Targeting From Understanding Mechanisms to New Targeting Agents (Joint) Karl Dane Wittrup, Massachusetts Institute of Technology, USA Synergistic Antibody and Cytokine Effects in Cancer Immunotherapy Kerry Chester, University College London Cancer Institute, UK Antibody-Targeted Iron Oxide Nanoparticles for Cancer Dario Neri, ETH Zrich, Switzerland Armed Antibodies for Vascular Targeting Anna M. Wu, University of California, Los Angeles, USA Engineered Antibodies for Molecular Imaging of Cancer Short Talk(s) Chosen from Abstracts Workshop 1: Emerging Antibody Generation Methods Short Talks Chosen from Abstracts Payloaded Antibodies for Cancer Treatment Peter D. Senter, Seattle Genetics Inc., USA Antibody-Drug Conjugates with Auristatins: From ADC Optimization to a Clinically Approved Drug and Beyond John M. Lambert, ImmunoGen, Inc., USA Antibody-Drug Conjugates with Maytansinoids Paul G. Polakis, Genentech, Inc., USA Target Selection for Antibody-Drug Conjugates Short Talk Chosen from Abstracts TUESDAY, JANUARY 29 Antibodies in Infectious Diseases Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland Human Antibodies to Infectious Disease Targets Dennis R. Burton, The Scripps Research Institute, USA HIV Reverse Vaccinology Gary J. Nabel, NIAID, National Institutes of Health, USA Broadly Neutralizing Antibodies to HIV Erica Ollmann Saphire, The Scripps Research Institute, USA Antibodies Against Ebola Short Talk(s) Chosen from Abstracts New Technologies for Generating Proteins with Novel Functions David Baker, University of Washington, USA Computational Design/Redesign of Proteins Speaker to be Announced Julia Shifman, Hebrew University of Jerusalem, Israel Computational Design of Protein-Protein Interactions Short Talk Chosen from Abstracts WEDNESDAY, JANUARY 30 Bispeciic and Multispeciic Targeting Agents Carlos F. Barbas III, The Scripps Research Institute, USA Multifunctional and Multispeciic Antibodies: New Strategies and Activities Kaspar H. Binz, Molecular Partners, Switzerland Exploiting Novel Therapeutic Mechanisms Using Multi-Speciic DARPins James D. Marks, University of California, San Francisco, USA Antibody Combinations for Treatment of Botulism Lutz Jermutus, MedImmune Ltd, UK Bispeciic Antibodies from Phenotypic Selections Targeting Pseudomonas aeruginosa Short Talk(s) Chosen from Abstracts Workshop 2: Enhancing Effector Functions and Extending Half-Life Short Talks Chosen from Abstracts Modulating the Activity of Growth Factor Receptors Andreas G. Plckthun, University of Zurich, Switzerland New Approaches to Receptor Antagonism Ermanno Gherardi
, Medical Research Council Laboratory
of Molecular Biology, UK Met Biology and Structural Biochemistry Thi-Sau Migone, Human Genome Sciences, USA Belimumab A Human MAb Against BLys for the Treatment of SLE Short Talk Chosen from Abstracts THURSDAY, JANUARY 31 Immunmodulatory Antibody Therapies (Joint) Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA PD-1 Blockade in Cancer Therapy Nils Lonberg, Bristol-Myers Squibb, USA Development Hurdles for Immuno-Oncology Antibody Drugs Patrick A. Baeuerle, Micromet GmbH, Germany Cancer Therapy by Bispeciic, T Cell-Engaging Antibodies Speaker to be Announced Challenges and New Opportunities with Antibody Drugs Ryan J. Watts, Genentech, Inc., USA Bispeciic Antibodies to Deliver Therapeutics across the Blood-Brain Barrier Leo James, University of Cambridge, UK Intracellular Immunity and TRIM21 Erkki Ruoslahti, Sanford-Burnham Medical Research Institute, USA Increasing Extravasation with Peptides Short Talk Chosen from Abstracts FRIDAY, FEBRUARY 1: DEPARTURE
Invited, not yet accepted
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 22 CANCER IMMUNOLOGY AND IMMUNOTHERAPY Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J4. DEADLINES FOR BOTH CONFERENCES: ABSTRACT & SCHOLARSHIP SEP 25, 2012 LATE-BREAKING ABSTRACT OCT 25, 2012 DISCOUNTED REGISTRATION NOV 27, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13J3 or /13J4 Scientic Organizers: Glenn Dranoff, Carl H. June and Suzanne L. Topalian Sponsored by Bayer USA Foundation Registering for one conference in a set of joint conferences enables participation in sessions of the other, pending space availability. SUNDAY, JANUARY 27: ARRIVAL & REGISTRATION Keynote Address James P. Allison, Memorial Sloan-Kettering Cancer Center, USA Checkpoint Blockade MONDAY, JANUARY 28 Tumor Targeting From Understanding Mechanisms to New Targeting Agents (Joint) Karl Dane Wittrup, Massachusetts Institute of Technology, USA Synergistic Antibody and Cytokine Effects in Cancer Immunotherapy Kerry Chester, University College London Cancer Institute, UK Antibody-Targeting Iron Oxide Nanoparticles from Cancer Dario Neri, ETH Zrich, Switzerland Armed Antibodies for Vascular Targeting Anna M. Wu, University of California, Los Angeles, USA Engineered Antibodies for Molecular Imaging of Cancer Short Talk(s) Chosen from Abstracts Tumor Microenvironment Wolf-Herman Fridman, Hpital Europen Georges-Pompidou, France The Immune Microenvironment of Primary and Metastatic Human Tumors Robert D. Schreiber, Washington University School of Medicine, USA Cancer Immunoediting Mechanisms and Therapeutic Opportunities Drew M. Pardoll, Johns Hopkins University School of Medicine, USA Inlammation and Cancer Short Talk Chosen from Abstracts TUESDAY, JANUARY 29 Engineering and Immunotherapy David J. Mooney, Harvard University, USA Polymer Scaffolds for Immunotherapy Darrell J. Irvine, Massachusetts Institute of Technology, USA Nanoparticles for Cellular Therapy Carl H. June, University of Pennsylvania, USA Engineered T Cells for Adoptive Therapy Laurence J.N. Cooper, University of Texas MD Anderson Cancer Center, USA Sleeping Beauty Transposase for Engineered T Cells Short Talk(s) Chosen from Abstracts Cancer Vaccines Cornelis J. M. Melief, Leiden University Medical Center, Netherlands Long Peptides Cornelia L. Trimble, Johns Hopkins University School of Medicine, USA Talk Title to be Determined Speaker to be Announced Short Talk Chosen from Abstracts WEDNESDAY, JANUARY 30 Adoptive Cellular Therapy Stanley R. Riddell, Fred Hutchinson Cancer Research Center, USA T Cell Subsets in Adoptive Therapy Nicholas P. Restifo, NCI, National Institutes of Health, USA Self-Renewal and Persistence of T Cell Subsets Catherine M. Bollard, Baylor College of Medicine, USA Adoptive T Cell Therapy Moving Beyond Phase I Studies Robert S. Negrin, Stanford University, USA Allogenic Bone Marrow Transplantation Short Talk(s) Chosen from Abstracts Metabolism and Cancer Laurence Zitvogel, Institut Gustave Roussy, France ATP and Tumor Cell Immunogenicity Vincenzo Bronte, University of Verona, Italy Myeloid Suppressive Mechanisms George C. Prendergast, Lankenau Institute for Medical Research, USA IDO/IDO2 Genetics and Therapeutic Correction of the IDO Pathway Short Talk Chosen from Abstracts THURSDAY, JANUARY 31 Immunomodulatory Antibody Therapies (Joint) Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA PD-1 Blockade in Cancer Therapy Nils Lonberg, Bristol-Myers Squibb, USA Development Hurdles for Immuno-Oncology Antibody Drugs Patrick A. Baeuerle, Micromet GmbH, Germany Cancer Therapy by Bispeciic, T Cell-Engaging Antibodies Speaker to be Announced Short Talk(s) Chosen from Abstracts Anti-Cancer Antibodies George J. Weiner, University of Iowa, USA Therapeutic Mechanisms of Monoclonal Antibodies Mark J. Smyth, Peter MacCallum Cancer Centre, Australia Monoclonal Antibody-Based Combinatorial Therapies Glenn Dranoff, Dana-Farber Cancer Institute, USA Therapy-Induced Antibody Responses Short Talk Chosen from Abstracts FRIDAY, FEBRUARY 1: DEPARTURE
Invited, not yet accepted
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 23 ADIPOSE TISSUE BIOLOGY JANUARY 27FEBRUARY 1, 2013 KEYSTONE RESORT, KEYSTONE, COLORADO, USA (venue information on page 45) Scientic Organizers: Susan K. Fried and Anthony W. Ferrante Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J5. JOINT WITH... SUNDAY, JANUARY 27: ARRIVAL & REGISTRATION MONDAY, JANUARY 28 Keynote Address (Joint) Craig B. Thompson, Memorial Sloan-Kettering Cancer Center, USA Metabolic Regulation in Cancer Biology Mechanisms of Metabolic Dysfunction and New Therapeutic Targets for Diabetes (Joint) Bruce M. Spiegelman, Harvard Medical School, USA PPAR Non-Agonists as Anti-Diabetic Therapy David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA FGF-19 in Metabolic Control Michael R. Jirousek, Catabasis Pharmaceuticals, Inc., USA Dual-Action Anti-Inlammatory Insulin Sensitizers Workshop 1: Measurement of Mitochondrial Function in vitro and in vivo Short Talks Chosen from Abstracts Losing Fat: Dynamics of Adipocyte Lipid Turnover Rudolf Zechner, University of Graz, Austria Molecular Regulation of Lipolysis Paul F. Pilch, Boston University School of Medicine, USA Caveolins and Lipolysis Richard N. Bergman, Cedars-Sinai Medical Center, USA Physiology: Oscillations in Adipocyte Lipolysis Short Talk Chosen from Abstracts TUESDAY, JANUARY 29 Remodeling a Healthy Adipose Tissue Silvia Corvera, University of Massachusetts Medical School, USA Feeding Fat and Vascular Remodeling Rajat Singh, Albert Einstein College of Medicine, USA When Fat Is Self-Absorbed Autophagy and Lipid Metabolism Chad A. Cowan, Harvard University, USA Adipocyte Ontogeny and Turnover Speaker to be Announced Short Talk(s) Chosen from Abstracts Epigenetics and Perinatal Imprinting in Diabetes and Obesity (Joint) C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA Diabetes and Obesity Nature vs. Nurture Anne Ferguson-Smith, University of Cambridge, UK Mechanisms of Genetic Imprinting Paolo Sassone-Corsi, University of California, Irvine, USA Epigenetic Control of Circadian Rhythms and Metabolism WEDNESDAY, JANUARY 30 Signaling Defects and Inlammation in Insulin Resistance (Joint) Diane J. Mathis, Harvard Medical School, USA T-Cell Function in Adipose Tissue Depots Anthony W. Ferrante, Columbia University, USA Macrophages in Insulin Resistance Ruslan M. Medzhitov, Yale University School of Medicine, USA Inlammation and Metabolism Ajay Chawla, University of California, San Francisco, USA Innate Control of Metabolism Workshop 2: Assessing Immune Cell Populations in Adipose Tissue: What Are the FACS? Short Talks Chosen from Abstracts Variation in the Biology of Adipose Depots Susan K. Fried, Boston Medical Center, USA Genes Regulating Fat Distribution in Men and Women James L. Kirkland, Mayo Clinic, USA Cellular Senescence and Adipocyte Tissue Speaker to be Announced Short Talk Chosen from Abstracts THURSDAY, JANUARY 31 Brown Adipose Tissue: Where There Is Smoke... Stephen R. Farmer, Boston University School of Medicine, USA Brite Fat-Molecular Mechanisms Sheila Collins, Sanford-Burnham Medical Research Institute, USA Converging Hormonal Signals that Spark the Brown-in-White Adipocyte Transformation Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA Developmental Control of Brown Adipose Tissue Short Talks Chosen from Abstracts Beyond Diabetes Complications of Obesity Kathryn J. Moore, New York University Medical Center, USA Atherosclerosis and Lipid Metabolism Mikhail G. Kolonin, University of Texas, USA Regulation of Tumor Progression by Adipose Tissue Speaker to be Announced Short Talk Chosen from Abstracts FRIDAY, FEBRUARY 1: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 24 DIABETES NEW INSIGHTS INTO MECHANISM OF DISEASE AND ITS TREATMENT Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J6. DEADLINES FOR BOTH CONFERENCES: ABSTRACT & SCHOLARSHIP SEP 27, 2012 LATE-BREAKING ABSTRACT OCT 29, 2012 DISCOUNTED REGISTRATION NOV 28, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13J5 or /13J6 Scientic Organizers: C. Ronald Kahn, Jens C. Brning and Gerald I. Shulman Sponsored by MedImmune Registering for one conference in a set of joint conferences enables participation in sessions of the other, pending space availability. SUNDAY, JANUARY 27: ARRIVAL & REGISTRATION MONDAY, JANUARY 28 Keynote Address (Joint) Craig B. Thompson, Memorial Sloan-Kettering Cancer Center, USA Metabolic Regulation in Cancer Biology Mechanisms of Metabolic Dysfunction and New Therapeutic Targets for Diabetes (Joint) Bruce M. Spiegelman, Harvard Medical School, USA PPAR Non-Agonists as Anti-Diabetic Therapy David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA FGF-19 in Metabolic Control Michael R. Jirousek, Catabasis Pharmaceuticals, Inc., USA Dual-Action Anti-Inlammatory Insulin Sensitizers miRNAs and Metabolic Disease Markus Stoffel, Institute of Molecular Systems Biology, Switzerland miRNAs in Control of -Cell Function Jens C. Brning, Institute for Genetics, University of Cologne, Germany miRNAs in Control of Liver Metabolism Anna Krook, Karolinska Institutet, Sweden Role of miRNA Let7 in Diabetes-Related Inlammation TUESDAY, JANUARY 29 Aging, Mitochondria and Control of Metabolism Andrew G. Dillin, The Salk Institute for Biological Studies, USA Humoral Control of Mitochondrial Form and Function Kitt F. Petersen, Yale University School of Medicine, USA Altered Mitochondrial Function in Muscle in Aging and Disease Eric M. Verdin, University of California, San Francisco, USA Reversible Acetylation in Regulation of Mitochondrial Function and Aging Domenico Accili, Columbia University, USA Talk Title to be Determined Epigenetics and Perinatal Imprinting in Diabetes and Obesity (Joint) C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA Diabetes and Obesity Nature vs. Nurture Anne Ferguson-Smith, University of Cambridge, UK Mechanisms of Genetic Imprinting Paolo Sassone-Corsi, University of California, Irvine, USA Epigenetic Control of Circadian Rhythms and Metabolism WEDNESDAY, JANUARY 30 Signaling Defects and Inlammation in Insulin Resistance (Joint) Diane J. Mathis, Harvard Medical School, USA T-Cell Function in Adipose Tissue Depots Anthony W. Ferrante, Columbia University, USA Macrophages in Insulin Resistance Ruslan M. Medzhitov, Yale University School of Medicine, USA Inlammation and Metabolism Ajay Chawla, University of California, San Francisco, USA Innate Control of Metabolism Gastric Bypass Surgery and the Gut in Control of Metabolism David E. Cummings, University of Washington, USA Metabolic Surgery: Endocrine Mechanisms of Diabetes Remission after Bariatric Operations Jin-Long Chen, NGM Biopharmaceuticals, Inc., USA New Gut Mediators of Bypass Surgery Lee M. Kaplan, Massachusetts General Hospital, USA Physiological Responses to Bariatric Surgery THURSDAY, JANUARY 31 Metabolic Mediators of Insulin Resistance Philipp E. Scherer, University of Texas Southwestern Medical Center, USA Ceramides as Mediators of Insulin Resistance Gerald I. Shulman, HHMI/Yale University School of Medicine, USA Novel PKCs as Mediators of Insulin Resistance Gkhan S. Hotamisligil, Harvard University, USA ER Stress as a Mediator of Insulin Resistance Reuben J. Shaw, The Salk Institute, USA AMPK Signaling Modulates Insulin Resistance CNS Control of Metabolism Joel K. Elmquist, University of Texas Southwestern Medical Center, USA CNS Control of Energy Balance and Peripheral Metabolism Christoph Buettner, Mount Sinai School of Medicine, USA Brain Control of Adipose Tissue Metabolism Richard M. Caprioli, Vanderbilt University Medical Center, USA Molecular Imaging of Tissue by Mass Spectrometry: Looking Beyond the Microscope FRIDAY, FEBRUARY 1: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 25 MITOCHONDRIA, METABOLISM AND MYOCARDIAL FUNCTION BASIC ADVANCES TO TRANSLATIONAL STUDIES FEBRUARY 38, 2013 KEYSTONE RESORT, KEYSTONE, COLORADO, USA (venue information on page 45) DEADLINES: ABSTRACT & SCHOLARSHIP OCT 3, 2012 LATE-BREAKING ABSTRACT OCT 31, 2012 DISCOUNTED REGISTRATION DEC 3, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13B1 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B1. Scientic Organizers: Michael N. Sack and Roberta Gottlieb SUNDAY, FEBRUARY 3: ARRIVAL & REGISTRATION MONDAY, FEBRUARY 4 Keynote Address Ana Maria Cuervo, Albert Einstein College of Medicine, USA Autophagy in Cellular Energy Balance The Biology of Mitochondrial Homeostatic Regulatory Programs and Cardiac Disease Roberta Gottlieb, San Diego State University, USA The Role of Mitophagy in Mitochondrial Biogenesis Orian S. Shirihai, Boston University, USA The Interplay between Mitochondrial Dynamics and Autophagy Kinya Otsu, Osaka University, Japan Mitochondrial DNA in the Development of Cardiac Inlammation and Dysfunction Joseph A. Hill, University of Texas Southwestern Medical Center, USA Autophagy and the Failing Heart Short Talk Chosen from Abstracts Regulation of Redox Stress in Cardiovascular Disease Junichi Sadoshima, University of Medicine and Dentistry of New Jersey, USA The Role of NADPH Oxidases in Mediating Oxidative Stress in Mitochondria Gerald S. Shadel, Yale University, USA Mitochondrial ROS Signaling in Disease and Aging Jeffery D. Molkentin
, Cincinnati Children's Hospital
Medical Center, USA Novel Pathways to Augment ER Stress Protection in the Heart Short Talk Chosen from Abstracts TUESDAY, FEBRUARY 5 Metabolic Modulation in the Pathogenesis and Treatment of Cardiac Hypertrophy and Heart Failure Jan F. Glatz, Maastricht University, Netherlands Novel Signaling Pathways Regulating Substrate Switching in the Heart Martin E. Young, University of Alabama at Birmingham, USA The Circadian Clock, Metabolic Regulation and Cardiac Pathology Gary D. Lopaschuk, University of Alberta, Canada Modulation of Malonyl-CoA and Cardiac Metabolic Consequences William C. Stanley, University of Maryland, USA Mitochondrial Pathology in Heart Failure: Novel Therapeutic Approaches Short Talk(s) Chosen from Abstracts Emerging Regulatory Programs in the Control of Mitochondria and Metabolism Elizabeth Murphy, NHLBI, National Institutes of Health, USA S-nitrosylation in the Control of Mitochondrial Stress Response Michael N. Sack, NHLBI, National Institutes of Health, USA Mitochondrial Protein Acetylation and the Control of Mitochondrial Metabolism Eric N. Olson, University of Texas Southwestern Medical Center, USA The Role of MED13 in Regulating Cardiac Mitochondrial Metabolism and Systemic Insulin Resistance Short Talk Chosen from Abstracts WEDNESDAY, FEBRUARY 6 Nutrient Stressors and the Modulation of Cardiovascular Function Gkhan S. Hotamisligil, Harvard University, USA ER Stress, Obesity and Atherosclerosis E. Dale Abel, University of Utah School of Medicine, USA Obesity-Mediated Disruption of Cardiac Mitochondrial Function Jason Dyck, University of Alberta, Canada Caloric Restriction and Cardiovascular Function Daniel P. Kelly, Sanford-Burnham Medical Research Institute, USA Myocyte Lipotoxicity Screening to Delineate Mechanisms and Drug Targets Short Talk(s) Chosen from Abstracts Emerging Technologies to Characterize Mitochondrial and Metabolic Functioning Robert S. Balaban, NHLBI, National Institutes of Health, USA Systems Biology of Mitochondria Peipei Ping, University of California, Los Angeles, USA Metabolic Lessons from Unbiased Large-Scale Proteomic Studies Christopher B. Newgard, Duke University Medical Center, USA Metabolomics Applied to Cardiovascular Diseases Short Talk Chosen from Abstracts THURSDAY, FEBRUARY 7 Novel Programs Controlling Mitochondria and Metabolism Vamsi K. Mootha, Massachusetts General Hospital, USA Identiication of the Mitochondrial Calcium Uniporter Christine Des Rosiers, Montreal Heart Institute (MHI), Canada Metabolomics: What Have We Learned from Heart Failure Patients? Johan Auwerx, cole Polytechnique Fdrale de Lausanne (EPFL), Switzerland Transcriptional Corepressors in the Control of Mitochondrial Homeostasis Thomas Langer, University of Cologne, Germany Quality Control of Mitochondrial Proteostasis Short Talk(s) Chosen from Abstracts Clinical Studies to Advance Biological Insight and Therapeutic Targets Lawrence Young, Yale University, USA AMPK and the Modulation of Mitochondrial Function Patrick Schrauwen, Maastricht University, Netherlands Lipotoxicity, Mitochondria and Cardiac Function: Insight from Human Clinical Intervention Studies Anthony J. Muslin, Novartis Institutes for BioMedical Research, Inc., USA Modulation of Signaling Pathways to Treat Cardiovascular Disease Short Talk Chosen from Abstracts FRIDAY, FEBRUARY 8: DEPARTURE
Invited, not yet accepted.
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 26 SNOWBIRD RESORT SNOWBIRD, UTAH, USA Local elevation: 8150 (2484 m) Local airport/distance to venue: Salt Lake City International (SLC)/ 32 mi (52 km) SHERATON STEAMBOAT RESORT STEAMBOAT SPRINGS, COLORADO, USA SAGEBRUSH INN & CONFERENCE CENTER TAOS, NEW MEXICO, USA GRANLIBAKKEN RESORT TAHOE CITY, CALIFORNIA, USA Local elevation: 6900 (2103 m) Local airports/distances to venue: Yampa Valley Regional (HDN)/27 mi (43 km); Denver International (DEN)/178 mi (286 km) Local elevation: 6950 (2118 m) Local airports/distances to venue: Albuquerque International Sunport ABQ mi km Santa Fe Nunicipal SAF mi km Local elevation: 6900 (2103 m) Local airport/distance to venue: Reno/Tahoe International (RNO)/ 52 mi (84 km) JW MARRIOTT NEW ORLEANS NEW ORLEANS, LOUISIANA, USA Local elevation: 1 (0.3 m) Local airport/distance to venue: Louis Armstrong New Orleans International (MSY)/13 mi (21 km) BEAVER RUN RESORT BRECKENRIDGE, COLORADO, USA Local elevation: 9600 (2926 m) Local airport/distance to venue: Denver International (DEN)/ 100 mi (161 km) 27 NEUROGENESIS FEBRUARY 38, 2013 SANTA FE COMMUNITY CONVENTION CENTER, SANTA FE, NEW MEXICO, USA (venue information on page 21) Scientic Organizers: Hongjun Song, Yukiko Gotoh, Yi Eve Sun and Gerd Kempermann Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J7. JOINT WITH... SUNDAY, FEBRUARY 3: ARRIVAL & REGISTRATION MONDAY, FEBRUARY 4 Keynote Address Fred H. Gage, The Salk Institute for Biological Studies, USA Neurogenesis and Neurological Disorders: Lessons from Studies of Adult Neurogenesis and Patient-Derived iPSCs Neurogenesis and Gliogenesis Gordon J. Fishell, New York University Medical Center, USA The Role of Genetics and Activity in the Generation of Cortical Neuron Subtypes Jonas Frisn, Karolinska Institutet, Sweden Gliogenesis in Postnatal CNS Dwight E. Bergles, Johns Hopkins University School of Medicine, USA NG2+ OPCs and Role in ALS Patrik Ernfors, Karolinska Institutet, Sweden Cell Type Speciiciation in the Neural Crest Short Talk Chosen from Abstracts Model Systems Tzumin Lee, HHMI/Janelia Farm Research Campus, USA Lineage Analysis with Twin-Spot MARCM in Drosophila Arnold Kriegstein, University of California, San Francisco, USA oSVZ Neurogenesis in Developing Mouse and Human Cortex Su-Chun Zhang, University of Wisconsin-Madison, USA Generation of Diverse Neural Subtypes from Pluripotent Human Stem Cells Short Talk Chosen from Abstracts TUESDAY, FEBRUARY 5 Neurogenesis and Development: Molecular Mechanisms Yukiko Gotoh, University of Tokyo, Japan Regulation of Neural Stem/Progenitor Cell Fate during Mouse Development Soo-Kyung Lee, Oregon Health & Science University, USA Gene Regulatory Networks in Spinal Cord Neurogenesis Francois Guillemot, National Institute for Medical Research, UK Transcriptional Control of Stem Cell Fates in the Embryonic and Adult Brain Jenny Hsieh, University of Texas Southwestern Medical Center, USA Signaling Mechanism in Adult Neurogenesis Short Talk(s) Chosen from Abstracts Stem Cell Niches in the Developing and Adult Brain Christopher A. Walsh, Childrens Hospital Boston, USA Niche for Embryonic Cortical Neurogenesis Andrea Brand, University of Cambridge, UK Nutrient Control of Neural Stem Cells Chay T. Kuo, Duke University Medical Center, USA Sustaining New Neuron Production in the SVZ Niche Short Talk Chosen from Abstracts WEDNESDAY, FEBRUARY 6 Epigenetics and Genomics (Joint) Yi Eve Sun, University of California, Los Angeles, USA DNA Methylome during Developmental Neurogenesis Andr Fischer, European Neuroscience Institute Gttingen, Germany Histone Modiications in Degenerative Neurological Disorders Daniel H. Geschwind, University of California, Los Angeles, USA Functional Genomic Analyses of Pathways Dysregulated in Frontal Temporal Dementia Hongjun Song, Johns Hopkins University School of Medicine, USA Activity-Induced Modiication of Neuronal DNA Methylome Short Talk(s) Chosen from Abstracts Adult Neurogenesis: Regulation and Functions Gerd Kempermann, Technische Universitt Dresden, Germany Systems Biology of Adult Neurogenesis and its Function Pierre-Marie Lledo, Pasteur Institute, France Adult Neurogenesis and Olfaction Shaoyu Ge, SUNY Stony Brook, USA Optogenetic Probing of Adult Neurogenesis Function Short Talk Chosen from Abstracts THURSDAY, FEBRUARY 7 Adult Neurogenesis under Pathological Conditions Xinyu Zhao, University of Wisconsin, USA Adult Neurogenesis and Fragile X Syndrome Heather A. Cameron, NIMH, National Institutes of Health, USA Adult Neurogenesis, Stress and Depression Randall Reed, Johns Hopkins University, USA Olfactory Epithelium Neurogenesis after Injury Jack M. Parent, University of Michigan, USA Adult Neurogenesis after Injury Short Talk(s) Chosen from Abstracts iPSC Modeling of Developmental and Degenerative Neurological Diseases (Joint) Guo-li Ming, Johns Hopkins University, USA iPSCs Derived from Schizophrenia Patients with a DISC1 Mutation Anirvan Ghosh, Hoffmann-La Roche, Switzerland Small Molecule Screen of hESCs and Patient-Derived iPSCs Kevin C. Eggan, Harvard University, USA Modeling ALS Using iPSCs Short Talk Chosen from Abstracts FRIDAY, FEBRUARY 8: DEPARTURE
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 28 NEW FRONTIERS IN NEURODEGENERATIVE DISEASE RESEARCH Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13J8. DEADLINES FOR BOTH CONFERENCES: ABSTRACT & SCHOLARSHIP OCT 4, 2012 LATE-BREAKING ABSTRACT NOV 1, 2012 DISCOUNTED REGISTRATION DEC 4, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13J7 or /13J8 Scientic Organizers: Li-Huei Tsai, Steven M. Paul and Michael Hutton Sponsored by Vertex Pharmaceuticals Incorporated Registering for one conference in a set of joint conferences enables participation in sessions of the other, pending space availability. SUNDAY, FEBRUARY 3: ARRIVAL & REGISTRATION MONDAY, FEBRUARY 4 Keynote Address Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA Modeling Pathology in Simpler Cells Protein Aggregation and Propagation of Misfolded Proteins in the Brain Virginia M. Y. Lee, University of Pennsylvania School of Medicine, USA Protein Aggregation in Alzheimers Disease and Frontal Temporal Dementia John Collinge, Institute of Neurology, University College London, UK Prion Disease Mathias Jucker, Universitt Tbingen, Germany Propagation of Misfolded Proteins in the Brain Jeffery W. Kelly, The Scripps Research Institute, USA Strategies to Ameliorate Neurodegenerative Diseases by Adapting the Proteostasis Network Short Talk Chosen from Abstracts Mechanisms of Early Disease Intervention and Biomarkers John Q. Trojanowski, University of Pennsylvania, USA Alzheimers Biomarkers and Tau-Focused Therapies Ronald B. DeMattos, Lilly Research Laboratories, USA The Use of Biomarkers in the Development of AD Therapies Rosa Rademakers, Mayo Clinic, USA Frontal Temporal Dementia and Amyotrophic Lateral Sclerosis Short Talk Chosen from Abstracts TUESDAY, FEBRUARY 5 Molecular Mechanisms of Neuronal Vulnerability Myriam Heiman, Massachusetts Institute of Technology, USA TRAPping Parkinsons and Huntingtons Diseases Michael R. Hayden, University of British Columbia, Canada Huntingtons Disease Valina L. Dawson, Johns Hopkins University School of Medicine, USA Mechanisms of Cell Death in Neurodegeneration Steven M. Paul, Weill Cornell Medical College, USA ApoE, Amyloid Deposition and A Clearance Short Talk(s) Chosen from Abstracts Novel Approaches for the Therapeutic Intervention of Neurodegenerative Disease Anders Bjorklund, Lund University, Sweden Blockade of -Synuclein-Induced Neurodegeneration by Gene Therapy Approaches Ryan J. Watts, Genentech, Inc., USA Targeting Neurodegeneration by Boosting Antibody Uptake in Brain Michael Hutton, Lilly UK, UK Clearance of Tau Short Talk Chosen from Abstracts WEDNESDAY, FEBRUARY 6 Epigenetics and Genomics (Joint) Yi Eve Sun, University of California, Los Angeles, USA DNA Methylome during Developmental Neurogenesis Andr Fischer, European Neuroscience Institute Gttingen, Germany Histone Modiications in Degenerative Neurological Disorders Daniel H. Geschwind, University of California, Los Angeles, USA Functional Genomic Analyses of Pathways Dysregulated in Frontal Temporal Dementia Hongjun Song, Johns Hopkins University School of Medicine, USA Activity-Induced Modiication of Neuronal DNA Methylome Short Talk(s) Chosen from Abstracts Aging and Genome Integrity Bruce A. Yankner, Harvard Medical School, USA DNA Damage in Aging and Neurodegenerative Disorders Peter J. McKinnon, St. Jude Childrens Research Hospital, USA Defective DNA Damage Signaling and Neurodegeneration Li-Huei Tsai, Massachusetts Institute of Technology, USA Genome Integrity, Chromatin Remodeling and Neurodegenerative Disorders Short Talk Chosen from Abstracts THURSDAY, FEBRUARY 7 Neurobiology of Disease David M. Holtzman, Washington University, USA Regulation of -Amyloid by Neuronal Activity Ted M. Dawson, Johns Hopkins School of Medicine, USA Molecular Basis of Parkinsons Disease Li Gan, University of California, San Francisco, USA Adult Stem Cells in Aging and Neurodegenerative Disorders Marc Tessier-Lavigne, Rockefeller University, USA Axon Degeneration in Development and Disease Short Talk(s) Chosen from Abstracts iPSC Modeling of Developmental and Degenerative Neurological Diseases (Joint) Guo-li Ming, Johns Hopkins University, USA iPSCs Derived from Schizophrenia Patients with a DISC1 Mutation Anirvan Ghosh, Hoffmann-La Roche, Switzerland Small Molecule Screen of hESCs and Patient-Derived iPSCs Kevin C. Eggan, Harvard University, USA Modeling ALS Using iPSCs Short Talk Chosen from Abstracts FRIDAY, FEBRUARY 8: DEPARTURE
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 29 LUNG DEVELOPMENT, CANCER AND DISEASE FEBRUARY 510, 2013 SAGEBRUSH INN AND CONFERENCE CENTER, TAOS, NEW MEXICO, USA (venue information on page 27) DEADLINES: ABSTRACT & SCHOLARSHIP OCT 8, 2012 LATE-BREAKING ABSTRACT NOV 5, 2012 DISCOUNTED REGISTRATION DEC 5, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13B2 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B2. TUESDAY, FEBRUARY 5: ARRIVAL & REGISTRATION WEDNESDAY, FEBRUARY 6 Keynote Address Anton J.M. Berns, Netherlands Cancer Institute, Netherlands Cell of Origin of Lung Cancer Lung Development Mark A. Krasnow, Stanford University School of Medicine, USA Genetic Dissection of Lung Development and Disease James M. Wells, Cincinnati Childrens Hospital Research Foundation, USA Speciication and Patterning of Foregut Endoderm Xin Sun, University of Wisconsin, USA Branching Morphogenesis of the Lung Emma Rawlins, University of Cambridge, UK Multipotent Epithelial Progenitor Cells in the Developing Lung Short Talk Chosen from Abstracts Workshop 1: Lung Cell Replacement Short Talks Chosen from Abstracts Speciication, Differentiation and Patterning of Airway Epithelial Cell Lineages Jeffrey A. Whitsett, Cincinnati Childrens Hospital Medical Center, USA Transcription Factors in Lung Development and Disease Eszter Katalin Vladar, Stanford University School of Medicine, USA Mechanisms Regulating Epithelial Planar Cell Polarity in the Developing Lung John F. Engelhardt, University of Iowa, USA Development and Maintenance of the Submucosal Gland Stem/ Progenitor Cell Niche Short Talk Chosen from Abstracts THURSDAY, FEBRUARY 7 Lung Cancer and COPD David M. Ornitz, Washington University School of Medicine, USA FGF Signaling Pathways in Lung Development and Cancer Christin S. Kuo, Stanford University, USA Neuroendocrine Cell Development and Small Cell Lung Cancer Speaker to be Announced Avrum Spira, Boston University, USA The Airway Field of Injury in Lung Cancer and COPD Short Talk(s) Chosen from Abstracts Lung Mesodermal Lineages and Vascularization Patrick E. Bogard, Stanford University School of Medicine, USA Development and the Lung Vasculature Maya Kumar, Stanford University, USA Embryonic Origin of Mesodermal Lineages in the Lung Bruce C. Trapnell, University of Cincinnati College of Medicine, USA GM-CSF, Lung Macrophages and PAP Short Talk Chosen from Abstracts FRIDAY, FEBRUARY 8 Alveolar Development, Vascular Remodeling and Alveolar Disease Tushar Desai, Stanford University, USA Lung Adenocarcinoma and Alveolar Remodeling Daniel B. Rikin, New York University, USA TGF- Signaling, Extracellular Matrix and Lung Development Mark Looney, University of California, San Francisco, USA Real-Time Imaging of Cell Traficking in Lung Alveoli Vladimir V. Kalinichenko, Cincinnati Childrens Hospital Medical Center, USA Transcriptional Regulation of Endothelial Cells during Lung Development and Alveolar Disease Short Talk(s) Chosen from Abstracts Workshop 2: Models of Injury and Repair in the Lung: Basic Science and Novel Therapeutics Short Talks Chosen from Abstracts Lung Progenitor Cells and Lung Disease Brigid L.M. Hogan, Duke University Medical Center, USA Airway Stem Cells Frank McKeon, A
STAR/Harvard Medical School, USA
Lung Regeneration Henry Danahay, Novartis Institutes for BioMedical Research, UK Regulation of Cell Fate Decisions in the Airway Short Talk Chosen from Abstracts SATURDAY, FEBRUARY 9 Lung and Tissue Fibrosis Christine Kim Garcia, University of Texas Southwestern Medical Center, USA Cellular Stress and Lung Fibrosis Andreas Gnther, University of Giessen Lung Center, Germany Signaling Mechanisms in Lung Fibrosis Jeremy S. Dufield, University of Washington, USA Pericytes and Tissue Fibrosis Steven R. Ledbetter, Genzyme Corporation, USA TGF- Signaling in Chronic Disease Short Talk(s) Chosen from Abstracts New Insights from Genetic Analysis of Rare Lung Diseases Enid R. Neptune, Johns Hopkins University, USA Cellular Mechanisms Associated with Cutis laxa, Fibulins, TGF- and Lung Disease Speaker to be Announced Esteban Carlos DellAngelica, University of California, Los Angeles, USA Molecular Basis of Hermansky-Pudlak Syndrome Short Talk Chosen from Abstracts SUNDAY, FEBRUARY 10: DEPARTURE
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 30 Scientic Organizers: Brigid L.M. Hogan, Jeffrey A. Whitsett and Christine Kim Garcia Sponsored by Innity Pharmaceuticals THE GUT MICROBIOME: THE EFFECTOR/ REGULATORY IMMUNE NETWORK FEBRUARY 1015, 2013 SAGEBRUSH INN AND CONFERENCE CENTER, TAOS, NEW MEXICO, USA (venue information on page 27) DEADLINES: ABSTRACT & SCHOLARSHIP OCT 9, 2012 LATE-BREAKING ABSTRACT NOV 8, 2012 DISCOUNTED REGISTRATION DEC 5, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13B3 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B3. SUNDAY, FEBRUARY 10: ARRIVAL & REGISTRATION MONDAY, FEBRUARY 11 Keynote Address Dan R. Littman, New York University School of Medicine, USA The Gut Commensal Microbiotas Effects on Systemic Autoimmunity The Gut Microbiome Curtis Huttenhower, Harvard School of Public Health, USA Large-Scale Genomic Data Mining of the Human Microbiome David A. Relman, Stanford University, USA Assembly, Stability and Resilience of the Human Microbiome S. Dusko Ehrlich, Institut National de la Recherche Agronomique (INRA), France The Human Metagenome Short Talk(s) Chosen from Abstracts Gut Microbiome and Immune Development Chyi-Song Hsieh, Washington University, USA Education of the Immune System by Commensal Microbiota Ruth E. Ley, Cornell University, USA Adaptive Immune Regulation of Bacterial Motility and Community Structure Susan V. Lynch, University of California, San Francisco, USA Gastrointestinal Microbiome and Pediatric Asthma Development Short Talk Chosen from Abstracts TUESDAY, FEBRUARY 12 Gut Microbiome-APC Interactions B. Brett Finlay, University of British Columbia, Canada The Interface between the Immune System and Microbiota in Infectious and Allergic Diseases Dennis L. Kasper, Harvard Medical School, USA Modulation of Immune Responses by Commensal Microbes Brian L. Kelsall, NIAID, National Institutes of Health, USA A Focus on Dendritic Cells and Macrophages as Key Regulators of Mucosal Immunity Grard Eberl, Institut Pasteur, France Development and Function of Intestinal Innate Lymphoid Cells Short Talk(s) Chosen from Abstracts Experimental Colitis/IBD: Regulator Networks Sarkis K. Mazmanian, California Institute of Technology, USA Learning to Tolerate Our Microbial Self Richard S. Blumberg, Brigham and Womens Hospital, USA Microbial Exposure during Early Life Has Persistent Effects on Natural Killer T Cell Function David Artis, University of Pennsylvania School of Medicine, USA CD4(+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut Short Talk Chosen from Abstracts WEDNESDAY, FEBRUARY 13 Gut Bacteria Modulation of Effector Networks Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA Regulation of Innate and Adaptive Immunity by the Commensal Microbiota Nadine Cerf-Bensussan, Universit Paris Descartes, France The Variable Trade-Off between Commensal Bacteria and the Gut Immune System Gabriel Nuez, University of Michigan, USA In Development of Natural Th17 Cell in the Intestine through IL-1b Fiona M. Powrie, University of Oxford NDM, UK Interleukin-23 Drives Intestinal Inlammation through Direct Activity on T Cells Short Talk(s) Chosen from Abstracts Gut Modulation of Effector/Regulatory Networks in CNS Disease Gurumoorthy Krishnamoorthy, Max Planck Institute of Neurobiology, Germany Commensal Microbiota as a Trigger of Spontaneous Autoimmune Demyelination Yun Kyung Lee, California Institute of Technology, USA Proinlammatory T-Cell Responses to Gut Microbiota Promote Experimental Autoimmune Encephalomyelitis Lloyd H. Kasper, Dartmouth Medical School, USA Role of Commensal Bacteria in the Regulation of Central Nervous System Disease Demyelination Short Talk Chosen from Abstracts THURSDAY, FEBRUARY 14 Modulation of Gut Microbiota and Autoimmunity Peter J. Turnbaugh, Harvard University, USA The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice Duccio Cavalieri, Universit di Firenze, Italy Microbiota in Children of Divergent Cultures Fergus Shanahan, National University of Ireland, Ireland Diet, Microbes and Metabolic Health Javier Ochoa-Repraz, EMD Serono, Inc., USA The Gut as a Source of Small Molecule Therapeutics Short Talk(s) Chosen from Abstracts Gut Bacteria Modulation of Autoimmunity Mogens Jakobsen, University of Copenhagen, Denmark Gut Microbiota and Diabetes Alexander Chervonsky, University of Chicago, USA Innate Immune Signaling and the Gut Microbiota in Type 1 Diabetes Diane J. Mathis, Harvard Medical School, USA Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cell FRIDAY, FEBRUARY 15: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 31 Scientic Organizers: Lloyd H. Kasper, Javier Ochoa-Repraz and Sarkis K. Mazmanian Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc. B CELL DEVELOPMENT AND FUNCTION FEBRUARY 1015, 2013 KEYSTONE RESORT, KEYSTONE, COLORADO, USA (venue information on page 45) Scientic Organizers: Max D. Cooper, Andrea Cerutti and Carola G. Vinuesa Sponsored by Onyx Pharmaceuticals, Inc. Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X1. JOINT WITH... SUNDAY, FEBRUARY 10: ARRIVAL & REGISTRATION Keynote Session (Joint) Myron S. Cohen, University of North Carolina at Chapel Hill, USA HIV Prevention: Lessons Learned and the Changing Landscape for HIV Vaccines Michel C. Nussenzweig, Rockefeller University, USA The Human Antibody Response to HIV MONDAY, FEBRUARY 11 B Cell Genesis Ana Cumano, Institut Pasteur, France Mechanisms for B Cell Commitment of Hematopoietic Progenitors Thomas Graf, Center for Genomic Regulation, Spain Factors Regulating B Cell to Myeloid Cell Conversion Rudolf Grosschedl, Max Planck Institute of Immunobiology and Epigenetics, Germany Mechanisms Underlying Transcriptional Control of B Cell Differentiation Frederick W. Alt, HHMI/Childrens Hospital Boston and Immune Disease Institute, USA Regulation and Dysregulation of V(DJ Gene Recombination Early Events in B Cell Activation Facundo D. Batista, Cancer Research UK London Research Institute, UK Dynamic Imaging of Lymphocyte Activation From Single Molecule to Living Tissue Michael Reth, Max Planck Institute of Immunobiology and Epigenetics, Germany Role of Protein Islands for the Activation of B Cells Susan K. Pierce, NIAID, National Institutes of Health, USA Molecular Assembly of BCR Oligomers Short Talk Chosen from Abstracts TUESDAY, FEBRUARY 12 B Cell Evolution and Repertoire Selection Max D. Cooper, Emory University, USA Evolution of Adaptive Immunity in Vertebrates Garnett H. Kelsoe, Duke University Medical Center, USA Genetic Control of the First Tolerance Checkpoint in B Cells Hedda Wardemann, Max Planck Institute for Infection Biology, Germany V(DJ Gene Repertoire in Adult B Cells Michael S. Neuberger, Medical Research Council, UK Mechanisms of Somatic Hypermutation and Class Switch Recombination via AID Short Talk(s) Chosen from Abstracts Mucosal Antibody Responses (Joint) Andrea Cerutti, Mount Sinai School of Medicine, USA Regulation and Function of Mucosal IgA and IgD in Humans Sidonia Fagarasan, RIKEN Research Center for Allergy and Immunology, Japan IgA Class Switching in Intestinal Follicles Andrew J. Macpherson, University of Bern, Switzerland IgA Against Commensal Intestinal Microbes Induction and Function Short Talk Chosen fro m Abstracts WEDNESDAY, FEBRUARY 13 Germinal Center, Plasma Cell and Memory B Cell Differentiation Carola G. Vinuesa, Australian National University, Australia Role of T Follicular Helper Cells in the Germinal Center Reaction Jason G. Cyster, University of California, San Francisco, USA In vivo Traficking of Follicular B Cells Jacques F. Banchereau, Hoffmann-La Roche Inc., USA Regulation of Human Plasma Cell Differentiation Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan In vivo Traficking of Follicular B Cells Short Talk(s) Chosen from Abstracts Protective Antibody Responses Against HIV (Joint) Barton F. Haynes, Duke University Medical Center, USA Mechanisms of Protection by Broadly Reactive Neutralizing Antibodies to HIV Envelope Peter D. Kwong, NIAID, National Institutes of Health, USA Structural Biology of Neutralizing Epitopes on HIV Envelope Dennis R. Burton, The Scripps Research Institute, USA Antibody Protection Against HIV Georgia D. Tomaras, Duke University Medical Center, USA Spectrum of Vaccine-Elicited Humoral Immune Responses THURSDAY, FEBRUARY 14 MicroRNAs and B Cell Neoplasias Louis M. Staudt, NCI, National Institutes of Health, USA Biology and Treatment of B Cell Lymphoma David Baltimore, California Institute of Technology, USA MicroRNAs, Inlammation and Cancer Riccardo Dalla-Favera, Columbia University, USA Molecular Pathogenesis of B Cell Lymphoma Klaus Rajewsky, Max Delbrck Center for Molecular Medicine, Germany MicroRNAs in Normal and Neoplastic B Cells Short Talk(s) Chosen from Abstracts Autoimmunity and Regulatory B Cells Betty Diamond, Feinstein Institute for Medical Research, USA Negative Regulation of Peripheral Autoreactive B Cells Robert Brink, Garvan Institute of Medical Research, Australia New Mechanisms for the Activation of Autoreactive B Cells Edgar G. Engleman, Stanford University, USA B Cells and Insulin Resistance Short Talk Chosen from Abstracts FRIDAY, FEBRUARY 15: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 32 HIV VACCINES Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X2. DEADLINES FOR BOTH CONFERENCES: GLOBAL HEALTH TRAVEL AWARD SEP 11, 2012 ABSTRACT & SCHOLARSHIP OCT 10, 2012 LATE-BREAKING ABSTRACT NOV 12, 2012 DISCOUNTED REGISTRATION DEC 10, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13X1 or /13X2 Scientic Organizers: Georgia D. Tomaras, Quentin J. Sattentau and Barbara L. Shacklett Supported by the Ofce of AIDS Research, NIH; Sponsored by Gilead Sciences, Inc. Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation Registering for one conference in a set of joint conferences enables participation in sessions of the other, pending space availability. SUNDAY, FEBRUARY 10: ARRIVAL & REGISTRATION Keynote Session (Joint) Myron S. Cohen, University of North Carolina at Chapel Hill, USA HIV Prevention: Lessons Learned and the Changing Landscape for HIV Vaccines Michel C. Nussenzweig, Rockefeller University, USA The Human Antibody Response to HIV MONDAY, FEBRUARY 11 Protective Responses in Animal Models David H. OConnor, University of Wisconsin-Madison, USA Genetics and SIV Protection Genoveffa Franchini, NCI, National Institutes of Health, USA Correlates of Protection in NHP Kevin O. Saunders, NIAID, National Institutes of Health, USA Short Talk: The Passive Immunization and Transfer of VRC01 in Rhesus Macaques Ruth M. Ruprecht, Dana-Farber Cancer Institute, USA Passive Immunization Against Mucosal R5 SHIV Transmission Sallie Permar, Duke University Medical Center, USA Immune Protection Against Postnatal HIV/SIV Transmission Short Talk Chosen from Abstracts Workshop 1: Vaccine-Elicited Immune Responses and Potential Correlates Short Talks Chosen from Abstracts Potentially Protective Responses in Human Clinical Trials Merlin L. Robb, Walter Reed Army Institute of Research, USA Key Findings from RV Studies Glenda Gray, University of the Witwatersrand, South Africa Key Findings from South African Trials Barney S. Graham, NIAID, National Institutes of Health, USA Active and Passive Immunity Against HIV Short Talk Chosen from Abstracts TUESDAY, FEBRUARY 12 Quality of Immune Response (Immune Geography and Memory) Ronald N. Germain, NIAID, National Institutes of Health, USA Imaging Immune Cell Dynamics and Function Jacob D. Estes, NCI, National Institutes of Health, USA Early Events following SIV Challenge Mario Roederer, NIAID, National Institutes of Health, USA Determination of Immune Response Quality Speaker Chosen from Abstracts Short Talk(s) Chosen from Abstracts Mucosal Antibody Responses (Joint) Andrea Cerutti, Mount Sinai School of Medicine, USA Regulation and Function of Mucosal IgA and IgD in Humans Sidonia Fagarasan, RIKEN Research Center for Allergy and Immunology, Japan IgA Class Switching in Intestinal Follicles Andrew J. Macpherson, University of Bern, Switzerland IgA Against Commensal Intestinal Microbes Induction and Function Short Talk Chosen from Abstracts WEDNESDAY, FEBRUARY 13 CD8 and CD4 T Cell Immunity Hendrik Streeck, Massachusetts General Hospital, Harvard Medical School, USA Impact of CD4 T Cell Help/TFH Cells Olivier Lambotte, INSERM U1012, France Cellular Control of HIV-1 Infection Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA Properties of Protective CD8 T Cell Responses Barbara L. Shacklett, University of California, Davis, USA T Cell Immunity: Systemic and Mucosal Short Talk(s) Chosen from Abstracts Workshop 2: Immune Memory Short Talks Chosen from Abstracts Protective Antibody Responses Against HIV (Joint) Barton F. Haynes, Duke University Medical Center, USA Mechanisms of Protection by Broadly Reactive Neutralizing Antibodies to HIV Envelope Peter D. Kwong, NIAID, National Institutes of Health, USA Structural Biology of Neutralizing Epitopes on HIV Envelope Dennis R. Burton, The Scripps Research Institute, USA Antibody Protection Against HIV Georgia D. Tomaras, Duke University Medical Center, USA Spectrum of Vaccine-Elicited Humoral Immune Responses THURSDAY, FEBRUARY 14 New Concepts in Innate Immunity and Stimulation Nina Bhardwaj, New York University School of Medicine, USA Innate Stimulation Steven Reed, Infectious Disease Research Institute, USA Novel Adjuvants and Immune Stimulation Karin Lor, Karolinska Institutet, Sweden Innate Stimulation for Generating Potent HIV Immune Responses Short Talks Chosen from Abstracts Antibody Genomics and Immunogen Design John R. Mascola, NIAID, National Institutes of Health, USA Genetics of Antibody Elicitation William Schief, The Scripps Research Institute, USA Structure-Based HIV Vaccine Design Susan W. Barnett, Novartis Vaccines and Diagnostics, Inc., USA Selection of Envs and Adjuvants for Vaccine Evaluation Quentin J. Sattentau, Sir William Dunn School of Pathology, UK Chemical Modiications of Env for Vaccine Design FRIDAY, FEBRUARY 15: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 33 AUTOPHAGY, INFLAMMATION AND IMMUNITY FEBRUARY 1722, 2013 FAIRMONT THE QUEEN ELIZABETH, MONTREAL, QUEBEC, CANADA (venue information on page 45) DEADLINES: ABSTRACT & SCHOLARSHIP OCT 16, 2012 LATE-BREAKING ABSTRACT NOV 15, 2012 DISCOUNTED REGISTRATION DEC 13, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13B4 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B4. SUNDAY, FEBRUARY 17: ARRIVAL & REGISTRATION MONDAY, FEBRUARY 18 Keynote Address Douglas R. Green, St. Jude Childrens Research Hospital, USA Autophagy and the Immunological Impact of Dying Cells Mechanisms of Autophagy Noboru Mizushima, Tokyo Medical and Dental University, Japan Mammalian Atg Proteins in Autophagosome Formation Sharon A. Tooze, London Research Institute, UK Initiation of the Autophagosomal Membrane Mark J. Daly
, Harvard Medical School, USA
Autophagy Genes in Human Disease Short Talk(s) Chosen from Abstracts Selective Autophagy and Infection Ivan Dikic, Goethe University Medical School, Germany Autophagy Receptors and Bacterial Autophagy Beth Levine, University of Texas Southwestern Medical Center, USA Novel Mediators of Selective Virophagy and Mitophagy Tamotsu Yoshimori, Osaka University, Japan Mechanisms of Membrane Dynamics in Selective and Non-Selective Autophagy Short Talk Chosen from Abstracts TUESDAY, FEBRUARY 19 Autophagy and Infection Pascale Cossart, Institut Pasteur, France Autophagy and Cytosolic Bacteria Robert L. Modlin, University of California, Los Angeles, USA Vitamin D, Autophagy and Tuberculosis Vojo Deretic, University of New Mexico, USA Autophagy, Host Defense and Inlammation in Tuberculosis Fulvio Reggiori, University Medical Centre Utrecht, Netherlands The Autophagosomal Membrane and LC3-Positive Membranes Involved in Viral Infection Short Talk(s) Chosen from Abstracts Workshop Short Talks Chosen from Abstracts Autophagy and Immunity Speaker to be Announced Late-Breaking Research Herbert (Skip) W. Virgin IV, Washington University School of Medicine, USA Autophagy Proteins and Macrophage-Based Immunity to Infection Tatsuya Saitoh, Osaka University, Japan Role of Atg14L1 in Autophagy and Immunity Short Talk Chosen from Abstracts WEDNESDAY, FEBRUARY 20 Autophagy and the Inlammasome Gkhan S. Hotamisligil, Harvard University, USA Metabolic Inlammasome Jenny P. Ting, University of North Carolina at Chapel Hill, USA Fatty Acid Regulation of the Inlammasome Augustine Choi, Harvard Medical School, USA Autophagy, Mitochondria and the Inlammasome Nobuhiko Kayagaki, Genentech, Inc., USA The Non-Canonical Inlammasome and Caspase 11 Short Talk(s) Chosen from Abstracts Autophagy and Inlammatory Signaling Masaaki Komatsu, Tokyo Metropolitan Institute of Medical Science, Japan Autophagy and the Nrf2-Keap 1 Pathway in Stress Response Jorge Moscat, Sanford-Burnham Medical Research Institute, USA p62: A Multifunctional Signaling Molecule in Cancer Metabolism Sergio Grinstein, Hospital for Sick Children, Canada PI3 Kinases and Reactive Oxygen Species in Phagosome Maturation Short Talk Chosen from Abstracts THURSDAY, FEBRUARY 21 Autophagy in Metabolic and Inlammatory Disease Mark J. Czaja, Albert Einstein College of Medicine, USA Autophagy and Lipid Metabolism Ramnik Xavier, Massachusetts General/Broad Institute, USA Autophagy Genes and Inlammatory Bowel Disease Lora V. Hooper, University of Texas Southwestern Medical Center, USA Intestinal Epithelial Cell Autophagy and the Microbiota Thaddeus S. Stappenbeck, Washington University School of Medicine, USA Autophagy Proteins and Regulation of Intestinal Inlammation Short Talk(s) Chosen from Abstracts Autophagy in Cell Death and Cancer Immunity Eileen P. White, Rutgers University, USA Autophagy in Tumor Cell Survival Guido Kroemer, Institut Gustave Roussy, France Autophagy-Dependent Anti-Tumor Immunity Speaker to be Announced Late-Breaking Research Short Talk Chosen from Abstracts FRIDAY, FEBRUARY 22: DEPARTURE
Invited, not yet accepted
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. Scientic Organizers: Herbert (Skip) W. Virgin IV, Beth Levine and Gkhan S. Hotamisligil Sponsored by Abbott Laboratories and Vertex Pharmaceuticals Incorporated 34 NUTRITION, EPIGENETICS AND HUMAN DISEASE FEBRUARY 1924, 2013 HILTON SANTA FE HISTORIC PLAZA HOTEL, SANTA FE, NEW MEXICO, USA (venue information on page 45) DEADLINES: ABSTRACT & SCHOLARSHIP OCT 17, 2012 LATE-BREAKING ABSTRACT NOV 19, 2012 DISCOUNTED REGISTRATION DEC 17, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13B5 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B5. Scientic Organizers: Robert A. Waterland, David S. Rosenblatt and Patrick J. Stover TUESDAY, FEBRUARY 19: ARRIVAL & REGISTRATION WEDNESDAY, FEBRUARY 20 Keynote Address Ezra S. Susser, Columbia University, USA The Developmental Origins of Neurodevelopmental Disorders Nutrition and Epigenetics in Development and Disease of the CNS Arthur L. Beaudet, Baylor College of Medicine, USA The Role of Epigenetics and Carnitine Metabolism in Autism Peng Jin, Emory University School of Medicine, USA Epigenetic Mechanisms in Neural Development and Disease Ryszard Maleszka, Australian National University, Australia Nutritional Regulation of Differential Methylation in Development and Behavior of Honeybees Short Talk(s) Chosen from Abstracts Nutrient Regulation of the Epigenetic Machinery Roderick Dashwood, Oregon State University, USA Mechanisms Underlying Non-Nutritive Bioactive Food Components and Histone Modiications Paolo Sassone-Corsi, University of California, Irvine, USA SIRT1: The Link between Energy Balance, Chromatin Remodeling and Circadian Physiology Speaker to be Announced Nutrient Regulation of DNA Methylase and Demethylase Activity THURSDAY, FEBRUARY 21 Nutrition and Epigenetics in Obesity Richard B. Simerly, Childrens Hospital Los Angeles, University of Southern California, USA Nutritional-Endocrine Interactions in Postnatal Hypothalamic Development Joseph H. Nadeau, Institute for Systems Biology, USA Ancestral Paternal Genotype Affects Body Weight and Food Intake Transgenerationally Short Talk(s) Chosen from Abstracts Robert A. Waterland, Baylor College of Medicine, USA Nutritional Inluences on Hypothalamic Developmental Epigenetics Speaker to be Announced Epigenetic Factors in Adipose Tissue Endocrine Dysregulation in Obesity Nutrient, Methyl Metabolism and Epigenetic Interactions David S. Rosenblatt, McGill University, Canada Discovering New Genes in the One Carbon Pathway Using Exome Sequencing Patrick J. Stover, Cornell University, USA Regulation of the Folate Metabolic Network during Mouse Development, and its Impact on Genome Methylation and Stability Rima Rozen, McGill University, Canada Impact of Genetic and Nutritional Variation in Folate Metabolism on Cellular Methylation Capacity FRIDAY, FEBRUARY 22 Nutrition and Developmental Epigenetics in the Endocrine Pancreas Miguel Constancia, University of Cambridge, UK Maternal Dietary Effects on Epigenetic Regulation of Enhancers in Pancreatic Islets Frans C. Schuit, Katholieke Universiteit Leuven, Belgium -Cell Speciic Epigenetic Repression of Disallowed Genes: Implications for Development and Disease Short Talk(s) Chosen from Abstracts Speaker to be Announced Epigenetic Mechanisms in Lipotoxicity in the Endocrine Pancreas Jorge Ferrer, Institut dInvestigacions Biomediques Auguts Pi i Sunyer (IDIBAPS), Spain Regulation of the Epigenome in Human Pancreatic Islet Cells Nutrients and Allelic Targeting of Epigenetic Signatures J. Kim Kemper, University of Illinois at Urbana-Champaign, USA Nuclear Receptor and Small Heterodimer Partner Recruitment of Chromatin Remodeling in the Regulation of Lipid and Glucose Metabolism Chen-Yu Zhang, Nanjing University, China Regulation of Human Gene Expression by Dietary miRNAs Speaker to be Announced siRNA Targeting of Genes for Site-Speciic Methylation SATURDAY, FEBRUARY 23 Nutritional Modulation of Stem Cell Programming Sir John B. Gurdon, University of Cambridge, UK Epigenetics and Nuclear Reprogramming by Eggs and Oocytes Yi Eve Sun, University of California, Los Angeles, USA Development Plasticity in Differentiation of Neural Stem Cells Implications for Development Programming Short Talk(s) Chosen from Abstracts Lanlan Shen, Baylor College of Medicine, USA Nutritional Inluences on Stem Cell Developmental Epigenetics in the Colonic Crypt Speaker to be Announced Epigenomic Analysis of Hematopoietic Stem Cells Undergoing Differentiation Present and Future: Pressing Issues in Environmental Epigenetics Jean-Pierre Issa, Temple University School of Medicine, USA Nutrition, Epigenetics and Cancer Andrew M. Prentice, London School of Hygiene and Tropical Medicine, UK Long-Term Consequences of Maternal and Child Nutrition in Developing Countries Scott F. Gilbert, Swarthmore College, USA The Global Environment and Ecological Developmental Biology SUNDAY, FEBRUARY 24: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 35 MYELOID CELLS: REGULATION AND INFLAMMATION FEBRUARY 1924, 2013 KEYSTONE RESORT, KEYSTONE, COLORADO, USA (venue information on page 45) DEADLINES: ABSTRACT & SCHOLARSHIP OCT 18, 2012 LATE-BREAKING ABSTRACT NOV 19, 2012 DISCOUNTED REGISTRATION DEC 17, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13B6 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B6. Scientic Organizers: Vincenzo Cerundolo, Gwendalyn J. Randolph and David M. Mosser TUESDAY, FEBRUARY 19: ARRIVAL & REGISTRATION WEDNESDAY, FEBRUARY 20 Keynote Address Siamon Gordon, University of Oxford, UK Pro- and Anti-Inlammatory Role of Myeloid Cells Myeloid Lineage Differentiation Irving L. Weissman, Stanford University, USA Differentiation of GMP into Granulocytes and Monocytes Paul S. Frenette, Albert Einstein College of Medicine, USA Mobilization from the Bone Marrow of Myeloid Cells Paresh Vyas, University of Oxford, UK Lineage Differentiation of AML Michael H. Sieweke, Centre dImmunologic Marseille-Luming, France Transcriptional Control of Myeloid Cell Fate and Self Renewal Short Talk Chosen from Abstracts Plasticity of Myeloid Cells David M. Mosser, University of Maryland, USA Macrophage Plasticity Vincenzo Cerundolo, University of Oxford, UK Plasticity of PMN in Cancer Judith E. Allen, University of Edinburgh, UK Local Macrophage Proliferation THURSDAY, FEBRUARY 21 Myeloid Cells during Inlammation Ajay Chawla, University of California, San Francisco, USA Monocyte Subsets and Metabolic Disease Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA Pathogens and Mucosal Immunity Christopher K. Glass, University of California, San Diego, USA A Genome-Wide View of Macrophage Activation Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany NETs From Infection to Autoimmunity Short Talk(s) Chosen from Abstracts Workshop 1: Inlammation and Chemokine Receptors Short Talks Chosen from Abstracts Myeloid Cell Migration and Traficking Gwendalyn J. Randolph, Washington University, USA Monocyte Migration Paul Kubes, University of Calgary, Faculty of Medicine, Canada Traficking of Neutrophils Frederic Geissmann, Kings College London, UK Inlammatory Monocytes FRIDAY, FEBRUARY 22 Signaling Events Luke A. J. ONeill, Trinity College Dublin, Ireland MicroRNAs in TLR Signaling Events Caetano Reis e Sousa, Cancer Research UK London Research Institute, UK Innate Immune Recognition of Cell Death Alan Aderem, Seattle BioMed, USA Innate Mechanisms for Intracellular Bacteric Jenny P. Ting, University of North Carolina at Chapel Hill, USA Inlammasomes Short Talk(s) Chosen from Abstracts Workshop 2: Myeloid Regulatory Cells Short Talks Chosen from Abstracts Myeloid Cells during Pathogen Infections Denise M. Monack, Stanford University, USA Inlammasome Activation and Bacterial Infections Bali Pulendran, Emory University, USA Immunlogical Signatures John Schoggins, Rockefeller University, USA Interferon Antiviral Responses SATURDAY, FEBRUARY 23 Myeloid Cells Modulating Adaptive Immune Responses Miriam Merad, Mount Sinai Medical Center, USA Cutaneous DC and T Cells Ronald N. Germain, NIAID, National Institutes of Health, USA Myeloid Cell Localization, Interactions and Traficking in Tissues Kenneth M. Murphy, Washington University School of Medicine, USA DC and Adaptive Immune Response Matteo Iannacone San Raffaele Scientiic Institute Italy Lymph Node Macrophages and Antiviral Immune Responses Short Talk(s) Chosen from Abstracts Myeloid Cells in Pathologies and in the Clinic Virginia Pascual, Baylor Institute for Immunology Research, USA Neutrophils and SLE Jeffrey W. Pollard, Albert Einstein College of Medicine, USA Macrophages and Tumor Progression Alan Sher, NIAID, National Institutes of Health, USA Talk Title to be Determined SUNDAY, FEBRUARY 24: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 36 STEM CELL REGULATION IN HOMEOSTASIS AND DISEASE FEBRUARY 24MARCH 1, 2013 FAIRMONT BANFF SPRINGS, BANFF, ALBERTA, CANADA (venue information on page 45) DEADLINES: ABSTRACT & SCHOLARSHIP OCT 24, 2012 LATE-BREAKING ABSTRACT NOV 27, 2012 DISCOUNTED REGISTRATION DEC 18, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13B7 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13B7. Scientic Organizers: Sean J. Morrison, Iannis Aifantis and Yukiko M. Yamashita SUNDAY, FEBRUARY 24: ARRIVAL & REGISTRATION MONDAY, FEBRUARY 25 Keynote Address George Q. Daley, Childrens Hospital Boston, USA Disease Modeling in iPS Cells Pluripotency and Disease Modeling Anjana Rao, La Jolla Institute for Allergy and Immunology, USA DNA Methylation, TET Proteins and Pluripotency Konrad Hochedlinger, Massachusetts General Hospital, USA Sox2(+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice Kathrin Plath, University of California, Los Angeles, USA Insights into Reprogramming Mechanisms Deepak Srivastava, Gladstone Institute of Cardiovascular Disease, USA Talk Title to be Determined Short Talk(s) Chosen from Abstracts Stem Cells and Regeneration Trista E. North, Beth Israel Deaconess Medical Center, USA Metabolic Regulation of Hematopoietic Stem Cell Formation Alejandro Snchez Alvarado, HHMI/Stowers Institute for Medical Research, USA Planaria David T. Scadden, MGH/Harvard University, USA The Pysiological Function of Mesenchymal Stem Cells Short Talk Chosen from Abstracts TUESDAY, FEBRUARY 26 Niche Regulation of Stem Cell Function Allan C. Spradling, HHMI/Carnegie Institute, USA Stem Cells and Tissue Homeostasis Valerie Horsley, Yale University, USA Skin Stem Cell Niche Fiona Doetsch, Columbia University, USA Stem Cells and their Niche in the Adult Mammalian Brain Sean J. Morrison, HHMI/University of Texas Southwestern Medical Center, USA Hematopoietic Stem Cell Niche Short Talk(s) Chosen from Abstracts Emerging Regulatory Mechanisms Iannis Aifantis, HHMI/New York University School of Medicine, USA E3 Ligases in HSC Differentiation K. J. Patel, MRC Laboratory of Molecular Biology, UK Mechanisms to Prevent DNA Damage by Metabolites in Stem Cells Yukiko M. Yamashita, University of Michigan, Ann Arbor, USA Cellular Polarity, Germline Stem Cell Maintenance and Aging Short Talk Chosen from Abstracts WEDNESDAY, FEBRUARY 27 RNA Regulation and Stem Cells Haifan Lin, Yale University, USA RNA Stability in Fly Stem Cells Robert H. Blelloch, University of California, San Francisco, USA MicroRNA Regulation of Pluripotency Richard Iain Gregory, Harvard Medical School, Childrens Hospital, USA Lin28, Let-7 and Stem Cells Judith E. Kimble, University of Wisconsin-Madison, USA Notch Signaling and an RNA Regulatory Network Control C. elegans Germline Stem Cells Short Talk(s) Chosen from Abstracts Stem Cells and Cancer Richard J. Gilbertson, St. Jude Childrens Research Hospital, USA Lineage Tracing in Normal Stem Cells and Cancer Austin Gurney, OncoMed Pharmaceuticals, USA Targeting Stem Cell Pathways in Cancer Luis F. Parada, University of Texas Southwestern Medical Center, USA Lineage Tracing in Brain Tumors Short Talk Chosen from Abstracts THURSDAY, FEBRUARY 28 The Aging of Mitotic Cells Andrew G. Dillin, The Salk Institute for Biological Studies, USA Protein Quality Control in Stem Cells and Aging Anne Brunet, Stanford University, USA The Regulation of Stem Cell Aging Manuel Serrano, Spanish National Cancer Center (CNIO), Spain Tumor Suppressors and Lifespan Norman E. Sharpless, University of North Carolina School of Medicine, USA Regeneration and Aging Short Talk(s) Chosen from Abstracts Self-Renewal Pathways and Disease Alexandra Joyner, Memorial Sloan-Kettering Institute, USA Sonic Hedgehog and the Regulation of Neural Stem Cells Frederic J. de Sauvage, Genentech, Inc., USA Targeting Sonic Hedgehog Signaling in Cancer Fernando D. Camargo, Childrens Hospital Boston, USA Hippo Signaling FRIDAY, MARCH 1: DEPARTURE
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 37 PI 3-KINASE AND INTERPLAY WITH OTHER SIGNALING PATHWAYS FEBRUARY 24MARCH 1, 2013 KEYSTONE RESORT, KEYSTONE, COLORADO, USA (venue information on page 45) Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X3. JOINT WITH... SUNDAY, FEBRUARY 24: ARRIVAL & REGISTRATION Keynote Session Kevan M. Shokat*, University of California, San Francisco, USA Jose Baselga*, Massachusetts General Hospital, USA Christian Rommel*, USA Peter K. Vogt, The Scripps Research Institute, USA Oncogenes in the PI3K Pathway Roger L. Williams, Medical Research Council, UK The PI3K Pathway by Protein Structures MONDAY, FEBRUARY 25 PI3K/Akt/mTOR Pathway in Cancer (Clinical Part 1) Jose Baselga*, Massachusetts General Hospital, USA Breast Cancer Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA Overcoming Resistance to Targeted Therapies Vito J. Palombella Ininity Phaimaceuticals Inc 0SA Development of Potent PI3K-/ Inhibitors Yardena Samuels, NHGRI, National Institutes of Health, USA Human Cancer Genetics Short Talk(s) Chosen from Abstracts PI3K/Akt/mTOR Pathway (Clinical Part 2) William R. Sellers*, Novartis Institutes for BioMedical Research, USA PI3K Kui Lin, Genentech, Inc, USA Akt Christian Rommel, USA TORC1/2 TUESDAY, FEBRUARY 26 PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational) Jeffrey Adam Engelman*, Massachusetts General Hospital, USA Resistance Mechanisms Sebastian Nijman, CeMM, Austria Resistance Mechanisms Lori Friedman*, Genentech, Inc., USA Combination Therapies Short Talk(s) Chosen from Abstracts PI3K/mTOR Pathway Signaling Networks (Preclinical) Kevan M. Shokat*, University of California, San Francisco, USA Polypharmacological Targeting of The P13K/mTOR and Raf/Mek Pathways of Cancer John Blenis, Harvard University Medical School, USA mTOR Complex 1, Metabolism and Cell Growth Control David M. Sabatini, Whitehead Institute for Biomedical Research, USA Regulation of Growth by the mTOR Pathway Short Talk Chosen from Abstracts WEDNESDAY, FEBRUARY 27 PI3K-Related Pathways (Preclinical) Lewis C. Cantley*, Harvard Medical School, USA PI3K and Cancer Metabolism Judith A. Varner, University of California, San Diego, USA PI3K Control of Innate Immunity in Cancer Karen M. Cichowski, Brigham and Women's Hospital, Harvard Medical School, USA Developing Combination Therapies with PI 3-K/mTOR Pathway Inhibitors Hong Wu, University of California, Los Angeles, USA Hormone Cross-Talk Signaling Short Talk(s) Chosen from Abstracts PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical) Christian Rommel*, USA Julian H. Downward, Cancer Research UK, UK Links between RAS Family GTPases and PI3K Signaling Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA Interplay Signaling Pier Paolo Pandoli, Beth Israel Deaconess Medical Center/Harvard Medical School, USA Talk Title to be Determined Short Talk Chosen from Abstracts THURSDAY, FEBRUARY 28 PI3K-Related Pathways (Preclinical) Bart Vanhaesebroeck*, Barts and The London School of Medicine, UK PI3K and Mitosis Davide Ruggero, University of California, San Francisco, USA Ribosome Signaling Jonathan Hart, The Scripps Research Institute, USA PI3K/mTOR/STAT Signaling William A. Weiss, University of California, San Francisco, USA Autophagy Short Talk(s) Chosen from Abstracts PI3K-Related Pathways (Preclinical) David A. Fruman, University of California, Irvine, USA Mechanism of mTOR Inhibitor Action in Lymphocytes Brendan D. Manning, Harvard School of Public Health, USA The TSC-mTOR Network in Cancer and Metabolism Ramon Parsons, Columbia University, USA PTEN Signaling FRIDAY, MARCH 1: DEPARTURE *Session Chair This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 38 Scientic Organizers: Christian Rommel, Kevan M. Shokat and Jose Baselga Sponsored by Bayer USA Foundation, Gilead Sciences, Inc. and Innity Pharmaceuticals TUMOR METABOLISM Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X4. DEADLINES FOR BOTH CONFERENCES: ABSTRACT & SCHOLARSHIP OCT 25, 2012 LATE-BREAKING ABSTRACT NOV 28, 2012 DISCOUNTED REGISTRATION DEC 19, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13X3 or /13X4 Scientic Organizers: Matthew G. Vander Heiden and Karen H. Vousden Sponsored by Bayer USA Foundation Registering for one conference in a set of joint conferences enables participation in sessions of the other, pending space availability. SUNDAY, FEBRUARY 24: ARRIVAL & REGISTRATION MONDAY, FEBRUARY 25 Keynote Address Craig B. Thompson, Memorial Sloan-Kettering Cancer Center, USA Metabolic Control of Tumor Cell Growth and Survival Metabolic Regulation Almut Schulze, Cancer Research UK, UK The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells Sally A. Kornbluth, Duke University Medical Center, USA Metabolic Control of Cell Physiology Linda Z. Penn, Ontario Cancer Institute, Canada Understanding and Exploiting the Oncogenic Capacity of the Mevalonate Pathway Short Talk(s) Chosen from Abstracts Nutrient Sensing Eileen P. White, Rutgers University, USA Autophagy as a Response to Nutrient Deprivation Reuben J. Shaw, The Salk Institute, USA Signaling Events to Cope with Energy Stress David M. Sabatini, Whitehead Institute for Biomedical Research, USA Amino Acid Sensing Mechanisms TUESDAY, FEBRUARY 26 Metabolic Adaptation Chi Van Dang, University of Pennsylvania, USA Glutamine and Cellular Energetics Karen H. Vousden, Beatson Institute for Cancer Research, UK Metabolic Adaptation Controlled by p53 Eyal Gottlieb, Beatson Institute for Cancer Research, UK Revealing New Metabolic Networks in Cancer Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA Metabolic Pathways Important for Cell Growth Short Talk(s) Chosen from Abstracts Understanding the Metabolic Network Eytan Ruppin, Tel Aviv University, Israel Harnessing Genome-Scale Metabolic Modeling to Study Cancer Metabolism Joshua D. Rabinowitz, Princeton University, USA Measuring Metabolic Flux Benjamin F. Cravatt III, The Scripps Research Institute, USA Functional Enzyme Characterization WEDNESDAY, FEBRUARY 27 Inluence of the Microenvironment on Metabolism Jacques Pouyssgur, University of Nice, France Role of Oxygen in Controlling Cancer Metabolism M. Celeste Simon, University of Pennsylvania, USA Tumor Cell Adaptation to the Microenvironment Amato J. Giaccia, Stanford University, USA Oxygen Sensing and Metabolic Control Salvador Moncada, University College London, UK Sensing the Microenvironment to Inluence Metabolism Short Talk(s) Chosen from Abstracts Insights from in vivo Experiments Tak W. Mak, Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital, UHN, Canada Tumor Metabolism Insight from Mouse Models Yanping Zhang, University of North Carolina at Chapel Hill, USA Ribosomal Protein-Mdm2-p53 Signaling and Energy Metabolism Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA Measuring Metabolism and Metabolites in vivo Speaker to be Announced Imaging Glutamine Metabolism in Patient Tumors Using PET THURSDAY, FEBRUARY 28 Targeting Metabolism Bing Lim, Genome Institute of Singapore, Singapore Targeting Glycine Metabolism for Cancer Therapy Speaker to be Announced Targeting Fatty Acid Metabolism Susan Critchlow, AstraZeneca, UK Targeting Lactate Metabolism Joan S. Brugge, Harvard Medical School, USA Use of 3D Culture Models to Understand the Impact of Targeted Therapy on Metabolism Short Talk(s) Chosen from Abstracts Inluence of Metabolism on Epigenetic Regulation Yue Xiong, University of North Carolina at Chapel Hill, USA Inluence of Metabolism on Signal Transduction Kathryn E. Wellen, University of Pennsylvania, USA Use of Metabolic Pathways to Sense Cell State Katherine Yen, Agios Pharmaceuticals, USA Inluence of IDH Mutations on the Epigenetic State of Cells FRIDAY, MARCH 1: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 39 STRUCTURAL ANALYSIS OF SUPRAMOLECULAR ASSEMBLIES BY HYBRID METHODS MARCH 37, 2013 GRANLIBAKKEN RESORT, TAHOE CITY, CALIFORNIA, USA (venue information on page 27) DEADLINES: ABSTRACT & SCHOLARSHIP NOV 5, 2012 LATE-BREAKING ABSTRACT DEC 3, 2012 DISCOUNTED REGISTRATION DEC 19, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13C1 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C1. Scientic Organizers: Andrej Sali, Brian T. Chait and David Baker SUNDAY, MARCH 3: ARRIVAL & REGISTRATION MONDAY, MARCH 4 Keynote Address Robert T. Tjian, HHMI/University of California, Berkeley, USA Integrative Approaches to Studying the Cell Computation for Hybrid Approaches Andrej Sali, University of California, San Francisco, USA Integrative Structure Determination of Macromolecular Assemblies David Baker, University of Washington, USA Hybrid Methods for Atomic Structure Determination Gregory A. Voth, University of Chicago, USA Multi-Scale Models of Biological Macromolecules Zaida (Zan) Luthey-Schulten, University of Illinois at Urbana- Champaign, USA Whole Cell Simulations Short Talk Chosen from Abstracts Hybrid Approaches to Studying Dynamic Systems James R. Williamson, The Scripps Research Institute, USA Hybrid Studies of Ribosome Assembly in Cells Joseph D. Puglisi, Stanford University, USA Hybrid Studies of the Ribosome Function Klaus Schulten, University of Illinois at Urbana-Champaign, USA Simulation of Dynamics of Large Macromolecular Systems Short Talk Chosen from Abstracts TUESDAY, MARCH 5 Hybrid Approaches to Studying Macromolecular Structures Ian A. Wilson, The Scripps Research Institute, USA Hybrid Approaches to Antibody Virus Systems Holger Stark, Max Planck Institute for Biophysical Chemistry, Germany Hybrid Structural Studies of the Splicing Machinery Wolfgang P. Baumeister, Max Planck Institute of Biochemistry, Germany Hybrid Studies of the Structure and Function of the 26S Proteasome David A. Agard, University of California, San Francisco, USA Hybrid Approaches to Tubulin Assembly Short Talk(s) Chosen from Abstracts Workshop and Panel 1: Key Bottlenecks in Hybrid Method Development Short Talks Chosen from Abstracts Hybrid Approaches to Studying Cellular Organization Benjamin Geiger, Weizmann Institute of Science, Israel Talk Title to be Determined Frank Alber, University of Southern California, USA Genome Organization by Integrative Structure Determination Graham Johnson, University of California, San Francisco, USA Modeling and Animating the Cellular Mesoscale Short Talk Chosen from Abstracts WEDNESDAY, MARCH 6 Single Molecule Methods Stefan W. Hell, Max Planck Institute for Biophysical Chemistry, Germany Nanoscopy with Focused Light Jennifer A. Lippincott-Schwartz, NICHD, National Institutes of Health, USA Use of Photoactivated Localization Microscopy (PALM for High-Density Mapping of Single Molecules and their Trajectories at the Nanoscale Scott C. Blanchard, Weill Cornell Medical College, USA Single-Molecule Imaging of Biological Systems X. Sunney Xie, Harvard University, USA Single Molecule Enzymology Short Talk(s) Chosen from Abstracts Workshop and Panel 2: Latest Advances in Hybrid Methods Short Talks Chosen from Abstracts Latest Advances in Hybrid Methods Brian T. Chait, Rockefeller University, USA Mass Spectrometry and Proteomics for Hybrid Structure Determination Carolyn A. Larabell, University of California, San Francisco, USA X-Ray Tomography of Cells Michael Nilges, Institut Pasteur, France Inferential Structure Determination Short Talk Chosen from Abstracts THURSDAY, MARCH 7: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 40 UNDERSTANDING DENDRITIC CELL BIOLOGY TO ADVANCE DISEASE THERAPIES MARCH 38, 2013 KEYSTONE RESORT, KEYSTONE, COLORADO, USA (venue information on page 45) DEADLINES: ABSTRACT & SCHOLARSHIP NOV 6, 2012 LATE-BREAKING ABSTRACT DEC 3, 2012 DISCOUNTED REGISTRATION DEC 20, 2012 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13C2 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C2. Scientic Organizers: Miriam Merad and Bart N. Lambrecht SUNDAY, MARCH 3: ARRIVAL & REGISTRATION MONDAY, MARCH 4 Keynote Address Michel C. Nussenzweig, Rockefeller University, USA Ralph Steinman and the Dendritic Cell Discovery Development of Tissue-Resident and Inlammatory DC Miriam Merad*, Mount Sinai Medical Center, USA The DC Lineage Boris Reizis, Columbia University, USA Regulation of DC and PDC Development Bernard Malissen, Centre dImmunologie de Marseille-Luminy, France Transcriptional Proiling of DC Subsets Kenneth M. Murphy*, Washington University School of Medicine, USA Transcriptional Control of DC Development Short Talk Chosen from Abstracts Workshop 1: DC and Macrophage Genomics Bernard Malissen*, Centre dImmunologie de Marseille-Luminy, France Short Talks Chosen from Abstracts Transcriptional Control of DC Development and Function Hideki Ueno, Baylor Institute for Immunology Research, USA Functional Specialization of Human DC Subsets Nir Hacohen, Massachusetts General Hospital, USA Regulatory Networks Underlying Dendritic Cell Activation Bali Pulendran*, Emory University, USA Systems Analysis of Immune Response in Humans Short Talk Chosen from Abstracts TUESDAY, MARCH 5 Cell Biology and Antigen Processing Bart N. Lambrecht*, Ghent University, Belgium ER Stress and DC Function Averil I. Ma, University of California, San Francisco, USA Ubiquitination and DC Function Sebastian Amigorena*, Institut Curie, France Control of Antigen Presentatation by Human DC Akiko Iwasaki
, Yale University School of Medicine, USA
Autophagy and Antigen Presentation Short Talk(s) to be Announced Workshop 2: Regulation of DC Function Peter T. Lee*, Cell Press, USA Caetano Reis e Sousa*, Cancer Research UK London Research Institute, UK Short Talks Chosen from Abstracts Molecular and Functional Aspects of DC Migration Speaker to be Announced Reinhold Frster, Hannover Medical School, Germany Intranodal Behavior of DC Michael Sixt, Institute of Science and Technology Austria, Austria Cytoskeletal Dynamics of Dendritic Cells Short Talk Chosen from Abstracts WEDNESDAY, MARCH 6 DC Sensing of the Environment Eicke Latz, Institute of Innate Immunity, Bonn University, Germany Inlammasome Activation in Macrophages and DC Monsef Benkirane, Institut de Genetique Humaine, France DC HIV Interaction Caetano Reis e Sousa*, Cancer Research UK London Research Institute, UK Cell Death Receptors for Cross-Presentation Laurence Zitvogel*, Institut Gustave Roussy, France DC Sensing of Cell Death Short Talk(s) Chosen from Abstracts Role of PDC in Immunity and Disease Yong-Jun Liu*, Baylor Research Institute, USA DNA Sensors in PDC Marco Colonna, Washington University School of Medicine, USA PDC in Host Defense Toshiaki Ohteki, Tokyo Medical and Dental University, Japan PDC Control of Mucosal Immunity Short Talk Chosen from Abstracts THURSDAY, MARCH 7 Role of DC in Pathogenesis Speaker to be Announced William R. Heath*, University of Melbourne, Australia DC Control of Viral Immunity Steffen Jung*, Weizmann Institute of Science, Israel Control of Mucosal Immunity by DCs and Macrophages Hamida Hammad, Ghent University, Belgium Role of Dendritic Cells in the Pathogenesis of Asthma Short Talk(s) Chosen from Abstracts Workshop 3: Role of DC in Pathogenesis Zoltan Fehervari*, Nature Publishing Group, UK Short Talks Chosen from Abstracts Harnessing DC Biology to Advance Disease Therapies Bana Jabri, University of Chicago, USA DC in Celiac Disease Franck J. Barrat*, Dynavax Technologies, USA DC Control of Autoimmunity A. Karolina Palucka, Baylor Institute for Immunology Research, USA DC Vaccine and Target Against Cancer Concluding Remarks Ira Mellman, Genentech, Inc., USA Translating DC Biology into Medicine FRIDAY, MARCH 8: DEPARTURE *Session Chair
Invited, not yet accepted
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or a workshop. 41 DNA REPLICATION AND RECOMBINATION MARCH 38, 2013 FAIRMONT BANFF SPRINGS, BANFF, ALBERTA, CANADA (venue information on page 45) Scientic Organizers: James M. Berger, Wolf-Dietrich Heyer and Julia Promisel Cooper Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X5. JOINT WITH... SUNDAY, MARCH 3: ARRIVAL & REGISTRATION Keynote Session (Joint) Frederick W. Alt, HHMI/Childrens Hospital Boston and Immune Disease Institute, USA Mechanisms of Normal and Aberrant Recombination and Repair Processes in Lymphocytes Kenneth J. Marians, Memorial Sloan-Kettering Cancer Center, USA Mechanisms of Replication Restart MONDAY, MARCH 4 Mechanisms and Control of DNA Repair/Mechanisms of Homologous Recombination (Joint) Stephen C. Kowalczykowski, University of California, Davis, USA Single-Molecule Analysis of Recombination Maria Jasin, Memorial Sloan-Kettering Cancer Center, USA Control of DNA Repair by BRCA1 and BRCA2 Wolf-Dietrich Heyer, University of California, Davis, USA Mechanisms of Regulating Recombination Roland Kanaar, Erasmus University, Netherlands Mechanism and Control of Homologous Recombination Short Talk(s) Chosen from Abstracts Workshop 1: Regulation of DNA Superstructure Short Talks Chosen from Abstracts Postreplication Repair/Restart Johannes C. Walter, Harvard Medical School, USA The Mechanism of Replication-Coupled DNA Interstrand Cross-Link Repair James E. Haber, Brandeis University, USA Repair of Broken Yeast Chromosomes by Recombination Wei Yang, NIDDK, National Institutes of Health, USA Repair Polymerase Mechanisms Short Talk Chosen from Abstracts TUESDAY, MARCH 5 Replication Initiation Strategies across Species Stephen P. Bell*, Massachusetts Institute of Technology, USA Activation of the Eukaryotic Replicative DNA Helicase Terry L. Orr-Weaver, Massachusetts Institute of Technology, USA Changes in Gene Copy Number as a Developmental Strategy and DNA Replication Model Leemor Joshua-Tor, Cold Spring Harbor Laboratory, USA Viral Initiation Mechanisns James M. Berger, University of California, Berkeley, USA Bacterial Initiation Mechanisms Short Talk(s) Chosen from Abstracts Workshop 2: DNA Repair Processes Short Talks Chosen from Abstracts Workshop 3: DNA Replication Processes Short Talks Chosen from Abstracts Replication, Chromatin and Genome Instability (Joint) Genevive Almouzni Centie National ue la Recheiche Scientiique Fiance Recombinational Repair and Heterochromatin Ian D. Hickson, University of Copenhagen, Denmark Processing of Late Replication Intermediates Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland Chromatin, DNA Damage and DNA Replication Short Talk Chosen from Abstracts WEDNESDAY, MARCH 6 Genome Structure and Maintenance Lorraine S. Symington*, Columbia University, USA Control of Crossover Formation Simon J. Boulton*, London Research Institute, Clare Hall Laboratories, UK Genome Stability and the Regulation of Recombination Stephen C. West, Cancer Research UK, UK Making and Breaking Recombination Intermediates Richard D. Kolodner, Ludwig Institute for Cancer Research, USA Mechanisms of Gross Chromosomal Rearrangements Short Talk(s) Chosen from Abstracts Topological Transformations in DNA Phoebe Rice*, University of Chicago, USA Structure and Function of Site-Speciic Resolvases Camilla Sjgren, Karolinska Institutet, Sweden Regulation of DNA Topology Claire Wyman, Erasmus Medical Center, Netherlands Single-Molecule Analysis of DNA Pairing Short Talk Chosen from Abstracts THURSDAY, MARCH 7 Replication Elongation Machineries David J. Sherratt, University of Oxford, UK High-Resolution in vivo Analysis of Bacterial Chromosome Replication and Recombination Peter M. Burgers*, Washington University School of Medicine, USA Structure and Fidelity of DNA Polymerases at the Replication Fork Stephen D. Bell, University of Oxford, UK Archaeal DNA Replication Linda B. Bloom, University of Florida, USA Clamp Loading Mechanisms Short Talk(s) Chosen from Abstracts Workshop 4: Enzymes Acting on Nucleic Acids (Joint) Short Talks Chosen from Abstracts Replicating Challenging Regions Julia Promisel Cooper, London Research Institute, UK Coordination of Telomeric Replication Fork Passage and Telomerase Activity Virginia A. Zakian*, Princeton University, USA Helicases that Promote Fork Progression Joachim Lingner, EPFL, Switzerland Telomeres and the Regulation of Telomerase Short Talk Chosen from Abstracts FRIDAY, MARCH 8: DEPARTURE *Session Chair This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 42 GENOMIC INSTABILITY AND DNA REPAIR Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X6. DEADLINES FOR BOTH CONFERENCES: ABSTRACT & SCHOLARSHIP NOV 7, 2012 LATE-BREAKING ABSTRACT DEC 4, 2012 DISCOUNTED REGISTRATION JAN 7, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13X5 or /13X6 Scientic Organizers: Stephen P. Jackson, Alan D. DAndrea and Susan M. Gasser Registering for one conference in a set of joint conferences enables participation in sessions of the other, pending space availability. SUNDAY, MARCH 3: ARRIVAL & REGISTRATION Keynote Session (Joint) Frederick W. Alt, HHMI/Childrens Hospital Boston and Immune Disease Institute, USA Mechanisms of Normal and Aberrant Recombination and Repair Processes in Lymphocytes Kenneth J. Marians, Memorial Sloan-Kettering Cancer Center, USA Mechanisms of Replication Restart MONDAY, MARCH 4 Mechanisms and Control of DNA Repair/Mechanisms of Homologous Recombination (Joint) Stephen C. Kowalczykowski, University of California, Davis, USA Single-Molecule Analysis of Recombination Maria Jasin, Memorial Sloan-Kettering Cancer Center, USA Control of DNA Repair by BRCA1 and BRCA2 Wolf-Dietrich Heyer, University of California, Davis, USA Mechanisms of Regulating Recombination Roland Kanaar, Erasmus University, Netherlands Mechanism and Control of Homologous Recombination Short Talk(s) Chosen from Abstracts Chromosomal Stability, Instability and Nuclear Architecture Jiri Lukas, Danish Cancer Society, Denmark DNA Repair and Chromosomal Fragility Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology, France Nuclear Architecture and Responses to DNA Damage Speaker to be Announced Short Talk Chosen from Abstracts TUESDAY, MARCH 5 Controlling DNA Damage Responses by Ubiquitylation and Sumoylation Daniel Durocher, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada Ubiquitylation Control of Double-Strand Break Responses Stephen P. Jackson, University of Cambridge, UK Assembly and Disassembly of DNA Repair Complexes by Regulated Ubiquitylation Dana Branzei, FIRC Institute of Molecular Oncology, Italy Sumoylation at the DNA Replication Fork Alan D. DAndrea, Dana-Farber Cancer Institute, USA Fanconi Anemia Pathway and its Control by Ubiquitylation Short Talk(s) Chosen from Abstracts Workshop 1: DNA-Damage Checkpoint Signaling Short Talks Chosen from Abstracts Replication, Chromatin and Genome Instability (Joint) Genevive Almouzni Centie National ue la Recheiche Scientiique Fiance Recombinational Repair and Heterochromatin Ian D. Hickson, University of Copenhagen, Denmark Processing of Late Replication Intermediates Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland Chromatin, DNA Damage and DNA Replication Short Talk Chosen from Abstracts WEDNESDAY, MARCH 6 Genome Instability, Telomeres, Disease and Aging Titia de Lange, Rockefeller University, USA Telomeres and Responses to DNA Damage Jan H. J. Hoeijmakers, Erasmus, Netherlands The Central Role of DNA in Cancer, Aging and Longevity Laura J. Niedernhofer, University of Pittsburgh Cancer Institute, USA XPF and its Links to Cancer and Aging Keith W. Caldecott, University of Sussex, UK DNA Repair Defects Associated with Neurodegenerative Diseases Short Talk(s) Chosen from Abstracts DNA Damage and Links to Transcription, RNA Metabolism and Other Processes Andrs Aguilera, Andalusian Molecular Biology and Regenerative Medicine Centre, Spain Transcription-Induced DNA Damage and Recombination Michael B. Yaffe, Massachusetts Institute of Technology, USA RNA and RNA Binding Proteins in the DNA Damage Response Karlene A. Cimprich, Stanford University, USA Transcription-Induced Genome Instability Short Talk Chosen from Abstracts THURSDAY, MARCH 7 Genomic and Genome-Wide Studies Michael Stratton, Wellcome Trust Sanger Institute, UK Genome Instability in Cancer David Cortez, Vanderbilt University Medical Center, USA Identiication and Characterization of Mammalian Genome Maintenance Proteins Marcel Tijsterman, Leiden University Medical Center, Netherlands C. elegans Screens for Genome Instability and DNA Repair Factors Trey Ideker, University of California, San Diego, USA A Conserved Map of Genetic Interactions Induced by DNA Damage Short Talk(s) Chosen from Abstracts Workshop 2: Enzymes Acting on Nucleic Acids (Joint) Short Talks Chosen from Abstracts Diagnostic and Therapeutic Applications Thomas Helleday, Karolinska Institutet, Sweden Therapeutic Strategies for Cancer Based on DNA Repair Inhibition Jos Jonkers, Netherlands Cancer Institute, Netherlands DDR-Based Therapeutic Strategies and Resistance Mechanisms scar Fernndez-Capetillo, Centro Nacional de Investigaciones Oncologicas, Spain Targeting Oncogene-Induced Replication Stress for Cancer Therapy Short Talk Chosen from Abstracts FRIDAY, MARCH 8: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 43 GROWING TO EXTREMES: CELL BIOLOGY AND PATHOLOGY OF AXONS MARCH 1015, 2013 GRANLIBAKKEN RESORT, TAHOE CITY, CALIFORNIA, USA (venue information on page 27) DEADLINES: ABSTRACT & SCHOLARSHIP NOV 8, 2012 LATE-BREAKING ABSTRACT DEC 10, 2012 DISCOUNTED REGISTRATION JAN 10, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13C4 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C4. Scientic Organizers: Valeria Cavalli, Michael Fainzilber and Jeffery L. Twiss SUNDAY, MARCH 10: ARRIVAL & REGISTRATION MONDAY, MARCH 11 Axonal Speciication, Cytoskeleton and Compartmentalization Frank Bradke, German Center for Neurodegenerative Diseases, Germany Intracellular Mechanisms of Axonal Growth and Regeneration Matthew N. Rasband, Baylor College of Medicine, USA The Axon Initial Segment and the Maintenance of Neuronal Polarity Franck Polleux, The Scripps Research Institute, USA Molecular Mechanisms Specifying Cortical Neuron Polarity in vivo Kozo Kaibuchi, Nagoya University Graduate School of Medicine, Japan Neuronal Polarity in vitro and in vivo Short Talk(s) Chosen from Abstracts Axonal Growth Modalities Michael Fainzilber, Weizmann Institute of Science, Israel Motor-Driven Frequency-Based Mechanisms for Axon Growth Control Douglas H. Smith, University of Pennsylvania, USA The Role of Dynamic Stretch Injury in Growth and Degeneration Britta J. Eickholt, Charit Universittsmedizin Berlin, Germany Talk Title to be Determined Short Talk Chosen from Abstracts TUESDAY, MARCH 12 Molecular Motors and Axonal Transport Regulation Richard Vallee, Columbia University, USA Regulation of Cytoplasmic Dynein Motor Function Erika Holzbaur, University of Pennsylvania, USA Regulation of Dynein-Dependent Retrograde Transport in Health and Disease Models Valeria Cavalli, Washington University, USA Kinesin-1-Dependent Transport in Axon Growth and Regeneration Frdric Saudou, Institut Curie, France Role of Huntingtin in Vesicular Traficking along Axons Short Talk(s) Chosen from Abstracts Workshop Short Talks Chosen from Abstracts Axonal Membrane Dynamics and Organelle Transport Giampietro Schiavo, London Research Institute, UK In vivo Imaging of Axonal Transport in Health and Disease Rejji Kuruvilla, Johns Hopkins University, USA Regulation of Neuronal Development by Traficking of Neurotrophins and their Receptors Thomas L. Schwarz, Childrens Hospital Boston and Harvard Medical School, USA Regulating Mitochondrial Movement along Axons in Health and Disease Short Talk Chosen from Abstracts WEDNESDAY, MARCH 13 RNA Targeting and Local Translation Jeffery L. Twiss, Drexel University, USA mRNAs Compete for Limited Quantities of Transport Machinery Antonella Riccio, University College London, UK Neurotrophin-Dependent RNA Transport in Axons James Fawcett, University of Cambridge, UK Developmental Regulation of the Axonal mRNA Repertoire Mustafa Sahin, Childrens Hospital Boston, USA TSC-mTOR Signaling Regulates Axonal mRNA Translation Short Talk(s) Chosen from Abstracts Axonal Signaling David G. Ginty, Johns Hopkins University School of Medicine, USA Organization and Development of Neurons that Underlie the Sense of Touch Gary R. Lewin, Max Delbrck Center for Molecular Medicine, Germany Signaling Touch and Pain in the Peripheral Nervous System Mark H. Tuszynski, University of California, San Diego, USA From Neuronal Signaling to Axon Regeneration Short Talk Chosen from Abstracts THURSDAY, MARCH 14 Axonal Maintenance Christine Beattie, Ohio State University, USA Mechanisms of Motoneuron Dysfunction from Zebraish to Humans Avraham Yaron, Weizmann Institute of Science, Israel Mechanisms of Axonal Maintenance and Degeneration Joe Lewcock, Genentech, Inc., USA Intracellular Pathways that Underlie Neurodegeneration in Development and Disease Guo-li Ming, Johns Hopkins University, USA Talk Title to be Determined Short Talk(s) Chosen from Abstracts Axon-Glia Interactions Klaus-Armin Nave, Max Planck Institute of Experimental Medicine, Germany The Role of Glia in Axonal Development and Maintenance Bruce D. Carter, Vanderbilt University School of Medicine, USA Molecular Mechanisms of Peripheral Myelin Formation Short Talk Chosen from Abstracts Closing Keynote Address Martin E. Schwab, University of Zurich, Switzerland Axon Growth and Regeneration, from Basic to Clinic FRIDAY, MARCH 15: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 44 KEYSTONE RESORT KEYSTONE, COLORADO, USA FAIRMONT THE QUEEN ELIZABETH MONTREAL, QUEBEC, CANADA HILTON SANTA FE HISTORIC PLAZA HOTEL SANTA FE, NEW MEXICO, USA Local elevation: 9280 (2828 m) Local airport/distance to venue: Denver International (DEN)/ 90 mi (145 km) Local elevation: 130 (40 m) Local airport/distance to venue: Montreal-Pierre Elliott Trudeau International (YUL)/12 mi (19 km) Local elevation: 7000 (2134 m) Local airports/distances to venue: Albuquerque International Sunport ABQ mi km Santa Fe Nunicipal SAF mi km FAIRMONT BANFF SPRINGS BANFF, ALBERTA, CANADA Local elevation: 4593 (1400 m) Local airport/distance to venue: Calgary International (YYC)/ 90 mi (144 km) WHISTLER CONFERENCE CENTRE WHISTLER, BRITISH COLUMBIA, CANADA Local elevation: 2200 (671 m) Local airport/distance to venue: Vancouver International (YVR)/ 70 mi (115 km) ELDORADO HOTEL & SPA SANTA FE, NEW MEXICO, USA Local elevation: 7000 (2134 m) Local airports/distances to venue: Albuquerque International Sunport ABQ mi km Santa Fe Nunicipal SAF mi km 45 HOST RESPONSE IN TUBERCULOSIS MARCH 1318, 2013 WHISTLER CONFERENCE CENTRE, WHISTLER, BRITISH COLUMBIA, CANADA (venue information on page 45) Scientic Organizers: Andrea M. Cooper and Robert J. Wilkinson Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X7. JOINT WITH... WEDNESDAY, MARCH 13: ARRIVAL & REGISTRATION THURSDAY, MARCH 14 How Do Innate Cells Respond to Mtb (I) Larry S. Schlesinger, Ohio State University, USA Early Lung Responses Jennifer Philips, New York University School of Medicine, USA EsxH ESCRTs TB to Safety by Arresting Phagosome Maturation Speaker to be Announced Short Talks Chosen from Abstracts Keynote Address TB: The Continuing Challenge (Joint) Chris Dye, World Health Organization, Switzerland Population Dynamics and Control of Tuberculosis How Do Innate Cells Respond to Mtb (II) (Joint) Carl F. Nathan, Weill Cornell Medical College, USA Mtb Needs a Strong Host Immune Response But Not Too Strong: Mechanisms of Mycobacterial Immunomodulation Anne OGarra, MRC National Institute for Medical Research, UK Immune Responses in Tuberculosis: From Mouse Models to Human Disease David G. Russell, Cornell University, USA Intracellular Survival by Mycobacterium: No Pressure! FRIDAY, MARCH 15 Acquired Immunity Beyond the CD4 T Cell/ Macrophage Paradigm? Peter Andersen, Statens Serum Institut, Denmark Vaccine-Induced Protection Samuel M. Behar, Brigham and Womens Hospital, USA CD8 T Cells in TB Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA Innate and Acquired Response to Pathogenic Organisms Short Talks Chosen from Abstracts Workshop 1: Host Short Talks Chosen from Abstracts Vaccination Against Mtb (Joint) Daniel A. Portnoy, University of California, Berkeley, USA Vaccines for Intracellular Pathogens Thomas G. Evans, Aeras Global TB Vaccine Foundation, USA Early Results of Vaccine Trials in Humans Stefan H.E. Kaufmann, Max Planck Institute for Infection Biology-Berlin, Germany Current Vaccines SATURDAY, MARCH 16 The Consequences of the Immune Response in the Lung Denise Kirschner, University of Michigan, USA A Systems Biology Approach to Uncovering Mechanisms Governing Host-Mycobacterial Interactions during TB Infection Jon Friedland, Imperial College London, UK Matrix Metalloproteinases in TB Clifton E. Barry III, NIAID, National Institutes of Health, USA The Dynamics of Human Tuberculosis Short Talks Chosen from Abstracts Workshop 2: Bacteria Short Talks Chosen from Abstracts A Global View of Infection (Joint) Sebastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland Evolution of TB Speaker to be Announced Kanury V. S. Rao, International Centre for Genetic Engineering and Biotechnology, India Host Factors in Resistance SUNDAY, MARCH 17 Tuberculosis and HIV Robert J. Wilkinson, University of Cape Town, South Africa The Effect of HIV-1 Infection on the Human Immune Response to Mycobacterium tuberculosis JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA Modeling HIV-TB Immune Interaction in Non-Human Primates Daniel L. Barber, NIAID, National Institutes of Health, USA Experimental Models of Pathogenic Immune Restoration in Tuberculosis Richard A. Koup, NIAID, National Institutes of Health, USA HIV-Tuberculosis Interaction Short Talk(s) Chosen from Abstracts Host Susceptibility to Disease (Joint) Hardy Kornfeld, University of Massachusetts Medical School, USA Diabetes and TB Erwin Schurr, Montreal General Hospital, McGill University, Canada Host Susceptibility to Mtb Jean-Laurent Casanova, Rockefeller University, USA Mendelian Susceptibilty to Mycobacteria MONDAY, MARCH 18: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 46 TUBERCULOSIS: UNDERSTANDING THE ENEMY Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13X8. DEADLINES FOR BOTH CONFERENCES: GLOBAL HEALTH TRAVEL AWARD OCT 16, 2012 ABSTRACT & SCHOLARSHIP NOV 13, 2012 LATE-BREAKING ABSTRACT DEC 11, 2012 DISCOUNTED REGISTRATION JAN 14, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13X7 or /13X8 Scientic Organizers: Eric J. Rubin, Sebastien Gagneux and Heran Darwin Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation Registering for one conference in a set of joint conferences enables participation in sessions of the other, pending space availability. WEDNESDAY, MARCH 13: ARRIVAL & REGISTRATION THURSDAY, MARCH 14 Mycobacterium tuberculosis From Single Cells to Systems John D. McKinney, cole Polytechnique Fdrale de Lausanne, Switzerland Single Cell Division Cycle Dynamics and Stress Responses Veronique Anne Dartois, Novartis Institute of Tropical Diseases, Singapore Pharmacology, from Single Cells to Organisms Johnjoe McFadden, University of Surrey, UK Systems-Based Metabolic Analysis of Intracellular Growth Short Talks Chosen from Abstracts Keynote Address TB: The Continuing Challenge (Joint) Chris Dye, World Health Organization, Switzerland Population Dynamics and Control of Tuberculosis How Do Innate Cells Respond to Mtb (II) (Joint) Carl F. Nathan, Weill Cornell Medical College, USA Mtb Needs a Strong Host Immune Response But Not Too Strong: Mechanisms of Mycobacterial Immunomodulation Anne OGarra, MRC National Institute for Medical Research, UK Immune Responses in Tuberculosis: From Mouse Models to Human Disease David G. Russell, Cornell University, USA Intracellular Survival by Mycobacterium: No Pressure! FRIDAY, MARCH 15 Mycobacterial Diversity and Disease Nico C. Gey van Pittius, University of Stellenbosch, South Africa Evolution of the PE/PPE Proteins in Mycobacteria Thomas Ioerger, Texas A&M University, USA What Comparative Genomics of Mycobacteria Can Tell Us About Drug Resistance Jeffery S. Cox, University of California, San Francisco, USA Toxin-Anti-Toxin Systems and Persistence Short Talks Chosen from Abstracts Vaccination Against Mtb (Joint) Daniel A. Portnoy, University of California, Berkeley, USA Vaccines for Intracellular Pathogens Thomas G. Evans, Aeras Global TB Vaccine Foundation, USA Early Results of Vaccine Trials in Humans Stefan H.E. Kaufmann, Max Planck Institute for Infection Biology-Berlin, Germany Current Vaccines SATURDAY, MARCH 16 Life and Death in Mycobacteria Eric J. Rubin, Harvard School of Public Health, USA Protein Degradation and Pathogenesis Valerie Mizrahi, University of Cape Town, South Africa Vitamin B12 Metabolism in Mycobacteria Heran Darwin, New York University School of Medicine, USA Pedal to the Metal: Copper Resistance during Mtb Infections Graham F. Hatfull, University of Pittsburgh, USA Phages as Probes for Mycobacterial Physiology A Global View of Infection (Joint) Sebastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland Evolution of TB Speaker to be Announced Kanury V. S. Rao, International Centre for Genetic Engineering and Biotechnology, India Host Factors in Resistance SUNDAY, MARCH 17 The Bacterial Surface and its Interaction with the Host Mary Jackson, Colorado State University, USA Lipid and Carbohydrate Metabolism in Mycobacteria Keith M. Derbyshire, Wadsworth Center, New York State Department of Health, USA Mycobacterial Protein Secretion Michael Niederweis, University of Alabama at Birmingham, USA Mycobacterial Porins Short Talks Chosen from Abstracts Host Susceptibility to Disease (Joint) Hardy Kornfeld, University of Massachusetts Medical School, USA Diabetes and TB Erwin Schurr, Montreal General Hospital, McGill University, Canada Host Susceptibility to Mtb Jean-Laurent Casanova, Rockefeller University, USA Mendelian Susceptibilty to Mycobacteria MONDAY, MARCH 18: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 47 PRECISION GENOME ENGINEERING AND SYNTHETIC BIOLOGY: DESIGNING GENOMES AND PATHWAYS MARCH 1722, 2013 BEAVER RUN RESORT, BRECKENRIDGE, COLORADO, USA (venue information on page 27) DEADLINES: ABSTRACT & SCHOLARSHIP NOV 14, 2012 LATE-BREAKING ABSTRACT DEC 19, 2012 DISCOUNTED REGISTRATION JAN 17, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13C5 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C5. Scientic Organizers: Dana Carroll and Jef D. Boeke Sponsored by Sangamo BioSciences, Inc. SUNDAY, MARCH 17: ARRIVAL & REGISTRATION MONDAY, MARCH 18 Keynote Address Frances H. Arnold, California Institute of Technology, USA Evolutionary Engineering of Proteins and Pathways Pathway Engineering Douglas Densmore, Boston University, USA Clotho CAD for Synthetic Biology Stephen del Cardayre, LS9, Inc., USA Engineering E. coli Fatty Acid Metabolism for Sustainable Fuel and Chemical Production Ron Weiss, Massachusetts Institute of Technology, USA Synthetic Biology: From Parts to Modules to Therapeutic Systems Short Talk(s) Chosen from Abstracts Zinc-Finger Nucleases and TALENs Dana Carroll, University of Utah School of Medicine, USA Parameters Affecting ZFN- and TALEN-Mediated Gene Targeting Daniel Voytas, University of Minnesota, USA ZFNs and TALENs in Plants Thomas Lahaye, Ludwig-Maximilians-University Munich, Germany TALEs and TALENs: New Tools for Genome Editing and Transcriptome Modulation Toni Cathomen, Hannover Medical School, Germany Comparing ZFNs and TALENs TUESDAY, MARCH 19 Engineering Genomes Daniel Gibson, J. Craig Venter Institute, USA Synthetic Microbial Genomes Farren Isaacs, Yale University, USA Programming Genomes to Re-Engineer Lifes Functional Repertoire Sriram Kosuri, Wyss Institute, USA Reading and Writing DNA Jef D. Boeke, Johns Hopkins University School of Medicine, USA Synthetic Yeast Genome Short Talk(s) Chosen from Abstracts Genome Engineering in Humans and Other Animals Philip D. Gregory, Sangamo BioSciences, Inc., USA Clincal Trials with ZFNs Detlev Arendt, EMBL Heidelberg, Germany ZFN-Mediated Gene Targeting in Platynereis, a New Marine Molecular Model Organism Scott C. Fahrenkrug, University of Minnesota, USA Engineering of Food Animal Genomes Luigi M. Naldini, San Raffaele Telethon Institute, Italy Gene Targeting in Human Stem Cells by ZFNs WEDNESDAY, MARCH 20 Design in Synthetic Biology Tanja Kortemme, University of California, San Francisco, USA Computational Design of Proteins, Interactions and Networks Petra Schwille, Institute of Biophysics, Germany Design Features of Protein Gradient and Pattern Formation Jason Chin, MRC, Laboratory of Molecular Biology, UK Building on Orthogonal Translational Apparatus Yaakov (Kobi) Benenson, ETH Zrich, Switzerland Designing Anti-Cancer Circuits Based on miRNA Expression Patterns Short Talk(s) Chosen from Abstracts Targeting with Transposons, Integrases and Homing Endonucleases Nancy L. Craig, Johns Hopkins University School of Medicine, USA Transposon Target Selection Michele P. Calos, Stanford University School of Medicine, USA Integrase-Mediated Gene Addition to Create and Correct Induced Pluripotent Stem Cells Barry Stoddard, Fred Hutchinson Cancer Research Center, USA Engineered Homing Endonucleases for Gene Targeting via Single- and Double-Strand Breaks Short Talk Chosen from Abstracts THURSDAY, MARCH 21 Programming Organismal Behavior Virginia W. Cornish, Columbia University, USA Co-Opting Cells for Directed Evolution Jeff Hasty, University of California, San Diego, USA Engineered Gene Circuits: From Oscillators to Synchronized Clocks and Biopixels Christopher Voigt, University of California, San Francisco, USA Programming Devices and Networks June I. Medford, Colorado State University, USA Synthetic Signal Transduction and Design of New Traits Short Talk(s) Chosen from Abstracts Engineering Biofuel and Specialty Chemical Production Sang Yup Lee, Korea Advanced Institute of Science and Technology (KAIST), South Korea Redesigning Cellular Metabolism for Chemicals Production Edward M. Rubin, Lawrence Berkeley National Laboratory, USA Synthetic Metagenomics Zach Serber, Amyris, USA Engineering Biofuel and Specialty Chemical Platforms in Yeast Short Talk Chosen from Abstracts FRIDAY, MARCH 22: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 48 NEURONAL CONTROL OF APPETITE, METABOLISM AND WEIGHT MARCH 1722, 2013 FAIRMONT BANFF SPRINGS, BANFF, ALBERTA, CANADA (venue information on page 45) DEADLINES: ABSTRACT & SCHOLARSHIP NOV 14, 2012 LATE-BREAKING ABSTRACT DEC 19, 2012 DISCOUNTED REGISTRATION JAN 17, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13C6 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C6. Scientic Organizers: Tony K.T. Lam and Matthias H. Tschp SUNDAY, MARCH 17: ARRIVAL & REGISTRATION MONDAY, MARCH 18 Keynote Address Richard Palmiter, University of Washington, USA Hypothalamic Inlammation, ER Stress and Mitochondrial Function Gkhan S. Hotamisligil, Harvard University, USA ER Stress and Control of Metabolism Dongsheng Cai, Albert Einstein College of Medicine, USA Autophagy and Inlammation in Hypothalamic Neurons and Central Control of Metabolism Umut Ozcan, Childrens Hospital Boston, Harvard Medical School, USA Hypothalamic Inlammation, ER Stress and Metabolic Control Jens C. Brning, Institute for Genetics, University of Cologne, Germany Insulin Receptors in the Brain: Where Do They Matter? Short Talk(s) Chosen from Abstracts Workshop 1: Is the CNS Still a Relevant Pharmaceutical Target for Metabolic Disease? Addiction and Reward in the CNS Control of Metabolism Jeffrey M. Friedman, Rockefeller University, USA Neuroendocrine Control of Hedonic Feeding Behavior Tamas L. Horvath, Yale University School of Medicine, USA A Role for the Arcute Nucleus in Reward and Complex Behaviors Dana M. Small, Yale University School of Medicine, USA Imaging Addiction to Food in Humans Short Talk Chosen from Abstracts TUESDAY, MARCH 19 Nutrient Sensing and the Brain Daniele Piomelli, University of California, Irvine, USA Lipid Sensing and the Gut-Brain Axis Tony K.T. Lam, University of Toronto, Canada Nutrient Sensing in the Gut and the Brain Bradford B. Lowell, Beth Israel Deaconess Medical Center, USA Circuits Regulating Energy Balance Functional Dissection and Role of Synaptic Mechanisms Sabrina Diano, Yale University School of Medicine, USA Glucose Sensing and Hypothalamic Neuropeptide Processing Short Talk(s) Chosen from Abstracts Workshop 2: Challenges of the Publishing Process: How to Write a Scientiic Masterpiece Dissecting CNS Control of Metabolism I Kendra K. Bence, University of Pennsylvania, USA The Role of Phosphatase in the Neuronal Control of Energy Balance Christoph Buettner, Mount Sinai School of Medicine, USA CNS Control of Fat Metabolism Scott Sternson, HHMI/Janelia Farm Research Campus, USA A Novel Hypothalamic Memory Switch in the Regulation of Energy Homeostasis Short Talk Chosen from Abstracts WEDNESDAY, MARCH 20 Gut-Brain Interactions in the Control of Systemic Metabolism Daniel J. Drucker, Samuel Lunenfeld Research Institute, Canada The Biology of Incretins: Pleiotropic Metabolic Actions in Health and Disease Remy G. Burcelin, Institute of Molecular Medicine, France The Role of GLP-1 for the Gut-Brain Axis Richard D. DiMarchi, Indiana University, USA Novel Drug Treatments for Metabolic Disease: From Gut Hormones to Polypharmacy Rachel L. Batterham, University College London, UK Gut Peptide and Gastric Bypass Surgeries in Type 2 Diabetes Short Talk(s) Chosen from Abstracts Workshop 3: Novel Methodological Approaches to the Study of CNS Control of Metabolism Short Talks Chosen from Abstracts Dissecting CNS Control of Metabolism II Domenico Accili, Columbia University, USA FoxO1 Targets Regulating Energy Balance in the Central Nervous System Randy J. Seeley, University of Cincinnati, USA CNS PPAR- Markus Stoffel, Institute of Molecular Systems Biology, Switzerland CNS Foxa2 Short Talk Chosen from Abstracts THURSDAY, MARCH 21 Neurocircuitry and Systemic Control of Metabolism Lori M. Zeltser, Columbia University, USA Hypothalamic Development and Systemic Control of Metabolism Martin G. Myers, Jr., University of Michigan, USA Leptin Receptors in the Brain: Where Do They Matter? Michael A. Cowley, Monash University, Australia Leptin Modulation of DMH Circuits Controlling the Sympathetic Nervous System Roberto Coppari, University of Texas Southwestern Medical Center, USA Metabolic Actions of Hypothalamic SIRT1 Short Talk(s) Chosen from Abstracts Glia Cells and CNS Control of Metabolism Michael W. Schwartz, University of Washington, USA Hypothalamic Inlammation: "Primum movens of the Metabolic Syndrome? Matthias H. Tschp, University of Cincinnati Genome Research Institute Obesity Research Center, USA A Role for Hypothalamic Astrocytes in Obesity and Diabetes Licio A. Velloso, University of Campinas, Brazil A Role for Hypothalamic Microglia in Obesity and Diabetes Short Talk Chosen from Abstracts FRIDAY, MARCH 22: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 49 RNA SILENCING MARCH 1924, 2013 WHISTLER CONFERENCE CENTRE, WHISTLER, BRITISH COLUMBIA, CANADA (venue information on page 45) DEADLINES: ABSTRACT & SCHOLARSHIP NOV 15, 2012 LATE-BREAKING ABSTRACT DEC 20, 2012 DISCOUNTED REGISTRATION JAN 18, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13C7 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C7. Scientic Organizers: David C. Baulcombe and Irene Bozzoni TUESDAY, MARCH 19: ARRIVAL & REGISTRATION WEDNESDAY, MARCH 20 Keynote Address Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA Posttranscriptional RNA Silencing Pathways in Diverse Organisms Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany Mechanisms of miRNA-Mediated Gene Silencing A. Harel-Bellan, CEA, France siRNA and Splicing Craig P. Hunter, Harvard University, USA Mobile sRNA in C. elegans Olivier Voinnet, ETH Zrich, Switzerland RNA Silencing Pathways in Plants Short Talk Chosen from Abstracts piRNAs and RNA-Mediated Epigenetic Modiication I Phillip D. Zamore, University of Massachusetts Medical School, USA What Fruit Flies Teach Us About RNA Silencing Haifan Lin, Yale University, USA Cell Biology Suppression of Phenotypic Variation Ren F. Ketting, Hubrecht Institute, Netherlands piRNAs Zebraish Short Talk Chosen from Abstracts THURSDAY, MARCH 21 piRNAs and RNA-Mediated Epigenetic Modiication II Eric A. Miska, University of Cambridge, UK Small RNA and Transgenerational Effects in Worms David C. Baulcombe, University of Cambridge, UK Mobile RNA and Epigenetics in Plants Nicholas J. Proudfoot, University of Oxford, UK RNA and Epigenetic Modiication in Mammals Steven E. Jacobsen, HHMI/University of California, Los Angeles, USA Plants and Epigenetic Mechanisms Short Talk(s) Chosen from Abstracts Long ncRNA John L. Rinn, Harvard University, USA Linking RNA to Human Health and Disease Gordon Simpson, University of Dundee, UK Long Noncoding RNA in Plants Speaker to be Announced Short Talk Chosen from Abstracts FRIDAY, MARCH 22 ncRNA in Development and Disease I Speaker to be Announced Pier Paolo Pandoli, Beth Israel Deaconess Medical Center/Harvard Medical School, USA ceRNA Hypothesis Irene Bozzoni, University La Sapienza, Rome, Italy Role of Noncoding RNAs in Muscle Differentiation and in Neuromuscular Disorders Xavier Estivill, Center for Genomic Regulation and University Pompeu Fabra, Spain Neurodegenerative Disease Short Talk(s) Chosen from Abstracts ncRNA in Development and Disease II Robert A. Weinberg
, Whitehead Institute for Biomedical Research, USA
miRNA and Metastasis and Therapeutic Approaches Speaker to be Announced Klaus Pantel, Universittsklinikum Hamburg-Eppendorf, Germany Circulating MicroRNAs as Biomarkers in Cancer Patients Short Talk Chosen from Abstracts SATURDAY, MARCH 23 ncRNA in Development and Disease III Valerio Orlando, Dulbecco Telethon Institute at IRCCS Santa Lucia, Italy Dicer and Transcription Mechanisms Lin He, University of California, Berkeley, USA miRNAs at the Crossroad between Cancer and Reprogramming Jrgen Kjems, University of Aarhus, Denmark miRNA Sponges in Human Diseases Reuven Agami, Netherlands Cancer Institute, Netherlands miRNA Regulation by RNA-Binding Proteins and Cancer Short Talk(s) Chosen from Abstracts RNA Silencing in Virus Disease Shou-Wei Ding, University of California, Riverside, USA Induction and Suppression of RNA Silencing during Virus Infection Bryan R. Cullen, Duke University Medical Center, USA Viruses and microRNAs John J. Rossi, Beckman Research Institute of the City of Hope, USA Small Noncoding RNA Therapies for HIV-1 Short Talk Chosen from Abstracts SUNDAY, MARCH 24: DEPARTURE
Invited, not yet accepted
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 50 EPIGENETIC MARKS AND CANCER DRUGS MARCH 2025, 2013 ELDORADO HOTEL & SPA, SANTA FE, NEW MEXICO, USA (venue information on page 45) DEADLINES: ABSTRACT & SCHOLARSHIP NOV 19, 2012 LATE-BREAKING ABSTRACT DEC 21, 2012 DISCOUNTED REGISTRATION JAN 22, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13C8 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C8. Scientic Organizer: Ali Shilatifard Sponsored by Celgene Corporation WEDNESDAY, MARCH 20: ARRIVAL & REGISTRATION THURSDAY, MARCH 21 Keynote Address Stuart L. Schreiber, Harvard University, USA Linking Genetic Features of Human Cancers and Histone-Modifying Enzymes for Future Cancer Therapies Chromosome, Chromatin and Transcription I Shelley L. Berger*, University of Pennsylvania, USA B. Franklin Pugh, Pennsylvania State University, USA Nucleosomal Positioning and the Regulation of Gene Expression Patrick Cramer, University of Munich (LMU), Germany Structural Insight into the Transcribing RNA Polymerase II Anne Brunet, Stanford University, USA Epigenetic Regulation of Aging Short Talk(s) Chosen from Abstracts Chromosome, Chromatin and Transcription II Ali Shilatifard*, Stowers Institute for Medical Research, USA C. David Allis, Rockefeller University, USA Beyond the Double Helix: Varying the Histone Code Richard A. Young, Whitehead Institute for Biomedical Research, USA Connecting Transcription, Chromatin and Cancer Bradley R. Cairns, University of Utah, USA Chromatin Architecture in Gene Expression and Epigenetics Shiv I. S. Grewal, NCI, National Institutes of Health, USA RNAi-Dependent Formation of Heterochromatin FRIDAY, MARCH 22 Polycomb and Trithorax in Gene Expression and Cancer B. Franklin Pugh*, Pennsylvania State University, USA Ali Shilatifard, Stowers Institute for Medical Research, USA Active Chromatin Marks and Human Cancer Danny F. Reinberg, HHMI/New York University, USA Repressive Chromatin Marks in Epigenetics and Cancer Jrg Mller, Max Planck Institute of Biochemistry, Germany Polycomb Family in Transcriptional Repression and Development Peter Verrijzer, Erasmus University Medical Center, Netherlands Polycomb Family of Transcriptional Regulators in Development Short Talk(s) Chosen from Abstracts Histone Marks in Development and Cancer Ramin Shiekhattar*, Wistar Institute, USA Thomas Jenuwein, Max Planck Institute of Immunobiology and Epigenetics, Germany Talk Title to be Determined Tony Kouzarides, University of Cambridge, UK Histone Acetylation, Brd4 and Human Leukemia Alexander (Sasha) Tarakhovsky, Rockefeller University, USA Ezh2, Histone Methylation and Prostate Cancer Shelley L. Berger, University of Pennsylvania, USA Chromatin, Aging and Cancer
SATURDAY, MARCH 23 DNA Methylation in Development and Cancer Yi Zhang, University of North Carolina at Chapel Hill, USA DNA Demethylation and Epigenetics Peter A. Jones, University of Southern California, USA DNA Methylation and Cancer Therapy Jean-Pierre Issa, Temple University School of Medicine, USA Epigenetic Therapy from Bedside to Bench Short Talks Chosen from Abstracts Enhancers and ncRNAs in Development and Cancer Ramin Shiekhattar, Wistar Institute, USA Long Noncoding RNAs, and Enhancer and Gene Expression Jeannie T. Lee, Massachusetts General Hospital, USA Long Noncoding RNAs in Development Robert Martienssen, Cold Spring Harbor Laboratory, USA Talk Title to be Determined Short Talk Chosen from Abstracts SUNDAY, MARCH 24 Myc, Transcriptional Regulation and Development Robert N. Eisenman*, Fred Hutchinson Cancer Research Center, USA Regulation of Cell Function through the Myc Network Michael D. Cole, Dartmouth Medical School, USA An Epigenetic Model for Myc-Mediated Repression Bruno Amati, Italian Institute of Technology, Italy Epigenome Regulation in Myc-Driven Tumors James E. Bradner, Dana-Farber Cancer Institute, USA BET Bromodomain Inhibitors Targeting c-Myc Short Talk(s) Chosen from Abstracts Transcription, Chromatin and Epigenetics in Cancer Therapy Robert N. Eisenman*, Fred Hutchinson Cancer Research Center, USA Laurie A. Boyer, Massachusetts Institute of Technology, USA Noncoding Elements and Cell Fate Robert Gould, Epizyme, Inc., USA Epigenetic Therapy I Patrick Trojer, Constellation Pharmaceuticals, USA Targeting Histone Lysine Methylation in Cancer Short Talk Chosen from Abstracts MONDAY, MARCH 25: DEPARTURE *Session Chair This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 51 MOLECULAR CLOCKWORKS AND THE REGULATION OF CARDIO-METABOLIC FUNCTION APRIL 37, 2013 SNOWBIRD RESORT, SNOWBIRD, UTAH, USA (venue information on page 27) DEADLINES: ABSTRACT & SCHOLARSHIP DEC 3, 2012 LATE-BREAKING ABSTRACT JAN 3, 2013 DISCOUNTED REGISTRATION JAN 28, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13C9 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13C9. Scientic Organizers: Garret A. FitzGerald and Joseph S. Takahashi WEDNESDAY, APRIL 3: ARRIVAL & REGISTRATION THURSDAY, APRIL 4 Keynote Address Eric Schadt Paciic BiosciencesNount Sinai School of Neuicine 0SA Systems Integration by the Molecular Clock Clockworks I Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical Center, USA The Molecular Clock John Hogenesch, University of Pennsylvania School of Medicine, USA Systems Biology of the Molecular Clock Michael M. Rosbash, Brandeis University, USA Regulation of Clock Function in Drosophila Speaker to be Announced Clockworks II Ueli Schibler, University of Geneva, Switzerland Signaling to Peripheral Clocks Felix Naef, EPFL, Switzerland Genome-Wide Regulation of the Mammalian Metabolic Clock Martha Merrow, University of Groningen, Netherlands A Molecular Clock in Yeast FRIDAY, APRIL 5 Cardio-Metabolic I Speakers to be Announced Carla B. Green, University of Texas Southwestern Medical Center, USA Circadian Post-Transcriptional Regulation of Metabolic Pathways Clockworks III Erin K. OShea, Harvard University, USA Timekeeping with a Three-Protein Circadian Clock Akhilesh Basi Reddy, University of Cambridge, UK Clockworks Outside the Nucleus Steve A. Kay, University of California, San Diego, USA Drug-Dependent Regulation of Clock Function SATURDAY, APRIL 6 Cardio-Metabolic II R. Daniel Rudic, Georgia Health Sciences University, USA The Vascular Biology of the Molecular Clock Speakers to be Announced Frank A.J.L. Scheer, Harvard Medical School, USA Endogenous Biological Rhythms of Cardiovascular Function in Humans Cardio-Metabolic III Joseph T. Bass, Northwestern University, USA Metabolic Consequences of Clock Dysfunction Amita Sehgal, University of Pennsylvania, USA Central and Metabolic Impacts of Clock Function in Drosophila Garret A. FitzGerald, University of Pennsylvania, USA Cardiometabolic Implications of Peripheral Clocks SUNDAY, APRIL 7: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 52 ALPBACH CONGRESS CENTRUM ALPBACH, AUSTRIA FAIRMONT CHATEAU WHISTLER WHISTLER, BRITISH COLUMBIA, CANADA Local elevation: 3280 (1000 m) Local airports/distances to venue: Innsbruck Kranebitten (INN)/ 37 mi (60 km); Munich International (MUC)/105 mi (169 km) Local elevation: 2200 (671 m) Local airport/distance to venue: Vancouver International (YVR)/ 70 mi (115 km) BOSTON PARK PLAZA & TOWERS BOSTON, MASSACHUSETTS, USA Local elevation: 20 (6 m) Local airport/distance to venue: Logan International (BOS)/3 mi (5 km) OURO PRETO, MINAS GERAIS, BRAZIL VENUE TO BE DETERMINED Local elevation: 3871 (1180 m) Local airport/distance to venue: Belo Horizonte/Pampulha Carlos Drummond de Andrade (PLU)/71 mi (114 km) CLARION HOTEL SIGN STOCKHOLM, SWEDEN HYATT REGENCY MONTEREY MONTEREY, CALIFORNIA, USA Local elevation: 35 (11 m) Local airport/distance to venue: Stockholm Arlanda (ARN)/26 mi (41 km) Local elevation: 40 (12 m) Local airports/distances to venue: Monterey Peninsula (MRY)/2 mi (3 km); San Jose International (SJC)/72 mi (116 km) 53 IMMUNE ACTIVATION IN HIV INFECTION: BASIC MECHANISMS AND CLINICAL IMPLICATIONS APRIL 38, 2013 BEAVER RUN RESORT, BRECKENRIDGE, COLORADO, USA (venue information on page 27) DEADLINES: GLOBAL HEALTH TRAVEL AWARD NOV 6, 2012 ABSTRACT & SCHOLARSHIP DEC 3, 2012 LATE-BREAKING ABSTRACT JAN 3, 2013 DISCOUNTED REGISTRATION JAN 29, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13D2 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13D2. Scientic Organizers: Irini Sereti, Michaela Mller-Trutwin, Damian F.J. Purcell and Mauro Schechter Supported by the Ofce of AIDS Research, NIH; Sponsored by Sangamo BioSciences, Inc. Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation WEDNESDAY, APRIL 3: ARRIVAL & REGISTRATION Keynote Session Mary Carrington, Frederick National Laboratory for Cancer Research, USA The Inluence of Immunogenetic Variation on HIV Disease Michael M. Lederman, Case Western Reserve University, USA Immune Activation in HIV: Its Not Just the Virus, or Is It? THURSDAY, APRIL 4 Molecular and Cellular Biology of Immune Activation Charles R. Mackay, Monash University, Australia Diet and Gut Microbiota in the Regulation of Immunity and Gut Epithelial Permeability Susan Moir, NIAID, National Institutes of Health, USA B Cells in HIV Pathogenesis George Kassiotis, National Institute for Medical Research, UK Mechanisms of Lymphocyte Activation and T Cell-Mediated Pathology in Mice Infected by Retroviruses Frank Kirchhoff, University of Ulm, Germany Possible Role of Viral Properties in HIV-Induced Immune Activation Short Talk(s) Chosen from Abstracts Workshop 1: Therapeutic Targets of IA Short Talks Chosen from Abstracts HIV Transmission and Acute Infection Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA Imaging of Viral Dissemination in Cervical Mucus and Role of Ab Gabriella Scarlatti San Raffaele Scientiic Institute Italy Early Events of Transmission at the Intestinal Mucosal and Role of Dendritic Cells Michaela Mller-Trutwin, Institut Pasteur, France Innate Immune Responses in the Acute Phase of Non-Pathogenic SIVagm Infection Short Talk Chosen from Abstracts FRIDAY, APRIL 5 Viral Reservoirs and Immune Dysfunction Michael H. Malim, Kings College London School of Medicine, UK HIV and Innate Anti-Viral Factors Monsef Benkirane, Institut de Genetique Humaine, France Regulation of Cellular Factors Involved in HIV Virus Gene Expression Damian F.J. Purcell, University of Melbourne, Australia Mechanisms Taking Virus from Latency to T-Cell Activation Una ODoherty, University of Pennsylvania Medical Center, USA Important Differences between HIV Infection of Resting versus Activated T Cells Short Talk(s) Chosen from Abstracts Mucosal Immunity and HIV Mirko Paiardini, Emory University, YNPRC, USA Homeostasis of CD4 + T Cell Subsets in SIV Infection Jacob D. Estes, SAIC-Frederick, Inc., NCI-Frederick, USA GI Damage and Immune Activation in SIV FRIDAY, APRIL 5 (CONTINUED) Frederic D. Bushman, University of Pennsylvania School of Medicine, USA Deep Sequence of the Microbiome in HIV Short Talk Chosen from Abstracts SATURDAY, APRIL 6 Immune Activation and Co-Infections Nina Bhardwaj, New York University School of Medicine, USA Role of Dendritic Cells and Type I Interferons in HIV Pathogenesis and Immune Activation Michael L. Dustin, New York University School of Medicine, USA Imaging of Immune Synapses, Kinapses vs. Synapses, and Role in Inlammation Martyn French, University of Western Australia, Australia Immune Reconstitution Inlammatory Syndrome in HIV Infection Richard A. Koup, NIAID, National Institutes of Health, USA Role of Co-Pathogens in HIV Immune Dysfunction Short Talk(s) Chosen from Abstracts Workshop 2: HIV and Aging Short Talks Chosen from Abstracts Viral and Host Genes and Genomics Nabila Seddiki, Vaccine Research Institute and Universit Paris-Est Crteil (UPEC), France Role of Treg in HIV Pathogenesis Javier Martinez-Picado, ICREA and irsiCaixa Foundation, Spain HIV Persistence and Immune Activation Philip Tarr, University of Basel, Switzerland Genetic Associations of Non-Infectious Complications of HIV Short Talk Chosen from Abstracts SUNDAY, APRIL 7 Viral and Cellular Aspects of Immune Activation and Aging under Antiretroviral Therapy Alan J. Korman, Bristol-Myers Squibb, USA Immunostimulatory Monoclonal Ab to Reverse Immunosuppression Irini Sereti, NIAID, National Institutes of Health, USA Biomarkers in HIV Infection Ivona Pandrea, University of Pittsburgh, USA Lessons from Non-Human Primate Models Speaker to be Announced Short Talk(s) Chosen from Abstracts Future Directions in Immune Interventions Sharon R. Lewin, Alfred Hospital and Monash University, Australia Bench to Bedside: Where Do We Go from Here? Mauro Schechter, Universidade Federal do Rio de Janeiro, Brazil Preventive Efforts, New Directions Beyond Vaccines Steven G. Deeks, University of California, San Francisco, USA HIV and Aging: Novel Therapeutic Approaches MONDAY, APRIL 8: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 54 NUCLEAR RECEPTORS AND FRIENDS: ROLES IN ENERGY HOMEOSTASIS AND METABOLIC DYSFUNCTION APRIL 38, 2013 ALPBACH CONGRESS CENTRUM, ALPBACH, AUSTRIA (venue information on page 53) DEADLINES: ABSTRACT & SCHOLARSHIP DEC 4, 2012 LATE-BREAKING ABSTRACT JAN 4, 2013 DISCOUNTED REGISTRATION JAN 31, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13D3 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13D3. Scientic Organizers: Antonio J. Vidal-Puig, Antonio Moschetta and Anastasia Kralli WEDNESDAY, APRIL 3: ARRIVAL & REGISTRATION THURSDAY, APRIL 4 Keynote Address Helen H. Hobbs, University of Texas Southwestern Medical Center, USA Role of ABC Transporters in Lipid Transport Nuclear Receptors and Metabolism: Liver and Gut Pathways Antonio Moschetta, Consorzio Mario Negri Sud, Italy Regulation of Enterocyte Aging via PGC1 David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA Nuclear Receptor/FGF Endocrine Signaling and Metabolism David D. Moore, Baylor College of Medicine, USA LRH1, the Gut and the Liver Michela Plateroti, Universit Claude Bernard Lyon 1, France Thyroid Receptor and Intestinal Stemness Nuclear Receptors and Control of Food Intake Miguel Lpez, Universidad de Santiago de Compostela, Spain Oestrogen Receptors and Energy Balance Joel K. Elmquist, University of Texas Southwestern Medical Center, USA SF1 in VMN and Energy Balance Tony K.T. Lam, University of Toronto, Canada Nutrient and Hypothalamus Sensing Short Talk Chosen from Abstracts FRIDAY, APRIL 5 Nuclear Receptors and Energy Expenditure Pathways Anastasia Kralli, The Scripps Research Institute, USA The Role of The PGC-1/ERR Network in Mitochondrial Function and BAT Physiology Antonio J. Vidal-Puig, University of Cambridge, UK Brown Fat Activity Sensitizers Krishna Chatterjee, University of Cambridge, UK Nuclear Receptors and Metabolic Dysfunction: Insights from Human Genetics Beatrice Desvergne, University of Lausanne, Switzerland Too Much or Too Little Fat: Same Metabolic Consequences, Same Mechanisms? Short Talk(s) Chosen from Abstracts Workshop and Round-Table Discussion: Targeting NRs for the Treatment of Metabolic Disease Short Talks Chosen from Abstracts Adipogenesis and Energy Storage Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA Systems Approaches to Adipogenesis Juro Sakai, University of Tokyo, Japan Epigenomic Regulation of Inlammation, Energy Metabolism and Adipogenesis Lluis Fajas, INSERM, France Cell Cycle and Energy Homeostasis Short Talk Chosen from Abstracts SATURDAY, APRIL 6 Lipid Metabolic Sensors Peter Tontonoz, University of California, Los Angeles, USA Idolizing the LDL Receptor Karen Reue, University of California, Los Angeles, USA Lipin Proteins and Cellular Lipid Homeostasis David Shapiro, Intercept Pharmaceuticals Inc., USA FXR Agonism From Theory to Practice Carl S. Thummel, University of Utah School of Medicine, USA Lipid Metabolism in Flies Short Talk(s) Chosen from Abstracts Workshop 2 Short Talks Chosen from Abstracts Immune System and Metabolism Mercedes Ricote, Centro Nacional de Investigaciones Cardiovasculares, Spain Emerging Roles of RXRs in Macrophage Biology Ajay Chawla, University of California, San Francisco, USA Innate Immunity and Metabolism Inez Rogatsky, Weill Medical College of Cornell University, USA A Transcriptional Coregulator GRIP1 at the Intersection of Pro- and Anti-Inlammatory Pathways Short Talk Chosen from Abstracts SUNDAY, APRIL 7 Skeletal Muscle, Exercise and Diet Daniel P. Kelly, Sanford-Burnham Medical Research Institute, USA Nuclear Receptor miRNA Regulatory Networks Juleen R. Zierath, Karolinska Institutet, Sweden Epigenetic Regulation in Response to Exercise Ronald M. Evans, The Salk Institute, USA PPARs, ERRs, Muscle Vincent Gigure, McGill University, Canada Estrogen-Related Receptors and Control of Energy Metabolic Pathways Short Talk(s) Chosen from Abstracts Circadian Clock and Metabolism Katja A. Lamia, The Scripps Research Institute, USA Cryptochromes Are NR Co-Repressors Thomas P. Burris, The Scripps Research Institute, USA ROR and REV-ERB Regulation of Immune Function and Metabolism Paolo Sassone-Corsi, University of California, Irvine, USA Metabolism Control of the Circadian Clock Short Talk Chosen from Abstracts MONDAY, APRIL 8: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 55 IMMUNOPATHOLOGY OF TYPE 1 DIABETES APRIL 49, 2013 FAIRMONT CHATEAU WHISTLER, WHISTLER, BRITISH COLUMBIA, CANADA (venue information on page 53) Scientic Organizers: Kevan C. Herold, Dario A.A. Vignali, Jeffrey A. Bluestone and Anne Cooke Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13Z1. JOINT WITH... THURSDAY, APRIL 4: ARRIVAL & REGISTRATION Keynote Session (Joint) Luke A. J. ONeill, Trinity College Dublin, Ireland Innate Immunity, Inlammation and Autoimmunity Diane J. Mathis, Harvard Medical School, USA Control of Autoimmune Diabetes FRIDAY, APRIL 5 Modulation of Immunity toward Autoimmune Therapy: From Mouse to Man (Joint) Dario A. A. Vignali, St. Jude Childrens Research Hospital, USA Molecular Control of Regulatory Networks in Autoimmunity Jeffrey A. Bluestone, University of California, San Francisco, USA Treg Plasticity and Function: Mechanisms and Therapeutic Implications Richard A. Flavell, Yale University School of Medicine, USA Humanized Mouse Models in the Study of Autoimmune Diseases Stephen D. Miller, Northwestern University Medical School, USA Induction of Immune Tolerance in the Treatment of Autoimmunity Maria Grazia Roncarolo San Raffaele Scientiic Institute Italy Disregulation of Immune Response in Genetic and Acquired Autoimmune Diseases Short Talk Chosen from Abstracts Immune Effector/Autoantigens in T1DM Gerald T. Nepom, Benaroya Research Institute, USA The T Cell Repertoire in Human Autoimmune Diabetes Teresa P. DiLorenzo, Albert Einstein College of Medicine, USA Antigen-Speciic T Cells in NOD Diabetes Mark Peakman, Kings College London, UK Pathogenic T Cells in Human T1D Short Talk Chosen from Abstracts SATURDAY, APRIL 6 Regulatory and Developmental Control of T1DM Mark Anderson, University of California, San Francisco, USA Peripheral Tolerance-AIRE: Whats New, Whats Next? Steven F. Ziegler, Benaroya Research Institute and University of Washington School of Medicine, USA Transcriptional Control of Tregs Pere Santamaria, University of Calgary, Canada Maturation and Modulation of CD8+ T Effector Cells Jane H. Buckner, Benaroya Research Institute at Virginia Mason, USA T Cell Deregulation in Human T1DM David A. Haler, Yale School of Medicine, USA Human Autoimmunity, a Common Genetic Disease(s Short Talk Chosen from Abstracts Workshop 1: Basic Research Advances Short Talks Chosen from Abstracts Workshop 2: Translational/Clinical Research Advances Short Talks Chosen from Abstracts SUNDAY, APRIL 7 The Microlora in the Regulation of Immunity and Autoimmunity (Joint) Karen E. Nelson, J. Craig Venter Institute, USA The Makeup of the Human Microbiome Alexander Chervonsky, University of Chicago, USA Microbial Inluence on T1D Fiona M. Powrie, University of Oxford NDM, UK Regulation of Colitis by the Gut Microbiome Mark A. Atkinson, University of Florida, USA The Gut Microbiome in Diabetes Lloyd H. Kasper, Dartmouth Medical School, USA Gut, Bugs and the Brain: The Role of Commensal Bacteria in CNS Demyelination Short Talk Chosen from Abstracts Immune Modulation and Effects of Immune Modulators on T1DM Matthias G. von Herrath, La Jolla Institute for Allergy and Immunology, USA Autoreactive CD8 Cells How Do We Best Control Them to Treat T1D? Lucienne Chatenoud, INSERM U1013, Hpital Necker-Enfants Malades, France Anti-CD3 Therapy Bart O. Roep, Leiden University Medical Center, Netherlands Methods and Mechanisms of Immune Modulation in Humans Short Talk Chosen from Abstracts MONDAY, APRIL 8 Cellular and Environmental Networks in T1DM Li Wen, Yale University, USA Role of TLRs in Regulation of Autoimmunity and Cells in Type 1 Diabetes Anne Cooke, University of Cambridge, UK Th17 Cells in T1DM Agns C. Lehuen, Hpital Saint Vincent de Paul, France Viral Infections and NKT Cells in Type 1 Diabetes David V. Serreze, The Jackson Laboratory, USA To Be or Not to Be: Challenges in B-Lymphocyte-Directed Interventions for Type 1 Diabetes George S. Eisenbarth, University of Colorado Health Sciences Center, USA Autoantigen Presentation in Type 1 Diabetes: Opportunity for Antigen-Speciic Interventions? Short Talk Chosen from Abstracts The Future of T1DM Research and Clinical Translation Linda S. Wicker, University of Cambridge, UK IL-2 Therapy for Type 1 Diabetes Kevan C. Herold, Yale University, USA Combination Therapies for Type 1 Diabetes Megan K. Levings, University of British Columbia, Canada Regulatory T Cell Therapy in Autoimmunity and Transplantation Short Talk Chosen from Abstracts TUESDAY, APRIL 9: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 56 ADVANCES IN THE KNOWLEDGE AND TREATMENT OF AUTOIMMUNITY Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13Z2. DEADLINES FOR BOTH CONFERENCES: ABSTRACT & SCHOLARSHIP DEC 4, 2012 LATE-BREAKING ABSTRACT JAN 4, 2013 DISCOUNTED REGISTRATION FEB 4, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13Z1 or /13Z2 Scientic Organizers: Juan Rivera, Virginia Pascual and David M. Lee Sponsored by Biogen Idec and MedImmune Registering for one conference in a set of joint conferences enables participation in sessions of the other, pending space availability. THURSDAY, APRIL 4: ARRIVAL & REGISTRATION Keynote Session (Joint) Luke A. J. ONeill, Trinity College Dublin, Ireland Innate Immunity, Inlammation and Autoimmunity Diane J. Mathis, Harvard Medical School, USA Control of Autoimmune Diabetes FRIDAY, APRIL 5 Modulation of Immunity toward Autoimmune Therapy: From Mouse to Man (Joint) Dario A. A. Vignali, St. Jude Childrens Research Hospital, USA Molecular Control of Regulatory Networks in Autoimmunity Jeffrey A. Bluestone, University of California, San Francisco, USA Treg Plasticity and Function: Mechanisms and Therapeutic Implications Richard A. Flavell, Yale University School of Medicine, USA Humanized Mouse Models in the Study of Autoimmune Diseases Stephen D. Miller, Northwestern University Medical School, USA Induction of Immune Tolerance in the Treatment of Autoimmunity Maria Grazia Roncarolo San Raffaele Scientiic Institute Italy Disregulation of Immune Response in Genetic and Acquired Autoimmune Diseases Short Talk Chosen from Abstracts Mechanisms of Peripheral and Central Tolerance John W. Kappler, National Jewish Health, USA MHC Peptide Registers-MHC Complexity Beyond Peptide Kristin Tarbell*, NIDDK, National Institutes of Health, USA The Role of DCs for Antigen-Speciic Tolerance Induction in the Context of Autoimmune Diabetes Shannon J. Turley, Dana-Farber Cancer Institute, Harvard Medical School, USA Regulation of Dendritic Cell and T Cell Function by Nonhematopoietic Stroma Short Talk Chosen from Abstracts SATURDAY, APRIL 6 Innate Immunity and Autoimmune Disease Silvia Bolland*, NIAID, National Institutes of Health, USA TLR7 and Autoimmunity Virginia Pascual, Baylor Institute for Immunology Research, USA pDCs and IFN Signature in SLE Juan Rivera, NIAMS, National Institutes of Health, USA Basophils in the Ampliication of SLE Melissa A. Brown, Northwestern University, USA Mast Cells and Neutrophils in CNS Disease Short Talk(s) Chosen from Abstracts Challenges and Lessons from Immunotherapy Timothy W. Behrens*, Genentech, Inc., USA Biomarkers for Clinical Trials and the Clinic Where to Next? Thi-Sau Migone, Human Genome Sciences, USA Belimumab: What Are We Learning from the Treatment of Lupus? Robert P. Anderson, Walter and Eliza Hall Institute of Medical Research, Australia Celiac Disease Can We Transition from Peptides to Treatment? Short Talk Chosen from Abstracts SUNDAY, APRIL 7 The Microlora in the Regulation of Immunity and Autoimmunity (Joint) Karen E. Nelson, J. Craig Venter Institute, USA The Makeup of the Human Microbiome Alexander Chervonsky, University of Chicago, USA Microbial Inluence on T1D Fiona M. Powrie, University of Oxford NDM, UK Regulation of Colitis by the Gut Microbiome Mark A. Atkinson, University of Florida, USA The Gut Microbiome in Diabetes Lloyd H. Kasper, Dartmouth Medical School, USA Gut, Bugs and the Brain: The Role of Commensal Bacteria in CNS Demyelination Short Talk Chosen from Abstracts Workshop 1: Basic Mechanisms in Autoimmunity Short Talk(s) Chosen from Abstracts Workshop 2: Clinical and Translational Aspects of Autoimmunity Short Talk(s) Chosen from Abstracts Lymphocytes in Autoimmunity I B Cells Eric Meffre, Yale University School of Medicine, USA Autoreactive B Cells Who, What, Where? Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Berlin, Germany Plasmablasts vs. Plasma Cells Roles in Autoantibody Production Thomas F. Tedder, Duke University Medical Center, USA B Cell Regulation of Immune Responses Short Talk Chosen from Abstracts MONDAY, APRIL 8 Lymphocytes in Autoimmunity II T Cells Federica Sallusto, Institute for Research in Biomedicine, Switzerland T Cell Subsets in Human Disease Shigeo Koyasu, Keio University School of Medicine, Japan Natural Helper Cells in Th2-Type Innate Immunity Carola G. Vinuesa, Australian National University, Australia T Follicular Helper Cells during Immunity and Tolerance Vijay K. Kuchroo, Brigham and Womens Hospital, Harvard Medical School, USA Th17 Cells in Tissue Inlammation and Autoimmunity Short Talk(s) Chosen from Abstracts Systems Approaches to Autoimmunity Speaker to be Announced Edward K. Wakeland, University of Texas Southwestern Medical Center, USA Genomic Analysis of Systemic Autoimmunity Atul J. Butte, Stanford University, USA Personalized and Systems Medicine Short Talk Chosen from Abstracts TUESDAY, APRIL 9: DEPARTURE *Session Chair This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 57 CARDIAC REMODELING, SIGNALING, MATRIX AND HEART FUNCTION APRIL 712, 2013 SNOWBIRD RESORT, SNOWBIRD, UTAH, USA (venue information on page 27) DEADLINES: ABSTRACT & SCHOLARSHIP DEC 5, 2012 LATE-BREAKING ABSTRACT JAN 9, 2013 DISCOUNTED REGISTRATION FEB 6, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13D4 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13D4. Scientic Organizers: Anthony J. Muslin, Jil C. Tardiff and Steven R. Houser Sponsored by Bayer USA Foundation SUNDAY, APRIL 7: ARRIVAL & REGISTRATION MONDAY, APRIL 8 Keynote Address Bruce M. Spiegelman, Harvard Medical School, USA The Regulation of Physiologic Cardiac Growth by C/EBP Transcription Factors Regenerating Injured Myocardium Deepak Srivastava, Gladstone Institute of Cardiovascular Disease, USA Genetic Reprogramming of Fibroblasts in the Myocardium Eric N. Olson, University of Texas Southwestern Medical Center, USA In situ Generation of Cardiac Myocytes William T. Pu, Childrens Hospital, Harvard Medical School, USA Transcriptional Pathways in Cardiac Regeneration Issei Komuro, Osaka University Graduate School, Japan Cardiac Angiogenesis and Myogenesis Bioengineering and Tissue Repair Joseph C. Wu, Stanford University, USA Imaging Cardiac Stem Cell Therapy Richard T. Lee, Harvard University, USA Bioengineering to Promote Cardiac Regeneration Josef M. Penninger, Institute of Molecular Biotechnology GmbH, Austria Apelin and ACE2 Regulate Cardiac Fibrosis and Function TUESDAY, APRIL 9 Genetic Causes of Cardiomyopathy Elizabeth M. McNally, University of Chicago, USA Modiier Genes for Heart and Muscle Disease Christine E. Seidman, Harvard Medical School, USA Cardiac Fibrosis in Hypertrophic Cardiomyopathy Howard A. Rockman, Duke University Medical Center, USA The Use of Drosophila Genetic Screens to Investigate Cardiomyopathy Xuejun Wang, University of South Dakota, USA Protein Quality Control in Cardiac Proteinopathies Workshop: Developing Novel Therapeutic Agents for Heart Failure Short Talks Chosen from Abstracts MicroRNA Regulation of Cardiac Function Gerald W. Dorn, II, Washington University School of Medicine, USA MicroRNA Regulation of Cardiac Hypertrophy and Failure Edward E. Morrisey, University of Pennsylvania, USA MicroRNA-Mediated Programming and Reprogramming of Somatic Cells Walter J. Koch, Temple University School of Medicine, USA Regulation of Cardiac Hypertrophy by GRKs WEDNESDAY, APRIL 10 Calcium Signaling, Protein Kinases and Cardiac Dysfunction Joan Heller Brown, University of California, San Diego, USA Localized Calcium Signaling and CamKII Steven R. Houser, Temple University School of Medicine, USA Calcium Inlux Pathways that Regulate Hypertrophy Jeffery D. Molkentin, Cincinnati Childrens Hospital Medical Center, USA Calcium Signaling Pathways that Regulate Cardiac Growth Mark E. Anderson, University of Iowa, USA Calcium Signaling in Cardiac Arrhythmias Cardiac Autophagy and Proteolysis Norbert Perrimon, Harvard Medical School, USA FoxO and 4EBP Regulation of Drosophila Muscle Physiology Roberta Gottlieb, San Diego State University, USA Mitophagy and Cardioprotection Asa B. Gustafsson, University of California, San Diego, USA Mitochondrial Autophagy in Ischemic Myocardium THURSDAY, APRIL 11 Cardiac Mechanics Fady Malik, Cytokinetics Inc., USA Cardiac Myosin Activators for the Treatment of Heart Failure Jil C. Tardiff, University of Arizona, USA Thin Filament Function in Cardiac Physiology Henk Granzier, University of Arizona, USA The Role of Titin in Cardiac Function and Disease Samantha Harris, University of California, Davis, USA Cardiac Myosin Binding Protein-C Cardiac Extracellular Matrix in Disease Ronglih Liao, Brigham and Womens Hospital, USA New Insights into Amyloid Cardiomyopathy Thomas Eschenhagen, University Medical Center Hamburg Eppendorf, Germany Cardiac Tissue Engineering Anthony J. Muslin, Novartis Institutes for BioMedical Research, Inc., USA Developing Drugs to Reduce Cardiac Fibrosis and Improve Function FRIDAY, APRIL 12: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 58 PLANT IMMUNITY: PATHWAYS AND TRANSLATION APRIL 712, 2013 BIG SKY RESORT, BIG SKY, MONTANA, USA (venue information on page 21) DEADLINES: ABSTRACT & SCHOLARSHIP DEC 6, 2012 LATE-BREAKING ABSTRACT JAN 10, 2013 DISCOUNTED REGISTRATION FEB 7, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13D5 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13D5. Scientic Organizers: Sophien Kamoun and Ken Shirasu SUNDAY, APRIL 7: ARRIVAL & REGISTRATION MONDAY, APRIL 8 Keynote Address Paul M. Schulze-Lefert, Max Planck Institute for Plant Breeding Research, Germany Structure and Functions of the Plant Bacterial Microbiome Surface Receptor-Mediated Immunity Recognition Georg Felix, University of Tbingen, Germany Recognition of PAMPs and Other Danger Signals by Surface Receptors Pamela C. Ronald, University of California, Davis, USA Recognition of Ax21 by Rice Receptor Xa21 Naoto Shibuya, Meiji University, Japan Chitin Perception in Rice and Arabidopsis Short Talk(s) Chosen from Abstracts Workshop 1: Systems Approaches to Plant Immunity Fumiaki Katagiri*, University of Minnesota, USA Short Talks Chosen from Abstracts Surface Receptor-Mediated Immunity Signaling Cyril Zipfel, Sainsbury Laboratory, UK PAMP-Triggered Immunity Signaling Birgit Kemmerling, University of Tbingen, Germany PAMP-Triggered Immunity Signaling Hirofumi Yoshioka, Nagoya University, Japan Roles of MAPK and CDPK in PAMP-Triggered Immunity TUESDAY, APRIL 9 Intracellular Immunity Recognition Peter N. Dodds, CSIRO Plant Industry, Australia Recognition of Rust Effectors by NBS-LRR Proteins Gitta L. Coaker, University of California, Davis, USA Activation of Effector Triggered Immunity Jeffery L. Dangl, University of North Carolina at Chapel Hill, USA The Plant Immune System: Response to Infection and Maintenance of Homeostasis Speaker to be Announced Short Talk(s) Chosen from Abstracts Intracellular Immunity Signaling Peter Moffett, University of Sherbrooke, Canada NB-LRR-Mediated Anti-Viral Responses Xin Li, University of British Columbia, Canada NBS-LRR Signaling Jonathan D.G. Jones, Sainsbury Laboratory, UK Disease Resistance Mediated by NB-LRR Pairs WEDNESDAY, APRIL 10 Suppression of Immunity Jianmin Zhou, National Institute of Biological Sciences, China Suppression of PAMP-Triggered Immunity by Bacterial Effectors Bart P.J. Thomma, Wageningen University, Netherlands Suppression of Chitin Response Sophien Kamoun, Sainsbury Laboratory, UK Suppression of Immunity by Oomycete Effectors Speaker to be Announced Short Talk(s) Chosen from Abstracts Workshop 2: Emerging Pathogens and Pests Short Talks Chosen from Abstracts Evolutionary Plant-Microbe Interactions Detlef Weigel, Max Planck Institute for Developmental Biology, Germany The Plant Immune System at the Nexus of Trade-Offs Affecting Fitness and Gene Flow Wenbo Ma, University of California, Riverside, USA Effectors of Plant Pathogens Short Talks Chosen from Abstracts THURSDAY, APRIL 11 Translating Plant Immunity Brian J. Staskawicz, University of California, Berkeley, USA Resistance to Xanthomonads Eric R. Ward, Two Blades Foundation, USA Resistance to Rusts Ken Shirasu, RIKEN, Japan Striga-Host Interactions Vivianne Vleeshouwers, Wageningen University, Netherlands Exploiting Effectors in Resistance Breeding Short Talk(s) Chosen from Abstracts Emerging Topics in Plant Immunity Thomas J. Wolpert, Oregon State University, USA Victoria Blight: When Defense Becomes Defenseless Renier A.L. Van der Hoorn, Max Planck Institute for Plant Breeding Research, Germany Apoplastic Enzymes and Defense Silke Robatzek, Sainsbury Laboratory, UK Cell Biology of Plant Immune Response FRIDAY, APRIL 12: DEPARTURE *Session Chair This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 59 POSITIVE STRAND RNA VIRUSES APRIL 28MAY 3, 2013 BOSTON PARK PLAZA & TOWERS, BOSTON, MASSACHUSETTS, USA (venue information on page 53) DEADLINES: ABSTRACT & SCHOLARSHIP DEC 20, 2012 LATE-BREAKING ABSTRACT JAN 31, 2013 DISCOUNTED REGISTRATION FEB 28, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13D7 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13D7. SUNDAY, APRIL 28: ARRIVAL & REGISTRATION MONDAY, APRIL 29 Keynote Address Herbert (Skip) W. Virgin IV, Washington University School of Medicine, USA The Virome and Disease Susceptibility: More Than One Way To Be a Pathogen (or a friend Innate Immunity: Sensing and Defending Takashi Fujita, Institute for Virus Research, Kyoto University, Japan Sensing Viral RNA and Antiviral Responses John Schoggins, Rockefeller University, USA Antiviral Type I Interferon Effectors Targeting RNA Viruses Margo A. Brinton, Georgia State University, USA Flavivirus RNA Structure Short Talk(s) Chosen from Abstracts Evolution of Viruses in the Environment Marco Vignuzzi, Pasteur Institut, France Virus Micro-Evolution and Subpopulations within the Infected Host Marilyn Roossinck, Pennsylvania State University, USA The Big Unknown: Plant Virus Biodiversity and Ecosystem Impacts Raul Andino, University of California, San Francisco, USA RNA Virus Evolution Short Talk Chosen from Abstracts TUESDAY, APRIL 30 Systems Biology of +RNA Virus-Host Interaction Carolyn B. Coyne, University of Pittsburgh, USA siRNA Screens for Enteroviruses Peter D. Nagy, University of Kentucky, USA Reprogramming Cellular Pathways by Tombusviruses to Facilitate Replication Ralf Bartenschlager, University of Heidelberg, Germany Host Factors in Flavivirus Replication Lucas Pelkmans, University of Zurich, Switzerland Systems Biology of Virus-Host Interaction Short Talk(s) Chosen from Abstracts Workshop 1 Short Talks Chosen from Abstracts Entry and Assembly Sara R. Cherry, University of Pennsylvania School of Medicine, USA Alphavirus Entry William M. Gelbart, University of California, Los Angeles, USA Assembly of Bromo and Alpha Viruses and their Hybrids Glenn C. Randall, University of Chicago, USA Mechanisms of Hepatitis C Virus Assembly and Egress Short Talk Chosen from Abstracts WEDNESDAY, MAY 1 Adaptive Immunity and Vaccines Kim Y. Green, NIAID, National Institutes of Health, USA Norovirus Pathogenesis and Vaccines Robert Thimme, University Medical Center Freiburg, Germany Failure of Adaptive Immunity to Clear HCV Infection Christian W. Mandl, Novartis Vaccines and Diagnostics, Inc, USA Alphavirus-Vectored Vaccines Diane E. Grifin, Johns Hopkins Bloomberg School of Public Health, USA Alphavirus Encephalitis: Mechanisms of Virus Clearance Short Talk(s) Chosen from Abstracts RNA Structure and Function Andrea Gamarnik, Fundacin Instituto Leloir, Argentina Dynamics, Plasticity and Functions of the Dengue Virus Genome Peter Sarnow, Stanford University School of Medicine, USA MicroRNAs and their Role in Regulating HCV Replication Ian Brierley, University of Cambridge, UK Translational Gymnastics of RNA Viruses Short Talk(s) Chosen from Abstracts THURSDAY, MAY 2 Replication Enzymes and their Inhibition Bruno Canard, AFMB ESIL Case 925, France The Interplay of RNA Synthesis, Fidelity and RNA Capping in Coronaviruses Eric J. Snijder, Leiden University Medical Center, Netherlands The Versatility of Arterivirus NSP2 Nuria Verdaguer, Institut de Biologia Molecular de Barcelona (CSIC), Spain FMDV RdRp: Structure and Fidelity John O. Link, Gilead Sciences, Inc, USA Inhibitors of Hepatitis C Virus Replication: Viral and Host Cell Targets Short Talk(s) Chosen from Abstracts Workshop 2 Short Talks Chosen from Abstracts Pathogenesis (Includes UPR, Stress Responses, Autophagy) Beth Levine, University of Texas Southwestern Medical Center, USA Selective Autophagy in Antiviral Immunity Stanley M. Lemon, University of North Carolina at Chapel Hill, USA Pathogenesis of HCV and HAV Jari Valkonen, University of Helsinki, Finland Plant RNA Virus-Host Interactions Short Talk Chosen from Abstracts FRIDAY, MAY 3: DEPARTURE This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 60 Scientic Organizers: Eric J. Snijder and Ralf Bartenschlager THE INNATE IMMUNE RESPONSE IN THE PATHOGENESIS OF INFECTIOUS DISEASE MAY 1015, 2013 OURO PRETO, MINAS GERAIS, BRAZIL (venue information on page 53) DEADLINES: GLOBAL HEALTH TRAVEL AWARD DEC 11, 2012 ABSTRACT & SCHOLARSHIP JAN 7, 2013 LATE-BREAKING ABSTRACT FEB 4, 2013 DISCOUNTED REGISTRATION MAR 5, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster session, plenary session or workshop. WWW.KEYSTONESYMPOSIA.ORG/13E1 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13E1. FRIDAY, MAY 10: ARRIVAL & REGISTRATION Keynote Session Rodrigo Corra-Oliveira*, FIOCRUZ Minas, Brazil Keystone Brazil and the Challenges of Global Tropical Diseases Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France Innate Immune Pathways in Drosophila Jean-Laurent Casanova, Rockefeller University, USA Toward a Genetic Theory of Infectious Diseases SATURDAY, MAY 11 Innate Immune Recognition Caetano Reis e Sousa, Cancer Research UK London Research Institute, UK Myeloid C-Type Lectin Receptors in Pathogen Recognition and Host Defense Vishva M. Dixit, Genentech, Inc., USA Inlammasome Activation Kate A. Fitzgerald, University of Massachusetts Medical School, USA Immune Surveillance from the Cytosol Julie Magarian Blander, Mount Sinai School of Medicine, USA Detecting and Responding to Microbial Viability Short Talk(s) Chosen from Abstracts Workshop 1: Innate Recognition and Microbial Pathogenesis Short Talks Chosen from Abstracts Innate Immunity in Vectors Elena A. Levashina*, Max Planck Institute for Infection Biology, Germany Mechanisms of Innate Resistance to Malaria Parasites in the Mosquito George Dimopoulos, Johns Hopkins University, USA Innate and Microbiota-Mediated Control of Dengue Virus in Mosquitoes David L. Sacks, NIAID, National Institutes of Health, USA Inluence of Vector Transmission on the Innate Immune Response to Leishmania major Short Talk Chosen from Abstracts SUNDAY, MAY 12 Innate Lymphoid Cells (ILC) and Mucosal Immunity Fiona M. Powrie*, University of Oxford NDM, UK Innate Regulation of Intestinal Mucosal Inlammation David Artis, University of Pennsylvania, School of Medicine, USA ILC in Regulation of Mucosal Immune Responses Dan R. Littman, New York University School of Medicine, USA Immune Homeostasis and Host Protection by Commensal Bacteria Marco Colonna, Washington University School of Medicine, USA NK Cells in Innate Immune Responses in Mucosal Sites Short Talk(s) Chosen from Abstracts Workshop 2: Cytokine, Inlammation and Pathogenesis Short Talks Chosen from Abstracts Effector Mechanisms Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany DNA Nets, a Potent Anti-Microbial Effector Function of Neutrophils Speaker to be Announced Jonathan Howard, University of Cologne, Germany IFN--Inducible GTPases in Control of Intracellular Parasites Short Talk Chosen from Abstracts MONDAY, MAY 13 Innate Cytokines Inluencing Adaptive Immunity and Inlammation Richard M. Locksley*, University of California, San Francisco, USA Innate Determinants of Th2 Responses Alan Sher, NIAID, National Institutes of Health, USA Innate Regulation of Th1 Responses Kingston H. G. Mills, Trinity College Dublin, Ireland Innate Determinants of Th17 Responses Edgar M. Carvalho, Universidade Federal da Bahia, Brazil Innate Determinants of T Lymphocyte Responses in Human Leishmaniasis Short Talk(s) Chosen from Abstracts Workshop 3: Cell Death and Pathogenesis Short Talks Chosen from Abstracts Innate Signals in Disease Pathogenesis Speaker to be Announced Douglas Golenbock, University of Massachusetts Medical School, USA DNA Sensing Drives the Innate Immune Response in Malaria Anne OGarra*, MRC National Institute for Medical Research, UK Cytokines and Pathogenesis in TB Short Talk Chosen from Abstracts TUESDAY, MAY 14 Cell Death in Host Resistance and Pathogenesis of Infectious Diseases Douglas R. Green, St. Jude Childrens Research Hospital, USA Pathogen-Induced Necrosis Ricardo T. Gazzineli CPQRRFiociuz Biazil Pyroptosis in Malaria Speaker to be Announced Maya Saleh, McGill University, Canada Role of Caspases in the Regulation of Inlammation and Immunity Short Talk(s) Chosen from Abstracts Immunological Adjuvants and Vaccines Jorge Kalil*, Universidade de So Paolo, Brazil Dengue Vaccine Candidates Robert L. Coffman, Dynavax Technologies, USA Clinical Applications of Innate Immune Signals Bali Pulendran, Emory University, USA Long-Term Immune Responses Induced by Adjuvants Closing Keynote Address Michel C. Nussenzweig, Rockefeller University, USA Targeting Dendritic Cells in Malaria Vaccine WEDNESDAY, MAY 15: DEPARTURE
*Session Chair This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during one of these poster sessions, or a plenary session or workshop. 61 Scientic Organizers: Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes, Anne OGarra and Alan Sher Organized as an international collaboration and with generous support from CNPq the National Council for Scientic and Technological Development, Brazil, and FAPEMIG Minas Gerais State Agency for Research Development. Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill & Melinda Gates Foundation. THE HIPPO TUMOR SUPPRESSOR NETWORK: FROM ORGAN SIZE CONTROL TO STEM CELLS AND CANCER MAY 1923, 2013 HYATT REGENCY MONTEREY, MONTEREY, CALIFORNIA, USA (venue information on page 53) DEADLINES: ABSTRACT & SCHOLARSHIP JAN 17, 2013 LATE-BREAKING ABSTRACT FEB 18, 2013 DISCOUNTED REGISTRATION MAR 19, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13E2 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13E2. Scientic Organizers: Marius Sudol, Helen McNeill, Georg A. Halder and Giovanni Blandino SUNDAY, MAY 19: ARRIVAL & REGISTRATION MONDAY, MAY 20 Keynote Address Joseph Avruch, Massachusetts General Hospital, USA How Does the Core Kinase Cassette of the Hippo Pathway Control the Yki, YAP and TAZ Effectors? Membrane and Upstream Signals Helen McNeill, Samuel Lunenfeld Research Institute, Canada Signals from FAT Receptors in Flies and in Mammals Fernando D. Camargo, Childrens Hospital Boston, USA Hippo Pathway Models in Mice: Stem Cells, Diseases and Emerging Strategies for Therapies Xaralabos Varelas, Boston University, USA Cross-Talk between Hippo, TGF- and Wnt Signaling Pathways Short Talk(s) Chosen from Abstracts Hippo in Flies and Mammals: Orthology and Diversity Duojia (DJ) Pan, Johns Hopkins University School of Medicine, USA Crumbs and Merlin Signaling in Flies and Mammals Nicolas Tapon, Cancer Research UK London Research Institute, UK New Approaches to Deine the Extended Network of the Hippo Pathway in Drosophila Fly Implications for the Mammalian Pathway Joan S. Brugge, Harvard Medical School, USA The Role of YAP Oncogene in Cytokinesis Short Talk Chosen from Abstracts TUESDAY, MAY 21 Junctional Complexes and the Hippo Pathway Joseph L. Kissil, Wistar Institute, USA Angiomotins, Merlin and Tumor Suppression Mechanisms in Mice and Men Wan Jin Hong, Institute of Molecular and Cell Biology, Singapore Angiomotins Use YAP/TAZ as a Shuttle between Junctional Complexes and Nuclear Signaling Georg A. Halder, University of Texas MD Anderson Cancer Center, USA Regulation of the Hippo Pathway by Cell Polarity and Mechanical Forces Hiroshi Sasaki, Kumamoto University, Institute of Molecular Embryology and Genetics, Japan The Role of YAP and Hippo Pathway in Early Mouse Development Short Talk(s) Chosen from Abstracts Hippo Network in Organ Size Control Junichi Sadoshima, University of Medicine and Dentistry of New Jersey, USA Hippo-Lats and YAP in Heart Development Laura Johnston, Columbia University, USA Organ Size Homeostasis Regulated by Myc and Yki Muhammad Al-Hajj, GlaxoSmithKline, USA Hippo Pathway in Cancer Drug Discovery Short Talk Chosen from Abstracts WEDNESDAY, MAY 22 Deregulation of Hippo Pathway in Cancer Kieran Harvey, Peter MacCallum Cancer Centre, Australia The Hippo Pathway, Tissue Growth and Cancer Yael Aylon, Weizmann Institute of Science, Israel Cooperation between ASPP1 and LATS2 in Tumor Suppression Giovanni Blandino, Regina Elena Cancer Institute, Italy Mechanisms by which cis-platin Treatment of Tumors Affects Hippo Pathway Signaling Stefano Piccolo, University of Padua, Italy Regulation of YAP and TAZ by Tissue Architecture Short Talk(s) Chosen from Abstracts From Structure-Function Analysis to Details of the Mechanisms that Govern Hippo Signaling Tony Pawson, Samuel Lunenfeld Research Institute, Canada Regulation of Rho GTPases and Kinases in Hippo Signaling Kun-Liang Guan, University of California, San Diego, USA YAP/TAZ-TEAD Complex and Transcriptional Program of Proliferation Marius Sudol, Weis Center for Research, USA Hippo Pathway as the WW Domain-Mediated Network of Signals THURSDAY, MAY 23: DEPARTURE
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 62 HUMAN GENOMICS AND PERSONALIZED MEDICINE JUNE 1721, 2013 CLARION HOTEL SIGN, STOCKHOLM, SWEDEN (venue information on page 53) DEADLINES: ABSTRACT & SCHOLARSHIP FEB 20, 2013 LATE-BREAKING ABSTRACT MAR 19, 2013 DISCOUNTED REGISTRATION APR 16, 2013 Submit your abstract for the opportunity to be selected as a presenter during a poster or plenary session. WWW.KEYSTONESYMPOSIA.ORG/13E3 Program current as of June 18, 2012 but subject to change; visit WWW.KEYSTONESYMPOSIA.ORG/13E3. Scientic Organizers: Kelly A. Frazer and Geoffrey S. Ginsburg Organized in collaboration with Knut and Alice Wallenberg Foundation and Science for Life Laboratory Stockholm Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc. and Onyx Pharmaceuticals, Inc. MONDAY, JUNE 17: ARRIVAL & REGISTRATION Keynote Address John Bell, University of Oxford, UK Breakthroughs in Genomic and Personalized Medicine Peter Mueller, Vertex Pharmaceuticals Incorporated, USA Target Therapy for Cystic Fibrosis: From Gene to Patient Geoffrey S. Ginsburg, Duke University, USA Novel Host-Based Approaches to the Diagnosis of Infectious Disease Speaker to be Announced Late-Breaking Findings TUESDAY, JUNE 18 Genomes and Biology Richard P. Lifton
, HHMI/Yale University School of Medicine, USA
Talk Title to be Determined Kelly A. Frazer, University of California, San Diego, USA The Role of Regulatory Variants in Disease Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA The Epigenetic Basis of Common Human Disease Speaker to be Announced Cancer Genomics and Applications Paul S. Mischel, University of California, Los Angeles, USA The Cancer Genome Atlas and the Future of Cancer Diagnosis and Treatment Steven Shak, Genomic Health Inc., USA Translating Genomics into Clinical Practice: Lessons from Oncotype DX Thomas J. Hudson, Ontario Institute for Cancer Research, Canada Linking Cancer Treatment Decisions with Large-Scale Mutation Surveys Hiroyuki Mano, University of Tokyo/Jichi Medical University, Japan Targeted Therapies in Cancer WEDNESDAY, JUNE 19 Advances and Challenges in the Field Janet Woodcock, US Food and Drug Administration, USA A Regulatory Pathway to Personalized Medicine Jill Mesirov, Broad Institute, USA The Complexity of Complex Data Dan M. Roden, Vanderbilt University School of Medicine, USA Integration and Implementation of Genetic Information into Health Systems Howard J. Jacob, Medical College of Wisconsin, USA Advances in Clinical Sequencing Pharmacogenomics Alan R. Shuldiner, University of Maryland School of Medicine, USA Genomic Management of Anti-Platelet Therapeutics Howard McLeod, University of North Carolina at Chapel Hill, USA Pharmacogenetics of Cancer Therapeutics Keith J. Johnson, Novartis Institutes for BioMedical Research, Inc., USA Innovations in Pharmacogenomics-Enabled Drug Development Y.T. Chen, Duke University, USA Realizing the Promise of Personalized Medicine: HLA-B*1502 Screen in Preventing Carbamazepine-Induced Toxic Effects WEDNESDAY, JUNE 19 CONTINUED Personalized Genomes Michael Snyder, Stanford University School of Medicine, USA Adventures in Personal Genomics: iPOP of Healthy and Disease States William A. Gahl, NHGRI, National Institutes of Health, USA Whole Exome Sequencing for Undiagnosed Diseases George M. Church, Harvard Medical School, USA The Personal Genome Project and the Future of Medicine THURSDAY, JUNE 20 Policy Susanne B. Haga, Duke University, USA Introducing Genomics in the Clinic: Development of New Delivery Systems Laura Lyman Rodriguez, NHGRI, National Institutes of Health, USA Bringing Genomics into Medicine: Advancing the Policy Agenda Katherine Payne, University of Manchester, UK Quantifying the Economic Value of Personalized Medicine Jane Kaye, University of Oxford, UK Privacy, Data-Sharing Frameworks, Global Governance and Translational Research Translating Biomarkers to Personalized Medicine Michelle Penny, Eli Lilly and Company, USA Integration of Genomic Technologies into Drug Discovery and Development Jonathan K.C. Knowles, cole Polytechnique Fdrale de Lausanne (EPFL), Switzerland Developing Diagnostics from Biomarkers Thomas Metcalfe, Oncotest GmbH Institute for Experimental Oncology, Germany Co-Development of Therapeutics and Companion Diagnostics FRIDAY, JUNE 21: DEPARTURE
Invited, not yet accepted
This conference will also feature poster sessions, providing excellent opportunities to network and discuss your research. Submit your abstract online by the deadlines listed above for the chance to present during a poster or plenary session. 63 CHAMPIONS Highest-tier donors, contributing $100,000+ annually Bill & Melinda Gates Foundation Merck & Co., Inc. Minas Gerais State Agency for Research Development (FAPEMIG) Brazil National Institute of Diabetes and Digestive and Kidney Diseases, NIH National Council foi Scientiic anu Technological Development (CNPq) Brazil SUSTAINING BENEFACTORS Donors making a three-year or ongoing commitment of $50,000$99,999 per year Bayer USA Foundation Takeda Pharmaceutical Company Limited BENEFACTORS Donating $50,000$99,999 Educational donation provided by Amgen Genentech, Inc. National Multiple Sclerosis Society SUSTAINING SPONSORS Donors making a three-year commitment of $25,000$49,999 per year Abbott Laboratories Astellas Pharma Inc. Biogen Idec Boehringer Ingelheim Pharmaceuticals, Inc. Celgene Corporation Gilead Sciences, Inc. Hoffmann-La Roche Inc. SPONSORS Contributing $25,000$49,999 AstraZeneca Pharmaceuticals, L.P. Bristol-Myers Squibb GlaxoSmithKline Isis Pharmaceuticals, Inc. Janssen Pharmaceuticals, Inc. Educational grant from Lilly USA, LLC PARTNERS ($10,000$24,999) Cell Signaling Technology, Inc. The Ellison Medical Foundation PATRONS ($5,000$9,999) AdipoGen International Avanti Polar Lipids CEDARLANE Laboratories DONORS ($2,500$4,999) Agilent Technologies American Heart Association's Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation BioVentures, Inc. Bruker Biospin Corp. ChemoCentryx, Inc. Chroma Technology Corporation Cubist Pharmaceuticals, Inc. Essential Pharmaceuticals, LLC CONTRIBUTORS (up to $2,499) American Heart Association's Council on Cardiovascular Disease in the Young Echelon Biosciences Incorporated 64 THANK YOU FOR YOUR SUPPORT OF THE 20122013 CONFERENCE SERIES National Institute of General Medical Sciences, NIH Minority Access to Research Careers (MARC) Novartis Institutes for BioMedical Research 0fice of AIBS Reseaich NIB Science for Life Laboratory Stockholm Knut and Alice Wallenberg Foundation Nestl Institute of Health Sciences Novo Nordisk A/S Pizei Inc Ininity Phaimaceuticals MedImmune Onyx Pharmaceuticals, Inc. Regulus Therapeutics Inc. Sangamo BioSciences, Inc. Vertex Pharmaceuticals Incorporated Medicines for Malaria Venture Ian Bathurst Global Health Travel Awards Monsanto Company Novartis Pharma K.K. Sanoi 0S ISOTEC, a member of the Sigma-Aldrich Group Opsona Therapeutics Ltd Promega Corporation The Rockefeller University Press The Journal of Experimental Medicine Sigma Life Science STEMCELL Technologies Syngenta Biotechnology, Inc. Novus Biologicals Seahorse Bioscience, Inc. New Era Enterprises, Inc. Rigaku Americas Corporation Landes Bioscience THANK YOU FOR YOUR SUPPORT OF THE 20122013 CONFERENCE SERIES DIRECTORS FUND SPONSORS Donors with unrestricted gifts of at least $25,000. These generous gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research. Abbott Laboratories Educational donation provided by Amgen Astellas Pharma Inc. Bayer USA Foundation Biogen Idec Boehringer Ingelheim Pharmaceuticals, Inc. Bristol-Myers Squibb Celgene Corporation Genentech, Inc. Gilead Sciences, Inc. GlaxoSmithKline Hoffmann-La Roche Inc. Ininity Phaimaceuticals Isis Pharmaceuticals, Inc. Janssen Pharmaceuticals, Inc. DIRECTORS FUND Gifts made to the Directors Fund are used at the discretion of Keystone Symposias President/CEO and Directors. We gratefully acknowledge the following donors, whose gifts allow Keystone Symposia to subsidize a wide variety of meetings and provide scholarships to talented graduate students and postdoctoral fellows. AdipoGen International Agilent Technologies Avanti Polar Lipids BioVentures, Inc. Bruker Biospin Corp. CEDARLANE Laboratories ChemoCentryx, Inc. Chroma Technology Corporation Cubist Pharmaceuticals, Inc. Echelon Biosciences Incorporated Essential Pharmaceuticals, LLC ISOTEC, a member of the Sigma-Aldrich Group KEYSTONE SYMPOSIA FUTURE OF SCIENCE FUND Gifts from individuals provide funding for general and underrepresented minority scholarships and travel awards for investigators from countries most affected by topics of specic meetings. Funds can also be designated to support general meeting program expenses, as well as program costs for specic meetings of choice. The donors below gave during the 12 months ending June 18, 2012. PRESIDENTS CIRCLE ($10,000+) The Elkes Foundation FOUNDERS SOCIETY ($5,000$9,999) A.J. Miller KEYSTONE CHAMPIONS ($1,000$4,999) Jim & Sue Aiken Christopher Atwood Kenneth W. Bair Edward A. Dennis Margaret Liu, Robert Johnson Masaru Okabe Anthony Pawson Alessanuio Pocai Naico anu Soia Pocai with matching gift from Merck Partnership for Giving Roy G. Michell Charitable Foundation and Trust Sidney E. Frank Foundation Craig B. Thompson David and Marcy Woodland Juleen Zierath Anonymous (3) Please visit www.keystonesymposia.org for a list of our Future of Science Fund donors at the Patron and Contributor levels and to learn more about becoming a donor in support of our mission. KEYSTONE BENEFACTORS ($500$999) Raymond N. DuBois Joseph Heitman Laura L. Kiessling, Ronald T. Raines Michinori Kohara Suraj P. Manrao Terry J. Opgenorth Andrew D. Robertson Kazuo Tsubota Sally Wenzel Ian Wilson Masayuki Yamamoto Anonymous (3) 65 Educational grant from Lilly USA, LLC MedImmune Merck & Co., Inc. Monsanto Company Novartis Institutes for BioMedical Research Novo Nordisk A/S Onyx Pharmaceuticals, Inc. Pizei Inc Regulus Therapeutics Inc. Sangamo BioSciences, Inc. Sanoi 0S Takeda Pharmaceutical Company Limited Vertex Pharmaceuticals Incorporated Landes Bioscience Novus Biologicals Opsona Therapeutics Ltd Promega Corporation Rigaku Americas Corporation The Rockefeller University Press The Journal of Experimental Medicine Seahorse Bioscience, Inc. Sigma Life Science STEMCELL Technologies Syngenta Biotechnology, Inc. KEYSTONE SYMPOSIA BOARD AND STAFF (as of June 18, 2012) BOARD OF DIRECTORS Juleen R. Zierath, Ph.D. Chair of the Board, Keystone Symposia Professor, Molecular Medicine and Surgery Karolinska Institutet Craig B. Thompson, M.D. Secretary of the Board Chair, Scientiic Advisory Board Keystone Symposia Piesiuent anu Chief Executive 0ficei Memorial Sloan-Kettering Cancer Center Terry J. Opgenorth, Ph.D. Treasurer of the Board Chair, Finance Committee, Keystone Symposia Vice President CSU Ventures James W. Aiken, Ph.D. Piesiuent anu Chief Executive 0ficei Keystone Symposia on Molecular and Cellular Biology Kenneth W. Bair, Ph.D. Chair, Audit Committee, Keystone Symposia Senior Vice President and Head Reseaich anuBevelopment Forma Therapeutics, Inc. Beverly M. Emerson, Ph.D. Chair, Personnel Committee Keystone Symposia Professor, Regulatory Biology Laboratory The Salk Institute Peter M. Finan, Ph.D. Associate Disease Area Head Respiratory Diseases Novartis Institutes for BioMedical Research Heidi E. Hamm, Ph.D. Professor and Chair Department of Pharmacology Vanderbilt University School of Medicine Edison T. Liu, M.D. Piesiuent anu Chief Executive 0ficei The Jackson Laboratory Margaret A. Liu, M.D. Chair, Development Committee Keystone Symposia ProTherImmune Visiting Professor, Karolinska Institutet Gary J. Nabel, M.D., Ph.D. Bethesda, Maryland Tony Pawson, Ph.D. Senior Investigator Centre for Systems Biology Samuel Lunenfeld Research Institute Mount Sinai Hospital, Toronto Alan Sher, Ph.D. Chair, Nominating Committee Keystone Symposia Bethesda, Maryland Ian A. Wilson, Ph.D., Sc.D., FRS Professor Department of Molecular Biology and The Skaggs Institute for Chemical Biology The Scripps Research Institute EMERITUS BOARD MEMBERS: Ralph A. Bradshaw, Ph.D. Professor Emeritus, Physiology and Biophysics College of Medicine University of California, Irvine Professor in Pharmaceutical Chemistry and Deputy Director of Mass Spectrometry Facility University of California, San Francisco Robert W. Craig President Emeritus, The Keystone Center Edward A. Dennis, Ph.D. Professor, Chemistry, Biochemistry and Pharmacology School of Medicine 0niveisity of CalifoiniaSan Biego Curtis C. Harris, M.D. Chief, Laboratory of Human Carcinogenesis NCI, National Institutes of Health All Board and Emeritus Board Members are also members of Keystone Symposias Scientiic Advisory Board. KEYSTONE SYMPOSIA STAFF James Aiken, Chief Executive Oficer Pamela Daugherty, Chief Financial Oficer David Woodland, Chief Scientiic Oficer Jeannie Dalrymple, Senior Director, Program Development & Implementation Linda Hrycaj, Senior Director, Strategic Planning Christopher Atwood, Director, Development Heidi Daetwyler-Simpson, Director, Meeting Management Laina King, Director, Diversity in Life Science Programs Tanya Muller, Director, Information Technology Yvonne Psaila, Director, Marketing &Communications Mary Jo Roal, Director, Human Resources David Adamson, On-Site Staff Representative Arne Ahlstrom, On-Site Staff Representative Cathy Banks, Web Developer/Systems Analyst Carol Bosserman, On-Site Staff Representative Mary Brown, On-Site Staff Representative Caroline Brendel, Executive Administrative Assistant Melissa Carrera, Assistant Director of Development Linda Cooper, Publications Assistant Amanda Deem, Assistant Director of Development Heather Gerhart, Senior Grant Coordinator & Program Analyst Susan Gunn, Seasonal Logistics Representative Lindsey Heilmann, Conference Coordinator Jenny Hindorff, Program Implementation Associate Kellan Hoover, Marketing Associate Mike Lachata, Information TechnologyProgrammer Sarah Lavicka, Administrative & Research Assistant, Development Jeff Lehman, Scholarship Coordinator Phyllis McNeil, Attendee Services Specialist Allison Ogdon, Program Development Coordinator Annie Page, On-Site Staff Representative McKennzie Rains, IT Support/Assistant Grace Roath, Ofice Manager Julie Roll, On-Site Staff Representative David Sanchez, Manager, Attendee Services Barbara Schmid-Miller, Program Implementation Assistant Gwyn Schmude, Attendee Services Specialist Dawn Shafer, Accounting Clerk Bridget Stacy, Administrative Assistant, Diversity Kathy Tavares, Program Implementation Supervisor Rebecca Wilkerson, Finance Assistant 66 E. Dale Abel, M.D., Ph.D. Professor of Medicine, Biochemistry and Human Genetics Chief, Division of Endocrinology Metabolism and Diabetes Investigator, Program in Molecular Medicine Josie I. Johnson Professorship in Molecular Biology Medicine and Biochemistry The University of Utah School of Medicine Jacques F. Banchereau, Ph.D. Senioi vice Piesiuent anu Chief Scientiic 0ficei Inlammation anu viiology Hoffmann-La Roche Inc. Stephen L. Brenner, Ph.D. Vice President of Molecular Biosciences Bristol-Myers Squibb Company Leslie J. Browne, Ph.D. Piesiuent anu CE0 Senesco Technologies, Inc. Thomas F. Bumol, Ph.D. Vice President, BioTechnology Research Lilly Research Laboratories President and Site Head Applied Molecular Evolution, Inc. and Lilly Biotechnology Center San Diego Judith Campisi, Ph.D. Professor Buck Institute for Research on Aging Arturo Casadevall, M.D. Professor and Chair Microbiology and Immunology Albert Einstein College of Medicine Hubert C. Chen, M.D. Vice President, Translational Medicine Regulus Therapeutics Inc. Robert L. Coffman, Ph.D. vice Piesiuent anu Chief Scientiic 0ficei Dynavax Technologies Max D. Cooper, M.D. Georgia Research Alliance Eminent Scholar Professor of Pathology and Laboratory Medicine Emory University School of Medicine Alan J. Cross, Ph.D. Chief Scientist, CNS and Pain Innovative Medicines AstraZeneca Pharmaceuticals Manoj C. Desai, Ph.D. Vice President, Medicinal Chemistry Gilead Sciences, Inc. Vishva M. Dixit, M.D. Vice President, Research Physiological Chemistry Genentech, Inc. Robert H. Eckel, M.D. Charles A. Boettcher Endowed Chair in Atherosclerosis Professor of Medicine and of Physiology and Biophysics Program Director, Adult GCRC Medicine/Endocrinology University of Colorado Denver Anschutz Medical Campus Martin P. Edwards, Ph.D. Vice President, Cancer Chemistry Pizei La }olla Lee M. Ellis, M.D. Professor Cancei Biology anu Suigical 0ncology The University of Texas MD Anderson Cancer Center I. Sadaf Farooqi, Ph.D., FRCP Wellcome Trust Senior Clinical Fellow and Reader in Human Metabolism Metabolic Research Laboratories University of Cambridge Curt R. Freed, M.D. Professor and Head Division of Clinical Pharmacology and Toxicology University of Colorado Denver School of Medicine Adolfo Garcia-Sastre, Ph.D. Professor, Department of Microbiology Co-Director, Emerging Pathogens Institute Mount Sinai School of Medicine Tariq Ghayur, Ph.D. Research Fellow Abbott Bioresearch Center Margaret Peggy A. Goodell, Ph.D. Piofessoi Peuiatiics Bematology0ncology Director, Star Center Center for Cell and Gene Therapy Baylor College of Medicine Douglas R. Green, Ph.D. Doherty Chair of Immunology Department of Immunology St. Jude Childrens Research Hospital Philip D. Gregory, Ph.D. Chief Scientiic 0ficei Reseaich Sangamo Biosciences, Inc. Diane E. Grifin, M.D., Ph.D. Professor and Chair Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Jacqueline E. Heard, Ph.D. Venture Capital Principal Global Strategy and R&D Investment Monsanto Company Kim A. Heidenreich, Ph.D. Professor, Department of Pharmacology University of Colorado Denver (UCHSC) Christopher L. Karp, MD Deputy Director Vaccines & Host-Pathogen Biology Global Health Discovery & Translational Sciences Bill & Melinda Gates Foundation Elliott D. Kieff, M.D., Ph.D. Albee Professor Medicine, Microbiology and Molecular Genetics Harvard University Laura L. Kiessling, Ph.D. Hilldale Professor of Chemistry Laurens Anderson Professor of Biochemistry Department of Chemistry and Biochemistry University of Wisconsin-Madison Jacqueline Kirchner, Ph.D. Scientiic Biiectoi Inlammation Amgen Inc. Christopher Kirk, Ph.D. Vice President, Research 0nyx Phaimaceuticals Inc Jan E. Leach, Ph.D. University Distinguished Professor Bioagricultural Sciences Colorado State University Karolin Luger, Ph.D. HHMI Investigator and Professor Department of Molecular Biology and Biochemistry Colorado State University Lamine MBow, Ph.D. Director Immunology anu Inlammation Boehringer Ingelheim Elizabeth M. McNally, M.D., Ph.D. Professor Department of Medicine and Human Genetics University of Chicago Juanita L. Merchant, M.D., Ph.D. Departments of Internal Medicine and Molecular and Integrative Physiology University of Michigan Tara Mirzadegan, Ph.D. Team Leader, Computational Chemistry Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Hiroyuki Odaka, Ph.D. General Manager, Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Anne OGarra, Ph.D., FRS, FMedSci Head, Division of Immunoregulation MRC National Institute for Medical Research Vito J. Palombella, Ph.D. Chief Scientiic 0ficei Ininity Phaimaceuticals Inc Eric M. Parker, Ph.D. Senior Director and Neuroscience Site Lead Neuioscience anu 0phthalmology Merck Research Laboratories Catherine E. Peishoff, Ph.D. Vice President Computational and Structural Chemistry GlaxoSmithKline Pharmaceuticals Ronald T. Raines, Ph.D. Professor, Departments of Biochemistry and Chemistry University of WisconsinMadison Greg Reyes, M.D., Ph.D. Senior Vice President Drug Discovery Celgene Corporation Roger R. Reddel, Ph.D. Director Childrens Medical Research Institute, Sydney Juan Rivera, Ph.D. Deputy Director, Intramural Research Program Chief, Laboratory of Molecular Immunogenetics and Molecular Immunology Section NIAMS, National Institutes of Health Cristina M. Rondinone, Ph.D. Vice President, Research & Development Head, Cardiovascular & Metabolic Diseases MedImmune Nadia A. Rosenthal, Ph.D. Director of EMBL Monterotondo Mouse Biology Unit European Molecular Biology Laboratory Andrej Sali, Ph.D. Professor, Bioengineering and Therapeutic Sciences University of California, San Francisco Martin Schneider, Ph.D. Senior Vice President, Global Therapeutical Research Professor, Global Drug Discovery Bayer HealthCare AG Stephen J. Simpson, Ph.D. Life Sciences Directorate Science Foundation Ireland Frank J. Slack, Ph.D. Professor, Molecular, Cellular and Developmental Biology Yale University Didier Y.R. Stainier, Ph.D. Professor, Department of Biochemistry and Biophysics School of Medicine University of California, San Francisco Eric E. Swayze, Ph.D. Vice President, Medicinal Chemistry Isis Pharmaceuticals, Inc. Doris A. Taylor, Ph.D. Director Regenerative Medicine Research Texas Heart Institute Thomas Tuschl, Ph.D. HHMI Investigator and Associate Professor Laboratory of RNA Molecular Biology The Rockefeller Institute Joanne Jo L. Viney, Ph.D. Vice President, Immunology Research Biogen Idec Nicolai R. Wagtmann, Ph.D. vice Piesiuent anu Beau of Inlammation Biology Biopharmaceuticals Research Unit Novo Nordisk A/S Michael J.O. Wakelam, Ph.D. Institute Director The Babraham Institute Andrew Ward, Ph.D. Assistant Professor Molecular Biology The Scripps Research Institute David R. Webb, Ph.D. Adjunct Professor Department of Molecular Biology The Scripps Research Institute Kenneth F. Wertman, Ph.D. Scientiic Biiectoi Tucson Associate Vice President Discovery Research Chemical and Analytical Sciences Sanoi 0S David L. Woodland, Ph.D. Chief Scientiic 0ficei Keystone Symposia on Molecular and Cellular Biology KEYSTONE SYMPOSIA SCIENTIFIC ADVISORY BOARD (as of June 18, 2012) 67 KEYSTONE SYMPOSIA 20122013 Conference Series www.keystonesymposia.org Visit www.keystonesymposia.org/meetings or call 1.800.253.0685 or 1.970.262.1230 for the most current information and to register. The 20122013 KeYSTONe SYMPOSIA CONfereNCe SerIeS AT A GlANCe September 2012 Pulmonary Vascular Disease and Right Ventricular Dysfunction: Current Concepts and Future Therapies (S1), Monterey, CA, USA #KSPVD October 2012 Aging and Diseases of Aging (S2), Tokyo, Japan #KSaging December 2012 Immunological Mechanisms of Vaccination (S3), Ottawa, ON, Canada #KSvaccine January 2013 Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1) joint with Pathogenic Processes in Asthma and COPD (J2), Santa fe, NM, USA #KSimmunity / #KSlung Multiple Sclerosis (A1), Big Sky, MT, USA #KSMS New Frontiers in Cardiovascular Genetics Beyond GWAS (A2), Tahoe City, CA, USA #KScardio Frontiers of NMR in Biology (A3), Snowbird, Utah, USA #KSNMr Hematopoiesis (A4), Steamboat Springs, CO, USA #KShema Emerging Topics in Immune System Plasticity: Cellular Networks, Metabolic Control and Regeneration (A5), Santa fe, NM, USA #KSimmunity Plant Abiotic Stress and Sustainable Agriculture: Translating Basic Understanding to Food Production (A6), Taos, NM, USA #KSplant Noncoding RNAs in Development and Cancer (A7), Vancouver, BC, Canada #KSncrNA Malaria (A8), New Orleans, lA, USA #KSmalaria Metabolic Control of Infammation and Immunity (A9), Breckenridge, CO, USA #KSimmunity Antibodies as Drugs (J3) joint with Cancer Immunology and Immunotherapy (J4), Vancouver, BC, Canada #KSdrug / #KScancer Adipose Tissue Biology (J5) joint with Diabetes New Insights into Mechanism of Disease and its Treatment (J6), Keystone, CO, USA #KSadipose / #KSdiabetes February 2013 Mitochondria, Metabolism and Myocardial Function Basic Advances to Translational Studies (B1), Keystone, CO, USA #KSmitochondria Neurogenesis (J7) joint with New Frontiers in Neurodegenerative Disease Research (J8), Santa fe, NM, USA #KSneuro Lung Development, Cancer and Disease (B2), Taos, NM, USA #KSlung The Gut Microbiome: The Effector/Regulatory Immune Network (B3), Taos, NM, USA #KSgut B Cell Development and Function (X1) joint with HIV Vaccines (X2), Keystone, CO, USA #KSbcell / #KShIV Autophagy, Infammation and Immunity (B4), Montreal, QC, Canada #KSautophagy Nutrition, Epigenetics and Human Disease (B5), Santa fe, NM, USA #KSnutrition Myeloid Cells: Regulation and Infammation (B6), Keystone, CO, USA #KSmyeloid February 2013 (continued) Stem Cell Regulation in Homeostasis and Disease (B7), Banff, AB, Canada #KSstemcell PI 3-Kinase and Interplay with Other Signaling Pathways (X3) joint with Tumor Metabolism (X4), Keystone, CO, USA #KSPI3K / #KScancer March 2013 Structural Analysis of Supramolecular Assemblies by Hybrid Methods (C1), Tahoe City, CA, USA #KSsupramolecular Understanding Dendritic Cell Biology to Advance Disease Therapies (C2), Keystone, CO, USA #KSdendritic DNA Replication and Recombination (X5) joint with Genomic Instability and DNA Repair (X6), Banff, AB, Canada #KSDNA Growing to Extremes: Cell Biology and Pathology of Axons (C4), Tahoe City, CA, USA #KSaxon Host Response in Tuberculosis (X7) joint with Tuberculosis: Understanding the Enemy (X8), Whistler, BC, Canada #KSTB Precision Genome Engineering and Synthetic Biology: Designing Genomes and Pathways (C5), Breckenridge, CO, USA #KSgenome Neuronal Control of Appetite, Metabolism and Weight (C6), Banff, AB, Canada #KSobesity RNA Silencing (C7), Whistler, BC, Canada #KSrNA Epigenetic Marks and Cancer Drugs (C8), Santa fe, NM, USA #KScancer April 2013 Molecular Clockworks and the Regulation of Cardio-Metabolic Function (C9), Snowbird, Utah, USA #KScardio Immune Activation in HIV Infection: Basic Mechanisms and Clinical Implications (D2), Breckenridge, CO, USA #KShIV Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction (D3), Alpbach, Austria #KSnuclear Immunopathology of Type 1 Diabetes (Z1) joint with Advances in the Knowledge and Treatment of Autoimmunity (Z2), Whistler, BC, Canada #KSdiabetes / #KSautoimmunity Cardiac Remodeling, Signaling, Matrix and Heart Function (D4), Snowbird, UT, USA #KScardio Plant Immunity: Pathways and Translation (D5), Big Sky, MT, USA #KSplant Positive Strand RNA Viruses (D7), Boston, MA, USA #KSrNA May 2013 The Innate Immune Response in the Pathogenesis of Infectious Disease (E1), Ouro Preto, MG, Brazil #KSimmunity The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer (E2), Monterey, CA, USA #KShippo June 2013 Human Genomics and Personalized Medicine (E3), Stockholm, Sweden #KSgenome PO Box 1630 | 160 US highway 6, Suite 200 Silverthorne, Colorado 80498 | USA 1.970.262.1230 | 1.800.253.0685 (US & Canada) www.keystonesymposia.org/meetings Scan the QR code to the right with your mobile device to view this list online. printed on 10% post-consumer-waste recycled paper Follow us: a 501(c)(3) nonproft educational organization